Datasets:
bio-datasets
/
bigbio-ner-merged

Dataset card Data Studio Files
xet
Community
answer
stringlengths
1
16.1k
id
stringlengths
7
56
instruction
stringlengths
106
72.6k
ner_tags
list
text
stringlengths
5
72.4k
tokens
list
types
list
primary sleep disorder, other, RLS, Serum ferritin, < 20 ng / mL, allergy , hypersensitivity , or intolerance, HORIZANT or any other gabapentin products ( eg , Neurontin ® , Gralise ®, movement disorder, Tourette 's syndrome , tic disorder , periodic limb movement disorder [ PLMD ] , sleep disorders, Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition, DSM-5, substance use disorder, within 12 months, significant, psychiatric disorder, depression ( treatment with antidepressants ) , bipolar disorder , or schizophrenia, attention - deficit hyperactivity disorder, ADHD, allowed, suicidal behavior, suicidal ideation, seizure disorder, complicated febrile seizure and history of significant head injury
NCT02560766_exc_task2
Sentence: History of a primary sleep disorder other than RLS that may significantly affect the symptoms of RLS. Serum ferritin level < 20 ng/mL at screening. History of allergy, hypersensitivity, or intolerance to HORIZANT or any other gabapentin products (eg, Neurontin®, Gralise®). Suffering from a movement disorder that could mimic or confound the accurate diagnosis of RLS (eg, Tourette's syndrome, tic disorder, periodic limb movement disorder [PLMD], sleep disorders). Currently meet Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) criteria for substance use disorder, or history thereof, within 12 months before dosing. Current or past history of any significant psychiatric disorder including, but not limited to, depression (treatment with antidepressants), bipolar disorder, or schizophrenia. Diagnosis of attention-deficit hyperactivity disorder (ADHD) is allowed, provided the patient is not receiving medication(s) known to affect the assessment of RLS. History of suicidal behavior or suicidal ideation as indicated by the C-SSRS, administered at screening (the questionnaire is provided in Appendix 4), and as per investigator's judgment. History of seizure disorder or at increased risk for development of a seizure disorder including, but not limited to, complicated febrile seizure and history of significant head injury. Medical condition or disorder that would interfere with the action, absorption, distribution, metabolism, or excretion of gabapentin enacarbil, or, in the investigator's judgment is considered to be clinically significant and may pose a safety concern, or, could interfere with the accurate assessment of safety or efficacy, or could potentially affect a patient's safety or study outcome. Clinically significant abnormal laboratory result or physical examination finding not resolved by the time of baseline assessments. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "O", "B-Negation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
History of a primary sleep disorder other than RLS that may significantly affect the symptoms of RLS. Serum ferritin level < 20 ng/mL at screening. History of allergy, hypersensitivity, or intolerance to HORIZANT or any other gabapentin products (eg, Neurontin®, Gralise®). Suffering from a movement disorder that could mimic or confound the accurate diagnosis of RLS (eg, Tourette's syndrome, tic disorder, periodic limb movement disorder [PLMD], sleep disorders). Currently meet Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) criteria for substance use disorder, or history thereof, within 12 months before dosing. Current or past history of any significant psychiatric disorder including, but not limited to, depression (treatment with antidepressants), bipolar disorder, or schizophrenia. Diagnosis of attention-deficit hyperactivity disorder (ADHD) is allowed, provided the patient is not receiving medication(s) known to affect the assessment of RLS. History of suicidal behavior or suicidal ideation as indicated by the C-SSRS, administered at screening (the questionnaire is provided in Appendix 4), and as per investigator's judgment. History of seizure disorder or at increased risk for development of a seizure disorder including, but not limited to, complicated febrile seizure and history of significant head injury. Medical condition or disorder that would interfere with the action, absorption, distribution, metabolism, or excretion of gabapentin enacarbil, or, in the investigator's judgment is considered to be clinically significant and may pose a safety concern, or, could interfere with the accurate assessment of safety or efficacy, or could potentially affect a patient's safety or study outcome. Clinically significant abnormal laboratory result or physical examination finding not resolved by the time of baseline assessments.
[ "History", "of", "a", "primary", "sleep", "disorder", "other", "than", "RLS", "that", "may", "significantly", "affect", "the", "symptoms", "of", "RLS", ".", "\n", "Serum", "ferritin", "level", "<", "20", "ng", "/", "mL", "at", "screening", ".", "\n", "History", "of", "allergy", ",", "hypersensitivity", ",", "or", "intolerance", "to", "HORIZANT", "or", "any", "other", "gabapentin", "products", "(", "eg", ",", "Neurontin", "®", ",", "Gralise", "®", ")", ".", "\n", "Suffering", "from", "a", "movement", "disorder", "that", "could", "mimic", "or", "confound", "the", "accurate", "diagnosis", "of", "RLS", "(", "eg", ",", "Tourette", "'s", "syndrome", ",", "tic", "disorder", ",", "periodic", "limb", "movement", "disorder", "[", "PLMD", "]", ",", "sleep", "disorders", ")", ".", "\n", "Currently", "meet", "Diagnostic", "and", "Statistical", "Manual", "of", "Mental", "Disorders", "-", "Fifth", "Edition", "(", "DSM-5", ")", "criteria", "for", "substance", "use", "disorder", ",", "or", "history", "thereof", ",", "within", "12", "months", "before", "dosing", ".", "\n", "Current", "or", "past", "history", "of", "any", "significant", "psychiatric", "disorder", "including", ",", "but", "not", "limited", "to", ",", "depression", "(", "treatment", "with", "antidepressants", ")", ",", "bipolar", "disorder", ",", "or", "schizophrenia", ".", "\n", "Diagnosis", "of", "attention", "-", "deficit", "hyperactivity", "disorder", "(", "ADHD", ")", "is", "allowed", ",", "provided", "the", "patient", "is", "not", "receiving", "medication(s", ")", "known", "to", "affect", "the", "assessment", "of", "RLS", ".", "\n", "History", "of", "suicidal", "behavior", "or", "suicidal", "ideation", "as", "indicated", "by", "the", "C", "-", "SSRS", ",", "administered", "at", "screening", "(", "the", "questionnaire", "is", "provided", "in", "Appendix", "4", ")", ",", "and", "as", "per", "investigator", "'s", "judgment", ".", "\n", "History", "of", "seizure", "disorder", "or", "at", "increased", "risk", "for", "development", "of", "a", "seizure", "disorder", "including", ",", "but", "not", "limited", "to", ",", "complicated", "febrile", "seizure", "and", "history", "of", "significant", "head", "injury", ".", "\n", "Medical", "condition", "or", "disorder", "that", "would", "interfere", "with", "the", "action", ",", "absorption", ",", "distribution", ",", "metabolism", ",", "or", "excretion", "of", "gabapentin", "enacarbil", ",", "or", ",", "in", "the", "investigator", "'s", "judgment", "is", "considered", "to", "be", "clinically", "significant", "and", "may", "pose", "a", "safety", "concern", ",", "or", ",", "could", "interfere", "with", "the", "accurate", "assessment", "of", "safety", "or", "efficacy", ",", "or", "could", "potentially", "affect", "a", "patient", "'s", "safety", "or", "study", "outcome", ".", "\n", "Clinically", "significant", "abnormal", "laboratory", "result", "or", "physical", "examination", "finding", "not", "resolved", "by", "the", "time", "of", "baseline", "assessments", ".", "\n" ]
[ "Scope", "Measurement", "Condition", "Observation", "Temporal", "Drug", "Qualifier", "Value", "Negation" ]
10034C > T is a DNAMutation
45_task0
Sentence: The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNAMutation
[ "O", "O", "O", "B-DNAMutation", "I-DNAMutation", "I-DNAMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.
[ "The", "fibrinogen", "gamma", "10034C", ">", "T", "polymorphism", "is", "not", "associated", "with", "Peripheral", "Arterial", "Disease", "." ]
[ "SNP", "DNAMutation" ]
10034C > T is a DNAMutation
45_task1
Sentence: The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. Instructions: please typing these entity words according to sentence: 10034C > T Options: DNAMutation
[ "O", "O", "O", "B-DNAMutation", "I-DNAMutation", "I-DNAMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.
[ "The", "fibrinogen", "gamma", "10034C", ">", "T", "polymorphism", "is", "not", "associated", "with", "Peripheral", "Arterial", "Disease", "." ]
[ "SNP", "DNAMutation" ]
10034C > T
45_task2
Sentence: The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-DNAMutation", "I-DNAMutation", "I-DNAMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.
[ "The", "fibrinogen", "gamma", "10034C", ">", "T", "polymorphism", "is", "not", "associated", "with", "Peripheral", "Arterial", "Disease", "." ]
[ "SNP", "DNAMutation" ]
c - fos is a Protein, c - jun is a Protein, c - fos is a Protein, c - jun is a Protein, promoter elements is a Entity, c - Fos is a Protein, c - Jun is a Protein, AP-1 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 is a Entity, CD3epsilon is a Protein, PHA is a Protein, c - Fos is a Protein, c - Fos is a Protein, c - Jun is a Protein, CD3 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 consensus TRE motif is a Entity, c - jun is a Protein, TRE - like promoter element is a Entity, c - fos is a Protein, serum response element is a Entity, SRE is a Entity, nuclear protein complexes is a Entity, c - jun is a Protein, c - fos is a Protein, DNA sequence motifs is a Entity, AP-1 is a Entity, c - jun is a Protein, c - fos is a Protein, binding complexes is a Entity, nuclear protein complexes is a Entity, SRE motif is a Entity, serum response factor is a Protein, Elk-1 is a Protein, c - jun is a Protein, / AP-1 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 is a Entity
196_task0
Sentence: Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
[ "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O" ]
Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.
[ "Impaired", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "genes", "and", "of", "transcriptional", "regulatory", "proteins", "binding", "distinct", "c", "-", "fos", "/", "c", "-", "jun", "promoter", "elements", "in", "activated", "human", "T", "cells", "during", "aging", ".", "\n", "The", "activation", "of", "transcriptional", "factor", "c", "-", "Fos", "/", "c", "-", "Jun", "AP-1", "is", "essential", "for", "normal", "T", "cell", "responsiveness", "and", "is", "often", "impaired", "in", "T", "cells", "during", "aging", ".", "In", "the", "present", "study", ",", "we", "investigated", "whether", "aberrancies", "in", "the", "regulation", "of", "c", "-", "fos", "/", "c", "-", "jun", "at", "the", "mRNA", "or", "protein", "level", "might", "underlie", "the", "age", "-", "associated", "impairments", "of", "AP-1", "in", "human", "T", "cells", ".", "Whereas", "T", "cells", "from", "young", "subjects", "stimulated", "with", "cross", "-", "linked", "anti", "-", "CD3epsilon", "mAb", "OKT3", "plus", "PMA", "or", "with", "the", "lectin", "PHA", "plus", "PMA", "demonstrated", "considerable", "increases", "in", "c", "-", "Fos", "protein", "expression", ",", "the", "expression", "of", "c", "-", "Fos", "but", "not", "c", "-", "Jun", "was", "markedly", "reduced", "in", "stimulated", "T", "cells", "from", "certain", "elderly", "subjects", ".", "In", "addition", ",", "RNase", "protection", "assays", "revealed", "that", "anti", "-", "CD3", "/", "PMA", "-", "stimulated", "T", "cells", "from", "a", "substantial", "proportion", "of", "elderly", "subjects", "exhibited", "decreased", "levels", "of", "c", "-", "fos", "and", "/", "or", "c", "-", "jun", "mRNA", "compared", "to", "T", "cells", "from", "young", "subjects", ".", "Using", "electrophoretic", "mobility", "shift", "assays", ",", "the", "levels", "of", "nuclear", "regulatory", "proteins", "recognizing", "the", "AP-1", "consensus", "TRE", "motif", ",", "the", "proximal", "c", "-", "jun", "TRE", "-", "like", "promoter", "element", ",", "and", "the", "c", "-", "fos", "serum", "response", "element", "(", "SRE", ")", "were", "determined", "in", "resting", "and", "stimulated", "T", "cells", ".", "Although", "the", "stimulation", "of", "T", "cells", "from", "young", "subjects", "resulted", "in", "coordinated", "increases", "of", "nuclear", "protein", "complexes", "binding", "the", "AP-1", "TRE", ",", "c", "-", "jun", "TRE", ",", "and", "c", "-", "fos", "SRE", "DNA", "sequence", "motifs", ",", "age", "-", "related", "reductions", "in", "the", "activation", "of", "AP-1", "were", "accompanied", "by", "decreased", "levels", "of", "c", "-", "jun", "TRE", "and", "c", "-", "fos", "SRE", "binding", "complexes", ".", "Furthermore", ",", "the", "nuclear", "protein", "complexes", "binding", "the", "SRE", "motif", "induced", "in", "activated", "T", "cells", "of", "young", "and", "elderly", "subjects", "contained", "serum", "response", "factor", "and", "Elk-1", "pointing", "toward", "age", "-", "related", "defects", "in", "the", "activation", "of", "transcriptional", "regulatory", "proteins", "distinct", "from", "c", "-", "jun", "/", "AP-1", ".", "These", "results", "suggest", "that", "underlying", "aberrancies", "in", "the", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "as", "well", "as", "their", "nuclear", "regulatory", "proteins", "may", "contribute", "to", "the", "age", "-", "related", "impairments", "of", "AP-1", "activation", "in", "human", "T", "cells", ".", "\n" ]
[ "Entity", "Protein" ]
c - fos is a Protein, c - jun is a Protein, c - fos is a Protein, c - jun is a Protein, promoter elements is a Entity, c - Fos is a Protein, c - Jun is a Protein, AP-1 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 is a Entity, CD3epsilon is a Protein, PHA is a Protein, c - Fos is a Protein, c - Fos is a Protein, c - Jun is a Protein, CD3 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 consensus TRE motif is a Entity, c - jun is a Protein, TRE - like promoter element is a Entity, c - fos is a Protein, serum response element is a Entity, SRE is a Entity, nuclear protein complexes is a Entity, c - jun is a Protein, c - fos is a Protein, DNA sequence motifs is a Entity, AP-1 is a Entity, c - jun is a Protein, c - fos is a Protein, binding complexes is a Entity, nuclear protein complexes is a Entity, SRE motif is a Entity, serum response factor is a Protein, Elk-1 is a Protein, c - jun is a Protein, / AP-1 is a Entity, c - fos is a Protein, c - jun is a Protein, AP-1 is a Entity
196_task1
Sentence: Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells. Instructions: please typing these entity words according to sentence: c - fos, c - jun, c - fos, c - jun, promoter elements, c - Fos, c - Jun, AP-1, c - fos, c - jun, AP-1, CD3epsilon, PHA, c - Fos, c - Fos, c - Jun, CD3, c - fos, c - jun, AP-1 consensus TRE motif, c - jun, TRE - like promoter element, c - fos, serum response element, SRE, nuclear protein complexes, c - jun, c - fos, DNA sequence motifs, AP-1, c - jun, c - fos, binding complexes, nuclear protein complexes, SRE motif, serum response factor, Elk-1, c - jun, / AP-1, c - fos, c - jun, AP-1 Options: Entity, Protein
[ "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O" ]
Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.
[ "Impaired", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "genes", "and", "of", "transcriptional", "regulatory", "proteins", "binding", "distinct", "c", "-", "fos", "/", "c", "-", "jun", "promoter", "elements", "in", "activated", "human", "T", "cells", "during", "aging", ".", "\n", "The", "activation", "of", "transcriptional", "factor", "c", "-", "Fos", "/", "c", "-", "Jun", "AP-1", "is", "essential", "for", "normal", "T", "cell", "responsiveness", "and", "is", "often", "impaired", "in", "T", "cells", "during", "aging", ".", "In", "the", "present", "study", ",", "we", "investigated", "whether", "aberrancies", "in", "the", "regulation", "of", "c", "-", "fos", "/", "c", "-", "jun", "at", "the", "mRNA", "or", "protein", "level", "might", "underlie", "the", "age", "-", "associated", "impairments", "of", "AP-1", "in", "human", "T", "cells", ".", "Whereas", "T", "cells", "from", "young", "subjects", "stimulated", "with", "cross", "-", "linked", "anti", "-", "CD3epsilon", "mAb", "OKT3", "plus", "PMA", "or", "with", "the", "lectin", "PHA", "plus", "PMA", "demonstrated", "considerable", "increases", "in", "c", "-", "Fos", "protein", "expression", ",", "the", "expression", "of", "c", "-", "Fos", "but", "not", "c", "-", "Jun", "was", "markedly", "reduced", "in", "stimulated", "T", "cells", "from", "certain", "elderly", "subjects", ".", "In", "addition", ",", "RNase", "protection", "assays", "revealed", "that", "anti", "-", "CD3", "/", "PMA", "-", "stimulated", "T", "cells", "from", "a", "substantial", "proportion", "of", "elderly", "subjects", "exhibited", "decreased", "levels", "of", "c", "-", "fos", "and", "/", "or", "c", "-", "jun", "mRNA", "compared", "to", "T", "cells", "from", "young", "subjects", ".", "Using", "electrophoretic", "mobility", "shift", "assays", ",", "the", "levels", "of", "nuclear", "regulatory", "proteins", "recognizing", "the", "AP-1", "consensus", "TRE", "motif", ",", "the", "proximal", "c", "-", "jun", "TRE", "-", "like", "promoter", "element", ",", "and", "the", "c", "-", "fos", "serum", "response", "element", "(", "SRE", ")", "were", "determined", "in", "resting", "and", "stimulated", "T", "cells", ".", "Although", "the", "stimulation", "of", "T", "cells", "from", "young", "subjects", "resulted", "in", "coordinated", "increases", "of", "nuclear", "protein", "complexes", "binding", "the", "AP-1", "TRE", ",", "c", "-", "jun", "TRE", ",", "and", "c", "-", "fos", "SRE", "DNA", "sequence", "motifs", ",", "age", "-", "related", "reductions", "in", "the", "activation", "of", "AP-1", "were", "accompanied", "by", "decreased", "levels", "of", "c", "-", "jun", "TRE", "and", "c", "-", "fos", "SRE", "binding", "complexes", ".", "Furthermore", ",", "the", "nuclear", "protein", "complexes", "binding", "the", "SRE", "motif", "induced", "in", "activated", "T", "cells", "of", "young", "and", "elderly", "subjects", "contained", "serum", "response", "factor", "and", "Elk-1", "pointing", "toward", "age", "-", "related", "defects", "in", "the", "activation", "of", "transcriptional", "regulatory", "proteins", "distinct", "from", "c", "-", "jun", "/", "AP-1", ".", "These", "results", "suggest", "that", "underlying", "aberrancies", "in", "the", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "as", "well", "as", "their", "nuclear", "regulatory", "proteins", "may", "contribute", "to", "the", "age", "-", "related", "impairments", "of", "AP-1", "activation", "in", "human", "T", "cells", ".", "\n" ]
[ "Entity", "Protein" ]
c - fos, c - jun, c - fos, c - jun, promoter elements, c - Fos, c - Jun, AP-1, c - fos, c - jun, AP-1, CD3epsilon, PHA, c - Fos, c - Fos, c - Jun, CD3, c - fos, c - jun, AP-1 consensus TRE motif, c - jun, TRE - like promoter element, c - fos, serum response element, SRE, nuclear protein complexes, c - jun, c - fos, DNA sequence motifs, AP-1, c - jun, c - fos, binding complexes, nuclear protein complexes, SRE motif, serum response factor, Elk-1, c - jun, / AP-1, c - fos, c - jun, AP-1
196_task2
Sentence: Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O" ]
Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging. In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells. Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects. In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects. Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells. Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes. Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1. These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.
[ "Impaired", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "genes", "and", "of", "transcriptional", "regulatory", "proteins", "binding", "distinct", "c", "-", "fos", "/", "c", "-", "jun", "promoter", "elements", "in", "activated", "human", "T", "cells", "during", "aging", ".", "\n", "The", "activation", "of", "transcriptional", "factor", "c", "-", "Fos", "/", "c", "-", "Jun", "AP-1", "is", "essential", "for", "normal", "T", "cell", "responsiveness", "and", "is", "often", "impaired", "in", "T", "cells", "during", "aging", ".", "In", "the", "present", "study", ",", "we", "investigated", "whether", "aberrancies", "in", "the", "regulation", "of", "c", "-", "fos", "/", "c", "-", "jun", "at", "the", "mRNA", "or", "protein", "level", "might", "underlie", "the", "age", "-", "associated", "impairments", "of", "AP-1", "in", "human", "T", "cells", ".", "Whereas", "T", "cells", "from", "young", "subjects", "stimulated", "with", "cross", "-", "linked", "anti", "-", "CD3epsilon", "mAb", "OKT3", "plus", "PMA", "or", "with", "the", "lectin", "PHA", "plus", "PMA", "demonstrated", "considerable", "increases", "in", "c", "-", "Fos", "protein", "expression", ",", "the", "expression", "of", "c", "-", "Fos", "but", "not", "c", "-", "Jun", "was", "markedly", "reduced", "in", "stimulated", "T", "cells", "from", "certain", "elderly", "subjects", ".", "In", "addition", ",", "RNase", "protection", "assays", "revealed", "that", "anti", "-", "CD3", "/", "PMA", "-", "stimulated", "T", "cells", "from", "a", "substantial", "proportion", "of", "elderly", "subjects", "exhibited", "decreased", "levels", "of", "c", "-", "fos", "and", "/", "or", "c", "-", "jun", "mRNA", "compared", "to", "T", "cells", "from", "young", "subjects", ".", "Using", "electrophoretic", "mobility", "shift", "assays", ",", "the", "levels", "of", "nuclear", "regulatory", "proteins", "recognizing", "the", "AP-1", "consensus", "TRE", "motif", ",", "the", "proximal", "c", "-", "jun", "TRE", "-", "like", "promoter", "element", ",", "and", "the", "c", "-", "fos", "serum", "response", "element", "(", "SRE", ")", "were", "determined", "in", "resting", "and", "stimulated", "T", "cells", ".", "Although", "the", "stimulation", "of", "T", "cells", "from", "young", "subjects", "resulted", "in", "coordinated", "increases", "of", "nuclear", "protein", "complexes", "binding", "the", "AP-1", "TRE", ",", "c", "-", "jun", "TRE", ",", "and", "c", "-", "fos", "SRE", "DNA", "sequence", "motifs", ",", "age", "-", "related", "reductions", "in", "the", "activation", "of", "AP-1", "were", "accompanied", "by", "decreased", "levels", "of", "c", "-", "jun", "TRE", "and", "c", "-", "fos", "SRE", "binding", "complexes", ".", "Furthermore", ",", "the", "nuclear", "protein", "complexes", "binding", "the", "SRE", "motif", "induced", "in", "activated", "T", "cells", "of", "young", "and", "elderly", "subjects", "contained", "serum", "response", "factor", "and", "Elk-1", "pointing", "toward", "age", "-", "related", "defects", "in", "the", "activation", "of", "transcriptional", "regulatory", "proteins", "distinct", "from", "c", "-", "jun", "/", "AP-1", ".", "These", "results", "suggest", "that", "underlying", "aberrancies", "in", "the", "induction", "of", "c", "-", "fos", "/", "c", "-", "jun", "as", "well", "as", "their", "nuclear", "regulatory", "proteins", "may", "contribute", "to", "the", "age", "-", "related", "impairments", "of", "AP-1", "activation", "in", "human", "T", "cells", ".", "\n" ]
[ "Entity", "Protein" ]
analysis is an umlsterm, heart rate is an umlsterm, laboratory is an umlsterm, electrocardiograms is an umlsterm, heart rates is an umlsterm, analog is an umlsterm, tape is an umlsterm, tape recordings is an umlsterm, exhibit is an umlsterm, tape recording is an umlsterm, Methods is an umlsterm, patients is an umlsterm, cardiac disease is an umlsterm, sinus is an umlsterm, Holter monitoring is an umlsterm, patient is an umlsterm, tape is an umlsterm, leads is an umlsterm, analog is an umlsterm, methods is an umlsterm, indices is an umlsterm, power is an umlsterm, power is an umlsterm, power is an umlsterm, indices is an umlsterm, values is an umlsterm, tape is an umlsterm, values is an umlsterm, indices is an umlsterm, standard is an umlsterm, technology is an umlsterm
Herzschrittmachertherapie.00110110.eng.abstr_task0
Sentence: The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders .
[ "The", "accuracy", "of", "the", "RR", "interval", "data", "acquisition", "is", "an", "essential", "prerequisite", "for", "reliable", "analysis", "of", "heart", "rate", "variability", "(", "HRV", ")", ".", "In", "previous", "laboratory", "investigations", ",", "in", "which", "computerized", "electrocardiograms", "were", "simultaneously", "sampled", "at", "identical", "heart", "rates", "using", "digital", "and", "analog", "tape", "recorders", ",", "the", "superiority", "of", "the", "digital", "recorders", "was", "clearly", "demonstrated", ".", "Conventional", "tape", "recordings", "exhibit", "technical", "variability", "which", "may", "produce", "false", "positive", "HRV", "results", ".", "However", ",", "the", "clinical", "significance", "of", "this", "type", "of", "variability", "is", "not", "known", ".", "Aim", "of", "the", "study", ":", "To", "characterize", "the", "clinical", "relevance", "of", "technical", "RR", "variability", "related", "to", "the", "conventional", "tape", "recording", "process", ".", "Methods", ":", "In", "20", "patients", "with", "cardiac", "disease", "and", "stable", "sinus", "rhythm", ",", "24-hour", "Holter", "monitoring", "was", "performed", "by", "connecting", "each", "patient", "simultaneously", "to", "a", "conventional", "tape", "and", "a", "digital", "Holter", "recorder", "(", "Ela", "medical", ")", "via", "the", "same", "leads", ".", "Technical", "variability", "was", "defined", "as", "the", "difference", "between", "the", "HRV", "results", "obtained", "by", "the", "respective", "analog", "(", "A", ")", "and", "digital", "(", "D", ")", "recording", "methods", ".", "Results", ":", "For", "the", "following", "HRV", "indices", "significant", "A", "-", "D", "differences", "were", "found", ":", "SDNNindex", ":", "38.47ms", "(", "A", ")", "vs", ".", "36.17ms", ",", "p=0.003", ";", "RMSSD", ":", "25.04ms", "(", "A", ")", "vs", ".", "21.09ms", "(", "D", ")", ",", "p", "0.001", ";", "pNN50", ":", "3.70", "%", "(", "A", ")", "vs", ".", "2.40", "%", "(", "D", ")", ",", "p=0.006", ";", "Total", "power", ":", "1200.20ms2", "(", "A", ")", "vs", ".", "1076.55ms2", "(", "D", ")", ",", "p=0.032", ";", "LF", "power", ":", "287.35ms2", "(", "A", ")", "vs", ".", "243.80ms2", "(", "D", ")", ",", "p=0.035", ";", "HF", "power", ":", "72.50ms2", "(", "A", ")", "vs", ".", "54.95ms2", "(", "D", ")", ";", "p=0.001", ",", "and", "the", "LF", "/", "HF", "ratio", ":", "4.47", "(", "A", ")", "vs", ".", "5.33", "(", "D", ")", ",", "p=0.037", ".", "No", "significant", "differenes", "were", "found", "for", "the", "following", "indices", ":", "SDNN", ":", "95.59ms", "(", "A", ")", "vs", ".", "94.74ms", "(", "D", ")", ",", "p=0.29", ";", "and", "SDANN", ":", "85.52ms", "(", "A", ")", "vs", ".", "85.08ms", "(", "D", ")", ",", "p=0.68", ".", "Conclusions", ":", "Under", "both", "experimental", "and", "clinical", "conditions", ",", "higher", "HRV", "values", "were", "found", "in", "the", "conventional", "(", "tape", ")", "recordings", ".", "However", ",", "the", "technical", "variability", "was", "small", "in", "comparison", "with", "the", "mean", "values", "of", "normal", "HRV", "indices", "and", "their", "standard", "deviation", ".", "Thus", ",", "differences", "due", "to", "different", "recorder", "technology", "may", "be", "neglected", "in", "clinical", "practice", ".", "Nevertheless", ",", "in", "scientific", "HRV", "trials", ",", "it", "seems", "wise", "to", "use", "digital", "Holter", "recorders", "." ]
[ "umlsterm" ]
analysis is an umlsterm, heart rate is an umlsterm, laboratory is an umlsterm, electrocardiograms is an umlsterm, heart rates is an umlsterm, analog is an umlsterm, tape is an umlsterm, tape recordings is an umlsterm, exhibit is an umlsterm, tape recording is an umlsterm, Methods is an umlsterm, patients is an umlsterm, cardiac disease is an umlsterm, sinus is an umlsterm, Holter monitoring is an umlsterm, patient is an umlsterm, tape is an umlsterm, leads is an umlsterm, analog is an umlsterm, methods is an umlsterm, indices is an umlsterm, power is an umlsterm, power is an umlsterm, power is an umlsterm, indices is an umlsterm, values is an umlsterm, tape is an umlsterm, values is an umlsterm, indices is an umlsterm, standard is an umlsterm, technology is an umlsterm
Herzschrittmachertherapie.00110110.eng.abstr_task1
Sentence: The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders . Instructions: please typing these entity words according to sentence: analysis, heart rate, laboratory, electrocardiograms, heart rates, analog, tape, tape recordings, exhibit, tape recording, Methods, patients, cardiac disease, sinus, Holter monitoring, patient, tape, leads, analog, methods, indices, power, power, power, indices, values, tape, values, indices, standard, technology Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders .
[ "The", "accuracy", "of", "the", "RR", "interval", "data", "acquisition", "is", "an", "essential", "prerequisite", "for", "reliable", "analysis", "of", "heart", "rate", "variability", "(", "HRV", ")", ".", "In", "previous", "laboratory", "investigations", ",", "in", "which", "computerized", "electrocardiograms", "were", "simultaneously", "sampled", "at", "identical", "heart", "rates", "using", "digital", "and", "analog", "tape", "recorders", ",", "the", "superiority", "of", "the", "digital", "recorders", "was", "clearly", "demonstrated", ".", "Conventional", "tape", "recordings", "exhibit", "technical", "variability", "which", "may", "produce", "false", "positive", "HRV", "results", ".", "However", ",", "the", "clinical", "significance", "of", "this", "type", "of", "variability", "is", "not", "known", ".", "Aim", "of", "the", "study", ":", "To", "characterize", "the", "clinical", "relevance", "of", "technical", "RR", "variability", "related", "to", "the", "conventional", "tape", "recording", "process", ".", "Methods", ":", "In", "20", "patients", "with", "cardiac", "disease", "and", "stable", "sinus", "rhythm", ",", "24-hour", "Holter", "monitoring", "was", "performed", "by", "connecting", "each", "patient", "simultaneously", "to", "a", "conventional", "tape", "and", "a", "digital", "Holter", "recorder", "(", "Ela", "medical", ")", "via", "the", "same", "leads", ".", "Technical", "variability", "was", "defined", "as", "the", "difference", "between", "the", "HRV", "results", "obtained", "by", "the", "respective", "analog", "(", "A", ")", "and", "digital", "(", "D", ")", "recording", "methods", ".", "Results", ":", "For", "the", "following", "HRV", "indices", "significant", "A", "-", "D", "differences", "were", "found", ":", "SDNNindex", ":", "38.47ms", "(", "A", ")", "vs", ".", "36.17ms", ",", "p=0.003", ";", "RMSSD", ":", "25.04ms", "(", "A", ")", "vs", ".", "21.09ms", "(", "D", ")", ",", "p", "0.001", ";", "pNN50", ":", "3.70", "%", "(", "A", ")", "vs", ".", "2.40", "%", "(", "D", ")", ",", "p=0.006", ";", "Total", "power", ":", "1200.20ms2", "(", "A", ")", "vs", ".", "1076.55ms2", "(", "D", ")", ",", "p=0.032", ";", "LF", "power", ":", "287.35ms2", "(", "A", ")", "vs", ".", "243.80ms2", "(", "D", ")", ",", "p=0.035", ";", "HF", "power", ":", "72.50ms2", "(", "A", ")", "vs", ".", "54.95ms2", "(", "D", ")", ";", "p=0.001", ",", "and", "the", "LF", "/", "HF", "ratio", ":", "4.47", "(", "A", ")", "vs", ".", "5.33", "(", "D", ")", ",", "p=0.037", ".", "No", "significant", "differenes", "were", "found", "for", "the", "following", "indices", ":", "SDNN", ":", "95.59ms", "(", "A", ")", "vs", ".", "94.74ms", "(", "D", ")", ",", "p=0.29", ";", "and", "SDANN", ":", "85.52ms", "(", "A", ")", "vs", ".", "85.08ms", "(", "D", ")", ",", "p=0.68", ".", "Conclusions", ":", "Under", "both", "experimental", "and", "clinical", "conditions", ",", "higher", "HRV", "values", "were", "found", "in", "the", "conventional", "(", "tape", ")", "recordings", ".", "However", ",", "the", "technical", "variability", "was", "small", "in", "comparison", "with", "the", "mean", "values", "of", "normal", "HRV", "indices", "and", "their", "standard", "deviation", ".", "Thus", ",", "differences", "due", "to", "different", "recorder", "technology", "may", "be", "neglected", "in", "clinical", "practice", ".", "Nevertheless", ",", "in", "scientific", "HRV", "trials", ",", "it", "seems", "wise", "to", "use", "digital", "Holter", "recorders", "." ]
[ "umlsterm" ]
analysis, heart rate, laboratory, electrocardiograms, heart rates, analog, tape, tape recordings, exhibit, tape recording, Methods, patients, cardiac disease, sinus, Holter monitoring, patient, tape, leads, analog, methods, indices, power, power, power, indices, values, tape, values, indices, standard, technology
Herzschrittmachertherapie.00110110.eng.abstr_task2
Sentence: The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The accuracy of the RR interval data acquisition is an essential prerequisite for reliable analysis of heart rate variability ( HRV ) . In previous laboratory investigations , in which computerized electrocardiograms were simultaneously sampled at identical heart rates using digital and analog tape recorders , the superiority of the digital recorders was clearly demonstrated . Conventional tape recordings exhibit technical variability which may produce false positive HRV results . However , the clinical significance of this type of variability is not known . Aim of the study : To characterize the clinical relevance of technical RR variability related to the conventional tape recording process . Methods : In 20 patients with cardiac disease and stable sinus rhythm , 24-hour Holter monitoring was performed by connecting each patient simultaneously to a conventional tape and a digital Holter recorder ( Ela medical ) via the same leads . Technical variability was defined as the difference between the HRV results obtained by the respective analog ( A ) and digital ( D ) recording methods . Results : For the following HRV indices significant A-D differences were found : SDNNindex : 38.47ms ( A ) vs. 36.17ms , p=0.003; RMSSD : 25.04ms ( A ) vs. 21.09ms ( D ) , p 0.001 ; pNN50: 3.70% ( A ) vs. 2.40% ( D ) , p=0.006; Total power : 1200.20ms2 ( A ) vs. 1076.55ms2 ( D ) , p=0.032; LF power : 287.35ms2 ( A ) vs. 243.80ms2 ( D ) , p=0.035; HF power : 72.50ms2 ( A ) vs. 54.95ms2 ( D ) ; p=0.001, and the LF/HF ratio : 4.47 ( A ) vs. 5.33 ( D ) , p=0.037. No significant differenes were found for the following indices : SDNN : 95.59ms ( A ) vs. 94.74ms ( D ) , p=0.29; and SDANN : 85.52ms ( A ) vs. 85.08ms ( D ) , p=0.68. Conclusions : Under both experimental and clinical conditions , higher HRV values were found in the conventional ( tape ) recordings . However , the technical variability was small in comparison with the mean values of normal HRV indices and their standard deviation . Thus , differences due to different recorder technology may be neglected in clinical practice . Nevertheless , in scientific HRV trials , it seems wise to use digital Holter recorders .
