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Trichostatin A, transforming growth factor - β, oxygen
23284002_task2
Sentence: Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. Instructions: please extract entity words from the input sentence
[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.
[ "Trichostatin", "A", "inhibits", "transforming", "growth", "factor", "-", "β", "-", "induced", "reactive", "oxygen", "species", "accumulation", "and", "myofibroblast", "differentiation", "via", "enhanced", "NF", "-", "E2-related", "factor", "2-antioxidant", "response", "element", "signaling", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Deutschland is an umlsterm, Kindes- is an umlsterm
DerGynaekologe.00330565.ger.abstr_task0
Sentence: Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden .
[ "Die", "Tetanuserkrankung", "mit", "einer", "Letalitaet", "von", "25", "%", "in", "Deutschland", "kann", "durch", "den", "Aufbau", "eines", "konsequenten", "Impfschutzes", "im", "Kindes-", "und", "Jugendalter", "und", "10-jaehrigen", "Auffrischimpfungen", "bei", "Erwachsenen", "sicher", "vermieden", "werden", "." ]
[ "umlsterm" ]
Deutschland is an umlsterm, Kindes- is an umlsterm
DerGynaekologe.00330565.ger.abstr_task1
Sentence: Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden . Instructions: please typing these entity words according to sentence: Deutschland, Kindes- Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden .
[ "Die", "Tetanuserkrankung", "mit", "einer", "Letalitaet", "von", "25", "%", "in", "Deutschland", "kann", "durch", "den", "Aufbau", "eines", "konsequenten", "Impfschutzes", "im", "Kindes-", "und", "Jugendalter", "und", "10-jaehrigen", "Auffrischimpfungen", "bei", "Erwachsenen", "sicher", "vermieden", "werden", "." ]
[ "umlsterm" ]
Deutschland, Kindes-
DerGynaekologe.00330565.ger.abstr_task2
Sentence: Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die Tetanuserkrankung mit einer Letalitaet von 25% in Deutschland kann durch den Aufbau eines konsequenten Impfschutzes im Kindes- und Jugendalter und 10-jaehrigen Auffrischimpfungen bei Erwachsenen sicher vermieden werden .
[ "Die", "Tetanuserkrankung", "mit", "einer", "Letalitaet", "von", "25", "%", "in", "Deutschland", "kann", "durch", "den", "Aufbau", "eines", "konsequenten", "Impfschutzes", "im", "Kindes-", "und", "Jugendalter", "und", "10-jaehrigen", "Auffrischimpfungen", "bei", "Erwachsenen", "sicher", "vermieden", "werden", "." ]
[ "umlsterm" ]
Brust is an umlsterm, Leben is an umlsterm, Sexualitaet is an umlsterm, weiblichen is an umlsterm, Verdachtsdiagnose is an umlsterm, Diagnose is an umlsterm, Mammakarzinoms is an umlsterm, Aengsten is an umlsterm, Mastektomie is an umlsterm, Persoenlichkeit is an umlsterm, Frau is an umlsterm, Lebensplanung is an umlsterm, Mammarekonstruktion is an umlsterm, Methode is an umlsterm, Lebensmodifikation is an umlsterm, Lebensqualitaet is an umlsterm, Frau is an umlsterm, Lokalrezidivs is an umlsterm, Mammarekonstruktion is an umlsterm, Mastektomie is an umlsterm
DerGynaekologe.90320114.ger.abstr_task0
Sentence: Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]
Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie .
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[ "umlsterm" ]
Brust is an umlsterm, Leben is an umlsterm, Sexualitaet is an umlsterm, weiblichen is an umlsterm, Verdachtsdiagnose is an umlsterm, Diagnose is an umlsterm, Mammakarzinoms is an umlsterm, Aengsten is an umlsterm, Mastektomie is an umlsterm, Persoenlichkeit is an umlsterm, Frau is an umlsterm, Lebensplanung is an umlsterm, Mammarekonstruktion is an umlsterm, Methode is an umlsterm, Lebensmodifikation is an umlsterm, Lebensqualitaet is an umlsterm, Frau is an umlsterm, Lokalrezidivs is an umlsterm, Mammarekonstruktion is an umlsterm, Mastektomie is an umlsterm
DerGynaekologe.90320114.ger.abstr_task1
Sentence: Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie . Instructions: please typing these entity words according to sentence: Brust, Leben, Sexualitaet, weiblichen, Verdachtsdiagnose, Diagnose, Mammakarzinoms, Aengsten, Mastektomie, Persoenlichkeit, Frau, Lebensplanung, Mammarekonstruktion, Methode, Lebensmodifikation, Lebensqualitaet, Frau, Lokalrezidivs, Mammarekonstruktion, Mastektomie Options: umlsterm
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Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie .
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[ "umlsterm" ]
Brust, Leben, Sexualitaet, weiblichen, Verdachtsdiagnose, Diagnose, Mammakarzinoms, Aengsten, Mastektomie, Persoenlichkeit, Frau, Lebensplanung, Mammarekonstruktion, Methode, Lebensmodifikation, Lebensqualitaet, Frau, Lokalrezidivs, Mammarekonstruktion, Mastektomie
DerGynaekologe.90320114.ger.abstr_task2
Sentence: Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie . Instructions: please extract entity words from the input sentence
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Die Brust gilt weit ueber ihre Bedeutung als Organ hinaus als sichtbares Symbol der Weiblichkeit , als Symbol fuer Leben und Sexualitaet und traegt entscheidend zur weiblichen Identitaet bei . Verdachtsdiagnose und gesicherte Diagnose eines Mammakarzinoms fuehren zu einer tiefen Bedrohung , Verunsicherung und zu Aengsten . Die Mastektomie bedeutet nicht nur koerperlich einen tiefen Einschnitt , sondern auch einen tiefen Einschnitt in die Persoenlichkeit der Frau und in ihre Lebensplanung . Generelle aber auch individuell-subjektive Reaktionen , koennen sich manifestieren . Die Mammarekonstruktion mit einer fuer die persoenlichen Gegebenheiten adaequaten Methode fuehrt ebenfalls mit individuellen Varianten zu einem Neubeginn , zu einer Lebensmodifikation , unterstuetzt Angstbewaeltigungsstrategien und birgt einen wesentlichen Anteil an der Lebensqualitaet der betroffenen Frau . Befuerchtungen wegen eines Lokalrezidivs , einer Metastasierung , einer Progredienz werden damit nicht selbstverstaendlich eliminiert , bleiben oft ueber Jahre als Begleiter " . " Dennoch kommt auch von psychologischer Seite ein eindeutiges , wenn nicht unkritisches Votum fuer die Mammarekonstruktion nach Mastektomie .
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[ "umlsterm" ]
thyroid hormone deiodinase is a GENE-N, OH - BDE is a CHEMICAL
23531416_task0
Sentence: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O" ]
Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages.
[ "Using", "whole", "mount", "in", "situ", "hybridization", "to", "examine", "thyroid", "hormone", "deiodinase", "expression", "in", "embryonic", "and", "larval", "zebrafish", ":", "A", "tool", "for", "examining", "OH", "-", "BDE", "toxicity", "to", "early", "life", "stages", "." ]
[ "CHEMICAL", "GENE-N", "GENE-Y" ]
thyroid hormone deiodinase is a GENE-N, OH - BDE is a CHEMICAL
23531416_task1
Sentence: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Instructions: please typing these entity words according to sentence: thyroid hormone deiodinase, OH - BDE Options: GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O" ]
Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages.
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[ "CHEMICAL", "GENE-N", "GENE-Y" ]
thyroid hormone deiodinase, OH - BDE
23531416_task2
Sentence: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O" ]
Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages.
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[ "CHEMICAL", "GENE-N", "GENE-Y" ]
tumoración is a MORFOLOGIA_NEOPLASIA, adenocarcinoma de tipo intestinal is a MORFOLOGIA_NEOPLASIA, neoplasia is a MORFOLOGIA_NEOPLASIA, metastásicas is a MORFOLOGIA_NEOPLASIA, adenocarcinoma moderadamente diferenciado is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, M0 is a MORFOLOGIA_NEOPLASIA, recidiva hepática is a MORFOLOGIA_NEOPLASIA, metastásicas is a MORFOLOGIA_NEOPLASIA, lesiones hepáticas is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, lesión en pene is a MORFOLOGIA_NEOPLASIA, Metástasis is a MORFOLOGIA_NEOPLASIA
941_task0
Sentence: Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución.
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[ "MORFOLOGIA_NEOPLASIA" ]
tumoración is a MORFOLOGIA_NEOPLASIA, adenocarcinoma de tipo intestinal is a MORFOLOGIA_NEOPLASIA, neoplasia is a MORFOLOGIA_NEOPLASIA, metastásicas is a MORFOLOGIA_NEOPLASIA, adenocarcinoma moderadamente diferenciado is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, M0 is a MORFOLOGIA_NEOPLASIA, recidiva hepática is a MORFOLOGIA_NEOPLASIA, metastásicas is a MORFOLOGIA_NEOPLASIA, lesiones hepáticas is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, lesión en pene is a MORFOLOGIA_NEOPLASIA, Metástasis is a MORFOLOGIA_NEOPLASIA
941_task1
Sentence: Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución. Instructions: please typing these entity words according to sentence: tumoración, adenocarcinoma de tipo intestinal, neoplasia, metastásicas, adenocarcinoma moderadamente diferenciado, tumoral, metástasis, M0, recidiva hepática, metastásicas, lesiones hepáticas, tumoración, lesión en pene, Metástasis Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución.
