bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
laminin is a Individual_protein, myosin heavy chain is a Individual_protein, MHC is a Individual_protein, alpha - skeletal actin is a Individual_protein	702_task1	Sentence: The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture. Instructions: please typing these entity words according to sentence: laminin, myosin heavy chain, MHC, alpha - skeletal actin Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture.	[ "The", "effects", "of", "two", "adhesion", "substrates", "(", "serum", "and", "laminin", ")", "and", "time", "in", "culture", "on", "the", "expression", "of", "genes", "encoding", "myosin", "heavy", "chain", "(", "MHC", ")", "isoforms", "and", "alpha", "-", "skeletal", "actin", "were", "analysed", "in", "myocytes", "isolated", "from", "adult", "rat", "heart", "and", "maintained", "in", "serum", "-", "free", "culture", "." ]	[ "Individual_protein" ]
laminin, myosin heavy chain, MHC, alpha - skeletal actin	702_task2	Sentence: The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture.	[ "The", "effects", "of", "two", "adhesion", "substrates", "(", "serum", "and", "laminin", ")", "and", "time", "in", "culture", "on", "the", "expression", "of", "genes", "encoding", "myosin", "heavy", "chain", "(", "MHC", ")", "isoforms", "and", "alpha", "-", "skeletal", "actin", "were", "analysed", "in", "myocytes", "isolated", "from", "adult", "rat", "heart", "and", "maintained", "in", "serum", "-", "free", "culture", "." ]	[ "Individual_protein" ]
skull is an umlsterm, titanium is an umlsterm, bone replacement material is an umlsterm, tissue is an umlsterm, surgical is an umlsterm, technique is an umlsterm, patient is an umlsterm, transfer is an umlsterm, evaluation is an umlsterm, postoperative is an umlsterm, use is an umlsterm, techniques is an umlsterm, implants is an umlsterm, laws is an umlsterm, documentation is an umlsterm, computer - based is an umlsterm, skull is an umlsterm, procedure is an umlsterm, titanium is an umlsterm, technique is an umlsterm, elements is an umlsterm, defects is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, patients is an umlsterm, hospital is an umlsterm, postoperative is an umlsterm, MRI is an umlsterm, documentation is an umlsterm, control is an umlsterm, documentation is an umlsterm, techniques is an umlsterm, bone is an umlsterm, Hand is an umlsterm, hand is an umlsterm, research is an umlsterm, criteria is an umlsterm, techniques is an umlsterm, determination is an umlsterm, MRI is an umlsterm, magnetic is an umlsterm, titanium is an umlsterm, postoperative is an umlsterm, documentation is an umlsterm, tumor is an umlsterm, surgery is an umlsterm	MundKieferGesichtschirurgie.0004s504.eng.abstr_task0	Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .	[ "Computer", "-", "assisted", "prefabricated", "skull", "implants", "of", "pure", "titanium", "as", "a", "bone", "replacement", "material", "have", "been", "used", "in", "22", "departments", "since", "1994", ".", "Our", "experience", "with", "104", "implants", "includes", "clinical", "aspects", "(", "indication", ";", "tissue", "quality", ";", "surgical", "technique", ";", "patient", "guidance", ")", ",", "but", "also", "geometric", "and", "material", "-", "specific", "parameters", "(", "acquisition", ",", "transfer", ",", "and", "evaluation", "of", "CT", "data", ";", "construction", ";", "manufacturing", ";", "cleaning", ";", "postoperative", "use", "of", "radiologic", "techniques", ")", ".", "While", "the", "clinical", "aspects", "are", "responsibly", "defined", "by", "the", "respective", "surgeon", ",", "the", "geometric", "and", "material", "-", "specific", "parameters", "of", "individual", "implants", "have", "to", "comply", "with", "the", "laws", "on", "medical", "products", ".", "Therefore", ",", "the", "prospective", "documentation", "for", "each", "implant", "includes", ":", "helical", "CT", "acquisition", "parameters", ";", "geometric", "data", "of", "the", "computer", "-", "based", "skull", "model", "and", "implant", ";", "the", "cleaning", "procedure", ";", "and", "the", "individual", "marking", ".", "Medically", "specified", "pure", "titanium", "is", "processed", "by", "milling", "only", "so", "that", "neither", "purity", "nor", "structure", "is", "impaired", ".", "A", "specially", "developed", "milling", "technique", "guarantees", "the", "fabrication", "of", "all", "constructed", "elements", "down", "to", "fine", "details", "of", "50", "µm", ".", "Considering", "the", "necessary", "radiologic", "follow", "-", "up", "of", "defects", "after", "tumor", "surgery", ",", "all", "patients", "in", "our", "hospital", "undergo", "postoperative", "MRI", "examination", ",", "partly", "with", "preoperative", "documentation", "as", "an", "intraindividual", "control", ".", "Such", "comprehensive", "documentation", "and", "quality", "assurance", "is", "essential", "for", "techniques", "of", "prefabricated", "bone", "substitution", ".", "Hand", "in", "hand", "with", "scientific", "research", "and", "clinical", "application", ",", "these", "formal", "criteria", "have", "to", "be", "elaborated", "and", "fulfilled", "for", "the", "respective", "techniques", ".", "The", "successful", "determination", "of", "specifically", "adapted", "MRI", "sequences", "goes", "even", "one", "step", "further", ":", "spin", "-", "echo", "sequences", "minimize", "inhomogeneities", "of", "the", "magnetic", "field", "induced", "by", "the", "titanium", "implants", "and", "enable", "accurate", "postoperative", "documentation", "and", "diagnostics", "especially", "in", "the", "follow", "-", "up", "after", "tumor", "surgery", "." ]	[ "umlsterm" ]
skull is an umlsterm, titanium is an umlsterm, bone replacement material is an umlsterm, tissue is an umlsterm, surgical is an umlsterm, technique is an umlsterm, patient is an umlsterm, transfer is an umlsterm, evaluation is an umlsterm, postoperative is an umlsterm, use is an umlsterm, techniques is an umlsterm, implants is an umlsterm, laws is an umlsterm, documentation is an umlsterm, computer - based is an umlsterm, skull is an umlsterm, procedure is an umlsterm, titanium is an umlsterm, technique is an umlsterm, elements is an umlsterm, defects is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, patients is an umlsterm, hospital is an umlsterm, postoperative is an umlsterm, MRI is an umlsterm, documentation is an umlsterm, control is an umlsterm, documentation is an umlsterm, techniques is an umlsterm, bone is an umlsterm, Hand is an umlsterm, hand is an umlsterm, research is an umlsterm, criteria is an umlsterm, techniques is an umlsterm, determination is an umlsterm, MRI is an umlsterm, magnetic is an umlsterm, titanium is an umlsterm, postoperative is an umlsterm, documentation is an umlsterm, tumor is an umlsterm, surgery is an umlsterm	MundKieferGesichtschirurgie.0004s504.eng.abstr_task1	Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please typing these entity words according to sentence: skull, titanium, bone replacement material, tissue, surgical, technique, patient, transfer, evaluation, postoperative, use, techniques, implants, laws, documentation, computer - based, skull, procedure, titanium, technique, elements, defects, tumor, surgery, patients, hospital, postoperative, MRI, documentation, control, documentation, techniques, bone, Hand, hand, research, criteria, techniques, determination, MRI, magnetic, titanium, postoperative, documentation, tumor, surgery Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .	[ "Computer", "-", "assisted", "prefabricated", "skull", "implants", "of", "pure", "titanium", "as", "a", "bone", "replacement", "material", "have", "been", "used", "in", "22", "departments", "since", "1994", ".", "Our", "experience", "with", "104", "implants", "includes", "clinical", "aspects", "(", "indication", ";", "tissue", "quality", ";", "surgical", "technique", ";", "patient", "guidance", ")", ",", "but", "also", "geometric", "and", "material", "-", "specific", "parameters", "(", "acquisition", ",", "transfer", ",", "and", "evaluation", "of", "CT", "data", ";", "construction", ";", "manufacturing", ";", "cleaning", ";", "postoperative", "use", "of", "radiologic", "techniques", ")", ".", "While", "the", "clinical", "aspects", "are", "responsibly", "defined", "by", "the", "respective", "surgeon", ",", "the", "geometric", "and", "material", "-", "specific", "parameters", "of", "individual", "implants", "have", "to", "comply", "with", "the", "laws", "on", "medical", "products", ".", "Therefore", ",", "the", "prospective", "documentation", "for", "each", "implant", "includes", ":", "helical", "CT", "acquisition", "parameters", ";", "geometric", "data", "of", "the", "computer", "-", "based", "skull", "model", "and", "implant", ";", "the", "cleaning", "procedure", ";", "and", "the", "individual", "marking", ".", "Medically", "specified", "pure", "titanium", "is", "processed", "by", "milling", "only", "so", "that", "neither", "purity", "nor", "structure", "is", "impaired", ".", "A", "specially", "developed", "milling", "technique", "guarantees", "the", "fabrication", "of", "all", "constructed", "elements", "down", "to", "fine", "details", "of", "50", "µm", ".", "Considering", "the", "necessary", "radiologic", "follow", "-", "up", "of", "defects", "after", "tumor", "surgery", ",", "all", "patients", "in", "our", "hospital", "undergo", "postoperative", "MRI", "examination", ",", "partly", "with", "preoperative", "documentation", "as", "an", "intraindividual", "control", ".", "Such", "comprehensive", "documentation", "and", "quality", "assurance", "is", "essential", "for", "techniques", "of", "prefabricated", "bone", "substitution", ".", "Hand", "in", "hand", "with", "scientific", "research", "and", "clinical", "application", ",", "these", "formal", "criteria", "have", "to", "be", "elaborated", "and", "fulfilled", "for", "the", "respective", "techniques", ".", "The", "successful", "determination", "of", "specifically", "adapted", "MRI", "sequences", "goes", "even", "one", "step", "further", ":", "spin", "-", "echo", "sequences", "minimize", "inhomogeneities", "of", "the", "magnetic", "field", "induced", "by", "the", "titanium", "implants", "and", "enable", "accurate", "postoperative", "documentation", "and", "diagnostics", "especially", "in", "the", "follow", "-", "up", "after", "tumor", "surgery", "." ]	[ "umlsterm" ]
skull, titanium, bone replacement material, tissue, surgical, technique, patient, transfer, evaluation, postoperative, use, techniques, implants, laws, documentation, computer - based, skull, procedure, titanium, technique, elements, defects, tumor, surgery, patients, hospital, postoperative, MRI, documentation, control, documentation, techniques, bone, Hand, hand, research, criteria, techniques, determination, MRI, magnetic, titanium, postoperative, documentation, tumor, surgery	MundKieferGesichtschirurgie.0004s504.eng.abstr_task2	Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .	[ "Computer", "-", "assisted", "prefabricated", "skull", "implants", "of", "pure", "titanium", "as", "a", "bone", "replacement", "material", "have", "been", "used", "in", "22", "departments", "since", "1994", ".", "Our", "experience", "with", "104", "implants", "includes", "clinical", "aspects", "(", "indication", ";", "tissue", "quality", ";", "surgical", "technique", ";", "patient", "guidance", ")", ",", "but", "also", "geometric", "and", "material", "-", "specific", "parameters", "(", "acquisition", ",", "transfer", ",", "and", "evaluation", "of", "CT", "data", ";", "construction", ";", "manufacturing", ";", "cleaning", ";", "postoperative", "use", "of", "radiologic", "techniques", ")", ".", "While", "the", "clinical", "aspects", "are", "responsibly", "defined", "by", "the", "respective", "surgeon", ",", "the", "geometric", "and", "material", "-", "specific", "parameters", "of", "individual", "implants", "have", "to", "comply", "with", "the", "laws", "on", "medical", "products", ".", "Therefore", ",", "the", "prospective", "documentation", "for", "each", "implant", "includes", ":", "helical", "CT", "acquisition", "parameters", ";", "geometric", "data", "of", "the", "computer", "-", "based", "skull", "model", "and", "implant", ";", "the", "cleaning", "procedure", ";", "and", "the", "individual", "marking", ".", "Medically", "specified", "pure", "titanium", "is", "processed", "by", "milling", "only", "so", "that", "neither", "purity", "nor", "structure", "is", "impaired", ".", "A", "specially", "developed", "milling", "technique", "guarantees", "the", "fabrication", "of", "all", "constructed", "elements", "down", "to", "fine", "details", "of", "50", "µm", ".", "Considering", "the", "necessary", "radiologic", "follow", "-", "up", "of", "defects", "after", "tumor", "surgery", ",", "all", "patients", "in", "our", "hospital", "undergo", "postoperative", "MRI", "examination", ",", "partly", "with", "preoperative", "documentation", "as", "an", "intraindividual", "control", ".", "Such", "comprehensive", "documentation", "and", "quality", "assurance", "is", "essential", "for", "techniques", "of", "prefabricated", "bone", "substitution", ".", "Hand", "in", "hand", "with", "scientific", "research", "and", "clinical", "application", ",", "these", "formal", "criteria", "have", "to", "be", "elaborated", "and", "fulfilled", "for", "the", "respective", "techniques", ".", "The", "successful", "determination", "of", "specifically", "adapted", "MRI", "sequences", "goes", "even", "one", "step", "further", ":", "spin", "-", "echo", "sequences", "minimize", "inhomogeneities", "of", "the", "magnetic", "field", "induced", "by", "the", "titanium", "implants", "and", "enable", "accurate", "postoperative", "documentation", "and", "diagnostics", "especially", "in", "the", "follow", "-", "up", "after", "tumor", "surgery", "." ]	[ "umlsterm" ]
myosin heavy chain is a Individual_protein, MHC is a Individual_protein, actin is a Gene/protein/RNA	758_task0	Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.	[ "The", "primary", "purpose", "of", "this", "study", "was", "to", "determine", "the", "relationship", "between", "myosin", "heavy", "chain", "(", "MHC", ")", "and", "actin", "contents", "and", "maximum", "isometric", "tetanic", "force", "(", "Po", ")", "in", "mouse", "extensor", "digitorum", "longus", "(", "EDL", ")", "muscles", "following", "eccentric", "contraction", "-", "induced", "injury", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
myosin heavy chain is a Individual_protein, MHC is a Individual_protein, actin is a Gene/protein/RNA	758_task1	Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please typing these entity words according to sentence: myosin heavy chain, MHC, actin Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.	[ "The", "primary", "purpose", "of", "this", "study", "was", "to", "determine", "the", "relationship", "between", "myosin", "heavy", "chain", "(", "MHC", ")", "and", "actin", "contents", "and", "maximum", "isometric", "tetanic", "force", "(", "Po", ")", "in", "mouse", "extensor", "digitorum", "longus", "(", "EDL", ")", "muscles", "following", "eccentric", "contraction", "-", "induced", "injury", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
myosin heavy chain, MHC, actin	758_task2	Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.	[ "The", "primary", "purpose", "of", "this", "study", "was", "to", "determine", "the", "relationship", "between", "myosin", "heavy", "chain", "(", "MHC", ")", "and", "actin", "contents", "and", "maximum", "isometric", "tetanic", "force", "(", "Po", ")", "in", "mouse", "extensor", "digitorum", "longus", "(", "EDL", ")", "muscles", "following", "eccentric", "contraction", "-", "induced", "injury", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
both sexes is a Person, from 18 years is a Value, community - acquired pneumonia is a Condition, COPD is a Condition, Bronchial Asthma is a Condition, community - acquired pneumonia is a Condition, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 % is a Scope, COPD is a Condition, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction is a Scope	NCT02787863_inc_task0	Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Person, Condition, Value	[ "O", "O", "B-Person", "I-Person", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.	[ "Individuals", "of", "both", "sexes", "from", "18", "years", "with", "a", "diagnosis", "of", "community", "-", "acquired", "pneumonia", ",", "COPD", "or", "Bronchial", "Asthma", ";", "\n", "The", "presence", "of", "signed", "and", "dated", "informed", "consent", "to", "participate", "in", "a", "clinical", "study", ";", "\n", "The", "ability", "to", "perform", "the", "requirements", "of", "the", "Protocol", ";", "\n", "For", "women", "of", "childbearing", "age", "is", "a", "negative", "result", "of", "a", "pregnancy", "test", "before", "vaccination", ".", "\n", "community", "-", "acquired", "pneumonia", ":", "the", "presence", "of", "radiologically", "confirmed", "infiltration", "of", "the", "lung", "tissue", ";", "the", "presence", "of", "at", "least", "two", "of", "the", "following", "clinical", "signs", ":", "acute", "fever", "early", "in", "the", "disease", "(", "temperature", ">", "38.0", "°", "C", ")", ",", "cough", "with", "sputum", ",", "the", "physical", "signs", "of", "pneumonia", "(", "focus", "of", "crepitate", "and", "/", "or", "fine", "bubble", "rales", ",", "bronchial", "breathing", "hard", ",", "shortening", "of", "percussion", "sounds", ")", ",", "leukocytosis", ">", "10", "*", "10", "9", "/l", "and", "/", "or", "stab", "shift", ">", "10", "%", ";", "the", "occurrence", "of", "the", "disease", "outside", "the", "hospital", "and", "the", "organized", "groups", "(", "such", "as", "nursing", "homes", ",", "sanatoriums", ",", "etc", ".", ")", ".", "\n", "COPD", ":", "dyspnea", ":", "progressive", "(", "worsens", "over", "time", ")", ",", "increases", "with", "exertion", ",", "persistent", ";", "chronic", "cough", "(", "may", "appear", "sporadically", "and", "may", "be", "unproductive", ")", ";", "chronic", "expectoration", ";", "the", "impact", "of", "risk", "factors", "in", "the", "medical", "history", "(", "Smoking", ",", "occupational", "dust", "pollutants", "and", "chemicals", ")", ";", "widespread", "wheeze", "on", "auscultation", "of", "the", "chest", "and", "/", "or", "distant", "wheezing", "in", "the", "chest", ";", "family", "history", "of", "COPD", ";", "spirometric", "data", "confirming", "the", "presence", "of", "fixed", "bronchial", "obstruction", ".", "\n" ]	[ "Scope", "Condition", "Qualifier", "Temporal", "Procedure", "Observation", "Value", "Person", "Multiplier", "Measurement" ]
both sexes is a Person, from 18 years is a Value, community - acquired pneumonia is a Condition, COPD is a Condition, Bronchial Asthma is a Condition, community - acquired pneumonia is a Condition, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 % is a Scope, COPD is a Condition, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction is a Scope	NCT02787863_inc_task1	Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 1010 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please typing these entity words according to sentence: both sexes, from 18 years, community - acquired pneumonia, COPD, Bronchial Asthma, community - acquired pneumonia, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 10 9 /l and / or stab shift > 10 %, COPD, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction Options: Scope, Person, Condition, Value	[ "O", "O", "B-Person", "I-Person", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.	[ "Individuals", "of", "both", "sexes", "from", "18", "years", "with", "a", "diagnosis", "of", "community", "-", "acquired", "pneumonia", ",", "COPD", "or", "Bronchial", "Asthma", ";", "\n", "The", "presence", "of", "signed", "and", "dated", "informed", "consent", "to", "participate", "in", "a", "clinical", "study", ";", "\n", "The", "ability", "to", "perform", "the", "requirements", "of", "the", "Protocol", ";", "\n", "For", "women", "of", "childbearing", "age", "is", "a", "negative", "result", "of", "a", "pregnancy", "test", "before", "vaccination", ".", "\n", "community", "-", "acquired", "pneumonia", ":", "the", "presence", "of", "radiologically", "confirmed", "infiltration", "of", "the", "lung", "tissue", ";", "the", "presence", "of", "at", "least", "two", "of", "the", "following", "clinical", "signs", ":", "acute", "fever", "early", "in", "the", "disease", "(", "temperature", ">", "38.0", "°", "C", ")", ",", "cough", "with", "sputum", ",", "the", "physical", "signs", "of", "pneumonia", "(", "focus", "of", "crepitate", "and", "/", "or", "fine", "bubble", "rales", ",", "bronchial", "breathing", "hard", ",", "shortening", "of", "percussion", "sounds", ")", ",", "leukocytosis", ">", "10", "*", "10", "9", "/l", "and", "/", "or", "stab", "shift", ">", "10", "%", ";", "the", "occurrence", "of", "the", "disease", "outside", "the", "hospital", "and", "the", "organized", "groups", "(", "such", "as", "nursing", "homes", ",", "sanatoriums", ",", "etc", ".", ")", ".", "\n", "COPD", ":", "dyspnea", ":", "progressive", "(", "worsens", "over", "time", ")", ",", "increases", "with", "exertion", ",", "persistent", ";", "chronic", "cough", "(", "may", "appear", "sporadically", "and", "may", "be", "unproductive", ")", ";", "chronic", "expectoration", ";", "the", "impact", "of", "risk", "factors", "in", "the", "medical", "history", "(", "Smoking", ",", "occupational", "dust", "pollutants", "and", "chemicals", ")", ";", "widespread", "wheeze", "on", "auscultation", "of", "the", "chest", "and", "/", "or", "distant", "wheezing", "in", "the", "chest", ";", "family", "history", "of", "COPD", ";", "spirometric", "data", "confirming", "the", "presence", "of", "fixed", "bronchial", "obstruction", ".", "\n" ]	[ "Scope", "Condition", "Qualifier", "Temporal", "Procedure", "Observation", "Value", "Person", "Multiplier", "Measurement" ]
both sexes, from 18 years, community - acquired pneumonia, COPD, Bronchial Asthma, community - acquired pneumonia, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 %, COPD, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction	NCT02787863_inc_task2	Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Person", "I-Person", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.	[ "Individuals", "of", "both", "sexes", "from", "18", "years", "with", "a", "diagnosis", "of", "community", "-", "acquired", "pneumonia", ",", "COPD", "or", "Bronchial", "Asthma", ";", "\n", "The", "presence", "of", "signed", "and", "dated", "informed", "consent", "to", "participate", "in", "a", "clinical", "study", ";", "\n", "The", "ability", "to", "perform", "the", "requirements", "of", "the", "Protocol", ";", "\n", "For", "women", "of", "childbearing", "age", "is", "a", "negative", "result", "of", "a", "pregnancy", "test", "before", "vaccination", ".", "\n", "community", "-", "acquired", "pneumonia", ":", "the", "presence", "of", "radiologically", "confirmed", "infiltration", "of", "the", "lung", "tissue", ";", "the", "presence", "of", "at", "least", "two", "of", "the", "following", "clinical", "signs", ":", "acute", "fever", "early", "in", "the", "disease", "(", "temperature", ">", "38.0", "°", "C", ")", ",", "cough", "with", "sputum", ",", "the", "physical", "signs", "of", "pneumonia", "(", "focus", "of", "crepitate", "and", "/", "or", "fine", "bubble", "rales", ",", "bronchial", "breathing", "hard", ",", "shortening", "of", "percussion", "sounds", ")", ",", "leukocytosis", ">", "10", "*", "10", "9", "/l", "and", "/", "or", "stab", "shift", ">", "10", "%", ";", "the", "occurrence", "of", "the", "disease", "outside", "the", "hospital", "and", "the", "organized", "groups", "(", "such", "as", "nursing", "homes", ",", "sanatoriums", ",", "etc", ".", ")", ".", "\n", "COPD", ":", "dyspnea", ":", "progressive", "(", "worsens", "over", "time", ")", ",", "increases", "with", "exertion", ",", "persistent", ";", "chronic", "cough", "(", "may", "appear", "sporadically", "and", "may", "be", "unproductive", ")", ";", "chronic", "expectoration", ";", "the", "impact", "of", "risk", "factors", "in", "the", "medical", "history", "(", "Smoking", ",", "occupational", "dust", "pollutants", "and", "chemicals", ")", ";", "widespread", "wheeze", "on", "auscultation", "of", "the", "chest", "and", "/", "or", "distant", "wheezing", "in", "the", "chest", ";", "family", "history", "of", "COPD", ";", "spirometric", "data", "confirming", "the", "presence", "of", "fixed", "bronchial", "obstruction", ".", "\n" ]	[ "Scope", "Condition", "Qualifier", "Temporal", "Procedure", "Observation", "Value", "Person", "Multiplier", "Measurement" ]
gadolinio is a NORMALIZABLES	450_task0	Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.	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gadolinio is a NORMALIZABLES	450_task1	Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. 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Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.	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gadolinio	450_task2	Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. 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Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.	[ "Niño", "de", "cinco", "años", "derivado", "por", "su", "pediatra", "de", "Atención", "Primaria", "para", "estudio", "por", "deformidad", "craneal", "frontoparietotemporal", "derecha", "que", "se", "había", "hecho", "más", "evidente", "en", "los", "últimos", "meses", ".", "Había", "presentado", "vómitos", "ocasionales", "con", "los", "malos", "olores", ",", "de", "un", "año", "de", "evolución", ",", "y", "cefalea", "acompañada", "de", "sonofobia", "y", "fonofobia", ",", "de", "frecuencia", "variable", "e", "intensidad", "leve", "que", "nunca", "le", "había", "despertado", "por", "la", "noche", "desde", "los", "tres", "años", "y", "medio", ".", "La", "exploración", "neurológica", "fue", "normal", "(", "incluido", "el", "fondo", "de", "ojo", ")", ",", "excepto", "la", "macrocefalia", "con", "55", "cm", "de", "perímetro", "cefálico", "(", ">", "percentil", "99", ")", ".", "\n", "El", "único", "antecedente", "familiar", "significativo", "es", "un", "QA", "frontal", "izquierdo", "intervenido", "en", "el", "abuelo", "paterno", ".", "\n", "Nacido", "de", "embarazo", "controlado", ",", "con", "ecografías", "prenatales", "normales", "y", "parto", "eutócico", "sin", "complicaciones", ".", "No", "tenía", "otros", "antecedentes", "personales", "de", "interés", ".", "El", "desarrollo", "psicomotor", "fue", "normal", ",", "con", "marcha", "libre", "a", "los", "13", "meses", ",", "lenguaje", "y", "sociabilidad", "adecuada", "a", "la", "edad", ",", "y", "está", "escolarizado", "con", "dificultades", "de", "aprendizaje", "de", "la", "lectoescritura", ".", "\n", "En", "la", "TC", "cranealse", "visualiza", "un", "QA", "de", "gran", "tamaño", "en", "la", "fosa", "craneal", "media", "derecha", "con", "desplazamiento", "de", "la", "línea", "media", "y", "colapso", "de", "las", "astas", "ventriculares", "adyacentes", ",", "que", "se", "confirma", "en", "RM", "craneal", "mostrando", "en", "la", "región", "frontoparietotemporal", "derecha", "un", "contenido", "hipointenso", "en", "secuencias", "de", "T1", "e", "hiperintensas", "en", "T2", ";", "que", "no", "se", "modifica", "tras", "el", "contraste", "con", "gadolinio", ".", "\n\n", "Se", "deriva", "a", "Neurocirugía", ",", "donde", "se", "monitorizan", "las", "presiones", "intracraneales", "con", "un", "sensor", "epidural", "neumático", ",", "mediante", "trépano", "frontal", "precoronal", ",", "encontrando", "patológicas", "solo", "las", "nocturnas", ".", "Ante", "una", "hipertensión", "intracraneal", "crónica", ",", "se", "decide", "tratamiento", "con", "cistocisternostomía", ",", "comunicando", "el", "QA", "con", "la", "cisterna", "óptico", "-", "carotídea", ",", "mediante", "endoscopio", "angulado", "30", "°", "y", "un", "catéter", "con", "doble", "balón", "de", "ventriculostomía", ",", "para", "favorecer", "la", "comunicación", "de", "los", "espacios", "y", "la", "circulación", "libre", "del", "LCR", ".", "\n\n" ]	[ "NORMALIZABLES" ]
prostanoids is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, pulmonary circulation is an umlsterm, use is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, lung transplantation is an umlsterm, patients is an umlsterm, adult is an umlsterm, respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, vascular resistance is an umlsterm, pressure is an umlsterm, gas is an umlsterm, PGI2 is an umlsterm, aerosol is an umlsterm, vasodilator is an umlsterm, nitric oxide is an umlsterm, aerosol is an umlsterm, PGI2 is an umlsterm, iloprost is an umlsterm, long - term treatment is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, pulmonary hypertension is an umlsterm	IntensiveMedizin.70340370.eng.abstr_task0	Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .	[ "The", "vasodilatory", "prostanoids", "PGE1", "and", "PGI2", "possess", "strong", "vasodilatory", "potency", "in", "the", "pulmonary", "circulation", ".", "Their", "application", "is", ",", "however", ",", "limited", "by", "the", "lack", "of", "pulmonary", "and", "intrapulmonary", "selectivity", ".", "By", "use", "of", "chronic", "ambulatory", "PGI2-infusion", ",", "patients", "with", "primary", "pulmonary", "hypertension", "(", "PPH", ")", "may", "be", "bridged", "for", "(", "heart-", ")", "lung", "transplantation", ".", "In", "patients", "with", "adult", "respiratory", "distress", "syndrome", "(", "ARDS", ")", ",", "PGE1", "and", "PGI2", "lower", "the", "pulmonary", "vascular", "resistance", ",", "but", "may", "also", "decrease", "the", "systemic", "pressure", "(", "limited", "pulmonary", "selectivity", ")", "and", "increase", "ventilation", "-", "perfusion", "-", "mismatch", ",", "accompanied", "by", "an", "impairment", "of", "gas", "exchange", "(", "limited", "intrapulmonary", "selectivity", ")", ".", "Application", "of", "PGI2", "via", "the", "transbronchial", "route", "(", "aerosol", ")", "may", "achieve", "pulmonary", "and", "intrapulmonary", "selectivity", "with", "an", "efficacy", "profile", "comparable", "to", "that", "of", "the", "selective", "pulmonary", "vasodilator", "nitric", "oxide", "(", "NO", ")", ".", "Repetitive", "aerosol", "application", "of", "the", "stable", "PGI2", "analogue", "iloprost", "is", "under", "consideration", "for", "long", "-", "term", "treatment", "of", "patients", "with", "severe", "pulmonary", "hypertension", "such", "as", "primary", "pulmonary", "hypertension", "." ]	[ "umlsterm" ]
prostanoids is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, pulmonary circulation is an umlsterm, use is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, lung transplantation is an umlsterm, patients is an umlsterm, adult is an umlsterm, respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, vascular resistance is an umlsterm, pressure is an umlsterm, gas is an umlsterm, PGI2 is an umlsterm, aerosol is an umlsterm, vasodilator is an umlsterm, nitric oxide is an umlsterm, aerosol is an umlsterm, PGI2 is an umlsterm, iloprost is an umlsterm, long - term treatment is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, pulmonary hypertension is an umlsterm	IntensiveMedizin.70340370.eng.abstr_task1	Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please typing these entity words according to sentence: prostanoids, PGE1, PGI2, pulmonary circulation, use, patients, pulmonary hypertension, lung transplantation, patients, adult, respiratory distress syndrome, ARDS, PGE1, PGI2, vascular resistance, pressure, gas, PGI2, aerosol, vasodilator, nitric oxide, aerosol, PGI2, iloprost, long - term treatment, patients, pulmonary hypertension, pulmonary hypertension Options: umlsterm	[ "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .	[ "The", "vasodilatory", "prostanoids", "PGE1", "and", "PGI2", "possess", "strong", "vasodilatory", "potency", "in", "the", "pulmonary", "circulation", ".", "Their", "application", "is", ",", "however", ",", "limited", "by", "the", "lack", "of", "pulmonary", "and", "intrapulmonary", "selectivity", ".", "By", "use", "of", "chronic", "ambulatory", "PGI2-infusion", ",", "patients", "with", "primary", "pulmonary", "hypertension", "(", "PPH", ")", "may", "be", "bridged", "for", "(", "heart-", ")", "lung", "transplantation", ".", "In", "patients", "with", "adult", "respiratory", "distress", "syndrome", "(", "ARDS", ")", ",", "PGE1", "and", "PGI2", "lower", "the", "pulmonary", "vascular", "resistance", ",", "but", "may", "also", "decrease", "the", "systemic", "pressure", "(", "limited", "pulmonary", "selectivity", ")", "and", "increase", "ventilation", "-", "perfusion", "-", "mismatch", ",", "accompanied", "by", "an", "impairment", "of", "gas", "exchange", "(", "limited", "intrapulmonary", "selectivity", ")", ".", "Application", "of", "PGI2", "via", "the", "transbronchial", "route", "(", "aerosol", ")", "may", "achieve", "pulmonary", "and", "intrapulmonary", "selectivity", "with", "an", "efficacy", "profile", "comparable", "to", "that", "of", "the", "selective", "pulmonary", "vasodilator", "nitric", "oxide", "(", "NO", ")", ".", "Repetitive", "aerosol", "application", "of", "the", "stable", "PGI2", "analogue", "iloprost", "is", "under", "consideration", "for", "long", "-", "term", "treatment", "of", "patients", "with", "severe", "pulmonary", "hypertension", "such", "as", "primary", "pulmonary", "hypertension", "." ]	[ "umlsterm" ]