[ "The", "accuracy", "of", "the", "RR", "interval", "data", "acquisition", "is", "an", "essential", "prerequisite", "for", "reliable", "analysis", "of", "heart", "rate", "variability", "(", "HRV", ")", ".", "In", "previous", "laboratory", "investigations", ",", "in", "which", "computerized", "electrocardiograms", "were", "simultaneously", "sampled", "at", "identical", "heart", "rates", "using", "digital", "and", "analog", "tape", "recorders", ",", "the", "superiority", "of", "the", "digital", "recorders", "was", "clearly", "demonstrated", ".", "Conventional", "tape", "recordings", "exhibit", "technical", "variability", "which", "may", "produce", "false", "positive", "HRV", "results", ".", "However", ",", "the", "clinical", "significance", "of", "this", "type", "of", "variability", "is", "not", "known", ".", "Aim", "of", "the", "study", ":", "To", "characterize", "the", "clinical", "relevance", "of", "technical", "RR", "variability", "related", "to", "the", "conventional", "tape", "recording", "process", ".", "Methods", ":", "In", "20", "patients", "with", "cardiac", "disease", "and", "stable", "sinus", "rhythm", ",", "24-hour", "Holter", "monitoring", "was", "performed", "by", "connecting", "each", "patient", "simultaneously", "to", "a", "conventional", "tape", "and", "a", "digital", "Holter", "recorder", "(", "Ela", "medical", ")", "via", "the", "same", "leads", ".", "Technical", "variability", "was", "defined", "as", "the", "difference", "between", "the", "HRV", "results", "obtained", "by", "the", "respective", "analog", "(", "A", ")", "and", "digital", "(", "D", ")", "recording", "methods", ".", "Results", ":", "For", "the", "following", "HRV", "indices", "significant", "A", "-", "D", "differences", "were", "found", ":", "SDNNindex", ":", "38.47ms", "(", "A", ")", "vs", ".", "36.17ms", ",", "p=0.003", ";", "RMSSD", ":", "25.04ms", "(", "A", ")", "vs", ".", "21.09ms", "(", "D", ")", ",", "p", "0.001", ";", "pNN50", ":", "3.70", "%", "(", "A", ")", "vs", ".", "2.40", "%", "(", "D", ")", ",", "p=0.006", ";", "Total", "power", ":", "1200.20ms2", "(", "A", ")", "vs", ".", "1076.55ms2", "(", "D", ")", ",", "p=0.032", ";", "LF", "power", ":", "287.35ms2", "(", "A", ")", "vs", ".", "243.80ms2", "(", "D", ")", ",", "p=0.035", ";", "HF", "power", ":", "72.50ms2", "(", "A", ")", "vs", ".", "54.95ms2", "(", "D", ")", ";", "p=0.001", ",", "and", "the", "LF", "/", "HF", "ratio", ":", "4.47", "(", "A", ")", "vs", ".", "5.33", "(", "D", ")", ",", "p=0.037", ".", "No", "significant", "differenes", "were", "found", "for", "the", "following", "indices", ":", "SDNN", ":", "95.59ms", "(", "A", ")", "vs", ".", "94.74ms", "(", "D", ")", ",", "p=0.29", ";", "and", "SDANN", ":", "85.52ms", "(", "A", ")", "vs", ".", "85.08ms", "(", "D", ")", ",", "p=0.68", ".", "Conclusions", ":", "Under", "both", "experimental", "and", "clinical", "conditions", ",", "higher", "HRV", "values", "were", "found", "in", "the", "conventional", "(", "tape", ")", "recordings", ".", "However", ",", "the", "technical", "variability", "was", "small", "in", "comparison", "with", "the", "mean", "values", "of", "normal", "HRV", "indices", "and", "their", "standard", "deviation", ".", "Thus", ",", "differences", "due", "to", "different", "recorder", "technology", "may", "be", "neglected", "in", "clinical", "practice", ".", "Nevertheless", ",", "in", "scientific", "HRV", "trials", ",", "it", "seems", "wise", "to", "use", "digital", "Holter", "recorders", "." ]
[ "umlsterm" ]
central nervous system depressants is a GROUP, benzodiazepines is a GROUP, ROMAZICON is a BRAND, narcotics is a GROUP, anesthetics is a GROUP, muscle relaxants is a GROUP, ROMAZICON is a BRAND, cyclic antidepressants is a GROUP, benzodiazepine is a GROUP, flumazenil is a DRUG, ROMAZICON is a BRAND, ROMAZICON is a BRAND, benzodiazepine is a GROUP, ROMAZICON is a BRAND, benzodiazepines is a GROUP, zopiclone is a DRUG, ROMAZICON is a BRAND, benzodiazepines is a GROUP, flumazenil is a DRUG, ethanol is a DRUG, flumazenil is a DRUG, ROMAZICON is a BRAND, long - acting benzodiazepine is a GROUP, flumazenil is a DRUG, long - acting benzodiazepines is a GROUP, diazepam is a DRUG, short - acting benzodiazepines is a GROUP, midazolam is a DRUG, benzodiazepines is a GROUP, benzodiazepine is a GROUP, alcohol is a DRUG, sedative is a GROUP, ROMAZICON is a BRAND
Flumazenil_ddi_task0
Sentence: Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG, BRAND
[ "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O" ]
Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned.
[ "Interaction", "with", "central", "nervous", "system", "depressants", "other", "than", "benzodiazepines", "has", "not", "been", "specifically", "studied", ";", "however", ",", "no", "deleterious", "interactions", "were", "seen", "when", "ROMAZICON", "was", "administered", "after", "narcotics", ",", "inhalational", "anesthetics", ",", "muscle", "relaxants", "and", "muscle", "relaxant", "antagonists", "administered", "in", "conjunction", "with", "sedation", "or", "anesthesia", ".", "Particular", "caution", "is", "necessary", "when", "using", "ROMAZICON", "in", "cases", "of", "mixed", "drug", "overdosage", "since", "the", "toxic", "effects", "(", "such", "as", "convulsions", "and", "cardiac", "dysrhythmias", ")", "of", "other", "drugs", "taken", "in", "overdose", "(", "especially", "cyclic", "antidepressants", ")", "may", "emerge", "with", "the", "reversal", "of", "the", "benzodiazepine", "effect", "by", "flumazenil", ".", "The", "use", "of", "ROMAZICON", "is", "not", "recommended", "in", "epileptic", "patients", "who", "have", "been", "receiving", "benzodiazepine", "treatment", "for", "a", "prolonged", "period", ".", "Although", "ROMAZICON", "exerts", "a", "slight", "intrinsic", "anticonvulsant", "effect", ",", "its", "abrupt", "suppression", "of", "the", "protective", "effect", "of", "a", "benzodiazepine", "agonist", "can", "give", "rise", "to", "convulsions", "in", "epileptic", "patients", ".", "ROMAZICON", "blocks", "the", "central", "effects", "of", "benzodiazepines", "by", "competitive", "interaction", "at", "the", "receptor", "level", ".", "The", "effects", "of", "nonbenzodiazepine", "agonists", "at", "benzodiazepine", "receptors", ",", "such", "as", "zopiclone", ",", "triazolopyridazines", "and", "others", ",", "are", "also", "blocked", "by", "ROMAZICON", ".", "The", "pharmacokinetics", "of", "benzodiazepines", "are", "unaltered", "in", "the", "presence", "of", "flumazenil", "and", "vice", "versa", ".", "There", "is", "no", "pharmacokinetic", "interaction", "between", "ethanol", "and", "flumazenil", ".", "Use", "in", "Ambulatory", "Patients", "The", "effects", "of", "ROMAZICON", "may", "wear", "off", "before", "a", "long", "-", "acting", "benzodiazepine", "is", "completely", "cleared", "from", "the", "body", ".", "In", "general", ",", "if", "a", "patient", "shows", "no", "signs", "of", "sedation", "within", "2", "hours", "after", "a", "1-mg", "dose", "of", "flumazenil", ",", "serious", "resedation", "at", "a", "later", "time", "is", "unlikely", ".", "An", "adequate", "period", "of", "observation", "must", "be", "provided", "for", "any", "patient", "in", "whom", "either", "long", "-", "acting", "benzodiazepines", "(", "such", "as", "diazepam", ")", "or", "large", "doses", "of", "short", "-", "acting", "benzodiazepines", "(", "such", "as", " ", "10", "mg", "of", "midazolam", ")", "have", "been", "used", ".", "Because", "of", "the", "increased", "risk", "of", "adverse", "reactions", "in", "patients", "who", "have", "been", "taking", "benzodiazepines", "on", "a", "regular", "basis", ",", "it", "is", "particularly", "important", "that", "physicians", "query", "patients", "or", "their", "guardians", "carefully", "about", "benzodiazepine", ",", "alcohol", "and", "sedative", "use", "as", "part", "of", "the", "history", "prior", "to", "any", "procedure", "in", "which", "the", "use", "of", "ROMAZICON", "is", "planned", "." ]
[ "GROUP", "DRUG", "BRAND" ]
central nervous system depressants is a GROUP, benzodiazepines is a GROUP, ROMAZICON is a BRAND, narcotics is a GROUP, anesthetics is a GROUP, muscle relaxants is a GROUP, ROMAZICON is a BRAND, cyclic antidepressants is a GROUP, benzodiazepine is a GROUP, flumazenil is a DRUG, ROMAZICON is a BRAND, ROMAZICON is a BRAND, benzodiazepine is a GROUP, ROMAZICON is a BRAND, benzodiazepines is a GROUP, zopiclone is a DRUG, ROMAZICON is a BRAND, benzodiazepines is a GROUP, flumazenil is a DRUG, ethanol is a DRUG, flumazenil is a DRUG, ROMAZICON is a BRAND, long - acting benzodiazepine is a GROUP, flumazenil is a DRUG, long - acting benzodiazepines is a GROUP, diazepam is a DRUG, short - acting benzodiazepines is a GROUP, midazolam is a DRUG, benzodiazepines is a GROUP, benzodiazepine is a GROUP, alcohol is a DRUG, sedative is a GROUP, ROMAZICON is a BRAND
Flumazenil_ddi_task1
Sentence: Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned. Instructions: please typing these entity words according to sentence: central nervous system depressants, benzodiazepines, ROMAZICON, narcotics, anesthetics, muscle relaxants, ROMAZICON, cyclic antidepressants, benzodiazepine, flumazenil, ROMAZICON, ROMAZICON, benzodiazepine, ROMAZICON, benzodiazepines, zopiclone, ROMAZICON, benzodiazepines, flumazenil, ethanol, flumazenil, ROMAZICON, long - acting benzodiazepine, flumazenil, long - acting benzodiazepines, diazepam, short - acting benzodiazepines, midazolam, benzodiazepines, benzodiazepine, alcohol, sedative, ROMAZICON Options: GROUP, DRUG, BRAND
[ "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O" ]
Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned.
[ "Interaction", "with", "central", "nervous", "system", "depressants", "other", "than", "benzodiazepines", "has", "not", "been", "specifically", "studied", ";", "however", ",", "no", "deleterious", "interactions", "were", "seen", "when", "ROMAZICON", "was", "administered", "after", "narcotics", ",", "inhalational", "anesthetics", ",", "muscle", "relaxants", "and", "muscle", "relaxant", "antagonists", "administered", "in", "conjunction", "with", "sedation", "or", "anesthesia", ".", "Particular", "caution", "is", "necessary", "when", "using", "ROMAZICON", "in", "cases", "of", "mixed", "drug", "overdosage", "since", "the", "toxic", "effects", "(", "such", "as", "convulsions", "and", "cardiac", "dysrhythmias", ")", "of", "other", "drugs", "taken", "in", "overdose", "(", "especially", "cyclic", "antidepressants", ")", "may", "emerge", "with", "the", "reversal", "of", "the", "benzodiazepine", "effect", "by", "flumazenil", ".", "The", "use", "of", "ROMAZICON", "is", "not", "recommended", "in", "epileptic", "patients", "who", "have", "been", "receiving", "benzodiazepine", "treatment", "for", "a", "prolonged", "period", ".", "Although", "ROMAZICON", "exerts", "a", "slight", "intrinsic", "anticonvulsant", "effect", ",", "its", "abrupt", "suppression", "of", "the", "protective", "effect", "of", "a", "benzodiazepine", "agonist", "can", "give", "rise", "to", "convulsions", "in", "epileptic", "patients", ".", "ROMAZICON", "blocks", "the", "central", "effects", "of", "benzodiazepines", "by", "competitive", "interaction", "at", "the", "receptor", "level", ".", "The", "effects", "of", "nonbenzodiazepine", "agonists", "at", "benzodiazepine", "receptors", ",", "such", "as", "zopiclone", ",", "triazolopyridazines", "and", "others", ",", "are", "also", "blocked", "by", "ROMAZICON", ".", "The", "pharmacokinetics", "of", "benzodiazepines", "are", "unaltered", "in", "the", "presence", "of", "flumazenil", "and", "vice", "versa", ".", "There", "is", "no", "pharmacokinetic", "interaction", "between", "ethanol", "and", "flumazenil", ".", "Use", "in", "Ambulatory", "Patients", "The", "effects", "of", "ROMAZICON", "may", "wear", "off", "before", "a", "long", "-", "acting", "benzodiazepine", "is", "completely", "cleared", "from", "the", "body", ".", "In", "general", ",", "if", "a", "patient", "shows", "no", "signs", "of", "sedation", "within", "2", "hours", "after", "a", "1-mg", "dose", "of", "flumazenil", ",", "serious", "resedation", "at", "a", "later", "time", "is", "unlikely", ".", "An", "adequate", "period", "of", "observation", "must", "be", "provided", "for", "any", "patient", "in", "whom", "either", "long", "-", "acting", "benzodiazepines", "(", "such", "as", "diazepam", ")", "or", "large", "doses", "of", "short", "-", "acting", "benzodiazepines", "(", "such", "as", " ", "10", "mg", "of", "midazolam", ")", "have", "been", "used", ".", "Because", "of", "the", "increased", "risk", "of", "adverse", "reactions", "in", "patients", "who", "have", "been", "taking", "benzodiazepines", "on", "a", "regular", "basis", ",", "it", "is", "particularly", "important", "that", "physicians", "query", "patients", "or", "their", "guardians", "carefully", "about", "benzodiazepine", ",", "alcohol", "and", "sedative", "use", "as", "part", "of", "the", "history", "prior", "to", "any", "procedure", "in", "which", "the", "use", "of", "ROMAZICON", "is", "planned", "." ]
[ "GROUP", "DRUG", "BRAND" ]
central nervous system depressants, benzodiazepines, ROMAZICON, narcotics, anesthetics, muscle relaxants, ROMAZICON, cyclic antidepressants, benzodiazepine, flumazenil, ROMAZICON, ROMAZICON, benzodiazepine, ROMAZICON, benzodiazepines, zopiclone, ROMAZICON, benzodiazepines, flumazenil, ethanol, flumazenil, ROMAZICON, long - acting benzodiazepine, flumazenil, long - acting benzodiazepines, diazepam, short - acting benzodiazepines, midazolam, benzodiazepines, benzodiazepine, alcohol, sedative, ROMAZICON
Flumazenil_ddi_task2
Sentence: Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O" ]
Interaction with central nervous system depressants other than benzodiazepines has not been specifically studied; however, no deleterious interactions were seen when ROMAZICON was administered after narcotics, inhalational anesthetics, muscle relaxants and muscle relaxant antagonists administered in conjunction with sedation or anesthesia. Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil. The use of ROMAZICON is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients. ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level. The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa. There is no pharmacokinetic interaction between ethanol and flumazenil. Use in Ambulatory Patients The effects of ROMAZICON may wear off before a long-acting benzodiazepine is completely cleared from the body. In general, if a patient shows no signs of sedation within 2 hours after a 1-mg dose of flumazenil, serious resedation at a later time is unlikely. An adequate period of observation must be provided for any patient in whom either long-acting benzodiazepines (such as diazepam) or large doses of short-acting benzodiazepines (such as 10 mg of midazolam) have been used. Because of the increased risk of adverse reactions in patients who have been taking benzodiazepines on a regular basis, it is particularly important that physicians query patients or their guardians carefully about benzodiazepine, alcohol and sedative use as part of the history prior to any procedure in which the use of ROMAZICON is planned.
[ "Interaction", "with", "central", "nervous", "system", "depressants", "other", "than", "benzodiazepines", "has", "not", "been", "specifically", "studied", ";", "however", ",", "no", "deleterious", "interactions", "were", "seen", "when", "ROMAZICON", "was", "administered", "after", "narcotics", ",", "inhalational", "anesthetics", ",", "muscle", "relaxants", "and", "muscle", "relaxant", "antagonists", "administered", "in", "conjunction", "with", "sedation", "or", "anesthesia", ".", "Particular", "caution", "is", "necessary", "when", "using", "ROMAZICON", "in", "cases", "of", "mixed", "drug", "overdosage", "since", "the", "toxic", "effects", "(", "such", "as", "convulsions", "and", "cardiac", "dysrhythmias", ")", "of", "other", "drugs", "taken", "in", "overdose", "(", "especially", "cyclic", "antidepressants", ")", "may", "emerge", "with", "the", "reversal", "of", "the", "benzodiazepine", "effect", "by", "flumazenil", ".", "The", "use", "of", "ROMAZICON", "is", "not", "recommended", "in", "epileptic", "patients", "who", "have", "been", "receiving", "benzodiazepine", "treatment", "for", "a", "prolonged", "period", ".", "Although", "ROMAZICON", "exerts", "a", "slight", "intrinsic", "anticonvulsant", "effect", ",", "its", "abrupt", "suppression", "of", "the", "protective", "effect", "of", "a", "benzodiazepine", "agonist", "can", "give", "rise", "to", "convulsions", "in", "epileptic", "patients", ".", "ROMAZICON", "blocks", "the", "central", "effects", "of", "benzodiazepines", "by", "competitive", "interaction", "at", "the", "receptor", "level", ".", "The", "effects", "of", "nonbenzodiazepine", "agonists", "at", "benzodiazepine", "receptors", ",", "such", "as", "zopiclone", ",", "triazolopyridazines", "and", "others", ",", "are", "also", "blocked", "by", "ROMAZICON", ".", "The", "pharmacokinetics", "of", "benzodiazepines", "are", "unaltered", "in", "the", "presence", "of", "flumazenil", "and", "vice", "versa", ".", "There", "is", "no", "pharmacokinetic", "interaction", "between", "ethanol", "and", "flumazenil", ".", "Use", "in", "Ambulatory", "Patients", "The", "effects", "of", "ROMAZICON", "may", "wear", "off", "before", "a", "long", "-", "acting", "benzodiazepine", "is", "completely", "cleared", "from", "the", "body", ".", "In", "general", ",", "if", "a", "patient", "shows", "no", "signs", "of", "sedation", "within", "2", "hours", "after", "a", "1-mg", "dose", "of", "flumazenil", ",", "serious", "resedation", "at", "a", "later", "time", "is", "unlikely", ".", "An", "adequate", "period", "of", "observation", "must", "be", "provided", "for", "any", "patient", "in", "whom", "either", "long", "-", "acting", "benzodiazepines", "(", "such", "as", "diazepam", ")", "or", "large", "doses", "of", "short", "-", "acting", "benzodiazepines", "(", "such", "as", " ", "10", "mg", "of", "midazolam", ")", "have", "been", "used", ".", "Because", "of", "the", "increased", "risk", "of", "adverse", "reactions", "in", "patients", "who", "have", "been", "taking", "benzodiazepines", "on", "a", "regular", "basis", ",", "it", "is", "particularly", "important", "that", "physicians", "query", "patients", "or", "their", "guardians", "carefully", "about", "benzodiazepine", ",", "alcohol", "and", "sedative", "use", "as", "part", "of", "the", "history", "prior", "to", "any", "procedure", "in", "which", "the", "use", "of", "ROMAZICON", "is", "planned", "." ]
[ "GROUP", "DRUG", "BRAND" ]
suppressor of cytokine signaling 3 is a protein, SOCS5 is a protein, leucine is a compound, LRIG1 is a protein
DS.d987_task0
Sentence: The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]
The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).
[ "The", "inhibitors", "include", "mitogen", "-", "inducible", "gene-6", "(", "Mig-6)/receptor", "-", "associated", "late", "transducer", "(", "RALT)/Gene", "33", ",", "fibroblast", "growth", "factor", "receptor", "substrate", "2beta", "(", "FRS2beta)/suc1-associated", "neurotrophic", "factor", "target-2", "(", "SNT-2)/FRS3", ",", "suppressor", "of", "cytokine", "signaling", "3", "(", "SOCS3)/SOCS4", "/", "SOCS5", ",", "and", "leucine", "-", "rich", "repeats", "and", "immunoglobulin", "-", "like", "domains", "1", "(", "LRIG1", ")", "." ]
[ "protein", "compound" ]
suppressor of cytokine signaling 3 is a protein, SOCS5 is a protein, leucine is a compound, LRIG1 is a protein
DS.d987_task1
Sentence: The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1). Instructions: please typing these entity words according to sentence: suppressor of cytokine signaling 3, SOCS5, leucine, LRIG1 Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]
The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).
[ "The", "inhibitors", "include", "mitogen", "-", "inducible", "gene-6", "(", "Mig-6)/receptor", "-", "associated", "late", "transducer", "(", "RALT)/Gene", "33", ",", "fibroblast", "growth", "factor", "receptor", "substrate", "2beta", "(", "FRS2beta)/suc1-associated", "neurotrophic", "factor", "target-2", "(", "SNT-2)/FRS3", ",", "suppressor", "of", "cytokine", "signaling", "3", "(", "SOCS3)/SOCS4", "/", "SOCS5", ",", "and", "leucine", "-", "rich", "repeats", "and", "immunoglobulin", "-", "like", "domains", "1", "(", "LRIG1", ")", "." ]
[ "protein", "compound" ]
suppressor of cytokine signaling 3, SOCS5, leucine, LRIG1
DS.d987_task2
Sentence: The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1). Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]
The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).
[ "The", "inhibitors", "include", "mitogen", "-", "inducible", "gene-6", "(", "Mig-6)/receptor", "-", "associated", "late", "transducer", "(", "RALT)/Gene", "33", ",", "fibroblast", "growth", "factor", "receptor", "substrate", "2beta", "(", "FRS2beta)/suc1-associated", "neurotrophic", "factor", "target-2", "(", "SNT-2)/FRS3", ",", "suppressor", "of", "cytokine", "signaling", "3", "(", "SOCS3)/SOCS4", "/", "SOCS5", ",", "and", "leucine", "-", "rich", "repeats", "and", "immunoglobulin", "-", "like", "domains", "1", "(", "LRIG1", ")", "." ]
[ "protein", "compound" ]
developments is an umlsterm, Internet is an umlsterm, World Wide Web is an umlsterm, film is an umlsterm, documentation is an umlsterm
DerRadiologe.70370098.eng.abstr_task0
Sentence: Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated .
[ "Aim", ":", "Recent", "developments", "of", "the", "Internet", "(", "World", "Wide", "Web", ")", "allow", "the", "integration", "of", "audio", ",", "video", ",", "digital", "film", "sequences", ",", "and", "three", "-", "dimensional", "data", ".", "The", "applicability", "of", "these", "innovations", "for", "medical", "documentation", "is", "demonstrated", "." ]
[ "umlsterm" ]
developments is an umlsterm, Internet is an umlsterm, World Wide Web is an umlsterm, film is an umlsterm, documentation is an umlsterm
DerRadiologe.70370098.eng.abstr_task1
Sentence: Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated . Instructions: please typing these entity words according to sentence: developments, Internet, World Wide Web, film, documentation Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated .
[ "Aim", ":", "Recent", "developments", "of", "the", "Internet", "(", "World", "Wide", "Web", ")", "allow", "the", "integration", "of", "audio", ",", "video", ",", "digital", "film", "sequences", ",", "and", "three", "-", "dimensional", "data", ".", "The", "applicability", "of", "these", "innovations", "for", "medical", "documentation", "is", "demonstrated", "." ]
[ "umlsterm" ]
developments, Internet, World Wide Web, film, documentation
DerRadiologe.70370098.eng.abstr_task2
Sentence: Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Aim : Recent developments of the Internet ( World Wide Web ) allow the integration of audio , video , digital film sequences , and three-dimensional data . The applicability of these innovations for medical documentation is demonstrated .
[ "Aim", ":", "Recent", "developments", "of", "the", "Internet", "(", "World", "Wide", "Web", ")", "allow", "the", "integration", "of", "audio", ",", "video", ",", "digital", "film", "sequences", ",", "and", "three", "-", "dimensional", "data", ".", "The", "applicability", "of", "these", "innovations", "for", "medical", "documentation", "is", "demonstrated", "." ]
[ "umlsterm" ]
interleukin-10 is a protein_molecule, human peripheral blood mononuclear cell responses is an other_name, Cryptococcus neoformans is a mono_cell, Candida albicans is a mono_cell, lipopolysaccharide is a lipid
26469_task0
Sentence: Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: mono_cell, other_name, lipid, protein_molecule
[ "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-mono_cell", "I-mono_cell", "O", "B-mono_cell", "I-mono_cell", "O", "O", "B-lipid", "O" ]
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
[ "Effects", "of", "interleukin-10", "on", "human", "peripheral", "blood", "mononuclear", "cell", "responses", "to", "Cryptococcus", "neoformans", ",", "Candida", "albicans", ",", "and", "lipopolysaccharide", "." ]
[ "other_name", "cell_type", "protein_molecule", "protein_family_or_group", "mono_cell", "lipid", "RNA_molecule", "protein_complex" ]
interleukin-10 is a protein_molecule, human peripheral blood mononuclear cell responses is an other_name, Cryptococcus neoformans is a mono_cell, Candida albicans is a mono_cell, lipopolysaccharide is a lipid
26469_task1
Sentence: Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide. Instructions: please typing these entity words according to sentence: interleukin-10, human peripheral blood mononuclear cell responses, Cryptococcus neoformans, Candida albicans, lipopolysaccharide Options: mono_cell, other_name, lipid, protein_molecule
[ "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-mono_cell", "I-mono_cell", "O", "B-mono_cell", "I-mono_cell", "O", "O", "B-lipid", "O" ]
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
[ "Effects", "of", "interleukin-10", "on", "human", "peripheral", "blood", "mononuclear", "cell", "responses", "to", "Cryptococcus", "neoformans", ",", "Candida", "albicans", ",", "and", "lipopolysaccharide", "." ]
[ "other_name", "cell_type", "protein_molecule", "protein_family_or_group", "mono_cell", "lipid", "RNA_molecule", "protein_complex" ]
interleukin-10, human peripheral blood mononuclear cell responses, Cryptococcus neoformans, Candida albicans, lipopolysaccharide
26469_task2
Sentence: Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-mono_cell", "I-mono_cell", "O", "B-mono_cell", "I-mono_cell", "O", "O", "B-lipid", "O" ]
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
[ "Effects", "of", "interleukin-10", "on", "human", "peripheral", "blood", "mononuclear", "cell", "responses", "to", "Cryptococcus", "neoformans", ",", "Candida", "albicans", ",", "and", "lipopolysaccharide", "." ]
[ "other_name", "cell_type", "protein_molecule", "protein_family_or_group", "mono_cell", "lipid", "RNA_molecule", "protein_complex" ]
L - noradrenaline is a CHEMICAL, phenylalanine 4-monooxygenase is a GENE-Y
2226440_task0
Sentence: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]
Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase.
[ "Cooperative", "homotropic", "interaction", "of", "L", "-", "noradrenaline", "with", "the", "catalytic", "site", "of", "phenylalanine", "4-monooxygenase", "." ]
[ "GENE-Y", "CHEMICAL" ]
L - noradrenaline is a CHEMICAL, phenylalanine 4-monooxygenase is a GENE-Y
2226440_task1
Sentence: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Instructions: please typing these entity words according to sentence: L - noradrenaline, phenylalanine 4-monooxygenase Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]
Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase.
[ "Cooperative", "homotropic", "interaction", "of", "L", "-", "noradrenaline", "with", "the", "catalytic", "site", "of", "phenylalanine", "4-monooxygenase", "." ]
[ "GENE-Y", "CHEMICAL" ]
L - noradrenaline, phenylalanine 4-monooxygenase
2226440_task2
Sentence: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]
Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase.
[ "Cooperative", "homotropic", "interaction", "of", "L", "-", "noradrenaline", "with", "the", "catalytic", "site", "of", "phenylalanine", "4-monooxygenase", "." ]
[ "GENE-Y", "CHEMICAL" ]
Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Intensivbetten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm
DerChirurg.70680775.ger.abstr_task0
Sentence: Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden .
[ "Zusammenfassung", ".", "Der", "Risikopatient", "ist", "die", "moderne", "Herausforderung", "an", "den", "Anaesthesiologen", ".", "Besteht", "eine", "chirurgische", "Operationsindikation", ",", "so", "muss", "das", "anaesthesiologische", "Management", "an", "die", "Beduerfnisse", "des", "Patienten", "angepasst", "werden", ".", "Bei", "Risikopatienten", "ist", "generell", "die", "Aufnahme", "in", "einer", "Intensivstation", "sowie", "eine", "Aufenthaltsdauer", "ueber", "den", "3", ".", "postoperativen", "Tag", "hinaus", "zu", "fordern", ".", "Aufgrund", "vieler", "existierender", "Studien", "laesst", "sich", "fuer", "jeden", "Patienten", "und", "fuer", "jede", "Operation", "ein", "individuelles", "Risiko", "ermitteln", ",", "welches", "evtl", ".", "durch", "hausinterne", "Gegebenheiten", ",", "insbesondere", "durch", "das", "Vorhandensein", "postoperativer", "Intensivbetten", "korrigiert", "werden", "kann", ".", "Dieses", "ist", "mit", "der", "durch", "den", "chirurgischen", "Eingriff", "zu", "erwartenden", "Funktionsverbesserung", "in", "Vergleich", "zu", "stellen", "und", "mit", "dem", "Patienten", "bzw", ".", "dessen", "Angehoerigen", "abzusprechen", ".", "Besteht", "allseits", "Uebereinstimmung", "und", "ist", "die", "operative", "Versorgung", "die", "beste", "Behandlungsmethode", ",", "muss", "das", "perioperative", "Management", "in", "allen", "Phasen", "der", "Behandlung", "optimiert", "werden", "." ]
[ "umlsterm" ]
Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Intensivbetten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm
DerChirurg.70680775.ger.abstr_task1
Sentence: Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden . Instructions: please typing these entity words according to sentence: Patienten, Patienten, Risiko, Intensivbetten, Patienten, Behandlung Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden .