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[ "MORFOLOGIA_NEOPLASIA" ]
tumoración, adenocarcinoma de tipo intestinal, neoplasia, metastásicas, adenocarcinoma moderadamente diferenciado, tumoral, metástasis, M0, recidiva hepática, metastásicas, lesiones hepáticas, tumoración, lesión en pene, Metástasis
941_task2
Sentence: Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución. Instructions: please extract entity words from the input sentence
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Anamnesis Paciente varón de 63 años de edad que presenta una lesión no dolorosa durante la palpación en cara anterolateral del cuerpo del pene de un mes de evolución. Refiere desde hace un par de semanas dolor a diario, punzante e intermitente que le despierta por las noches en área perineal y peneana. Cede parcialmente con paracetamol. Mantiene micción conservada, sin uretrorragia. El paciente es portador de virus VIH desde hace 10 años. En tratamiento con efavirenz, emtricitabina y tenofovir, encontrándose con menos de 20 copias en último control. Como otros antecedentes médicos de interés, tuvo una infección por VHC recibiendo tratamiento curativo con respuesta viral sostenida y colitis ulcerosa en tratamiento con mesalazina. HISTORIA ONCOLÓGICA Dentro del programa de seguimiento por su colitis ulcerosa se realiza en junio de 2015 endoscopia digestiva baja y se evidencia una tumoración en sigma cuya anatomía patológica (AP) es compatible con adenocarcinoma de tipo intestinal. Se completa estudio con tomografía computarizada (TC) toracoabdominopélvica donde se observa un engrosamiento difuso de las paredes del sigma, con cambios grasos en la submucosa que indican colitis de larga evolución. Se visualiza pérdida del plano graso de separación del sigma, con respecto a la cúpula vesical, asociado a una única adenopatía en el mesosigma, que podrían estar en relación con la neoplasia de sigma. No se observan adenopatías, ni otras lesiones metastásicas o a distancia. En agosto 2015, se realizó una hemicolectomía izquierda. El informe AP de la pieza quirúrgica revela la presencia de adenocarcinoma moderadamente diferenciado de 4,5 x 4 cm que infiltra toda la pared intestinal hasta meso con afectación tumoral de rodete quirúrgico y 2 metástasis ganglionares, una de las cuales es masiva con ruptura capsular (pT3N1b M0). Inicia en septiembre 2015 quimioterapia adyuvante con FOLFOX (ácido folínico, fluorouracilo y oxaliplatino) recibiendo 12 ciclos y finalizando en febrero 2016. En diciembre de 2016, encontrándose el paciente asintomático, se constató recidiva hepática por 2 lesiones metastásicas en segmento VI del lóbulo hepático derecho que se trata con ablación por radiofrecuencia (RFA). En febrero de 2017, TC de control donde se observa necrosis completa de lesiones hepáticas con aparición de tumoración en espacio pararrectal izquierdo y valores de antígeno carcino-embrionario: 33,4 ng/ml (no fumadores 0-3 ng/ml. Fumadores 0-5 ng/ml.) Se realiza biopsia que confirma recidiva. BRAF, NRAS y KRAS nativos. Es tratada la recidiva pélvica con radio y quimioterapia concomitante con capecitabina, irradiándose el lecho mesorrectal y áreas ganglionares e iliacas internas (50Gy). Exploración física Buen estado general, performance status (PS) 0. Se observa lesión pétrea, no dolorosa en cara anterolateral derecha del cuerpo del pene. Se extiende hasta glande respetando a la palpación nivel proximal de cuerpos cavernosos. Asocia a su vez un nódulo indurado móvil inguinal derecho. Pruebas complementarias TC toracoabdominopélvica con contraste intravenoso en donde se observan lesiones blásticas de nueva aparición en ambas ramas isquiopúbicas. junto con una lesión en pene de 3,5 cm afectando a uretra y al cuerpo cavernoso del lado derecho. Diagnóstico Metástasis peneana de primario de sigma. Tratamiento Se comenta en comité de tumores y se instaura tratamiento de primera línea con FOLFIRI (ácido folínico, fluorouracilo y clorhidrato de irinotecán)-cetuximab. Evolución Tras la administración de dos ciclos de FOLFIRI-cetuximab, que tolera adecuadamente, presentando síntomas leves de náuseas y diarrea (G1), el paciente refiere mejoría significativa del dolor a nivel peneano y perineal encontrándose en buen estado general. Actualmente, está pendiente de administrarse el tercer ciclo y de evaluar evolución.
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[ "MORFOLOGIA_NEOPLASIA" ]
Stat 5b is a Protein, c - Kit is a Protein, Epo - R is a Protein, tyrosine is a Entity, Stat 5b is a Protein, c - Kit is a Protein, erythropoietin receptor is a Protein, Stat 5b is a Protein
621_task0
Sentence: Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
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Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.
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[ "Protein", "Entity" ]
Stat 5b is a Protein, c - Kit is a Protein, Epo - R is a Protein, tyrosine is a Entity, Stat 5b is a Protein, c - Kit is a Protein, erythropoietin receptor is a Protein, Stat 5b is a Protein
621_task1
Sentence: Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors. Instructions: please typing these entity words according to sentence: Stat 5b, c - Kit, Epo - R, tyrosine, Stat 5b, c - Kit, erythropoietin receptor, Stat 5b Options: Entity, Protein
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Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.
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[ "Protein", "Entity" ]
Stat 5b, c - Kit, Epo - R, tyrosine, Stat 5b, c - Kit, erythropoietin receptor, Stat 5b
621_task2
Sentence: Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors. Instructions: please extract entity words from the input sentence
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Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation. To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family. Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts. In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells. Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription. These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.
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[ "Protein", "Entity" ]
teleradiology is an umlsterm, cost - benefit analysis is an umlsterm, quantitative evaluations is an umlsterm, teleradiology is an umlsterm, qualitative evaluation is an umlsterm, costs is an umlsterm, savings is an umlsterm, value is an umlsterm, savings is an umlsterm, costs is an umlsterm, investment is an umlsterm, methods is an umlsterm, Savings is an umlsterm, time is an umlsterm
DerRadiologe.70370285.eng.abstr_task0
Sentence: With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems .
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[ "umlsterm" ]
teleradiology is an umlsterm, cost - benefit analysis is an umlsterm, quantitative evaluations is an umlsterm, teleradiology is an umlsterm, qualitative evaluation is an umlsterm, costs is an umlsterm, savings is an umlsterm, value is an umlsterm, savings is an umlsterm, costs is an umlsterm, investment is an umlsterm, methods is an umlsterm, Savings is an umlsterm, time is an umlsterm
DerRadiologe.70370285.eng.abstr_task1
Sentence: With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems . Instructions: please typing these entity words according to sentence: teleradiology, cost - benefit analysis, quantitative evaluations, teleradiology, qualitative evaluation, costs, savings, value, savings, costs, investment, methods, Savings, time Options: umlsterm
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With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems .
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[ "umlsterm" ]
teleradiology, cost - benefit analysis, quantitative evaluations, teleradiology, qualitative evaluation, costs, savings, value, savings, costs, investment, methods, Savings, time
DerRadiologe.70370285.eng.abstr_task2
Sentence: With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems . Instructions: please extract entity words from the input sentence
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With the increasing number of users and technical improvements , there are several application scenarios of teleradiology . To perform a cost-benefit analysis , an approach is presented , which focuses on both monetary and qualitative aspects . Process-related , qualitative and quantitative evaluations are described . The prestudy compares the radiological workflow before and after the introduction of a teleradiology system . A scoring model is part of the qualitative evaluation . The quantitative study focuses on costs and savings . Amortisation and a net present value of savings versus costs can be derived using dynamic investment methods . Savings can be achieved after a short time under ideal conditions , but there is no guarantee for a reimbursement for all systems .
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[ "umlsterm" ]
intensive regimen ( LNH-84 ) is a Intervention_Pharmacological, doxorubicin is a Intervention_Pharmacological, cyclophosphamide is a Intervention_Pharmacological, vindesine is a Intervention_Pharmacological, bleomycin is a Intervention_Pharmacological, prednisolone is a Intervention_Pharmacological, methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine is a Intervention_Pharmacological, cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone is a Intervention_Pharmacological, Four hundred forty - two patients is a Participant_Age, complete remission ( CR ) is a Outcome_Physical, partial remission is a Outcome_Physical, failed to respond is a Outcome_Physical, died is a Outcome_Mortality, overall survival time to failure ( TTF ) is a Outcome_Mortality, time to relapse ( TTR ) survival is a Outcome_Mortality, relapse rate is a Outcome_Physical, persistent fibronecrotic mass is a Outcome_Physical, relapse rate . is a Outcome_Physical, Toxicity is a Outcome_Adverse-effects, neutropenia is a Outcome_Adverse-effects, infection is a Outcome_Adverse-effects, dying from septic complications is a Outcome_Mortality, documented infection is a Outcome_Physical
65176_task0
Sentence: LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Participant_Age
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LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML .
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[ "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Age", "Outcome_Physical", "Outcome_Adverse-effects" ]
intensive regimen ( LNH-84 ) is a Intervention_Pharmacological, doxorubicin is a Intervention_Pharmacological, cyclophosphamide is a Intervention_Pharmacological, vindesine is a Intervention_Pharmacological, bleomycin is a Intervention_Pharmacological, prednisolone is a Intervention_Pharmacological, methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine is a Intervention_Pharmacological, cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone is a Intervention_Pharmacological, Four hundred forty - two patients is a Participant_Age, complete remission ( CR ) is a Outcome_Physical, partial remission is a Outcome_Physical, failed to respond is a Outcome_Physical, died is a Outcome_Mortality, overall survival time to failure ( TTF ) is a Outcome_Mortality, time to relapse ( TTR ) survival is a Outcome_Mortality, relapse rate is a Outcome_Physical, persistent fibronecrotic mass is a Outcome_Physical, relapse rate . is a Outcome_Physical, Toxicity is a Outcome_Adverse-effects, neutropenia is a Outcome_Adverse-effects, infection is a Outcome_Adverse-effects, dying from septic complications is a Outcome_Mortality, documented infection is a Outcome_Physical
65176_task1
Sentence: LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML . Instructions: please typing these entity words according to sentence: intensive regimen ( LNH-84 ), doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisolone, methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine, cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone, Four hundred forty - two patients, complete remission ( CR ), partial remission, failed to respond, died, overall survival time to failure ( TTF ), time to relapse ( TTR ) survival, relapse rate, persistent fibronecrotic mass, relapse rate ., Toxicity, neutropenia, infection, dying from septic complications, documented infection Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Participant_Age
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LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML .
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[ "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Age", "Outcome_Physical", "Outcome_Adverse-effects" ]
intensive regimen ( LNH-84 ), doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisolone, methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine, cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone, Four hundred forty - two patients, complete remission ( CR ), partial remission, failed to respond, died, overall survival time to failure ( TTF ), time to relapse ( TTR ) survival, relapse rate, persistent fibronecrotic mass, relapse rate ., Toxicity, neutropenia, infection, dying from septic complications, documented infection
65176_task2
Sentence: LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML . Instructions: please extract entity words from the input sentence
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LNH-84 regimen : a multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma . From July 1984 to September 1987 , 737 patients with aggressive malignant lymphoma ( ML ) were treated by an intensive regimen ( LNH-84 ) comprising three or four courses of doxorubicin , 75 mg/m2 ; cyclophosphamide , 1,200 mg/m2 ; vindesine , 2 mg/m2 x 2 ; bleomycin , 10 mg x 2 ; and prednisolone , 60 mg/m2 x 5 ( ACVB ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( AraCVmB ) . Four hundred forty-two patients had intermediate-grade ML , 221 highgrade ML , and 74 unclassified ML . Most of the patients had advanced disease : stage IIE ( 23 % ) , III ( 13 % ) , or IV ( 47 % ) ; 38 % disseminated nodes ; 38 % two or more extranodal sites ; and 41 % a tumoral mass greater than 10 cm . Five hundred fifty-three patients ( 75 % ) went into complete remission ( CR ) , 63 ( 9 % ) into partial remission , 62 ( 8 % ) failed to respond , and 59 ( 8 % ) died during ACVB courses , 17 of them from progression of the disease . With a median follow-up of 23 months , the estimated 2-year overall survival time to failure ( TTF ) , and time to relapse ( TTR ) survival are 67 % , 56 % , and 67 % , respectively . Patients receiving a late intensification had the same relapse rate as the other patients . A persistent fibronecrotic mass was found in 150 patients ( 20 % ) and did not influence the relapse rate . Toxicity was mainly neutropenia and infection during the ACVB courses , with 40 patients ( 5 % ) dying from septic complications while responding to treatment . Fifty-three percent of the patients had a neutropenia less than 0.500 x 10 ( 9 ) /L , 58 % fever ( 6 % grade 4 ) , and 49 % a documented infection ( 8 % grade 4 ) . These results obtained with the LNH-84 regimen demonstrate that this therapeutic scheme is an effective treatment for aggressive ML .
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[ "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Age", "Outcome_Physical", "Outcome_Adverse-effects" ]
radiotherapy is an umlsterm, tumor is an umlsterm, control is an umlsterm, survival is an umlsterm, patients is an umlsterm, rectal cancer is an umlsterm, patients is an umlsterm, rectal cancer is an umlsterm, surgery is an umlsterm, radiotherapy is an umlsterm, irradiation is an umlsterm, operation is an umlsterm, stage is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, irradiation is an umlsterm, methods is an umlsterm, operation is an umlsterm, amputation is an umlsterm, anterior is an umlsterm, survival rate is an umlsterm, control is an umlsterm, tumors is an umlsterm, irradiation is an umlsterm, survival rate is an umlsterm, radiotherapy is an umlsterm, radiotherapy is an umlsterm, overall is an umlsterm, survival is an umlsterm, recurrence is an umlsterm, tumor is an umlsterm, control is an umlsterm, rectal cancer is an umlsterm, radiation therapy is an umlsterm, survival rate is an umlsterm, radiotherapy is an umlsterm, surgery is an umlsterm
DerChirurg.80690759.eng.abstr_task0
Sentence: To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone .
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[ "umlsterm" ]
radiotherapy is an umlsterm, tumor is an umlsterm, control is an umlsterm, survival is an umlsterm, patients is an umlsterm, rectal cancer is an umlsterm, patients is an umlsterm, rectal cancer is an umlsterm, surgery is an umlsterm, radiotherapy is an umlsterm, irradiation is an umlsterm, operation is an umlsterm, stage is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, irradiation is an umlsterm, methods is an umlsterm, operation is an umlsterm, amputation is an umlsterm, anterior is an umlsterm, survival rate is an umlsterm, control is an umlsterm, tumors is an umlsterm, irradiation is an umlsterm, survival rate is an umlsterm, radiotherapy is an umlsterm, radiotherapy is an umlsterm, overall is an umlsterm, survival is an umlsterm, recurrence is an umlsterm, tumor is an umlsterm, control is an umlsterm, rectal cancer is an umlsterm, radiation therapy is an umlsterm, survival rate is an umlsterm, radiotherapy is an umlsterm, surgery is an umlsterm
DerChirurg.80690759.eng.abstr_task1
Sentence: To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone . Instructions: please typing these entity words according to sentence: radiotherapy, tumor, control, survival, patients, rectal cancer, patients, rectal cancer, surgery, radiotherapy, irradiation, operation, stage, patients, postoperative, irradiation, methods, operation, amputation, anterior, survival rate, control, tumors, irradiation, survival rate, radiotherapy, radiotherapy, overall, survival, recurrence, tumor, control, rectal cancer, radiation therapy, survival rate, radiotherapy, surgery Options: umlsterm
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To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone .
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[ "umlsterm" ]
radiotherapy, tumor, control, survival, patients, rectal cancer, patients, rectal cancer, surgery, radiotherapy, irradiation, operation, stage, patients, postoperative, irradiation, methods, operation, amputation, anterior, survival rate, control, tumors, irradiation, survival rate, radiotherapy, radiotherapy, overall, survival, recurrence, tumor, control, rectal cancer, radiation therapy, survival rate, radiotherapy, surgery
DerChirurg.80690759.eng.abstr_task2
Sentence: To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O" ]
To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer , a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery ( n = 46 ) or underwent preoperative radiotherapy with 5 x 3.3 Gy irradiation and operation within 48 h ( n = 47 ) . If indicated ( T4, UICC stage III ) patients also received postoperative irradiation . Comparison of the methods of operation ( abdominoperineal amputation versus anterior resection ) revealed no significant difference in 5-year survival rate ( P = 0.393 ) . Local control of R0-resected tumors was improved after preoperative irradiation ( P = 0.08 ) . The 5-year survival rate was significantly higher after preoperative short-term radiotherapy ( P = 0.027 ) . Preoperative radiotherapy is not an independent factor according to overall survival ( P = 0.078 ) and local recurrence ( P = 0.07 ) . In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy . The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone .
[ "To", "ascertain", "whether", "preoperative", "short", "-", "term", "radiotherapy", "can", "improve", "local", "tumor", "control", "and", "the", "long", "-", "term", "survival", "of", "patients", "with", "operable", "rectal", "cancer", ",", "a", "prospective", "randomised", "trial", "was", "performed", "from", "1988", "to", "1993", ".", "Ninety", "-", "three", "patients", "with", "rectal", "cancer", "were", "either", "directly", "treated", "with", "surgery", "(", "n", "=", "46", ")", "or", "underwent", "preoperative", "radiotherapy", "with", "5", "x", "3.3", "Gy", "irradiation", "and", "operation", "within", "48", "h", "(", "n", "=", "47", ")", ".", "If", "indicated", "(", "T4", ",", "UICC", "stage", "III", ")", "patients", "also", "received", "postoperative", "irradiation", ".", "Comparison", "of", "the", "methods", "of", "operation", "(", "abdominoperineal", "amputation", "versus", "anterior", "resection", ")", "revealed", "no", "significant", "difference", "in", "5-year", "survival", "rate", "(", "P", "=", "0.393", ")", ".", "Local", "control", "of", "R0-resected", "tumors", "was", "improved", "after", "preoperative", "irradiation", "(", "P", "=", "0.08", ")", ".", "The", "5-year", "survival", "rate", "was", "significantly", "higher", "after", "preoperative", "short", "-", "term", "radiotherapy", "(", "P", "=", "0.027", ")", ".", "Preoperative", "radiotherapy", "is", "not", "an", "independent", "factor", "according", "to", "overall", "survival", "(", "P", "=", "0.078", ")", "and", "local", "recurrence", "(", "P", "=", "0.07", ")", ".", "In", "agreement", "with", "the", "results", "of", "other", "authors", "the", "present", "study", "indicates", "improved", "local", "tumor", "control", "of", "rectal", "cancer", "after", "preoperative", "radiation", "therapy", ".", "The", "5-year", "survival", "rate", "was", "significantly", "better", "after", "preoperative", "radiotherapy", "than", "after", "surgery", "alone", "." ]
[ "umlsterm" ]
profilin is a Individual_protein, annexin I is a Individual_protein, profilin is a Individual_protein, annexin I is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein, annexin I is a Individual_protein
256_task0
Sentence: Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein
[ "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]
Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes.