prostanoids, PGE1, PGI2, pulmonary circulation, use, patients, pulmonary hypertension, lung transplantation, patients, adult, respiratory distress syndrome, ARDS, PGE1, PGI2, vascular resistance, pressure, gas, PGI2, aerosol, vasodilator, nitric oxide, aerosol, PGI2, iloprost, long - term treatment, patients, pulmonary hypertension, pulmonary hypertension	IntensiveMedizin.70340370.eng.abstr_task2	Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .	[ "The", "vasodilatory", "prostanoids", "PGE1", "and", "PGI2", "possess", "strong", "vasodilatory", "potency", "in", "the", "pulmonary", "circulation", ".", "Their", "application", "is", ",", "however", ",", "limited", "by", "the", "lack", "of", "pulmonary", "and", "intrapulmonary", "selectivity", ".", "By", "use", "of", "chronic", "ambulatory", "PGI2-infusion", ",", "patients", "with", "primary", "pulmonary", "hypertension", "(", "PPH", ")", "may", "be", "bridged", "for", "(", "heart-", ")", "lung", "transplantation", ".", "In", "patients", "with", "adult", "respiratory", "distress", "syndrome", "(", "ARDS", ")", ",", "PGE1", "and", "PGI2", "lower", "the", "pulmonary", "vascular", "resistance", ",", "but", "may", "also", "decrease", "the", "systemic", "pressure", "(", "limited", "pulmonary", "selectivity", ")", "and", "increase", "ventilation", "-", "perfusion", "-", "mismatch", ",", "accompanied", "by", "an", "impairment", "of", "gas", "exchange", "(", "limited", "intrapulmonary", "selectivity", ")", ".", "Application", "of", "PGI2", "via", "the", "transbronchial", "route", "(", "aerosol", ")", "may", "achieve", "pulmonary", "and", "intrapulmonary", "selectivity", "with", "an", "efficacy", "profile", "comparable", "to", "that", "of", "the", "selective", "pulmonary", "vasodilator", "nitric", "oxide", "(", "NO", ")", ".", "Repetitive", "aerosol", "application", "of", "the", "stable", "PGI2", "analogue", "iloprost", "is", "under", "consideration", "for", "long", "-", "term", "treatment", "of", "patients", "with", "severe", "pulmonary", "hypertension", "such", "as", "primary", "pulmonary", "hypertension", "." ]	[ "umlsterm" ]
Berlin is an umlsterm, Unfallerfahrungen is an umlsterm, Aerzte is an umlsterm, Aerzten is an umlsterm, Aerzte is an umlsterm, Unfaellen is an umlsterm, Aerzte is an umlsterm, Unfallerfahrung is an umlsterm, Aerzte is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Rolle is an umlsterm, Patienten is an umlsterm, Befundarmut is an umlsterm, Arzt is an umlsterm	Rechtsmedizin.80080178.ger.abstr_task0	Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .	[ "Im", "Maerz", "1997", "wurden", "alle", "459", "in", "Berlin", "praktizierenden", "Chirurgen", "und", "Orthopaeden", "schriftlich", "nach", "ihren", "Erfahrungen", "mit", "atraumatischen", "und", "posttraumatischen", "HWS", "-", "Beschwerden", "befragt", ".", "Der", "Ruecklauf", "betrug", "rund", "25", "%", ".", "Bemerkenswerterweise", "beeinflussten", "persoenliche", "Unfallerfahrungen", "(", "als", "Fahrzeuginsasse", ")", "die", "Sichtweise", "der", "Aerzte", ":", "von", "den", "26", "Aerzten", "mit", "eigenen", "posttraumatischen", "HWS", "-", "Beschwerden", "hielten", "54", "%", "eine", "solche", "Symptomatik", "fuer", "traumaspezifisch", ",", "waehrend", "dies", "nur", "35", "%", "der", "40", "Aerzte", "mit", "Unfaellen", ",", "aber", "ohne", "HWS", "-", "Beschwerden", "so", "sahen", ".", "22", "%", "der", "Aerzte", "ohne", "Unfallerfahrung", "gegenueber", "62", "%", "der", "Aerzte", "mit", "bezogen", "auf", "die", "HWS", "folgenlosem", "Unfall", "gaben", "an", ",", "materielle", "Begehrlichkeiten", "von", "Patienten", "wuerden", "haeufig", "in", "Symptomatik", "und", "Behandlung", "eine", "Rolle", "spielen", ".", "Angesichts", "seiner", "speziellen", "Beziehung", "zum", "Patienten", "sowie", "aufgrund", "der", "typischen", "Befundarmut", "des", "Beschwerdebildes", "hat", "es", "der", "behandelnde", "Arzt", "allerdings", "schwer", ",", "von", "ihm", "u.", "U.", "als", "ueberzogen", "empfundenen", "Begehrlichkeiten", "entgegenzutreten", "." ]	[ "umlsterm" ]
Berlin is an umlsterm, Unfallerfahrungen is an umlsterm, Aerzte is an umlsterm, Aerzten is an umlsterm, Aerzte is an umlsterm, Unfaellen is an umlsterm, Aerzte is an umlsterm, Unfallerfahrung is an umlsterm, Aerzte is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Rolle is an umlsterm, Patienten is an umlsterm, Befundarmut is an umlsterm, Arzt is an umlsterm	Rechtsmedizin.80080178.ger.abstr_task1	Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please typing these entity words according to sentence: Berlin, Unfallerfahrungen, Aerzte, Aerzten, Aerzte, Unfaellen, Aerzte, Unfallerfahrung, Aerzte, Unfall, Patienten, Behandlung, Rolle, Patienten, Befundarmut, Arzt Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .	[ "Im", "Maerz", "1997", "wurden", "alle", "459", "in", "Berlin", "praktizierenden", "Chirurgen", "und", "Orthopaeden", "schriftlich", "nach", "ihren", "Erfahrungen", "mit", "atraumatischen", "und", "posttraumatischen", "HWS", "-", "Beschwerden", "befragt", ".", "Der", "Ruecklauf", "betrug", "rund", "25", "%", ".", "Bemerkenswerterweise", "beeinflussten", "persoenliche", "Unfallerfahrungen", "(", "als", "Fahrzeuginsasse", ")", "die", "Sichtweise", "der", "Aerzte", ":", "von", "den", "26", "Aerzten", "mit", "eigenen", "posttraumatischen", "HWS", "-", "Beschwerden", "hielten", "54", "%", "eine", "solche", "Symptomatik", "fuer", "traumaspezifisch", ",", "waehrend", "dies", "nur", "35", "%", "der", "40", "Aerzte", "mit", "Unfaellen", ",", "aber", "ohne", "HWS", "-", "Beschwerden", "so", "sahen", ".", "22", "%", "der", "Aerzte", "ohne", "Unfallerfahrung", "gegenueber", "62", "%", "der", "Aerzte", "mit", "bezogen", "auf", "die", "HWS", "folgenlosem", "Unfall", "gaben", "an", ",", "materielle", "Begehrlichkeiten", "von", "Patienten", "wuerden", "haeufig", "in", "Symptomatik", "und", "Behandlung", "eine", "Rolle", "spielen", ".", "Angesichts", "seiner", "speziellen", "Beziehung", "zum", "Patienten", "sowie", "aufgrund", "der", "typischen", "Befundarmut", "des", "Beschwerdebildes", "hat", "es", "der", "behandelnde", "Arzt", "allerdings", "schwer", ",", "von", "ihm", "u.", "U.", "als", "ueberzogen", "empfundenen", "Begehrlichkeiten", "entgegenzutreten", "." ]	[ "umlsterm" ]
Berlin, Unfallerfahrungen, Aerzte, Aerzten, Aerzte, Unfaellen, Aerzte, Unfallerfahrung, Aerzte, Unfall, Patienten, Behandlung, Rolle, Patienten, Befundarmut, Arzt	Rechtsmedizin.80080178.ger.abstr_task2	Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .	[ "Im", "Maerz", "1997", "wurden", "alle", "459", "in", "Berlin", "praktizierenden", "Chirurgen", "und", "Orthopaeden", "schriftlich", "nach", "ihren", "Erfahrungen", "mit", "atraumatischen", "und", "posttraumatischen", "HWS", "-", "Beschwerden", "befragt", ".", "Der", "Ruecklauf", "betrug", "rund", "25", "%", ".", "Bemerkenswerterweise", "beeinflussten", "persoenliche", "Unfallerfahrungen", "(", "als", "Fahrzeuginsasse", ")", "die", "Sichtweise", "der", "Aerzte", ":", "von", "den", "26", "Aerzten", "mit", "eigenen", "posttraumatischen", "HWS", "-", "Beschwerden", "hielten", "54", "%", "eine", "solche", "Symptomatik", "fuer", "traumaspezifisch", ",", "waehrend", "dies", "nur", "35", "%", "der", "40", "Aerzte", "mit", "Unfaellen", ",", "aber", "ohne", "HWS", "-", "Beschwerden", "so", "sahen", ".", "22", "%", "der", "Aerzte", "ohne", "Unfallerfahrung", "gegenueber", "62", "%", "der", "Aerzte", "mit", "bezogen", "auf", "die", "HWS", "folgenlosem", "Unfall", "gaben", "an", ",", "materielle", "Begehrlichkeiten", "von", "Patienten", "wuerden", "haeufig", "in", "Symptomatik", "und", "Behandlung", "eine", "Rolle", "spielen", ".", "Angesichts", "seiner", "speziellen", "Beziehung", "zum", "Patienten", "sowie", "aufgrund", "der", "typischen", "Befundarmut", "des", "Beschwerdebildes", "hat", "es", "der", "behandelnde", "Arzt", "allerdings", "schwer", ",", "von", "ihm", "u.", "U.", "als", "ueberzogen", "empfundenen", "Begehrlichkeiten", "entgegenzutreten", "." ]	[ "umlsterm" ]
Technik is an umlsterm, Zona pellucida is an umlsterm, heranwachsenden is an umlsterm, Embryos is an umlsterm, Embryo is an umlsterm, Zona pellucida is an umlsterm, Schwangerschaft is an umlsterm, Technik is an umlsterm	DerGynaekologe.00330772.ger.abstr_task0	Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .	[ "Die", "Technik", "des", "assisted", "hatching", "\"", "\"", "wurde", "erstmals", "1990", "beschrieben", ".", "Durch", "die", "Erzeugung", "einer", "kuenstlichen", "Oeffnung", "in", "der", "Zona", "pellucida", "des", "heranwachsenden", "Embryos", "sollte", "gewaehrleistet", "werden", ",", "dass", "der", "Embryo", "im", "Blastozystenstadium", "zuverlaessig", "aus", "der", "Zona", "pellucida", "ausschluepft", ".", "Dies", "ist", "eine", "wesentliche", "Vorbedingung", "fuer", "eine", "erfolgreiche", "Implantation", "und", "den", "Eintritt", "einer", "Schwangerschaft", ".", "Seit", "Einfuehrung", "des", "assisted", "hatching", "\"", "\"", "werden", "die", "Bedeutung", "und", "Einsatzmoeglichkeiten", "dieser", "Technik", "kontrovers", "diskutiert", "." ]	[ "umlsterm" ]
Technik is an umlsterm, Zona pellucida is an umlsterm, heranwachsenden is an umlsterm, Embryos is an umlsterm, Embryo is an umlsterm, Zona pellucida is an umlsterm, Schwangerschaft is an umlsterm, Technik is an umlsterm	DerGynaekologe.00330772.ger.abstr_task1	Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please typing these entity words according to sentence: Technik, Zona pellucida, heranwachsenden, Embryos, Embryo, Zona pellucida, Schwangerschaft, Technik Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .	[ "Die", "Technik", "des", "assisted", "hatching", "\"", "\"", "wurde", "erstmals", "1990", "beschrieben", ".", "Durch", "die", "Erzeugung", "einer", "kuenstlichen", "Oeffnung", "in", "der", "Zona", "pellucida", "des", "heranwachsenden", "Embryos", "sollte", "gewaehrleistet", "werden", ",", "dass", "der", "Embryo", "im", "Blastozystenstadium", "zuverlaessig", "aus", "der", "Zona", "pellucida", "ausschluepft", ".", "Dies", "ist", "eine", "wesentliche", "Vorbedingung", "fuer", "eine", "erfolgreiche", "Implantation", "und", "den", "Eintritt", "einer", "Schwangerschaft", ".", "Seit", "Einfuehrung", "des", "assisted", "hatching", "\"", "\"", "werden", "die", "Bedeutung", "und", "Einsatzmoeglichkeiten", "dieser", "Technik", "kontrovers", "diskutiert", "." ]	[ "umlsterm" ]
Technik, Zona pellucida, heranwachsenden, Embryos, Embryo, Zona pellucida, Schwangerschaft, Technik	DerGynaekologe.00330772.ger.abstr_task2	Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .	[ "Die", "Technik", "des", "assisted", "hatching", "\"", "\"", "wurde", "erstmals", "1990", "beschrieben", ".", "Durch", "die", "Erzeugung", "einer", "kuenstlichen", "Oeffnung", "in", "der", "Zona", "pellucida", "des", "heranwachsenden", "Embryos", "sollte", "gewaehrleistet", "werden", ",", "dass", "der", "Embryo", "im", "Blastozystenstadium", "zuverlaessig", "aus", "der", "Zona", "pellucida", "ausschluepft", ".", "Dies", "ist", "eine", "wesentliche", "Vorbedingung", "fuer", "eine", "erfolgreiche", "Implantation", "und", "den", "Eintritt", "einer", "Schwangerschaft", ".", "Seit", "Einfuehrung", "des", "assisted", "hatching", "\"", "\"", "werden", "die", "Bedeutung", "und", "Einsatzmoeglichkeiten", "dieser", "Technik", "kontrovers", "diskutiert", "." ]	[ "umlsterm" ]
respiratory failure is an umlsterm, CRF is an umlsterm, respiratory muscles is an umlsterm, neuromuscular diseases is an umlsterm, kypho - scoliosis is an umlsterm, obstructive lung disease is an umlsterm, CRF is an umlsterm, hypercapnia is an umlsterm, hypoxemia is an umlsterm, hypercapnia is an umlsterm, respiratory muscles is an umlsterm, indicator is an umlsterm	IntensiveMedizin.70340501.eng.abstr_task0	Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .	[ "Chronic", "respiratory", "failure", "(", "CRF", ")", "is", "caused", "by", "a", "decrease", "in", "the", "capacity", "of", "the", "respiratory", "muscles", "(", "e", ".", "g", ".", ",", "neuromuscular", "diseases", ")", ",", "or", "an", "increase", "in", "load", "(", "e", ".", "g", ".", ",", "kypho", "-", "scoliosis", "or", "obstructive", "lung", "disease", ")", "or", "both", ".", "CRF", "is", "characterized", "by", "hypercapnia", "and", "hypoxemia", ".", "The", "degree", "of", "hypercapnia", "is", "directly", "related", "to", "the", "increase", "of", "the", "load", "and", "decrease", "of", "the", "capacity", "of", "the", "respiratory", "muscles", "and", "acts", ",", "therefore", ",", "as", "an", "indicator", "." ]	[ "umlsterm" ]
respiratory failure is an umlsterm, CRF is an umlsterm, respiratory muscles is an umlsterm, neuromuscular diseases is an umlsterm, kypho - scoliosis is an umlsterm, obstructive lung disease is an umlsterm, CRF is an umlsterm, hypercapnia is an umlsterm, hypoxemia is an umlsterm, hypercapnia is an umlsterm, respiratory muscles is an umlsterm, indicator is an umlsterm	IntensiveMedizin.70340501.eng.abstr_task1	Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please typing these entity words according to sentence: respiratory failure, CRF, respiratory muscles, neuromuscular diseases, kypho - scoliosis, obstructive lung disease, CRF, hypercapnia, hypoxemia, hypercapnia, respiratory muscles, indicator Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .	[ "Chronic", "respiratory", "failure", "(", "CRF", ")", "is", "caused", "by", "a", "decrease", "in", "the", "capacity", "of", "the", "respiratory", "muscles", "(", "e", ".", "g", ".", ",", "neuromuscular", "diseases", ")", ",", "or", "an", "increase", "in", "load", "(", "e", ".", "g", ".", ",", "kypho", "-", "scoliosis", "or", "obstructive", "lung", "disease", ")", "or", "both", ".", "CRF", "is", "characterized", "by", "hypercapnia", "and", "hypoxemia", ".", "The", "degree", "of", "hypercapnia", "is", "directly", "related", "to", "the", "increase", "of", "the", "load", "and", "decrease", "of", "the", "capacity", "of", "the", "respiratory", "muscles", "and", "acts", ",", "therefore", ",", "as", "an", "indicator", "." ]	[ "umlsterm" ]
respiratory failure, CRF, respiratory muscles, neuromuscular diseases, kypho - scoliosis, obstructive lung disease, CRF, hypercapnia, hypoxemia, hypercapnia, respiratory muscles, indicator	IntensiveMedizin.70340501.eng.abstr_task2	Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .	[ "Chronic", "respiratory", "failure", "(", "CRF", ")", "is", "caused", "by", "a", "decrease", "in", "the", "capacity", "of", "the", "respiratory", "muscles", "(", "e", ".", "g", ".", ",", "neuromuscular", "diseases", ")", ",", "or", "an", "increase", "in", "load", "(", "e", ".", "g", ".", ",", "kypho", "-", "scoliosis", "or", "obstructive", "lung", "disease", ")", "or", "both", ".", "CRF", "is", "characterized", "by", "hypercapnia", "and", "hypoxemia", ".", "The", "degree", "of", "hypercapnia", "is", "directly", "related", "to", "the", "increase", "of", "the", "load", "and", "decrease", "of", "the", "capacity", "of", "the", "respiratory", "muscles", "and", "acts", ",", "therefore", ",", "as", "an", "indicator", "." ]	[ "umlsterm" ]
Adipose tissue is a Tissue, endocrine tissue is a Tissue, synovial fluid is a Organism_substance, sera is a Organism_substance, synovial fibroblasts is a Cell, synovial cell is a Cell, cardiovascular is a Multi-tissue_structure, joint fluid is a Organism_substance	PMC-3003518-sec-05_task0	Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Cell, Multi-tissue_structure, Organism_substance	[ "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).	[ "Introduction", "\n", "Adipose", "tissue", ",", "once", "viewed", "as", "simply", "a", "storage", "and", "release", "depot", "for", "lipids", ",", "is", "now", "considered", "an", "endocrine", "tissue", "[", "1,2", "]", "that", "secretes", "various", "substances", "(", "adipokines", ")", ",", "including", "tumor", "necrosis", "factor", "-", "alpha", "(", "TNF", "-", "alpha", ")", ",", "interleukin", "(", "IL)-6", ",", "leptin", ",", "adiponectin", ",", "resistin", ",", "visfatin", ",", "and", "omenetin", "[", "3,4", "]", ".", "Among", "these", "adipokines", ",", "much", "attention", "has", "been", "paid", "to", "adiponectin", "'s", "relationship", "with", "insulin", "sensitivity", "and", "glucose", "and", "lipid", "metabolism", "in", "the", "past", "10", "years", ".", "In", "addition", ",", "adiponectin", "is", "known", "to", "exhibit", "potent", "anti", "-", "inflammatory", "[", "5", "]", ",", "atheroprotective", "[", "6", "]", ",", "and", "antidiabetic", "[", "7", "]", "effects", ".", "\n", "Recent", "findings", "suggest", "that", "adiponectin", "may", "be", "involved", "in", "the", "pathogenesis", "of", "rheumatoid", "arthritis", "(", "RA", ")", ".", "Levels", "of", "adiponectin", "in", "synovial", "fluid", "and", "sera", "were", "elevated", "in", "patients", "with", "RA", "[", "8,9", "]", ".", "Adiponectin", "also", "induces", "the", "production", "of", "proinflammatory", "cytokines", ",", "IL-6", ",", "matrix", "metalloproteinase", "(", "MMP)-1", ",", "and", "IL-8", "from", "RA", "synovial", "fibroblasts", "in", "vitro", "[", "10,11", "]", ".", "Thus", ",", "it", "was", "suggested", "that", "adiponectin", "can", "also", "exert", "significant", "proinflammatory", "and", "matrix", "-", "degrading", "effects", ".", "However", ",", "the", "role", "of", "adiponectin", "in", "the", "pathogenesis", "of", "RA", "is", "still", "controversial", "because", "of", "conflicting", "reports", "about", "its", "function", "[", "10,12", "-", "15", "]", ".", "In", "particular", ",", "adiponectin", "seems", "to", "play", "an", "anti", "-", "inflammatory", "role", "because", "it", "significantly", "inhibited", "IL-1beta", "-", "stimulated", "synovial", "cell", "proliferation", "in", "collagen", "-", "induced", "arthritic", "mice", ",", "despite", "increased", "IL-6", "expression", "[", "16", "]", ".", "In", "contrast", ",", "high", "-", "grade", "inflammation", "in", "RA", "patients", "was", "negatively", "correlated", "with", "circulating", "adiponectin", "concentrations", "[", "17", "]", ".", "Rather", ",", "it", "was", "suggested", "that", "circulating", "adiponectin", "may", "be", "involved", "in", "cardiovascular", "disease", "in", "RA", "patients", ".", "Although", "this", "contradiction", "was", "partly", "explained", "by", "the", "induction", "of", "tolerance", "to", "inflammatory", "stimuli", "by", "adiponectin", "[", "18", "]", ",", "the", "pro-", "or", "anti", "-", "inflammatory", "effects", "of", "adiponectin", "on", "the", "pathogenesis", "of", "RA", "remain", "unknown", ".", "\n", "With", "regard", "to", "adiponectin", "'s", "proinflammatory", "effects", ",", "we", "wondered", "whether", "adiponectin", "might", "stimulate", "the", "production", "of", "vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "MMPs", "as", "well", "as", "proinflammatory", "mediators", "like", "IL-1beta", "and", "TNF", "-", "alpha", "do", ".", "In", "this", "study", ",", "we", "investigated", "the", "stimulatory", "effect", "of", "adiponectin", "on", "the", "production", "of", "IL-6", ",", "IL-8", ",", "prostaglandin", "E2", "(", "PGE2", ")", ",", "VEGF", ",", "and", "MMPs", ".", "In", "addition", ",", "the", "correlation", "between", "adiponectin", "and", "VEGF", "or", "MMPs", "was", "investigated", "by", "measuring", "the", "levels", "of", "these", "three", "proteins", "in", "the", "joint", "fluid", "of", "patients", "with", "RA", "or", "osteoarthritis", "(", "OA", ")", ".", "\n" ]	[ "Cell", "Tissue", "Organism_substance", "Multi-tissue_structure" ]
Adipose tissue is a Tissue, endocrine tissue is a Tissue, synovial fluid is a Organism_substance, sera is a Organism_substance, synovial fibroblasts is a Cell, synovial cell is a Cell, cardiovascular is a Multi-tissue_structure, joint fluid is a Organism_substance	PMC-3003518-sec-05_task1	Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please typing these entity words according to sentence: Adipose tissue, endocrine tissue, synovial fluid, sera, synovial fibroblasts, synovial cell, cardiovascular, joint fluid Options: Tissue, Cell, Multi-tissue_structure, Organism_substance	[ "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).	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Adipose tissue, endocrine tissue, synovial fluid, sera, synovial fibroblasts, synovial cell, cardiovascular, joint fluid	PMC-3003518-sec-05_task2	Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "I-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).	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muscle is a Organ, joint is a Multi-tissue_structure, body surface area is a Organism_subdivision, dermal is a Multi-tissue_structure, epidermal is a Multi-tissue_structure	PMID-21915357_task0	Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Multi-tissue_structure, Organism_subdivision, Organ	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_subdivision", "I-Organism_subdivision", "I-Organism_subdivision", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.	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muscle is a Organ, joint is a Multi-tissue_structure, body surface area is a Organism_subdivision, dermal is a Multi-tissue_structure, epidermal is a Multi-tissue_structure	PMID-21915357_task1	Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please typing these entity words according to sentence: muscle, joint, body surface area, dermal, epidermal Options: Multi-tissue_structure, Organism_subdivision, Organ	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_subdivision", "I-Organism_subdivision", "I-Organism_subdivision", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.	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muscle, joint, body surface area, dermal, epidermal	PMID-21915357_task2	Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism_subdivision", "I-Organism_subdivision", "I-Organism_subdivision", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.	[ "Burns", "from", "hot", "wheat", "bags", ":", "a", "public", "safety", "issue", ".", "\n", "Introduction", ":", "Wheat", "bags", "are", "therapeutic", "devices", "that", "are", "heated", "in", "microwaves", "and", "commonly", "used", "to", "provide", "relief", "from", "muscle", "and", "joint", "pain", ".", "The", "Royal", "Adelaide", "Hospital", "Burns", "Unit", "has", "observed", "a", "number", "of", "patients", "with", "significant", "burn", "injuries", "resulting", "from", "their", "use", ".", "Despite", "their", "dangers", ",", "the", "products", "come", "with", "limited", "safety", "information", ".", "Methods", ":", "Data", "were", "collected", "from", "the", "Burns", "Unit", "database", "for", "all", "patients", "admitted", "with", "burns", "due", "to", "hot", "wheat", "bags", "from", "2004", "to", "2009", ".", "This", "was", "analyzed", "to", "determine", "the", "severity", "of", "the", "burn", "injury", "and", "identify", "any", "predisposing", "factors", ".", "An", "experimental", "study", "was", "performed", "to", "measure", "the", "temperature", "of", "wheat", "bags", "when", "heated", "to", "determine", "their", "potential", "for", "causing", "thermal", "injury", ".", "Results", ":", "11", "patients", "were", "admitted", "with", "burns", "due", "to", "hot", "wheat", "bags", ".", "The", "median", "age", "was", "52", "years", "and", "the", "mean", "total", "body", "surface", "area", "was", "1.1", "%", ".", "All", "burns", "were", "either", "deep", "dermal", "(", "45.5", "%", ")", "or", "full", "thickness", "(", "54.5", "%", ")", ".", "Ten", "patients", "required", "operative", "management", ".", "Predisposing", "factors", "(", "eg", ",", "neuropathy", ")", "to", "thermal", "injury", "were", "identified", "in", "7", "patients", ".", "The", "experimental", "study", "showed", "that", "hot", "wheat", "bags", "reached", "temperatures", "of", "57.3degreesC", "(", "135.1degreesF", ")", "when", "heated", "according", "to", "instructions", ",", "63.3degreesC", "(", "145.9degreesF", ")", "in", "a", "1000", "W", "microwave", "and", "69.6degreesC", "(", "157.3degreesF", ")", "on", "reheating", ".", "Conclusions", ":", "Hot", "wheat", "bags", "cause", "serious", "burn", "injury", ".", "When", "heated", "improperly", ",", "they", "can", "reach", "temperatures", "high", "enough", "to", "cause", "epidermal", "necrosis", "in", "a", "short", "period", "of", "time", ".", "Patients", "with", "impaired", "temperature", "sensation", "are", "particularly", "at", "risk", ".", "There", "should", "be", "greater", "public", "awareness", "of", "the", "dangers", "of", "wheat", "bag", "use", "and", "more", "specific", "safety", "warnings", "on", "the", "products", ".", "\n" ]	[ "Organism_subdivision", "Multi-tissue_structure", "Organ" ]
Iron is a CHEMICAL, zinc is a CHEMICAL, caseinophosphopeptides is a GENE-N, caseinophosphopeptides is a GENE-N, CPPs is a GENE-N, α(s)- and β - casein is a GENE-N, CN is a GENE-N, CPPs is a GENE-N, iron is a CHEMICAL, ferritin is a GENE-Y, zinc is a CHEMICAL, zinc is a CHEMICAL, α - CPP is a GENE-N, β - CPP is a GENE-N, ferritin is a GENE-Y, CPPs is a GENE-N, ferritin is a GENE-Y, iron sulphate is a CHEMICAL, zinc is a CHEMICAL, α - CPPs is a GENE-N, β - CPPs is a GENE-N, zinc is a CHEMICAL, zinc sulphate is a CHEMICAL	4262_task0	Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.	[ "Iron", "and", "zinc", "bioavailability", "in", "Caco-2", "cells", ":", "influence", "of", "caseinophosphopeptides", ".", "\n", "A", "study", "has", "been", "made", "of", "the", "influence", "of", "two", "pools", "of", "caseinophosphopeptides", "(", "CPPs", ")", "obtained", "from", "α(s)-", "and", "β", "-", "casein", "(", "CN", ")", "fractions", ",", "and", "of", "three", "specific", "CPPs", "(", "β", "-", "CN(1", "-", "25)4P", ",", "α(s1)-CN(64", "-", "74)4P", "and", "α(s2)-CN(1", "-", "19)4P", ")", ",", "on", "iron", "bioavailability", "(", "ferritin", "synthesis", ")", "and", "zinc", "bioavailability", "(", "retention", ",", "transport", "and", "uptake", "of", "zinc", ")", "in", "Caco-2", "cells", ".", "α", "-", "CPP", "and", "β", "-", "CPP", "pools", "did", "not", "improve", "ferritin", "synthesis", ",", "but", "the", "three", "specific", "CPPs", "showed", "an", "increase", "in", "ferritin", "synthesis", "in", "Caco-2", "cells", "versus", "iron", "sulphate", ",", "β", "-", "CN(1", "-", "25)4P", "being", "the", "most", "effective", ".", "In", "relation", "to", "zinc", "bioavailability", ",", "α", "-", "CPPs", ",", "β", "-", "CPPs", ",", "α(s1)-CN(64", "-", "74)4P", "and", "β", "-", "CN(1", "-", "25)4P", "increased", "zinc", "uptake", ".", "However", ",", "this", "increase", "was", "of", "the", "same", "order", "as", "the", "increase", "due", "to", "the", "presence", "of", "zinc", "sulphate", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Iron is a CHEMICAL, zinc is a CHEMICAL, caseinophosphopeptides is a GENE-N, caseinophosphopeptides is a GENE-N, CPPs is a GENE-N, α(s)- and β - casein is a GENE-N, CN is a GENE-N, CPPs is a GENE-N, iron is a CHEMICAL, ferritin is a GENE-Y, zinc is a CHEMICAL, zinc is a CHEMICAL, α - CPP is a GENE-N, β - CPP is a GENE-N, ferritin is a GENE-Y, CPPs is a GENE-N, ferritin is a GENE-Y, iron sulphate is a CHEMICAL, zinc is a CHEMICAL, α - CPPs is a GENE-N, β - CPPs is a GENE-N, zinc is a CHEMICAL, zinc sulphate is a CHEMICAL	4262_task1	Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please typing these entity words according to sentence: Iron, zinc, caseinophosphopeptides, caseinophosphopeptides, CPPs, α(s)- and β - casein, CN, CPPs, iron, ferritin, zinc, zinc, α - CPP, β - CPP, ferritin, CPPs, ferritin, iron sulphate, zinc, α - CPPs, β - CPPs, zinc, zinc sulphate Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.	[ "Iron", "and", "zinc", "bioavailability", "in", "Caco-2", "cells", ":", "influence", "of", "caseinophosphopeptides", ".", "\n", "A", "study", "has", "been", "made", "of", "the", "influence", "of", "two", "pools", "of", "caseinophosphopeptides", "(", "CPPs", ")", "obtained", "from", "α(s)-", "and", "β", "-", "casein", "(", "CN", ")", "fractions", ",", "and", "of", "three", "specific", "CPPs", "(", "β", "-", "CN(1", "-", "25)4P", ",", "α(s1)-CN(64", "-", "74)4P", "and", "α(s2)-CN(1", "-", "19)4P", ")", ",", "on", "iron", "bioavailability", "(", "ferritin", "synthesis", ")", "and", "zinc", "bioavailability", "(", "retention", ",", "transport", "and", "uptake", "of", "zinc", ")", "in", "Caco-2", "cells", ".", "α", "-", "CPP", "and", "β", "-", "CPP", "pools", "did", "not", "improve", "ferritin", "synthesis", ",", "but", "the", "three", "specific", "CPPs", "showed", "an", "increase", "in", "ferritin", "synthesis", "in", "Caco-2", "cells", "versus", "iron", "sulphate", ",", "β", "-", "CN(1", "-", "25)4P", "being", "the", "most", "effective", ".", "In", "relation", "to", "zinc", "bioavailability", ",", "α", "-", "CPPs", ",", "β", "-", "CPPs", ",", "α(s1)-CN(64", "-", "74)4P", "and", "β", "-", "CN(1", "-", "25)4P", "increased", "zinc", "uptake", ".", "However", ",", "this", "increase", "was", "of", "the", "same", "order", "as", "the", "increase", "due", "to", "the", "presence", "of", "zinc", "sulphate", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Iron, zinc, caseinophosphopeptides, caseinophosphopeptides, CPPs, α(s)- and β - casein, CN, CPPs, iron, ferritin, zinc, zinc, α - CPP, β - CPP, ferritin, CPPs, ferritin, iron sulphate, zinc, α - CPPs, β - CPPs, zinc, zinc sulphate	4262_task2	Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.	[ "Iron", "and", "zinc", "bioavailability", "in", "Caco-2", "cells", ":", "influence", "of", "caseinophosphopeptides", ".", "\n", "A", "study", "has", "been", "made", "of", "the", "influence", "of", "two", "pools", "of", "caseinophosphopeptides", "(", "CPPs", ")", "obtained", "from", "α(s)-", "and", "β", "-", "casein", "(", "CN", ")", "fractions", ",", "and", "of", "three", "specific", "CPPs", "(", "β", "-", "CN(1", "-", "25)4P", ",", "α(s1)-CN(64", "-", "74)4P", "and", "α(s2)-CN(1", "-", "19)4P", ")", ",", "on", "iron", "bioavailability", "(", "ferritin", "synthesis", ")", "and", "zinc", "bioavailability", "(", "retention", ",", "transport", "and", "uptake", "of", "zinc", ")", "in", "Caco-2", "cells", ".", "α", "-", "CPP", "and", "β", "-", "CPP", "pools", "did", "not", "improve", "ferritin", "synthesis", ",", "but", "the", "three", "specific", "CPPs", "showed", "an", "increase", "in", "ferritin", "synthesis", "in", "Caco-2", "cells", "versus", "iron", "sulphate", ",", "β", "-", "CN(1", "-", "25)4P", "being", "the", "most", "effective", ".", "In", "relation", "to", "zinc", "bioavailability", ",", "α", "-", "CPPs", ",", "β", "-", "CPPs", ",", "α(s1)-CN(64", "-", "74)4P", "and", "β", "-", "CN(1", "-", "25)4P", "increased", "zinc", "uptake", ".", "However", ",", "this", "increase", "was", "of", "the", "same", "order", "as", "the", "increase", "due", "to", "the", "presence", "of", "zinc", "sulphate", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Self Psychology is an umlsterm, analysis is an umlsterm, self is an umlsterm, empathy is an umlsterm, treatment is an umlsterm, patients is an umlsterm, disorder is an umlsterm, line is an umlsterm, self is an umlsterm, aggressive behaviour is an umlsterm, self is an umlsterm, self is an umlsterm, selfobject is an umlsterm, disorders is an umlsterm, self is an umlsterm, Selfobject is an umlsterm, lead is an umlsterm, forms is an umlsterm, transference is an umlsterm, Self Psychology is an umlsterm, therapeutic process is an umlsterm, infant is an umlsterm, research is an umlsterm, Self Psychology is an umlsterm, conflict is an umlsterm, survey is an umlsterm, Self Psychology is an umlsterm	Psychotherapeut.60410001.eng.abstr_task0	Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .	[ "Psychoanalytic", "Self", "Psychology", "is", "presented", "as", "a", "postmodern", "paradigm", "for", "the", "analysis", "of", "the", "postpatriarchical", "self", "with", "the", "methodological", "approach", "of", "introspection", "and", "empathy", ".", "The", "limited", "possibilities", "of", "psychoanalytic", "treatment", "particularly", "with", "patients", "with", "a", "narcissistic", "disorder", "led", "Heinz", "Kohut", "to", "the", "hypothesis", "of", "a", "particular", "developmental", "line", "of", "narcissism", "and", "the", "motivational", "primacy", "of", "the", "self", "which", "he", "conceptualized", "as", "bipolar", ".", "Sexual", "and", "aggressive", "behaviour", "is", "subsequently", "seen", "as", "primary", "only", "if", "there", "is", "a", "coherent", ",", "vital", "and", "not", "fragmented", "self", ".", "Substantial", "conditions", "of", "self", "coherence", "are", "selfobject", "experiences", ",", "which", "are", "presented", "in", "their", "multiplicity", "as", "are", "disorders", "of", "the", "self", ".", "Selfobject", "experiences", "lead", "to", "the", "main", "forms", "of", "transference", "as", "seen", "by", "Psychoanalatic", "Self", "Psychology", ".", "A", "short", "synopsis", "of", "the", "therapeutic", "process", "and", "of", "the", "integration", "of", "infant", "research", "into", "Self", "Psychology", "as", "well", "as", "a", "different", "view", "of", "the", "oedipal", "conflict", "completes", "this", "survey", "together", "with", "some", "final", "remarks", "about", "a", "few", "new", "concepts", "in", "Psychoanalytic", "Self", "Psychology", "." ]	[ "umlsterm" ]