[ "Zusammenfassung", ".", "Der", "Risikopatient", "ist", "die", "moderne", "Herausforderung", "an", "den", "Anaesthesiologen", ".", "Besteht", "eine", "chirurgische", "Operationsindikation", ",", "so", "muss", "das", "anaesthesiologische", "Management", "an", "die", "Beduerfnisse", "des", "Patienten", "angepasst", "werden", ".", "Bei", "Risikopatienten", "ist", "generell", "die", "Aufnahme", "in", "einer", "Intensivstation", "sowie", "eine", "Aufenthaltsdauer", "ueber", "den", "3", ".", "postoperativen", "Tag", "hinaus", "zu", "fordern", ".", "Aufgrund", "vieler", "existierender", "Studien", "laesst", "sich", "fuer", "jeden", "Patienten", "und", "fuer", "jede", "Operation", "ein", "individuelles", "Risiko", "ermitteln", ",", "welches", "evtl", ".", "durch", "hausinterne", "Gegebenheiten", ",", "insbesondere", "durch", "das", "Vorhandensein", "postoperativer", "Intensivbetten", "korrigiert", "werden", "kann", ".", "Dieses", "ist", "mit", "der", "durch", "den", "chirurgischen", "Eingriff", "zu", "erwartenden", "Funktionsverbesserung", "in", "Vergleich", "zu", "stellen", "und", "mit", "dem", "Patienten", "bzw", ".", "dessen", "Angehoerigen", "abzusprechen", ".", "Besteht", "allseits", "Uebereinstimmung", "und", "ist", "die", "operative", "Versorgung", "die", "beste", "Behandlungsmethode", ",", "muss", "das", "perioperative", "Management", "in", "allen", "Phasen", "der", "Behandlung", "optimiert", "werden", "." ]
[ "umlsterm" ]
Patienten, Patienten, Risiko, Intensivbetten, Patienten, Behandlung
DerChirurg.70680775.ger.abstr_task2
Sentence: Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Zusammenfassung . Der Risikopatient ist die moderne Herausforderung an den Anaesthesiologen . Besteht eine chirurgische Operationsindikation , so muss das anaesthesiologische Management an die Beduerfnisse des Patienten angepasst werden . Bei Risikopatienten ist generell die Aufnahme in einer Intensivstation sowie eine Aufenthaltsdauer ueber den 3. postoperativen Tag hinaus zu fordern . Aufgrund vieler existierender Studien laesst sich fuer jeden Patienten und fuer jede Operation ein individuelles Risiko ermitteln , welches evtl. durch hausinterne Gegebenheiten , insbesondere durch das Vorhandensein postoperativer Intensivbetten korrigiert werden kann . Dieses ist mit der durch den chirurgischen Eingriff zu erwartenden Funktionsverbesserung in Vergleich zu stellen und mit dem Patienten bzw. dessen Angehoerigen abzusprechen . Besteht allseits Uebereinstimmung und ist die operative Versorgung die beste Behandlungsmethode , muss das perioperative Management in allen Phasen der Behandlung optimiert werden .
[ "Zusammenfassung", ".", "Der", "Risikopatient", "ist", "die", "moderne", "Herausforderung", "an", "den", "Anaesthesiologen", ".", "Besteht", "eine", "chirurgische", "Operationsindikation", ",", "so", "muss", "das", "anaesthesiologische", "Management", "an", "die", "Beduerfnisse", "des", "Patienten", "angepasst", "werden", ".", "Bei", "Risikopatienten", "ist", "generell", "die", "Aufnahme", "in", "einer", "Intensivstation", "sowie", "eine", "Aufenthaltsdauer", "ueber", "den", "3", ".", "postoperativen", "Tag", "hinaus", "zu", "fordern", ".", "Aufgrund", "vieler", "existierender", "Studien", "laesst", "sich", "fuer", "jeden", "Patienten", "und", "fuer", "jede", "Operation", "ein", "individuelles", "Risiko", "ermitteln", ",", "welches", "evtl", ".", "durch", "hausinterne", "Gegebenheiten", ",", "insbesondere", "durch", "das", "Vorhandensein", "postoperativer", "Intensivbetten", "korrigiert", "werden", "kann", ".", "Dieses", "ist", "mit", "der", "durch", "den", "chirurgischen", "Eingriff", "zu", "erwartenden", "Funktionsverbesserung", "in", "Vergleich", "zu", "stellen", "und", "mit", "dem", "Patienten", "bzw", ".", "dessen", "Angehoerigen", "abzusprechen", ".", "Besteht", "allseits", "Uebereinstimmung", "und", "ist", "die", "operative", "Versorgung", "die", "beste", "Behandlungsmethode", ",", "muss", "das", "perioperative", "Management", "in", "allen", "Phasen", "der", "Behandlung", "optimiert", "werden", "." ]
[ "umlsterm" ]
Hypnosis is an umlsterm, autogenic training is an umlsterm, relaxation is an umlsterm, biofeedback is an umlsterm, relaxation - therapy is an umlsterm, techniques is an umlsterm, behavior - therapy is an umlsterm, psychotherapy is an umlsterm, orientation is an umlsterm, meditation is an umlsterm, methodology is an umlsterm, techniques is an umlsterm, relaxation is an umlsterm, patients is an umlsterm, attention is an umlsterm, imagination is an umlsterm, perceptions is an umlsterm, role is an umlsterm, therapeutic is an umlsterm, selfcontrol is an umlsterm, selfesteem is an umlsterm, clinical studies is an umlsterm, psychosomatic disorders is an umlsterm, headache is an umlsterm, pain is an umlsterm, hypertension is an umlsterm, anxiety is an umlsterm, sleeping disorders is an umlsterm, programs is an umlsterm, relaxation is an umlsterm, disorders is an umlsterm, Relaxation therapy is an umlsterm, treatment is an umlsterm, psychiatric disorders is an umlsterm, psychosis is an umlsterm
Psychotherapeut.80430209.eng.abstr_task0
Sentence: Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]
Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis .
[ "Hypnosis", ",", "autogenic", "training", ",", "progressive", "relaxation", "and", "biofeedback", "show", "good", "empirical", "evidence", "concerning", "relaxation", "-", "therapy", "and", "are", "useful", "techniques", "in", "psycho-", "or", "behavior", "-", "therapy", ".", "Though", "they", "share", "some", "aspects", "with", "body", "-", "oriented", "psychotherapy", "these", "relaxation", "-", "techniques", "show", "a", "modern", "scientific", "orientation", "and", "are", "therefore", "to", "seperate", "from", "religious", "meditation", ".", "Though", "in", "details", "somewhat", "different", ",", "the", "methodology", "of", "these", "techniques", "creates", "a", "framework", ",", "in", "which", "the", "psychophysiological", "determined", "relaxation", "response", "is", "easily", "elicited", ".", "However", ",", "regular", "practice", "of", "the", "patients", "is", "requiered", ".", "Focussed", "attention", ",", "imagination", "and", "new", "attributions", "of", "bodily", "or", "mental", "perceptions", "play", "a", "dominant", "role", "concerning", "the", "therapeutic", "effects", ",", "which", "may", "contribute", "to", "enhanced", "internal", "selfcontrol", "and", "selfesteem", ".", "Controlled", "clinical", "studies", "give", "evidence", "to", "positive", "effects", "concerning", "various", "psychosomatic", "disorders", "(", "e.g", ".", "headache", ",", "pain", ",", "ess", ".", "hypertension", ")", ",", "as", "well", "as", "anxiety", "and", "sleeping", "disorders", ".", "As", "components", "of", "psychotherapeutic", "or", "behavioral", "programs", ",", "there", "is", "even", "more", "evidence", "for", "effects", "of", "relaxation", "in", "a", "broad", "spectrum", "of", "disorders", "(", "e.g", ".", "concerning", "addiction", ")", ".", "Relaxation", "therapy", "is", "a", "well", "established", "and", "scientific", "-", "based", "component", "in", "the", "treatment", "of", "psychic", ",", "psychosomatic", "or", "psychiatric", "disorders", ",", "except", "psychosis", "." ]
[ "umlsterm" ]
Hypnosis is an umlsterm, autogenic training is an umlsterm, relaxation is an umlsterm, biofeedback is an umlsterm, relaxation - therapy is an umlsterm, techniques is an umlsterm, behavior - therapy is an umlsterm, psychotherapy is an umlsterm, orientation is an umlsterm, meditation is an umlsterm, methodology is an umlsterm, techniques is an umlsterm, relaxation is an umlsterm, patients is an umlsterm, attention is an umlsterm, imagination is an umlsterm, perceptions is an umlsterm, role is an umlsterm, therapeutic is an umlsterm, selfcontrol is an umlsterm, selfesteem is an umlsterm, clinical studies is an umlsterm, psychosomatic disorders is an umlsterm, headache is an umlsterm, pain is an umlsterm, hypertension is an umlsterm, anxiety is an umlsterm, sleeping disorders is an umlsterm, programs is an umlsterm, relaxation is an umlsterm, disorders is an umlsterm, Relaxation therapy is an umlsterm, treatment is an umlsterm, psychiatric disorders is an umlsterm, psychosis is an umlsterm
Psychotherapeut.80430209.eng.abstr_task1
Sentence: Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis . Instructions: please typing these entity words according to sentence: Hypnosis, autogenic training, relaxation, biofeedback, relaxation - therapy, techniques, behavior - therapy, psychotherapy, orientation, meditation, methodology, techniques, relaxation, patients, attention, imagination, perceptions, role, therapeutic, selfcontrol, selfesteem, clinical studies, psychosomatic disorders, headache, pain, hypertension, anxiety, sleeping disorders, programs, relaxation, disorders, Relaxation therapy, treatment, psychiatric disorders, psychosis Options: umlsterm
[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]
Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis .
[ "Hypnosis", ",", "autogenic", "training", ",", "progressive", "relaxation", "and", "biofeedback", "show", "good", "empirical", "evidence", "concerning", "relaxation", "-", "therapy", "and", "are", "useful", "techniques", "in", "psycho-", "or", "behavior", "-", "therapy", ".", "Though", "they", "share", "some", "aspects", "with", "body", "-", "oriented", "psychotherapy", "these", "relaxation", "-", "techniques", "show", "a", "modern", "scientific", "orientation", "and", "are", "therefore", "to", "seperate", "from", "religious", "meditation", ".", "Though", "in", "details", "somewhat", "different", ",", "the", "methodology", "of", "these", "techniques", "creates", "a", "framework", ",", "in", "which", "the", "psychophysiological", "determined", "relaxation", "response", "is", "easily", "elicited", ".", "However", ",", "regular", "practice", "of", "the", "patients", "is", "requiered", ".", "Focussed", "attention", ",", "imagination", "and", "new", "attributions", "of", "bodily", "or", "mental", "perceptions", "play", "a", "dominant", "role", "concerning", "the", "therapeutic", "effects", ",", "which", "may", "contribute", "to", "enhanced", "internal", "selfcontrol", "and", "selfesteem", ".", "Controlled", "clinical", "studies", "give", "evidence", "to", "positive", "effects", "concerning", "various", "psychosomatic", "disorders", "(", "e.g", ".", "headache", ",", "pain", ",", "ess", ".", "hypertension", ")", ",", "as", "well", "as", "anxiety", "and", "sleeping", "disorders", ".", "As", "components", "of", "psychotherapeutic", "or", "behavioral", "programs", ",", "there", "is", "even", "more", "evidence", "for", "effects", "of", "relaxation", "in", "a", "broad", "spectrum", "of", "disorders", "(", "e.g", ".", "concerning", "addiction", ")", ".", "Relaxation", "therapy", "is", "a", "well", "established", "and", "scientific", "-", "based", "component", "in", "the", "treatment", "of", "psychic", ",", "psychosomatic", "or", "psychiatric", "disorders", ",", "except", "psychosis", "." ]
[ "umlsterm" ]
Hypnosis, autogenic training, relaxation, biofeedback, relaxation - therapy, techniques, behavior - therapy, psychotherapy, orientation, meditation, methodology, techniques, relaxation, patients, attention, imagination, perceptions, role, therapeutic, selfcontrol, selfesteem, clinical studies, psychosomatic disorders, headache, pain, hypertension, anxiety, sleeping disorders, programs, relaxation, disorders, Relaxation therapy, treatment, psychiatric disorders, psychosis
Psychotherapeut.80430209.eng.abstr_task2
Sentence: Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis . Instructions: please extract entity words from the input sentence
[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]
Hypnosis , autogenic training , progressive relaxation and biofeedback show good empirical evidence concerning relaxation-therapy and are useful techniques in psycho- or behavior-therapy . Though they share some aspects with body-oriented psychotherapy these relaxation-techniques show a modern scientific orientation and are therefore to seperate from religious meditation . Though in details somewhat different , the methodology of these techniques creates a framework , in which the psychophysiological determined relaxation response is easily elicited . However , regular practice of the patients is requiered . Focussed attention , imagination and new attributions of bodily or mental perceptions play a dominant role concerning the therapeutic effects , which may contribute to enhanced internal selfcontrol and selfesteem . Controlled clinical studies give evidence to positive effects concerning various psychosomatic disorders ( e.g. headache , pain , ess . hypertension ) , as well as anxiety and sleeping disorders . As components of psychotherapeutic or behavioral programs , there is even more evidence for effects of relaxation in a broad spectrum of disorders ( e.g. concerning addiction ) . Relaxation therapy is a well established and scientific-based component in the treatment of psychic , psychosomatic or psychiatric disorders , except psychosis .
[ "Hypnosis", ",", "autogenic", "training", ",", "progressive", "relaxation", "and", "biofeedback", "show", "good", "empirical", "evidence", "concerning", "relaxation", "-", "therapy", "and", "are", "useful", "techniques", "in", "psycho-", "or", "behavior", "-", "therapy", ".", "Though", "they", "share", "some", "aspects", "with", "body", "-", "oriented", "psychotherapy", "these", "relaxation", "-", "techniques", "show", "a", "modern", "scientific", "orientation", "and", "are", "therefore", "to", "seperate", "from", "religious", "meditation", ".", "Though", "in", "details", "somewhat", "different", ",", "the", "methodology", "of", "these", "techniques", "creates", "a", "framework", ",", "in", "which", "the", "psychophysiological", "determined", "relaxation", "response", "is", "easily", "elicited", ".", "However", ",", "regular", "practice", "of", "the", "patients", "is", "requiered", ".", "Focussed", "attention", ",", "imagination", "and", "new", "attributions", "of", "bodily", "or", "mental", "perceptions", "play", "a", "dominant", "role", "concerning", "the", "therapeutic", "effects", ",", "which", "may", "contribute", "to", "enhanced", "internal", "selfcontrol", "and", "selfesteem", ".", "Controlled", "clinical", "studies", "give", "evidence", "to", "positive", "effects", "concerning", "various", "psychosomatic", "disorders", "(", "e.g", ".", "headache", ",", "pain", ",", "ess", ".", "hypertension", ")", ",", "as", "well", "as", "anxiety", "and", "sleeping", "disorders", ".", "As", "components", "of", "psychotherapeutic", "or", "behavioral", "programs", ",", "there", "is", "even", "more", "evidence", "for", "effects", "of", "relaxation", "in", "a", "broad", "spectrum", "of", "disorders", "(", "e.g", ".", "concerning", "addiction", ")", ".", "Relaxation", "therapy", "is", "a", "well", "established", "and", "scientific", "-", "based", "component", "in", "the", "treatment", "of", "psychic", ",", "psychosomatic", "or", "psychiatric", "disorders", ",", "except", "psychosis", "." ]
[ "umlsterm" ]
placebo - controlled is a Intervention_Control, rhesus - human reassortant rotavirus vaccine is a Intervention_Pharmacological, severe rotavirus gastroenteritis is a Outcome_Physical, efficacy is a Outcome_Other, rhesus - human reassortant rotavirus tetravalent vaccine ( RRV - TV ) is a Intervention_Pharmacological, children is a Participant_Age, Placebo is a Intervention_Control, infants at ages 2 , 3 , and 5 months is a Participant_Age, 2398 is a Participant_Sample-size, RRV - TV vaccine is a Intervention_Pharmacological, young children is a Participant_Age, severe gastroenteritis is a Outcome_Physical
92039_task0
Sentence: Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % .
[ "Randomised", "placebo", "-", "controlled", "trial", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "vaccine", "for", "prevention", "of", "severe", "rotavirus", "gastroenteritis", ".", "BACKGROUND", "Rotavirus", "is", "the", "most", "common", "cause", "of", "acute", "childhood", "gastroenteritis", ".", "Vaccination", "with", "live", "oral", "heterologous", "rotavirus", "vaccines", "may", "prevent", "rotavirus", "gastroenteritis", ".", "We", "assessed", "the", "efficacy", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "tetravalent", "vaccine", "(", "RRV", "-", "TV", ")", "against", "severe", "rotavirus", "gastroenteritis", "in", "Finnish", "children", "in", "a", "randomised", "placebo", "-", "controlled", "double", "-", "blind", "trial", ".", "METHODS", "Placebo", "or", "RRV", "-", "TV", "(", "titre", "4x10", "(", "5", ")", "plaque", "-", "forming", "units", ")", "was", "given", "to", "infants", "at", "ages", "2", ",", "3", ",", "and", "5", "months", ".", "The", "children", "were", "followed", "up", "for", "one", "or", "two", "rotavirus", "epidemic", "seasons", ".", "The", "main", "outcome", "measure", "was", "protection", "against", "severe", "rotavirus", "gastroenteritis", "(", "score", ">", "or", "=", "11", "on", "a", "20-point", "severity", "scale", ")", ".", "2398", "children", "were", "enrolled", "and", "received", "at", "least", "one", "dose", "of", "RRV", "-", "TV", "(", "n=1191", ")", "or", "placebo", "(", "n=1207", ")", ".", "The", "primary", "efficacy", "analysis", "was", "based", "on", "children", "who", "received", "three", "doses", "of", "RRV", "-", "TV", "(", "n=1128", ")", "or", "placebo", "(", "n=1145", ")", ".", "FINDINGS", "256", "episodes", "of", "rotavirus", "gastroenteritis", "occurred", "at", "any", "time", "during", "the", "study", ";", "65", "were", "among", "1191", "RRV", "-", "TV", "recipients", ",", "and", "191", "among", "1207", "placebo", "recipients", "(", "vaccine", "efficacy", "66", "%", "[", "95", "%", "CI", "55", "-", "74", "]", ";", "intention", "-", "to", "-", "treat", "analysis", ")", ".", "226", "episodes", "were", "included", "in", "the", "primary", "efficacy", "analysis", "of", "fully", "vaccinated", "children", "(", "54", "among", "1128", "RRV", "-", "TV", "recipients", ",", "172", "among", "1145", "placebo", "recipients", ";", "vaccine", "efficacy", "68", "%", "[", "57", "-", "76", "]", ")", ".", "100", "episodes", "were", "severe", ",", "eight", "in", "RRV", "-", "TV", "recipients", "and", "92", "in", "placebo", "recipients", "(", "vaccine", "efficacy", "91", "%", "[", "82", "-", "96", "]", ")", ".", "INTERPRETATION", "RRV", "-", "TV", "vaccine", "was", "highly", "effective", "against", "severe", "rotavirus", "gastroenteritis", "in", "young", "children", ".", "Incorporation", "of", "this", "vaccine", "into", "routine", "immunisation", "schedules", "of", "infants", "could", "reduce", "severe", "rotavirus", "gastroenteritis", "by", "90", "%", "and", "severe", "gastroenteritis", "of", "all", "causes", "in", "young", "children", "by", "60", "%", "." ]
[ "Intervention_Pharmacological", "Participant_Age", "Outcome_Physical", "Intervention_Control", "Outcome_Other", "Participant_Sample-size" ]
placebo - controlled is a Intervention_Control, rhesus - human reassortant rotavirus vaccine is a Intervention_Pharmacological, severe rotavirus gastroenteritis is a Outcome_Physical, efficacy is a Outcome_Other, rhesus - human reassortant rotavirus tetravalent vaccine ( RRV - TV ) is a Intervention_Pharmacological, children is a Participant_Age, Placebo is a Intervention_Control, infants at ages 2 , 3 , and 5 months is a Participant_Age, 2398 is a Participant_Sample-size, RRV - TV vaccine is a Intervention_Pharmacological, young children is a Participant_Age, severe gastroenteritis is a Outcome_Physical
92039_task1
Sentence: Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % . Instructions: please typing these entity words according to sentence: placebo - controlled, rhesus - human reassortant rotavirus vaccine, severe rotavirus gastroenteritis, efficacy, rhesus - human reassortant rotavirus tetravalent vaccine ( RRV - TV ), children, Placebo, infants at ages 2 , 3 , and 5 months, 2398, RRV - TV vaccine, young children, severe gastroenteritis Options: Intervention_Pharmacological, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % .
[ "Randomised", "placebo", "-", "controlled", "trial", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "vaccine", "for", "prevention", "of", "severe", "rotavirus", "gastroenteritis", ".", "BACKGROUND", "Rotavirus", "is", "the", "most", "common", "cause", "of", "acute", "childhood", "gastroenteritis", ".", "Vaccination", "with", "live", "oral", "heterologous", "rotavirus", "vaccines", "may", "prevent", "rotavirus", "gastroenteritis", ".", "We", "assessed", "the", "efficacy", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "tetravalent", "vaccine", "(", "RRV", "-", "TV", ")", "against", "severe", "rotavirus", "gastroenteritis", "in", "Finnish", "children", "in", "a", "randomised", "placebo", "-", "controlled", "double", "-", "blind", "trial", ".", "METHODS", "Placebo", "or", "RRV", "-", "TV", "(", "titre", "4x10", "(", "5", ")", "plaque", "-", "forming", "units", ")", "was", "given", "to", "infants", "at", "ages", "2", ",", "3", ",", "and", "5", "months", ".", "The", "children", "were", "followed", "up", "for", "one", "or", "two", "rotavirus", "epidemic", "seasons", ".", "The", "main", "outcome", "measure", "was", "protection", "against", "severe", "rotavirus", "gastroenteritis", "(", "score", ">", "or", "=", "11", "on", "a", "20-point", "severity", "scale", ")", ".", "2398", "children", "were", "enrolled", "and", "received", "at", "least", "one", "dose", "of", "RRV", "-", "TV", "(", "n=1191", ")", "or", "placebo", "(", "n=1207", ")", ".", "The", "primary", "efficacy", "analysis", "was", "based", "on", "children", "who", "received", "three", "doses", "of", "RRV", "-", "TV", "(", "n=1128", ")", "or", "placebo", "(", "n=1145", ")", ".", "FINDINGS", "256", "episodes", "of", "rotavirus", "gastroenteritis", "occurred", "at", "any", "time", "during", "the", "study", ";", "65", "were", "among", "1191", "RRV", "-", "TV", "recipients", ",", "and", "191", "among", "1207", "placebo", "recipients", "(", "vaccine", "efficacy", "66", "%", "[", "95", "%", "CI", "55", "-", "74", "]", ";", "intention", "-", "to", "-", "treat", "analysis", ")", ".", "226", "episodes", "were", "included", "in", "the", "primary", "efficacy", "analysis", "of", "fully", "vaccinated", "children", "(", "54", "among", "1128", "RRV", "-", "TV", "recipients", ",", "172", "among", "1145", "placebo", "recipients", ";", "vaccine", "efficacy", "68", "%", "[", "57", "-", "76", "]", ")", ".", "100", "episodes", "were", "severe", ",", "eight", "in", "RRV", "-", "TV", "recipients", "and", "92", "in", "placebo", "recipients", "(", "vaccine", "efficacy", "91", "%", "[", "82", "-", "96", "]", ")", ".", "INTERPRETATION", "RRV", "-", "TV", "vaccine", "was", "highly", "effective", "against", "severe", "rotavirus", "gastroenteritis", "in", "young", "children", ".", "Incorporation", "of", "this", "vaccine", "into", "routine", "immunisation", "schedules", "of", "infants", "could", "reduce", "severe", "rotavirus", "gastroenteritis", "by", "90", "%", "and", "severe", "gastroenteritis", "of", "all", "causes", "in", "young", "children", "by", "60", "%", "." ]
[ "Intervention_Pharmacological", "Participant_Age", "Outcome_Physical", "Intervention_Control", "Outcome_Other", "Participant_Sample-size" ]
placebo - controlled, rhesus - human reassortant rotavirus vaccine, severe rotavirus gastroenteritis, efficacy, rhesus - human reassortant rotavirus tetravalent vaccine ( RRV - TV ), children, Placebo, infants at ages 2 , 3 , and 5 months, 2398, RRV - TV vaccine, young children, severe gastroenteritis
92039_task2
Sentence: Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % . Instructions: please extract entity words from the input sentence
[ "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis . BACKGROUND Rotavirus is the most common cause of acute childhood gastroenteritis . Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis . We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine ( RRV-TV ) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial . METHODS Placebo or RRV-TV ( titre 4x10 ( 5 ) plaque-forming units ) was given to infants at ages 2 , 3 , and 5 months . The children were followed up for one or two rotavirus epidemic seasons . The main outcome measure was protection against severe rotavirus gastroenteritis ( score > or =11 on a 20-point severity scale ) . 2398 children were enrolled and received at least one dose of RRV-TV ( n=1191 ) or placebo ( n=1207 ) . The primary efficacy analysis was based on children who received three doses of RRV-TV ( n=1128 ) or placebo ( n=1145 ) . FINDINGS 256 episodes of rotavirus gastroenteritis occurred at any time during the study ; 65 were among 1191 RRV-TV recipients , and 191 among 1207 placebo recipients ( vaccine efficacy 66 % [ 95 % CI 55-74 ] ; intention-to-treat analysis ) . 226 episodes were included in the primary efficacy analysis of fully vaccinated children ( 54 among 1128 RRV-TV recipients , 172 among 1145 placebo recipients ; vaccine efficacy 68 % [ 57-76 ] ) . 100 episodes were severe , eight in RRV-TV recipients and 92 in placebo recipients ( vaccine efficacy 91 % [ 82-96 ] ) . INTERPRETATION RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children . Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90 % and severe gastroenteritis of all causes in young children by 60 % .
[ "Randomised", "placebo", "-", "controlled", "trial", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "vaccine", "for", "prevention", "of", "severe", "rotavirus", "gastroenteritis", ".", "BACKGROUND", "Rotavirus", "is", "the", "most", "common", "cause", "of", "acute", "childhood", "gastroenteritis", ".", "Vaccination", "with", "live", "oral", "heterologous", "rotavirus", "vaccines", "may", "prevent", "rotavirus", "gastroenteritis", ".", "We", "assessed", "the", "efficacy", "of", "rhesus", "-", "human", "reassortant", "rotavirus", "tetravalent", "vaccine", "(", "RRV", "-", "TV", ")", "against", "severe", "rotavirus", "gastroenteritis", "in", "Finnish", "children", "in", "a", "randomised", "placebo", "-", "controlled", "double", "-", "blind", "trial", ".", "METHODS", "Placebo", "or", "RRV", "-", "TV", "(", "titre", "4x10", "(", "5", ")", "plaque", "-", "forming", "units", ")", "was", "given", "to", "infants", "at", "ages", "2", ",", "3", ",", "and", "5", "months", ".", "The", "children", "were", "followed", "up", "for", "one", "or", "two", "rotavirus", "epidemic", "seasons", ".", "The", "main", "outcome", "measure", "was", "protection", "against", "severe", "rotavirus", "gastroenteritis", "(", "score", ">", "or", "=", "11", "on", "a", "20-point", "severity", "scale", ")", ".", "2398", "children", "were", "enrolled", "and", "received", "at", "least", "one", "dose", "of", "RRV", "-", "TV", "(", "n=1191", ")", "or", "placebo", "(", "n=1207", ")", ".", "The", "primary", "efficacy", "analysis", "was", "based", "on", "children", "who", "received", "three", "doses", "of", "RRV", "-", "TV", "(", "n=1128", ")", "or", "placebo", "(", "n=1145", ")", ".", "FINDINGS", "256", "episodes", "of", "rotavirus", "gastroenteritis", "occurred", "at", "any", "time", "during", "the", "study", ";", "65", "were", "among", "1191", "RRV", "-", "TV", "recipients", ",", "and", "191", "among", "1207", "placebo", "recipients", "(", "vaccine", "efficacy", "66", "%", "[", "95", "%", "CI", "55", "-", "74", "]", ";", "intention", "-", "to", "-", "treat", "analysis", ")", ".", "226", "episodes", "were", "included", "in", "the", "primary", "efficacy", "analysis", "of", "fully", "vaccinated", "children", "(", "54", "among", "1128", "RRV", "-", "TV", "recipients", ",", "172", "among", "1145", "placebo", "recipients", ";", "vaccine", "efficacy", "68", "%", "[", "57", "-", "76", "]", ")", ".", "100", "episodes", "were", "severe", ",", "eight", "in", "RRV", "-", "TV", "recipients", "and", "92", "in", "placebo", "recipients", "(", "vaccine", "efficacy", "91", "%", "[", "82", "-", "96", "]", ")", ".", "INTERPRETATION", "RRV", "-", "TV", "vaccine", "was", "highly", "effective", "against", "severe", "rotavirus", "gastroenteritis", "in", "young", "children", ".", "Incorporation", "of", "this", "vaccine", "into", "routine", "immunisation", "schedules", "of", "infants", "could", "reduce", "severe", "rotavirus", "gastroenteritis", "by", "90", "%", "and", "severe", "gastroenteritis", "of", "all", "causes", "in", "young", "children", "by", "60", "%", "." ]
[ "Intervention_Pharmacological", "Participant_Age", "Outcome_Physical", "Intervention_Control", "Outcome_Other", "Participant_Sample-size" ]
Respiratorische Stoerungen is an umlsterm, Beurteilung is an umlsterm, Techniken is an umlsterm
MonatsschriftKinderheilkunde.81461026.ger.abstr_task0
Sentence: Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden .
[ "Respiratorische", "Stoerungen", "zaehlen", "zu", "den", "haeufigsten", "Krankheitsmanifestationen", "im", "Saeuglingsalter", ".", "Zur", "Beurteilung", "respiratorischer", "Erkrankungen", "kann", "die", "Lungenfunktionsdiagnostik", "einen", "wesentlichen", "Beitrag", "leisten", ".", "Zu", "diesem", "Zweck", "mussten", "fuer", "dieses", "Lebensalter", "aber", "erst", "entsprechende", "Techniken", "entwickelt", "werden", "." ]
[ "umlsterm" ]
Respiratorische Stoerungen is an umlsterm, Beurteilung is an umlsterm, Techniken is an umlsterm
MonatsschriftKinderheilkunde.81461026.ger.abstr_task1
Sentence: Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden . Instructions: please typing these entity words according to sentence: Respiratorische Stoerungen, Beurteilung, Techniken Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden .
[ "Respiratorische", "Stoerungen", "zaehlen", "zu", "den", "haeufigsten", "Krankheitsmanifestationen", "im", "Saeuglingsalter", ".", "Zur", "Beurteilung", "respiratorischer", "Erkrankungen", "kann", "die", "Lungenfunktionsdiagnostik", "einen", "wesentlichen", "Beitrag", "leisten", ".", "Zu", "diesem", "Zweck", "mussten", "fuer", "dieses", "Lebensalter", "aber", "erst", "entsprechende", "Techniken", "entwickelt", "werden", "." ]
[ "umlsterm" ]
Respiratorische Stoerungen, Beurteilung, Techniken
MonatsschriftKinderheilkunde.81461026.ger.abstr_task2
Sentence: Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden . Instructions: please extract entity words from the input sentence
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Respiratorische Stoerungen zaehlen zu den haeufigsten Krankheitsmanifestationen im Saeuglingsalter . Zur Beurteilung respiratorischer Erkrankungen kann die Lungenfunktionsdiagnostik einen wesentlichen Beitrag leisten . Zu diesem Zweck mussten fuer dieses Lebensalter aber erst entsprechende Techniken entwickelt werden .