[ "Effects", "of", "profilin", "-", "annexin", "I", "association", "on", "some", "properties", "of", "both", "profilin", "and", "annexin", "I", ":", "modification", "of", "the", "inhibitory", "activity", "of", "profilin", "on", "actin", "polymerization", "and", "inhibition", "of", "the", "self", "-", "association", "of", "annexin", "I", "and", "its", "interactions", "with", "liposomes", "." ]
[ "Individual_protein" ]
profilin is a Individual_protein, annexin I is a Individual_protein, profilin is a Individual_protein, annexin I is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein, annexin I is a Individual_protein
256_task1
Sentence: Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes. Instructions: please typing these entity words according to sentence: profilin, annexin I, profilin, annexin I, profilin, actin, annexin I Options: Individual_protein
[ "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]
Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes.
[ "Effects", "of", "profilin", "-", "annexin", "I", "association", "on", "some", "properties", "of", "both", "profilin", "and", "annexin", "I", ":", "modification", "of", "the", "inhibitory", "activity", "of", "profilin", "on", "actin", "polymerization", "and", "inhibition", "of", "the", "self", "-", "association", "of", "annexin", "I", "and", "its", "interactions", "with", "liposomes", "." ]
[ "Individual_protein" ]
profilin, annexin I, profilin, annexin I, profilin, actin, annexin I
256_task2
Sentence: Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]
Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes.
[ "Effects", "of", "profilin", "-", "annexin", "I", "association", "on", "some", "properties", "of", "both", "profilin", "and", "annexin", "I", ":", "modification", "of", "the", "inhibitory", "activity", "of", "profilin", "on", "actin", "polymerization", "and", "inhibition", "of", "the", "self", "-", "association", "of", "annexin", "I", "and", "its", "interactions", "with", "liposomes", "." ]
[ "Individual_protein" ]
Therapie is an umlsterm, Keratoconjunctivitis sicca is an umlsterm, Kiefer - Gesichts - Chirurgen is an umlsterm, Glandula submandibularis is an umlsterm
DerOpthalmologe.80950257.ger.abstr_task0
Sentence: Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ .
[ "Ziel", ":", "Die", "konservative", "Therapie", "schwerster", "Verlaeufe", "der", "Keratoconjunctivitis", "sicca", "(", "KCS", ")", "ist", "-", "insbesondere", "bei", "autoimmunologischer", "Grunderkrankung", "-", "oft", "frustran", "und", "teilweise", "trotz", "maximaler", "Substituatapplikation", "mit", "einem", "Fortschreiten", "der", "Sicca", "-", "bedingten", "Schaeden", "verbunden", ".", "In", "solchen", "Faellen", "kann", "die", "durch", "einen", "Kiefer", "-", "Gesichts", "-", "Chirurgen", "autolog", "transplantierte", "Glandula", "submandibularis", "GS", ")", "(", "als", "koerpereigene", "Substituatquelle", "genutzt", "werden", ".", "Wir", "berichten", "ueber", "unsere", "ophthalmologischen", "Erfahrungen", "mit", "diesem", "Verfahren", "im", "Zeitraum", "von", "bis", "zu", "2", "Jahren", "postoperativ", "." ]
[ "umlsterm" ]
Therapie is an umlsterm, Keratoconjunctivitis sicca is an umlsterm, Kiefer - Gesichts - Chirurgen is an umlsterm, Glandula submandibularis is an umlsterm
DerOpthalmologe.80950257.ger.abstr_task1
Sentence: Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ . Instructions: please typing these entity words according to sentence: Therapie, Keratoconjunctivitis sicca, Kiefer - Gesichts - Chirurgen, Glandula submandibularis Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ .
[ "Ziel", ":", "Die", "konservative", "Therapie", "schwerster", "Verlaeufe", "der", "Keratoconjunctivitis", "sicca", "(", "KCS", ")", "ist", "-", "insbesondere", "bei", "autoimmunologischer", "Grunderkrankung", "-", "oft", "frustran", "und", "teilweise", "trotz", "maximaler", "Substituatapplikation", "mit", "einem", "Fortschreiten", "der", "Sicca", "-", "bedingten", "Schaeden", "verbunden", ".", "In", "solchen", "Faellen", "kann", "die", "durch", "einen", "Kiefer", "-", "Gesichts", "-", "Chirurgen", "autolog", "transplantierte", "Glandula", "submandibularis", "GS", ")", "(", "als", "koerpereigene", "Substituatquelle", "genutzt", "werden", ".", "Wir", "berichten", "ueber", "unsere", "ophthalmologischen", "Erfahrungen", "mit", "diesem", "Verfahren", "im", "Zeitraum", "von", "bis", "zu", "2", "Jahren", "postoperativ", "." ]
[ "umlsterm" ]
Therapie, Keratoconjunctivitis sicca, Kiefer - Gesichts - Chirurgen, Glandula submandibularis
DerOpthalmologe.80950257.ger.abstr_task2
Sentence: Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ . Instructions: please extract entity words from the input sentence
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Ziel : Die konservative Therapie schwerster Verlaeufe der Keratoconjunctivitis sicca ( KCS ) ist - insbesondere bei autoimmunologischer Grunderkrankung - oft frustran und teilweise trotz maximaler Substituatapplikation mit einem Fortschreiten der Sicca-bedingten Schaeden verbunden . In solchen Faellen kann die durch einen Kiefer-Gesichts-Chirurgen autolog transplantierte Glandula submandibularis GS ) ( als koerpereigene Substituatquelle genutzt werden . Wir berichten ueber unsere ophthalmologischen Erfahrungen mit diesem Verfahren im Zeitraum von bis zu 2 Jahren postoperativ .
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[ "umlsterm" ]
Retinoblastoma is an umlsterm, function is an umlsterm, copies is an umlsterm, retinoblastoma is an umlsterm, susceptibility is an umlsterm, gene is an umlsterm, predisposition is an umlsterm, germline mutations is an umlsterm, gene is an umlsterm, Tumor is an umlsterm, allele is an umlsterm, patients is an umlsterm, tumors is an umlsterm, eyes is an umlsterm, disease is an umlsterm, mutations is an umlsterm, single is an umlsterm, tumor is an umlsterm, Knowledge is an umlsterm, germline mutation is an umlsterm, risk is an umlsterm, mutation is an umlsterm, germline mutations is an umlsterm, alleles is an umlsterm, translation is an umlsterm, nonsense mutations is an umlsterm, patients is an umlsterm, alleles is an umlsterm, penetrance is an umlsterm, tumor is an umlsterm, mutations is an umlsterm, protein is an umlsterm, Patients is an umlsterm, mutations is an umlsterm, tumor is an umlsterm, tumor is an umlsterm, penetrance is an umlsterm, penetrance is an umlsterm, patients is an umlsterm, cytogenetic is an umlsterm, mutation is an umlsterm, analysis is an umlsterm, DNA is an umlsterm, tumor is an umlsterm, blood is an umlsterm, germline mutations is an umlsterm, patients is an umlsterm, analysis is an umlsterm, patients is an umlsterm
DerOpthalmologe.70940263.eng.abstr_task0
Sentence: Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB .
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[ "umlsterm" ]
Retinoblastoma is an umlsterm, function is an umlsterm, copies is an umlsterm, retinoblastoma is an umlsterm, susceptibility is an umlsterm, gene is an umlsterm, predisposition is an umlsterm, germline mutations is an umlsterm, gene is an umlsterm, Tumor is an umlsterm, allele is an umlsterm, patients is an umlsterm, tumors is an umlsterm, eyes is an umlsterm, disease is an umlsterm, mutations is an umlsterm, single is an umlsterm, tumor is an umlsterm, Knowledge is an umlsterm, germline mutation is an umlsterm, risk is an umlsterm, mutation is an umlsterm, germline mutations is an umlsterm, alleles is an umlsterm, translation is an umlsterm, nonsense mutations is an umlsterm, patients is an umlsterm, alleles is an umlsterm, penetrance is an umlsterm, tumor is an umlsterm, mutations is an umlsterm, protein is an umlsterm, Patients is an umlsterm, mutations is an umlsterm, tumor is an umlsterm, tumor is an umlsterm, penetrance is an umlsterm, penetrance is an umlsterm, patients is an umlsterm, cytogenetic is an umlsterm, mutation is an umlsterm, analysis is an umlsterm, DNA is an umlsterm, tumor is an umlsterm, blood is an umlsterm, germline mutations is an umlsterm, patients is an umlsterm, analysis is an umlsterm, patients is an umlsterm
DerOpthalmologe.70940263.eng.abstr_task1
Sentence: Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB . Instructions: please typing these entity words according to sentence: Retinoblastoma, function, copies, retinoblastoma, susceptibility, gene, predisposition, germline mutations, gene, Tumor, allele, patients, tumors, eyes, disease, mutations, single, tumor, Knowledge, germline mutation, risk, mutation, germline mutations, alleles, translation, nonsense mutations, patients, alleles, penetrance, tumor, mutations, protein, Patients, mutations, tumor, tumor, penetrance, penetrance, patients, cytogenetic, mutation, analysis, DNA, tumor, blood, germline mutations, patients, analysis, patients Options: umlsterm
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Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB .
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[ "umlsterm" ]
Retinoblastoma, function, copies, retinoblastoma, susceptibility, gene, predisposition, germline mutations, gene, Tumor, allele, patients, tumors, eyes, disease, mutations, single, tumor, Knowledge, germline mutation, risk, mutation, germline mutations, alleles, translation, nonsense mutations, patients, alleles, penetrance, tumor, mutations, protein, Patients, mutations, tumor, tumor, penetrance, penetrance, patients, cytogenetic, mutation, analysis, DNA, tumor, blood, germline mutations, patients, analysis, patients
DerOpthalmologe.70940263.eng.abstr_task2
Sentence: Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB . Instructions: please extract entity words from the input sentence
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Retinoblastoma ( RB ) is initiated by loss of function of both copies of the retinoblastoma susceptibility gene ( RB 1 ) . Hereditary predisposition to RB is caused by germline mutations in the RB 1 gene . Tumor formation is initiated by the somatic loss of the second allele . Most patients with hereditary RB develop multiple tumors that usually affect both eyes . In nonhereditary disease , however , both RB 1 mutations are somatic events that cause the formation of a single tumor focus . Knowledge of the germline mutation is often essential for accurate risk prediction . Applying strategies for efficient mutation detection , germline mutations can be identified in most individuals with hereditary RB . The vast majority of mutant alleles cause premature termination of translation owing to frameshift or nonsense mutations . In patients carrying these mutant alleles , penetrance is almost complete ( > 95% ) and numerous tumor foci are observed . However , some 5% of the mutations result in comparatively mild alterations at the protein level . Patients with mutations of this kind often show a lower mean number of tumor foci ( reduced expressivity ) or no tumor at all ( incomplete penetrance ) . Reduced expressivity and incomplete penetrance are also observed in patients with large cytogenetic deletions . By mutation analysis in DNA from fresh frozen tumor samples and peripheral blood , we have detected RB 1 germline mutations in some 20% of patients with unilateral RB . These results emphasize the importance of molecular analysis in patients with isolated unilateral RB .
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[ "umlsterm" ]
Chlorhexidine - based antiseptic solution is a Intervention_Pharmacological, alcohol - based povidone - iodine is a Intervention_Pharmacological, chlorhexidine - based solutions is a Intervention_Pharmacological, catheter insertion sites is a Participant_Condition, catheter - related infection is a Outcome_Physical, central venous catheters is a Participant_Condition, 5 % povidone - iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . is a Intervention_Pharmacological, 538 is a Participant_Sample-size, 481 is a Participant_Sample-size, culture results is a Outcome_Other, incidence of catheter colonization is a Outcome_Adverse-effects, incidence density is a Outcome_Adverse-effects, catheter - related bloodstream infection is a Outcome_Adverse-effects, Chlorhexidine - based solutions is a Intervention_Pharmacological, povidone - iodine ( including alcohol - based ) formulations is a Intervention_Pharmacological
33180_task0
Sentence: Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection .
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[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
Chlorhexidine - based antiseptic solution is a Intervention_Pharmacological, alcohol - based povidone - iodine is a Intervention_Pharmacological, chlorhexidine - based solutions is a Intervention_Pharmacological, catheter insertion sites is a Participant_Condition, catheter - related infection is a Outcome_Physical, central venous catheters is a Participant_Condition, 5 % povidone - iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . is a Intervention_Pharmacological, 538 is a Participant_Sample-size, 481 is a Participant_Sample-size, culture results is a Outcome_Other, incidence of catheter colonization is a Outcome_Adverse-effects, incidence density is a Outcome_Adverse-effects, catheter - related bloodstream infection is a Outcome_Adverse-effects, Chlorhexidine - based solutions is a Intervention_Pharmacological, povidone - iodine ( including alcohol - based ) formulations is a Intervention_Pharmacological
33180_task1
Sentence: Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection . Instructions: please typing these entity words according to sentence: Chlorhexidine - based antiseptic solution, alcohol - based povidone - iodine, chlorhexidine - based solutions, catheter insertion sites, catheter - related infection, central venous catheters, 5 % povidone - iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol ., 538, 481, culture results, incidence of catheter colonization, incidence density, catheter - related bloodstream infection, Chlorhexidine - based solutions, povidone - iodine ( including alcohol - based ) formulations Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection .
[ "Chlorhexidine", "-", "based", "antiseptic", "solution", "vs", "alcohol", "-", "based", "povidone", "-", "iodine", "for", "central", "venous", "catheter", "care", ".", "BACKGROUND", "Although", "chlorhexidine", "-", "based", "solutions", "and", "alcohol", "-", "based", "povidone", "-", "iodine", "have", "been", "shown", "to", "be", "more", "efficient", "than", "aqueous", "povidone", "-", "iodine", "for", "skin", "disinfection", "at", "catheter", "insertion", "sites", ",", "their", "abilities", "to", "reduce", "catheter", "-", "related", "infection", "have", "never", "been", "compared", ".", "METHODS", "Consecutively", "scheduled", "central", "venous", "catheters", "inserted", "into", "jugular", "or", "subclavian", "veins", "were", "randomly", "assigned", "to", "be", "disinfected", "with", "5", "%", "povidone", "-", "iodine", "in", "70", "%", "ethanol", "or", "with", "a", "combination", "of", "0.25", "%", "chlorhexidine", "gluconate", ",", "0.025", "%", "benzalkonium", "chloride", ",", "and", "4", "%", "benzylic", "alcohol", ".", "Solutions", "were", "used", "for", "skin", "disinfection", "before", "catheter", "insertion", "(", "2", "consecutive", "30-second", "applications", "separated", "by", "a", "period", "sufficiently", "long", "to", "allow", "for", "dryness", ")", "and", "then", "as", "single", "applications", "during", "subsequent", "dressing", "changes", "(", "every", "72", "hours", ",", "or", "earlier", "if", "soiled", "or", "wet", ")", ".", "RESULTS", "Of", "538", "catheters", "randomized", ",", "481", "(", "89.4", "%", ")", "produced", "evaluable", "culture", "results", ".", "Compared", "with", "povidone", "-", "iodine", ",", "the", "chlorhexidine", "-", "based", "solution", "was", "associated", "with", "a", "50", "%", "decrease", "in", "the", "incidence", "of", "catheter", "colonization", "(", "11.6", "%", "vs", "22.2", "%", "[", "P", "=", ".002", "]", ";", "incidence", "density", ",", "9.7", "vs", "18.3", "per", "1000", "catheter", "-", "days", ")", "and", "with", "a", "trend", "toward", "lower", "rates", "of", "catheter", "-", "related", "bloodstream", "infection", "(", "1.7", "%", "vs", "4.2", "%", "[", "P", "=", ".09", "]", ";", "incidence", "density", ",", "1.4", "vs", "3.4", "per", "1000", "catheter", "-", "days", ")", ".", "Independent", "risk", "factors", "for", "catheter", "colonization", "were", "catheter", "insertion", "into", "the", "jugular", "vein", "(", "adjusted", "relative", "risk", ",", "2.01", ";", "95", "%", "confidence", "interval", ",", "1.24", "-", "3.24", ")", "and", "use", "of", "povidone", "-", "iodine", "(", "adjusted", "relative", "risk", ",", "1.87", ";", "95", "%", "confidence", "interval", ",", "1.18", "-", "2.96", ")", ".", "CONCLUSION", "Chlorhexidine", "-", "based", "solutions", "should", "be", "considered", "as", "a", "replacement", "for", "povidone", "-", "iodine", "(", "including", "alcohol", "-", "based", ")", "formulations", "in", "efforts", "to", "prevent", "catheter", "-", "related", "infection", "." ]
[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
Chlorhexidine - based antiseptic solution, alcohol - based povidone - iodine, chlorhexidine - based solutions, catheter insertion sites, catheter - related infection, central venous catheters, 5 % povidone - iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol ., 538, 481, culture results, incidence of catheter colonization, incidence density, catheter - related bloodstream infection, Chlorhexidine - based solutions, povidone - iodine ( including alcohol - based ) formulations
33180_task2
Sentence: Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection . Instructions: please extract entity words from the input sentence
[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care . BACKGROUND Although chlorhexidine-based solutions and alcohol-based povidone-iodine have been shown to be more efficient than aqueous povidone-iodine for skin disinfection at catheter insertion sites , their abilities to reduce catheter-related infection have never been compared . METHODS Consecutively scheduled central venous catheters inserted into jugular or subclavian veins were randomly assigned to be disinfected with 5 % povidone-iodine in 70 % ethanol or with a combination of 0.25 % chlorhexidine gluconate , 0.025 % benzalkonium chloride , and 4 % benzylic alcohol . Solutions were used for skin disinfection before catheter insertion ( 2 consecutive 30-second applications separated by a period sufficiently long to allow for dryness ) and then as single applications during subsequent dressing changes ( every 72 hours , or earlier if soiled or wet ) . RESULTS Of 538 catheters randomized , 481 ( 89.4 % ) produced evaluable culture results . Compared with povidone-iodine , the chlorhexidine-based solution was associated with a 50 % decrease in the incidence of catheter colonization ( 11.6 % vs 22.2 % [ P = .002 ] ; incidence density , 9.7 vs 18.3 per 1000 catheter-days ) and with a trend toward lower rates of catheter-related bloodstream infection ( 1.7 % vs 4.2 % [ P = .09 ] ; incidence density , 1.4 vs 3.4 per 1000 catheter-days ) . Independent risk factors for catheter colonization were catheter insertion into the jugular vein ( adjusted relative risk , 2.01 ; 95 % confidence interval , 1.24-3.24 ) and use of povidone-iodine ( adjusted relative risk , 1.87 ; 95 % confidence interval , 1.18-2.96 ) . CONCLUSION Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine ( including alcohol-based ) formulations in efforts to prevent catheter-related infection .