Self Psychology is an umlsterm, analysis is an umlsterm, self is an umlsterm, empathy is an umlsterm, treatment is an umlsterm, patients is an umlsterm, disorder is an umlsterm, line is an umlsterm, self is an umlsterm, aggressive behaviour is an umlsterm, self is an umlsterm, self is an umlsterm, selfobject is an umlsterm, disorders is an umlsterm, self is an umlsterm, Selfobject is an umlsterm, lead is an umlsterm, forms is an umlsterm, transference is an umlsterm, Self Psychology is an umlsterm, therapeutic process is an umlsterm, infant is an umlsterm, research is an umlsterm, Self Psychology is an umlsterm, conflict is an umlsterm, survey is an umlsterm, Self Psychology is an umlsterm	Psychotherapeut.60410001.eng.abstr_task1	Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please typing these entity words according to sentence: Self Psychology, analysis, self, empathy, treatment, patients, disorder, line, self, aggressive behaviour, self, self, selfobject, disorders, self, Selfobject, lead, forms, transference, Self Psychology, therapeutic process, infant, research, Self Psychology, conflict, survey, Self Psychology Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .	[ "Psychoanalytic", "Self", "Psychology", "is", "presented", "as", "a", "postmodern", "paradigm", "for", "the", "analysis", "of", "the", "postpatriarchical", "self", "with", "the", "methodological", "approach", "of", "introspection", "and", "empathy", ".", "The", "limited", "possibilities", "of", "psychoanalytic", "treatment", "particularly", "with", "patients", "with", "a", "narcissistic", "disorder", "led", "Heinz", "Kohut", "to", "the", "hypothesis", "of", "a", "particular", "developmental", "line", "of", "narcissism", "and", "the", "motivational", "primacy", "of", "the", "self", "which", "he", "conceptualized", "as", "bipolar", ".", "Sexual", "and", "aggressive", "behaviour", "is", "subsequently", "seen", "as", "primary", "only", "if", "there", "is", "a", "coherent", ",", "vital", "and", "not", "fragmented", "self", ".", "Substantial", "conditions", "of", "self", "coherence", "are", "selfobject", "experiences", ",", "which", "are", "presented", "in", "their", "multiplicity", "as", "are", "disorders", "of", "the", "self", ".", "Selfobject", "experiences", "lead", "to", "the", "main", "forms", "of", "transference", "as", "seen", "by", "Psychoanalatic", "Self", "Psychology", ".", "A", "short", "synopsis", "of", "the", "therapeutic", "process", "and", "of", "the", "integration", "of", "infant", "research", "into", "Self", "Psychology", "as", "well", "as", "a", "different", "view", "of", "the", "oedipal", "conflict", "completes", "this", "survey", "together", "with", "some", "final", "remarks", "about", "a", "few", "new", "concepts", "in", "Psychoanalytic", "Self", "Psychology", "." ]	[ "umlsterm" ]
Self Psychology, analysis, self, empathy, treatment, patients, disorder, line, self, aggressive behaviour, self, self, selfobject, disorders, self, Selfobject, lead, forms, transference, Self Psychology, therapeutic process, infant, research, Self Psychology, conflict, survey, Self Psychology	Psychotherapeut.60410001.eng.abstr_task2	Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .	[ "Psychoanalytic", "Self", "Psychology", "is", "presented", "as", "a", "postmodern", "paradigm", "for", "the", "analysis", "of", "the", "postpatriarchical", "self", "with", "the", "methodological", "approach", "of", "introspection", "and", "empathy", ".", "The", "limited", "possibilities", "of", "psychoanalytic", "treatment", "particularly", "with", "patients", "with", "a", "narcissistic", "disorder", "led", "Heinz", "Kohut", "to", "the", "hypothesis", "of", "a", "particular", "developmental", "line", "of", "narcissism", "and", "the", "motivational", "primacy", "of", "the", "self", "which", "he", "conceptualized", "as", "bipolar", ".", "Sexual", "and", "aggressive", "behaviour", "is", "subsequently", "seen", "as", "primary", "only", "if", "there", "is", "a", "coherent", ",", "vital", "and", "not", "fragmented", "self", ".", "Substantial", "conditions", "of", "self", "coherence", "are", "selfobject", "experiences", ",", "which", "are", "presented", "in", "their", "multiplicity", "as", "are", "disorders", "of", "the", "self", ".", "Selfobject", "experiences", "lead", "to", "the", "main", "forms", "of", "transference", "as", "seen", "by", "Psychoanalatic", "Self", "Psychology", ".", "A", "short", "synopsis", "of", "the", "therapeutic", "process", "and", "of", "the", "integration", "of", "infant", "research", "into", "Self", "Psychology", "as", "well", "as", "a", "different", "view", "of", "the", "oedipal", "conflict", "completes", "this", "survey", "together", "with", "some", "final", "remarks", "about", "a", "few", "new", "concepts", "in", "Psychoanalytic", "Self", "Psychology", "." ]	[ "umlsterm" ]
thiazides is a GROUP, diuretics is a GROUP, corticosteroids is a GROUP, phenothiazines is a GROUP, thyroid products is a GROUP, estrogens is a GROUP, contraceptives is a GROUP, phenytoin is a DRUG, nicotinic acid is a DRUG, sympathomimetics is a GROUP, calcium channel - blocking drugs is a GROUP, isoniazid is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, sulfonylureas is a GROUP, insulin is a DRUG, Intestinal adsorbents is a GROUP, charcoal is a DRUG, digestive enzyme preparations is a GROUP, amylase is a DRUG, pancreatin is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, nifedipine is a DRUG, propranolol is a DRUG, ranitidine is a DRUG, Acarbose is a DRUG, sulfonylurea is a DRUG, glyburide is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG	Acarbose_ddi_task0	Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O" ]	Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.	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thiazides is a GROUP, diuretics is a GROUP, corticosteroids is a GROUP, phenothiazines is a GROUP, thyroid products is a GROUP, estrogens is a GROUP, contraceptives is a GROUP, phenytoin is a DRUG, nicotinic acid is a DRUG, sympathomimetics is a GROUP, calcium channel - blocking drugs is a GROUP, isoniazid is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, sulfonylureas is a GROUP, insulin is a DRUG, Intestinal adsorbents is a GROUP, charcoal is a DRUG, digestive enzyme preparations is a GROUP, amylase is a DRUG, pancreatin is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, nifedipine is a DRUG, propranolol is a DRUG, ranitidine is a DRUG, Acarbose is a DRUG, sulfonylurea is a DRUG, glyburide is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG	Acarbose_ddi_task1	Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please typing these entity words according to sentence: thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel - blocking drugs, isoniazid, Acarbose, Acarbose, sulfonylureas, insulin, Intestinal adsorbents, charcoal, digestive enzyme preparations, amylase, pancreatin, Acarbose, Acarbose, digoxin, digoxin, Acarbose, digoxin, nifedipine, propranolol, ranitidine, Acarbose, sulfonylurea, glyburide, Acarbose, digoxin, digoxin, digoxin, digoxin, metformin, Acarbose, metformin, Acarbose, metformin, Acarbose, metformin Options: GROUP, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O" ]	Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.	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thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel - blocking drugs, isoniazid, Acarbose, Acarbose, sulfonylureas, insulin, Intestinal adsorbents, charcoal, digestive enzyme preparations, amylase, pancreatin, Acarbose, Acarbose, digoxin, digoxin, Acarbose, digoxin, nifedipine, propranolol, ranitidine, Acarbose, sulfonylurea, glyburide, Acarbose, digoxin, digoxin, digoxin, digoxin, metformin, Acarbose, metformin, Acarbose, metformin, Acarbose, metformin	Acarbose_ddi_task2	Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O" ]	Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.	[ "Certain", "drugs", "tend", "to", "produce", "hyperglycemia", "and", "may", "lead", "to", "loss", "of", "blood", "glucose", "control", ".", "These", "drugs", "include", "the", "thiazides", "and", "other", "diuretics", ",", "corticosteroids", ",", "phenothiazines", ",", "thyroid", "products", ",", "estrogens", ",", "oral", "contraceptives", ",", "phenytoin", ",", "nicotinic", "acid", ",", "sympathomimetics", ",", "calcium", "channel", "-", "blocking", "drugs", ",", "and", "isoniazid", ".", "When", "such", "drugs", "are", "administered", "to", "a", "patient", "receiving", "Acarbose", ",", "the", "patient", "should", "be", "closely", "observed", "for", "loss", "of", "blood", "glucose", "control", ".", "When", "such", "drugs", "are", "withdrawn", "from", "patients", "receiving", "Acarbose", "in", "combination", "with", "sulfonylureas", "or", "insulin", ",", "patients", "should", "be", "observed", "closely", "for", "any", "evidence", "of", "hypoglycemia", ".", "Intestinal", "adsorbents", "(", "e.", "g.", ",", "charcoal", ")", "and", "digestive", "enzyme", "preparations", "containing", "carbohydrate", "-", "splitting", "enzymes", "(", "e.", "g.", ",", "amylase", ",", "pancreatin", ")", "may", "reduce", "the", "effect", "of", "Acarbose", "and", "should", "not", "be", "taken", "concomitantly", ".", "Acarbose", "has", "been", "shown", "to", "change", "the", "bioavailabillty", "digoxin", "when", "they", "are", "co", "-", "administered", ",", "which", "may", "require", "digoxin", "dose", "adjustment", ".", "Studies", "in", "healthy", "volunteers", "have", "shown", "that", "Acarbose", "has", "no", "effect", "on", "either", "the", "pharmacokinetics", "or", "pharmacodynamics", "of", "digoxin", ",", "nifedipine", ",", "propranolol", ",", "or", "ranitidine", ".", "Acarbose", "did", "not", "interfere", "with", "the", "absorption", "or", "disposition", "of", "the", "sulfonylurea", "glyburide", "in", "diabetic", "patients", ".", "Acarbose", "may", "affect", "digoxin", "bioavailabillty", "and", "may", "require", "dose", "adjustment", "of", "digoxin", "by", "16", "%", "(", "90", "%", "confidence", "interval", ":", "8", "-", "23", "%", ")", ",", "decrease", "mean", "C", "max", "digoxin", "by", "26", "%", "(", "90", "%", "confidence", "interval", ":", "16", "-", "34", "%", ")", "and", "decrease", "mean", "trough", "concentrations", "of", "digoxin", "by", "9", "%", "(", "90", "%", "confidence", "limit", ":", "19", "%", "decrease", "to", "2", "%", "increase", ")", ".", "The", "amount", "of", "metformin", "absorbed", "while", "taking", "Acarbose", "was", "bioequivalent", "to", "the", "amount", "absorbed", "when", "taking", "placebo", ",", "as", "indicated", "by", "the", "plasma", "AUC", "values", ".", "However", ",", "the", "peak", "plasma", "level", "of", "metformin", "was", "reduced", "by", "approximately", "20", "%", "when", "taking", "Acarbose", "due", "to", "a", "slight", "delay", "in", "the", "absorption", "of", "metformin", ".", "There", "is", "little", "if", "any", "clinically", "significant", "interaction", "between", "Acarbose", "and", "metformin", "." ]	[ "GROUP", "DRUG" ]
Ikaros gene is a DNA_domain_or_region, lymphocyte development and homeostasis is a (AND other_name other_name)	68502_task0	Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, (AND other_name other_name)	[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]	The role of the Ikaros gene in lymphocyte development and homeostasis.	[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]
Ikaros gene is a DNA_domain_or_region, lymphocyte development and homeostasis is a (AND other_name other_name)	68502_task1	Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please typing these entity words according to sentence: Ikaros gene, lymphocyte development and homeostasis Options: DNA_domain_or_region, (AND other_name other_name)	[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]	The role of the Ikaros gene in lymphocyte development and homeostasis.	[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]
Ikaros gene, lymphocyte development and homeostasis	68502_task2	Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]	The role of the Ikaros gene in lymphocyte development and homeostasis.	[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]
biosensor is an umlsterm, technology is an umlsterm, measurement is an umlsterm, plasma is an umlsterm, concentrations is an umlsterm, critical care is an umlsterm, biosensor is an umlsterm, Diagnostics is an umlsterm, device is an umlsterm, goal is an umlsterm, methods is an umlsterm	DerAnaesthesist.80470968.eng.abstr_task0	Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .	[ "The", "introduction", "of", "biosensor", "technology", "for", "near", "bedside", "measurement", "of", "plasma", "lactate", "concentrations", "has", "been", "a", "promising", "step", "for", "critical", "care", "profiling", ".", "However", ",", "methodological", "drawbacks", "and", "relevant", "inaccuracy", "have", "been", "reported", ".", "With", "the", "advent", "of", "a", "new", "biosensor", "(", "Chiron", "Diagnostics", ")", "and", "a", "revised", "NOVA", "Biomedical", "device", ",", "accuracy", "was", "expected", "to", "be", "improved", ".", "The", "goal", "of", "the", "present", "investigation", "was", "to", "evaluate", "the", "accuracy", "of", "both", "methods", "." ]	[ "umlsterm" ]
biosensor is an umlsterm, technology is an umlsterm, measurement is an umlsterm, plasma is an umlsterm, concentrations is an umlsterm, critical care is an umlsterm, biosensor is an umlsterm, Diagnostics is an umlsterm, device is an umlsterm, goal is an umlsterm, methods is an umlsterm	DerAnaesthesist.80470968.eng.abstr_task1	Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please typing these entity words according to sentence: biosensor, technology, measurement, plasma, concentrations, critical care, biosensor, Diagnostics, device, goal, methods Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .	[ "The", "introduction", "of", "biosensor", "technology", "for", "near", "bedside", "measurement", "of", "plasma", "lactate", "concentrations", "has", "been", "a", "promising", "step", "for", "critical", "care", "profiling", ".", "However", ",", "methodological", "drawbacks", "and", "relevant", "inaccuracy", "have", "been", "reported", ".", "With", "the", "advent", "of", "a", "new", "biosensor", "(", "Chiron", "Diagnostics", ")", "and", "a", "revised", "NOVA", "Biomedical", "device", ",", "accuracy", "was", "expected", "to", "be", "improved", ".", "The", "goal", "of", "the", "present", "investigation", "was", "to", "evaluate", "the", "accuracy", "of", "both", "methods", "." ]	[ "umlsterm" ]
biosensor, technology, measurement, plasma, concentrations, critical care, biosensor, Diagnostics, device, goal, methods	DerAnaesthesist.80470968.eng.abstr_task2	Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .	[ "The", "introduction", "of", "biosensor", "technology", "for", "near", "bedside", "measurement", "of", "plasma", "lactate", "concentrations", "has", "been", "a", "promising", "step", "for", "critical", "care", "profiling", ".", "However", ",", "methodological", "drawbacks", "and", "relevant", "inaccuracy", "have", "been", "reported", ".", "With", "the", "advent", "of", "a", "new", "biosensor", "(", "Chiron", "Diagnostics", ")", "and", "a", "revised", "NOVA", "Biomedical", "device", ",", "accuracy", "was", "expected", "to", "be", "improved", ".", "The", "goal", "of", "the", "present", "investigation", "was", "to", "evaluate", "the", "accuracy", "of", "both", "methods", "." ]	[ "umlsterm" ]
Humangenetik is an umlsterm, Universitaet is an umlsterm, Goettingen is an umlsterm, Chromosomenanomalien is an umlsterm, Oestriol is an umlsterm, AFP is an umlsterm, Chromosomenanomalien is an umlsterm, Patientenkollektiv is an umlsterm, Verwendung is an umlsterm, Deutschland is an umlsterm, gestationsbezogene is an umlsterm, Fruchttod is an umlsterm, Hydrops fetalis is an umlsterm, X - chromosomale is an umlsterm, Ichthyose is an umlsterm, Spezifitaet is an umlsterm	Reproduktionsmedizin.90150276.ger.abstr_task0	Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .	[ "Zwischen", "Ende", "1989", "und", "Anfang", "1999", "wurden", "am", "Institut", "fuer", "Humangenetik", "der", "Universitaet", "Goettingen", "33", "774", "routinemaessige", "Untersuchungen", "zur", "Risikospezifizierung", "fetaler", "Chromosomenanomalien", "und", "Verschlussstoerungen", "auf", "der", "Grundlage", "des", "muetterlichen", "Altersrisikos", "und", "der", "Serumparameter", "humanes", "Choriongonadotropin", "(", "hCG", ")", ",", "unkonjugiertes", "Oestriol", "(", "uE3", ")", "und", "Alpha", "-", "Fetoprotein", "(", "AFP", ")", "durchgefuehrt", ".", "Die", "prospektiv", "ermittelten", "Ergebnisse", "bestaetigen", "die", "Aussagen", "bisheriger", "retro-", "und", "prospektiver", "Studien", "zur", "Wertigkeit", "des", "sog", ".", "\"", "Triple", "-", "Tests", "\"", ".", "54", "fetale", "Chromosomenanomalien", "und", "27", "Verschlussstoerungen", "(", "Neural-", "und", "Bauchwanddefekte", ")", "wurden", "in", "diesem", "Patientenkollektiv", "unter", "Verwendung", "der", "in", "Deutschland", "ueblichen", "Grenzwerte", "erkannt", ".", "Es", "konnte", "festgestellt", "werden", ",", "dass", "ueber", "die", "eigentliche", "Zielgruppe", "hinaus", "regelmaessig", "weitere", "fetale", "und", "gestationsbezogene", "Stoerungen", "durch", "Extremwerte", "einzelner", "Serumparameter", "auffallen", "(", "z", ".", "B.", "intrauteriner", "Fruchttod", ",", "Hydrops", "fetalis", ",", "X", "-", "chromosomale", "Ichthyose", ")", ".", "Eigene", "Ergebnisse", "sowie", "Erkenntnisse", "zur", "Reduzierung", "systematischer", "Fehlerquellen", "und", "zur", "Verbesserung", "der", "Spezifitaet", "des", "Tests", "wurden", "gesammelt", "und", "sollen", "hier", "vorgestellt", "werden", "." ]	[ "umlsterm" ]
Humangenetik is an umlsterm, Universitaet is an umlsterm, Goettingen is an umlsterm, Chromosomenanomalien is an umlsterm, Oestriol is an umlsterm, AFP is an umlsterm, Chromosomenanomalien is an umlsterm, Patientenkollektiv is an umlsterm, Verwendung is an umlsterm, Deutschland is an umlsterm, gestationsbezogene is an umlsterm, Fruchttod is an umlsterm, Hydrops fetalis is an umlsterm, X - chromosomale is an umlsterm, Ichthyose is an umlsterm, Spezifitaet is an umlsterm	Reproduktionsmedizin.90150276.ger.abstr_task1	Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please typing these entity words according to sentence: Humangenetik, Universitaet, Goettingen, Chromosomenanomalien, Oestriol, AFP, Chromosomenanomalien, Patientenkollektiv, Verwendung, Deutschland, gestationsbezogene, Fruchttod, Hydrops fetalis, X - chromosomale, Ichthyose, Spezifitaet Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .	[ "Zwischen", "Ende", "1989", "und", "Anfang", "1999", "wurden", "am", "Institut", "fuer", "Humangenetik", "der", "Universitaet", "Goettingen", "33", "774", "routinemaessige", "Untersuchungen", "zur", "Risikospezifizierung", "fetaler", "Chromosomenanomalien", "und", "Verschlussstoerungen", "auf", "der", "Grundlage", "des", "muetterlichen", "Altersrisikos", "und", "der", "Serumparameter", "humanes", "Choriongonadotropin", "(", "hCG", ")", ",", "unkonjugiertes", "Oestriol", "(", "uE3", ")", "und", "Alpha", "-", "Fetoprotein", "(", "AFP", ")", "durchgefuehrt", ".", "Die", "prospektiv", "ermittelten", "Ergebnisse", "bestaetigen", "die", "Aussagen", "bisheriger", "retro-", "und", "prospektiver", "Studien", "zur", "Wertigkeit", "des", "sog", ".", "\"", "Triple", "-", "Tests", "\"", ".", "54", "fetale", "Chromosomenanomalien", "und", "27", "Verschlussstoerungen", "(", "Neural-", "und", "Bauchwanddefekte", ")", "wurden", "in", "diesem", "Patientenkollektiv", "unter", "Verwendung", "der", "in", "Deutschland", "ueblichen", "Grenzwerte", "erkannt", ".", "Es", "konnte", "festgestellt", "werden", ",", "dass", "ueber", "die", "eigentliche", "Zielgruppe", "hinaus", "regelmaessig", "weitere", "fetale", "und", "gestationsbezogene", "Stoerungen", "durch", "Extremwerte", "einzelner", "Serumparameter", "auffallen", "(", "z", ".", "B.", "intrauteriner", "Fruchttod", ",", "Hydrops", "fetalis", ",", "X", "-", "chromosomale", "Ichthyose", ")", ".", "Eigene", "Ergebnisse", "sowie", "Erkenntnisse", "zur", "Reduzierung", "systematischer", "Fehlerquellen", "und", "zur", "Verbesserung", "der", "Spezifitaet", "des", "Tests", "wurden", "gesammelt", "und", "sollen", "hier", "vorgestellt", "werden", "." ]	[ "umlsterm" ]
Humangenetik, Universitaet, Goettingen, Chromosomenanomalien, Oestriol, AFP, Chromosomenanomalien, Patientenkollektiv, Verwendung, Deutschland, gestationsbezogene, Fruchttod, Hydrops fetalis, X - chromosomale, Ichthyose, Spezifitaet	Reproduktionsmedizin.90150276.ger.abstr_task2	Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .	[ "Zwischen", "Ende", "1989", "und", "Anfang", "1999", "wurden", "am", "Institut", "fuer", "Humangenetik", "der", "Universitaet", "Goettingen", "33", "774", "routinemaessige", "Untersuchungen", "zur", "Risikospezifizierung", "fetaler", "Chromosomenanomalien", "und", "Verschlussstoerungen", "auf", "der", "Grundlage", "des", "muetterlichen", "Altersrisikos", "und", "der", "Serumparameter", "humanes", "Choriongonadotropin", "(", "hCG", ")", ",", "unkonjugiertes", "Oestriol", "(", "uE3", ")", "und", "Alpha", "-", "Fetoprotein", "(", "AFP", ")", "durchgefuehrt", ".", "Die", "prospektiv", "ermittelten", "Ergebnisse", "bestaetigen", "die", "Aussagen", "bisheriger", "retro-", "und", "prospektiver", "Studien", "zur", "Wertigkeit", "des", "sog", ".", "\"", "Triple", "-", "Tests", "\"", ".", "54", "fetale", "Chromosomenanomalien", "und", "27", "Verschlussstoerungen", "(", "Neural-", "und", "Bauchwanddefekte", ")", "wurden", "in", "diesem", "Patientenkollektiv", "unter", "Verwendung", "der", "in", "Deutschland", "ueblichen", "Grenzwerte", "erkannt", ".", "Es", "konnte", "festgestellt", "werden", ",", "dass", "ueber", "die", "eigentliche", "Zielgruppe", "hinaus", "regelmaessig", "weitere", "fetale", "und", "gestationsbezogene", "Stoerungen", "durch", "Extremwerte", "einzelner", "Serumparameter", "auffallen", "(", "z", ".", "B.", "intrauteriner", "Fruchttod", ",", "Hydrops", "fetalis", ",", "X", "-", "chromosomale", "Ichthyose", ")", ".", "Eigene", "Ergebnisse", "sowie", "Erkenntnisse", "zur", "Reduzierung", "systematischer", "Fehlerquellen", "und", "zur", "Verbesserung", "der", "Spezifitaet", "des", "Tests", "wurden", "gesammelt", "und", "sollen", "hier", "vorgestellt", "werden", "." ]	[ "umlsterm" ]
Laryngektomie is an umlsterm, Narbensegels is an umlsterm, Schleimhauttasche is an umlsterm, Zungengrund is an umlsterm, Arbeit is an umlsterm, Aetiologie is an umlsterm, Patienten is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Divertikelbildung is an umlsterm, Radiotherapie is an umlsterm, Wundheilung is an umlsterm, Narbenschwellen is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Laryngektomie is an umlsterm, radiologisch is an umlsterm, laserchirurgische is an umlsterm, Therapie is an umlsterm	HNO.80460060.ger.abstr_task0	Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .	[ "Beim", "anterioren", "Pseudodivertikel", "nach", "Laryngektomie", "handelt", "es", "sich", "um", "eine", "ventral", "eines", "queren", "Narbensegels", "liegende", "Schleimhauttasche", "zwischen", "Zungengrund", "und", "Hypopharynxtrichter", ".", "Das", "Krankheitsbild", "hat", "bisher", "wenig", "Beachtung", "gefunden", ".", "Die", "vorliegende", "Arbeit", "untersucht", ",", "wie", "haeufig", "Pseudodivertikel", "auftreten", ",", "wie", "oft", "sie", "Beschwerden", "verursachen", ",", "welche", "therapeutischen", "Moeglichkeiten", "bestehen", "und", "ob", "sich", "Aussagen", "zur", "Aetiologie", "machen", "lassen", ".", "Zu", "diesem", "Zweck", "wurden", "20", "laryngektomierte", "Patienten", "hinsichtlich", "Schluckbeschwerden", "befragt", "sowie", "klinisch", "und", "radiologisch", "auf", "das", "Vorliegen", "eines", "Pseudodivertikels", "untersucht", ".", "Bei", "11", "der", "20", "Patienten", "fand", "sich", "ein", "Pseudodivertikel", ",", "welches", "in", "9", "Faellen", "Schluckstoerungen", "verursachte", ".", "Ein", "Zusammenhang", "zwischen", "Divertikelbildung", "und", "Radiotherapie", "respektive", "Verlauf", "der", "Wundheilung", "konnte", "nicht", "nachgewiesen", "werden", ".", "Alle", "9", "symptomatischen", "Narbenschwellen", "wurden", "endoskopisch", "mittels", "CO2-Laser", "durchtrennt", ".", "Dadurch", "liessen", "sich", "8", "der", "9", "Patienten", "von", "ihren", "Schluckbeschwerden", "befreien", ".", "Das", "anteriore", "Pseudodivertikel", "ist", "eine", "haeufige", "Ursache", "von", "Schluckstoerungen", "nach", "Laryngektomie", ".", "Es", "ist", "klinisch", "und", "radiologisch", "einfach", "zu", "diagnostizieren", ".", "Die", "endoskopische", "laserchirurgische", "Schwellendurchtrennung", "ist", "eine", "einfache", "und", "effiziente", "Therapie", "." ]	[ "umlsterm" ]
Laryngektomie is an umlsterm, Narbensegels is an umlsterm, Schleimhauttasche is an umlsterm, Zungengrund is an umlsterm, Arbeit is an umlsterm, Aetiologie is an umlsterm, Patienten is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Divertikelbildung is an umlsterm, Radiotherapie is an umlsterm, Wundheilung is an umlsterm, Narbenschwellen is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Laryngektomie is an umlsterm, radiologisch is an umlsterm, laserchirurgische is an umlsterm, Therapie is an umlsterm	HNO.80460060.ger.abstr_task1	Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please typing these entity words according to sentence: Laryngektomie, Narbensegels, Schleimhauttasche, Zungengrund, Arbeit, Aetiologie, Patienten, radiologisch, Patienten, Schluckstoerungen, Divertikelbildung, Radiotherapie, Wundheilung, Narbenschwellen, Patienten, Schluckstoerungen, Laryngektomie, radiologisch, laserchirurgische, Therapie Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .	[ "Beim", "anterioren", "Pseudodivertikel", "nach", "Laryngektomie", "handelt", "es", "sich", "um", "eine", "ventral", "eines", "queren", "Narbensegels", "liegende", "Schleimhauttasche", "zwischen", "Zungengrund", "und", "Hypopharynxtrichter", ".", "Das", "Krankheitsbild", "hat", "bisher", "wenig", "Beachtung", "gefunden", ".", "Die", "vorliegende", "Arbeit", "untersucht", ",", "wie", "haeufig", "Pseudodivertikel", "auftreten", ",", "wie", "oft", "sie", "Beschwerden", "verursachen", ",", "welche", "therapeutischen", "Moeglichkeiten", "bestehen", "und", "ob", "sich", "Aussagen", "zur", "Aetiologie", "machen", "lassen", ".", "Zu", "diesem", "Zweck", "wurden", "20", "laryngektomierte", "Patienten", "hinsichtlich", "Schluckbeschwerden", "befragt", "sowie", "klinisch", "und", "radiologisch", "auf", "das", "Vorliegen", "eines", "Pseudodivertikels", "untersucht", ".", "Bei", "11", "der", "20", "Patienten", "fand", "sich", "ein", "Pseudodivertikel", ",", "welches", "in", "9", "Faellen", "Schluckstoerungen", "verursachte", ".", "Ein", "Zusammenhang", "zwischen", "Divertikelbildung", "und", "Radiotherapie", "respektive", "Verlauf", "der", "Wundheilung", "konnte", "nicht", "nachgewiesen", "werden", ".", "Alle", "9", "symptomatischen", "Narbenschwellen", "wurden", "endoskopisch", "mittels", "CO2-Laser", "durchtrennt", ".", "Dadurch", "liessen", "sich", "8", "der", "9", "Patienten", "von", "ihren", "Schluckbeschwerden", "befreien", ".", "Das", "anteriore", "Pseudodivertikel", "ist", "eine", "haeufige", "Ursache", "von", "Schluckstoerungen", "nach", "Laryngektomie", ".", "Es", "ist", "klinisch", "und", "radiologisch", "einfach", "zu", "diagnostizieren", ".", "Die", "endoskopische", "laserchirurgische", "Schwellendurchtrennung", "ist", "eine", "einfache", "und", "effiziente", "Therapie", "." ]	[ "umlsterm" ]
Laryngektomie, Narbensegels, Schleimhauttasche, Zungengrund, Arbeit, Aetiologie, Patienten, radiologisch, Patienten, Schluckstoerungen, Divertikelbildung, Radiotherapie, Wundheilung, Narbenschwellen, Patienten, Schluckstoerungen, Laryngektomie, radiologisch, laserchirurgische, Therapie	HNO.80460060.ger.abstr_task2	Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .	[ "Beim", "anterioren", "Pseudodivertikel", "nach", "Laryngektomie", "handelt", "es", "sich", "um", "eine", "ventral", "eines", "queren", "Narbensegels", "liegende", "Schleimhauttasche", "zwischen", "Zungengrund", "und", "Hypopharynxtrichter", ".", "Das", "Krankheitsbild", "hat", "bisher", "wenig", "Beachtung", "gefunden", ".", "Die", "vorliegende", "Arbeit", "untersucht", ",", "wie", "haeufig", "Pseudodivertikel", "auftreten", ",", "wie", "oft", "sie", "Beschwerden", "verursachen", ",", "welche", "therapeutischen", "Moeglichkeiten", "bestehen", "und", "ob", "sich", "Aussagen", "zur", "Aetiologie", "machen", "lassen", ".", "Zu", "diesem", "Zweck", "wurden", "20", "laryngektomierte", "Patienten", "hinsichtlich", "Schluckbeschwerden", "befragt", "sowie", "klinisch", "und", "radiologisch", "auf", "das", "Vorliegen", "eines", "Pseudodivertikels", "untersucht", ".", "Bei", "11", "der", "20", "Patienten", "fand", "sich", "ein", "Pseudodivertikel", ",", "welches", "in", "9", "Faellen", "Schluckstoerungen", "verursachte", ".", "Ein", "Zusammenhang", "zwischen", "Divertikelbildung", "und", "Radiotherapie", "respektive", "Verlauf", "der", "Wundheilung", "konnte", "nicht", "nachgewiesen", "werden", ".", "Alle", "9", "symptomatischen", "Narbenschwellen", "wurden", "endoskopisch", "mittels", "CO2-Laser", "durchtrennt", ".", "Dadurch", "liessen", "sich", "8", "der", "9", "Patienten", "von", "ihren", "Schluckbeschwerden", "befreien", ".", "Das", "anteriore", "Pseudodivertikel", "ist", "eine", "haeufige", "Ursache", "von", "Schluckstoerungen", "nach", "Laryngektomie", ".", "Es", "ist", "klinisch", "und", "radiologisch", "einfach", "zu", "diagnostizieren", ".", "Die", "endoskopische", "laserchirurgische", "Schwellendurchtrennung", "ist", "eine", "einfache", "und", "effiziente", "Therapie", "." ]	[ "umlsterm" ]