[ "Respiratorische", "Stoerungen", "zaehlen", "zu", "den", "haeufigsten", "Krankheitsmanifestationen", "im", "Saeuglingsalter", ".", "Zur", "Beurteilung", "respiratorischer", "Erkrankungen", "kann", "die", "Lungenfunktionsdiagnostik", "einen", "wesentlichen", "Beitrag", "leisten", ".", "Zu", "diesem", "Zweck", "mussten", "fuer", "dieses", "Lebensalter", "aber", "erst", "entsprechende", "Techniken", "entwickelt", "werden", "." ]
[ "umlsterm" ]
Efficacy is a Outcome_Other, barrier cream is a Intervention_Physical, its vehicle is a Intervention_Physical, occupational irritant contact dermatitis is a Outcome_Physical, barrier creams is a Intervention_Pharmacological, skin compatibility , efficacy and resulting acceptance is a Outcome_Physical, 2 panels is a Participant_Sample-size, 25 hospital is a Participant_Sample-size, skin irritation is a Participant_Condition, verum or vehicle ) over a period of 4 weeks is a Intervention_Physical, clinical skin status is a Outcome_Physical, stratum corneum hydration is a Outcome_Physical, tolerated is a Outcome_Other, and accepted well is a Outcome_Physical, skin protection and skin care . is a Outcome_Physical
2967_task0
Sentence: Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Outcome_Other", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective .
[ "Efficacy", "of", "a", "barrier", "cream", "and", "its", "vehicle", "as", "protective", "measures", "against", "occupational", "irritant", "contact", "dermatitis", ".", "The", "actual", "advantage", "of", "barrier", "creams", "over", "bland", "emollients", "for", "skin", "protection", "is", "still", "hotly", "debated", ".", "In", "a", "randomized", ",", "double", "-", "blinded", "study", ",", "a", "newly", "-", "introduced", "barrier", "cream", "and", "its", "moisturizing", "vehicle", "were", "compared", "regarding", "their", "skin", "compatibility", ",", "efficacy", "and", "resulting", "acceptance", ".", "Thus", ",", "2", "panels", "of", "25", "hospital", "nurses", "with", "mild", "signs", "of", "skin", "irritation", "were", "asked", "to", "use", "1", "of", "the", "test", "products", "provided", "(", "verum", "or", "vehicle", ")", "over", "a", "period", "of", "4", "weeks", ".", "Effects", "of", "both", "types", "of", "preparations", "were", "studied", "weekly", "by", "clinical", "examination", "and", "the", "instrumental", "assessment", "of", "bioengineering", "parameters", ".", "Results", "showed", "no", "significant", "differences", "between", "barrier", "cream", "and", "vehicle", ".", "In", "both", "groups", ",", "clinical", "skin", "status", "improved", "and", "stratum", "corneum", "hydration", "increased", "significantly", "during", "the", "study", "period", ".", "Both", "preparations", "were", "tolerated", "and", "accepted", "well", ",", "thus", "showing", "both", "skin", "protection", "and", "skin", "care", ".", "These", "results", "contribute", "to", "the", "debate", "as", "to", "whether", "a", "strict", "distinction", "between", "\"", "skin", "care", "\"", "and", "\"", "skin", "protection", "\"", "products", "is", "justified", ".", "The", "vehicle", "alone", "is", "capable", "of", "positively", "influencing", "skin", "status", ".", "Emphasis", "must", "be", "laid", "on", "regular", ",", "frequent", ",", "and", "correct", "application", "of", "a", "product", "for", "it", "to", "be", "effective", "." ]
[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size", "Outcome_Other" ]
Efficacy is a Outcome_Other, barrier cream is a Intervention_Physical, its vehicle is a Intervention_Physical, occupational irritant contact dermatitis is a Outcome_Physical, barrier creams is a Intervention_Pharmacological, skin compatibility , efficacy and resulting acceptance is a Outcome_Physical, 2 panels is a Participant_Sample-size, 25 hospital is a Participant_Sample-size, skin irritation is a Participant_Condition, verum or vehicle ) over a period of 4 weeks is a Intervention_Physical, clinical skin status is a Outcome_Physical, stratum corneum hydration is a Outcome_Physical, tolerated is a Outcome_Other, and accepted well is a Outcome_Physical, skin protection and skin care . is a Outcome_Physical
2967_task1
Sentence: Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective . Instructions: please typing these entity words according to sentence: Efficacy, barrier cream, its vehicle, occupational irritant contact dermatitis, barrier creams, skin compatibility , efficacy and resulting acceptance, 2 panels, 25 hospital, skin irritation, verum or vehicle ) over a period of 4 weeks, clinical skin status, stratum corneum hydration, tolerated, and accepted well, skin protection and skin care . Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Outcome_Other", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective .
[ "Efficacy", "of", "a", "barrier", "cream", "and", "its", "vehicle", "as", "protective", "measures", "against", "occupational", "irritant", "contact", "dermatitis", ".", "The", "actual", "advantage", "of", "barrier", "creams", "over", "bland", "emollients", "for", "skin", "protection", "is", "still", "hotly", "debated", ".", "In", "a", "randomized", ",", "double", "-", "blinded", "study", ",", "a", "newly", "-", "introduced", "barrier", "cream", "and", "its", "moisturizing", "vehicle", "were", "compared", "regarding", "their", "skin", "compatibility", ",", "efficacy", "and", "resulting", "acceptance", ".", "Thus", ",", "2", "panels", "of", "25", "hospital", "nurses", "with", "mild", "signs", "of", "skin", "irritation", "were", "asked", "to", "use", "1", "of", "the", "test", "products", "provided", "(", "verum", "or", "vehicle", ")", "over", "a", "period", "of", "4", "weeks", ".", "Effects", "of", "both", "types", "of", "preparations", "were", "studied", "weekly", "by", "clinical", "examination", "and", "the", "instrumental", "assessment", "of", "bioengineering", "parameters", ".", "Results", "showed", "no", "significant", "differences", "between", "barrier", "cream", "and", "vehicle", ".", "In", "both", "groups", ",", "clinical", "skin", "status", "improved", "and", "stratum", "corneum", "hydration", "increased", "significantly", "during", "the", "study", "period", ".", "Both", "preparations", "were", "tolerated", "and", "accepted", "well", ",", "thus", "showing", "both", "skin", "protection", "and", "skin", "care", ".", "These", "results", "contribute", "to", "the", "debate", "as", "to", "whether", "a", "strict", "distinction", "between", "\"", "skin", "care", "\"", "and", "\"", "skin", "protection", "\"", "products", "is", "justified", ".", "The", "vehicle", "alone", "is", "capable", "of", "positively", "influencing", "skin", "status", ".", "Emphasis", "must", "be", "laid", "on", "regular", ",", "frequent", ",", "and", "correct", "application", "of", "a", "product", "for", "it", "to", "be", "effective", "." ]
[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size", "Outcome_Other" ]
Efficacy, barrier cream, its vehicle, occupational irritant contact dermatitis, barrier creams, skin compatibility , efficacy and resulting acceptance, 2 panels, 25 hospital, skin irritation, verum or vehicle ) over a period of 4 weeks, clinical skin status, stratum corneum hydration, tolerated, and accepted well, skin protection and skin care .
2967_task2
Sentence: Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective . Instructions: please extract entity words from the input sentence
[ "B-Outcome_Other", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective .
[ "Efficacy", "of", "a", "barrier", "cream", "and", "its", "vehicle", "as", "protective", "measures", "against", "occupational", "irritant", "contact", "dermatitis", ".", "The", "actual", "advantage", "of", "barrier", "creams", "over", "bland", "emollients", "for", "skin", "protection", "is", "still", "hotly", "debated", ".", "In", "a", "randomized", ",", "double", "-", "blinded", "study", ",", "a", "newly", "-", "introduced", "barrier", "cream", "and", "its", "moisturizing", "vehicle", "were", "compared", "regarding", "their", "skin", "compatibility", ",", "efficacy", "and", "resulting", "acceptance", ".", "Thus", ",", "2", "panels", "of", "25", "hospital", "nurses", "with", "mild", "signs", "of", "skin", "irritation", "were", "asked", "to", "use", "1", "of", "the", "test", "products", "provided", "(", "verum", "or", "vehicle", ")", "over", "a", "period", "of", "4", "weeks", ".", "Effects", "of", "both", "types", "of", "preparations", "were", "studied", "weekly", "by", "clinical", "examination", "and", "the", "instrumental", "assessment", "of", "bioengineering", "parameters", ".", "Results", "showed", "no", "significant", "differences", "between", "barrier", "cream", "and", "vehicle", ".", "In", "both", "groups", ",", "clinical", "skin", "status", "improved", "and", "stratum", "corneum", "hydration", "increased", "significantly", "during", "the", "study", "period", ".", "Both", "preparations", "were", "tolerated", "and", "accepted", "well", ",", "thus", "showing", "both", "skin", "protection", "and", "skin", "care", ".", "These", "results", "contribute", "to", "the", "debate", "as", "to", "whether", "a", "strict", "distinction", "between", "\"", "skin", "care", "\"", "and", "\"", "skin", "protection", "\"", "products", "is", "justified", ".", "The", "vehicle", "alone", "is", "capable", "of", "positively", "influencing", "skin", "status", ".", "Emphasis", "must", "be", "laid", "on", "regular", ",", "frequent", ",", "and", "correct", "application", "of", "a", "product", "for", "it", "to", "be", "effective", "." ]
[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size", "Outcome_Other" ]
p53 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, ubiquitin is a Protein, MDM2 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, CHIP is a Protein, carboxy terminus of Hsp70-interacting protein is a Protein, CHIP is a Protein, CHIP is a Protein, p53 is a Protein, CHIP is a Protein, p53 is a Protein
297_task0
Sentence: Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
[ "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers.
[ "Chaperone", "-", "dependent", "stabilization", "and", "degradation", "of", "p53", "mutants", ".", "\n", "p53", "missense", "mutant", "proteins", "commonly", "show", "increased", "stability", "compared", "to", "wild", "-", "type", "p53", ",", "which", "is", "thought", "to", "depend", "largely", "on", "the", "inability", "of", "mutant", "p53", "to", "induce", "the", "ubiquitin", "ligase", "MDM2", ".", "However", ",", "recent", "work", "using", "mouse", "models", "has", "shown", "that", "the", "accumulation", "of", "mutant", "p53", "occurs", "only", "in", "tumour", "cells", ",", "indicating", "that", "stabilization", "requires", "additional", "factors", ".", "To", "clarify", "the", "stabilization", "of", "p53", "mutants", "in", "tumours", ",", "we", "analysed", "factors", "that", "affect", "their", "folding", "and", "degradation", ".", "Although", "all", "missense", "mutants", "that", "we", "studied", "are", "more", "stable", "than", "wild", "-", "type", "p53", ",", "the", "levels", "correlate", "with", "individual", "structural", "characteristics", ",", "which", "may", "be", "reflected", "in", "different", "gain", "-", "of", "-", "function", "properties", ".", "In", "the", "absence", "of", "Hsp90", "activity", ",", "the", "less", "stable", "unfolded", "p53", "mutants", "preferentially", "associate", "in", "a", "complex", "with", "Hsp70", "and", "CHIP", "(", "carboxy", "terminus", "of", "Hsp70-interacting", "protein", ")", ",", "and", "we", "show", "that", "CHIP", "is", "responsible", "for", "ubiquitination", "and", "degradation", "of", "these", "mutants", ".", "The", "demonstration", "of", "a", "complex", "interplay", "between", "Hsp90", ",", "Hsp70", "and", "CHIP", "that", "regulate", "the", "stability", "of", "different", "p53", "mutant", "proteins", "improves", "our", "understanding", "of", "the", "pro", "-", "tumorigenic", "effects", "of", "increased", "Hsp90", "activity", "during", "multi", "-", "stage", "carcinogenesis", ".", "Understanding", "the", "roles", "of", "Hsp90", ",", "Hsp70", "and", "CHIP", "in", "cancers", "may", "also", "provide", "an", "important", "avenue", "through", "which", "to", "target", "p53", "to", "enhance", "treatment", "of", "human", "cancers", ".", "\n" ]
[ "Protein" ]
p53 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, ubiquitin is a Protein, MDM2 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, p53 is a Protein, CHIP is a Protein, carboxy terminus of Hsp70-interacting protein is a Protein, CHIP is a Protein, CHIP is a Protein, p53 is a Protein, CHIP is a Protein, p53 is a Protein
297_task1
Sentence: Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers. Instructions: please typing these entity words according to sentence: p53, p53, p53, p53, ubiquitin, MDM2, p53, p53, p53, p53, CHIP, carboxy terminus of Hsp70-interacting protein, CHIP, CHIP, p53, CHIP, p53 Options: Protein
[ "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers.
[ "Chaperone", "-", "dependent", "stabilization", "and", "degradation", "of", "p53", "mutants", ".", "\n", "p53", "missense", "mutant", "proteins", "commonly", "show", "increased", "stability", "compared", "to", "wild", "-", "type", "p53", ",", "which", "is", "thought", "to", "depend", "largely", "on", "the", "inability", "of", "mutant", "p53", "to", "induce", "the", "ubiquitin", "ligase", "MDM2", ".", "However", ",", "recent", "work", "using", "mouse", "models", "has", "shown", "that", "the", "accumulation", "of", "mutant", "p53", "occurs", "only", "in", "tumour", "cells", ",", "indicating", "that", "stabilization", "requires", "additional", "factors", ".", "To", "clarify", "the", "stabilization", "of", "p53", "mutants", "in", "tumours", ",", "we", "analysed", "factors", "that", "affect", "their", "folding", "and", "degradation", ".", "Although", "all", "missense", "mutants", "that", "we", "studied", "are", "more", "stable", "than", "wild", "-", "type", "p53", ",", "the", "levels", "correlate", "with", "individual", "structural", "characteristics", ",", "which", "may", "be", "reflected", "in", "different", "gain", "-", "of", "-", "function", "properties", ".", "In", "the", "absence", "of", "Hsp90", "activity", ",", "the", "less", "stable", "unfolded", "p53", "mutants", "preferentially", "associate", "in", "a", "complex", "with", "Hsp70", "and", "CHIP", "(", "carboxy", "terminus", "of", "Hsp70-interacting", "protein", ")", ",", "and", "we", "show", "that", "CHIP", "is", "responsible", "for", "ubiquitination", "and", "degradation", "of", "these", "mutants", ".", "The", "demonstration", "of", "a", "complex", "interplay", "between", "Hsp90", ",", "Hsp70", "and", "CHIP", "that", "regulate", "the", "stability", "of", "different", "p53", "mutant", "proteins", "improves", "our", "understanding", "of", "the", "pro", "-", "tumorigenic", "effects", "of", "increased", "Hsp90", "activity", "during", "multi", "-", "stage", "carcinogenesis", ".", "Understanding", "the", "roles", "of", "Hsp90", ",", "Hsp70", "and", "CHIP", "in", "cancers", "may", "also", "provide", "an", "important", "avenue", "through", "which", "to", "target", "p53", "to", "enhance", "treatment", "of", "human", "cancers", ".", "\n" ]
[ "Protein" ]
p53, p53, p53, p53, ubiquitin, MDM2, p53, p53, p53, p53, CHIP, carboxy terminus of Hsp70-interacting protein, CHIP, CHIP, p53, CHIP, p53
297_task2
Sentence: Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chaperone-dependent stabilization and degradation of p53 mutants. p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors. To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural characteristics, which may be reflected in different gain-of-function properties. In the absence of Hsp90 activity, the less stable unfolded p53 mutants preferentially associate in a complex with Hsp70 and CHIP (carboxy terminus of Hsp70-interacting protein), and we show that CHIP is responsible for ubiquitination and degradation of these mutants. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. Understanding the roles of Hsp90, Hsp70 and CHIP in cancers may also provide an important avenue through which to target p53 to enhance treatment of human cancers.
[ "Chaperone", "-", "dependent", "stabilization", "and", "degradation", "of", "p53", "mutants", ".", "\n", "p53", "missense", "mutant", "proteins", "commonly", "show", "increased", "stability", "compared", "to", "wild", "-", "type", "p53", ",", "which", "is", "thought", "to", "depend", "largely", "on", "the", "inability", "of", "mutant", "p53", "to", "induce", "the", "ubiquitin", "ligase", "MDM2", ".", "However", ",", "recent", "work", "using", "mouse", "models", "has", "shown", "that", "the", "accumulation", "of", "mutant", "p53", "occurs", "only", "in", "tumour", "cells", ",", "indicating", "that", "stabilization", "requires", "additional", "factors", ".", "To", "clarify", "the", "stabilization", "of", "p53", "mutants", "in", "tumours", ",", "we", "analysed", "factors", "that", "affect", "their", "folding", "and", "degradation", ".", "Although", "all", "missense", "mutants", "that", "we", "studied", "are", "more", "stable", "than", "wild", "-", "type", "p53", ",", "the", "levels", "correlate", "with", "individual", "structural", "characteristics", ",", "which", "may", "be", "reflected", "in", "different", "gain", "-", "of", "-", "function", "properties", ".", "In", "the", "absence", "of", "Hsp90", "activity", ",", "the", "less", "stable", "unfolded", "p53", "mutants", "preferentially", "associate", "in", "a", "complex", "with", "Hsp70", "and", "CHIP", "(", "carboxy", "terminus", "of", "Hsp70-interacting", "protein", ")", ",", "and", "we", "show", "that", "CHIP", "is", "responsible", "for", "ubiquitination", "and", "degradation", "of", "these", "mutants", ".", "The", "demonstration", "of", "a", "complex", "interplay", "between", "Hsp90", ",", "Hsp70", "and", "CHIP", "that", "regulate", "the", "stability", "of", "different", "p53", "mutant", "proteins", "improves", "our", "understanding", "of", "the", "pro", "-", "tumorigenic", "effects", "of", "increased", "Hsp90", "activity", "during", "multi", "-", "stage", "carcinogenesis", ".", "Understanding", "the", "roles", "of", "Hsp90", ",", "Hsp70", "and", "CHIP", "in", "cancers", "may", "also", "provide", "an", "important", "avenue", "through", "which", "to", "target", "p53", "to", "enhance", "treatment", "of", "human", "cancers", ".", "\n" ]
[ "Protein" ]
Negative regulation is an other_name, human immunodeficiency virus type 1 expression is an other_name, 65-kDa is a protein_subunit, 50-kDa NF - kappa B dimer is a protein_complex
91510_task0
Sentence: Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_complex, protein_subunit, other_name
[ "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_subunit", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]
Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
[ "Negative", "regulation", "of", "human", "immunodeficiency", "virus", "type", "1", "expression", "in", "monocytes", ":", "role", "of", "the", "65-kDa", "plus", "50-kDa", "NF", "-", "kappa", "B", "dimer", "." ]
[ "other_name", "protein_complex", "virus", "protein_family_or_group", "other_organic_compound", "DNA_domain_or_region", "protein_molecule", "lipid", "cell_component", "cell_line", "RNA_family_or_group", "cell_type", "protein_subunit" ]
Negative regulation is an other_name, human immunodeficiency virus type 1 expression is an other_name, 65-kDa is a protein_subunit, 50-kDa NF - kappa B dimer is a protein_complex
91510_task1
Sentence: Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer. Instructions: please typing these entity words according to sentence: Negative regulation, human immunodeficiency virus type 1 expression, 65-kDa, 50-kDa NF - kappa B dimer Options: protein_complex, protein_subunit, other_name
[ "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_subunit", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]
Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
[ "Negative", "regulation", "of", "human", "immunodeficiency", "virus", "type", "1", "expression", "in", "monocytes", ":", "role", "of", "the", "65-kDa", "plus", "50-kDa", "NF", "-", "kappa", "B", "dimer", "." ]
[ "other_name", "protein_complex", "virus", "protein_family_or_group", "other_organic_compound", "DNA_domain_or_region", "protein_molecule", "lipid", "cell_component", "cell_line", "RNA_family_or_group", "cell_type", "protein_subunit" ]
Negative regulation, human immunodeficiency virus type 1 expression, 65-kDa, 50-kDa NF - kappa B dimer
91510_task2
Sentence: Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer. Instructions: please extract entity words from the input sentence
[ "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_subunit", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]
Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
[ "Negative", "regulation", "of", "human", "immunodeficiency", "virus", "type", "1", "expression", "in", "monocytes", ":", "role", "of", "the", "65-kDa", "plus", "50-kDa", "NF", "-", "kappa", "B", "dimer", "." ]
[ "other_name", "protein_complex", "virus", "protein_family_or_group", "other_organic_compound", "DNA_domain_or_region", "protein_molecule", "lipid", "cell_component", "cell_line", "RNA_family_or_group", "cell_type", "protein_subunit" ]
publishing is an umlsterm, peer reviewed is an umlsterm, journals is an umlsterm, Rejection is an umlsterm, aim is an umlsterm, paper is an umlsterm, journal is an umlsterm, papers is an umlsterm, Abstract is an umlsterm, Methods is an umlsterm, suggestions is an umlsterm, review is an umlsterm, manuscript is an umlsterm, journal is an umlsterm, paper is an umlsterm
DerUnfallchirurg.91020377.eng.abstr_task0
Sentence: Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O" ]
Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated .
[ "Nowadays", "scientific", "publishing", "in", "peer", "reviewed", "international", "accepted", "journals", "is", "not", "easy", ".", "Rejection", "rates", "up", "to", "75", "%", "occur", ".", "The", "aim", "of", "this", "paper", "is", "to", "provide", "guidance", "in", "the", "preparation", "of", "journal", "papers", "for", "the", "unexperienced", "scientific", "writer", ".", "The", "traditional", "paragraphs", "Abstract", ",", "Introduction", ",", "Material", "and", "Methods", ",", "Results", ",", "and", "Discussion", "are", "described", "with", "respect", "to", "its", "contents", "and", "basic", "message", "and", "how", "these", "sections", "are", "designed", "to", "build", "a", "logical", "flow", ".", "Approved", "suggestions", "for", "the", "structural", "outline", "of", "each", "paragraph", "are", "made", ".", "The", "significance", "of", "reference", "list", ",", "figures", ",", "and", "tables", "is", "also", "explained", ".", "The", "review", "of", "a", "manuscript", "is", "discussed", "and", "the", "criterias", "for", "acceptance", "of", "a", "journal", "paper", "are", "indicated", "." ]
[ "umlsterm" ]
publishing is an umlsterm, peer reviewed is an umlsterm, journals is an umlsterm, Rejection is an umlsterm, aim is an umlsterm, paper is an umlsterm, journal is an umlsterm, papers is an umlsterm, Abstract is an umlsterm, Methods is an umlsterm, suggestions is an umlsterm, review is an umlsterm, manuscript is an umlsterm, journal is an umlsterm, paper is an umlsterm
DerUnfallchirurg.91020377.eng.abstr_task1
Sentence: Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated . Instructions: please typing these entity words according to sentence: publishing, peer reviewed, journals, Rejection, aim, paper, journal, papers, Abstract, Methods, suggestions, review, manuscript, journal, paper Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O" ]
Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated .
[ "Nowadays", "scientific", "publishing", "in", "peer", "reviewed", "international", "accepted", "journals", "is", "not", "easy", ".", "Rejection", "rates", "up", "to", "75", "%", "occur", ".", "The", "aim", "of", "this", "paper", "is", "to", "provide", "guidance", "in", "the", "preparation", "of", "journal", "papers", "for", "the", "unexperienced", "scientific", "writer", ".", "The", "traditional", "paragraphs", "Abstract", ",", "Introduction", ",", "Material", "and", "Methods", ",", "Results", ",", "and", "Discussion", "are", "described", "with", "respect", "to", "its", "contents", "and", "basic", "message", "and", "how", "these", "sections", "are", "designed", "to", "build", "a", "logical", "flow", ".", "Approved", "suggestions", "for", "the", "structural", "outline", "of", "each", "paragraph", "are", "made", ".", "The", "significance", "of", "reference", "list", ",", "figures", ",", "and", "tables", "is", "also", "explained", ".", "The", "review", "of", "a", "manuscript", "is", "discussed", "and", "the", "criterias", "for", "acceptance", "of", "a", "journal", "paper", "are", "indicated", "." ]
[ "umlsterm" ]
publishing, peer reviewed, journals, Rejection, aim, paper, journal, papers, Abstract, Methods, suggestions, review, manuscript, journal, paper
DerUnfallchirurg.91020377.eng.abstr_task2
Sentence: Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O" ]
Nowadays scientific publishing in peer reviewed international accepted journals is not easy . Rejection rates up to 75 % occur . The aim of this paper is to provide guidance in the preparation of journal papers for the unexperienced scientific writer . The traditional paragraphs Abstract , Introduction , Material and Methods , Results , and Discussion are described with respect to its contents and basic message and how these sections are designed to build a logical flow . Approved suggestions for the structural outline of each paragraph are made . The significance of reference list , figures , and tables is also explained . The review of a manuscript is discussed and the criterias for acceptance of a journal paper are indicated .
[ "Nowadays", "scientific", "publishing", "in", "peer", "reviewed", "international", "accepted", "journals", "is", "not", "easy", ".", "Rejection", "rates", "up", "to", "75", "%", "occur", ".", "The", "aim", "of", "this", "paper", "is", "to", "provide", "guidance", "in", "the", "preparation", "of", "journal", "papers", "for", "the", "unexperienced", "scientific", "writer", ".", "The", "traditional", "paragraphs", "Abstract", ",", "Introduction", ",", "Material", "and", "Methods", ",", "Results", ",", "and", "Discussion", "are", "described", "with", "respect", "to", "its", "contents", "and", "basic", "message", "and", "how", "these", "sections", "are", "designed", "to", "build", "a", "logical", "flow", ".", "Approved", "suggestions", "for", "the", "structural", "outline", "of", "each", "paragraph", "are", "made", ".", "The", "significance", "of", "reference", "list", ",", "figures", ",", "and", "tables", "is", "also", "explained", ".", "The", "review", "of", "a", "manuscript", "is", "discussed", "and", "the", "criterias", "for", "acceptance", "of", "a", "journal", "paper", "are", "indicated", "." ]
[ "umlsterm" ]
Arbeit is an umlsterm, Beurteilung is an umlsterm, Vorhofflattern is an umlsterm, Vorhofflattern is an umlsterm, Verzoegerung is an umlsterm, Arrhythmien is an umlsterm, Patienten is an umlsterm, Arbeit is an umlsterm, Beurteilung is an umlsterm, Vorhofarrhythmien is an umlsterm, selbst is an umlsterm, Analyse is an umlsterm
Herzschrittmachertherapie.9010s032.ger.abstr_task0
Sentence: Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein .
[ "Diese", "Arbeit", "stellt", "einen", "Algorithmus", "zum", "automatischen", "Mode", "-", "Switch", "(", "MS", ")", "vom", "atrial", "triggernden", "in", "den", "nichttriggernden", "Betrieb", "vor", ",", "der", "auf", "einem", "\"", "4", "aus", "7", "\"", "-Konzept", "basiert", ":", "Wenn", "4", "von", "7", "atrialen", "Intervallen", "unterhalb", "eines", "Grenzwertes", "wahrgenommen", "werden", ",", "erfolgt", "MS", ".", "Die", "technische", "Realisation", "in", "Medtronic", "Kappa", "700", "Zweikammer", "-", "Schrittmachern", "wird", "erlaeutert", "zusammen", "mit", "einer", "Beurteilung", "der", "Vorteile", "und", "moeglichen", "Probleme", ":", "Der", "\"", "4", "aus", "7", "\"", "-Algorithmus", "bietet", "einen", "schnellen", "MS", ";", "durch", "den", "Zusatz", "einer", "Flatterwellensuche", "\"", "innerhalb", "der", "Ausblendzeit", "\"", "wird", "die", "Detektion", "von", "Vorhofflattern", "bei", "freier", "programmierbaren", "AV", "-", "Zeiten", "vereinfacht", ".", "Mit", "der", "erhoehten", "MS", "-", "Geschwindigkeit", "und", "Empfindlichkeit", "gegenueber", "Vorhofflattern", "steigt", "jedoch", "auch", "die", "Neigung", ",", "schon", "bei", "kurzen", "atrialen", "Salven", "oder", "gehaeuften", "atrialen", "Extrasystolen", "in", "den", "nichttriggernden", "Betrieb", "umzuschalten", ".", "Zur", "Optimierung", "der", "MS", "-", "Funktion", "sollte", "daher", "die", "Programmierung", "des", "Schrittmachers", "(", "z.", "B.", "Aktivierung", "einer", "Verzoegerung", "vor", "MS", ")", "individuell", "unter", "Beruecksichtigung", "des", "Eigenrhythmus", "und", "der", "atrialen", "Arrhythmien", "des", "Patienten", "erfolgen", ";", "auch", "die", "moeglichen", "Interaktionen", "zwischen", "den", "verschiedenen", "programmierbaren", "Parametern", "sollten", "beruecksichtigt", "werden", ".", "Einige", "Richtlinien", "hierzu", "werden", "in", "der", "Arbeit", "vorgestellt", ".", "Schliesslich", "erscheint", "die", "Ausnutzung", "der", "erweiterten", "diagnostischen", "Speichermoeglichkeiten", "des", "Schrittmachers", "im", "Nachkontrollzeitraum", "von", "entscheidender", "Bedeutung", "zur", "Beurteilung", "der", "Schrittmacherfunktion", ",", "wie", "auch", "der", "Haeufigkeit", "des", "Auftretens", "von", "Vorhofarrhythmien", "und", "(", "soweit", "moeglich", ")", "fuer", "die", "Kontrolle", "der", "Zuverlaesslichkeit", "der", "gespeicherten", "Daten", "selbst", "durch", "Analyse", "der", "gespeicherten", "intrakardialen", "Elektrogramme", "zu", "sein", "." ]
[ "umlsterm" ]
Arbeit is an umlsterm, Beurteilung is an umlsterm, Vorhofflattern is an umlsterm, Vorhofflattern is an umlsterm, Verzoegerung is an umlsterm, Arrhythmien is an umlsterm, Patienten is an umlsterm, Arbeit is an umlsterm, Beurteilung is an umlsterm, Vorhofarrhythmien is an umlsterm, selbst is an umlsterm, Analyse is an umlsterm
Herzschrittmachertherapie.9010s032.ger.abstr_task1
Sentence: Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein . Instructions: please typing these entity words according to sentence: Arbeit, Beurteilung, Vorhofflattern, Vorhofflattern, Verzoegerung, Arrhythmien, Patienten, Arbeit, Beurteilung, Vorhofarrhythmien, selbst, Analyse Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein .
[ "Diese", "Arbeit", "stellt", "einen", "Algorithmus", "zum", "automatischen", "Mode", "-", "Switch", "(", "MS", ")", "vom", "atrial", "triggernden", "in", "den", "nichttriggernden", "Betrieb", "vor", ",", "der", "auf", "einem", "\"", "4", "aus", "7", "\"", "-Konzept", "basiert", ":", "Wenn", "4", "von", "7", "atrialen", "Intervallen", "unterhalb", "eines", "Grenzwertes", "wahrgenommen", "werden", ",", "erfolgt", "MS", ".", "Die", "technische", "Realisation", "in", "Medtronic", "Kappa", "700", "Zweikammer", "-", "Schrittmachern", "wird", "erlaeutert", "zusammen", "mit", "einer", "Beurteilung", "der", "Vorteile", "und", "moeglichen", "Probleme", ":", "Der", "\"", "4", "aus", "7", "\"", "-Algorithmus", "bietet", "einen", "schnellen", "MS", ";", "durch", "den", "Zusatz", "einer", "Flatterwellensuche", "\"", "innerhalb", "der", "Ausblendzeit", "\"", "wird", "die", "Detektion", "von", "Vorhofflattern", "bei", "freier", "programmierbaren", "AV", "-", "Zeiten", "vereinfacht", ".", "Mit", "der", "erhoehten", "MS", "-", "Geschwindigkeit", "und", "Empfindlichkeit", "gegenueber", "Vorhofflattern", "steigt", "jedoch", "auch", "die", "Neigung", ",", "schon", "bei", "kurzen", "atrialen", "Salven", "oder", "gehaeuften", "atrialen", "Extrasystolen", "in", "den", "nichttriggernden", "Betrieb", "umzuschalten", ".", "Zur", "Optimierung", "der", "MS", "-", "Funktion", "sollte", "daher", "die", "Programmierung", "des", "Schrittmachers", "(", "z.", "B.", "Aktivierung", "einer", "Verzoegerung", "vor", "MS", ")", "individuell", "unter", "Beruecksichtigung", "des", "Eigenrhythmus", "und", "der", "atrialen", "Arrhythmien", "des", "Patienten", "erfolgen", ";", "auch", "die", "moeglichen", "Interaktionen", "zwischen", "den", "verschiedenen", "programmierbaren", "Parametern", "sollten", "beruecksichtigt", "werden", ".", "Einige", "Richtlinien", "hierzu", "werden", "in", "der", "Arbeit", "vorgestellt", ".", "Schliesslich", "erscheint", "die", "Ausnutzung", "der", "erweiterten", "diagnostischen", "Speichermoeglichkeiten", "des", "Schrittmachers", "im", "Nachkontrollzeitraum", "von", "entscheidender", "Bedeutung", "zur", "Beurteilung", "der", "Schrittmacherfunktion", ",", "wie", "auch", "der", "Haeufigkeit", "des", "Auftretens", "von", "Vorhofarrhythmien", "und", "(", "soweit", "moeglich", ")", "fuer", "die", "Kontrolle", "der", "Zuverlaesslichkeit", "der", "gespeicherten", "Daten", "selbst", "durch", "Analyse", "der", "gespeicherten", "intrakardialen", "Elektrogramme", "zu", "sein", "." ]
[ "umlsterm" ]
Arbeit, Beurteilung, Vorhofflattern, Vorhofflattern, Verzoegerung, Arrhythmien, Patienten, Arbeit, Beurteilung, Vorhofarrhythmien, selbst, Analyse
Herzschrittmachertherapie.9010s032.ger.abstr_task2
Sentence: Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Diese Arbeit stellt einen Algorithmus zum automatischen Mode-Switch ( MS ) vom atrial triggernden in den nichttriggernden Betrieb vor , der auf einem " 4 aus 7 " -Konzept basiert : Wenn 4 von 7 atrialen Intervallen unterhalb eines Grenzwertes wahrgenommen werden , erfolgt MS . Die technische Realisation in Medtronic Kappa 700 Zweikammer-Schrittmachern wird erlaeutert zusammen mit einer Beurteilung der Vorteile und moeglichen Probleme : Der " 4 aus 7 " -Algorithmus bietet einen schnellen MS ; durch den Zusatz einer Flatterwellensuche " innerhalb der Ausblendzeit " wird die Detektion von Vorhofflattern bei freier programmierbaren AV-Zeiten vereinfacht . Mit der erhoehten MS-Geschwindigkeit und Empfindlichkeit gegenueber Vorhofflattern steigt jedoch auch die Neigung , schon bei kurzen atrialen Salven oder gehaeuften atrialen Extrasystolen in den nichttriggernden Betrieb umzuschalten . Zur Optimierung der MS-Funktion sollte daher die Programmierung des Schrittmachers ( z.B. Aktivierung einer Verzoegerung vor MS ) individuell unter Beruecksichtigung des Eigenrhythmus und der atrialen Arrhythmien des Patienten erfolgen ; auch die moeglichen Interaktionen zwischen den verschiedenen programmierbaren Parametern sollten beruecksichtigt werden . Einige Richtlinien hierzu werden in der Arbeit vorgestellt . Schliesslich erscheint die Ausnutzung der erweiterten diagnostischen Speichermoeglichkeiten des Schrittmachers im Nachkontrollzeitraum von entscheidender Bedeutung zur Beurteilung der Schrittmacherfunktion , wie auch der Haeufigkeit des Auftretens von Vorhofarrhythmien und ( soweit moeglich ) fuer die Kontrolle der Zuverlaesslichkeit der gespeicherten Daten selbst durch Analyse der gespeicherten intrakardialen Elektrogramme zu sein .
[ "Diese", "Arbeit", "stellt", "einen", "Algorithmus", "zum", "automatischen", "Mode", "-", "Switch", "(", "MS", ")", "vom", "atrial", "triggernden", "in", "den", "nichttriggernden", "Betrieb", "vor", ",", "der", "auf", "einem", "\"", "4", "aus", "7", "\"", "-Konzept", "basiert", ":", "Wenn", "4", "von", "7", "atrialen", "Intervallen", "unterhalb", "eines", "Grenzwertes", "wahrgenommen", "werden", ",", "erfolgt", "MS", ".", "Die", "technische", "Realisation", "in", "Medtronic", "Kappa", "700", "Zweikammer", "-", "Schrittmachern", "wird", "erlaeutert", "zusammen", "mit", "einer", "Beurteilung", "der", "Vorteile", "und", "moeglichen", "Probleme", ":", "Der", "\"", "4", "aus", "7", "\"", "-Algorithmus", "bietet", "einen", "schnellen", "MS", ";", "durch", "den", "Zusatz", "einer", "Flatterwellensuche", "\"", "innerhalb", "der", "Ausblendzeit", "\"", "wird", "die", "Detektion", "von", "Vorhofflattern", "bei", "freier", "programmierbaren", "AV", "-", "Zeiten", "vereinfacht", ".", "Mit", "der", "erhoehten", "MS", "-", "Geschwindigkeit", "und", "Empfindlichkeit", "gegenueber", "Vorhofflattern", "steigt", "jedoch", "auch", "die", "Neigung", ",", "schon", "bei", "kurzen", "atrialen", "Salven", "oder", "gehaeuften", "atrialen", "Extrasystolen", "in", "den", "nichttriggernden", "Betrieb", "umzuschalten", ".", "Zur", "Optimierung", "der", "MS", "-", "Funktion", "sollte", "daher", "die", "Programmierung", "des", "Schrittmachers", "(", "z.", "B.", "Aktivierung", "einer", "Verzoegerung", "vor", "MS", ")", "individuell", "unter", "Beruecksichtigung", "des", "Eigenrhythmus", "und", "der", "atrialen", "Arrhythmien", "des", "Patienten", "erfolgen", ";", "auch", "die", "moeglichen", "Interaktionen", "zwischen", "den", "verschiedenen", "programmierbaren", "Parametern", "sollten", "beruecksichtigt", "werden", ".", "Einige", "Richtlinien", "hierzu", "werden", "in", "der", "Arbeit", "vorgestellt", ".", "Schliesslich", "erscheint", "die", "Ausnutzung", "der", "erweiterten", "diagnostischen", "Speichermoeglichkeiten", "des", "Schrittmachers", "im", "Nachkontrollzeitraum", "von", "entscheidender", "Bedeutung", "zur", "Beurteilung", "der", "Schrittmacherfunktion", ",", "wie", "auch", "der", "Haeufigkeit", "des", "Auftretens", "von", "Vorhofarrhythmien", "und", "(", "soweit", "moeglich", ")", "fuer", "die", "Kontrolle", "der", "Zuverlaesslichkeit", "der", "gespeicherten", "Daten", "selbst", "durch", "Analyse", "der", "gespeicherten", "intrakardialen", "Elektrogramme", "zu", "sein", "." ]
[ "umlsterm" ]
Analyse is an umlsterm, Risikofaktoren is an umlsterm, Medizin is an umlsterm, Fruehgeborener is an umlsterm, Zeit is an umlsterm, Methoden is an umlsterm, Lebenstags is an umlsterm, Sauerstoffbedarf is an umlsterm, Lebenstag is an umlsterm, Kinder is an umlsterm, Geburtsgewicht is an umlsterm, Geburtsgewicht is an umlsterm, Risikofaktoren is an umlsterm, Regressionsanalyse is an umlsterm, Kindern is an umlsterm, Kinder is an umlsterm, Risikofaktoren is an umlsterm, Regressionsanalyse is an umlsterm, Gestationsalter is an umlsterm, Geburtsgewicht is an umlsterm, Geburt is an umlsterm, Sauerstoffbedarf is an umlsterm, Gewichtsabnahme is an umlsterm, Lebenswoche is an umlsterm
MonatsschriftKinderheilkunde.61440895.ger.abstr_task0
Sentence: Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden .
[ "Hintergrund", ":", "Zur", "Analyse", "von", "Haeufigkeit", "und", "Risikofaktoren", "der", "bronchopulmonalen", "Dysplasie", "(", "BPD", ")", "auf", "dem", "Hintergrund", "der", "sich", "aendernden", "Bedingungen", "der", "perinatalen", "Medizin", "untersuchten", "wir", "retrospektiv", "die", "Verlaeufe", "Fruehgeborener", ",", "die", "in", "der", "Zeit", "von", "Januar", "1985-Dezember", "1992", "an", "unserer", "Klinik", "betreut", "wurden", ".", "Material", "und", "Methoden", ":", "Waehrend", "des", "1", ".", "Lebenstags", "beatmungsbeduerftige", "Fruehgeborene", "eines", "Geburtsgewichts", "von", "1751", "g", "wurden", "in", "die", "retrospektive", "Studie", "einbezogen", ".", "Die", "BPD", "wurde", "definiert", "als", "Beatmungsnotwendigkeit", "bzw", ".", "Sauerstoffbedarf", "von", ">", "30", "%", "am", "28", ".", "Lebenstag", ".", "Kinder", "mit", "BPD", "wurden", "mit", "einer", "Kontrollgruppe", "(", "Geburtsgewicht", "1751", "g", ")", "verglichen", ",", "wobei", "die", "Auswahl", "nach", "Geburtsjahrgaengen", "und", "Geburtsgewicht", "erfolgte", ".", "Die", "Risikofaktoren", "wurden", "mittels", "logistischer", "Regressionsanalyse", "berechnet", ".", "Ergebnisse", ":", "Von", "insgesamt", "274", "Kindern", "wurde", "bei", "76", "(", "28", "%", ")", "eine", "BPD", "diagnostiziert", ",", "150", "ueberlebten", "ohne", "BPD", ",", "waehrend", "48", "Kinder", "verstarben", ".", "Risikofaktoren", "fuer", "die", "BPD", "stellten", "bei", "einer", "signifikant", "steigenden", "Ueberlebensrate", "und", "sinkenden", "BPD", "-", "Inzidenz", "in", "der", "logistischen", "Regressionsanalyse", "ein", "niedriges", "Gestationsalter", "sowie", "Geburtsgewicht", ",", "vaginale", "Geburt", ",", "hoher", "Sauerstoffbedarf", ",", "geringe", "Gewichtsabnahme", "waehrend", "der", "1", ".", "Lebenswoche", "und", "fehlende", "Surfactanttherapie", "dar", ".", "Schlussfolgerung", ":", "Wir", "fanden", "eine", "verbesserte", "Ueberlebensrate", "beatmungsbeduerftiger", "Fruehgeborener", "bei", "Reduktion", "der", "BPD", "-", "Haeufigkeit", "im", "Untersuchungszeitraum", ".", "Die", "Kenntnis", "der", "BPD", "-", "Risikofaktoren", "sollte", "in", "praeventive", "Konzepte", "umgesetzt", "werden", "." ]
[ "umlsterm" ]
Analyse is an umlsterm, Risikofaktoren is an umlsterm, Medizin is an umlsterm, Fruehgeborener is an umlsterm, Zeit is an umlsterm, Methoden is an umlsterm, Lebenstags is an umlsterm, Sauerstoffbedarf is an umlsterm, Lebenstag is an umlsterm, Kinder is an umlsterm, Geburtsgewicht is an umlsterm, Geburtsgewicht is an umlsterm, Risikofaktoren is an umlsterm, Regressionsanalyse is an umlsterm, Kindern is an umlsterm, Kinder is an umlsterm, Risikofaktoren is an umlsterm, Regressionsanalyse is an umlsterm, Gestationsalter is an umlsterm, Geburtsgewicht is an umlsterm, Geburt is an umlsterm, Sauerstoffbedarf is an umlsterm, Gewichtsabnahme is an umlsterm, Lebenswoche is an umlsterm
MonatsschriftKinderheilkunde.61440895.ger.abstr_task1
Sentence: Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden . Instructions: please typing these entity words according to sentence: Analyse, Risikofaktoren, Medizin, Fruehgeborener, Zeit, Methoden, Lebenstags, Sauerstoffbedarf, Lebenstag, Kinder, Geburtsgewicht, Geburtsgewicht, Risikofaktoren, Regressionsanalyse, Kindern, Kinder, Risikofaktoren, Regressionsanalyse, Gestationsalter, Geburtsgewicht, Geburt, Sauerstoffbedarf, Gewichtsabnahme, Lebenswoche Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden .
[ "Hintergrund", ":", "Zur", "Analyse", "von", "Haeufigkeit", "und", "Risikofaktoren", "der", "bronchopulmonalen", "Dysplasie", "(", "BPD", ")", "auf", "dem", "Hintergrund", "der", "sich", "aendernden", "Bedingungen", "der", "perinatalen", "Medizin", "untersuchten", "wir", "retrospektiv", "die", "Verlaeufe", "Fruehgeborener", ",", "die", "in", "der", "Zeit", "von", "Januar", "1985-Dezember", "1992", "an", "unserer", "Klinik", "betreut", "wurden", ".", "Material", "und", "Methoden", ":", "Waehrend", "des", "1", ".", "Lebenstags", "beatmungsbeduerftige", "Fruehgeborene", "eines", "Geburtsgewichts", "von", "1751", "g", "wurden", "in", "die", "retrospektive", "Studie", "einbezogen", ".", "Die", "BPD", "wurde", "definiert", "als", "Beatmungsnotwendigkeit", "bzw", ".", "Sauerstoffbedarf", "von", ">", "30", "%", "am", "28", ".", "Lebenstag", ".", "Kinder", "mit", "BPD", "wurden", "mit", "einer", "Kontrollgruppe", "(", "Geburtsgewicht", "1751", "g", ")", "verglichen", ",", "wobei", "die", "Auswahl", "nach", "Geburtsjahrgaengen", "und", "Geburtsgewicht", "erfolgte", ".", "Die", "Risikofaktoren", "wurden", "mittels", "logistischer", "Regressionsanalyse", "berechnet", ".", "Ergebnisse", ":", "Von", "insgesamt", "274", "Kindern", "wurde", "bei", "76", "(", "28", "%", ")", "eine", "BPD", "diagnostiziert", ",", "150", "ueberlebten", "ohne", "BPD", ",", "waehrend", "48", "Kinder", "verstarben", ".", "Risikofaktoren", "fuer", "die", "BPD", "stellten", "bei", "einer", "signifikant", "steigenden", "Ueberlebensrate", "und", "sinkenden", "BPD", "-", "Inzidenz", "in", "der", "logistischen", "Regressionsanalyse", "ein", "niedriges", "Gestationsalter", "sowie", "Geburtsgewicht", ",", "vaginale", "Geburt", ",", "hoher", "Sauerstoffbedarf", ",", "geringe", "Gewichtsabnahme", "waehrend", "der", "1", ".", "Lebenswoche", "und", "fehlende", "Surfactanttherapie", "dar", ".", "Schlussfolgerung", ":", "Wir", "fanden", "eine", "verbesserte", "Ueberlebensrate", "beatmungsbeduerftiger", "Fruehgeborener", "bei", "Reduktion", "der", "BPD", "-", "Haeufigkeit", "im", "Untersuchungszeitraum", ".", "Die", "Kenntnis", "der", "BPD", "-", "Risikofaktoren", "sollte", "in", "praeventive", "Konzepte", "umgesetzt", "werden", "." ]
[ "umlsterm" ]
Analyse, Risikofaktoren, Medizin, Fruehgeborener, Zeit, Methoden, Lebenstags, Sauerstoffbedarf, Lebenstag, Kinder, Geburtsgewicht, Geburtsgewicht, Risikofaktoren, Regressionsanalyse, Kindern, Kinder, Risikofaktoren, Regressionsanalyse, Gestationsalter, Geburtsgewicht, Geburt, Sauerstoffbedarf, Gewichtsabnahme, Lebenswoche
MonatsschriftKinderheilkunde.61440895.ger.abstr_task2
Sentence: Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hintergrund : Zur Analyse von Haeufigkeit und Risikofaktoren der bronchopulmonalen Dysplasie ( BPD ) auf dem Hintergrund der sich aendernden Bedingungen der perinatalen Medizin untersuchten wir retrospektiv die Verlaeufe Fruehgeborener , die in der Zeit von Januar 1985-Dezember 1992 an unserer Klinik betreut wurden . Material und Methoden : Waehrend des 1. Lebenstags beatmungsbeduerftige Fruehgeborene eines Geburtsgewichts von 1751 g wurden in die retrospektive Studie einbezogen . Die BPD wurde definiert als Beatmungsnotwendigkeit bzw. Sauerstoffbedarf von > 30 % am 28. Lebenstag . Kinder mit BPD wurden mit einer Kontrollgruppe ( Geburtsgewicht 1751 g ) verglichen , wobei die Auswahl nach Geburtsjahrgaengen und Geburtsgewicht erfolgte . Die Risikofaktoren wurden mittels logistischer Regressionsanalyse berechnet . Ergebnisse : Von insgesamt 274 Kindern wurde bei 76 ( 28 % ) eine BPD diagnostiziert , 150 ueberlebten ohne BPD , waehrend 48 Kinder verstarben . Risikofaktoren fuer die BPD stellten bei einer signifikant steigenden Ueberlebensrate und sinkenden BPD-Inzidenz in der logistischen Regressionsanalyse ein niedriges Gestationsalter sowie Geburtsgewicht , vaginale Geburt , hoher Sauerstoffbedarf , geringe Gewichtsabnahme waehrend der 1. Lebenswoche und fehlende Surfactanttherapie dar . Schlussfolgerung : Wir fanden eine verbesserte Ueberlebensrate beatmungsbeduerftiger Fruehgeborener bei Reduktion der BPD-Haeufigkeit im Untersuchungszeitraum . Die Kenntnis der BPD-Risikofaktoren sollte in praeventive Konzepte umgesetzt werden .
[ "Hintergrund", ":", "Zur", "Analyse", "von", "Haeufigkeit", "und", "Risikofaktoren", "der", "bronchopulmonalen", "Dysplasie", "(", "BPD", ")", "auf", "dem", "Hintergrund", "der", "sich", "aendernden", "Bedingungen", "der", "perinatalen", "Medizin", "untersuchten", "wir", "retrospektiv", "die", "Verlaeufe", "Fruehgeborener", ",", "die", "in", "der", "Zeit", "von", "Januar", "1985-Dezember", "1992", "an", "unserer", "Klinik", "betreut", "wurden", ".", "Material", "und", "Methoden", ":", "Waehrend", "des", "1", ".", "Lebenstags", "beatmungsbeduerftige", "Fruehgeborene", "eines", "Geburtsgewichts", "von", "1751", "g", "wurden", "in", "die", "retrospektive", "Studie", "einbezogen", ".", "Die", "BPD", "wurde", "definiert", "als", "Beatmungsnotwendigkeit", "bzw", ".", "Sauerstoffbedarf", "von", ">", "30", "%", "am", "28", ".", "Lebenstag", ".", "Kinder", "mit", "BPD", "wurden", "mit", "einer", "Kontrollgruppe", "(", "Geburtsgewicht", "1751", "g", ")", "verglichen", ",", "wobei", "die", "Auswahl", "nach", "Geburtsjahrgaengen", "und", "Geburtsgewicht", "erfolgte", ".", "Die", "Risikofaktoren", "wurden", "mittels", "logistischer", "Regressionsanalyse", "berechnet", ".", "Ergebnisse", ":", "Von", "insgesamt", "274", "Kindern", "wurde", "bei", "76", "(", "28", "%", ")", "eine", "BPD", "diagnostiziert", ",", "150", "ueberlebten", "ohne", "BPD", ",", "waehrend", "48", "Kinder", "verstarben", ".", "Risikofaktoren", "fuer", "die", "BPD", "stellten", "bei", "einer", "signifikant", "steigenden", "Ueberlebensrate", "und", "sinkenden", "BPD", "-", "Inzidenz", "in", "der", "logistischen", "Regressionsanalyse", "ein", "niedriges", "Gestationsalter", "sowie", "Geburtsgewicht", ",", "vaginale", "Geburt", ",", "hoher", "Sauerstoffbedarf", ",", "geringe", "Gewichtsabnahme", "waehrend", "der", "1", ".", "Lebenswoche", "und", "fehlende", "Surfactanttherapie", "dar", ".", "Schlussfolgerung", ":", "Wir", "fanden", "eine", "verbesserte", "Ueberlebensrate", "beatmungsbeduerftiger", "Fruehgeborener", "bei", "Reduktion", "der", "BPD", "-", "Haeufigkeit", "im", "Untersuchungszeitraum", ".", "Die", "Kenntnis", "der", "BPD", "-", "Risikofaktoren", "sollte", "in", "praeventive", "Konzepte", "umgesetzt", "werden", "." ]
[ "umlsterm" ]
Mutationen is an umlsterm, Tumoren is an umlsterm, Krebserkrankungen is an umlsterm, Tumorpathologie is an umlsterm, Proteins is an umlsterm, Literatur is an umlsterm, Mammakarzinoms is an umlsterm, Karzinoms is an umlsterm, Magenkarzinoms is an umlsterm, Karzinoms is an umlsterm, Plattenepithelkarzinoms is an umlsterm, Haut is an umlsterm, malignen Melanoms is an umlsterm
DerPathologe.60170181.ger.abstr_task0
Sentence: Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O" ]
Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert .
[ "Mutationen", "des", "p53-Tumorsuppressorgens", "lassen", "sich", "in", "etwa", "50", "%", "aller", "menschlichen", "Tumoren", "nachweisen", ".", "Seine", "Bedeutung", "fuer", "die", "Entstehung", "menschlicher", "Krebserkrankungen", "macht", "dieses", "Gen", "zu", "einem", "zentralen", "Interesse", "molekularpathologischer", "Untersuchungen", ",", "die", "die", "Erfassung", "pathogenetischer", "diagnostischer", "und", "prognostischer", "Parameter", ",", "in", "der", "Tumorpathologie", "zum", "Inhalt", "haben", ".", "In", "dieser", "Uebersichtsarbeit", "werden", "wesentliche", "Aspekte", "der", "Funktion", "des", "p53-Tumorsuppressorgens", "und", "des", "von", "ihm", "kodierten", "Proteins", "dargestellt", ".", "Unter", "Beruecksichtigung", "eigener", "Untersuchungen", "und", "der", "Literatur", "werden", "Haeufigkeit", "und", "Spektrum", "somatischer", "p53-Mutationen", "in", "der", "Kanzerogenese", "des", "Mammakarzinoms", ",", "des", "kolorektalen", "Karzinoms", ",", "des", "Magenkarzinoms", ",", "des", "hepatozellulaeren", "Karzinoms", ",", "des", "Plattenepithelkarzinoms", "der", "Haut", "sowie", "des", "malignen", "Melanoms", "diskutiert", "." ]
[ "umlsterm" ]
Mutationen is an umlsterm, Tumoren is an umlsterm, Krebserkrankungen is an umlsterm, Tumorpathologie is an umlsterm, Proteins is an umlsterm, Literatur is an umlsterm, Mammakarzinoms is an umlsterm, Karzinoms is an umlsterm, Magenkarzinoms is an umlsterm, Karzinoms is an umlsterm, Plattenepithelkarzinoms is an umlsterm, Haut is an umlsterm, malignen Melanoms is an umlsterm
DerPathologe.60170181.ger.abstr_task1
Sentence: Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert . Instructions: please typing these entity words according to sentence: Mutationen, Tumoren, Krebserkrankungen, Tumorpathologie, Proteins, Literatur, Mammakarzinoms, Karzinoms, Magenkarzinoms, Karzinoms, Plattenepithelkarzinoms, Haut, malignen Melanoms Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O" ]
Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert .
[ "Mutationen", "des", "p53-Tumorsuppressorgens", "lassen", "sich", "in", "etwa", "50", "%", "aller", "menschlichen", "Tumoren", "nachweisen", ".", "Seine", "Bedeutung", "fuer", "die", "Entstehung", "menschlicher", "Krebserkrankungen", "macht", "dieses", "Gen", "zu", "einem", "zentralen", "Interesse", "molekularpathologischer", "Untersuchungen", ",", "die", "die", "Erfassung", "pathogenetischer", "diagnostischer", "und", "prognostischer", "Parameter", ",", "in", "der", "Tumorpathologie", "zum", "Inhalt", "haben", ".", "In", "dieser", "Uebersichtsarbeit", "werden", "wesentliche", "Aspekte", "der", "Funktion", "des", "p53-Tumorsuppressorgens", "und", "des", "von", "ihm", "kodierten", "Proteins", "dargestellt", ".", "Unter", "Beruecksichtigung", "eigener", "Untersuchungen", "und", "der", "Literatur", "werden", "Haeufigkeit", "und", "Spektrum", "somatischer", "p53-Mutationen", "in", "der", "Kanzerogenese", "des", "Mammakarzinoms", ",", "des", "kolorektalen", "Karzinoms", ",", "des", "Magenkarzinoms", ",", "des", "hepatozellulaeren", "Karzinoms", ",", "des", "Plattenepithelkarzinoms", "der", "Haut", "sowie", "des", "malignen", "Melanoms", "diskutiert", "." ]
[ "umlsterm" ]
Mutationen, Tumoren, Krebserkrankungen, Tumorpathologie, Proteins, Literatur, Mammakarzinoms, Karzinoms, Magenkarzinoms, Karzinoms, Plattenepithelkarzinoms, Haut, malignen Melanoms
DerPathologe.60170181.ger.abstr_task2
Sentence: Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert . Instructions: please extract entity words from the input sentence
[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O" ]
Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert .
[ "Mutationen", "des", "p53-Tumorsuppressorgens", "lassen", "sich", "in", "etwa", "50", "%", "aller", "menschlichen", "Tumoren", "nachweisen", ".", "Seine", "Bedeutung", "fuer", "die", "Entstehung", "menschlicher", "Krebserkrankungen", "macht", "dieses", "Gen", "zu", "einem", "zentralen", "Interesse", "molekularpathologischer", "Untersuchungen", ",", "die", "die", "Erfassung", "pathogenetischer", "diagnostischer", "und", "prognostischer", "Parameter", ",", "in", "der", "Tumorpathologie", "zum", "Inhalt", "haben", ".", "In", "dieser", "Uebersichtsarbeit", "werden", "wesentliche", "Aspekte", "der", "Funktion", "des", "p53-Tumorsuppressorgens", "und", "des", "von", "ihm", "kodierten", "Proteins", "dargestellt", ".", "Unter", "Beruecksichtigung", "eigener", "Untersuchungen", "und", "der", "Literatur", "werden", "Haeufigkeit", "und", "Spektrum", "somatischer", "p53-Mutationen", "in", "der", "Kanzerogenese", "des", "Mammakarzinoms", ",", "des", "kolorektalen", "Karzinoms", ",", "des", "Magenkarzinoms", ",", "des", "hepatozellulaeren", "Karzinoms", ",", "des", "Plattenepithelkarzinoms", "der", "Haut", "sowie", "des", "malignen", "Melanoms", "diskutiert", "." ]
[ "umlsterm" ]
Halomonas is a Microorganism, cheese is a Habitat, 1 M45 is a Microorganism, smear - ripened cheese is a Habitat, manufacturing plant is a Habitat, Providencia heimbachae GR4 is a Microorganism
119_task0
Sentence: These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Microorganism, Habitat
[ "O", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "B-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O" ]
These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4.
[ "These", "data", "suggest", "that", " ", "the", "Halomonas", "strains", "present", "in", "the", "cheese", "sample", "are", "almost", " ", "identical", "to", "the", "reference", "strain", ".", "However", ",", "even", "though", "the", "reference", " ", "strain", "1", "M45", "has", "also", "been", "isolated", "from", "a", "smear", "-", "ripened", "cheese", "of", " ", "the", "same", "protected", "designation", "of", "origin", ",", "it", "originated", "from", "another", " ", "manufacturing", "plant", ".", "More", "than", "fifty", "thousand", "reads", "were", "assigned", "to", "Providencia", "heimbachae", " ", "GR4", "." ]
[ "Microorganism", "Habitat" ]
Halomonas is a Microorganism, cheese is a Habitat, 1 M45 is a Microorganism, smear - ripened cheese is a Habitat, manufacturing plant is a Habitat, Providencia heimbachae GR4 is a Microorganism
119_task1
Sentence: These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4. Instructions: please typing these entity words according to sentence: Halomonas, cheese, 1 M45, smear - ripened cheese, manufacturing plant, Providencia heimbachae GR4 Options: Microorganism, Habitat
[ "O", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "B-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O" ]
These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4.
[ "These", "data", "suggest", "that", " ", "the", "Halomonas", "strains", "present", "in", "the", "cheese", "sample", "are", "almost", " ", "identical", "to", "the", "reference", "strain", ".", "However", ",", "even", "though", "the", "reference", " ", "strain", "1", "M45", "has", "also", "been", "isolated", "from", "a", "smear", "-", "ripened", "cheese", "of", " ", "the", "same", "protected", "designation", "of", "origin", ",", "it", "originated", "from", "another", " ", "manufacturing", "plant", ".", "More", "than", "fifty", "thousand", "reads", "were", "assigned", "to", "Providencia", "heimbachae", " ", "GR4", "." ]
[ "Microorganism", "Habitat" ]
Halomonas, cheese, 1 M45, smear - ripened cheese, manufacturing plant, Providencia heimbachae GR4
119_task2
Sentence: These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "B-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O" ]
These data suggest that the Halomonas strains present in the cheese sample are almost identical to the reference strain. However, even though the reference strain 1 M45 has also been isolated from a smear-ripened cheese of the same protected designation of origin, it originated from another manufacturing plant. More than fifty thousand reads were assigned to Providencia heimbachae GR4.
[ "These", "data", "suggest", "that", " ", "the", "Halomonas", "strains", "present", "in", "the", "cheese", "sample", "are", "almost", " ", "identical", "to", "the", "reference", "strain", ".", "However", ",", "even", "though", "the", "reference", " ", "strain", "1", "M45", "has", "also", "been", "isolated", "from", "a", "smear", "-", "ripened", "cheese", "of", " ", "the", "same", "protected", "designation", "of", "origin", ",", "it", "originated", "from", "another", " ", "manufacturing", "plant", ".", "More", "than", "fifty", "thousand", "reads", "were", "assigned", "to", "Providencia", "heimbachae", " ", "GR4", "." ]
[ "Microorganism", "Habitat" ]
Echokardiographie is an umlsterm, TEE is an umlsterm, Echokardiographie is an umlsterm, Patienten is an umlsterm, TEE - Technik is an umlsterm, Fieber is an umlsterm, Schmerzsyndromen is an umlsterm, Emboliequellen is an umlsterm, Beurteilung is an umlsterm, Kunstklappenfunktionen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, TEE is an umlsterm, Technik is an umlsterm, Patienten is an umlsterm, Lebensbedrohliche is an umlsterm, Komplikationen is an umlsterm, TEE is an umlsterm, Notfallaufnahme is an umlsterm, Operationssaal is an umlsterm, TEE is an umlsterm, Diagnostik is an umlsterm
ZfuerKardiologie.0089s110.ger.abstr_task0
Sentence: Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen .
[ "Die", "transoesophagele", "Echokardiographie", "(", "TEE", ")", "ist", "eine", "ergaenzende", "Untersuchungstechnik", "zur", "konventionellen", "Echokardiographie", "(", "TTE", ")", "bei", "allen", "Patienten", "mit", "unzureichender", "Schallqualitaet", ".", "Darueber", "hinaus", "bestehen", "eine", "Reihe", "von", "Indikationen", ",", "bei", "denen", "sich", "die", "TEE", "-", "Technik", "als", "hilfreich", "bzw", ".", "aussagekraeftiger", "als", "die", "TTE", "erwiesen", "hat", ",", "u.a", ".", "Abklaerung", "von", "Fieber", "unklarer", "Ursache", ",", "akuten", "thorakalen", "Schmerzsyndromen", "und", "kardiogenen", "Emboliequellen", ",", "Beurteilung", "von", "Kunstklappenfunktionen", ",", "Abklaerung", "von", "hypotonen", "und", "hypoxischen", "Patienten", ",", "intraoperative", "Monitoring", "der", "linksventrikulaeren", "Funktion", "und", "Beurteilung", "der", "Korrektur", "komplexer", "Vitien", "oder", "Mitralklappenrekonstruktionen", ".", "TEE", "ist", "eine", "semiinvasive", "Technik", ",", "die", "in", ">", "95", "%", "der", "Patienten", "erfolgreich", "und", "komplikationslos", "durchgefuehrt", "werden", "kann", ".", "Lebensbedrohliche", "Komplikationen", "sind", "mit", "0,1", "%", "selten", ".", "Der", "prinzipielle", "Vorteil", "der", "TEE", "im", "Vergleich", "zu", "anderen", "bildgebenden", "Verfahren", "ist", "die", "bettseitige", ",", "universell", "verfuegbare", "und", "kostenguenstige", "Anwendbarkeit", ",", "sowohl", "in", "der", "Notfallaufnahme", ",", "auf", "der", "Intensivstation", "als", "auch", "im", "Operationssaal", ".", "Darueber", "hinaus", "verbindet", "TEE", "in", "der", "kardialen", "Diagnostik", "einzigartig", "strukturelle", "mit", "funktionellen", "Daten", ".", "Damit", "ist", "die", "TEE", "-", "Tecnik", "bereits", "heute", "geruestet", ",", "neben", "alternativen", "bildgebenden", "Verfahren", "wie", "dem", "NMR", "auch", "zukuenftig", "bestehen", "zu", "koennen", "." ]
[ "umlsterm" ]
Echokardiographie is an umlsterm, TEE is an umlsterm, Echokardiographie is an umlsterm, Patienten is an umlsterm, TEE - Technik is an umlsterm, Fieber is an umlsterm, Schmerzsyndromen is an umlsterm, Emboliequellen is an umlsterm, Beurteilung is an umlsterm, Kunstklappenfunktionen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, TEE is an umlsterm, Technik is an umlsterm, Patienten is an umlsterm, Lebensbedrohliche is an umlsterm, Komplikationen is an umlsterm, TEE is an umlsterm, Notfallaufnahme is an umlsterm, Operationssaal is an umlsterm, TEE is an umlsterm, Diagnostik is an umlsterm
ZfuerKardiologie.0089s110.ger.abstr_task1
Sentence: Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen . Instructions: please typing these entity words according to sentence: Echokardiographie, TEE, Echokardiographie, Patienten, TEE - Technik, Fieber, Schmerzsyndromen, Emboliequellen, Beurteilung, Kunstklappenfunktionen, Patienten, Beurteilung, TEE, Technik, Patienten, Lebensbedrohliche, Komplikationen, TEE, Notfallaufnahme, Operationssaal, TEE, Diagnostik Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen .
[ "Die", "transoesophagele", "Echokardiographie", "(", "TEE", ")", "ist", "eine", "ergaenzende", "Untersuchungstechnik", "zur", "konventionellen", "Echokardiographie", "(", "TTE", ")", "bei", "allen", "Patienten", "mit", "unzureichender", "Schallqualitaet", ".", "Darueber", "hinaus", "bestehen", "eine", "Reihe", "von", "Indikationen", ",", "bei", "denen", "sich", "die", "TEE", "-", "Technik", "als", "hilfreich", "bzw", ".", "aussagekraeftiger", "als", "die", "TTE", "erwiesen", "hat", ",", "u.a", ".", "Abklaerung", "von", "Fieber", "unklarer", "Ursache", ",", "akuten", "thorakalen", "Schmerzsyndromen", "und", "kardiogenen", "Emboliequellen", ",", "Beurteilung", "von", "Kunstklappenfunktionen", ",", "Abklaerung", "von", "hypotonen", "und", "hypoxischen", "Patienten", ",", "intraoperative", "Monitoring", "der", "linksventrikulaeren", "Funktion", "und", "Beurteilung", "der", "Korrektur", "komplexer", "Vitien", "oder", "Mitralklappenrekonstruktionen", ".", "TEE", "ist", "eine", "semiinvasive", "Technik", ",", "die", "in", ">", "95", "%", "der", "Patienten", "erfolgreich", "und", "komplikationslos", "durchgefuehrt", "werden", "kann", ".", "Lebensbedrohliche", "Komplikationen", "sind", "mit", "0,1", "%", "selten", ".", "Der", "prinzipielle", "Vorteil", "der", "TEE", "im", "Vergleich", "zu", "anderen", "bildgebenden", "Verfahren", "ist", "die", "bettseitige", ",", "universell", "verfuegbare", "und", "kostenguenstige", "Anwendbarkeit", ",", "sowohl", "in", "der", "Notfallaufnahme", ",", "auf", "der", "Intensivstation", "als", "auch", "im", "Operationssaal", ".", "Darueber", "hinaus", "verbindet", "TEE", "in", "der", "kardialen", "Diagnostik", "einzigartig", "strukturelle", "mit", "funktionellen", "Daten", ".", "Damit", "ist", "die", "TEE", "-", "Tecnik", "bereits", "heute", "geruestet", ",", "neben", "alternativen", "bildgebenden", "Verfahren", "wie", "dem", "NMR", "auch", "zukuenftig", "bestehen", "zu", "koennen", "." ]
[ "umlsterm" ]
Echokardiographie, TEE, Echokardiographie, Patienten, TEE - Technik, Fieber, Schmerzsyndromen, Emboliequellen, Beurteilung, Kunstklappenfunktionen, Patienten, Beurteilung, TEE, Technik, Patienten, Lebensbedrohliche, Komplikationen, TEE, Notfallaufnahme, Operationssaal, TEE, Diagnostik
ZfuerKardiologie.0089s110.ger.abstr_task2
Sentence: Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die transoesophagele Echokardiographie ( TEE ) ist eine ergaenzende Untersuchungstechnik zur konventionellen Echokardiographie ( TTE ) bei allen Patienten mit unzureichender Schallqualitaet . Darueber hinaus bestehen eine Reihe von Indikationen , bei denen sich die TEE-Technik als hilfreich bzw. aussagekraeftiger als die TTE erwiesen hat , u.a. Abklaerung von Fieber unklarer Ursache , akuten thorakalen Schmerzsyndromen und kardiogenen Emboliequellen , Beurteilung von Kunstklappenfunktionen , Abklaerung von hypotonen und hypoxischen Patienten , intraoperative Monitoring der linksventrikulaeren Funktion und Beurteilung der Korrektur komplexer Vitien oder Mitralklappenrekonstruktionen . TEE ist eine semiinvasive Technik , die in > 95% der Patienten erfolgreich und komplikationslos durchgefuehrt werden kann . Lebensbedrohliche Komplikationen sind mit 0,1% selten . Der prinzipielle Vorteil der TEE im Vergleich zu anderen bildgebenden Verfahren ist die bettseitige , universell verfuegbare und kostenguenstige Anwendbarkeit , sowohl in der Notfallaufnahme , auf der Intensivstation als auch im Operationssaal . Darueber hinaus verbindet TEE in der kardialen Diagnostik einzigartig strukturelle mit funktionellen Daten . Damit ist die TEE-Tecnik bereits heute geruestet , neben alternativen bildgebenden Verfahren wie dem NMR auch zukuenftig bestehen zu koennen .
[ "Die", "transoesophagele", "Echokardiographie", "(", "TEE", ")", "ist", "eine", "ergaenzende", "Untersuchungstechnik", "zur", "konventionellen", "Echokardiographie", "(", "TTE", ")", "bei", "allen", "Patienten", "mit", "unzureichender", "Schallqualitaet", ".", "Darueber", "hinaus", "bestehen", "eine", "Reihe", "von", "Indikationen", ",", "bei", "denen", "sich", "die", "TEE", "-", "Technik", "als", "hilfreich", "bzw", ".", "aussagekraeftiger", "als", "die", "TTE", "erwiesen", "hat", ",", "u.a", ".", "Abklaerung", "von", "Fieber", "unklarer", "Ursache", ",", "akuten", "thorakalen", "Schmerzsyndromen", "und", "kardiogenen", "Emboliequellen", ",", "Beurteilung", "von", "Kunstklappenfunktionen", ",", "Abklaerung", "von", "hypotonen", "und", "hypoxischen", "Patienten", ",", "intraoperative", "Monitoring", "der", "linksventrikulaeren", "Funktion", "und", "Beurteilung", "der", "Korrektur", "komplexer", "Vitien", "oder", "Mitralklappenrekonstruktionen", ".", "TEE", "ist", "eine", "semiinvasive", "Technik", ",", "die", "in", ">", "95", "%", "der", "Patienten", "erfolgreich", "und", "komplikationslos", "durchgefuehrt", "werden", "kann", ".", "Lebensbedrohliche", "Komplikationen", "sind", "mit", "0,1", "%", "selten", ".", "Der", "prinzipielle", "Vorteil", "der", "TEE", "im", "Vergleich", "zu", "anderen", "bildgebenden", "Verfahren", "ist", "die", "bettseitige", ",", "universell", "verfuegbare", "und", "kostenguenstige", "Anwendbarkeit", ",", "sowohl", "in", "der", "Notfallaufnahme", ",", "auf", "der", "Intensivstation", "als", "auch", "im", "Operationssaal", ".", "Darueber", "hinaus", "verbindet", "TEE", "in", "der", "kardialen", "Diagnostik", "einzigartig", "strukturelle", "mit", "funktionellen", "Daten", ".", "Damit", "ist", "die", "TEE", "-", "Tecnik", "bereits", "heute", "geruestet", ",", "neben", "alternativen", "bildgebenden", "Verfahren", "wie", "dem", "NMR", "auch", "zukuenftig", "bestehen", "zu", "koennen", "." ]
[ "umlsterm" ]
Cimetidine is a Intervention_Pharmacological, effective is a Outcome_Other, placebo is a Intervention_Control, acute infectious mononucleosis . is a Participant_Condition
85593_task0
Sentence: Cimetidine is not more effective than placebo in acute infectious mononucleosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Intervention_Control, Participant_Condition
[ "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Control", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]
Cimetidine is not more effective than placebo in acute infectious mononucleosis .
[ "Cimetidine", "is", "not", "more", "effective", "than", "placebo", "in", "acute", "infectious", "mononucleosis", "." ]
[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control" ]
Cimetidine is a Intervention_Pharmacological, effective is a Outcome_Other, placebo is a Intervention_Control, acute infectious mononucleosis . is a Participant_Condition
85593_task1
Sentence: Cimetidine is not more effective than placebo in acute infectious mononucleosis . Instructions: please typing these entity words according to sentence: Cimetidine, effective, placebo, acute infectious mononucleosis . Options: Outcome_Other, Intervention_Pharmacological, Intervention_Control, Participant_Condition
[ "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Control", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]
Cimetidine is not more effective than placebo in acute infectious mononucleosis .
[ "Cimetidine", "is", "not", "more", "effective", "than", "placebo", "in", "acute", "infectious", "mononucleosis", "." ]
[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control" ]
Cimetidine, effective, placebo, acute infectious mononucleosis .
85593_task2
Sentence: Cimetidine is not more effective than placebo in acute infectious mononucleosis . Instructions: please extract entity words from the input sentence
[ "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Control", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]
Cimetidine is not more effective than placebo in acute infectious mononucleosis .
[ "Cimetidine", "is", "not", "more", "effective", "than", "placebo", "in", "acute", "infectious", "mononucleosis", "." ]
[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control" ]
Befragung is an umlsterm, Erwerbsbevoelkerung is an umlsterm, Deutschland is an umlsterm, Belastungen is an umlsterm, weiblichen is an umlsterm, maennlichen is an umlsterm, Belastungen is an umlsterm, Erwerbsbevoelkerung is an umlsterm, Gesundheitsfoerderung is an umlsterm
ZfuerGerontologie+Geriatrie.00330256.ger.abstr_task0
Sentence: Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen .
[ "Es", "werden", "Sonderauswertungen", "einer", "repraesentativen", "Befragung", "der", "Erwerbsbevoelkerung", "in", "Deutschland", "(", "N=34343", ")", "zum", "Thema", "\"", "Belastungen", "und", "Beanspruchungen", "sowie", "arbeitsbedingten", "Erkrankungen", "\"", "bezogen", "auf", "die", "Gruppe", "der", "45-jaehrigen", "und", "aelteren", "weiblichen", "und", "maennlichen", "Beschaeftigten", "des", "Dienstleistungssektors", "(", "N=8310", ")", "vorgestellt", ".", "Es", "zeigt", "sich", "im", "Ergebnis", ",", "dass", "aeltere", "Erwerbstaetige", "in", "diesem", "Beschaeftigungssegment", "keineswegs", "geringen", "Belastungen", "unterliegen", "und", "dass", "diese", "oft", "hoeher", "sind", "als", "in", "der", "Erwerbsbevoelkerung", "insgesamt", ".", "Daher", "kann", "gefolgert", "werden", ",", "dass", "nicht", "zuletzt", "vor", "dem", "Hintergrund", "des", "demografischen", "Wandels", "auch", "im", "Dienstleistungsbereich", "Massnahmen", "fuer", "eine", "umfassende", "Gesundheitsfoerderung", "fuer", "aelter", "werdenden", "und", "aeltere", "Beschaeftigte", "getroffen", "werden", "muessen", "." ]
[ "umlsterm" ]
Befragung is an umlsterm, Erwerbsbevoelkerung is an umlsterm, Deutschland is an umlsterm, Belastungen is an umlsterm, weiblichen is an umlsterm, maennlichen is an umlsterm, Belastungen is an umlsterm, Erwerbsbevoelkerung is an umlsterm, Gesundheitsfoerderung is an umlsterm
ZfuerGerontologie+Geriatrie.00330256.ger.abstr_task1
Sentence: Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen . Instructions: please typing these entity words according to sentence: Befragung, Erwerbsbevoelkerung, Deutschland, Belastungen, weiblichen, maennlichen, Belastungen, Erwerbsbevoelkerung, Gesundheitsfoerderung Options: umlsterm
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen .
[ "Es", "werden", "Sonderauswertungen", "einer", "repraesentativen", "Befragung", "der", "Erwerbsbevoelkerung", "in", "Deutschland", "(", "N=34343", ")", "zum", "Thema", "\"", "Belastungen", "und", "Beanspruchungen", "sowie", "arbeitsbedingten", "Erkrankungen", "\"", "bezogen", "auf", "die", "Gruppe", "der", "45-jaehrigen", "und", "aelteren", "weiblichen", "und", "maennlichen", "Beschaeftigten", "des", "Dienstleistungssektors", "(", "N=8310", ")", "vorgestellt", ".", "Es", "zeigt", "sich", "im", "Ergebnis", ",", "dass", "aeltere", "Erwerbstaetige", "in", "diesem", "Beschaeftigungssegment", "keineswegs", "geringen", "Belastungen", "unterliegen", "und", "dass", "diese", "oft", "hoeher", "sind", "als", "in", "der", "Erwerbsbevoelkerung", "insgesamt", ".", "Daher", "kann", "gefolgert", "werden", ",", "dass", "nicht", "zuletzt", "vor", "dem", "Hintergrund", "des", "demografischen", "Wandels", "auch", "im", "Dienstleistungsbereich", "Massnahmen", "fuer", "eine", "umfassende", "Gesundheitsfoerderung", "fuer", "aelter", "werdenden", "und", "aeltere", "Beschaeftigte", "getroffen", "werden", "muessen", "." ]
[ "umlsterm" ]
Befragung, Erwerbsbevoelkerung, Deutschland, Belastungen, weiblichen, maennlichen, Belastungen, Erwerbsbevoelkerung, Gesundheitsfoerderung
ZfuerGerontologie+Geriatrie.00330256.ger.abstr_task2
Sentence: Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Es werden Sonderauswertungen einer repraesentativen Befragung der Erwerbsbevoelkerung in Deutschland ( N=34343) zum Thema " Belastungen und Beanspruchungen sowie arbeitsbedingten Erkrankungen " bezogen auf die Gruppe der 45-jaehrigen und aelteren weiblichen und maennlichen Beschaeftigten des Dienstleistungssektors ( N=8310) vorgestellt . Es zeigt sich im Ergebnis , dass aeltere Erwerbstaetige in diesem Beschaeftigungssegment keineswegs geringen Belastungen unterliegen und dass diese oft hoeher sind als in der Erwerbsbevoelkerung insgesamt . Daher kann gefolgert werden , dass nicht zuletzt vor dem Hintergrund des demografischen Wandels auch im Dienstleistungsbereich Massnahmen fuer eine umfassende Gesundheitsfoerderung fuer aelter werdenden und aeltere Beschaeftigte getroffen werden muessen .
[ "Es", "werden", "Sonderauswertungen", "einer", "repraesentativen", "Befragung", "der", "Erwerbsbevoelkerung", "in", "Deutschland", "(", "N=34343", ")", "zum", "Thema", "\"", "Belastungen", "und", "Beanspruchungen", "sowie", "arbeitsbedingten", "Erkrankungen", "\"", "bezogen", "auf", "die", "Gruppe", "der", "45-jaehrigen", "und", "aelteren", "weiblichen", "und", "maennlichen", "Beschaeftigten", "des", "Dienstleistungssektors", "(", "N=8310", ")", "vorgestellt", ".", "Es", "zeigt", "sich", "im", "Ergebnis", ",", "dass", "aeltere", "Erwerbstaetige", "in", "diesem", "Beschaeftigungssegment", "keineswegs", "geringen", "Belastungen", "unterliegen", "und", "dass", "diese", "oft", "hoeher", "sind", "als", "in", "der", "Erwerbsbevoelkerung", "insgesamt", ".", "Daher", "kann", "gefolgert", "werden", ",", "dass", "nicht", "zuletzt", "vor", "dem", "Hintergrund", "des", "demografischen", "Wandels", "auch", "im", "Dienstleistungsbereich", "Massnahmen", "fuer", "eine", "umfassende", "Gesundheitsfoerderung", "fuer", "aelter", "werdenden", "und", "aeltere", "Beschaeftigte", "getroffen", "werden", "muessen", "." ]
[ "umlsterm" ]
Stapled mucosectomy is a Intervention_Physical, conventional haemorrhoidectomy is a Intervention_Physical, conventional procedure is a Intervention_Physical, acute thrombosed circumferential prolapsed haemorrhoids is a Participant_Condition, conventional Milligan - Morgan haemorrhoidectomy and stapled mucosectomy is a Intervention_Physical, 35 is a Participant_Sample-size, Operative data is a Outcome_Other, postoperative stay is a Outcome_Other, pain assessment is a Outcome_Pain, persistent symptoms is a Outcome_Pain, discharge is a Outcome_Physical, endoanal ultrasound is a Intervention_Surgical, Thirty is a Participant_Sample-size, in - hospital analgesia is a Outcome_Other, stapled group is a Participant_Sample-size, conventional group is a Intervention_Educational, higher pain scores is a Outcome_Pain, no pain is a Outcome_Pain, persistent symptoms of pain is a Outcome_Pain, bleeding is a Outcome_Physical, median return to work was significantly shorter is a Outcome_Other, internal sphincter damage is a Outcome_Physical, less pain is a Outcome_Pain
13090_task0
Sentence: Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Intervention_Educational, Outcome_Pain, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure .
[ "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferentially", "prolapsed", "piles", ":", "a", "prospective", "randomized", "comparison", "with", "conventional", "haemorrhoidectomy", ".", "OBJECTIVE", "Stapled", "mucosectomy", "has", "been", "developed", "as", "an", "alternative", "to", "conventional", "haemorrhoidectomy", "for", "the", "elective", "treatment", "of", "haemorrhoids", ",", "but", "has", "not", "been", "assessed", "in", "the", "emergency", "setting", ".", "The", "aim", "of", "this", "study", "was", "to", "compare", "this", "technique", "with", "a", "conventional", "procedure", "for", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "PATIENTS", "AND", "METHODS", "A", "prospective", "randomized", "comparison", "of", "conventional", "Milligan", "-", "Morgan", "haemorrhoidectomy", "and", "stapled", "mucosectomy", "was", "carried", "out", "on", "35", "consecutive", "patients", "presenting", "with", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "Operative", "data", ",", "postoperative", "stay", ",", "pain", "assessment", "and", "persistent", "symptoms", "were", "compared", "at", "discharge", "and", "at", "2", "week", "and", "6", "week", "review", ".", "Additionally", "at", "6", "week", "review", "the", "time", "to", "return", "to", "work", "was", "recorded", "and", "an", "endoanal", "ultrasound", "was", "carried", "out", ".", "RESULTS", "Thirty", "patients", "were", "randomized", "and", "followed", "up", "for", "six", "weeks", ".", "Although", "postoperative", "stay", "and", "in", "-", "hospital", "analgesia", "were", "the", "same", ",", "patients", "from", "the", "stapled", "group", "reported", "significantly", "more", "pain", "at", "discharge", ".", "However", ",", "by", "2", "weeks", "the", "conventional", "group", "reported", "significantly", "higher", "pain", "scores", "particularly", "on", "passing", "stool", ".", "By", "this", "stage", "over", "half", "the", "stapled", "group", "patients", "reported", "no", "pain", "at", "all", ".", "More", "patients", "in", "the", "conventional", "group", "complained", "of", "persistent", "symptoms", "of", "pain", ",", "bleeding", "and", "discharge", "at", "2", "week", "and", "6", "week", "review", "with", "20", "%", "requiring", "readmission", "compared", "with", "none", "in", "the", "stapled", "group", ".", "The", "median", "return", "to", "work", "was", "significantly", "shorter", "for", "the", "stapled", "group", "(", "14", "days", "vs", "28", "days", ",", "P", "<", "0.05", ")", ".", "Although", "all", "patients", "claimed", "to", "be", "continent", ",", "two", "patients", "from", "each", "group", "had", "ultrasonic", "evidence", "of", "internal", "sphincter", "damage", ".", "CONCLUSION", "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferential", "piles", "is", "feasible", "and", "may", "result", "in", "less", "pain", ",", "a", "more", "rapid", "resolution", "of", "symptoms", "and", "an", "earlier", "return", "to", "work", "compared", "with", "a", "conventional", "procedure", "." ]
[ "Intervention_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Pain", "Outcome_Physical", "Intervention_Surgical", "Intervention_Educational", "Participant_Sample-size" ]
Stapled mucosectomy is a Intervention_Physical, conventional haemorrhoidectomy is a Intervention_Physical, conventional procedure is a Intervention_Physical, acute thrombosed circumferential prolapsed haemorrhoids is a Participant_Condition, conventional Milligan - Morgan haemorrhoidectomy and stapled mucosectomy is a Intervention_Physical, 35 is a Participant_Sample-size, Operative data is a Outcome_Other, postoperative stay is a Outcome_Other, pain assessment is a Outcome_Pain, persistent symptoms is a Outcome_Pain, discharge is a Outcome_Physical, endoanal ultrasound is a Intervention_Surgical, Thirty is a Participant_Sample-size, in - hospital analgesia is a Outcome_Other, stapled group is a Participant_Sample-size, conventional group is a Intervention_Educational, higher pain scores is a Outcome_Pain, no pain is a Outcome_Pain, persistent symptoms of pain is a Outcome_Pain, bleeding is a Outcome_Physical, median return to work was significantly shorter is a Outcome_Other, internal sphincter damage is a Outcome_Physical, less pain is a Outcome_Pain
13090_task1
Sentence: Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure . Instructions: please typing these entity words according to sentence: Stapled mucosectomy, conventional haemorrhoidectomy, conventional procedure, acute thrombosed circumferential prolapsed haemorrhoids, conventional Milligan - Morgan haemorrhoidectomy and stapled mucosectomy, 35, Operative data, postoperative stay, pain assessment, persistent symptoms, discharge, endoanal ultrasound, Thirty, in - hospital analgesia, stapled group, conventional group, higher pain scores, no pain, persistent symptoms of pain, bleeding, median return to work was significantly shorter, internal sphincter damage, less pain Options: Intervention_Physical, Participant_Condition, Intervention_Educational, Outcome_Pain, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure .
[ "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferentially", "prolapsed", "piles", ":", "a", "prospective", "randomized", "comparison", "with", "conventional", "haemorrhoidectomy", ".", "OBJECTIVE", "Stapled", "mucosectomy", "has", "been", "developed", "as", "an", "alternative", "to", "conventional", "haemorrhoidectomy", "for", "the", "elective", "treatment", "of", "haemorrhoids", ",", "but", "has", "not", "been", "assessed", "in", "the", "emergency", "setting", ".", "The", "aim", "of", "this", "study", "was", "to", "compare", "this", "technique", "with", "a", "conventional", "procedure", "for", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "PATIENTS", "AND", "METHODS", "A", "prospective", "randomized", "comparison", "of", "conventional", "Milligan", "-", "Morgan", "haemorrhoidectomy", "and", "stapled", "mucosectomy", "was", "carried", "out", "on", "35", "consecutive", "patients", "presenting", "with", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "Operative", "data", ",", "postoperative", "stay", ",", "pain", "assessment", "and", "persistent", "symptoms", "were", "compared", "at", "discharge", "and", "at", "2", "week", "and", "6", "week", "review", ".", "Additionally", "at", "6", "week", "review", "the", "time", "to", "return", "to", "work", "was", "recorded", "and", "an", "endoanal", "ultrasound", "was", "carried", "out", ".", "RESULTS", "Thirty", "patients", "were", "randomized", "and", "followed", "up", "for", "six", "weeks", ".", "Although", "postoperative", "stay", "and", "in", "-", "hospital", "analgesia", "were", "the", "same", ",", "patients", "from", "the", "stapled", "group", "reported", "significantly", "more", "pain", "at", "discharge", ".", "However", ",", "by", "2", "weeks", "the", "conventional", "group", "reported", "significantly", "higher", "pain", "scores", "particularly", "on", "passing", "stool", ".", "By", "this", "stage", "over", "half", "the", "stapled", "group", "patients", "reported", "no", "pain", "at", "all", ".", "More", "patients", "in", "the", "conventional", "group", "complained", "of", "persistent", "symptoms", "of", "pain", ",", "bleeding", "and", "discharge", "at", "2", "week", "and", "6", "week", "review", "with", "20", "%", "requiring", "readmission", "compared", "with", "none", "in", "the", "stapled", "group", ".", "The", "median", "return", "to", "work", "was", "significantly", "shorter", "for", "the", "stapled", "group", "(", "14", "days", "vs", "28", "days", ",", "P", "<", "0.05", ")", ".", "Although", "all", "patients", "claimed", "to", "be", "continent", ",", "two", "patients", "from", "each", "group", "had", "ultrasonic", "evidence", "of", "internal", "sphincter", "damage", ".", "CONCLUSION", "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferential", "piles", "is", "feasible", "and", "may", "result", "in", "less", "pain", ",", "a", "more", "rapid", "resolution", "of", "symptoms", "and", "an", "earlier", "return", "to", "work", "compared", "with", "a", "conventional", "procedure", "." ]
[ "Intervention_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Pain", "Outcome_Physical", "Intervention_Surgical", "Intervention_Educational", "Participant_Sample-size" ]
Stapled mucosectomy, conventional haemorrhoidectomy, conventional procedure, acute thrombosed circumferential prolapsed haemorrhoids, conventional Milligan - Morgan haemorrhoidectomy and stapled mucosectomy, 35, Operative data, postoperative stay, pain assessment, persistent symptoms, discharge, endoanal ultrasound, Thirty, in - hospital analgesia, stapled group, conventional group, higher pain scores, no pain, persistent symptoms of pain, bleeding, median return to work was significantly shorter, internal sphincter damage, less pain
13090_task2
Sentence: Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure . Instructions: please extract entity words from the input sentence
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Stapled mucosectomy for acute thrombosed circumferentially prolapsed piles : a prospective randomized comparison with conventional haemorrhoidectomy . OBJECTIVE Stapled mucosectomy has been developed as an alternative to conventional haemorrhoidectomy for the elective treatment of haemorrhoids , but has not been assessed in the emergency setting . The aim of this study was to compare this technique with a conventional procedure for acute thrombosed circumferential prolapsed haemorrhoids . PATIENTS AND METHODS A prospective randomized comparison of conventional Milligan-Morgan haemorrhoidectomy and stapled mucosectomy was carried out on 35 consecutive patients presenting with acute thrombosed circumferential prolapsed haemorrhoids . Operative data , postoperative stay , pain assessment and persistent symptoms were compared at discharge and at 2 week and 6 week review . Additionally at 6 week review the time to return to work was recorded and an endoanal ultrasound was carried out . RESULTS Thirty patients were randomized and followed up for six weeks . Although postoperative stay and in-hospital analgesia were the same , patients from the stapled group reported significantly more pain at discharge . However , by 2 weeks the conventional group reported significantly higher pain scores particularly on passing stool . By this stage over half the stapled group patients reported no pain at all . More patients in the conventional group complained of persistent symptoms of pain , bleeding and discharge at 2 week and 6 week review with 20 % requiring readmission compared with none in the stapled group . The median return to work was significantly shorter for the stapled group ( 14 days vs 28 days , P < 0.05 ) . Although all patients claimed to be continent , two patients from each group had ultrasonic evidence of internal sphincter damage . CONCLUSION Stapled mucosectomy for acute thrombosed circumferential piles is feasible and may result in less pain , a more rapid resolution of symptoms and an earlier return to work compared with a conventional procedure .
[ "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferentially", "prolapsed", "piles", ":", "a", "prospective", "randomized", "comparison", "with", "conventional", "haemorrhoidectomy", ".", "OBJECTIVE", "Stapled", "mucosectomy", "has", "been", "developed", "as", "an", "alternative", "to", "conventional", "haemorrhoidectomy", "for", "the", "elective", "treatment", "of", "haemorrhoids", ",", "but", "has", "not", "been", "assessed", "in", "the", "emergency", "setting", ".", "The", "aim", "of", "this", "study", "was", "to", "compare", "this", "technique", "with", "a", "conventional", "procedure", "for", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "PATIENTS", "AND", "METHODS", "A", "prospective", "randomized", "comparison", "of", "conventional", "Milligan", "-", "Morgan", "haemorrhoidectomy", "and", "stapled", "mucosectomy", "was", "carried", "out", "on", "35", "consecutive", "patients", "presenting", "with", "acute", "thrombosed", "circumferential", "prolapsed", "haemorrhoids", ".", "Operative", "data", ",", "postoperative", "stay", ",", "pain", "assessment", "and", "persistent", "symptoms", "were", "compared", "at", "discharge", "and", "at", "2", "week", "and", "6", "week", "review", ".", "Additionally", "at", "6", "week", "review", "the", "time", "to", "return", "to", "work", "was", "recorded", "and", "an", "endoanal", "ultrasound", "was", "carried", "out", ".", "RESULTS", "Thirty", "patients", "were", "randomized", "and", "followed", "up", "for", "six", "weeks", ".", "Although", "postoperative", "stay", "and", "in", "-", "hospital", "analgesia", "were", "the", "same", ",", "patients", "from", "the", "stapled", "group", "reported", "significantly", "more", "pain", "at", "discharge", ".", "However", ",", "by", "2", "weeks", "the", "conventional", "group", "reported", "significantly", "higher", "pain", "scores", "particularly", "on", "passing", "stool", ".", "By", "this", "stage", "over", "half", "the", "stapled", "group", "patients", "reported", "no", "pain", "at", "all", ".", "More", "patients", "in", "the", "conventional", "group", "complained", "of", "persistent", "symptoms", "of", "pain", ",", "bleeding", "and", "discharge", "at", "2", "week", "and", "6", "week", "review", "with", "20", "%", "requiring", "readmission", "compared", "with", "none", "in", "the", "stapled", "group", ".", "The", "median", "return", "to", "work", "was", "significantly", "shorter", "for", "the", "stapled", "group", "(", "14", "days", "vs", "28", "days", ",", "P", "<", "0.05", ")", ".", "Although", "all", "patients", "claimed", "to", "be", "continent", ",", "two", "patients", "from", "each", "group", "had", "ultrasonic", "evidence", "of", "internal", "sphincter", "damage", ".", "CONCLUSION", "Stapled", "mucosectomy", "for", "acute", "thrombosed", "circumferential", "piles", "is", "feasible", "and", "may", "result", "in", "less", "pain", ",", "a", "more", "rapid", "resolution", "of", "symptoms", "and", "an", "earlier", "return", "to", "work", "compared", "with", "a", "conventional", "procedure", "." ]
[ "Intervention_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Pain", "Outcome_Physical", "Intervention_Surgical", "Intervention_Educational", "Participant_Sample-size" ]
aim is an umlsterm, serial is an umlsterm, follow - up study is an umlsterm, patients is an umlsterm, dissection is an umlsterm, descending thoracic aorta is an umlsterm, transesophageal echocardiography is an umlsterm, dissections is an umlsterm, patients is an umlsterm, patients is an umlsterm, enlargement is an umlsterm, thoracic aorta is an umlsterm, value is an umlsterm, patients is an umlsterm, FL is an umlsterm, period is an umlsterm, thrombosis is an umlsterm, FL is an umlsterm, patients is an umlsterm, thrombosis is an umlsterm, FL is an umlsterm, patients is an umlsterm
ZfuerKardiologie.90880507.eng.abstr_task0
Sentence: The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients .
[ "The", "aim", "of", "this", "serial", "3", "year", "follow", "-", "up", "study", "in", "42", "clinically", "stable", "patients", "with", "chronic", "aortic", "dissection", "was", "to", "assess", "quantitatively", "morphologic", "changes", "of", "the", "descending", "thoracic", "aorta", "(", "AD", ")", "using", "transesophageal", "echocardiography", "(", "TEE", ")", ".", "Communicating", "dissections", "(", "ca", ")", "were", "present", "in", "16/19", "patients", "with", "operated", "type", "I", "and", "in", "11/23", "patients", "with", "type", "III", "AD", "wherase", "12/23", "type", "III", "AD", "according", "to", "De", "Bakey", "were", "non", "-", "communicating", "(", "nc", ")", ".", "Diametral", "enlargement", "of", "the", "desc", ".", "thoracic", "aorta", "was", "4", "mm", "(", "mean", "value", ")", "at", "1", "year", "in", "all", "patients", ",", "5.9", "mm", "in", "type", "I", "ca", ",", "7.2", "mm", "in", "type", "III", "ca", "but", "only", "3.1", "mm", "in", "type", "III", "nc", "at", "3", "years", ".", "The", "ration", "between", "true", "lumen", "and", "false", "lumen", "(", "FL", ")", "changed", "in", "ca", "AD", "from", "1:2", "to", "1:3", "over", "the", "period", "of", "3", "years", "but", "remained", "constant", "at", "1:1", "in", "ncAD", ".", "Progressive", "thrombosis", "of", "the", "false", "lumen", "(", "FL", ")", "occurred", "in", "76", "%", "of", "patients", "but", "complete", "thrombosis", "of", "the", "FL", "occurred", "in", "only", "6", "%", "of", "type", "I", "ca", ",", "18", "%", "type", "III", "ca", "but", "in", "84", "%", "of", "type", "III", "nc", "patients", "." ]
[ "umlsterm" ]
aim is an umlsterm, serial is an umlsterm, follow - up study is an umlsterm, patients is an umlsterm, dissection is an umlsterm, descending thoracic aorta is an umlsterm, transesophageal echocardiography is an umlsterm, dissections is an umlsterm, patients is an umlsterm, patients is an umlsterm, enlargement is an umlsterm, thoracic aorta is an umlsterm, value is an umlsterm, patients is an umlsterm, FL is an umlsterm, period is an umlsterm, thrombosis is an umlsterm, FL is an umlsterm, patients is an umlsterm, thrombosis is an umlsterm, FL is an umlsterm, patients is an umlsterm
ZfuerKardiologie.90880507.eng.abstr_task1
Sentence: The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients . Instructions: please typing these entity words according to sentence: aim, serial, follow - up study, patients, dissection, descending thoracic aorta, transesophageal echocardiography, dissections, patients, patients, enlargement, thoracic aorta, value, patients, FL, period, thrombosis, FL, patients, thrombosis, FL, patients Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients .
[ "The", "aim", "of", "this", "serial", "3", "year", "follow", "-", "up", "study", "in", "42", "clinically", "stable", "patients", "with", "chronic", "aortic", "dissection", "was", "to", "assess", "quantitatively", "morphologic", "changes", "of", "the", "descending", "thoracic", "aorta", "(", "AD", ")", "using", "transesophageal", "echocardiography", "(", "TEE", ")", ".", "Communicating", "dissections", "(", "ca", ")", "were", "present", "in", "16/19", "patients", "with", "operated", "type", "I", "and", "in", "11/23", "patients", "with", "type", "III", "AD", "wherase", "12/23", "type", "III", "AD", "according", "to", "De", "Bakey", "were", "non", "-", "communicating", "(", "nc", ")", ".", "Diametral", "enlargement", "of", "the", "desc", ".", "thoracic", "aorta", "was", "4", "mm", "(", "mean", "value", ")", "at", "1", "year", "in", "all", "patients", ",", "5.9", "mm", "in", "type", "I", "ca", ",", "7.2", "mm", "in", "type", "III", "ca", "but", "only", "3.1", "mm", "in", "type", "III", "nc", "at", "3", "years", ".", "The", "ration", "between", "true", "lumen", "and", "false", "lumen", "(", "FL", ")", "changed", "in", "ca", "AD", "from", "1:2", "to", "1:3", "over", "the", "period", "of", "3", "years", "but", "remained", "constant", "at", "1:1", "in", "ncAD", ".", "Progressive", "thrombosis", "of", "the", "false", "lumen", "(", "FL", ")", "occurred", "in", "76", "%", "of", "patients", "but", "complete", "thrombosis", "of", "the", "FL", "occurred", "in", "only", "6", "%", "of", "type", "I", "ca", ",", "18", "%", "type", "III", "ca", "but", "in", "84", "%", "of", "type", "III", "nc", "patients", "." ]
[ "umlsterm" ]
aim, serial, follow - up study, patients, dissection, descending thoracic aorta, transesophageal echocardiography, dissections, patients, patients, enlargement, thoracic aorta, value, patients, FL, period, thrombosis, FL, patients, thrombosis, FL, patients
ZfuerKardiologie.90880507.eng.abstr_task2
Sentence: The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients .
[ "The", "aim", "of", "this", "serial", "3", "year", "follow", "-", "up", "study", "in", "42", "clinically", "stable", "patients", "with", "chronic", "aortic", "dissection", "was", "to", "assess", "quantitatively", "morphologic", "changes", "of", "the", "descending", "thoracic", "aorta", "(", "AD", ")", "using", "transesophageal", "echocardiography", "(", "TEE", ")", ".", "Communicating", "dissections", "(", "ca", ")", "were", "present", "in", "16/19", "patients", "with", "operated", "type", "I", "and", "in", "11/23", "patients", "with", "type", "III", "AD", "wherase", "12/23", "type", "III", "AD", "according", "to", "De", "Bakey", "were", "non", "-", "communicating", "(", "nc", ")", ".", "Diametral", "enlargement", "of", "the", "desc", ".", "thoracic", "aorta", "was", "4", "mm", "(", "mean", "value", ")", "at", "1", "year", "in", "all", "patients", ",", "5.9", "mm", "in", "type", "I", "ca", ",", "7.2", "mm", "in", "type", "III", "ca", "but", "only", "3.1", "mm", "in", "type", "III", "nc", "at", "3", "years", ".", "The", "ration", "between", "true", "lumen", "and", "false", "lumen", "(", "FL", ")", "changed", "in", "ca", "AD", "from", "1:2", "to", "1:3", "over", "the", "period", "of", "3", "years", "but", "remained", "constant", "at", "1:1", "in", "ncAD", ".", "Progressive", "thrombosis", "of", "the", "false", "lumen", "(", "FL", ")", "occurred", "in", "76", "%", "of", "patients", "but", "complete", "thrombosis", "of", "the", "FL", "occurred", "in", "only", "6", "%", "of", "type", "I", "ca", ",", "18", "%", "type", "III", "ca", "but", "in", "84", "%", "of", "type", "III", "nc", "patients", "." ]
[ "umlsterm" ]
cyclooxygenase ( COX)-2 is a GENE-Y, COX-2 is a GENE-Y
11078056_task0
Sentence: Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y
[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia.
[ "Biochemistry", "of", "cyclooxygenase", "(", "COX)-2", "inhibitors", "and", "molecular", "pathology", "of", "COX-2", "in", "neoplasia", "." ]
[ "GENE-Y", "CHEMICAL" ]
cyclooxygenase ( COX)-2 is a GENE-Y, COX-2 is a GENE-Y
11078056_task1
Sentence: Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Instructions: please typing these entity words according to sentence: cyclooxygenase ( COX)-2, COX-2 Options: GENE-Y
[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia.
[ "Biochemistry", "of", "cyclooxygenase", "(", "COX)-2", "inhibitors", "and", "molecular", "pathology", "of", "COX-2", "in", "neoplasia", "." ]
[ "GENE-Y", "CHEMICAL" ]
cyclooxygenase ( COX)-2, COX-2
11078056_task2
Sentence: Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia.
[ "Biochemistry", "of", "cyclooxygenase", "(", "COX)-2", "inhibitors", "and", "molecular", "pathology", "of", "COX-2", "in", "neoplasia", "." ]
[ "GENE-Y", "CHEMICAL" ]
Patienten is an umlsterm, Bandscheibenvorfall is an umlsterm, Psychosomatische Stoerung is an umlsterm, Patienten is an umlsterm, Literatur is an umlsterm, Behandlung is an umlsterm
DerSchmerz.70110172.ger.abstr_task0
Sentence: In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert .
[ "In", "einer", "prospektiven", "Studie", "wurden", "30", "Patienten", "mit", "lumbalem", "Bandscheibenvorfall", "und", "typischer", "neurologischer", "Symptomatik", "hinsichtlich", "der", "Praediktoren", "des", "Operationserfolgs", "nach", "15", "Monaten", "untersucht", ".", "Auf", "der", "Grundlage", "ausgewaehlter", "Skalen", "des", "Giessener", "Beschwerdebogens", "und", "des", "Merkmals", "\"", "Psychosomatische", "Stoerung", "in", "der", "Anamnese", "\"", "konnte", "bei", "ca", ".", "90", "%", "der", "Patienten", "der", "Operationserfolg", "korrekt", "vorhergesagt", "werden", ".", "Andere", "Parameter", ",", "z.", "B.", "testpsychologisch", "feststellbare", "Persoenlichkeitsmerkmale", "sowie", "demographische", "und", "medizinische", "Parameter", "hatten", "keinen", "praediktiven", "Wert", ".", "Das", "grosse", "Gewicht", "der", "Neigung", "zur", "somatischen", "Verabeitung", "psychischer", "Spannungen", "fuer", "den", "Operationserfolg", "findet", "sich", "in", "der", "Literatur", "bestaetigt", ".", "Die", "Bedeutung", "dieses", "Befunds", "fuer", "die", "Krankheitsverarbeitung", "wird", "vor", "dem", "Hintergrund", "des", "Konzepts", "von", "Somatisieren", "\"", "vs", ".", "\"", "\"", "Symbolisieren", "\"", "eroertert", ",", "die", "sich", "daraus", "ergebenden", "Folgerungen", "fuer", "die", "Behandlung", "werden", "diskutiert", "." ]
[ "umlsterm" ]
Patienten is an umlsterm, Bandscheibenvorfall is an umlsterm, Psychosomatische Stoerung is an umlsterm, Patienten is an umlsterm, Literatur is an umlsterm, Behandlung is an umlsterm
DerSchmerz.70110172.ger.abstr_task1
Sentence: In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert . Instructions: please typing these entity words according to sentence: Patienten, Bandscheibenvorfall, Psychosomatische Stoerung, Patienten, Literatur, Behandlung Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert .
[ "In", "einer", "prospektiven", "Studie", "wurden", "30", "Patienten", "mit", "lumbalem", "Bandscheibenvorfall", "und", "typischer", "neurologischer", "Symptomatik", "hinsichtlich", "der", "Praediktoren", "des", "Operationserfolgs", "nach", "15", "Monaten", "untersucht", ".", "Auf", "der", "Grundlage", "ausgewaehlter", "Skalen", "des", "Giessener", "Beschwerdebogens", "und", "des", "Merkmals", "\"", "Psychosomatische", "Stoerung", "in", "der", "Anamnese", "\"", "konnte", "bei", "ca", ".", "90", "%", "der", "Patienten", "der", "Operationserfolg", "korrekt", "vorhergesagt", "werden", ".", "Andere", "Parameter", ",", "z.", "B.", "testpsychologisch", "feststellbare", "Persoenlichkeitsmerkmale", "sowie", "demographische", "und", "medizinische", "Parameter", "hatten", "keinen", "praediktiven", "Wert", ".", "Das", "grosse", "Gewicht", "der", "Neigung", "zur", "somatischen", "Verabeitung", "psychischer", "Spannungen", "fuer", "den", "Operationserfolg", "findet", "sich", "in", "der", "Literatur", "bestaetigt", ".", "Die", "Bedeutung", "dieses", "Befunds", "fuer", "die", "Krankheitsverarbeitung", "wird", "vor", "dem", "Hintergrund", "des", "Konzepts", "von", "Somatisieren", "\"", "vs", ".", "\"", "\"", "Symbolisieren", "\"", "eroertert", ",", "die", "sich", "daraus", "ergebenden", "Folgerungen", "fuer", "die", "Behandlung", "werden", "diskutiert", "." ]
[ "umlsterm" ]
Patienten, Bandscheibenvorfall, Psychosomatische Stoerung, Patienten, Literatur, Behandlung
DerSchmerz.70110172.ger.abstr_task2
Sentence: In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
In einer prospektiven Studie wurden 30 Patienten mit lumbalem Bandscheibenvorfall und typischer neurologischer Symptomatik hinsichtlich der Praediktoren des Operationserfolgs nach 15 Monaten untersucht . Auf der Grundlage ausgewaehlter Skalen des Giessener Beschwerdebogens und des Merkmals " Psychosomatische Stoerung in der Anamnese " konnte bei ca. 90% der Patienten der Operationserfolg korrekt vorhergesagt werden . Andere Parameter , z.B. testpsychologisch feststellbare Persoenlichkeitsmerkmale sowie demographische und medizinische Parameter hatten keinen praediktiven Wert . Das grosse Gewicht der Neigung zur somatischen Verabeitung psychischer Spannungen fuer den Operationserfolg findet sich in der Literatur bestaetigt . Die Bedeutung dieses Befunds fuer die Krankheitsverarbeitung wird vor dem Hintergrund des Konzepts von Somatisieren " vs. " " Symbolisieren " eroertert , die sich daraus ergebenden Folgerungen fuer die Behandlung werden diskutiert .
[ "In", "einer", "prospektiven", "Studie", "wurden", "30", "Patienten", "mit", "lumbalem", "Bandscheibenvorfall", "und", "typischer", "neurologischer", "Symptomatik", "hinsichtlich", "der", "Praediktoren", "des", "Operationserfolgs", "nach", "15", "Monaten", "untersucht", ".", "Auf", "der", "Grundlage", "ausgewaehlter", "Skalen", "des", "Giessener", "Beschwerdebogens", "und", "des", "Merkmals", "\"", "Psychosomatische", "Stoerung", "in", "der", "Anamnese", "\"", "konnte", "bei", "ca", ".", "90", "%", "der", "Patienten", "der", "Operationserfolg", "korrekt", "vorhergesagt", "werden", ".", "Andere", "Parameter", ",", "z.", "B.", "testpsychologisch", "feststellbare", "Persoenlichkeitsmerkmale", "sowie", "demographische", "und", "medizinische", "Parameter", "hatten", "keinen", "praediktiven", "Wert", ".", "Das", "grosse", "Gewicht", "der", "Neigung", "zur", "somatischen", "Verabeitung", "psychischer", "Spannungen", "fuer", "den", "Operationserfolg", "findet", "sich", "in", "der", "Literatur", "bestaetigt", ".", "Die", "Bedeutung", "dieses", "Befunds", "fuer", "die", "Krankheitsverarbeitung", "wird", "vor", "dem", "Hintergrund", "des", "Konzepts", "von", "Somatisieren", "\"", "vs", ".", "\"", "\"", "Symbolisieren", "\"", "eroertert", ",", "die", "sich", "daraus", "ergebenden", "Folgerungen", "fuer", "die", "Behandlung", "werden", "diskutiert", "." ]
[ "umlsterm" ]
Strahlentherapie is an umlsterm, Knochenmetastasen is an umlsterm, Beurteilung is an umlsterm, Analyse is an umlsterm, Schmerzlinderung is an umlsterm, Wiederherstellung is an umlsterm, Knochenintegritaet is an umlsterm, radioonkologischer is an umlsterm, Therapiemassnahmen is an umlsterm, Lebensqualitaet is an umlsterm, Tumoraussaat is an umlsterm, Lebenserwartung is an umlsterm, Lebensqualitaet is an umlsterm, Metastase is an umlsterm, Radiotherapie is an umlsterm, Schmerzlinderung is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Radiotherapie is an umlsterm, Rebestrahlung is an umlsterm, Schmerzprogredienz is an umlsterm, Patienten is an umlsterm, frakturgefaehrdeten is an umlsterm, Osteolyse is an umlsterm, Tumoranteilen is an umlsterm, Osteolysen is an umlsterm, Patienten is an umlsterm, Frakturgefahr is an umlsterm
DerOrthopaede.80270245.ger.abstr_task0
Sentence: Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen .
[ "Die", "lokale", "Strahlentherapie", "hat", "einen", "hohen", "Stellenwert", "in", "der", "palliativen", "Bestrahlung", "von", "Knochenmetastasen", ".", "Unterschiedliche", "Dosisfraktionierungskonzepte", "stehen", "zur", "Verfuegung", ".", "Die", "Beurteilung", "der", "Effektivitaet", "solcher", "Konzepte", "muss", "sich", "an", "dem", "palliativen", "Behandlungsziel", "orientieren", ".", "Eine", "Analyse", "publizierter", "Daten", "ist", "auf", "der", "Basis", "von", "Schmerzlinderung", "und", "Wiederherstellung", "der", "Knochenintegritaet", "moeglich", ".", "Studien", "die", "eine", "individuelle", "Stratifizierung", "radioonkologischer", "Therapiemassnahmen", ",", "entsprechend", "dem", "Ziel", "einer", "optimierten", "Lebensqualitaet", "gestatten", ",", "fehlen", ".", "Beurteilungsbasis", "fuer", "die", "Indikationsstellung", "ist", "der", "Grad", "der", "Tumoraussaat", ",", "die", "Lebenserwartung", ",", "die", "Art", "der", "die", "Lebensqualitaet", "einschraenkenden", "Symptomatik", "und", "die", "Lokalisation", "der", "zu", "bestrahlenden", "Metastase", ".", "Anhand", "der", "Extreme", "der", "Indikationsstellung", "zur", "Radiotherapie", "kann", "die", "Effektivitaet", "dieser", "Massnahme", "dargelegt", "werden", ".", "Allein", "das", "Ziel", "der", "Schmerzlinderung", "bei", "infauster", "Prognose", "kann", "mit", "einer", "einmaligen", "Einzeldosis", "von", "8", "Gy", "erreicht", "werden", ".", "Mehr", "als", "70", "%", "der", "Patienten", "zeigen", "unabhaengig", "vom", "gewaehlten", "Bestrahlungskonzept", "ein", "Ansprechen", ".", "Die", "Ansprechzeit", "wird", "bei", "einmaliger", "Radiotherapie", "verkuerzt", ".", "Eine", "Rebestrahlung", "bei", "erneuter", "Schmerzprogredienz", "weist", "die", "gleiche", "Effektivitaet", "auf", "und", "relativiert", "die", "kuerzere", "Remissionszeit", ".", "Patienten", "mit", "frakturgefaehrdeten", "Osteolyse", "oder", "intraspinalen", "Tumoranteilen", "muessen", "mit", "dem", "Ziel", "der", "maximalen", "Tumorzellzerstoerung", "mit", "kurativer", "\"", "Dosis", "\"", "behandelt", "werden", ".", "Eine", "Rekalzifizierung", "der", "Osteolysen", "ist", "bei", "60", "-", "80", "%", "der", "Patienten", "nach", "4", "-", "8", "Wochen", "moeglich", ".", "Eine", "orthetische", "Versorgung", "ist", "bei", "Frakturgefahr", "zwingend", "notwendig", ".", "Akzelerierte", "Fraktionierungskonzepte", "koennen", "die", "Rekalzifizierung", "nicht", "beschleunigen", "." ]
[ "umlsterm" ]
Strahlentherapie is an umlsterm, Knochenmetastasen is an umlsterm, Beurteilung is an umlsterm, Analyse is an umlsterm, Schmerzlinderung is an umlsterm, Wiederherstellung is an umlsterm, Knochenintegritaet is an umlsterm, radioonkologischer is an umlsterm, Therapiemassnahmen is an umlsterm, Lebensqualitaet is an umlsterm, Tumoraussaat is an umlsterm, Lebenserwartung is an umlsterm, Lebensqualitaet is an umlsterm, Metastase is an umlsterm, Radiotherapie is an umlsterm, Schmerzlinderung is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Radiotherapie is an umlsterm, Rebestrahlung is an umlsterm, Schmerzprogredienz is an umlsterm, Patienten is an umlsterm, frakturgefaehrdeten is an umlsterm, Osteolyse is an umlsterm, Tumoranteilen is an umlsterm, Osteolysen is an umlsterm, Patienten is an umlsterm, Frakturgefahr is an umlsterm
DerOrthopaede.80270245.ger.abstr_task1
Sentence: Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen . Instructions: please typing these entity words according to sentence: Strahlentherapie, Knochenmetastasen, Beurteilung, Analyse, Schmerzlinderung, Wiederherstellung, Knochenintegritaet, radioonkologischer, Therapiemassnahmen, Lebensqualitaet, Tumoraussaat, Lebenserwartung, Lebensqualitaet, Metastase, Radiotherapie, Schmerzlinderung, Prognose, Patienten, Radiotherapie, Rebestrahlung, Schmerzprogredienz, Patienten, frakturgefaehrdeten, Osteolyse, Tumoranteilen, Osteolysen, Patienten, Frakturgefahr Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen .
[ "Die", "lokale", "Strahlentherapie", "hat", "einen", "hohen", "Stellenwert", "in", "der", "palliativen", "Bestrahlung", "von", "Knochenmetastasen", ".", "Unterschiedliche", "Dosisfraktionierungskonzepte", "stehen", "zur", "Verfuegung", ".", "Die", "Beurteilung", "der", "Effektivitaet", "solcher", "Konzepte", "muss", "sich", "an", "dem", "palliativen", "Behandlungsziel", "orientieren", ".", "Eine", "Analyse", "publizierter", "Daten", "ist", "auf", "der", "Basis", "von", "Schmerzlinderung", "und", "Wiederherstellung", "der", "Knochenintegritaet", "moeglich", ".", "Studien", "die", "eine", "individuelle", "Stratifizierung", "radioonkologischer", "Therapiemassnahmen", ",", "entsprechend", "dem", "Ziel", "einer", "optimierten", "Lebensqualitaet", "gestatten", ",", "fehlen", ".", "Beurteilungsbasis", "fuer", "die", "Indikationsstellung", "ist", "der", "Grad", "der", "Tumoraussaat", ",", "die", "Lebenserwartung", ",", "die", "Art", "der", "die", "Lebensqualitaet", "einschraenkenden", "Symptomatik", "und", "die", "Lokalisation", "der", "zu", "bestrahlenden", "Metastase", ".", "Anhand", "der", "Extreme", "der", "Indikationsstellung", "zur", "Radiotherapie", "kann", "die", "Effektivitaet", "dieser", "Massnahme", "dargelegt", "werden", ".", "Allein", "das", "Ziel", "der", "Schmerzlinderung", "bei", "infauster", "Prognose", "kann", "mit", "einer", "einmaligen", "Einzeldosis", "von", "8", "Gy", "erreicht", "werden", ".", "Mehr", "als", "70", "%", "der", "Patienten", "zeigen", "unabhaengig", "vom", "gewaehlten", "Bestrahlungskonzept", "ein", "Ansprechen", ".", "Die", "Ansprechzeit", "wird", "bei", "einmaliger", "Radiotherapie", "verkuerzt", ".", "Eine", "Rebestrahlung", "bei", "erneuter", "Schmerzprogredienz", "weist", "die", "gleiche", "Effektivitaet", "auf", "und", "relativiert", "die", "kuerzere", "Remissionszeit", ".", "Patienten", "mit", "frakturgefaehrdeten", "Osteolyse", "oder", "intraspinalen", "Tumoranteilen", "muessen", "mit", "dem", "Ziel", "der", "maximalen", "Tumorzellzerstoerung", "mit", "kurativer", "\"", "Dosis", "\"", "behandelt", "werden", ".", "Eine", "Rekalzifizierung", "der", "Osteolysen", "ist", "bei", "60", "-", "80", "%", "der", "Patienten", "nach", "4", "-", "8", "Wochen", "moeglich", ".", "Eine", "orthetische", "Versorgung", "ist", "bei", "Frakturgefahr", "zwingend", "notwendig", ".", "Akzelerierte", "Fraktionierungskonzepte", "koennen", "die", "Rekalzifizierung", "nicht", "beschleunigen", "." ]
[ "umlsterm" ]
Strahlentherapie, Knochenmetastasen, Beurteilung, Analyse, Schmerzlinderung, Wiederherstellung, Knochenintegritaet, radioonkologischer, Therapiemassnahmen, Lebensqualitaet, Tumoraussaat, Lebenserwartung, Lebensqualitaet, Metastase, Radiotherapie, Schmerzlinderung, Prognose, Patienten, Radiotherapie, Rebestrahlung, Schmerzprogredienz, Patienten, frakturgefaehrdeten, Osteolyse, Tumoranteilen, Osteolysen, Patienten, Frakturgefahr
DerOrthopaede.80270245.ger.abstr_task2
Sentence: Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die lokale Strahlentherapie hat einen hohen Stellenwert in der palliativen Bestrahlung von Knochenmetastasen . Unterschiedliche Dosisfraktionierungskonzepte stehen zur Verfuegung . Die Beurteilung der Effektivitaet solcher Konzepte muss sich an dem palliativen Behandlungsziel orientieren . Eine Analyse publizierter Daten ist auf der Basis von Schmerzlinderung und Wiederherstellung der Knochenintegritaet moeglich . Studien die eine individuelle Stratifizierung radioonkologischer Therapiemassnahmen , entsprechend dem Ziel einer optimierten Lebensqualitaet gestatten , fehlen . Beurteilungsbasis fuer die Indikationsstellung ist der Grad der Tumoraussaat , die Lebenserwartung , die Art der die Lebensqualitaet einschraenkenden Symptomatik und die Lokalisation der zu bestrahlenden Metastase . Anhand der Extreme der Indikationsstellung zur Radiotherapie kann die Effektivitaet dieser Massnahme dargelegt werden . Allein das Ziel der Schmerzlinderung bei infauster Prognose kann mit einer einmaligen Einzeldosis von 8 Gy erreicht werden . Mehr als 70 % der Patienten zeigen unabhaengig vom gewaehlten Bestrahlungskonzept ein Ansprechen . Die Ansprechzeit wird bei einmaliger Radiotherapie verkuerzt . Eine Rebestrahlung bei erneuter Schmerzprogredienz weist die gleiche Effektivitaet auf und relativiert die kuerzere Remissionszeit . Patienten mit frakturgefaehrdeten Osteolyse oder intraspinalen Tumoranteilen muessen mit dem Ziel der maximalen Tumorzellzerstoerung mit kurativer " Dosis " behandelt werden . Eine Rekalzifizierung der Osteolysen ist bei 60-80 % der Patienten nach 4-8 Wochen moeglich . Eine orthetische Versorgung ist bei Frakturgefahr zwingend notwendig . Akzelerierte Fraktionierungskonzepte koennen die Rekalzifizierung nicht beschleunigen .
[ "Die", "lokale", "Strahlentherapie", "hat", "einen", "hohen", "Stellenwert", "in", "der", "palliativen", "Bestrahlung", "von", "Knochenmetastasen", ".", "Unterschiedliche", "Dosisfraktionierungskonzepte", "stehen", "zur", "Verfuegung", ".", "Die", "Beurteilung", "der", "Effektivitaet", "solcher", "Konzepte", "muss", "sich", "an", "dem", "palliativen", "Behandlungsziel", "orientieren", ".", "Eine", "Analyse", "publizierter", "Daten", "ist", "auf", "der", "Basis", "von", "Schmerzlinderung", "und", "Wiederherstellung", "der", "Knochenintegritaet", "moeglich", ".", "Studien", "die", "eine", "individuelle", "Stratifizierung", "radioonkologischer", "Therapiemassnahmen", ",", "entsprechend", "dem", "Ziel", "einer", "optimierten", "Lebensqualitaet", "gestatten", ",", "fehlen", ".", "Beurteilungsbasis", "fuer", "die", "Indikationsstellung", "ist", "der", "Grad", "der", "Tumoraussaat", ",", "die", "Lebenserwartung", ",", "die", "Art", "der", "die", "Lebensqualitaet", "einschraenkenden", "Symptomatik", "und", "die", "Lokalisation", "der", "zu", "bestrahlenden", "Metastase", ".", "Anhand", "der", "Extreme", "der", "Indikationsstellung", "zur", "Radiotherapie", "kann", "die", "Effektivitaet", "dieser", "Massnahme", "dargelegt", "werden", ".", "Allein", "das", "Ziel", "der", "Schmerzlinderung", "bei", "infauster", "Prognose", "kann", "mit", "einer", "einmaligen", "Einzeldosis", "von", "8", "Gy", "erreicht", "werden", ".", "Mehr", "als", "70", "%", "der", "Patienten", "zeigen", "unabhaengig", "vom", "gewaehlten", "Bestrahlungskonzept", "ein", "Ansprechen", ".", "Die", "Ansprechzeit", "wird", "bei", "einmaliger", "Radiotherapie", "verkuerzt", ".", "Eine", "Rebestrahlung", "bei", "erneuter", "Schmerzprogredienz", "weist", "die", "gleiche", "Effektivitaet", "auf", "und", "relativiert", "die", "kuerzere", "Remissionszeit", ".", "Patienten", "mit", "frakturgefaehrdeten", "Osteolyse", "oder", "intraspinalen", "Tumoranteilen", "muessen", "mit", "dem", "Ziel", "der", "maximalen", "Tumorzellzerstoerung", "mit", "kurativer", "\"", "Dosis", "\"", "behandelt", "werden", ".", "Eine", "Rekalzifizierung", "der", "Osteolysen", "ist", "bei", "60", "-", "80", "%", "der", "Patienten", "nach", "4", "-", "8", "Wochen", "moeglich", ".", "Eine", "orthetische", "Versorgung", "ist", "bei", "Frakturgefahr", "zwingend", "notwendig", ".", "Akzelerierte", "Fraktionierungskonzepte", "koennen", "die", "Rekalzifizierung", "nicht", "beschleunigen", "." ]
[ "umlsterm" ]
Vasodilator - stimulated phosphoprotein is a Gene_or_gene_product, stress - fiber is a Cellular_component, membrane ruffle is a Cellular_component, endothelial cells is a Cell, Vasodilator - stimulated phosphoprotein is a Gene_or_gene_product, VASP is a Gene_or_gene_product, vascular endothelial cells is a Cell, vessel is a Multi-tissue_structure, VASP is a Gene_or_gene_product, VASP is a Gene_or_gene_product, endothelial cells is a Cell, VASP is a Gene_or_gene_product, membrane is a Cellular_component, stress fibers is a Cellular_component, bovine is a Organism, aortic endothelial cells is a Cell, proline - rich domain is a Protein_domain_or_region, VASP is a Gene_or_gene_product, profilin is a Gene_or_gene_product, stress fiber is a Cellular_component, VASP is a Gene_or_gene_product, zyxin is a Gene_or_gene_product, vinculin is a Gene_or_gene_product, subdomains is a Protein_domain_or_region, VASP is a Gene_or_gene_product, F - actin is a Gene_or_gene_product, actin is a Gene_or_gene_product, endothelial cell - substrate is a Cellular_component, cell - cell contacts is a Cellular_component, VASP is a Gene_or_gene_product, endothelial is a Cell, capillary is a Tissue, vascular is a Multi-tissue_structure, endothelial cell is a Cell
25_task0
Sentence: Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Gene_or_gene_product, Cellular_component, Protein_domain_or_region, Organism, Multi-tissue_structure, Cell
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "B-Organism", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "B-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O" ]
Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility.
[ "Vasodilator", "-", "stimulated", "phosphoprotein", "is", "involved", "in", "stress", "-", "fiber", "and", "membrane", "ruffle", "formation", "in", "endothelial", "cells", ".", "\n\n", "Vasodilator", "-", "stimulated", "phosphoprotein", "(", "VASP", ")", "is", "highly", "expressed", "in", "vascular", "endothelial", "cells", ",", "where", "it", "has", "been", "implicated", "in", "cellular", "reorganization", "during", "angiogenesis", ",", "as", "well", "as", "in", "endothelial", "retraction", "and", "changes", "in", "vessel", "permeability", ".", "However", ",", "the", "cellular", "functions", "of", "VASP", "are", "not", "known", ".", "In", "this", "study", ",", "we", "have", "expressed", "wild", "-", "type", "and", "mutant", "forms", "of", "VASP", "in", "endothelial", "cells", "to", "determine", "in", "what", "aspects", "of", "cytoskeletal", "behavior", "this", "protein", "participates", ".", "Expression", "of", "wild", "-", "type", "VASP", "induces", "marked", "membrane", "ruffling", "and", "formation", "of", "prominent", "stress", "fibers", "in", "bovine", "aortic", "endothelial", "cells", ".", "Deletion", "of", "the", "proline", "-", "rich", "domain", "of", "VASP", "abolishes", "its", "ability", "to", "bind", "profilin", "but", "does", "not", "affect", "ruffling", "or", "stress", "fiber", "formation", ".", "Further", "deletions", "reveal", "a", "sequence", "within", "the", "carboxy", "-", "terminal", "domain", "that", "is", "responsible", "for", "in", "vivo", "bundle", "formation", ".", "Ruffling", "occurs", "only", "on", "the", "expression", "of", "forms", "of", "VASP", "that", "possess", "bundling", "activity", "and", "the", "capacity", "to", "bind", "zyxin", "/", "vinculin", "-", "derived", "peptide", ".", "The", "ability", "of", "distinct", "subdomains", "within", "VASP", "to", "bind", "adhesion", "proteins", "and", "induce", "F", "-", "actin", "bundling", "in", "vivo", "suggests", "that", "this", "protein", "could", "function", "in", "the", "aggregation", "and", "tethering", "of", "actin", "filaments", "during", "the", "formation", "of", "endothelial", "cell", "-", "substrate", "and", "cell", "-", "cell", "contacts", ".", "These", "data", "provide", "a", "mechanism", "whereby", "VASP", "can", "influence", "endothelial", "migration", "and", "organization", "during", "capillary", "formation", "and", "modulate", "vascular", "permeability", "via", "effects", "on", "endothelial", "cell", "contractility", ".", "\n" ]
[ "Gene_or_gene_product", "Cell", "Cellular_component", "Protein_domain_or_region", "Tissue", "Multi-tissue_structure", "Organism" ]
Vasodilator - stimulated phosphoprotein is a Gene_or_gene_product, stress - fiber is a Cellular_component, membrane ruffle is a Cellular_component, endothelial cells is a Cell, Vasodilator - stimulated phosphoprotein is a Gene_or_gene_product, VASP is a Gene_or_gene_product, vascular endothelial cells is a Cell, vessel is a Multi-tissue_structure, VASP is a Gene_or_gene_product, VASP is a Gene_or_gene_product, endothelial cells is a Cell, VASP is a Gene_or_gene_product, membrane is a Cellular_component, stress fibers is a Cellular_component, bovine is a Organism, aortic endothelial cells is a Cell, proline - rich domain is a Protein_domain_or_region, VASP is a Gene_or_gene_product, profilin is a Gene_or_gene_product, stress fiber is a Cellular_component, VASP is a Gene_or_gene_product, zyxin is a Gene_or_gene_product, vinculin is a Gene_or_gene_product, subdomains is a Protein_domain_or_region, VASP is a Gene_or_gene_product, F - actin is a Gene_or_gene_product, actin is a Gene_or_gene_product, endothelial cell - substrate is a Cellular_component, cell - cell contacts is a Cellular_component, VASP is a Gene_or_gene_product, endothelial is a Cell, capillary is a Tissue, vascular is a Multi-tissue_structure, endothelial cell is a Cell
25_task1
Sentence: Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility. Instructions: please typing these entity words according to sentence: Vasodilator - stimulated phosphoprotein, stress - fiber, membrane ruffle, endothelial cells, Vasodilator - stimulated phosphoprotein, VASP, vascular endothelial cells, vessel, VASP, VASP, endothelial cells, VASP, membrane, stress fibers, bovine, aortic endothelial cells, proline - rich domain, VASP, profilin, stress fiber, VASP, zyxin, vinculin, subdomains, VASP, F - actin, actin, endothelial cell - substrate, cell - cell contacts, VASP, endothelial, capillary, vascular, endothelial cell Options: Tissue, Gene_or_gene_product, Cellular_component, Protein_domain_or_region, Organism, Multi-tissue_structure, Cell
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "B-Organism", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "B-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O" ]
Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility.