[ "Chlorhexidine", "-", "based", "antiseptic", "solution", "vs", "alcohol", "-", "based", "povidone", "-", "iodine", "for", "central", "venous", "catheter", "care", ".", "BACKGROUND", "Although", "chlorhexidine", "-", "based", "solutions", "and", "alcohol", "-", "based", "povidone", "-", "iodine", "have", "been", "shown", "to", "be", "more", "efficient", "than", "aqueous", "povidone", "-", "iodine", "for", "skin", "disinfection", "at", "catheter", "insertion", "sites", ",", "their", "abilities", "to", "reduce", "catheter", "-", "related", "infection", "have", "never", "been", "compared", ".", "METHODS", "Consecutively", "scheduled", "central", "venous", "catheters", "inserted", "into", "jugular", "or", "subclavian", "veins", "were", "randomly", "assigned", "to", "be", "disinfected", "with", "5", "%", "povidone", "-", "iodine", "in", "70", "%", "ethanol", "or", "with", "a", "combination", "of", "0.25", "%", "chlorhexidine", "gluconate", ",", "0.025", "%", "benzalkonium", "chloride", ",", "and", "4", "%", "benzylic", "alcohol", ".", "Solutions", "were", "used", "for", "skin", "disinfection", "before", "catheter", "insertion", "(", "2", "consecutive", "30-second", "applications", "separated", "by", "a", "period", "sufficiently", "long", "to", "allow", "for", "dryness", ")", "and", "then", "as", "single", "applications", "during", "subsequent", "dressing", "changes", "(", "every", "72", "hours", ",", "or", "earlier", "if", "soiled", "or", "wet", ")", ".", "RESULTS", "Of", "538", "catheters", "randomized", ",", "481", "(", "89.4", "%", ")", "produced", "evaluable", "culture", "results", ".", "Compared", "with", "povidone", "-", "iodine", ",", "the", "chlorhexidine", "-", "based", "solution", "was", "associated", "with", "a", "50", "%", "decrease", "in", "the", "incidence", "of", "catheter", "colonization", "(", "11.6", "%", "vs", "22.2", "%", "[", "P", "=", ".002", "]", ";", "incidence", "density", ",", "9.7", "vs", "18.3", "per", "1000", "catheter", "-", "days", ")", "and", "with", "a", "trend", "toward", "lower", "rates", "of", "catheter", "-", "related", "bloodstream", "infection", "(", "1.7", "%", "vs", "4.2", "%", "[", "P", "=", ".09", "]", ";", "incidence", "density", ",", "1.4", "vs", "3.4", "per", "1000", "catheter", "-", "days", ")", ".", "Independent", "risk", "factors", "for", "catheter", "colonization", "were", "catheter", "insertion", "into", "the", "jugular", "vein", "(", "adjusted", "relative", "risk", ",", "2.01", ";", "95", "%", "confidence", "interval", ",", "1.24", "-", "3.24", ")", "and", "use", "of", "povidone", "-", "iodine", "(", "adjusted", "relative", "risk", ",", "1.87", ";", "95", "%", "confidence", "interval", ",", "1.18", "-", "2.96", ")", ".", "CONCLUSION", "Chlorhexidine", "-", "based", "solutions", "should", "be", "considered", "as", "a", "replacement", "for", "povidone", "-", "iodine", "(", "including", "alcohol", "-", "based", ")", "formulations", "in", "efforts", "to", "prevent", "catheter", "-", "related", "infection", "." ]
[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
Bovine and ovine gonadotropin - releasing hormone ( GnRH)-II is a GENE-N, type II GnRH receptor is a GENE-N
16916952_task0
Sentence: Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N
[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.
[ "Bovine", "and", "ovine", "gonadotropin", "-", "releasing", "hormone", "(", "GnRH)-II", "ligand", "precursors", "and", "type", "II", "GnRH", "receptor", "genes", "are", "functionally", "inactivated", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Bovine and ovine gonadotropin - releasing hormone ( GnRH)-II is a GENE-N, type II GnRH receptor is a GENE-N
16916952_task1
Sentence: Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. Instructions: please typing these entity words according to sentence: Bovine and ovine gonadotropin - releasing hormone ( GnRH)-II, type II GnRH receptor Options: GENE-N
[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.
[ "Bovine", "and", "ovine", "gonadotropin", "-", "releasing", "hormone", "(", "GnRH)-II", "ligand", "precursors", "and", "type", "II", "GnRH", "receptor", "genes", "are", "functionally", "inactivated", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Bovine and ovine gonadotropin - releasing hormone ( GnRH)-II, type II GnRH receptor
16916952_task2
Sentence: Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. Instructions: please extract entity words from the input sentence
[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.
[ "Bovine", "and", "ovine", "gonadotropin", "-", "releasing", "hormone", "(", "GnRH)-II", "ligand", "precursors", "and", "type", "II", "GnRH", "receptor", "genes", "are", "functionally", "inactivated", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
hematopoietic development is an other_name, myeloid - committed eosinophil cell line is a cell_line, YJ is a cell_line, trilineage potential is an other_name
74277_task0
Sentence: Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_line, other_name
[ "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O", "B-cell_line", "O", "O", "B-other_name", "I-other_name", "O" ]
Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
[ "Models", "of", "lineage", "switching", "in", "hematopoietic", "development", ":", "a", "new", "myeloid", "-", "committed", "eosinophil", "cell", "line", "(", "YJ", ")", "demonstrates", "trilineage", "potential", "." ]
[ "cell_line", "other_name", "protein_family_or_group", "protein_molecule", "(OR cell_type cell_type)", "other_organic_compound", "cell_type", "cell_component", "RNA_molecule", "", "multi_cell", "RNA_family_or_group" ]
hematopoietic development is an other_name, myeloid - committed eosinophil cell line is a cell_line, YJ is a cell_line, trilineage potential is an other_name
74277_task1
Sentence: Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential. Instructions: please typing these entity words according to sentence: hematopoietic development, myeloid - committed eosinophil cell line, YJ, trilineage potential Options: cell_line, other_name
[ "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O", "B-cell_line", "O", "O", "B-other_name", "I-other_name", "O" ]
Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
[ "Models", "of", "lineage", "switching", "in", "hematopoietic", "development", ":", "a", "new", "myeloid", "-", "committed", "eosinophil", "cell", "line", "(", "YJ", ")", "demonstrates", "trilineage", "potential", "." ]
[ "cell_line", "other_name", "protein_family_or_group", "protein_molecule", "(OR cell_type cell_type)", "other_organic_compound", "cell_type", "cell_component", "RNA_molecule", "", "multi_cell", "RNA_family_or_group" ]
hematopoietic development, myeloid - committed eosinophil cell line, YJ, trilineage potential
74277_task2
Sentence: Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O", "B-cell_line", "O", "O", "B-other_name", "I-other_name", "O" ]
Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
[ "Models", "of", "lineage", "switching", "in", "hematopoietic", "development", ":", "a", "new", "myeloid", "-", "committed", "eosinophil", "cell", "line", "(", "YJ", ")", "demonstrates", "trilineage", "potential", "." ]
[ "cell_line", "other_name", "protein_family_or_group", "protein_molecule", "(OR cell_type cell_type)", "other_organic_compound", "cell_type", "cell_component", "RNA_molecule", "", "multi_cell", "RNA_family_or_group" ]
Verletzung is an umlsterm, oberen Extremitaet is an umlsterm, Ischaemie is an umlsterm, Gefaessverletzung is an umlsterm, Komplexverletzung is an umlsterm, Behandlung is an umlsterm, Fraktur is an umlsterm, Primaerbehandlung is an umlsterm, Komplexverletzungen is an umlsterm, Gelenksteife is an umlsterm, Ankylose is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Rehabilitation is an umlsterm, Ellenbogenfraktur is an umlsterm, Wiederherstellung is an umlsterm, Gelenks is an umlsterm, Therapieschritte is an umlsterm, Therapie is an umlsterm, Verletzungen is an umlsterm, oberen Extremitaet is an umlsterm, Gelenks is an umlsterm, Humerus is an umlsterm, Unterarm is an umlsterm, Gelenks is an umlsterm, Ulna is an umlsterm, Radiuskoepfchen is an umlsterm, Stabilisatoren is an umlsterm, Unterarms is an umlsterm, Verletzungen is an umlsterm, Diagnose is an umlsterm, Therapie is an umlsterm, Gefaessverletzung is an umlsterm, Ischaemiezeit is an umlsterm, Nervenverletzungen is an umlsterm, Rehabilitationsergebnis is an umlsterm, Therapie is an umlsterm, krankengymnastischer is an umlsterm, Verletzungen is an umlsterm
DerOrthopaede.70261020.ger.abstr_task0
Sentence: Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] .