surgical is an umlsterm, treatment is an umlsterm, diverticulum is an umlsterm, diverticula is an umlsterm, complication is an umlsterm, procedure is an umlsterm, surgical is an umlsterm, operation is an umlsterm, diverticulum is an umlsterm, treatment is an umlsterm, choice is an umlsterm, stage is an umlsterm	DerChirurg.90700753.eng.abstr_task0	Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .	[ "The", "classical", "surgical", "approach", "for", "the", "treatment", "of", "Zenker", "'s", "diverticulum", "consists", "of", "diverticulectomy", "and", "cervical", "myotomy", ".", "In", "very", "small", "diverticula", "myotomy", "alone", "is", "sufficient", ".", "The", "complication", "rate", "of", "the", "procedure", "is", "tolerable", ".", "Long", "-", "term", "functional", "results", "are", "good", "in", "as", "much", "as", "90", "%", "and", "more", ".", "Despite", "the", "increasing", "importance", "of", "alternative", "approaches", ",", "the", "conventional", "extraluminal", "surgical", "operation", "for", "Zenker", "'s", "diverticulum", "will", "remain", "the", "treatment", "of", "choice", "in", "stage", "I", "-", "III", "cases", "." ]	[ "umlsterm" ]
surgical is an umlsterm, treatment is an umlsterm, diverticulum is an umlsterm, diverticula is an umlsterm, complication is an umlsterm, procedure is an umlsterm, surgical is an umlsterm, operation is an umlsterm, diverticulum is an umlsterm, treatment is an umlsterm, choice is an umlsterm, stage is an umlsterm	DerChirurg.90700753.eng.abstr_task1	Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please typing these entity words according to sentence: surgical, treatment, diverticulum, diverticula, complication, procedure, surgical, operation, diverticulum, treatment, choice, stage Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .	[ "The", "classical", "surgical", "approach", "for", "the", "treatment", "of", "Zenker", "'s", "diverticulum", "consists", "of", "diverticulectomy", "and", "cervical", "myotomy", ".", "In", "very", "small", "diverticula", "myotomy", "alone", "is", "sufficient", ".", "The", "complication", "rate", "of", "the", "procedure", "is", "tolerable", ".", "Long", "-", "term", "functional", "results", "are", "good", "in", "as", "much", "as", "90", "%", "and", "more", ".", "Despite", "the", "increasing", "importance", "of", "alternative", "approaches", ",", "the", "conventional", "extraluminal", "surgical", "operation", "for", "Zenker", "'s", "diverticulum", "will", "remain", "the", "treatment", "of", "choice", "in", "stage", "I", "-", "III", "cases", "." ]	[ "umlsterm" ]
surgical, treatment, diverticulum, diverticula, complication, procedure, surgical, operation, diverticulum, treatment, choice, stage	DerChirurg.90700753.eng.abstr_task2	Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .	[ "The", "classical", "surgical", "approach", "for", "the", "treatment", "of", "Zenker", "'s", "diverticulum", "consists", "of", "diverticulectomy", "and", "cervical", "myotomy", ".", "In", "very", "small", "diverticula", "myotomy", "alone", "is", "sufficient", ".", "The", "complication", "rate", "of", "the", "procedure", "is", "tolerable", ".", "Long", "-", "term", "functional", "results", "are", "good", "in", "as", "much", "as", "90", "%", "and", "more", ".", "Despite", "the", "increasing", "importance", "of", "alternative", "approaches", ",", "the", "conventional", "extraluminal", "surgical", "operation", "for", "Zenker", "'s", "diverticulum", "will", "remain", "the", "treatment", "of", "choice", "in", "stage", "I", "-", "III", "cases", "." ]	[ "umlsterm" ]
Hormonersatztherapie is an umlsterm, Therapiezeiten is an umlsterm, Risiko is an umlsterm, Therapie is an umlsterm, Mammakarzinoms is an umlsterm, Praxis is an umlsterm, Oestrogenentzugs is an umlsterm	DerGynaekologe.00330402.ger.abstr_task0	Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .	[ "Die", "Hormonersatztherapie", "(", "HRT", ")", "fuehrt", "bis", "zu", "einer", "Anwendungsdauer", "von", "5", "Jahren", "zu", "keiner", "Erhoehung", "des", "Mammakarzinomrisikos", ".", "Laengere", "Therapiezeiten", "erhoehen", "das", "Risiko", "geringgradig", ".", "Obwohl", "der", "Nutzen", "einer", "langfristigen", "HRT", "nach", "dem", "derzeitigen", "Kenntisstand", "ueberwiegt", ",", "muss", "dieser", "Faktor", "im", "Rahmen", "der", "Aufklaerung", "der", "Patientinnen", "beruecksichtigt", "werden", ".", "Nach", "der", "Therapie", "des", "Mammakarzinoms", "gilt", "die", "HRT", "als", "grundsaetzlich", "kontraindiziert", ".", "Im", "Individualfall", "kann", "sie", "jedoch", "nach", "Ausschoepffung", "der", "Alternativen", "eingesetzt", "werden", ".", "In", "der", "Praxis", "betrifft", "dies", "vorwiegend", "die", "Gruppe", "von", "Patientinnen", ",", "die", "massiv", "unter", "den", "vegetativen", "und", "vasomotorischen", "Symptomen", "des", "Oestrogenentzugs", "leiden", ".", "In", "dieser", "Situation", "sind", "nicht", "-", "hormonale", "Alternativen", "meist", "wenig", "wirksam", "." ]	[ "umlsterm" ]
Hormonersatztherapie is an umlsterm, Therapiezeiten is an umlsterm, Risiko is an umlsterm, Therapie is an umlsterm, Mammakarzinoms is an umlsterm, Praxis is an umlsterm, Oestrogenentzugs is an umlsterm	DerGynaekologe.00330402.ger.abstr_task1	Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please typing these entity words according to sentence: Hormonersatztherapie, Therapiezeiten, Risiko, Therapie, Mammakarzinoms, Praxis, Oestrogenentzugs Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .	[ "Die", "Hormonersatztherapie", "(", "HRT", ")", "fuehrt", "bis", "zu", "einer", "Anwendungsdauer", "von", "5", "Jahren", "zu", "keiner", "Erhoehung", "des", "Mammakarzinomrisikos", ".", "Laengere", "Therapiezeiten", "erhoehen", "das", "Risiko", "geringgradig", ".", "Obwohl", "der", "Nutzen", "einer", "langfristigen", "HRT", "nach", "dem", "derzeitigen", "Kenntisstand", "ueberwiegt", ",", "muss", "dieser", "Faktor", "im", "Rahmen", "der", "Aufklaerung", "der", "Patientinnen", "beruecksichtigt", "werden", ".", "Nach", "der", "Therapie", "des", "Mammakarzinoms", "gilt", "die", "HRT", "als", "grundsaetzlich", "kontraindiziert", ".", "Im", "Individualfall", "kann", "sie", "jedoch", "nach", "Ausschoepffung", "der", "Alternativen", "eingesetzt", "werden", ".", "In", "der", "Praxis", "betrifft", "dies", "vorwiegend", "die", "Gruppe", "von", "Patientinnen", ",", "die", "massiv", "unter", "den", "vegetativen", "und", "vasomotorischen", "Symptomen", "des", "Oestrogenentzugs", "leiden", ".", "In", "dieser", "Situation", "sind", "nicht", "-", "hormonale", "Alternativen", "meist", "wenig", "wirksam", "." ]	[ "umlsterm" ]
Hormonersatztherapie, Therapiezeiten, Risiko, Therapie, Mammakarzinoms, Praxis, Oestrogenentzugs	DerGynaekologe.00330402.ger.abstr_task2	Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .	[ "Die", "Hormonersatztherapie", "(", "HRT", ")", "fuehrt", "bis", "zu", "einer", "Anwendungsdauer", "von", "5", "Jahren", "zu", "keiner", "Erhoehung", "des", "Mammakarzinomrisikos", ".", "Laengere", "Therapiezeiten", "erhoehen", "das", "Risiko", "geringgradig", ".", "Obwohl", "der", "Nutzen", "einer", "langfristigen", "HRT", "nach", "dem", "derzeitigen", "Kenntisstand", "ueberwiegt", ",", "muss", "dieser", "Faktor", "im", "Rahmen", "der", "Aufklaerung", "der", "Patientinnen", "beruecksichtigt", "werden", ".", "Nach", "der", "Therapie", "des", "Mammakarzinoms", "gilt", "die", "HRT", "als", "grundsaetzlich", "kontraindiziert", ".", "Im", "Individualfall", "kann", "sie", "jedoch", "nach", "Ausschoepffung", "der", "Alternativen", "eingesetzt", "werden", ".", "In", "der", "Praxis", "betrifft", "dies", "vorwiegend", "die", "Gruppe", "von", "Patientinnen", ",", "die", "massiv", "unter", "den", "vegetativen", "und", "vasomotorischen", "Symptomen", "des", "Oestrogenentzugs", "leiden", ".", "In", "dieser", "Situation", "sind", "nicht", "-", "hormonale", "Alternativen", "meist", "wenig", "wirksam", "." ]	[ "umlsterm" ]
Rechtsmedizin is an umlsterm, Hochschule is an umlsterm, Berufsrecht is an umlsterm, Rechtsmedizin is an umlsterm, Rechtsmedizin is an umlsterm, Befragung is an umlsterm, Befragung is an umlsterm, Organisation is an umlsterm	Rechtsmedizin.00100182.ger.abstr_task0	Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .	[ "Der", "Kurs", "Rechtsmedizin", "an", "der", "Medizinischen", "Hochschule", "Hannover", "sah", "im", "Wintersemester", "1998/99", "fuer", "jeden", "Studierenden", "26", "Pflichtstunden", "vor", ".", "Er", "bestand", "aus", "mehreren", "2-stuendigen", "Seminaren", "und", "einer", "kursbegleitenden", "Vorlesung", ".", "Die", "Seminare", "hatten", "folgende", "Inhalte", ":", "Praktische", "Durchfuehrung", "einer", "Leichenschau", ",", "Teilnahme", "an", "einer", "Sektion", "mit", "Protokollerstellung", "und", "Nachbesprechung", ",", "Berufsrecht", "und", "-kunde", "sowie", "klinische", "Rechtsmedizin", "mit", "Verletzungsbegutachtung", ".", "Zusammen", "mit", "den", "zusaetzlichen", "Lehrangeboten", "umfasste", "die", "Lehre", "fuer", "das", "Fach", "Rechtsmedizin", "etwa", "15", "Semesterwochenstunden", ".", "Die", "Akzeptanz", "des", "Curriculums", "sollte", "durch", "eine", "Befragung", "der", "Studierenden", "ueberprueft", "werden", ".", "Von", "insgesamt", "361", "Studierenden", "beteiligten", "sich", "72", "%", "an", "der", "Befragung", ".", "Auf", "einer", "Notenskala", "von", "1", "-", "6", "wurde", "der", "Kurs", "insgesamt", "mit", "der", "Durchschnittsnote", "1,7", "bewertet", ".", "Auf", "einer", "Skala", "von", "1", "(", "=", "trifft", "nicht", "zu", ")", "bis", "7", "(", "=", "trifft", "zu", ")", "wurden", "Aussagen", "zu", "Struktur", "und", "Inhalt", "von", "Vorlesungen", "und", "Seminaren", "eingeordnet", ".", "Mit", "einer", "durchschnittlichen", "Bewertung", "von", "ueber", "6", "Punkten", "wurden", "logischer", "Aufbau", ",", "Organisation", ",", "Anschaulichkeit", "und", "interessante", "Darbietung", "des", "Stoffes", "bewertet", ".", "Auch", "fuer", "die", "kommenden", "Semester", "ist", "eine", "kontinuierliche", "Lehrevaluation", "vorgesehen", "." ]	[ "umlsterm" ]
Rechtsmedizin is an umlsterm, Hochschule is an umlsterm, Berufsrecht is an umlsterm, Rechtsmedizin is an umlsterm, Rechtsmedizin is an umlsterm, Befragung is an umlsterm, Befragung is an umlsterm, Organisation is an umlsterm	Rechtsmedizin.00100182.ger.abstr_task1	Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please typing these entity words according to sentence: Rechtsmedizin, Hochschule, Berufsrecht, Rechtsmedizin, Rechtsmedizin, Befragung, Befragung, Organisation Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .	[ "Der", "Kurs", "Rechtsmedizin", "an", "der", "Medizinischen", "Hochschule", "Hannover", "sah", "im", "Wintersemester", "1998/99", "fuer", "jeden", "Studierenden", "26", "Pflichtstunden", "vor", ".", "Er", "bestand", "aus", "mehreren", "2-stuendigen", "Seminaren", "und", "einer", "kursbegleitenden", "Vorlesung", ".", "Die", "Seminare", "hatten", "folgende", "Inhalte", ":", "Praktische", "Durchfuehrung", "einer", "Leichenschau", ",", "Teilnahme", "an", "einer", "Sektion", "mit", "Protokollerstellung", "und", "Nachbesprechung", ",", "Berufsrecht", "und", "-kunde", "sowie", "klinische", "Rechtsmedizin", "mit", "Verletzungsbegutachtung", ".", "Zusammen", "mit", "den", "zusaetzlichen", "Lehrangeboten", "umfasste", "die", "Lehre", "fuer", "das", "Fach", "Rechtsmedizin", "etwa", "15", "Semesterwochenstunden", ".", "Die", "Akzeptanz", "des", "Curriculums", "sollte", "durch", "eine", "Befragung", "der", "Studierenden", "ueberprueft", "werden", ".", "Von", "insgesamt", "361", "Studierenden", "beteiligten", "sich", "72", "%", "an", "der", "Befragung", ".", "Auf", "einer", "Notenskala", "von", "1", "-", "6", "wurde", "der", "Kurs", "insgesamt", "mit", "der", "Durchschnittsnote", "1,7", "bewertet", ".", "Auf", "einer", "Skala", "von", "1", "(", "=", "trifft", "nicht", "zu", ")", "bis", "7", "(", "=", "trifft", "zu", ")", "wurden", "Aussagen", "zu", "Struktur", "und", "Inhalt", "von", "Vorlesungen", "und", "Seminaren", "eingeordnet", ".", "Mit", "einer", "durchschnittlichen", "Bewertung", "von", "ueber", "6", "Punkten", "wurden", "logischer", "Aufbau", ",", "Organisation", ",", "Anschaulichkeit", "und", "interessante", "Darbietung", "des", "Stoffes", "bewertet", ".", "Auch", "fuer", "die", "kommenden", "Semester", "ist", "eine", "kontinuierliche", "Lehrevaluation", "vorgesehen", "." ]	[ "umlsterm" ]
Rechtsmedizin, Hochschule, Berufsrecht, Rechtsmedizin, Rechtsmedizin, Befragung, Befragung, Organisation	Rechtsmedizin.00100182.ger.abstr_task2	Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .	[ "Der", "Kurs", "Rechtsmedizin", "an", "der", "Medizinischen", "Hochschule", "Hannover", "sah", "im", "Wintersemester", "1998/99", "fuer", "jeden", "Studierenden", "26", "Pflichtstunden", "vor", ".", "Er", "bestand", "aus", "mehreren", "2-stuendigen", "Seminaren", "und", "einer", "kursbegleitenden", "Vorlesung", ".", "Die", "Seminare", "hatten", "folgende", "Inhalte", ":", "Praktische", "Durchfuehrung", "einer", "Leichenschau", ",", "Teilnahme", "an", "einer", "Sektion", "mit", "Protokollerstellung", "und", "Nachbesprechung", ",", "Berufsrecht", "und", "-kunde", "sowie", "klinische", "Rechtsmedizin", "mit", "Verletzungsbegutachtung", ".", "Zusammen", "mit", "den", "zusaetzlichen", "Lehrangeboten", "umfasste", "die", "Lehre", "fuer", "das", "Fach", "Rechtsmedizin", "etwa", "15", "Semesterwochenstunden", ".", "Die", "Akzeptanz", "des", "Curriculums", "sollte", "durch", "eine", "Befragung", "der", "Studierenden", "ueberprueft", "werden", ".", "Von", "insgesamt", "361", "Studierenden", "beteiligten", "sich", "72", "%", "an", "der", "Befragung", ".", "Auf", "einer", "Notenskala", "von", "1", "-", "6", "wurde", "der", "Kurs", "insgesamt", "mit", "der", "Durchschnittsnote", "1,7", "bewertet", ".", "Auf", "einer", "Skala", "von", "1", "(", "=", "trifft", "nicht", "zu", ")", "bis", "7", "(", "=", "trifft", "zu", ")", "wurden", "Aussagen", "zu", "Struktur", "und", "Inhalt", "von", "Vorlesungen", "und", "Seminaren", "eingeordnet", ".", "Mit", "einer", "durchschnittlichen", "Bewertung", "von", "ueber", "6", "Punkten", "wurden", "logischer", "Aufbau", ",", "Organisation", ",", "Anschaulichkeit", "und", "interessante", "Darbietung", "des", "Stoffes", "bewertet", ".", "Auch", "fuer", "die", "kommenden", "Semester", "ist", "eine", "kontinuierliche", "Lehrevaluation", "vorgesehen", "." ]	[ "umlsterm" ]
Kopf - Hals - Tumoren is an umlsterm, Erweiterung is an umlsterm, Patienten is an umlsterm, Karzinomen is an umlsterm, Hypopharynx is an umlsterm, Larynx is an umlsterm, Speicheldruesen is an umlsterm, Klassifikation is an umlsterm, Tumoren is an umlsterm, Speicheldruesen is an umlsterm, rezidivfreien is an umlsterm, Eignung is an umlsterm, Prognoseunterschied is an umlsterm	HNO.90470957.ger.abstr_task0	Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .	[ "Zusammenfassung", "Die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "bringt", "einige", "Aenderungen", "im", "Bereich", "der", "Kopf", "-", "Hals", "-", "Tumoren", "mit", "sich", ".", "Eine", "wesentliche", "Erweiterung", "der", "Stadiengruppierung", "besteht", "in", "der", "Unterteilung", "von", "Stadium", "IV", "in", "3", "Unterstadien", ".", "In", "einer", "retrospektiven", "Studie", "wurden", "die", "Krankheitsverlaeufe", "von", "3247", "Patienten", "mit", "Karzinomen", "der", "Mundhoehle", ",", "des", "Oro-", "und", "Hypopharynx", ",", "des", "Larynx", ",", "der", "Speicheldruesen", "und", "der", "Kieferhoehle", "ausgewertet", ".", "Hierbei", "kamen", "die", "4", ".", "und", "die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "vergleichend", "zur", "Anwendung", ".", "Insbesondere", "wurde", "geprueft", ",", "ob", "der", "Unterteilung", "von", "Stadium", "IV", "eine", "prognostische", "Relevanz", "zukommt", ".", "Bei", "der", "Klassifikation", "des", "Primaertumors", "ergaben", "sich", "die", "umfassendsten", "Aenderungen", "bei", "Tumoren", "der", "Supraglottis", "und", "der", "Speicheldruesen", ".", "Nach", "der", "4", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "errechneten", "sich", "folgende", "rezidivfreien", "Fuenfjahresueberlebensraten", ":", "Stadium", "I", "89,7", "%", ",", "Stadium", "II", "78,9", "%", ",", "Stadium", "III", "60,3", "%", ",", "Stadium", "IV", "31,0", "%", ",", "nach", "der", "5", ".", "Aufl", ".", ":", "Stadium", "I", "90,8", "%", ",", "Stadium", "II", "77,1", "%", ",", "Stadium", "III", "61,3", "%", ",", "Stadium", "IVA", "32,2", "%", ",", "Stadium", "IVB", "25,8", "%", ",", "Stadium", "IVC", "7,9", "%", ".", "Die", "Eignung", "der", "neuen", "Stadieneinteilung", "zur", "Schaffung", "einer", "prognostische", "Hierarchie", "konnte", "bestaetigt", "werden", ".", "Allerdings", "liess", "sich", "kein", "signifikanter", "Prognoseunterschied", "zwischen", "einer", "N2-", "(", "Stadium", "IVA", ")", "und", "einer", "N3-Metastasierung", "(", "Stadium", "IVB", ")", "finden", "." ]	[ "umlsterm" ]
Kopf - Hals - Tumoren is an umlsterm, Erweiterung is an umlsterm, Patienten is an umlsterm, Karzinomen is an umlsterm, Hypopharynx is an umlsterm, Larynx is an umlsterm, Speicheldruesen is an umlsterm, Klassifikation is an umlsterm, Tumoren is an umlsterm, Speicheldruesen is an umlsterm, rezidivfreien is an umlsterm, Eignung is an umlsterm, Prognoseunterschied is an umlsterm	HNO.90470957.ger.abstr_task1	Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please typing these entity words according to sentence: Kopf - Hals - Tumoren, Erweiterung, Patienten, Karzinomen, Hypopharynx, Larynx, Speicheldruesen, Klassifikation, Tumoren, Speicheldruesen, rezidivfreien, Eignung, Prognoseunterschied Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .	[ "Zusammenfassung", "Die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "bringt", "einige", "Aenderungen", "im", "Bereich", "der", "Kopf", "-", "Hals", "-", "Tumoren", "mit", "sich", ".", "Eine", "wesentliche", "Erweiterung", "der", "Stadiengruppierung", "besteht", "in", "der", "Unterteilung", "von", "Stadium", "IV", "in", "3", "Unterstadien", ".", "In", "einer", "retrospektiven", "Studie", "wurden", "die", "Krankheitsverlaeufe", "von", "3247", "Patienten", "mit", "Karzinomen", "der", "Mundhoehle", ",", "des", "Oro-", "und", "Hypopharynx", ",", "des", "Larynx", ",", "der", "Speicheldruesen", "und", "der", "Kieferhoehle", "ausgewertet", ".", "Hierbei", "kamen", "die", "4", ".", "und", "die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "vergleichend", "zur", "Anwendung", ".", "Insbesondere", "wurde", "geprueft", ",", "ob", "der", "Unterteilung", "von", "Stadium", "IV", "eine", "prognostische", "Relevanz", "zukommt", ".", "Bei", "der", "Klassifikation", "des", "Primaertumors", "ergaben", "sich", "die", "umfassendsten", "Aenderungen", "bei", "Tumoren", "der", "Supraglottis", "und", "der", "Speicheldruesen", ".", "Nach", "der", "4", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "errechneten", "sich", "folgende", "rezidivfreien", "Fuenfjahresueberlebensraten", ":", "Stadium", "I", "89,7", "%", ",", "Stadium", "II", "78,9", "%", ",", "Stadium", "III", "60,3", "%", ",", "Stadium", "IV", "31,0", "%", ",", "nach", "der", "5", ".", "Aufl", ".", ":", "Stadium", "I", "90,8", "%", ",", "Stadium", "II", "77,1", "%", ",", "Stadium", "III", "61,3", "%", ",", "Stadium", "IVA", "32,2", "%", ",", "Stadium", "IVB", "25,8", "%", ",", "Stadium", "IVC", "7,9", "%", ".", "Die", "Eignung", "der", "neuen", "Stadieneinteilung", "zur", "Schaffung", "einer", "prognostische", "Hierarchie", "konnte", "bestaetigt", "werden", ".", "Allerdings", "liess", "sich", "kein", "signifikanter", "Prognoseunterschied", "zwischen", "einer", "N2-", "(", "Stadium", "IVA", ")", "und", "einer", "N3-Metastasierung", "(", "Stadium", "IVB", ")", "finden", "." ]	[ "umlsterm" ]
Kopf - Hals - Tumoren, Erweiterung, Patienten, Karzinomen, Hypopharynx, Larynx, Speicheldruesen, Klassifikation, Tumoren, Speicheldruesen, rezidivfreien, Eignung, Prognoseunterschied	HNO.90470957.ger.abstr_task2	Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .	[ "Zusammenfassung", "Die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "bringt", "einige", "Aenderungen", "im", "Bereich", "der", "Kopf", "-", "Hals", "-", "Tumoren", "mit", "sich", ".", "Eine", "wesentliche", "Erweiterung", "der", "Stadiengruppierung", "besteht", "in", "der", "Unterteilung", "von", "Stadium", "IV", "in", "3", "Unterstadien", ".", "In", "einer", "retrospektiven", "Studie", "wurden", "die", "Krankheitsverlaeufe", "von", "3247", "Patienten", "mit", "Karzinomen", "der", "Mundhoehle", ",", "des", "Oro-", "und", "Hypopharynx", ",", "des", "Larynx", ",", "der", "Speicheldruesen", "und", "der", "Kieferhoehle", "ausgewertet", ".", "Hierbei", "kamen", "die", "4", ".", "und", "die", "5", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "vergleichend", "zur", "Anwendung", ".", "Insbesondere", "wurde", "geprueft", ",", "ob", "der", "Unterteilung", "von", "Stadium", "IV", "eine", "prognostische", "Relevanz", "zukommt", ".", "Bei", "der", "Klassifikation", "des", "Primaertumors", "ergaben", "sich", "die", "umfassendsten", "Aenderungen", "bei", "Tumoren", "der", "Supraglottis", "und", "der", "Speicheldruesen", ".", "Nach", "der", "4", ".", "Aufl", ".", "der", "TNM", "-", "Klassifikation", "errechneten", "sich", "folgende", "rezidivfreien", "Fuenfjahresueberlebensraten", ":", "Stadium", "I", "89,7", "%", ",", "Stadium", "II", "78,9", "%", ",", "Stadium", "III", "60,3", "%", ",", "Stadium", "IV", "31,0", "%", ",", "nach", "der", "5", ".", "Aufl", ".", ":", "Stadium", "I", "90,8", "%", ",", "Stadium", "II", "77,1", "%", ",", "Stadium", "III", "61,3", "%", ",", "Stadium", "IVA", "32,2", "%", ",", "Stadium", "IVB", "25,8", "%", ",", "Stadium", "IVC", "7,9", "%", ".", "Die", "Eignung", "der", "neuen", "Stadieneinteilung", "zur", "Schaffung", "einer", "prognostische", "Hierarchie", "konnte", "bestaetigt", "werden", ".", "Allerdings", "liess", "sich", "kein", "signifikanter", "Prognoseunterschied", "zwischen", "einer", "N2-", "(", "Stadium", "IVA", ")", "und", "einer", "N3-Metastasierung", "(", "Stadium", "IVB", ")", "finden", "." ]	[ "umlsterm" ]
c - Jun N - terminal kinase is a Individual_protein, stress - activated protein kinase is a Individual_protein, JNK is a Individual_protein, SAPK is a Individual_protein, AP-1 is a Gene/protein/RNA	412_task0	Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]	In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.	[ "In", "addition", ",", "we", "report", "that", "radiation", "induced", "transient", "activation", "of", "c", "-", "Jun", "N", "-", "terminal", "kinase", "/", "stress", "-", "activated", "protein", "kinase", "(", "JNK", "/", "SAPK", ")", "activation", "and", "the", "transcription", "factor", ",", "AP-1", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
c - Jun N - terminal kinase is a Individual_protein, stress - activated protein kinase is a Individual_protein, JNK is a Individual_protein, SAPK is a Individual_protein, AP-1 is a Gene/protein/RNA	412_task1	Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please typing these entity words according to sentence: c - Jun N - terminal kinase, stress - activated protein kinase, JNK, SAPK, AP-1 Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]	In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.	[ "In", "addition", ",", "we", "report", "that", "radiation", "induced", "transient", "activation", "of", "c", "-", "Jun", "N", "-", "terminal", "kinase", "/", "stress", "-", "activated", "protein", "kinase", "(", "JNK", "/", "SAPK", ")", "activation", "and", "the", "transcription", "factor", ",", "AP-1", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
c - Jun N - terminal kinase, stress - activated protein kinase, JNK, SAPK, AP-1	412_task2	Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]	In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.	[ "In", "addition", ",", "we", "report", "that", "radiation", "induced", "transient", "activation", "of", "c", "-", "Jun", "N", "-", "terminal", "kinase", "/", "stress", "-", "activated", "protein", "kinase", "(", "JNK", "/", "SAPK", ")", "activation", "and", "the", "transcription", "factor", ",", "AP-1", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
heart is an umlsterm, epidemiological studies is an umlsterm, clinical trials is an umlsterm	ZfuerKardiologie.90880014.eng.abstr_task0	Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .	[ "Background", ":", "Prognostic", "data", "heart", "failure", "rely", "on", "epidemiological", "studies", "or", "large", "clinical", "trials", ".", "These", "data", "are", "not", "to", "transfer", "easily", "on", "everyday", "practice", "." ]	[ "umlsterm" ]
heart is an umlsterm, epidemiological studies is an umlsterm, clinical trials is an umlsterm	ZfuerKardiologie.90880014.eng.abstr_task1	Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please typing these entity words according to sentence: heart, epidemiological studies, clinical trials Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .	[ "Background", ":", "Prognostic", "data", "heart", "failure", "rely", "on", "epidemiological", "studies", "or", "large", "clinical", "trials", ".", "These", "data", "are", "not", "to", "transfer", "easily", "on", "everyday", "practice", "." ]	[ "umlsterm" ]
heart, epidemiological studies, clinical trials	ZfuerKardiologie.90880014.eng.abstr_task2	Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .	[ "Background", ":", "Prognostic", "data", "heart", "failure", "rely", "on", "epidemiological", "studies", "or", "large", "clinical", "trials", ".", "These", "data", "are", "not", "to", "transfer", "easily", "on", "everyday", "practice", "." ]	[ "umlsterm" ]
Sprunggelenks is an umlsterm, Patienten is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, radiologischen is an umlsterm, Hauptdiagnose is an umlsterm, chronische Polyarthritis is an umlsterm, weiblichen is an umlsterm, Geschlechts is an umlsterm, STAR - Prothesen is an umlsterm, Roentgenanalyse is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, Prothesenlockerung is an umlsterm, Patient is an umlsterm, STAR - Prothesen is an umlsterm	DerOrthopaede.80270183.ger.abstr_task0	Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .	[ "Es", "werden", "die", "mittelfristigen", "Ergebnisse", "nach", "prothetischer", "Versorgung", "des", "Sprunggelenks", "vorgestellt", ";", "37", "Patienten", "mit", "jeweils", "20", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", "und", "19", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "konnten", "zwischen", "1", "und", "12", "Jahren", "postoperativ", "nachuntersucht", "werden", ".", "Die", "Nachuntersuchung", "basiert", "auf", "dem", "Kofoed", "-", "ankle", "-", "Score", "einschliesslich", "einer", "radiologischen", "Verlaufskontrolle", ".", "Die", "Hauptdiagnose", "war", "in", "beiden", "Kollektiven", "eine", "chronische", "Polyarthritis", "mit", "Dominanz", "des", "weiblichen", "Geschlechts", ".", "Zum", "Zeitpunkt", "der", "aktuellen", "Nachuntersuchung", "verbesserte", "sich", "der", "Gesamtscore", "fuer", "die", "STAR", "-", "Prothesen", "auf", "durchschnittlich", "86,2", "Punkte", "und", "fuer", "die", "Thompson", "-", "Richards", "-", "Prothesen", "auf", "77,7", "Punkte", ".", "Dies", "entspricht", "zu", "94,7", "bzw", ".", "75", "%", "einem", "guten", "bis", "sehr", "guten", "Gesamtergebnis", ".", "Die", "Roentgenanalyse", "zeigte", "einen", "hohen", "Prozentsatz", "an", "radiolucent", "lines", "\"", "\"", "insbesondere", "der", "tibialen", "Komponente", "der", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", ",", "bei", "einer", "revisionspflichtigen", "Lockerungsrate", "von", "7,4", "%", ".", "Die", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "weisen", "lediglich", "in", "15,8", "%", "schmale", "\"", "radiolucent", "lines", "\"", "der", "tibialen", "Komponente", "auf", ".", "Eine", "Lockerung", "wurde", "nicht", "beobachtet", ";", "2", "Thompson", "-", "Richards", "-", "Prothesen", "mussten", "aufgrund", "einer", "Prothesenlockerung", "revidiert", "werden", ".", "Zusaetzlich", "zog", "sich", "ein", "Patient", "postoperativ", "eine", "osteosynthesepflichtige", "Weber", "-", "C", "-", "Fraktur", "zu", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "12", "Jahren", "betrug", "87", "%", ".", "Im", "Kollektiv", "der", "STAR", "-", "Prothesen", "wurden", "2", "Revisionen", "des", "Gleitkerns", "notwendig", "aufgrund", "eines", "Gleitkernbruchs", "bzw", ".", "einer", "primaer", "zu", "niedrig", "gewaehlten", "Gleitkernhoehe", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "6", "Jahren", "betraegt", "94,3", "%", "." ]	[ "umlsterm" ]
Sprunggelenks is an umlsterm, Patienten is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, radiologischen is an umlsterm, Hauptdiagnose is an umlsterm, chronische Polyarthritis is an umlsterm, weiblichen is an umlsterm, Geschlechts is an umlsterm, STAR - Prothesen is an umlsterm, Roentgenanalyse is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, Prothesenlockerung is an umlsterm, Patient is an umlsterm, STAR - Prothesen is an umlsterm	DerOrthopaede.80270183.ger.abstr_task1	Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please typing these entity words according to sentence: Sprunggelenks, Patienten, zementfrei, STAR - Prothesen, radiologischen, Hauptdiagnose, chronische Polyarthritis, weiblichen, Geschlechts, STAR - Prothesen, Roentgenanalyse, zementfrei, STAR - Prothesen, Prothesenlockerung, Patient, STAR - Prothesen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .	[ "Es", "werden", "die", "mittelfristigen", "Ergebnisse", "nach", "prothetischer", "Versorgung", "des", "Sprunggelenks", "vorgestellt", ";", "37", "Patienten", "mit", "jeweils", "20", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", "und", "19", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "konnten", "zwischen", "1", "und", "12", "Jahren", "postoperativ", "nachuntersucht", "werden", ".", "Die", "Nachuntersuchung", "basiert", "auf", "dem", "Kofoed", "-", "ankle", "-", "Score", "einschliesslich", "einer", "radiologischen", "Verlaufskontrolle", ".", "Die", "Hauptdiagnose", "war", "in", "beiden", "Kollektiven", "eine", "chronische", "Polyarthritis", "mit", "Dominanz", "des", "weiblichen", "Geschlechts", ".", "Zum", "Zeitpunkt", "der", "aktuellen", "Nachuntersuchung", "verbesserte", "sich", "der", "Gesamtscore", "fuer", "die", "STAR", "-", "Prothesen", "auf", "durchschnittlich", "86,2", "Punkte", "und", "fuer", "die", "Thompson", "-", "Richards", "-", "Prothesen", "auf", "77,7", "Punkte", ".", "Dies", "entspricht", "zu", "94,7", "bzw", ".", "75", "%", "einem", "guten", "bis", "sehr", "guten", "Gesamtergebnis", ".", "Die", "Roentgenanalyse", "zeigte", "einen", "hohen", "Prozentsatz", "an", "radiolucent", "lines", "\"", "\"", "insbesondere", "der", "tibialen", "Komponente", "der", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", ",", "bei", "einer", "revisionspflichtigen", "Lockerungsrate", "von", "7,4", "%", ".", "Die", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "weisen", "lediglich", "in", "15,8", "%", "schmale", "\"", "radiolucent", "lines", "\"", "der", "tibialen", "Komponente", "auf", ".", "Eine", "Lockerung", "wurde", "nicht", "beobachtet", ";", "2", "Thompson", "-", "Richards", "-", "Prothesen", "mussten", "aufgrund", "einer", "Prothesenlockerung", "revidiert", "werden", ".", "Zusaetzlich", "zog", "sich", "ein", "Patient", "postoperativ", "eine", "osteosynthesepflichtige", "Weber", "-", "C", "-", "Fraktur", "zu", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "12", "Jahren", "betrug", "87", "%", ".", "Im", "Kollektiv", "der", "STAR", "-", "Prothesen", "wurden", "2", "Revisionen", "des", "Gleitkerns", "notwendig", "aufgrund", "eines", "Gleitkernbruchs", "bzw", ".", "einer", "primaer", "zu", "niedrig", "gewaehlten", "Gleitkernhoehe", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "6", "Jahren", "betraegt", "94,3", "%", "." ]	[ "umlsterm" ]