[ "Vasodilator", "-", "stimulated", "phosphoprotein", "is", "involved", "in", "stress", "-", "fiber", "and", "membrane", "ruffle", "formation", "in", "endothelial", "cells", ".", "\n\n", "Vasodilator", "-", "stimulated", "phosphoprotein", "(", "VASP", ")", "is", "highly", "expressed", "in", "vascular", "endothelial", "cells", ",", "where", "it", "has", "been", "implicated", "in", "cellular", "reorganization", "during", "angiogenesis", ",", "as", "well", "as", "in", "endothelial", "retraction", "and", "changes", "in", "vessel", "permeability", ".", "However", ",", "the", "cellular", "functions", "of", "VASP", "are", "not", "known", ".", "In", "this", "study", ",", "we", "have", "expressed", "wild", "-", "type", "and", "mutant", "forms", "of", "VASP", "in", "endothelial", "cells", "to", "determine", "in", "what", "aspects", "of", "cytoskeletal", "behavior", "this", "protein", "participates", ".", "Expression", "of", "wild", "-", "type", "VASP", "induces", "marked", "membrane", "ruffling", "and", "formation", "of", "prominent", "stress", "fibers", "in", "bovine", "aortic", "endothelial", "cells", ".", "Deletion", "of", "the", "proline", "-", "rich", "domain", "of", "VASP", "abolishes", "its", "ability", "to", "bind", "profilin", "but", "does", "not", "affect", "ruffling", "or", "stress", "fiber", "formation", ".", "Further", "deletions", "reveal", "a", "sequence", "within", "the", "carboxy", "-", "terminal", "domain", "that", "is", "responsible", "for", "in", "vivo", "bundle", "formation", ".", "Ruffling", "occurs", "only", "on", "the", "expression", "of", "forms", "of", "VASP", "that", "possess", "bundling", "activity", "and", "the", "capacity", "to", "bind", "zyxin", "/", "vinculin", "-", "derived", "peptide", ".", "The", "ability", "of", "distinct", "subdomains", "within", "VASP", "to", "bind", "adhesion", "proteins", "and", "induce", "F", "-", "actin", "bundling", "in", "vivo", "suggests", "that", "this", "protein", "could", "function", "in", "the", "aggregation", "and", "tethering", "of", "actin", "filaments", "during", "the", "formation", "of", "endothelial", "cell", "-", "substrate", "and", "cell", "-", "cell", "contacts", ".", "These", "data", "provide", "a", "mechanism", "whereby", "VASP", "can", "influence", "endothelial", "migration", "and", "organization", "during", "capillary", "formation", "and", "modulate", "vascular", "permeability", "via", "effects", "on", "endothelial", "cell", "contractility", ".", "\n" ]
[ "Gene_or_gene_product", "Cell", "Cellular_component", "Protein_domain_or_region", "Tissue", "Multi-tissue_structure", "Organism" ]
Vasodilator - stimulated phosphoprotein, stress - fiber, membrane ruffle, endothelial cells, Vasodilator - stimulated phosphoprotein, VASP, vascular endothelial cells, vessel, VASP, VASP, endothelial cells, VASP, membrane, stress fibers, bovine, aortic endothelial cells, proline - rich domain, VASP, profilin, stress fiber, VASP, zyxin, vinculin, subdomains, VASP, F - actin, actin, endothelial cell - substrate, cell - cell contacts, VASP, endothelial, capillary, vascular, endothelial cell
25_task2
Sentence: Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility. Instructions: please extract entity words from the input sentence
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "B-Organism", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "B-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "I-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein_domain_or_region", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "B-Cellular_component", "I-Cellular_component", "I-Cellular_component", "I-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O" ]
Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability. However, the cellular functions of VASP are not known. In this study, we have expressed wild-type and mutant forms of VASP in endothelial cells to determine in what aspects of cytoskeletal behavior this protein participates. Expression of wild-type VASP induces marked membrane ruffling and formation of prominent stress fibers in bovine aortic endothelial cells. Deletion of the proline-rich domain of VASP abolishes its ability to bind profilin but does not affect ruffling or stress fiber formation. Further deletions reveal a sequence within the carboxy-terminal domain that is responsible for in vivo bundle formation. Ruffling occurs only on the expression of forms of VASP that possess bundling activity and the capacity to bind zyxin/vinculin-derived peptide. The ability of distinct subdomains within VASP to bind adhesion proteins and induce F-actin bundling in vivo suggests that this protein could function in the aggregation and tethering of actin filaments during the formation of endothelial cell-substrate and cell-cell contacts. These data provide a mechanism whereby VASP can influence endothelial migration and organization during capillary formation and modulate vascular permeability via effects on endothelial cell contractility.
[ "Vasodilator", "-", "stimulated", "phosphoprotein", "is", "involved", "in", "stress", "-", "fiber", "and", "membrane", "ruffle", "formation", "in", "endothelial", "cells", ".", "\n\n", "Vasodilator", "-", "stimulated", "phosphoprotein", "(", "VASP", ")", "is", "highly", "expressed", "in", "vascular", "endothelial", "cells", ",", "where", "it", "has", "been", "implicated", "in", "cellular", "reorganization", "during", "angiogenesis", ",", "as", "well", "as", "in", "endothelial", "retraction", "and", "changes", "in", "vessel", "permeability", ".", "However", ",", "the", "cellular", "functions", "of", "VASP", "are", "not", "known", ".", "In", "this", "study", ",", "we", "have", "expressed", "wild", "-", "type", "and", "mutant", "forms", "of", "VASP", "in", "endothelial", "cells", "to", "determine", "in", "what", "aspects", "of", "cytoskeletal", "behavior", "this", "protein", "participates", ".", "Expression", "of", "wild", "-", "type", "VASP", "induces", "marked", "membrane", "ruffling", "and", "formation", "of", "prominent", "stress", "fibers", "in", "bovine", "aortic", "endothelial", "cells", ".", "Deletion", "of", "the", "proline", "-", "rich", "domain", "of", "VASP", "abolishes", "its", "ability", "to", "bind", "profilin", "but", "does", "not", "affect", "ruffling", "or", "stress", "fiber", "formation", ".", "Further", "deletions", "reveal", "a", "sequence", "within", "the", "carboxy", "-", "terminal", "domain", "that", "is", "responsible", "for", "in", "vivo", "bundle", "formation", ".", "Ruffling", "occurs", "only", "on", "the", "expression", "of", "forms", "of", "VASP", "that", "possess", "bundling", "activity", "and", "the", "capacity", "to", "bind", "zyxin", "/", "vinculin", "-", "derived", "peptide", ".", "The", "ability", "of", "distinct", "subdomains", "within", "VASP", "to", "bind", "adhesion", "proteins", "and", "induce", "F", "-", "actin", "bundling", "in", "vivo", "suggests", "that", "this", "protein", "could", "function", "in", "the", "aggregation", "and", "tethering", "of", "actin", "filaments", "during", "the", "formation", "of", "endothelial", "cell", "-", "substrate", "and", "cell", "-", "cell", "contacts", ".", "These", "data", "provide", "a", "mechanism", "whereby", "VASP", "can", "influence", "endothelial", "migration", "and", "organization", "during", "capillary", "formation", "and", "modulate", "vascular", "permeability", "via", "effects", "on", "endothelial", "cell", "contractility", ".", "\n" ]
[ "Gene_or_gene_product", "Cell", "Cellular_component", "Protein_domain_or_region", "Tissue", "Multi-tissue_structure", "Organism" ]
intestinal absorption of fructose is a Participant_Condition, sorbitol is a Intervention_Pharmacological, xylitol is a Intervention_Pharmacological, rate of malabsorption is a Outcome_Physical, 25 is a Participant_Sample-size, healthy controls is a Participant_Condition, 25 g of each sugar is a Intervention_Pharmacological, intestinal absorption was determined by H2-exhalation tests is a Outcome_Physical, clinical symptoms is a Outcome_Physical, carbohydrate malabsorption is a Outcome_Physical
82420_task0
Sentence: [ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size
[ "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints .
[ "[", "Carbohydrate", "substitutes", ":", "comparative", "study", "of", "intestinal", "absorption", "of", "fructose", ",", "sorbitol", "and", "xylitol", "]", ".", "BACKGROUND", "The", "carbohydrate", "substitutes", "fructose", ",", "sorbitol", "and", "xylitol", "are", "gaining", "more", "and", "more", "importance", "in", "the", "production", "of", "dietary", "food", ".", "But", "they", "can", "provoke", "gastrointestinal", "side", "-", "effects", ".", "In", "a", "randomized", "double", "blind", "study", "the", "rate", "of", "malabsorption", "of", "these", "sugars", "was", "compared", "and", "the", "concomitant", "symptoms", "were", "recorded", ".", "SUBJECTS", "AND", "METHODS", "25", "healthy", "controls", "received", "25", "g", "of", "each", "sugar", "within", "3", "consecutive", "days", ".", "The", "intestinal", "absorption", "was", "determined", "by", "H2-exhalation", "tests", "and", "the", "clinical", "symptoms", "were", "recorded", ".", "RESULTS", "The", "rate", "of", "malabsorption", "was", "84", "%", "for", "sorbitol", ",", "36", "%", "for", "fructose", "and", "12", "%", "for", "xylitol", "(", "p", "<", "0.01", "for", "sorbitol", "versus", "fructose", "and", "xylitol", ")", ".", "57", "%", "of", "the", "participants", "with", "pathological", "H2-test", "after", "sorbitol", "and", "56", "%", "after", "fructose", "reported", "symptoms", ",", "while", "all", "of", "the", "3", "malabsorbers", "of", "xylitol", "were", "symptomatic", ".", "CONCLUSIONS", "There", "is", "an", "advantage", "to", "administering", "xylitol", "and", "fructose", "with", "regard", "to", "the", "intestinal", "absorption", "and", "concomitant", "symptoms", "as", "compared", "with", "sorbitol", ".", "H2-exhalation", "tests", "appear", "to", "be", "a", "reliable", "diagnostic", "tool", "to", "detect", "carbohydrate", "malabsorption", "and", "should", "find", "broader", "application", "in", "patients", "suffering", "from", "non", "-", "specific", "abdominal", "complaints", "." ]
[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
intestinal absorption of fructose is a Participant_Condition, sorbitol is a Intervention_Pharmacological, xylitol is a Intervention_Pharmacological, rate of malabsorption is a Outcome_Physical, 25 is a Participant_Sample-size, healthy controls is a Participant_Condition, 25 g of each sugar is a Intervention_Pharmacological, intestinal absorption was determined by H2-exhalation tests is a Outcome_Physical, clinical symptoms is a Outcome_Physical, carbohydrate malabsorption is a Outcome_Physical
82420_task1
Sentence: [ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints . Instructions: please typing these entity words according to sentence: intestinal absorption of fructose, sorbitol, xylitol, rate of malabsorption, 25, healthy controls, 25 g of each sugar, intestinal absorption was determined by H2-exhalation tests, clinical symptoms, carbohydrate malabsorption Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size
[ "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints .
[ "[", "Carbohydrate", "substitutes", ":", "comparative", "study", "of", "intestinal", "absorption", "of", "fructose", ",", "sorbitol", "and", "xylitol", "]", ".", "BACKGROUND", "The", "carbohydrate", "substitutes", "fructose", ",", "sorbitol", "and", "xylitol", "are", "gaining", "more", "and", "more", "importance", "in", "the", "production", "of", "dietary", "food", ".", "But", "they", "can", "provoke", "gastrointestinal", "side", "-", "effects", ".", "In", "a", "randomized", "double", "blind", "study", "the", "rate", "of", "malabsorption", "of", "these", "sugars", "was", "compared", "and", "the", "concomitant", "symptoms", "were", "recorded", ".", "SUBJECTS", "AND", "METHODS", "25", "healthy", "controls", "received", "25", "g", "of", "each", "sugar", "within", "3", "consecutive", "days", ".", "The", "intestinal", "absorption", "was", "determined", "by", "H2-exhalation", "tests", "and", "the", "clinical", "symptoms", "were", "recorded", ".", "RESULTS", "The", "rate", "of", "malabsorption", "was", "84", "%", "for", "sorbitol", ",", "36", "%", "for", "fructose", "and", "12", "%", "for", "xylitol", "(", "p", "<", "0.01", "for", "sorbitol", "versus", "fructose", "and", "xylitol", ")", ".", "57", "%", "of", "the", "participants", "with", "pathological", "H2-test", "after", "sorbitol", "and", "56", "%", "after", "fructose", "reported", "symptoms", ",", "while", "all", "of", "the", "3", "malabsorbers", "of", "xylitol", "were", "symptomatic", ".", "CONCLUSIONS", "There", "is", "an", "advantage", "to", "administering", "xylitol", "and", "fructose", "with", "regard", "to", "the", "intestinal", "absorption", "and", "concomitant", "symptoms", "as", "compared", "with", "sorbitol", ".", "H2-exhalation", "tests", "appear", "to", "be", "a", "reliable", "diagnostic", "tool", "to", "detect", "carbohydrate", "malabsorption", "and", "should", "find", "broader", "application", "in", "patients", "suffering", "from", "non", "-", "specific", "abdominal", "complaints", "." ]
[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
intestinal absorption of fructose, sorbitol, xylitol, rate of malabsorption, 25, healthy controls, 25 g of each sugar, intestinal absorption was determined by H2-exhalation tests, clinical symptoms, carbohydrate malabsorption
82420_task2
Sentence: [ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints .
[ "[", "Carbohydrate", "substitutes", ":", "comparative", "study", "of", "intestinal", "absorption", "of", "fructose", ",", "sorbitol", "and", "xylitol", "]", ".", "BACKGROUND", "The", "carbohydrate", "substitutes", "fructose", ",", "sorbitol", "and", "xylitol", "are", "gaining", "more", "and", "more", "importance", "in", "the", "production", "of", "dietary", "food", ".", "But", "they", "can", "provoke", "gastrointestinal", "side", "-", "effects", ".", "In", "a", "randomized", "double", "blind", "study", "the", "rate", "of", "malabsorption", "of", "these", "sugars", "was", "compared", "and", "the", "concomitant", "symptoms", "were", "recorded", ".", "SUBJECTS", "AND", "METHODS", "25", "healthy", "controls", "received", "25", "g", "of", "each", "sugar", "within", "3", "consecutive", "days", ".", "The", "intestinal", "absorption", "was", "determined", "by", "H2-exhalation", "tests", "and", "the", "clinical", "symptoms", "were", "recorded", ".", "RESULTS", "The", "rate", "of", "malabsorption", "was", "84", "%", "for", "sorbitol", ",", "36", "%", "for", "fructose", "and", "12", "%", "for", "xylitol", "(", "p", "<", "0.01", "for", "sorbitol", "versus", "fructose", "and", "xylitol", ")", ".", "57", "%", "of", "the", "participants", "with", "pathological", "H2-test", "after", "sorbitol", "and", "56", "%", "after", "fructose", "reported", "symptoms", ",", "while", "all", "of", "the", "3", "malabsorbers", "of", "xylitol", "were", "symptomatic", ".", "CONCLUSIONS", "There", "is", "an", "advantage", "to", "administering", "xylitol", "and", "fructose", "with", "regard", "to", "the", "intestinal", "absorption", "and", "concomitant", "symptoms", "as", "compared", "with", "sorbitol", ".", "H2-exhalation", "tests", "appear", "to", "be", "a", "reliable", "diagnostic", "tool", "to", "detect", "carbohydrate", "malabsorption", "and", "should", "find", "broader", "application", "in", "patients", "suffering", "from", "non", "-", "specific", "abdominal", "complaints", "." ]
[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
consumption is an umlsterm, set is an umlsterm, drug is an umlsterm, Ecstasy is an umlsterm, MDMA is an umlsterm, people is an umlsterm, complications is an umlsterm, use is an umlsterm, Ecstasy is an umlsterm, Seizures is an umlsterm, complications is an umlsterm, CNS is an umlsterm, Ecstasy is an umlsterm
DerNervenarzt.90701094.eng.abstr_task0
Sentence: The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy .
[ "The", "consumption", "of", "the", "jet", "set", "drug", "Ecstasy", "(", "3,4-methylenedioxymetamphetamine", ",", "abbreviated", "to", "MDMA", ")", "by", "young", "people", "is", "increasing", "markedly", ".", "Parallel", "to", "this", "developement", ",", "there", "is", "a", "large", "number", "of", "reports", "on", "severe", "neurological", ",", "psychiatric", "and", "medical", "complications", "following", "the", "use", "of", "Ecstasy", ".", "Seizures", "are", "among", "the", "most", "common", "clinical", "complications", "of", "the", "CNS", "following", "the", "ingestion", "of", "Ecstasy", "." ]
[ "umlsterm" ]
consumption is an umlsterm, set is an umlsterm, drug is an umlsterm, Ecstasy is an umlsterm, MDMA is an umlsterm, people is an umlsterm, complications is an umlsterm, use is an umlsterm, Ecstasy is an umlsterm, Seizures is an umlsterm, complications is an umlsterm, CNS is an umlsterm, Ecstasy is an umlsterm
DerNervenarzt.90701094.eng.abstr_task1
Sentence: The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy . Instructions: please typing these entity words according to sentence: consumption, set, drug, Ecstasy, MDMA, people, complications, use, Ecstasy, Seizures, complications, CNS, Ecstasy Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy .
[ "The", "consumption", "of", "the", "jet", "set", "drug", "Ecstasy", "(", "3,4-methylenedioxymetamphetamine", ",", "abbreviated", "to", "MDMA", ")", "by", "young", "people", "is", "increasing", "markedly", ".", "Parallel", "to", "this", "developement", ",", "there", "is", "a", "large", "number", "of", "reports", "on", "severe", "neurological", ",", "psychiatric", "and", "medical", "complications", "following", "the", "use", "of", "Ecstasy", ".", "Seizures", "are", "among", "the", "most", "common", "clinical", "complications", "of", "the", "CNS", "following", "the", "ingestion", "of", "Ecstasy", "." ]
[ "umlsterm" ]
consumption, set, drug, Ecstasy, MDMA, people, complications, use, Ecstasy, Seizures, complications, CNS, Ecstasy
DerNervenarzt.90701094.eng.abstr_task2
Sentence: The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
The consumption of the jet set drug Ecstasy ( 3,4-methylenedioxymetamphetamine , abbreviated to MDMA ) by young people is increasing markedly . Parallel to this developement , there is a large number of reports on severe neurological , psychiatric and medical complications following the use of Ecstasy . Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy .
[ "The", "consumption", "of", "the", "jet", "set", "drug", "Ecstasy", "(", "3,4-methylenedioxymetamphetamine", ",", "abbreviated", "to", "MDMA", ")", "by", "young", "people", "is", "increasing", "markedly", ".", "Parallel", "to", "this", "developement", ",", "there", "is", "a", "large", "number", "of", "reports", "on", "severe", "neurological", ",", "psychiatric", "and", "medical", "complications", "following", "the", "use", "of", "Ecstasy", ".", "Seizures", "are", "among", "the", "most", "common", "clinical", "complications", "of", "the", "CNS", "following", "the", "ingestion", "of", "Ecstasy", "." ]
[ "umlsterm" ]
thermotolerance is a Phenotype, nitrogen - fixing is a Phenotype, cyanobacterium is a Microorganism, Anabaena sp . strain L-31 is a Microorganism, Escherichia coli is a Microorganism, nitrogen - fixing is a Phenotype, soil is a Habitat, cyanobacterium is a Microorganism, Anabaena sp . strain L-31 is a Microorganism, abilities to survive prolonged and continuous heat stress is a Phenotype, Anabaena sp . strain L-31 is a Microorganism, E. coli is a Microorganism, Nitrogenase activity is a Phenotype, Anabaena is a Microorganism, L-31 is a Microorganism, E. coli is a Microorganism, thermotolerance is a Phenotype
7_task0
Sentence: Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Microorganism, Phenotype, Habitat
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Habitat", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "B-Microorganism", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "O", "O", "O", "O" ]
Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress.
[ "Heat", "-", "shock", "response", "and", "its", "contribution", "to", "thermotolerance", "of", "the", "nitrogen", "-", "fixing", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", ".", "Compared", "to", "Escherichia", "coli", ",", "the", "nitrogen", "-", "fixing", "soil", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", "exhibited", "significantly", "superior", "abilities", "to", "survive", "prolonged", "and", "continuous", "heat", "stress", "and", "recover", "therefrom", ".", "Temperature", "upshift", "induced", "the", "synthesis", "of", "heat", "-", "shock", "proteins", "of", "similar", "molecular", "mass", "in", "the", "two", "microbes", ".", "However", ",", "in", "Anabaena", "sp", ".", "strain", "L-31", "the", "heat", "-", "shock", "proteins", "(", "particularly", "the", "GroEL", "proteins", ")", "were", "synthesised", "throughout", "the", "stress", "period", ",", "were", "much", "more", "stable", "and", "accumulated", "during", "heat", "stress", ".", "In", "contrast", ",", "in", "E.", "coli", "the", "heat", "-", "shock", "proteins", "were", "transiently", "synthesised", ",", "quickly", "turned", "over", "and", "did", "not", "accumulate", ".", "Nitrogenase", "activity", "of", "Anabaena", "cells", "of", "sp", ".", "strain", "L-31", "continuously", "exposed", "to", "heat", "stress", "for", "7", "days", "rapidly", "recovered", "from", "thermal", "injury", ",", "although", "growth", "recovery", "was", "delayed", ".", "Exposure", "of", "E.", "coli", "cells", "to", ">", "4.5", "h", "of", "heat", "stress", "resulted", "in", "a", "complete", "loss", "of", "viability", "and", "the", "ability", "to", "recover", ".", "Marked", "differences", "in", "the", "synthesis", ",", "stability", "and", "accumulation", "of", "heat", "-", "shock", "proteins", "appear", "to", "distinguish", "these", "bacteria", "in", "their", "thermotolerance", "and", "recovery", "from", "heat", "stress", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
thermotolerance is a Phenotype, nitrogen - fixing is a Phenotype, cyanobacterium is a Microorganism, Anabaena sp . strain L-31 is a Microorganism, Escherichia coli is a Microorganism, nitrogen - fixing is a Phenotype, soil is a Habitat, cyanobacterium is a Microorganism, Anabaena sp . strain L-31 is a Microorganism, abilities to survive prolonged and continuous heat stress is a Phenotype, Anabaena sp . strain L-31 is a Microorganism, E. coli is a Microorganism, Nitrogenase activity is a Phenotype, Anabaena is a Microorganism, L-31 is a Microorganism, E. coli is a Microorganism, thermotolerance is a Phenotype
7_task1
Sentence: Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress. Instructions: please typing these entity words according to sentence: thermotolerance, nitrogen - fixing, cyanobacterium, Anabaena sp . strain L-31, Escherichia coli, nitrogen - fixing, soil, cyanobacterium, Anabaena sp . strain L-31, abilities to survive prolonged and continuous heat stress, Anabaena sp . strain L-31, E. coli, Nitrogenase activity, Anabaena, L-31, E. coli, thermotolerance Options: Microorganism, Phenotype, Habitat
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Habitat", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "B-Microorganism", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "O", "O", "O", "O" ]
Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress.
[ "Heat", "-", "shock", "response", "and", "its", "contribution", "to", "thermotolerance", "of", "the", "nitrogen", "-", "fixing", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", ".", "Compared", "to", "Escherichia", "coli", ",", "the", "nitrogen", "-", "fixing", "soil", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", "exhibited", "significantly", "superior", "abilities", "to", "survive", "prolonged", "and", "continuous", "heat", "stress", "and", "recover", "therefrom", ".", "Temperature", "upshift", "induced", "the", "synthesis", "of", "heat", "-", "shock", "proteins", "of", "similar", "molecular", "mass", "in", "the", "two", "microbes", ".", "However", ",", "in", "Anabaena", "sp", ".", "strain", "L-31", "the", "heat", "-", "shock", "proteins", "(", "particularly", "the", "GroEL", "proteins", ")", "were", "synthesised", "throughout", "the", "stress", "period", ",", "were", "much", "more", "stable", "and", "accumulated", "during", "heat", "stress", ".", "In", "contrast", ",", "in", "E.", "coli", "the", "heat", "-", "shock", "proteins", "were", "transiently", "synthesised", ",", "quickly", "turned", "over", "and", "did", "not", "accumulate", ".", "Nitrogenase", "activity", "of", "Anabaena", "cells", "of", "sp", ".", "strain", "L-31", "continuously", "exposed", "to", "heat", "stress", "for", "7", "days", "rapidly", "recovered", "from", "thermal", "injury", ",", "although", "growth", "recovery", "was", "delayed", ".", "Exposure", "of", "E.", "coli", "cells", "to", ">", "4.5", "h", "of", "heat", "stress", "resulted", "in", "a", "complete", "loss", "of", "viability", "and", "the", "ability", "to", "recover", ".", "Marked", "differences", "in", "the", "synthesis", ",", "stability", "and", "accumulation", "of", "heat", "-", "shock", "proteins", "appear", "to", "distinguish", "these", "bacteria", "in", "their", "thermotolerance", "and", "recovery", "from", "heat", "stress", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
thermotolerance, nitrogen - fixing, cyanobacterium, Anabaena sp . strain L-31, Escherichia coli, nitrogen - fixing, soil, cyanobacterium, Anabaena sp . strain L-31, abilities to survive prolonged and continuous heat stress, Anabaena sp . strain L-31, E. coli, Nitrogenase activity, Anabaena, L-31, E. coli, thermotolerance
7_task2
Sentence: Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "B-Habitat", "B-Microorganism", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "B-Microorganism", "O", "O", "O", "O", "O", "B-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "O", "O", "O", "O" ]
Heat-shock response and its contribution to thermotolerance of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31. Compared to Escherichia coli, the nitrogen-fixing soil cyanobacterium Anabaena sp. strain L-31 exhibited significantly superior abilities to survive prolonged and continuous heat stress and recover therefrom. Temperature upshift induced the synthesis of heat-shock proteins of similar molecular mass in the two microbes. However, in Anabaena sp. strain L-31 the heat-shock proteins (particularly the GroEL proteins) were synthesised throughout the stress period, were much more stable and accumulated during heat stress. In contrast, in E. coli the heat-shock proteins were transiently synthesised, quickly turned over and did not accumulate. Nitrogenase activity of Anabaena cells of sp. strain L-31 continuously exposed to heat stress for 7 days rapidly recovered from thermal injury, although growth recovery was delayed. Exposure of E. coli cells to >4.5 h of heat stress resulted in a complete loss of viability and the ability to recover. Marked differences in the synthesis, stability and accumulation of heat-shock proteins appear to distinguish these bacteria in their thermotolerance and recovery from heat stress.
[ "Heat", "-", "shock", "response", "and", "its", "contribution", "to", "thermotolerance", "of", "the", "nitrogen", "-", "fixing", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", ".", "Compared", "to", "Escherichia", "coli", ",", "the", "nitrogen", "-", "fixing", "soil", "cyanobacterium", "Anabaena", "sp", ".", "strain", "L-31", "exhibited", "significantly", "superior", "abilities", "to", "survive", "prolonged", "and", "continuous", "heat", "stress", "and", "recover", "therefrom", ".", "Temperature", "upshift", "induced", "the", "synthesis", "of", "heat", "-", "shock", "proteins", "of", "similar", "molecular", "mass", "in", "the", "two", "microbes", ".", "However", ",", "in", "Anabaena", "sp", ".", "strain", "L-31", "the", "heat", "-", "shock", "proteins", "(", "particularly", "the", "GroEL", "proteins", ")", "were", "synthesised", "throughout", "the", "stress", "period", ",", "were", "much", "more", "stable", "and", "accumulated", "during", "heat", "stress", ".", "In", "contrast", ",", "in", "E.", "coli", "the", "heat", "-", "shock", "proteins", "were", "transiently", "synthesised", ",", "quickly", "turned", "over", "and", "did", "not", "accumulate", ".", "Nitrogenase", "activity", "of", "Anabaena", "cells", "of", "sp", ".", "strain", "L-31", "continuously", "exposed", "to", "heat", "stress", "for", "7", "days", "rapidly", "recovered", "from", "thermal", "injury", ",", "although", "growth", "recovery", "was", "delayed", ".", "Exposure", "of", "E.", "coli", "cells", "to", ">", "4.5", "h", "of", "heat", "stress", "resulted", "in", "a", "complete", "loss", "of", "viability", "and", "the", "ability", "to", "recover", ".", "Marked", "differences", "in", "the", "synthesis", ",", "stability", "and", "accumulation", "of", "heat", "-", "shock", "proteins", "appear", "to", "distinguish", "these", "bacteria", "in", "their", "thermotolerance", "and", "recovery", "from", "heat", "stress", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
mAb is a reagent, FA - A is a cell, mAb is a reagent, HeLa is a cell
1.0alpha7.train.1308_task0
Sentence: At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: reagent, cell
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "O", "O", "O", "O", "O", "O", "O" ]
At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ).
[ "At", "all", "concentrations", "tested", ",", "reduced", "binding", "of", "the", " ", "mAb", "to", "the", " ", "230", "kDa", "protein", "from", " ", "FA", "-", "A", "cells", "was", "observed", "compared", "with", " ", "mAb", "binding", "to", " ", "this", "protein", "from", "normal", "or", "HeLa", "cells", "(", "Figure", "5B", " ", ")", "." ]
[ "cell", "reagent" ]
mAb is a reagent, FA - A is a cell, mAb is a reagent, HeLa is a cell
1.0alpha7.train.1308_task1
Sentence: At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ). Instructions: please typing these entity words according to sentence: mAb, FA - A, mAb, HeLa Options: reagent, cell
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "O", "O", "O", "O", "O", "O", "O" ]
At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ).
[ "At", "all", "concentrations", "tested", ",", "reduced", "binding", "of", "the", " ", "mAb", "to", "the", " ", "230", "kDa", "protein", "from", " ", "FA", "-", "A", "cells", "was", "observed", "compared", "with", " ", "mAb", "binding", "to", " ", "this", "protein", "from", "normal", "or", "HeLa", "cells", "(", "Figure", "5B", " ", ")", "." ]
[ "cell", "reagent" ]
mAb, FA - A, mAb, HeLa
1.0alpha7.train.1308_task2
Sentence: At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ). Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "O", "O", "O", "O", "O", "O", "B-reagent", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "O", "O", "O", "O", "O", "O", "O" ]
At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B ).
[ "At", "all", "concentrations", "tested", ",", "reduced", "binding", "of", "the", " ", "mAb", "to", "the", " ", "230", "kDa", "protein", "from", " ", "FA", "-", "A", "cells", "was", "observed", "compared", "with", " ", "mAb", "binding", "to", " ", "this", "protein", "from", "normal", "or", "HeLa", "cells", "(", "Figure", "5B", " ", ")", "." ]
[ "cell", "reagent" ]