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[ "umlsterm" ]
Verletzung is an umlsterm, oberen Extremitaet is an umlsterm, Ischaemie is an umlsterm, Gefaessverletzung is an umlsterm, Komplexverletzung is an umlsterm, Behandlung is an umlsterm, Fraktur is an umlsterm, Primaerbehandlung is an umlsterm, Komplexverletzungen is an umlsterm, Gelenksteife is an umlsterm, Ankylose is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Rehabilitation is an umlsterm, Ellenbogenfraktur is an umlsterm, Wiederherstellung is an umlsterm, Gelenks is an umlsterm, Therapieschritte is an umlsterm, Therapie is an umlsterm, Verletzungen is an umlsterm, oberen Extremitaet is an umlsterm, Gelenks is an umlsterm, Humerus is an umlsterm, Unterarm is an umlsterm, Gelenks is an umlsterm, Ulna is an umlsterm, Radiuskoepfchen is an umlsterm, Stabilisatoren is an umlsterm, Unterarms is an umlsterm, Verletzungen is an umlsterm, Diagnose is an umlsterm, Therapie is an umlsterm, Gefaessverletzung is an umlsterm, Ischaemiezeit is an umlsterm, Nervenverletzungen is an umlsterm, Rehabilitationsergebnis is an umlsterm, Therapie is an umlsterm, krankengymnastischer is an umlsterm, Verletzungen is an umlsterm
DerOrthopaede.70261020.ger.abstr_task1
Sentence: Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] . Instructions: please typing these entity words according to sentence: Verletzung, oberen Extremitaet, Ischaemie, Gefaessverletzung, Komplexverletzung, Behandlung, Fraktur, Primaerbehandlung, Komplexverletzungen, Gelenksteife, Ankylose, Behandlung, Patienten, Rehabilitation, Ellenbogenfraktur, Wiederherstellung, Gelenks, Therapieschritte, Therapie, Verletzungen, oberen Extremitaet, Gelenks, Humerus, Unterarm, Gelenks, Ulna, Radiuskoepfchen, Stabilisatoren, Unterarms, Verletzungen, Diagnose, Therapie, Gefaessverletzung, Ischaemiezeit, Nervenverletzungen, Rehabilitationsergebnis, Therapie, krankengymnastischer, Verletzungen Options: umlsterm
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Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] .
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[ "umlsterm" ]
Verletzung, oberen Extremitaet, Ischaemie, Gefaessverletzung, Komplexverletzung, Behandlung, Fraktur, Primaerbehandlung, Komplexverletzungen, Gelenksteife, Ankylose, Behandlung, Patienten, Rehabilitation, Ellenbogenfraktur, Wiederherstellung, Gelenks, Therapieschritte, Therapie, Verletzungen, oberen Extremitaet, Gelenks, Humerus, Unterarm, Gelenks, Ulna, Radiuskoepfchen, Stabilisatoren, Unterarms, Verletzungen, Diagnose, Therapie, Gefaessverletzung, Ischaemiezeit, Nervenverletzungen, Rehabilitationsergebnis, Therapie, krankengymnastischer, Verletzungen
DerOrthopaede.70261020.ger.abstr_task2
Sentence: Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] . Instructions: please extract entity words from the input sentence
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Das komplexe Ellenbogentrauma ist gekennzeichnet durch eine serielle Verletzung der oberen Extremitaet oder einen schweren ausgedehnten Weichteilschaden oder durch eine verlaengerte Ischaemie , bedingt durch eine Gefaessverletzung oder durch ein Kompartmentsyndrom . Sie gelten daher als Komplexverletzung , da ihre Behandlung von der einer einfachen Fraktur abweicht und somit standardisierte Konzepte sich nicht anwenden lassen . Die Ergebnisse der Primaerbehandlung von Komplexverletzungen weisen eine hohe Komplikationsrate auf . Diese sind mit Funktionsdefiziten vergesellschaftet , die bis zur vollstaendigen posttraumatischen Gelenksteife ( Ankylose ) reichen koennen [ 2 8 ] . , Eine fehlerhafte Behandlung bedeutet fuer den Patienten immer eine verzoegerte Rehabilitation mit meist zahlreichen Sekundaereingriffen . Die operative Versorgung der komplexen Ellenbogenfraktur stellt eine Herausforderung an den Operateur dar . Das oberste Prinzip ist die Wiederherstellung des Gelenks und damit der Funktion . Daher ist der logistische Ablauf einzelner Therapieschritte fuer eine optimale Versorgung von besonderer Bedeutung [ 9 ] . Bei der primaeren operativen Therapie ist moeglichst eine definitive Versorgung aller Verletzungen der oberen Extremitaet anzustreben . Eine stabile Osteosynthese ermoeglicht die rasche Mobilisierung . Eine Transfixation des Gelenks ist nur in Ausnahmefaellen gerechtfertigt . Im Bereich des distalen Humerus haben sich , wie auch am proximalen Unterarm , die Prinzipien der AO bewaehrt . Fuer eine adaequate Rekonstruktion des Gelenks sind haeufig erweiterte operative Zugaenge angezeigt [ 2 , 9 , 18 ] . Bei der Versorgung der proximalen Ulna haben sich indirekte Repositionstechniken etabliert . Radiuskoepfchen und Koronoid stellen wichtige dynamische Stabilisatoren dar [ 16 ] . Bei der Weichteilversorgung sind meist nur lokal rekonstruktive Massnahmen erforderlich . Die Indikation zur Kompartmentspaltung des Unterarms sollte bei diesen Verletzungen grosszuegig gestellt werden . Die Diagnose und Therapie einer begleitenden Gefaessverletzung sollte aufgrund der sonst resultierenden prolongierten Ischaemiezeit rasch erfolgen . Bei den Nervenverletzungen ist eine initiale operative Versorgung nur im Einzelfall ( bei scharfer Durchtrennung ) angezeigt , ansonsten erfolgt eine sekundaere Versorgung im Intervall nach fruehestens 3 Monaten . Das Rehabilitationsergebnis ist von der primaeren Therapie abhaengig . Nur bei rascher Mobilisierung und intensiver krankengymnastischer Anleitung kann bei diesen schweren Verletzungen ein zufriedenstellendes Ergebnis erzielt werden . Die Indikation zu einer geplanten Arthrolyse sollte grosszuegig gestellt werden und ggf. mit einer Teilimplantatentfernung nach 4-6 Monaten erfolgen [ 2 ] .
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[ "umlsterm" ]
ASA is a Measurement, III y IV is a Value, Chronic pain is a Condition, alcohol abuse is a Condition, Chronic use is a Multiplier, opioid and sedatives is a Scope, Neuropsychiatric illness is a Condition, NSAID and other analgesics is a Scope, 48 hours previous to the surgery is a Temporal, CMI is a Measurement
NCT02992938_exc_task0
Sentence: Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30 Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Multiplier, Scope, Measurement
[ "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Multiplier", "I-Multiplier", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Measurement", "O", "O", "O" ]
Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30
[ "Patients", "ASA", "III", "y", "IV", "\n", "Chronic", "pain", "history", "\n", "Drug", "and", "alcohol", "abuse", "\n", "Chronic", "use", "of", "opioid", "and", "sedatives", "\n", "Neuropsychiatric", "illness", "\n", "NSAID", "and", "other", "analgesics", "used", "the", "48", "hours", "previous", "to", "the", "surgery", "\n", "CMI", ">", "30", "\n" ]
[ "Temporal", "Scope", "Condition", "Multiplier", "Reference_point", "Drug", "Value", "Qualifier", "Measurement" ]
ASA is a Measurement, III y IV is a Value, Chronic pain is a Condition, alcohol abuse is a Condition, Chronic use is a Multiplier, opioid and sedatives is a Scope, Neuropsychiatric illness is a Condition, NSAID and other analgesics is a Scope, 48 hours previous to the surgery is a Temporal, CMI is a Measurement
NCT02992938_exc_task1
Sentence: Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30 Instructions: please typing these entity words according to sentence: ASA, III y IV, Chronic pain, alcohol abuse, Chronic use, opioid and sedatives, Neuropsychiatric illness, NSAID and other analgesics, 48 hours previous to the surgery, CMI Options: Temporal, Condition, Value, Multiplier, Scope, Measurement
[ "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Multiplier", "I-Multiplier", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Measurement", "O", "O", "O" ]
Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30
[ "Patients", "ASA", "III", "y", "IV", "\n", "Chronic", "pain", "history", "\n", "Drug", "and", "alcohol", "abuse", "\n", "Chronic", "use", "of", "opioid", "and", "sedatives", "\n", "Neuropsychiatric", "illness", "\n", "NSAID", "and", "other", "analgesics", "used", "the", "48", "hours", "previous", "to", "the", "surgery", "\n", "CMI", ">", "30", "\n" ]
[ "Temporal", "Scope", "Condition", "Multiplier", "Reference_point", "Drug", "Value", "Qualifier", "Measurement" ]
ASA, III y IV, Chronic pain, alcohol abuse, Chronic use, opioid and sedatives, Neuropsychiatric illness, NSAID and other analgesics, 48 hours previous to the surgery, CMI
NCT02992938_exc_task2
Sentence: Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30 Instructions: please extract entity words from the input sentence
[ "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Multiplier", "I-Multiplier", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Measurement", "O", "O", "O" ]
Patients ASA III y IV Chronic pain history Drug and alcohol abuse Chronic use of opioid and sedatives Neuropsychiatric illness NSAID and other analgesics used the 48 hours previous to the surgery CMI > 30
[ "Patients", "ASA", "III", "y", "IV", "\n", "Chronic", "pain", "history", "\n", "Drug", "and", "alcohol", "abuse", "\n", "Chronic", "use", "of", "opioid", "and", "sedatives", "\n", "Neuropsychiatric", "illness", "\n", "NSAID", "and", "other", "analgesics", "used", "the", "48", "hours", "previous", "to", "the", "surgery", "\n", "CMI", ">", "30", "\n" ]
[ "Temporal", "Scope", "Condition", "Multiplier", "Reference_point", "Drug", "Value", "Qualifier", "Measurement" ]
psychopathology is an umlsterm, patients is an umlsterm, Therapeutic is an umlsterm, goals is an umlsterm, therapeutic is an umlsterm, attitudes is an umlsterm, treatment is an umlsterm
Psychotherapeut.60410077.eng.abstr_task0
Sentence: The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example .