Sprunggelenks, Patienten, zementfrei, STAR - Prothesen, radiologischen, Hauptdiagnose, chronische Polyarthritis, weiblichen, Geschlechts, STAR - Prothesen, Roentgenanalyse, zementfrei, STAR - Prothesen, Prothesenlockerung, Patient, STAR - Prothesen	DerOrthopaede.80270183.ger.abstr_task2	Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .	[ "Es", "werden", "die", "mittelfristigen", "Ergebnisse", "nach", "prothetischer", "Versorgung", "des", "Sprunggelenks", "vorgestellt", ";", "37", "Patienten", "mit", "jeweils", "20", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", "und", "19", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "konnten", "zwischen", "1", "und", "12", "Jahren", "postoperativ", "nachuntersucht", "werden", ".", "Die", "Nachuntersuchung", "basiert", "auf", "dem", "Kofoed", "-", "ankle", "-", "Score", "einschliesslich", "einer", "radiologischen", "Verlaufskontrolle", ".", "Die", "Hauptdiagnose", "war", "in", "beiden", "Kollektiven", "eine", "chronische", "Polyarthritis", "mit", "Dominanz", "des", "weiblichen", "Geschlechts", ".", "Zum", "Zeitpunkt", "der", "aktuellen", "Nachuntersuchung", "verbesserte", "sich", "der", "Gesamtscore", "fuer", "die", "STAR", "-", "Prothesen", "auf", "durchschnittlich", "86,2", "Punkte", "und", "fuer", "die", "Thompson", "-", "Richards", "-", "Prothesen", "auf", "77,7", "Punkte", ".", "Dies", "entspricht", "zu", "94,7", "bzw", ".", "75", "%", "einem", "guten", "bis", "sehr", "guten", "Gesamtergebnis", ".", "Die", "Roentgenanalyse", "zeigte", "einen", "hohen", "Prozentsatz", "an", "radiolucent", "lines", "\"", "\"", "insbesondere", "der", "tibialen", "Komponente", "der", "zementiert", "verankerten", "Thompson", "-", "Richards", "-", "Prothesen", ",", "bei", "einer", "revisionspflichtigen", "Lockerungsrate", "von", "7,4", "%", ".", "Die", "zementfrei", "implantierten", "STAR", "-", "Prothesen", "weisen", "lediglich", "in", "15,8", "%", "schmale", "\"", "radiolucent", "lines", "\"", "der", "tibialen", "Komponente", "auf", ".", "Eine", "Lockerung", "wurde", "nicht", "beobachtet", ";", "2", "Thompson", "-", "Richards", "-", "Prothesen", "mussten", "aufgrund", "einer", "Prothesenlockerung", "revidiert", "werden", ".", "Zusaetzlich", "zog", "sich", "ein", "Patient", "postoperativ", "eine", "osteosynthesepflichtige", "Weber", "-", "C", "-", "Fraktur", "zu", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "12", "Jahren", "betrug", "87", "%", ".", "Im", "Kollektiv", "der", "STAR", "-", "Prothesen", "wurden", "2", "Revisionen", "des", "Gleitkerns", "notwendig", "aufgrund", "eines", "Gleitkernbruchs", "bzw", ".", "einer", "primaer", "zu", "niedrig", "gewaehlten", "Gleitkernhoehe", ".", "Die", "kumulative", "Ueberlebensrate", "nach", "6", "Jahren", "betraegt", "94,3", "%", "." ]	[ "umlsterm" ]
Zytokine is an umlsterm, Glukokortikoide is an umlsterm, Immunzellen is an umlsterm, Zellen is an umlsterm, Rolle is an umlsterm, Immunzellen is an umlsterm, Antigenen is an umlsterm	ZfuerRheumatologie.0059ii26.ger.abstr_task0	Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .	[ "Wegen", "ihrer", "anti", "-", "inflammatorischen", "Effekte", "und", "ihrer", "Potenz", ",", "die", "Synthese", "der", "meisten", "Zytokine", "und", "die", "Balance", "Th1", "/", "Th2", "zu", "beeinflussen", ",", "tragen", "die", "endogenen", "Glukokortikoide", "zur", "basalen", "Regulation", "der", "Immunzellen", "bei", ".", "Immunologische", "Prozesse", "verursachen", "die", "Produktion", "von", "Zytokinen", ",", "wie", "IL-1", ",", "IL-2", ",", "IL-6", ",", "IL-11", ",", "IL-12", ",", "TNF-", ",", "INF-", ",", "welche", "ihrerseits", "die", "HPA", "Achse", "stimulieren", "koennen", ".", "Der", "dadurch", "vermittelte", "Anstieg", "von", "Glukokortikoiden", "wirkt", "entweder", "direkt", "oder", "ueber", "die", "Beeinflussung", "der", "Produktion", "von", "Zytokinen", "auf", "immunologische", "Zellen", ",", "was", "die", "Existenz", "eines", "zytokinvermittelten", "immunregulatorischen", "Regelkreises", "mit", "der", "HPA", "Achse", "nahelegt", ".", "Es", "gilt", "als", "gesichert", ",", "dass", "dieser", "Regelkreis", "eine", "bedeutsame", "Rolle", "spielt", "bei", "der", "Kontrolle", "einer", "ueberschiessenden", "Immunantwort", "und", "der", "Unterdrueckung", "der", "Expansion", "von", "Immunzellen", "mit", "fehlender", "oder", "nur", "geringer", "Affinitaet", "zu", "Antigenen", ",", "welche", "die", "spezifische", "Immunantwort", "ausloesen", "." ]	[ "umlsterm" ]
Zytokine is an umlsterm, Glukokortikoide is an umlsterm, Immunzellen is an umlsterm, Zellen is an umlsterm, Rolle is an umlsterm, Immunzellen is an umlsterm, Antigenen is an umlsterm	ZfuerRheumatologie.0059ii26.ger.abstr_task1	Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please typing these entity words according to sentence: Zytokine, Glukokortikoide, Immunzellen, Zellen, Rolle, Immunzellen, Antigenen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .	[ "Wegen", "ihrer", "anti", "-", "inflammatorischen", "Effekte", "und", "ihrer", "Potenz", ",", "die", "Synthese", "der", "meisten", "Zytokine", "und", "die", "Balance", "Th1", "/", "Th2", "zu", "beeinflussen", ",", "tragen", "die", "endogenen", "Glukokortikoide", "zur", "basalen", "Regulation", "der", "Immunzellen", "bei", ".", "Immunologische", "Prozesse", "verursachen", "die", "Produktion", "von", "Zytokinen", ",", "wie", "IL-1", ",", "IL-2", ",", "IL-6", ",", "IL-11", ",", "IL-12", ",", "TNF-", ",", "INF-", ",", "welche", "ihrerseits", "die", "HPA", "Achse", "stimulieren", "koennen", ".", "Der", "dadurch", "vermittelte", "Anstieg", "von", "Glukokortikoiden", "wirkt", "entweder", "direkt", "oder", "ueber", "die", "Beeinflussung", "der", "Produktion", "von", "Zytokinen", "auf", "immunologische", "Zellen", ",", "was", "die", "Existenz", "eines", "zytokinvermittelten", "immunregulatorischen", "Regelkreises", "mit", "der", "HPA", "Achse", "nahelegt", ".", "Es", "gilt", "als", "gesichert", ",", "dass", "dieser", "Regelkreis", "eine", "bedeutsame", "Rolle", "spielt", "bei", "der", "Kontrolle", "einer", "ueberschiessenden", "Immunantwort", "und", "der", "Unterdrueckung", "der", "Expansion", "von", "Immunzellen", "mit", "fehlender", "oder", "nur", "geringer", "Affinitaet", "zu", "Antigenen", ",", "welche", "die", "spezifische", "Immunantwort", "ausloesen", "." ]	[ "umlsterm" ]
Zytokine, Glukokortikoide, Immunzellen, Zellen, Rolle, Immunzellen, Antigenen	ZfuerRheumatologie.0059ii26.ger.abstr_task2	Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .	[ "Wegen", "ihrer", "anti", "-", "inflammatorischen", "Effekte", "und", "ihrer", "Potenz", ",", "die", "Synthese", "der", "meisten", "Zytokine", "und", "die", "Balance", "Th1", "/", "Th2", "zu", "beeinflussen", ",", "tragen", "die", "endogenen", "Glukokortikoide", "zur", "basalen", "Regulation", "der", "Immunzellen", "bei", ".", "Immunologische", "Prozesse", "verursachen", "die", "Produktion", "von", "Zytokinen", ",", "wie", "IL-1", ",", "IL-2", ",", "IL-6", ",", "IL-11", ",", "IL-12", ",", "TNF-", ",", "INF-", ",", "welche", "ihrerseits", "die", "HPA", "Achse", "stimulieren", "koennen", ".", "Der", "dadurch", "vermittelte", "Anstieg", "von", "Glukokortikoiden", "wirkt", "entweder", "direkt", "oder", "ueber", "die", "Beeinflussung", "der", "Produktion", "von", "Zytokinen", "auf", "immunologische", "Zellen", ",", "was", "die", "Existenz", "eines", "zytokinvermittelten", "immunregulatorischen", "Regelkreises", "mit", "der", "HPA", "Achse", "nahelegt", ".", "Es", "gilt", "als", "gesichert", ",", "dass", "dieser", "Regelkreis", "eine", "bedeutsame", "Rolle", "spielt", "bei", "der", "Kontrolle", "einer", "ueberschiessenden", "Immunantwort", "und", "der", "Unterdrueckung", "der", "Expansion", "von", "Immunzellen", "mit", "fehlender", "oder", "nur", "geringer", "Affinitaet", "zu", "Antigenen", ",", "welche", "die", "spezifische", "Immunantwort", "ausloesen", "." ]	[ "umlsterm" ]
Classification systems is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, urodynamic is an umlsterm, classification is an umlsterm, function is an umlsterm, behaviour is an umlsterm, bladder is an umlsterm, bladder is an umlsterm, Society is an umlsterm, standardisation is an umlsterm, terminology is an umlsterm, urinary tract function is an umlsterm, standards is an umlsterm, terminology is an umlsterm, standards is an umlsterm, classification system is an umlsterm, classification is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, clinical investigation is an umlsterm, risks of is an umlsterm, disorder is an umlsterm	DerUrologeA.90380006.eng.abstr_task0	Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]	Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .	[ "Classification", "systems", "of", "bladder", "dysfunction", "are", "mainly", "based", "on", "functional", "and", "urodynamic", "characteristics", ".", "Under", "functional", "aspects", "classification", "relates", "to", "disturbances", "of", "storage", "and", "emptying", "function", "and", "the", "behaviour", "of", "its", "components", ",", "the", "bladder", "and", "the", "bladder", "outlet", ".", "The", "International", "Continence", "Society", "established", "a", "committee", "for", "the", "standardisation", "of", "terminology", "of", "lower", "urinary", "tract", "function", "and", "recommended", "worldwide", "accepted", "standards", "of", "terminology", ".", "These", "standards", "are", "the", "basis", "for", "any", "classification", "system", "and", "should", "be", "used", "to", "facilitate", "comparison", "of", "results", ".", "In", "addition", ",", "classification", "of", "bladder", "dysfunction", "should", "be", "completed", "by", "a", "clinical", "investigation", "to", "define", "the", "risks", "of", "underlaying", "disorder", "." ]	[ "umlsterm" ]
Classification systems is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, urodynamic is an umlsterm, classification is an umlsterm, function is an umlsterm, behaviour is an umlsterm, bladder is an umlsterm, bladder is an umlsterm, Society is an umlsterm, standardisation is an umlsterm, terminology is an umlsterm, urinary tract function is an umlsterm, standards is an umlsterm, terminology is an umlsterm, standards is an umlsterm, classification system is an umlsterm, classification is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, clinical investigation is an umlsterm, risks of is an umlsterm, disorder is an umlsterm	DerUrologeA.90380006.eng.abstr_task1	Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please typing these entity words according to sentence: Classification systems, bladder, dysfunction, urodynamic, classification, function, behaviour, bladder, bladder, Society, standardisation, terminology, urinary tract function, standards, terminology, standards, classification system, classification, bladder, dysfunction, clinical investigation, risks of, disorder Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]	Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .	[ "Classification", "systems", "of", "bladder", "dysfunction", "are", "mainly", "based", "on", "functional", "and", "urodynamic", "characteristics", ".", "Under", "functional", "aspects", "classification", "relates", "to", "disturbances", "of", "storage", "and", "emptying", "function", "and", "the", "behaviour", "of", "its", "components", ",", "the", "bladder", "and", "the", "bladder", "outlet", ".", "The", "International", "Continence", "Society", "established", "a", "committee", "for", "the", "standardisation", "of", "terminology", "of", "lower", "urinary", "tract", "function", "and", "recommended", "worldwide", "accepted", "standards", "of", "terminology", ".", "These", "standards", "are", "the", "basis", "for", "any", "classification", "system", "and", "should", "be", "used", "to", "facilitate", "comparison", "of", "results", ".", "In", "addition", ",", "classification", "of", "bladder", "dysfunction", "should", "be", "completed", "by", "a", "clinical", "investigation", "to", "define", "the", "risks", "of", "underlaying", "disorder", "." ]	[ "umlsterm" ]
Classification systems, bladder, dysfunction, urodynamic, classification, function, behaviour, bladder, bladder, Society, standardisation, terminology, urinary tract function, standards, terminology, standards, classification system, classification, bladder, dysfunction, clinical investigation, risks of, disorder	DerUrologeA.90380006.eng.abstr_task2	Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]	Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .	[ "Classification", "systems", "of", "bladder", "dysfunction", "are", "mainly", "based", "on", "functional", "and", "urodynamic", "characteristics", ".", "Under", "functional", "aspects", "classification", "relates", "to", "disturbances", "of", "storage", "and", "emptying", "function", "and", "the", "behaviour", "of", "its", "components", ",", "the", "bladder", "and", "the", "bladder", "outlet", ".", "The", "International", "Continence", "Society", "established", "a", "committee", "for", "the", "standardisation", "of", "terminology", "of", "lower", "urinary", "tract", "function", "and", "recommended", "worldwide", "accepted", "standards", "of", "terminology", ".", "These", "standards", "are", "the", "basis", "for", "any", "classification", "system", "and", "should", "be", "used", "to", "facilitate", "comparison", "of", "results", ".", "In", "addition", ",", "classification", "of", "bladder", "dysfunction", "should", "be", "completed", "by", "a", "clinical", "investigation", "to", "define", "the", "risks", "of", "underlaying", "disorder", "." ]	[ "umlsterm" ]
anti - coagulation therapy is a Procedure, apart from is a Negation, rivaroxaban is a Drug, Hypersensitivity or allergy is a Scope, factor Xa inhibitors is a Drug, Acute bacterial endocarditis is a Condition, Bleeding disorder is a Condition, active bleeding is a Condition, Gastrointestinal ulcer is a Condition, Hepatic dysfunction is a Condition, increased is a Qualifier, bleeding risk is a Observation, Renal failure is a Condition, dialysis is a Procedure, Gastrectomy is a Procedure, biliopancreatic diversion is a Procedure, resection or re - routing is a Scope, small intestines is a Qualifier, Feeding tube is a Device, blood donation is a Observation, Abnormalities is a Value, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X is a Scope	NCT02970773_exc_task0	Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Observation, Procedure, Negation, Scope, Device, Drug	[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation	[ "Any", "anti", "-", "coagulation", "therapy", "(", "apart", "from", "rivaroxaban", "for", "second", "objective", ")", "\n", "Hypersensitivity", "or", "allergy", "to", "factor", "Xa", "inhibitors", "\n", "Acute", "bacterial", "endocarditis", "\n", "Bleeding", "disorder", "\n", "Clinically", "relevant", "active", "bleeding", "\n", "Gastrointestinal", "ulcer", "or", "tumor", "\n", "Hepatic", "dysfunction", "with", "increased", "bleeding", "risk", "\n", "Renal", "failure", "/", "patients", "undergoing", "dialysis", "\n", "Pregnancy", "and", "breast", "feeding", "\n", "Gastrectomy", ",", "biliopancreatic", "diversion", ",", "resection", "or", "re", "-", "routing", "of", "small", "intestines", "\n", "Feeding", "tube", "\n", "Recent", "blood", "donation", "\n", "Abnormalities", "of", "laboratory", "values", ":", "alanine", "-", "aminotransferase", "(", "ALAT", ")", ",", "aspartate", "-", "aminotransferase", "(", "ASAT", ")", ",", "gamma", "-", "glutamyl", "transferase", "(", "gammaGT", ")", ",", "alkalic", "phosphatase", "(", "AP", ")", ",", "bilirubin", ",", "amylase", ",", "lipase", ",", "cystatin", "C", ",", "creatinine", ",", "white", "blood", "cell", "count", ",", "haemoglobin", ",", "platelet", "count", ",", "prothrombin", "time", ",", "aPTT", ",", "fibrinogen", ",", "thrombin", "time", ",", "factors", "II", ",", "V", ",", "VII", "and", "X", "\n", "Use", "of", "therapeutic", "or", "recreational", "drugs", "influencing", "plasmatic", "coagulation", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]
anti - coagulation therapy is a Procedure, apart from is a Negation, rivaroxaban is a Drug, Hypersensitivity or allergy is a Scope, factor Xa inhibitors is a Drug, Acute bacterial endocarditis is a Condition, Bleeding disorder is a Condition, active bleeding is a Condition, Gastrointestinal ulcer is a Condition, Hepatic dysfunction is a Condition, increased is a Qualifier, bleeding risk is a Observation, Renal failure is a Condition, dialysis is a Procedure, Gastrectomy is a Procedure, biliopancreatic diversion is a Procedure, resection or re - routing is a Scope, small intestines is a Qualifier, Feeding tube is a Device, blood donation is a Observation, Abnormalities is a Value, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X is a Scope	NCT02970773_exc_task1	Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please typing these entity words according to sentence: anti - coagulation therapy, apart from, rivaroxaban, Hypersensitivity or allergy, factor Xa inhibitors, Acute bacterial endocarditis, Bleeding disorder, active bleeding, Gastrointestinal ulcer, Hepatic dysfunction, increased, bleeding risk, Renal failure, dialysis, Gastrectomy, biliopancreatic diversion, resection or re - routing, small intestines, Feeding tube, blood donation, Abnormalities, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X Options: Condition, Qualifier, Value, Observation, Procedure, Negation, Scope, Device, Drug	[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation	[ "Any", "anti", "-", "coagulation", "therapy", "(", "apart", "from", "rivaroxaban", "for", "second", "objective", ")", "\n", "Hypersensitivity", "or", "allergy", "to", "factor", "Xa", "inhibitors", "\n", "Acute", "bacterial", "endocarditis", "\n", "Bleeding", "disorder", "\n", "Clinically", "relevant", "active", "bleeding", "\n", "Gastrointestinal", "ulcer", "or", "tumor", "\n", "Hepatic", "dysfunction", "with", "increased", "bleeding", "risk", "\n", "Renal", "failure", "/", "patients", "undergoing", "dialysis", "\n", "Pregnancy", "and", "breast", "feeding", "\n", "Gastrectomy", ",", "biliopancreatic", "diversion", ",", "resection", "or", "re", "-", "routing", "of", "small", "intestines", "\n", "Feeding", "tube", "\n", "Recent", "blood", "donation", "\n", "Abnormalities", "of", "laboratory", "values", ":", "alanine", "-", "aminotransferase", "(", "ALAT", ")", ",", "aspartate", "-", "aminotransferase", "(", "ASAT", ")", ",", "gamma", "-", "glutamyl", "transferase", "(", "gammaGT", ")", ",", "alkalic", "phosphatase", "(", "AP", ")", ",", "bilirubin", ",", "amylase", ",", "lipase", ",", "cystatin", "C", ",", "creatinine", ",", "white", "blood", "cell", "count", ",", "haemoglobin", ",", "platelet", "count", ",", "prothrombin", "time", ",", "aPTT", ",", "fibrinogen", ",", "thrombin", "time", ",", "factors", "II", ",", "V", ",", "VII", "and", "X", "\n", "Use", "of", "therapeutic", "or", "recreational", "drugs", "influencing", "plasmatic", "coagulation", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]
anti - coagulation therapy, apart from, rivaroxaban, Hypersensitivity or allergy, factor Xa inhibitors, Acute bacterial endocarditis, Bleeding disorder, active bleeding, Gastrointestinal ulcer, Hepatic dysfunction, increased, bleeding risk, Renal failure, dialysis, Gastrectomy, biliopancreatic diversion, resection or re - routing, small intestines, Feeding tube, blood donation, Abnormalities, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X	NCT02970773_exc_task2	Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please extract entity words from the input sentence	[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation	[ "Any", "anti", "-", "coagulation", "therapy", "(", "apart", "from", "rivaroxaban", "for", "second", "objective", ")", "\n", "Hypersensitivity", "or", "allergy", "to", "factor", "Xa", "inhibitors", "\n", "Acute", "bacterial", "endocarditis", "\n", "Bleeding", "disorder", "\n", "Clinically", "relevant", "active", "bleeding", "\n", "Gastrointestinal", "ulcer", "or", "tumor", "\n", "Hepatic", "dysfunction", "with", "increased", "bleeding", "risk", "\n", "Renal", "failure", "/", "patients", "undergoing", "dialysis", "\n", "Pregnancy", "and", "breast", "feeding", "\n", "Gastrectomy", ",", "biliopancreatic", "diversion", ",", "resection", "or", "re", "-", "routing", "of", "small", "intestines", "\n", "Feeding", "tube", "\n", "Recent", "blood", "donation", "\n", "Abnormalities", "of", "laboratory", "values", ":", "alanine", "-", "aminotransferase", "(", "ALAT", ")", ",", "aspartate", "-", "aminotransferase", "(", "ASAT", ")", ",", "gamma", "-", "glutamyl", "transferase", "(", "gammaGT", ")", ",", "alkalic", "phosphatase", "(", "AP", ")", ",", "bilirubin", ",", "amylase", ",", "lipase", ",", "cystatin", "C", ",", "creatinine", ",", "white", "blood", "cell", "count", ",", "haemoglobin", ",", "platelet", "count", ",", "prothrombin", "time", ",", "aPTT", ",", "fibrinogen", ",", "thrombin", "time", ",", "factors", "II", ",", "V", ",", "VII", "and", "X", "\n", "Use", "of", "therapeutic", "or", "recreational", "drugs", "influencing", "plasmatic", "coagulation", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]
chemokine receptor CCR5 is a GENE-N	16298345_task0	Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]	Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.	[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
chemokine receptor CCR5 is a GENE-N	16298345_task1	Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please typing these entity words according to sentence: chemokine receptor CCR5 Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]	Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.	[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
chemokine receptor CCR5	16298345_task2	Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]	Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.	[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Na+/K+/2Cl- cotransporter is a GENE-N	10831596_task0	Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]	Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.	[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Na+/K+/2Cl- cotransporter is a GENE-N	10831596_task1	Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please typing these entity words according to sentence: Na+/K+/2Cl- cotransporter Options: GENE-N	[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]	Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.	[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Na+/K+/2Cl- cotransporter	10831596_task2	Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]	Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.	[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
kidney is a Organ, kidney is a Organ, T - cell is a Cell, kidney is a Organ	PMC-2690976-sec-05_task0	Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Organ, Cell	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.	[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]	[ "Organ", "Cell" ]
kidney is a Organ, kidney is a Organ, T - cell is a Cell, kidney is a Organ	PMC-2690976-sec-05_task1	Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please typing these entity words according to sentence: kidney, kidney, T - cell, kidney Options: Organ, Cell	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.	[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]	[ "Organ", "Cell" ]
kidney, kidney, T - cell, kidney	PMC-2690976-sec-05_task2	Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.	[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]	[ "Organ", "Cell" ]
man is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, cystectomy is an umlsterm, lymphadenectomy is an umlsterm, lymph nodes is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, lymph nodes is an umlsterm, symptoms is an umlsterm, plan is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, tumors is an umlsterm	DerUrologeA.00390572.eng.abstr_task0	Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .	[ "We", "report", "on", "a", "44-year", "-", "old", "man", "with", "the", "rare", "case", "of", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", ".", "We", "performed", "extended", "partial", "cystectomy", "with", "regional", "staging", "lymphadenectomy", "of", "the", "obturator", "lymph", "nodes", ".", "Histological", "investigation", "revealed", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", "with", "negative", "lymph", "nodes", ".", "For", "this", "case", ",", "we", "present", "symptoms", ",", "a", "plan", "for", "diagnosis", ",", "and", "treatment", "of", "these", "tumors", "." ]	[ "umlsterm" ]
man is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, cystectomy is an umlsterm, lymphadenectomy is an umlsterm, lymph nodes is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, lymph nodes is an umlsterm, symptoms is an umlsterm, plan is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, tumors is an umlsterm	DerUrologeA.00390572.eng.abstr_task1	Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please typing these entity words according to sentence: man, mucin - positive, carcinoma, urachus, cystectomy, lymphadenectomy, lymph nodes, mucin - positive, carcinoma, urachus, lymph nodes, symptoms, plan, diagnosis, treatment, tumors Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .	[ "We", "report", "on", "a", "44-year", "-", "old", "man", "with", "the", "rare", "case", "of", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", ".", "We", "performed", "extended", "partial", "cystectomy", "with", "regional", "staging", "lymphadenectomy", "of", "the", "obturator", "lymph", "nodes", ".", "Histological", "investigation", "revealed", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", "with", "negative", "lymph", "nodes", ".", "For", "this", "case", ",", "we", "present", "symptoms", ",", "a", "plan", "for", "diagnosis", ",", "and", "treatment", "of", "these", "tumors", "." ]	[ "umlsterm" ]
man, mucin - positive, carcinoma, urachus, cystectomy, lymphadenectomy, lymph nodes, mucin - positive, carcinoma, urachus, lymph nodes, symptoms, plan, diagnosis, treatment, tumors	DerUrologeA.00390572.eng.abstr_task2	Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .	[ "We", "report", "on", "a", "44-year", "-", "old", "man", "with", "the", "rare", "case", "of", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", ".", "We", "performed", "extended", "partial", "cystectomy", "with", "regional", "staging", "lymphadenectomy", "of", "the", "obturator", "lymph", "nodes", ".", "Histological", "investigation", "revealed", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", "with", "negative", "lymph", "nodes", ".", "For", "this", "case", ",", "we", "present", "symptoms", ",", "a", "plan", "for", "diagnosis", ",", "and", "treatment", "of", "these", "tumors", "." ]	[ "umlsterm" ]
IL-10 is a Protein, IL-12 is a Protein, STAT4 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, OVA is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IFN - gamma is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein	97_task0	Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.	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IL-10 is a Protein, IL-12 is a Protein, STAT4 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, OVA is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IFN - gamma is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein	97_task1	Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please typing these entity words according to sentence: IL-10, IL-12, STAT4, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, IL-12, IL-10, IL-10, IL-12, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, OVA, IL-12, IL-12, IL-10, CD4, IL-12, IFN - gamma, IL-10, IL-10, IL-12, IL-12, IL-10 Options: Protein	[ "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.	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IL-10, IL-12, STAT4, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, IL-12, IL-10, IL-10, IL-12, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, OVA, IL-12, IL-12, IL-10, CD4, IL-12, IFN - gamma, IL-10, IL-10, IL-12, IL-12, IL-10	97_task2	Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please extract entity words from the input sentence	[ "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.	[ "IL-10", "Production", "Is", "Maintained", "by", "High", "TCR", "Signal", "Strength", "and", "IL-12", "\n", "We", "next", "investigated", "whether", "repeated", "strong", "TCR", "activation", "is", "a", "compensatory", "signal", "for", "IL-12-induced", "STAT4", "signaling", "in", "the", "induction", "of", "IL-10", "in", "Th1", "cells", ".", "For", "this", ",", "CD4", "+", "Tcells", "were", "differentiated", "for", "2", "consecutive", "weeks", "with", "high", "antigen", "doses", "in", "the", "presence", "or", "absence", "of", "IL-12", "throughout", "(", "Figures", "4A-4D", ")", ".", "High", "antigen", "dose", "and", "IL-12", "cooperated", "to", "induce", "maximal", "IL-10", "production", "(", "Figures", "4A", "and", "4B", ")", ",", "given", "that", "this", "combination", "resulted", "in", "the", "highest", "numbers", "of", "IL-10-producing", "Th1", "cells", ".", "Repeated", "high", "antigen", "dose", "stimulation", "in", "the", "absence", "of", "exogenously", "added", "IL-12", "resulted", "in", "the", "production", "of", "IL-10", "by", "Th1", "cells", ",", "suggesting", "that", "repeated", "strong", "TCR", "triggering", "may", "overcome", "the", "need", "for", "IL-12", "for", "IL-10", "induction", "(", "Figures", "4C", "and", "4D", ")", ".", "However", ",", "IL-10", "induction", "under", "these", "conditions", "was", "abrogated", "when", "IL-12p40-deficient", "DCs", "were", "used", "as", "APCs", "(", "Figure4E", ")", ".", "Thus", ",", "IL-12", "is", "essential", "during", "both", "primary", "and", "secondary", "antigenic", "stimulation", "for", "production", "of", "IL-10", "by", "Th1", "cells", ".", "\n", "To", "determine", "the", "requirements", "for", "stability", "of", "the", "IL-10-producing", "Th1", "cells", ",", "we", "differentiated", "CD4", "+", "Tcells", "for", "1", "week", "with", "high", "antigen", "doses", "with", "or", "without", "IL-12", "(", "Figures", "4A", "and", "4C", ")", ",", "washed", "them", ",", "and", "then", "restimulated", "them", "for", "an", "additional", "week", "with", "a", "low", "antigen", "dose", ",", "in", "the", "absence", "or", "presence", "of", "IL-12", "(", "Figure4F", ")", ".", "Th1", "cells", "induced", "in", "the", "first", "week", "to", "produce", "IL-10", "by", "culture", "with", "high", "antigen", "doses", "and", "IL-12", "lost", "their", "ability", "to", "express", "IL-10", "when", "recultured", "with", "low", "doses", "of", "OVA", ",", "which", "could", "be", "compensated", "for", ",", "to", "some", "extent", ",", "by", "addition", "of", "IL-12", "to", "the", "secondary", "cultures", "(", "Figure4F", ")", ",", "again", "suggesting", "that", "antigen", "dose", "and", "IL-12", "signals", "cooperate", "for", "the", "induction", "of", "IL-10", ".", "Finally", ",", "DO11.10", "CD4", "+", "cells", "that", "were", "exposed", "to", "low", "doses", "of", "antigen", "and", "IL-12", "during", "the", "primary", "differentiation", "phase", "produced", "high", "amounts", "of", "IFN", "-", "gamma", "but", "little", "IL-10", ",", "but", "they", "could", "be", "induced", "to", "produce", "IL-10", "when", "both", "high", "antigen", "dose", "and", "IL-12", "were", "present", "during", "the", "recall", "phase", "(", "FigureS4", ")", ".", "Thus", ",", "high", "antigen", "dose", "and", "IL-12", "are", "required", "for", "sustaining", "the", "induction", "of", "IL-10", "production", "by", "Th1", "cells", ".", "\n" ]	[ "Protein" ]
Trichostatin A is a CHEMICAL, transforming growth factor - β is a GENE-Y, oxygen is a CHEMICAL	23284002_task0	Sentence: Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.	[ "Trichostatin", "A", "inhibits", "transforming", "growth", "factor", "-", "β", "-", "induced", "reactive", "oxygen", "species", "accumulation", "and", "myofibroblast", "differentiation", "via", "enhanced", "NF", "-", "E2-related", "factor", "2-antioxidant", "response", "element", "signaling", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Trichostatin A is a CHEMICAL, transforming growth factor - β is a GENE-Y, oxygen is a CHEMICAL	23284002_task1	Sentence: Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. Instructions: please typing these entity words according to sentence: Trichostatin A, transforming growth factor - β, oxygen Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.	[ "Trichostatin", "A", "inhibits", "transforming", "growth", "factor", "-", "β", "-", "induced", "reactive", "oxygen", "species", "accumulation", "and", "myofibroblast", "differentiation", "via", "enhanced", "NF", "-", "E2-related", "factor", "2-antioxidant", "response", "element", "signaling", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]

laminin is a Individual_protein, myosin heavy chain is a Individual_protein, MHC is a Individual_protein, alpha - skeletal actin is a Individual_protein

702_task1

Sentence: The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture. Instructions: please typing these entity words according to sentence: laminin, myosin heavy chain, MHC, alpha - skeletal actin Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture.

[ "The", "effects", "of", "two", "adhesion", "substrates", "(", "serum", "and", "laminin", ")", "and", "time", "in", "culture", "on", "the", "expression", "of", "genes", "encoding", "myosin", "heavy", "chain", "(", "MHC", ")", "isoforms", "and", "alpha", "-", "skeletal", "actin", "were", "analysed", "in", "myocytes", "isolated", "from", "adult", "rat", "heart", "and", "maintained", "in", "serum", "-", "free", "culture", "." ]

[ "Individual_protein" ]

laminin, myosin heavy chain, MHC, alpha - skeletal actin

702_task2

Sentence: The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of two adhesion substrates (serum and laminin) and time in culture on the expression of genes encoding myosin heavy chain (MHC) isoforms and alpha-skeletal actin were analysed in myocytes isolated from adult rat heart and maintained in serum-free culture.

[ "The", "effects", "of", "two", "adhesion", "substrates", "(", "serum", "and", "laminin", ")", "and", "time", "in", "culture", "on", "the", "expression", "of", "genes", "encoding", "myosin", "heavy", "chain", "(", "MHC", ")", "isoforms", "and", "alpha", "-", "skeletal", "actin", "were", "analysed", "in", "myocytes", "isolated", "from", "adult", "rat", "heart", "and", "maintained", "in", "serum", "-", "free", "culture", "." ]

[ "Individual_protein" ]

skull is an umlsterm, titanium is an umlsterm, bone replacement material is an umlsterm, tissue is an umlsterm, surgical is an umlsterm, technique is an umlsterm, patient is an umlsterm, transfer is an umlsterm, evaluation is an umlsterm, postoperative is an umlsterm, use is an umlsterm, techniques is an umlsterm, implants is an umlsterm, laws is an umlsterm, documentation is an umlsterm, computer - based is an umlsterm, skull is an umlsterm, procedure is an umlsterm, titanium is an umlsterm, technique is an umlsterm, elements is an umlsterm, defects is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, patients is an umlsterm, hospital is an umlsterm, postoperative is an umlsterm, MRI is an umlsterm, documentation is an umlsterm, control is an umlsterm, documentation is an umlsterm, techniques is an umlsterm, bone is an umlsterm, Hand is an umlsterm, hand is an umlsterm, research is an umlsterm, criteria is an umlsterm, techniques is an umlsterm, determination is an umlsterm, MRI is an umlsterm, magnetic is an umlsterm, titanium is an umlsterm, postoperative is an umlsterm, documentation is an umlsterm, tumor is an umlsterm, surgery is an umlsterm

MundKieferGesichtschirurgie.0004s504.eng.abstr_task0

Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .

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[ "umlsterm" ]

skull is an umlsterm, titanium is an umlsterm, bone replacement material is an umlsterm, tissue is an umlsterm, surgical is an umlsterm, technique is an umlsterm, patient is an umlsterm, transfer is an umlsterm, evaluation is an umlsterm, postoperative is an umlsterm, use is an umlsterm, techniques is an umlsterm, implants is an umlsterm, laws is an umlsterm, documentation is an umlsterm, computer - based is an umlsterm, skull is an umlsterm, procedure is an umlsterm, titanium is an umlsterm, technique is an umlsterm, elements is an umlsterm, defects is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, patients is an umlsterm, hospital is an umlsterm, postoperative is an umlsterm, MRI is an umlsterm, documentation is an umlsterm, control is an umlsterm, documentation is an umlsterm, techniques is an umlsterm, bone is an umlsterm, Hand is an umlsterm, hand is an umlsterm, research is an umlsterm, criteria is an umlsterm, techniques is an umlsterm, determination is an umlsterm, MRI is an umlsterm, magnetic is an umlsterm, titanium is an umlsterm, postoperative is an umlsterm, documentation is an umlsterm, tumor is an umlsterm, surgery is an umlsterm

MundKieferGesichtschirurgie.0004s504.eng.abstr_task1

Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please typing these entity words according to sentence: skull, titanium, bone replacement material, tissue, surgical, technique, patient, transfer, evaluation, postoperative, use, techniques, implants, laws, documentation, computer - based, skull, procedure, titanium, technique, elements, defects, tumor, surgery, patients, hospital, postoperative, MRI, documentation, control, documentation, techniques, bone, Hand, hand, research, criteria, techniques, determination, MRI, magnetic, titanium, postoperative, documentation, tumor, surgery Options: umlsterm

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Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .

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[ "umlsterm" ]

skull, titanium, bone replacement material, tissue, surgical, technique, patient, transfer, evaluation, postoperative, use, techniques, implants, laws, documentation, computer - based, skull, procedure, titanium, technique, elements, defects, tumor, surgery, patients, hospital, postoperative, MRI, documentation, control, documentation, techniques, bone, Hand, hand, research, criteria, techniques, determination, MRI, magnetic, titanium, postoperative, documentation, tumor, surgery

MundKieferGesichtschirurgie.0004s504.eng.abstr_task2

Sentence: Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery . Instructions: please extract entity words from the input sentence

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Computer-assisted prefabricated skull implants of pure titanium as a bone replacement material have been used in 22 departments since 1994. Our experience with 104 implants includes clinical aspects ( indication ; tissue quality ; surgical technique ; patient guidance ) , but also geometric and material-specific parameters ( acquisition , transfer , and evaluation of CT data ; construction ; manufacturing ; cleaning ; postoperative use of radiologic techniques ) . While the clinical aspects are responsibly defined by the respective surgeon , the geometric and material-specific parameters of individual implants have to comply with the laws on medical products . Therefore , the prospective documentation for each implant includes : helical CT acquisition parameters ; geometric data of the computer-based skull model and implant ; the cleaning procedure ; and the individual marking . Medically specified pure titanium is processed by milling only so that neither purity nor structure is impaired . A specially developed milling technique guarantees the fabrication of all constructed elements down to fine details of 50 µm. Considering the necessary radiologic follow-up of defects after tumor surgery , all patients in our hospital undergo postoperative MRI examination , partly with preoperative documentation as an intraindividual control . Such comprehensive documentation and quality assurance is essential for techniques of prefabricated bone substitution . Hand in hand with scientific research and clinical application , these formal criteria have to be elaborated and fulfilled for the respective techniques . The successful determination of specifically adapted MRI sequences goes even one step further : spin-echo sequences minimize inhomogeneities of the magnetic field induced by the titanium implants and enable accurate postoperative documentation and diagnostics especially in the follow-up after tumor surgery .

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[ "umlsterm" ]

myosin heavy chain is a Individual_protein, MHC is a Individual_protein, actin is a Gene/protein/RNA

758_task0

Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.

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[ "Individual_protein", "Gene/protein/RNA" ]

myosin heavy chain is a Individual_protein, MHC is a Individual_protein, actin is a Gene/protein/RNA

758_task1

Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please typing these entity words according to sentence: myosin heavy chain, MHC, actin Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.

[ "The", "primary", "purpose", "of", "this", "study", "was", "to", "determine", "the", "relationship", "between", "myosin", "heavy", "chain", "(", "MHC", ")", "and", "actin", "contents", "and", "maximum", "isometric", "tetanic", "force", "(", "Po", ")", "in", "mouse", "extensor", "digitorum", "longus", "(", "EDL", ")", "muscles", "following", "eccentric", "contraction", "-", "induced", "injury", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

myosin heavy chain, MHC, actin

758_task2

Sentence: The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The primary purpose of this study was to determine the relationship between myosin heavy chain (MHC) and actin contents and maximum isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles following eccentric contraction-induced injury.

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[ "Individual_protein", "Gene/protein/RNA" ]

both sexes is a Person, from 18 years is a Value, community - acquired pneumonia is a Condition, COPD is a Condition, Bronchial Asthma is a Condition, community - acquired pneumonia is a Condition, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 % is a Scope, COPD is a Condition, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction is a Scope

NCT02787863_inc_task0

Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Person, Condition, Value

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Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.

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[ "Scope", "Condition", "Qualifier", "Temporal", "Procedure", "Observation", "Value", "Person", "Multiplier", "Measurement" ]

both sexes is a Person, from 18 years is a Value, community - acquired pneumonia is a Condition, COPD is a Condition, Bronchial Asthma is a Condition, community - acquired pneumonia is a Condition, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 % is a Scope, COPD is a Condition, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction is a Scope

NCT02787863_inc_task1

Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please typing these entity words according to sentence: both sexes, from 18 years, community - acquired pneumonia, COPD, Bronchial Asthma, community - acquired pneumonia, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 %, COPD, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction Options: Scope, Person, Condition, Value

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Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.

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[ "Scope", "Condition", "Qualifier", "Temporal", "Procedure", "Observation", "Value", "Person", "Multiplier", "Measurement" ]

both sexes, from 18 years, community - acquired pneumonia, COPD, Bronchial Asthma, community - acquired pneumonia, radiologically confirmed infiltration of the lung tissue ; the presence of at least two of the following clinical signs : acute fever early in the disease ( temperature > 38.0 ° C ) , cough with sputum , the physical signs of pneumonia ( focus of crepitate and / or fine bubble rales , bronchial breathing hard , shortening of percussion sounds ) , leukocytosis > 10 * 10 9 /l and / or stab shift > 10 %, COPD, dyspnea : progressive ( worsens over time ) , increases with exertion , persistent ; chronic cough ( may appear sporadically and may be unproductive ) ; chronic expectoration ; the impact of risk factors in the medical history ( Smoking , occupational dust pollutants and chemicals ) ; widespread wheeze on auscultation of the chest and / or distant wheezing in the chest ; family history of COPD ; spirometric data confirming the presence of fixed bronchial obstruction

NCT02787863_inc_task2

Sentence: Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction. Instructions: please extract entity words from the input sentence

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Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma; The presence of signed and dated informed consent to participate in a clinical study; The ability to perform the requirements of the Protocol; For women of childbearing age is a negative result of a pregnancy test before vaccination. community-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.). COPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.

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gadolinio is a NORMALIZABLES

450_task0

Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES

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Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.

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[ "NORMALIZABLES" ]

gadolinio is a NORMALIZABLES

450_task1

Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. Instructions: please typing these entity words according to sentence: gadolinio Options: NORMALIZABLES

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Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.

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[ "NORMALIZABLES" ]

gadolinio

450_task2

Sentence: Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR. Instructions: please extract entity words from the input sentence

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Niño de cinco años derivado por su pediatra de Atención Primaria para estudio por deformidad craneal frontoparietotemporal derecha que se había hecho más evidente en los últimos meses. Había presentado vómitos ocasionales con los malos olores, de un año de evolución, y cefalea acompañada de sonofobia y fonofobia, de frecuencia variable e intensidad leve que nunca le había despertado por la noche desde los tres años y medio. La exploración neurológica fue normal (incluido el fondo de ojo), excepto la macrocefalia con 55 cm de perímetro cefálico (>percentil 99). El único antecedente familiar significativo es un QA frontal izquierdo intervenido en el abuelo paterno. Nacido de embarazo controlado, con ecografías prenatales normales y parto eutócico sin complicaciones. No tenía otros antecedentes personales de interés. El desarrollo psicomotor fue normal, con marcha libre a los 13 meses, lenguaje y sociabilidad adecuada a la edad, y está escolarizado con dificultades de aprendizaje de la lectoescritura. En la TC cranealse visualiza un QA de gran tamaño en la fosa craneal media derecha con desplazamiento de la línea media y colapso de las astas ventriculares adyacentes, que se confirma en RM craneal mostrando en la región frontoparietotemporal derecha un contenido hipointenso en secuencias de T1 e hiperintensas en T2; que no se modifica tras el contraste con gadolinio. Se deriva a Neurocirugía, donde se monitorizan las presiones intracraneales con un sensor epidural neumático, mediante trépano frontal precoronal, encontrando patológicas solo las nocturnas. Ante una hipertensión intracraneal crónica, se decide tratamiento con cistocisternostomía, comunicando el QA con la cisterna óptico-carotídea, mediante endoscopio angulado 30° y un catéter con doble balón de ventriculostomía, para favorecer la comunicación de los espacios y la circulación libre del LCR.

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[ "NORMALIZABLES" ]

prostanoids is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, pulmonary circulation is an umlsterm, use is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, lung transplantation is an umlsterm, patients is an umlsterm, adult is an umlsterm, respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, vascular resistance is an umlsterm, pressure is an umlsterm, gas is an umlsterm, PGI2 is an umlsterm, aerosol is an umlsterm, vasodilator is an umlsterm, nitric oxide is an umlsterm, aerosol is an umlsterm, PGI2 is an umlsterm, iloprost is an umlsterm, long - term treatment is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, pulmonary hypertension is an umlsterm

IntensiveMedizin.70340370.eng.abstr_task0

Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .

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[ "umlsterm" ]

prostanoids is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, pulmonary circulation is an umlsterm, use is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, lung transplantation is an umlsterm, patients is an umlsterm, adult is an umlsterm, respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, PGE1 is an umlsterm, PGI2 is an umlsterm, vascular resistance is an umlsterm, pressure is an umlsterm, gas is an umlsterm, PGI2 is an umlsterm, aerosol is an umlsterm, vasodilator is an umlsterm, nitric oxide is an umlsterm, aerosol is an umlsterm, PGI2 is an umlsterm, iloprost is an umlsterm, long - term treatment is an umlsterm, patients is an umlsterm, pulmonary hypertension is an umlsterm, pulmonary hypertension is an umlsterm

IntensiveMedizin.70340370.eng.abstr_task1

Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please typing these entity words according to sentence: prostanoids, PGE1, PGI2, pulmonary circulation, use, patients, pulmonary hypertension, lung transplantation, patients, adult, respiratory distress syndrome, ARDS, PGE1, PGI2, vascular resistance, pressure, gas, PGI2, aerosol, vasodilator, nitric oxide, aerosol, PGI2, iloprost, long - term treatment, patients, pulmonary hypertension, pulmonary hypertension Options: umlsterm

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The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .

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[ "umlsterm" ]

prostanoids, PGE1, PGI2, pulmonary circulation, use, patients, pulmonary hypertension, lung transplantation, patients, adult, respiratory distress syndrome, ARDS, PGE1, PGI2, vascular resistance, pressure, gas, PGI2, aerosol, vasodilator, nitric oxide, aerosol, PGI2, iloprost, long - term treatment, patients, pulmonary hypertension, pulmonary hypertension

IntensiveMedizin.70340370.eng.abstr_task2

Sentence: The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension . Instructions: please extract entity words from the input sentence

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The vasodilatory prostanoids PGE1 and PGI2 possess strong vasodilatory potency in the pulmonary circulation . Their application is , however , limited by the lack of pulmonary and intrapulmonary selectivity . By use of chronic ambulatory PGI2-infusion, patients with primary pulmonary hypertension ( PPH ) may be bridged for ( heart- ) lung transplantation . In patients with adult respiratory distress syndrome ( ARDS ) , PGE1 and PGI2 lower the pulmonary vascular resistance , but may also decrease the systemic pressure ( limited pulmonary selectivity ) and increase ventilation-perfusion-mismatch , accompanied by an impairment of gas exchange ( limited intrapulmonary selectivity ) . Application of PGI2 via the transbronchial route ( aerosol ) may achieve pulmonary and intrapulmonary selectivity with an efficacy profile comparable to that of the selective pulmonary vasodilator nitric oxide ( NO ) . Repetitive aerosol application of the stable PGI2 analogue iloprost is under consideration for long-term treatment of patients with severe pulmonary hypertension such as primary pulmonary hypertension .

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[ "umlsterm" ]

Berlin is an umlsterm, Unfallerfahrungen is an umlsterm, Aerzte is an umlsterm, Aerzten is an umlsterm, Aerzte is an umlsterm, Unfaellen is an umlsterm, Aerzte is an umlsterm, Unfallerfahrung is an umlsterm, Aerzte is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Rolle is an umlsterm, Patienten is an umlsterm, Befundarmut is an umlsterm, Arzt is an umlsterm

Rechtsmedizin.80080178.ger.abstr_task0

Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .

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[ "umlsterm" ]

Berlin is an umlsterm, Unfallerfahrungen is an umlsterm, Aerzte is an umlsterm, Aerzten is an umlsterm, Aerzte is an umlsterm, Unfaellen is an umlsterm, Aerzte is an umlsterm, Unfallerfahrung is an umlsterm, Aerzte is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Rolle is an umlsterm, Patienten is an umlsterm, Befundarmut is an umlsterm, Arzt is an umlsterm

Rechtsmedizin.80080178.ger.abstr_task1

Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please typing these entity words according to sentence: Berlin, Unfallerfahrungen, Aerzte, Aerzten, Aerzte, Unfaellen, Aerzte, Unfallerfahrung, Aerzte, Unfall, Patienten, Behandlung, Rolle, Patienten, Befundarmut, Arzt Options: umlsterm

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Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .

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[ "umlsterm" ]

Berlin, Unfallerfahrungen, Aerzte, Aerzten, Aerzte, Unfaellen, Aerzte, Unfallerfahrung, Aerzte, Unfall, Patienten, Behandlung, Rolle, Patienten, Befundarmut, Arzt

Rechtsmedizin.80080178.ger.abstr_task2

Sentence: Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten . Instructions: please extract entity words from the input sentence

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Im Maerz 1997 wurden alle 459 in Berlin praktizierenden Chirurgen und Orthopaeden schriftlich nach ihren Erfahrungen mit atraumatischen und posttraumatischen HWS-Beschwerden befragt . Der Ruecklauf betrug rund 25% . Bemerkenswerterweise beeinflussten persoenliche Unfallerfahrungen ( als Fahrzeuginsasse ) die Sichtweise der Aerzte : von den 26 Aerzten mit eigenen posttraumatischen HWS-Beschwerden hielten 54% eine solche Symptomatik fuer traumaspezifisch , waehrend dies nur 35% der 40 Aerzte mit Unfaellen , aber ohne HWS-Beschwerden so sahen . 22% der Aerzte ohne Unfallerfahrung gegenueber 62% der Aerzte mit bezogen auf die HWS folgenlosem Unfall gaben an , materielle Begehrlichkeiten von Patienten wuerden haeufig in Symptomatik und Behandlung eine Rolle spielen . Angesichts seiner speziellen Beziehung zum Patienten sowie aufgrund der typischen Befundarmut des Beschwerdebildes hat es der behandelnde Arzt allerdings schwer , von ihm u. U. als ueberzogen empfundenen Begehrlichkeiten entgegenzutreten .

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[ "umlsterm" ]

Technik is an umlsterm, Zona pellucida is an umlsterm, heranwachsenden is an umlsterm, Embryos is an umlsterm, Embryo is an umlsterm, Zona pellucida is an umlsterm, Schwangerschaft is an umlsterm, Technik is an umlsterm

DerGynaekologe.00330772.ger.abstr_task0

Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .

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[ "umlsterm" ]

Technik is an umlsterm, Zona pellucida is an umlsterm, heranwachsenden is an umlsterm, Embryos is an umlsterm, Embryo is an umlsterm, Zona pellucida is an umlsterm, Schwangerschaft is an umlsterm, Technik is an umlsterm

DerGynaekologe.00330772.ger.abstr_task1

Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please typing these entity words according to sentence: Technik, Zona pellucida, heranwachsenden, Embryos, Embryo, Zona pellucida, Schwangerschaft, Technik Options: umlsterm

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Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .

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[ "umlsterm" ]

Technik, Zona pellucida, heranwachsenden, Embryos, Embryo, Zona pellucida, Schwangerschaft, Technik

DerGynaekologe.00330772.ger.abstr_task2

Sentence: Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Die Technik des assisted hatching " " wurde erstmals 1990 beschrieben . Durch die Erzeugung einer kuenstlichen Oeffnung in der Zona pellucida des heranwachsenden Embryos sollte gewaehrleistet werden , dass der Embryo im Blastozystenstadium zuverlaessig aus der Zona pellucida ausschluepft . Dies ist eine wesentliche Vorbedingung fuer eine erfolgreiche Implantation und den Eintritt einer Schwangerschaft . Seit Einfuehrung des assisted hatching " " werden die Bedeutung und Einsatzmoeglichkeiten dieser Technik kontrovers diskutiert .

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[ "umlsterm" ]

respiratory failure is an umlsterm, CRF is an umlsterm, respiratory muscles is an umlsterm, neuromuscular diseases is an umlsterm, kypho - scoliosis is an umlsterm, obstructive lung disease is an umlsterm, CRF is an umlsterm, hypercapnia is an umlsterm, hypoxemia is an umlsterm, hypercapnia is an umlsterm, respiratory muscles is an umlsterm, indicator is an umlsterm

IntensiveMedizin.70340501.eng.abstr_task0

Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .

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[ "umlsterm" ]

respiratory failure is an umlsterm, CRF is an umlsterm, respiratory muscles is an umlsterm, neuromuscular diseases is an umlsterm, kypho - scoliosis is an umlsterm, obstructive lung disease is an umlsterm, CRF is an umlsterm, hypercapnia is an umlsterm, hypoxemia is an umlsterm, hypercapnia is an umlsterm, respiratory muscles is an umlsterm, indicator is an umlsterm

IntensiveMedizin.70340501.eng.abstr_task1

Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please typing these entity words according to sentence: respiratory failure, CRF, respiratory muscles, neuromuscular diseases, kypho - scoliosis, obstructive lung disease, CRF, hypercapnia, hypoxemia, hypercapnia, respiratory muscles, indicator Options: umlsterm

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Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .

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[ "umlsterm" ]

respiratory failure, CRF, respiratory muscles, neuromuscular diseases, kypho - scoliosis, obstructive lung disease, CRF, hypercapnia, hypoxemia, hypercapnia, respiratory muscles, indicator

IntensiveMedizin.70340501.eng.abstr_task2

Sentence: Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator . Instructions: please extract entity words from the input sentence

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Chronic respiratory failure ( CRF ) is caused by a decrease in the capacity of the respiratory muscles ( e . g . , neuromuscular diseases ) , or an increase in load ( e . g . , kypho-scoliosis or obstructive lung disease ) or both . CRF is characterized by hypercapnia and hypoxemia . The degree of hypercapnia is directly related to the increase of the load and decrease of the capacity of the respiratory muscles and acts , therefore , as an indicator .

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[ "umlsterm" ]

Adipose tissue is a Tissue, endocrine tissue is a Tissue, synovial fluid is a Organism_substance, sera is a Organism_substance, synovial fibroblasts is a Cell, synovial cell is a Cell, cardiovascular is a Multi-tissue_structure, joint fluid is a Organism_substance

PMC-3003518-sec-05_task0

Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Cell, Multi-tissue_structure, Organism_substance

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Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).

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[ "Cell", "Tissue", "Organism_substance", "Multi-tissue_structure" ]

Adipose tissue is a Tissue, endocrine tissue is a Tissue, synovial fluid is a Organism_substance, sera is a Organism_substance, synovial fibroblasts is a Cell, synovial cell is a Cell, cardiovascular is a Multi-tissue_structure, joint fluid is a Organism_substance

PMC-3003518-sec-05_task1

Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please typing these entity words according to sentence: Adipose tissue, endocrine tissue, synovial fluid, sera, synovial fibroblasts, synovial cell, cardiovascular, joint fluid Options: Tissue, Cell, Multi-tissue_structure, Organism_substance

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Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).

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[ "Cell", "Tissue", "Organism_substance", "Multi-tissue_structure" ]

Adipose tissue, endocrine tissue, synovial fluid, sera, synovial fibroblasts, synovial cell, cardiovascular, joint fluid

PMC-3003518-sec-05_task2

Sentence: Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA). Instructions: please extract entity words from the input sentence

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Introduction Adipose tissue, once viewed as simply a storage and release depot for lipids, is now considered an endocrine tissue [1,2] that secretes various substances (adipokines), including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, leptin, adiponectin, resistin, visfatin, and omenetin [3,4]. Among these adipokines, much attention has been paid to adiponectin's relationship with insulin sensitivity and glucose and lipid metabolism in the past 10 years. In addition, adiponectin is known to exhibit potent anti-inflammatory [5], atheroprotective [6], and antidiabetic [7] effects. Recent findings suggest that adiponectin may be involved in the pathogenesis of rheumatoid arthritis (RA). Levels of adiponectin in synovial fluid and sera were elevated in patients with RA [8,9]. Adiponectin also induces the production of proinflammatory cytokines, IL-6, matrix metalloproteinase (MMP)-1, and IL-8 from RA synovial fibroblasts in vitro [10,11]. Thus, it was suggested that adiponectin can also exert significant proinflammatory and matrix-degrading effects. However, the role of adiponectin in the pathogenesis of RA is still controversial because of conflicting reports about its function [10,12-15]. In particular, adiponectin seems to play an anti-inflammatory role because it significantly inhibited IL-1beta-stimulated synovial cell proliferation in collagen-induced arthritic mice, despite increased IL-6 expression [16]. In contrast, high-grade inflammation in RA patients was negatively correlated with circulating adiponectin concentrations [17]. Rather, it was suggested that circulating adiponectin may be involved in cardiovascular disease in RA patients. Although this contradiction was partly explained by the induction of tolerance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis of RA remain unknown. With regard to adiponectin's proinflammatory effects, we wondered whether adiponectin might stimulate the production of vascular endothelial growth factor (VEGF) and MMPs as well as proinflammatory mediators like IL-1beta and TNF-alpha do. In this study, we investigated the stimulatory effect of adiponectin on the production of IL-6, IL-8, prostaglandin E2 (PGE2), VEGF, and MMPs. In addition, the correlation between adiponectin and VEGF or MMPs was investigated by measuring the levels of these three proteins in the joint fluid of patients with RA or osteoarthritis (OA).

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[ "Cell", "Tissue", "Organism_substance", "Multi-tissue_structure" ]

muscle is a Organ, joint is a Multi-tissue_structure, body surface area is a Organism_subdivision, dermal is a Multi-tissue_structure, epidermal is a Multi-tissue_structure

PMID-21915357_task0

Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Multi-tissue_structure, Organism_subdivision, Organ

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Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.

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[ "Organism_subdivision", "Multi-tissue_structure", "Organ" ]

muscle is a Organ, joint is a Multi-tissue_structure, body surface area is a Organism_subdivision, dermal is a Multi-tissue_structure, epidermal is a Multi-tissue_structure

PMID-21915357_task1

Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please typing these entity words according to sentence: muscle, joint, body surface area, dermal, epidermal Options: Multi-tissue_structure, Organism_subdivision, Organ

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Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.

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[ "Organism_subdivision", "Multi-tissue_structure", "Organ" ]

muscle, joint, body surface area, dermal, epidermal

PMID-21915357_task2

Sentence: Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. Instructions: please extract entity words from the input sentence

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Burns from hot wheat bags: a public safety issue. Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3degreesC (135.1degreesF) when heated according to instructions, 63.3degreesC (145.9degreesF) in a 1000 W microwave and 69.6degreesC (157.3degreesF) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products.

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[ "Organism_subdivision", "Multi-tissue_structure", "Organ" ]

Iron is a CHEMICAL, zinc is a CHEMICAL, caseinophosphopeptides is a GENE-N, caseinophosphopeptides is a GENE-N, CPPs is a GENE-N, α(s)- and β - casein is a GENE-N, CN is a GENE-N, CPPs is a GENE-N, iron is a CHEMICAL, ferritin is a GENE-Y, zinc is a CHEMICAL, zinc is a CHEMICAL, α - CPP is a GENE-N, β - CPP is a GENE-N, ferritin is a GENE-Y, CPPs is a GENE-N, ferritin is a GENE-Y, iron sulphate is a CHEMICAL, zinc is a CHEMICAL, α - CPPs is a GENE-N, β - CPPs is a GENE-N, zinc is a CHEMICAL, zinc sulphate is a CHEMICAL

4262_task0

Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

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Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Iron is a CHEMICAL, zinc is a CHEMICAL, caseinophosphopeptides is a GENE-N, caseinophosphopeptides is a GENE-N, CPPs is a GENE-N, α(s)- and β - casein is a GENE-N, CN is a GENE-N, CPPs is a GENE-N, iron is a CHEMICAL, ferritin is a GENE-Y, zinc is a CHEMICAL, zinc is a CHEMICAL, α - CPP is a GENE-N, β - CPP is a GENE-N, ferritin is a GENE-Y, CPPs is a GENE-N, ferritin is a GENE-Y, iron sulphate is a CHEMICAL, zinc is a CHEMICAL, α - CPPs is a GENE-N, β - CPPs is a GENE-N, zinc is a CHEMICAL, zinc sulphate is a CHEMICAL

4262_task1

Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please typing these entity words according to sentence: Iron, zinc, caseinophosphopeptides, caseinophosphopeptides, CPPs, α(s)- and β - casein, CN, CPPs, iron, ferritin, zinc, zinc, α - CPP, β - CPP, ferritin, CPPs, ferritin, iron sulphate, zinc, α - CPPs, β - CPPs, zinc, zinc sulphate Options: GENE-Y, GENE-N, CHEMICAL

[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]

Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Iron, zinc, caseinophosphopeptides, caseinophosphopeptides, CPPs, α(s)- and β - casein, CN, CPPs, iron, ferritin, zinc, zinc, α - CPP, β - CPP, ferritin, CPPs, ferritin, iron sulphate, zinc, α - CPPs, β - CPPs, zinc, zinc sulphate

4262_task2

Sentence: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate. Instructions: please extract entity words from the input sentence

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Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides. A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Self Psychology is an umlsterm, analysis is an umlsterm, self is an umlsterm, empathy is an umlsterm, treatment is an umlsterm, patients is an umlsterm, disorder is an umlsterm, line is an umlsterm, self is an umlsterm, aggressive behaviour is an umlsterm, self is an umlsterm, self is an umlsterm, selfobject is an umlsterm, disorders is an umlsterm, self is an umlsterm, Selfobject is an umlsterm, lead is an umlsterm, forms is an umlsterm, transference is an umlsterm, Self Psychology is an umlsterm, therapeutic process is an umlsterm, infant is an umlsterm, research is an umlsterm, Self Psychology is an umlsterm, conflict is an umlsterm, survey is an umlsterm, Self Psychology is an umlsterm

Psychotherapeut.60410001.eng.abstr_task0

Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .

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[ "umlsterm" ]

Self Psychology is an umlsterm, analysis is an umlsterm, self is an umlsterm, empathy is an umlsterm, treatment is an umlsterm, patients is an umlsterm, disorder is an umlsterm, line is an umlsterm, self is an umlsterm, aggressive behaviour is an umlsterm, self is an umlsterm, self is an umlsterm, selfobject is an umlsterm, disorders is an umlsterm, self is an umlsterm, Selfobject is an umlsterm, lead is an umlsterm, forms is an umlsterm, transference is an umlsterm, Self Psychology is an umlsterm, therapeutic process is an umlsterm, infant is an umlsterm, research is an umlsterm, Self Psychology is an umlsterm, conflict is an umlsterm, survey is an umlsterm, Self Psychology is an umlsterm

Psychotherapeut.60410001.eng.abstr_task1

Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please typing these entity words according to sentence: Self Psychology, analysis, self, empathy, treatment, patients, disorder, line, self, aggressive behaviour, self, self, selfobject, disorders, self, Selfobject, lead, forms, transference, Self Psychology, therapeutic process, infant, research, Self Psychology, conflict, survey, Self Psychology Options: umlsterm

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Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .

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[ "umlsterm" ]

Self Psychology, analysis, self, empathy, treatment, patients, disorder, line, self, aggressive behaviour, self, self, selfobject, disorders, self, Selfobject, lead, forms, transference, Self Psychology, therapeutic process, infant, research, Self Psychology, conflict, survey, Self Psychology

Psychotherapeut.60410001.eng.abstr_task2

Sentence: Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology . Instructions: please extract entity words from the input sentence

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Psychoanalytic Self Psychology is presented as a postmodern paradigm for the analysis of the postpatriarchical self with the methodological approach of introspection and empathy . The limited possibilities of psychoanalytic treatment particularly with patients with a narcissistic disorder led Heinz Kohut to the hypothesis of a particular developmental line of narcissism and the motivational primacy of the self which he conceptualized as bipolar . Sexual and aggressive behaviour is subsequently seen as primary only if there is a coherent , vital and not fragmented self . Substantial conditions of self coherence are selfobject experiences , which are presented in their multiplicity as are disorders of the self . Selfobject experiences lead to the main forms of transference as seen by Psychoanalatic Self Psychology . A short synopsis of the therapeutic process and of the integration of infant research into Self Psychology as well as a different view of the oedipal conflict completes this survey together with some final remarks about a few new concepts in Psychoanalytic Self Psychology .

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[ "umlsterm" ]

thiazides is a GROUP, diuretics is a GROUP, corticosteroids is a GROUP, phenothiazines is a GROUP, thyroid products is a GROUP, estrogens is a GROUP, contraceptives is a GROUP, phenytoin is a DRUG, nicotinic acid is a DRUG, sympathomimetics is a GROUP, calcium channel - blocking drugs is a GROUP, isoniazid is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, sulfonylureas is a GROUP, insulin is a DRUG, Intestinal adsorbents is a GROUP, charcoal is a DRUG, digestive enzyme preparations is a GROUP, amylase is a DRUG, pancreatin is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, nifedipine is a DRUG, propranolol is a DRUG, ranitidine is a DRUG, Acarbose is a DRUG, sulfonylurea is a DRUG, glyburide is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG

Acarbose_ddi_task0

Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG

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Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.

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[ "GROUP", "DRUG" ]

thiazides is a GROUP, diuretics is a GROUP, corticosteroids is a GROUP, phenothiazines is a GROUP, thyroid products is a GROUP, estrogens is a GROUP, contraceptives is a GROUP, phenytoin is a DRUG, nicotinic acid is a DRUG, sympathomimetics is a GROUP, calcium channel - blocking drugs is a GROUP, isoniazid is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, sulfonylureas is a GROUP, insulin is a DRUG, Intestinal adsorbents is a GROUP, charcoal is a DRUG, digestive enzyme preparations is a GROUP, amylase is a DRUG, pancreatin is a DRUG, Acarbose is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, nifedipine is a DRUG, propranolol is a DRUG, ranitidine is a DRUG, Acarbose is a DRUG, sulfonylurea is a DRUG, glyburide is a DRUG, Acarbose is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG, Acarbose is a DRUG, metformin is a DRUG

Acarbose_ddi_task1

Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please typing these entity words according to sentence: thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel - blocking drugs, isoniazid, Acarbose, Acarbose, sulfonylureas, insulin, Intestinal adsorbents, charcoal, digestive enzyme preparations, amylase, pancreatin, Acarbose, Acarbose, digoxin, digoxin, Acarbose, digoxin, nifedipine, propranolol, ranitidine, Acarbose, sulfonylurea, glyburide, Acarbose, digoxin, digoxin, digoxin, digoxin, metformin, Acarbose, metformin, Acarbose, metformin, Acarbose, metformin Options: GROUP, DRUG

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Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.

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[ "GROUP", "DRUG" ]

thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel - blocking drugs, isoniazid, Acarbose, Acarbose, sulfonylureas, insulin, Intestinal adsorbents, charcoal, digestive enzyme preparations, amylase, pancreatin, Acarbose, Acarbose, digoxin, digoxin, Acarbose, digoxin, nifedipine, propranolol, ranitidine, Acarbose, sulfonylurea, glyburide, Acarbose, digoxin, digoxin, digoxin, digoxin, metformin, Acarbose, metformin, Acarbose, metformin, Acarbose, metformin

Acarbose_ddi_task2

Sentence: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Instructions: please extract entity words from the input sentence

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Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.

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[ "GROUP", "DRUG" ]

Ikaros gene is a DNA_domain_or_region, lymphocyte development and homeostasis is a (AND other_name other_name)

68502_task0

Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, (AND other_name other_name)

[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]

The role of the Ikaros gene in lymphocyte development and homeostasis.

[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]

Ikaros gene is a DNA_domain_or_region, lymphocyte development and homeostasis is a (AND other_name other_name)

68502_task1

Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please typing these entity words according to sentence: Ikaros gene, lymphocyte development and homeostasis Options: DNA_domain_or_region, (AND other_name other_name)

[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]

The role of the Ikaros gene in lymphocyte development and homeostasis.

[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]

Ikaros gene, lymphocyte development and homeostasis

68502_task2

Sentence: The role of the Ikaros gene in lymphocyte development and homeostasis. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "I-(AND other_name other_name)", "O" ]

The role of the Ikaros gene in lymphocyte development and homeostasis.

[ "The", "role", "of", "the", "Ikaros", "gene", "in", "lymphocyte", "development", "and", "homeostasis", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "(AND other_name other_name)", "cell_type", "other_name", "DNA_domain_or_region", "", "body_part", "protein_molecule" ]

biosensor is an umlsterm, technology is an umlsterm, measurement is an umlsterm, plasma is an umlsterm, concentrations is an umlsterm, critical care is an umlsterm, biosensor is an umlsterm, Diagnostics is an umlsterm, device is an umlsterm, goal is an umlsterm, methods is an umlsterm

DerAnaesthesist.80470968.eng.abstr_task0

Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .

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[ "umlsterm" ]

biosensor is an umlsterm, technology is an umlsterm, measurement is an umlsterm, plasma is an umlsterm, concentrations is an umlsterm, critical care is an umlsterm, biosensor is an umlsterm, Diagnostics is an umlsterm, device is an umlsterm, goal is an umlsterm, methods is an umlsterm

DerAnaesthesist.80470968.eng.abstr_task1

Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please typing these entity words according to sentence: biosensor, technology, measurement, plasma, concentrations, critical care, biosensor, Diagnostics, device, goal, methods Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .

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[ "umlsterm" ]

biosensor, technology, measurement, plasma, concentrations, critical care, biosensor, Diagnostics, device, goal, methods

DerAnaesthesist.80470968.eng.abstr_task2

Sentence: The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods . Instructions: please extract entity words from the input sentence

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The introduction of biosensor technology for near bedside measurement of plasma lactate concentrations has been a promising step for critical care profiling . However , methodological drawbacks and relevant inaccuracy have been reported . With the advent of a new biosensor ( Chiron Diagnostics ) and a revised NOVA Biomedical device , accuracy was expected to be improved . The goal of the present investigation was to evaluate the accuracy of both methods .

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[ "umlsterm" ]

Humangenetik is an umlsterm, Universitaet is an umlsterm, Goettingen is an umlsterm, Chromosomenanomalien is an umlsterm, Oestriol is an umlsterm, AFP is an umlsterm, Chromosomenanomalien is an umlsterm, Patientenkollektiv is an umlsterm, Verwendung is an umlsterm, Deutschland is an umlsterm, gestationsbezogene is an umlsterm, Fruchttod is an umlsterm, Hydrops fetalis is an umlsterm, X - chromosomale is an umlsterm, Ichthyose is an umlsterm, Spezifitaet is an umlsterm

Reproduktionsmedizin.90150276.ger.abstr_task0

Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .

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[ "umlsterm" ]

Humangenetik is an umlsterm, Universitaet is an umlsterm, Goettingen is an umlsterm, Chromosomenanomalien is an umlsterm, Oestriol is an umlsterm, AFP is an umlsterm, Chromosomenanomalien is an umlsterm, Patientenkollektiv is an umlsterm, Verwendung is an umlsterm, Deutschland is an umlsterm, gestationsbezogene is an umlsterm, Fruchttod is an umlsterm, Hydrops fetalis is an umlsterm, X - chromosomale is an umlsterm, Ichthyose is an umlsterm, Spezifitaet is an umlsterm

Reproduktionsmedizin.90150276.ger.abstr_task1

Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please typing these entity words according to sentence: Humangenetik, Universitaet, Goettingen, Chromosomenanomalien, Oestriol, AFP, Chromosomenanomalien, Patientenkollektiv, Verwendung, Deutschland, gestationsbezogene, Fruchttod, Hydrops fetalis, X - chromosomale, Ichthyose, Spezifitaet Options: umlsterm

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Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .

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[ "umlsterm" ]

Humangenetik, Universitaet, Goettingen, Chromosomenanomalien, Oestriol, AFP, Chromosomenanomalien, Patientenkollektiv, Verwendung, Deutschland, gestationsbezogene, Fruchttod, Hydrops fetalis, X - chromosomale, Ichthyose, Spezifitaet

Reproduktionsmedizin.90150276.ger.abstr_task2

Sentence: Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden . Instructions: please extract entity words from the input sentence

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Zwischen Ende 1989 und Anfang 1999 wurden am Institut fuer Humangenetik der Universitaet Goettingen 33 774 routinemaessige Untersuchungen zur Risikospezifizierung fetaler Chromosomenanomalien und Verschlussstoerungen auf der Grundlage des muetterlichen Altersrisikos und der Serumparameter humanes Choriongonadotropin ( hCG ) , unkonjugiertes Oestriol ( uE3) und Alpha-Fetoprotein ( AFP ) durchgefuehrt . Die prospektiv ermittelten Ergebnisse bestaetigen die Aussagen bisheriger retro- und prospektiver Studien zur Wertigkeit des sog . " Triple-Tests " . 54 fetale Chromosomenanomalien und 27 Verschlussstoerungen ( Neural- und Bauchwanddefekte ) wurden in diesem Patientenkollektiv unter Verwendung der in Deutschland ueblichen Grenzwerte erkannt . Es konnte festgestellt werden , dass ueber die eigentliche Zielgruppe hinaus regelmaessig weitere fetale und gestationsbezogene Stoerungen durch Extremwerte einzelner Serumparameter auffallen ( z . B. intrauteriner Fruchttod , Hydrops fetalis , X-chromosomale Ichthyose ) . Eigene Ergebnisse sowie Erkenntnisse zur Reduzierung systematischer Fehlerquellen und zur Verbesserung der Spezifitaet des Tests wurden gesammelt und sollen hier vorgestellt werden .

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[ "umlsterm" ]

Laryngektomie is an umlsterm, Narbensegels is an umlsterm, Schleimhauttasche is an umlsterm, Zungengrund is an umlsterm, Arbeit is an umlsterm, Aetiologie is an umlsterm, Patienten is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Divertikelbildung is an umlsterm, Radiotherapie is an umlsterm, Wundheilung is an umlsterm, Narbenschwellen is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Laryngektomie is an umlsterm, radiologisch is an umlsterm, laserchirurgische is an umlsterm, Therapie is an umlsterm

HNO.80460060.ger.abstr_task0

Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .

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[ "umlsterm" ]

Laryngektomie is an umlsterm, Narbensegels is an umlsterm, Schleimhauttasche is an umlsterm, Zungengrund is an umlsterm, Arbeit is an umlsterm, Aetiologie is an umlsterm, Patienten is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Divertikelbildung is an umlsterm, Radiotherapie is an umlsterm, Wundheilung is an umlsterm, Narbenschwellen is an umlsterm, Patienten is an umlsterm, Schluckstoerungen is an umlsterm, Laryngektomie is an umlsterm, radiologisch is an umlsterm, laserchirurgische is an umlsterm, Therapie is an umlsterm

HNO.80460060.ger.abstr_task1

Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please typing these entity words according to sentence: Laryngektomie, Narbensegels, Schleimhauttasche, Zungengrund, Arbeit, Aetiologie, Patienten, radiologisch, Patienten, Schluckstoerungen, Divertikelbildung, Radiotherapie, Wundheilung, Narbenschwellen, Patienten, Schluckstoerungen, Laryngektomie, radiologisch, laserchirurgische, Therapie Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .

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[ "umlsterm" ]

Laryngektomie, Narbensegels, Schleimhauttasche, Zungengrund, Arbeit, Aetiologie, Patienten, radiologisch, Patienten, Schluckstoerungen, Divertikelbildung, Radiotherapie, Wundheilung, Narbenschwellen, Patienten, Schluckstoerungen, Laryngektomie, radiologisch, laserchirurgische, Therapie

HNO.80460060.ger.abstr_task2

Sentence: Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Beim anterioren Pseudodivertikel nach Laryngektomie handelt es sich um eine ventral eines queren Narbensegels liegende Schleimhauttasche zwischen Zungengrund und Hypopharynxtrichter . Das Krankheitsbild hat bisher wenig Beachtung gefunden . Die vorliegende Arbeit untersucht , wie haeufig Pseudodivertikel auftreten , wie oft sie Beschwerden verursachen , welche therapeutischen Moeglichkeiten bestehen und ob sich Aussagen zur Aetiologie machen lassen . Zu diesem Zweck wurden 20 laryngektomierte Patienten hinsichtlich Schluckbeschwerden befragt sowie klinisch und radiologisch auf das Vorliegen eines Pseudodivertikels untersucht . Bei 11 der 20 Patienten fand sich ein Pseudodivertikel , welches in 9 Faellen Schluckstoerungen verursachte . Ein Zusammenhang zwischen Divertikelbildung und Radiotherapie respektive Verlauf der Wundheilung konnte nicht nachgewiesen werden . Alle 9 symptomatischen Narbenschwellen wurden endoskopisch mittels CO2-Laser durchtrennt . Dadurch liessen sich 8 der 9 Patienten von ihren Schluckbeschwerden befreien . Das anteriore Pseudodivertikel ist eine haeufige Ursache von Schluckstoerungen nach Laryngektomie . Es ist klinisch und radiologisch einfach zu diagnostizieren . Die endoskopische laserchirurgische Schwellendurchtrennung ist eine einfache und effiziente Therapie .

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[ "umlsterm" ]

surgical is an umlsterm, treatment is an umlsterm, diverticulum is an umlsterm, diverticula is an umlsterm, complication is an umlsterm, procedure is an umlsterm, surgical is an umlsterm, operation is an umlsterm, diverticulum is an umlsterm, treatment is an umlsterm, choice is an umlsterm, stage is an umlsterm

DerChirurg.90700753.eng.abstr_task0

Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .

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[ "umlsterm" ]

surgical is an umlsterm, treatment is an umlsterm, diverticulum is an umlsterm, diverticula is an umlsterm, complication is an umlsterm, procedure is an umlsterm, surgical is an umlsterm, operation is an umlsterm, diverticulum is an umlsterm, treatment is an umlsterm, choice is an umlsterm, stage is an umlsterm

DerChirurg.90700753.eng.abstr_task1

Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please typing these entity words according to sentence: surgical, treatment, diverticulum, diverticula, complication, procedure, surgical, operation, diverticulum, treatment, choice, stage Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .

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[ "umlsterm" ]

surgical, treatment, diverticulum, diverticula, complication, procedure, surgical, operation, diverticulum, treatment, choice, stage

DerChirurg.90700753.eng.abstr_task2

Sentence: The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

The classical surgical approach for the treatment of Zenker's diverticulum consists of diverticulectomy and cervical myotomy . In very small diverticula myotomy alone is sufficient . The complication rate of the procedure is tolerable . Long-term functional results are good in as much as 90 % and more . Despite the increasing importance of alternative approaches , the conventional extraluminal surgical operation for Zenker's diverticulum will remain the treatment of choice in stage I-III cases .

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[ "umlsterm" ]

Hormonersatztherapie is an umlsterm, Therapiezeiten is an umlsterm, Risiko is an umlsterm, Therapie is an umlsterm, Mammakarzinoms is an umlsterm, Praxis is an umlsterm, Oestrogenentzugs is an umlsterm

DerGynaekologe.00330402.ger.abstr_task0

Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .

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[ "umlsterm" ]

Hormonersatztherapie is an umlsterm, Therapiezeiten is an umlsterm, Risiko is an umlsterm, Therapie is an umlsterm, Mammakarzinoms is an umlsterm, Praxis is an umlsterm, Oestrogenentzugs is an umlsterm

DerGynaekologe.00330402.ger.abstr_task1

Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please typing these entity words according to sentence: Hormonersatztherapie, Therapiezeiten, Risiko, Therapie, Mammakarzinoms, Praxis, Oestrogenentzugs Options: umlsterm

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Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .

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[ "umlsterm" ]

Hormonersatztherapie, Therapiezeiten, Risiko, Therapie, Mammakarzinoms, Praxis, Oestrogenentzugs

DerGynaekologe.00330402.ger.abstr_task2

Sentence: Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam . Instructions: please extract entity words from the input sentence

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Die Hormonersatztherapie ( HRT ) fuehrt bis zu einer Anwendungsdauer von 5 Jahren zu keiner Erhoehung des Mammakarzinomrisikos . Laengere Therapiezeiten erhoehen das Risiko geringgradig . Obwohl der Nutzen einer langfristigen HRT nach dem derzeitigen Kenntisstand ueberwiegt , muss dieser Faktor im Rahmen der Aufklaerung der Patientinnen beruecksichtigt werden . Nach der Therapie des Mammakarzinoms gilt die HRT als grundsaetzlich kontraindiziert . Im Individualfall kann sie jedoch nach Ausschoepffung der Alternativen eingesetzt werden . In der Praxis betrifft dies vorwiegend die Gruppe von Patientinnen , die massiv unter den vegetativen und vasomotorischen Symptomen des Oestrogenentzugs leiden . In dieser Situation sind nicht-hormonale Alternativen meist wenig wirksam .

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[ "umlsterm" ]

Rechtsmedizin is an umlsterm, Hochschule is an umlsterm, Berufsrecht is an umlsterm, Rechtsmedizin is an umlsterm, Rechtsmedizin is an umlsterm, Befragung is an umlsterm, Befragung is an umlsterm, Organisation is an umlsterm

Rechtsmedizin.00100182.ger.abstr_task0

Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .

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[ "umlsterm" ]

Rechtsmedizin is an umlsterm, Hochschule is an umlsterm, Berufsrecht is an umlsterm, Rechtsmedizin is an umlsterm, Rechtsmedizin is an umlsterm, Befragung is an umlsterm, Befragung is an umlsterm, Organisation is an umlsterm

Rechtsmedizin.00100182.ger.abstr_task1

Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please typing these entity words according to sentence: Rechtsmedizin, Hochschule, Berufsrecht, Rechtsmedizin, Rechtsmedizin, Befragung, Befragung, Organisation Options: umlsterm

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Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .

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[ "umlsterm" ]

Rechtsmedizin, Hochschule, Berufsrecht, Rechtsmedizin, Rechtsmedizin, Befragung, Befragung, Organisation

Rechtsmedizin.00100182.ger.abstr_task2

Sentence: Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen . Instructions: please extract entity words from the input sentence

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Der Kurs Rechtsmedizin an der Medizinischen Hochschule Hannover sah im Wintersemester 1998/99 fuer jeden Studierenden 26 Pflichtstunden vor . Er bestand aus mehreren 2-stuendigen Seminaren und einer kursbegleitenden Vorlesung . Die Seminare hatten folgende Inhalte : Praktische Durchfuehrung einer Leichenschau , Teilnahme an einer Sektion mit Protokollerstellung und Nachbesprechung , Berufsrecht und -kunde sowie klinische Rechtsmedizin mit Verletzungsbegutachtung . Zusammen mit den zusaetzlichen Lehrangeboten umfasste die Lehre fuer das Fach Rechtsmedizin etwa 15 Semesterwochenstunden . Die Akzeptanz des Curriculums sollte durch eine Befragung der Studierenden ueberprueft werden . Von insgesamt 361 Studierenden beteiligten sich 72% an der Befragung . Auf einer Notenskala von 1-6 wurde der Kurs insgesamt mit der Durchschnittsnote 1,7 bewertet . Auf einer Skala von 1 ( = trifft nicht zu ) bis 7 ( = trifft zu ) wurden Aussagen zu Struktur und Inhalt von Vorlesungen und Seminaren eingeordnet . Mit einer durchschnittlichen Bewertung von ueber 6 Punkten wurden logischer Aufbau , Organisation , Anschaulichkeit und interessante Darbietung des Stoffes bewertet . Auch fuer die kommenden Semester ist eine kontinuierliche Lehrevaluation vorgesehen .

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[ "umlsterm" ]

Kopf - Hals - Tumoren is an umlsterm, Erweiterung is an umlsterm, Patienten is an umlsterm, Karzinomen is an umlsterm, Hypopharynx is an umlsterm, Larynx is an umlsterm, Speicheldruesen is an umlsterm, Klassifikation is an umlsterm, Tumoren is an umlsterm, Speicheldruesen is an umlsterm, rezidivfreien is an umlsterm, Eignung is an umlsterm, Prognoseunterschied is an umlsterm

HNO.90470957.ger.abstr_task0

Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .

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[ "umlsterm" ]

Kopf - Hals - Tumoren is an umlsterm, Erweiterung is an umlsterm, Patienten is an umlsterm, Karzinomen is an umlsterm, Hypopharynx is an umlsterm, Larynx is an umlsterm, Speicheldruesen is an umlsterm, Klassifikation is an umlsterm, Tumoren is an umlsterm, Speicheldruesen is an umlsterm, rezidivfreien is an umlsterm, Eignung is an umlsterm, Prognoseunterschied is an umlsterm

HNO.90470957.ger.abstr_task1

Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please typing these entity words according to sentence: Kopf - Hals - Tumoren, Erweiterung, Patienten, Karzinomen, Hypopharynx, Larynx, Speicheldruesen, Klassifikation, Tumoren, Speicheldruesen, rezidivfreien, Eignung, Prognoseunterschied Options: umlsterm

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Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .

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[ "umlsterm" ]

Kopf - Hals - Tumoren, Erweiterung, Patienten, Karzinomen, Hypopharynx, Larynx, Speicheldruesen, Klassifikation, Tumoren, Speicheldruesen, rezidivfreien, Eignung, Prognoseunterschied

HNO.90470957.ger.abstr_task2

Sentence: Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Zusammenfassung Die 5. Aufl. der TNM-Klassifikation bringt einige Aenderungen im Bereich der Kopf-Hals-Tumoren mit sich . Eine wesentliche Erweiterung der Stadiengruppierung besteht in der Unterteilung von Stadium IV in 3 Unterstadien . In einer retrospektiven Studie wurden die Krankheitsverlaeufe von 3247 Patienten mit Karzinomen der Mundhoehle , des Oro- und Hypopharynx , des Larynx , der Speicheldruesen und der Kieferhoehle ausgewertet . Hierbei kamen die 4. und die 5. Aufl. der TNM-Klassifikation vergleichend zur Anwendung . Insbesondere wurde geprueft , ob der Unterteilung von Stadium IV eine prognostische Relevanz zukommt . Bei der Klassifikation des Primaertumors ergaben sich die umfassendsten Aenderungen bei Tumoren der Supraglottis und der Speicheldruesen . Nach der 4. Aufl. der TNM-Klassifikation errechneten sich folgende rezidivfreien Fuenfjahresueberlebensraten : Stadium I 89,7% , Stadium II 78,9% , Stadium III 60,3% , Stadium IV 31,0% , nach der 5. Aufl. : Stadium I 90,8% , Stadium II 77,1% , Stadium III 61,3% , Stadium IVA 32,2% , Stadium IVB 25,8% , Stadium IVC 7,9% . Die Eignung der neuen Stadieneinteilung zur Schaffung einer prognostische Hierarchie konnte bestaetigt werden . Allerdings liess sich kein signifikanter Prognoseunterschied zwischen einer N2- ( Stadium IVA ) und einer N3-Metastasierung ( Stadium IVB ) finden .

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[ "umlsterm" ]

c - Jun N - terminal kinase is a Individual_protein, stress - activated protein kinase is a Individual_protein, JNK is a Individual_protein, SAPK is a Individual_protein, AP-1 is a Gene/protein/RNA

412_task0

Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]

In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.

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[ "Individual_protein", "Gene/protein/RNA" ]

c - Jun N - terminal kinase is a Individual_protein, stress - activated protein kinase is a Individual_protein, JNK is a Individual_protein, SAPK is a Individual_protein, AP-1 is a Gene/protein/RNA

412_task1

Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please typing these entity words according to sentence: c - Jun N - terminal kinase, stress - activated protein kinase, JNK, SAPK, AP-1 Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]

In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.

[ "In", "addition", ",", "we", "report", "that", "radiation", "induced", "transient", "activation", "of", "c", "-", "Jun", "N", "-", "terminal", "kinase", "/", "stress", "-", "activated", "protein", "kinase", "(", "JNK", "/", "SAPK", ")", "activation", "and", "the", "transcription", "factor", ",", "AP-1", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

c - Jun N - terminal kinase, stress - activated protein kinase, JNK, SAPK, AP-1

412_task2

Sentence: In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O" ]

In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1.

[ "In", "addition", ",", "we", "report", "that", "radiation", "induced", "transient", "activation", "of", "c", "-", "Jun", "N", "-", "terminal", "kinase", "/", "stress", "-", "activated", "protein", "kinase", "(", "JNK", "/", "SAPK", ")", "activation", "and", "the", "transcription", "factor", ",", "AP-1", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

heart is an umlsterm, epidemiological studies is an umlsterm, clinical trials is an umlsterm

ZfuerKardiologie.90880014.eng.abstr_task0

Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .

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[ "umlsterm" ]

heart is an umlsterm, epidemiological studies is an umlsterm, clinical trials is an umlsterm

ZfuerKardiologie.90880014.eng.abstr_task1

Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please typing these entity words according to sentence: heart, epidemiological studies, clinical trials Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .

[ "Background", ":", "Prognostic", "data", "heart", "failure", "rely", "on", "epidemiological", "studies", "or", "large", "clinical", "trials", ".", "These", "data", "are", "not", "to", "transfer", "easily", "on", "everyday", "practice", "." ]

[ "umlsterm" ]

heart, epidemiological studies, clinical trials

ZfuerKardiologie.90880014.eng.abstr_task2

Sentence: Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice .

[ "Background", ":", "Prognostic", "data", "heart", "failure", "rely", "on", "epidemiological", "studies", "or", "large", "clinical", "trials", ".", "These", "data", "are", "not", "to", "transfer", "easily", "on", "everyday", "practice", "." ]

[ "umlsterm" ]

Sprunggelenks is an umlsterm, Patienten is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, radiologischen is an umlsterm, Hauptdiagnose is an umlsterm, chronische Polyarthritis is an umlsterm, weiblichen is an umlsterm, Geschlechts is an umlsterm, STAR - Prothesen is an umlsterm, Roentgenanalyse is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, Prothesenlockerung is an umlsterm, Patient is an umlsterm, STAR - Prothesen is an umlsterm

DerOrthopaede.80270183.ger.abstr_task0

Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .

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[ "umlsterm" ]

Sprunggelenks is an umlsterm, Patienten is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, radiologischen is an umlsterm, Hauptdiagnose is an umlsterm, chronische Polyarthritis is an umlsterm, weiblichen is an umlsterm, Geschlechts is an umlsterm, STAR - Prothesen is an umlsterm, Roentgenanalyse is an umlsterm, zementfrei is an umlsterm, STAR - Prothesen is an umlsterm, Prothesenlockerung is an umlsterm, Patient is an umlsterm, STAR - Prothesen is an umlsterm

DerOrthopaede.80270183.ger.abstr_task1

Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please typing these entity words according to sentence: Sprunggelenks, Patienten, zementfrei, STAR - Prothesen, radiologischen, Hauptdiagnose, chronische Polyarthritis, weiblichen, Geschlechts, STAR - Prothesen, Roentgenanalyse, zementfrei, STAR - Prothesen, Prothesenlockerung, Patient, STAR - Prothesen Options: umlsterm

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Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .

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[ "umlsterm" ]

Sprunggelenks, Patienten, zementfrei, STAR - Prothesen, radiologischen, Hauptdiagnose, chronische Polyarthritis, weiblichen, Geschlechts, STAR - Prothesen, Roentgenanalyse, zementfrei, STAR - Prothesen, Prothesenlockerung, Patient, STAR - Prothesen

DerOrthopaede.80270183.ger.abstr_task2

Sentence: Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % . Instructions: please extract entity words from the input sentence

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Es werden die mittelfristigen Ergebnisse nach prothetischer Versorgung des Sprunggelenks vorgestellt ; 37 Patienten mit jeweils 20 zementiert verankerten Thompson-Richards-Prothesen und 19 zementfrei implantierten STAR-Prothesen konnten zwischen 1 und 12 Jahren postoperativ nachuntersucht werden . Die Nachuntersuchung basiert auf dem Kofoed-ankle-Score einschliesslich einer radiologischen Verlaufskontrolle . Die Hauptdiagnose war in beiden Kollektiven eine chronische Polyarthritis mit Dominanz des weiblichen Geschlechts . Zum Zeitpunkt der aktuellen Nachuntersuchung verbesserte sich der Gesamtscore fuer die STAR-Prothesen auf durchschnittlich 86,2 Punkte und fuer die Thompson-Richards-Prothesen auf 77,7 Punkte . Dies entspricht zu 94,7 bzw. 75 % einem guten bis sehr guten Gesamtergebnis . Die Roentgenanalyse zeigte einen hohen Prozentsatz an radiolucent lines " " insbesondere der tibialen Komponente der zementiert verankerten Thompson-Richards-Prothesen , bei einer revisionspflichtigen Lockerungsrate von 7,4 % . Die zementfrei implantierten STAR-Prothesen weisen lediglich in 15,8 % schmale " radiolucent lines " der tibialen Komponente auf . Eine Lockerung wurde nicht beobachtet ; 2 Thompson-Richards-Prothesen mussten aufgrund einer Prothesenlockerung revidiert werden . Zusaetzlich zog sich ein Patient postoperativ eine osteosynthesepflichtige Weber-C-Fraktur zu . Die kumulative Ueberlebensrate nach 12 Jahren betrug 87 % . Im Kollektiv der STAR-Prothesen wurden 2 Revisionen des Gleitkerns notwendig aufgrund eines Gleitkernbruchs bzw. einer primaer zu niedrig gewaehlten Gleitkernhoehe . Die kumulative Ueberlebensrate nach 6 Jahren betraegt 94,3 % .

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[ "umlsterm" ]

Zytokine is an umlsterm, Glukokortikoide is an umlsterm, Immunzellen is an umlsterm, Zellen is an umlsterm, Rolle is an umlsterm, Immunzellen is an umlsterm, Antigenen is an umlsterm

ZfuerRheumatologie.0059ii26.ger.abstr_task0

Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .

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[ "umlsterm" ]

Zytokine is an umlsterm, Glukokortikoide is an umlsterm, Immunzellen is an umlsterm, Zellen is an umlsterm, Rolle is an umlsterm, Immunzellen is an umlsterm, Antigenen is an umlsterm

ZfuerRheumatologie.0059ii26.ger.abstr_task1

Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please typing these entity words according to sentence: Zytokine, Glukokortikoide, Immunzellen, Zellen, Rolle, Immunzellen, Antigenen Options: umlsterm

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Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .

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[ "umlsterm" ]

Zytokine, Glukokortikoide, Immunzellen, Zellen, Rolle, Immunzellen, Antigenen

ZfuerRheumatologie.0059ii26.ger.abstr_task2

Sentence: Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen . Instructions: please extract entity words from the input sentence

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Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen .

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[ "umlsterm" ]

Classification systems is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, urodynamic is an umlsterm, classification is an umlsterm, function is an umlsterm, behaviour is an umlsterm, bladder is an umlsterm, bladder is an umlsterm, Society is an umlsterm, standardisation is an umlsterm, terminology is an umlsterm, urinary tract function is an umlsterm, standards is an umlsterm, terminology is an umlsterm, standards is an umlsterm, classification system is an umlsterm, classification is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, clinical investigation is an umlsterm, risks of is an umlsterm, disorder is an umlsterm

DerUrologeA.90380006.eng.abstr_task0

Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]

Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .

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[ "umlsterm" ]

Classification systems is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, urodynamic is an umlsterm, classification is an umlsterm, function is an umlsterm, behaviour is an umlsterm, bladder is an umlsterm, bladder is an umlsterm, Society is an umlsterm, standardisation is an umlsterm, terminology is an umlsterm, urinary tract function is an umlsterm, standards is an umlsterm, terminology is an umlsterm, standards is an umlsterm, classification system is an umlsterm, classification is an umlsterm, bladder is an umlsterm, dysfunction is an umlsterm, clinical investigation is an umlsterm, risks of is an umlsterm, disorder is an umlsterm

DerUrologeA.90380006.eng.abstr_task1

Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please typing these entity words according to sentence: Classification systems, bladder, dysfunction, urodynamic, classification, function, behaviour, bladder, bladder, Society, standardisation, terminology, urinary tract function, standards, terminology, standards, classification system, classification, bladder, dysfunction, clinical investigation, risks of, disorder Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]

Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .

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[ "umlsterm" ]

Classification systems, bladder, dysfunction, urodynamic, classification, function, behaviour, bladder, bladder, Society, standardisation, terminology, urinary tract function, standards, terminology, standards, classification system, classification, bladder, dysfunction, clinical investigation, risks of, disorder

DerUrologeA.90380006.eng.abstr_task2

Sentence: Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O" ]

Classification systems of bladder dysfunction are mainly based on functional and urodynamic characteristics . Under functional aspects classification relates to disturbances of storage and emptying function and the behaviour of its components , the bladder and the bladder outlet . The International Continence Society established a committee for the standardisation of terminology of lower urinary tract function and recommended worldwide accepted standards of terminology . These standards are the basis for any classification system and should be used to facilitate comparison of results . In addition , classification of bladder dysfunction should be completed by a clinical investigation to define the risks of underlaying disorder .

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[ "umlsterm" ]

anti - coagulation therapy is a Procedure, apart from is a Negation, rivaroxaban is a Drug, Hypersensitivity or allergy is a Scope, factor Xa inhibitors is a Drug, Acute bacterial endocarditis is a Condition, Bleeding disorder is a Condition, active bleeding is a Condition, Gastrointestinal ulcer is a Condition, Hepatic dysfunction is a Condition, increased is a Qualifier, bleeding risk is a Observation, Renal failure is a Condition, dialysis is a Procedure, Gastrectomy is a Procedure, biliopancreatic diversion is a Procedure, resection or re - routing is a Scope, small intestines is a Qualifier, Feeding tube is a Device, blood donation is a Observation, Abnormalities is a Value, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X is a Scope

NCT02970773_exc_task0

Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Observation, Procedure, Negation, Scope, Device, Drug

[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation

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[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]

anti - coagulation therapy is a Procedure, apart from is a Negation, rivaroxaban is a Drug, Hypersensitivity or allergy is a Scope, factor Xa inhibitors is a Drug, Acute bacterial endocarditis is a Condition, Bleeding disorder is a Condition, active bleeding is a Condition, Gastrointestinal ulcer is a Condition, Hepatic dysfunction is a Condition, increased is a Qualifier, bleeding risk is a Observation, Renal failure is a Condition, dialysis is a Procedure, Gastrectomy is a Procedure, biliopancreatic diversion is a Procedure, resection or re - routing is a Scope, small intestines is a Qualifier, Feeding tube is a Device, blood donation is a Observation, Abnormalities is a Value, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X is a Scope

NCT02970773_exc_task1

Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please typing these entity words according to sentence: anti - coagulation therapy, apart from, rivaroxaban, Hypersensitivity or allergy, factor Xa inhibitors, Acute bacterial endocarditis, Bleeding disorder, active bleeding, Gastrointestinal ulcer, Hepatic dysfunction, increased, bleeding risk, Renal failure, dialysis, Gastrectomy, biliopancreatic diversion, resection or re - routing, small intestines, Feeding tube, blood donation, Abnormalities, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X Options: Condition, Qualifier, Value, Observation, Procedure, Negation, Scope, Device, Drug

[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation

[ "Any", "anti", "-", "coagulation", "therapy", "(", "apart", "from", "rivaroxaban", "for", "second", "objective", ")", "\n", "Hypersensitivity", "or", "allergy", "to", "factor", "Xa", "inhibitors", "\n", "Acute", "bacterial", "endocarditis", "\n", "Bleeding", "disorder", "\n", "Clinically", "relevant", "active", "bleeding", "\n", "Gastrointestinal", "ulcer", "or", "tumor", "\n", "Hepatic", "dysfunction", "with", "increased", "bleeding", "risk", "\n", "Renal", "failure", "/", "patients", "undergoing", "dialysis", "\n", "Pregnancy", "and", "breast", "feeding", "\n", "Gastrectomy", ",", "biliopancreatic", "diversion", ",", "resection", "or", "re", "-", "routing", "of", "small", "intestines", "\n", "Feeding", "tube", "\n", "Recent", "blood", "donation", "\n", "Abnormalities", "of", "laboratory", "values", ":", "alanine", "-", "aminotransferase", "(", "ALAT", ")", ",", "aspartate", "-", "aminotransferase", "(", "ASAT", ")", ",", "gamma", "-", "glutamyl", "transferase", "(", "gammaGT", ")", ",", "alkalic", "phosphatase", "(", "AP", ")", ",", "bilirubin", ",", "amylase", ",", "lipase", ",", "cystatin", "C", ",", "creatinine", ",", "white", "blood", "cell", "count", ",", "haemoglobin", ",", "platelet", "count", ",", "prothrombin", "time", ",", "aPTT", ",", "fibrinogen", ",", "thrombin", "time", ",", "factors", "II", ",", "V", ",", "VII", "and", "X", "\n", "Use", "of", "therapeutic", "or", "recreational", "drugs", "influencing", "plasmatic", "coagulation", "\n" ]

[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]

anti - coagulation therapy, apart from, rivaroxaban, Hypersensitivity or allergy, factor Xa inhibitors, Acute bacterial endocarditis, Bleeding disorder, active bleeding, Gastrointestinal ulcer, Hepatic dysfunction, increased, bleeding risk, Renal failure, dialysis, Gastrectomy, biliopancreatic diversion, resection or re - routing, small intestines, Feeding tube, blood donation, Abnormalities, alanine - aminotransferase ( ALAT ) , aspartate - aminotransferase ( ASAT ) , gamma - glutamyl transferase ( gammaGT ) , alkalic phosphatase ( AP ) , bilirubin , amylase , lipase , cystatin C , creatinine , white blood cell count , haemoglobin , platelet count , prothrombin time , aPTT , fibrinogen , thrombin time , factors II , V , VII and X

NCT02970773_exc_task2

Sentence: Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation Instructions: please extract entity words from the input sentence

[ "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "O", "B-Device", "I-Device", "O", "O", "B-Observation", "I-Observation", "O", "B-Value", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Any anti-coagulation therapy (apart from rivaroxaban for second objective) Hypersensitivity or allergy to factor Xa inhibitors Acute bacterial endocarditis Bleeding disorder Clinically relevant active bleeding Gastrointestinal ulcer or tumor Hepatic dysfunction with increased bleeding risk Renal failure / patients undergoing dialysis Pregnancy and breast feeding Gastrectomy, biliopancreatic diversion, resection or re-routing of small intestines Feeding tube Recent blood donation Abnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X Use of therapeutic or recreational drugs influencing plasmatic coagulation

[ "Any", "anti", "-", "coagulation", "therapy", "(", "apart", "from", "rivaroxaban", "for", "second", "objective", ")", "\n", "Hypersensitivity", "or", "allergy", "to", "factor", "Xa", "inhibitors", "\n", "Acute", "bacterial", "endocarditis", "\n", "Bleeding", "disorder", "\n", "Clinically", "relevant", "active", "bleeding", "\n", "Gastrointestinal", "ulcer", "or", "tumor", "\n", "Hepatic", "dysfunction", "with", "increased", "bleeding", "risk", "\n", "Renal", "failure", "/", "patients", "undergoing", "dialysis", "\n", "Pregnancy", "and", "breast", "feeding", "\n", "Gastrectomy", ",", "biliopancreatic", "diversion", ",", "resection", "or", "re", "-", "routing", "of", "small", "intestines", "\n", "Feeding", "tube", "\n", "Recent", "blood", "donation", "\n", "Abnormalities", "of", "laboratory", "values", ":", "alanine", "-", "aminotransferase", "(", "ALAT", ")", ",", "aspartate", "-", "aminotransferase", "(", "ASAT", ")", ",", "gamma", "-", "glutamyl", "transferase", "(", "gammaGT", ")", ",", "alkalic", "phosphatase", "(", "AP", ")", ",", "bilirubin", ",", "amylase", ",", "lipase", ",", "cystatin", "C", ",", "creatinine", ",", "white", "blood", "cell", "count", ",", "haemoglobin", ",", "platelet", "count", ",", "prothrombin", "time", ",", "aPTT", ",", "fibrinogen", ",", "thrombin", "time", ",", "factors", "II", ",", "V", ",", "VII", "and", "X", "\n", "Use", "of", "therapeutic", "or", "recreational", "drugs", "influencing", "plasmatic", "coagulation", "\n" ]

[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Qualifier", "Observation", "Value", "Device", "Negation" ]

chemokine receptor CCR5 is a GENE-N

16298345_task0

Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]

Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.

[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

chemokine receptor CCR5 is a GENE-N

16298345_task1

Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please typing these entity words according to sentence: chemokine receptor CCR5 Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]

Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.

[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

chemokine receptor CCR5

16298345_task2

Sentence: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O" ]

Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.

[ "Molecular", "cloning", "and", "radioligand", "binding", "characterization", "of", "the", "chemokine", "receptor", "CCR5", "from", "rhesus", "macaque", "and", "human", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Na+/K+/2Cl- cotransporter is a GENE-N

10831596_task0

Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]

Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.

[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Na+/K+/2Cl- cotransporter is a GENE-N

10831596_task1

Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please typing these entity words according to sentence: Na+/K+/2Cl- cotransporter Options: GENE-N

[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]

Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.

[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Na+/K+/2Cl- cotransporter

10831596_task2

Sentence: Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O" ]

Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.

[ "Severe", "impairment", "of", "salivation", "in", "Na+/K+/2Cl-", "cotransporter", "(", "NKCC1)-deficient", "mice", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

kidney is a Organ, kidney is a Organ, T - cell is a Cell, kidney is a Organ

PMC-2690976-sec-05_task0

Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Organ, Cell

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.

[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]

[ "Organ", "Cell" ]

kidney is a Organ, kidney is a Organ, T - cell is a Cell, kidney is a Organ

PMC-2690976-sec-05_task1

Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please typing these entity words according to sentence: kidney, kidney, T - cell, kidney Options: Organ, Cell

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.

[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]

[ "Organ", "Cell" ]

kidney, kidney, T - cell, kidney

PMC-2690976-sec-05_task2

Sentence: Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Efficacy of MMF in current immunosuppressive regimens after kidney transplantation Current established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibodies) based on the immunologic risk of the recipient, followed by a maintenance regimen combining a CNI and an anti-proliferative agent, with or without corticosteroids.2-4 As MMF was the first MPA formulation approved in clinical kidney transplantation, more extensive clinical data are available with this drug in comparison to EC-MPS.

[ "Efficacy", "of", "MMF", "in", "current", "immunosuppressive", "regimens", "after", "kidney", "transplantation", "\n", "Current", "established", "immunosuppressive", "strategies", "in", "kidney", "transplantation", "often", "include", "an", "induction", "agent", "(", "monoclonal", "or", "polyclonal", "anti", "-", "T", "-", "cell", "antibodies", ")", "based", "on", "the", "immunologic", "risk", "of", "the", "recipient", ",", "followed", "by", "a", "maintenance", "regimen", "combining", "a", "CNI", "and", "an", "anti", "-", "proliferative", "agent", ",", "with", "or", "without", "corticosteroids.2", "-", "4", "As", "MMF", "was", "the", "first", "MPA", "formulation", "approved", "in", "clinical", "kidney", "transplantation", ",", "more", "extensive", "clinical", "data", "are", "available", "with", "this", "drug", "in", "comparison", "to", "EC", "-", "MPS", ".", "\n\n" ]

[ "Organ", "Cell" ]

man is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, cystectomy is an umlsterm, lymphadenectomy is an umlsterm, lymph nodes is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, lymph nodes is an umlsterm, symptoms is an umlsterm, plan is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, tumors is an umlsterm

DerUrologeA.00390572.eng.abstr_task0

Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .

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[ "umlsterm" ]

man is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, cystectomy is an umlsterm, lymphadenectomy is an umlsterm, lymph nodes is an umlsterm, mucin - positive is an umlsterm, carcinoma is an umlsterm, urachus is an umlsterm, lymph nodes is an umlsterm, symptoms is an umlsterm, plan is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, tumors is an umlsterm

DerUrologeA.00390572.eng.abstr_task1

Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please typing these entity words according to sentence: man, mucin - positive, carcinoma, urachus, cystectomy, lymphadenectomy, lymph nodes, mucin - positive, carcinoma, urachus, lymph nodes, symptoms, plan, diagnosis, treatment, tumors Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .

[ "We", "report", "on", "a", "44-year", "-", "old", "man", "with", "the", "rare", "case", "of", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", ".", "We", "performed", "extended", "partial", "cystectomy", "with", "regional", "staging", "lymphadenectomy", "of", "the", "obturator", "lymph", "nodes", ".", "Histological", "investigation", "revealed", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", "with", "negative", "lymph", "nodes", ".", "For", "this", "case", ",", "we", "present", "symptoms", ",", "a", "plan", "for", "diagnosis", ",", "and", "treatment", "of", "these", "tumors", "." ]

[ "umlsterm" ]

man, mucin - positive, carcinoma, urachus, cystectomy, lymphadenectomy, lymph nodes, mucin - positive, carcinoma, urachus, lymph nodes, symptoms, plan, diagnosis, treatment, tumors

DerUrologeA.00390572.eng.abstr_task2

Sentence: We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

We report on a 44-year-old man with the rare case of a mucin-positive carcinoma of the urachus . We performed extended partial cystectomy with regional staging lymphadenectomy of the obturator lymph nodes . Histological investigation revealed a mucin-positive carcinoma of the urachus with negative lymph nodes . For this case , we present symptoms , a plan for diagnosis , and treatment of these tumors .

[ "We", "report", "on", "a", "44-year", "-", "old", "man", "with", "the", "rare", "case", "of", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", ".", "We", "performed", "extended", "partial", "cystectomy", "with", "regional", "staging", "lymphadenectomy", "of", "the", "obturator", "lymph", "nodes", ".", "Histological", "investigation", "revealed", "a", "mucin", "-", "positive", "carcinoma", "of", "the", "urachus", "with", "negative", "lymph", "nodes", ".", "For", "this", "case", ",", "we", "present", "symptoms", ",", "a", "plan", "for", "diagnosis", ",", "and", "treatment", "of", "these", "tumors", "." ]

[ "umlsterm" ]

IL-10 is a Protein, IL-12 is a Protein, STAT4 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, OVA is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IFN - gamma is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein

97_task0

Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.

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[ "Protein" ]

IL-10 is a Protein, IL-12 is a Protein, STAT4 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-10 is a Protein, OVA is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein, CD4 is a Protein, IL-12 is a Protein, IFN - gamma is a Protein, IL-10 is a Protein, IL-10 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-10 is a Protein

97_task1

Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please typing these entity words according to sentence: IL-10, IL-12, STAT4, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, IL-12, IL-10, IL-10, IL-12, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, OVA, IL-12, IL-12, IL-10, CD4, IL-12, IFN - gamma, IL-10, IL-10, IL-12, IL-12, IL-10 Options: Protein

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IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.

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[ "Protein" ]

IL-10, IL-12, STAT4, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, IL-12, IL-10, IL-10, IL-12, IL-10, CD4, IL-12, IL-12, IL-10, IL-12, IL-10, OVA, IL-12, IL-12, IL-10, CD4, IL-12, IFN - gamma, IL-10, IL-10, IL-12, IL-12, IL-10

97_task2

Sentence: IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells. Instructions: please extract entity words from the input sentence

[ "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]

IL-10 Production Is Maintained by High TCR Signal Strength and IL-12 We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells. For this, CD4+ Tcells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A-4D). High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells. Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D). However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure4E). Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells. To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ Tcells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure4F). Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10. Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-gamma but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (FigureS4). Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.

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[ "Protein" ]

Trichostatin A is a CHEMICAL, transforming growth factor - β is a GENE-Y, oxygen is a CHEMICAL

23284002_task0

Sentence: Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.

[ "Trichostatin", "A", "inhibits", "transforming", "growth", "factor", "-", "β", "-", "induced", "reactive", "oxygen", "species", "accumulation", "and", "myofibroblast", "differentiation", "via", "enhanced", "NF", "-", "E2-related", "factor", "2-antioxidant", "response", "element", "signaling", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Trichostatin A is a CHEMICAL, transforming growth factor - β is a GENE-Y, oxygen is a CHEMICAL

23284002_task1

Sentence: Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. Instructions: please typing these entity words according to sentence: Trichostatin A, transforming growth factor - β, oxygen Options: GENE-Y, CHEMICAL

[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.

[ "Trichostatin", "A", "inhibits", "transforming", "growth", "factor", "-", "β", "-", "induced", "reactive", "oxygen", "species", "accumulation", "and", "myofibroblast", "differentiation", "via", "enhanced", "NF", "-", "E2-related", "factor", "2-antioxidant", "response", "element", "signaling", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]