[ "The", "psychopathology", "of", "structurally", "disordered", "patients", "is", "briefly", "described", ".", "Therapeutic", "goals", ",", "basic", "therapeutic", "attitudes", ",", "and", "principles", "of", "intervention", "in", "psychoanalytic", "-", "interactional", "treatment", "are", "discussed", "in", "detail", ".", "This", "is", "illustrated", "with", "a", "brief", "case", "example", "." ]
[ "umlsterm" ]
psychopathology is an umlsterm, patients is an umlsterm, Therapeutic is an umlsterm, goals is an umlsterm, therapeutic is an umlsterm, attitudes is an umlsterm, treatment is an umlsterm
Psychotherapeut.60410077.eng.abstr_task1
Sentence: The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example . Instructions: please typing these entity words according to sentence: psychopathology, patients, Therapeutic, goals, therapeutic, attitudes, treatment Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example .
[ "The", "psychopathology", "of", "structurally", "disordered", "patients", "is", "briefly", "described", ".", "Therapeutic", "goals", ",", "basic", "therapeutic", "attitudes", ",", "and", "principles", "of", "intervention", "in", "psychoanalytic", "-", "interactional", "treatment", "are", "discussed", "in", "detail", ".", "This", "is", "illustrated", "with", "a", "brief", "case", "example", "." ]
[ "umlsterm" ]
psychopathology, patients, Therapeutic, goals, therapeutic, attitudes, treatment
Psychotherapeut.60410077.eng.abstr_task2
Sentence: The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The psychopathology of structurally disordered patients is briefly described . Therapeutic goals , basic therapeutic attitudes , and principles of intervention in psychoanalytic-interactional treatment are discussed in detail . This is illustrated with a brief case example .
[ "The", "psychopathology", "of", "structurally", "disordered", "patients", "is", "briefly", "described", ".", "Therapeutic", "goals", ",", "basic", "therapeutic", "attitudes", ",", "and", "principles", "of", "intervention", "in", "psychoanalytic", "-", "interactional", "treatment", "are", "discussed", "in", "detail", ".", "This", "is", "illustrated", "with", "a", "brief", "case", "example", "." ]
[ "umlsterm" ]
CK1epsilon is a protein, dsh is a protein, GBP is a protein, Xenopus is an organism
1.0alpha7.train.1396_task0
Sentence: CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: organism, protein
[ "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "B-organism", "O", "O" ]
CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts.
[ "CK1epsilon", "stimulates", "the", "binding", "of", " ", "dsh", "to", " ", "GBP", "in", " ", "Xenopus", "extracts", "." ]
[ "protein", "organism" ]
CK1epsilon is a protein, dsh is a protein, GBP is a protein, Xenopus is an organism
1.0alpha7.train.1396_task1
Sentence: CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts. Instructions: please typing these entity words according to sentence: CK1epsilon, dsh, GBP, Xenopus Options: organism, protein
[ "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "B-organism", "O", "O" ]
CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts.
[ "CK1epsilon", "stimulates", "the", "binding", "of", " ", "dsh", "to", " ", "GBP", "in", " ", "Xenopus", "extracts", "." ]
[ "protein", "organism" ]
CK1epsilon, dsh, GBP, Xenopus
1.0alpha7.train.1396_task2
Sentence: CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts. Instructions: please extract entity words from the input sentence
[ "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "B-organism", "O", "O" ]
CK1epsilon stimulates the binding of dsh to GBP in Xenopus extracts.
[ "CK1epsilon", "stimulates", "the", "binding", "of", " ", "dsh", "to", " ", "GBP", "in", " ", "Xenopus", "extracts", "." ]
[ "protein", "organism" ]
Ultrasound therapy is a Intervention_Physical, recalcitrant diabetic foot ulcers is a Outcome_Physical, non - contact , kilohertz ultrasound therapy is a Intervention_Physical, 55 is a Participant_Sample-size, active 40 KHz ultrasound delivered by a saline mist or a " is a Intervention_Physical, sham device " which delivered a saline mist without the use of ultrasound is a Intervention_Control, proportion of wounds healed is a Outcome_Physical, ultrasound treatment is a Intervention_Physical, adverse events is a Outcome_Adverse-effects, bioburden is a Outcome_Physical, healing rate is a Outcome_Other
24211_task0
Sentence: Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Adverse-effects, Intervention_Physical, Intervention_Control, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O" ]
Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers .
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[ "Intervention_Control", "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Other", "Participant_Sample-size" ]
Ultrasound therapy is a Intervention_Physical, recalcitrant diabetic foot ulcers is a Outcome_Physical, non - contact , kilohertz ultrasound therapy is a Intervention_Physical, 55 is a Participant_Sample-size, active 40 KHz ultrasound delivered by a saline mist or a " is a Intervention_Physical, sham device " which delivered a saline mist without the use of ultrasound is a Intervention_Control, proportion of wounds healed is a Outcome_Physical, ultrasound treatment is a Intervention_Physical, adverse events is a Outcome_Adverse-effects, bioburden is a Outcome_Physical, healing rate is a Outcome_Other
24211_task1
Sentence: Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers . Instructions: please typing these entity words according to sentence: Ultrasound therapy, recalcitrant diabetic foot ulcers, non - contact , kilohertz ultrasound therapy, 55, active 40 KHz ultrasound delivered by a saline mist or a ", sham device " which delivered a saline mist without the use of ultrasound, proportion of wounds healed, ultrasound treatment, adverse events, bioburden, healing rate Options: Outcome_Adverse-effects, Intervention_Physical, Intervention_Control, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O" ]
Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers .
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[ "Intervention_Control", "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Other", "Participant_Sample-size" ]
Ultrasound therapy, recalcitrant diabetic foot ulcers, non - contact , kilohertz ultrasound therapy, 55, active 40 KHz ultrasound delivered by a saline mist or a ", sham device " which delivered a saline mist without the use of ultrasound, proportion of wounds healed, ultrasound treatment, adverse events, bioburden, healing rate
24211_task2
Sentence: Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers . Instructions: please extract entity words from the input sentence
[ "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O" ]
Ultrasound therapy for recalcitrant diabetic foot ulcers : results of a randomized , double-blind , controlled , multicenter study . An estimated 15 % of patients with diabetes will develop a foot ulcer sometime in their life , making them 30 to 40 times more likely to undergo amputation due to a non-healing foot ulcer than the non-diabetic population . To determine the safety and efficacy of a new , non-contact , kilohertz ultrasound therapy for the healing of recalcitrant diabetic foot ulcers - as well as to evaluate the impact on total closure and quantitative bacterial cultures and the effect on healing of various levels of sharp/surgical debridement - a randomized , double-blinded , sham-controlled , multicenter study was conducted in hospital-based and private wound care clinics . Patients ( 55 met criteria for efficacy analysis ) received standard of care , which included products that provide a moist environment , offloading diabetic shoes and socks , debridement , wound evaluation , and measurement . The " therapy " was either active 40 KHz ultrasound delivered by a saline mist or a " sham device " which delivered a saline mist without the use of ultrasound . After 12 weeks of care , the proportion of wounds healed ( defined as complete epithelialization without drainage ) in the active ultrasound therapy device group was significantly higher than that in the sham control group ( 40.7 % versus 14.3 % , P = 0.0366 , Fisher 's exact test ) . The ultrasound treatment was easy to use and no difference in the number and type of adverse events between the two treatment groups was noted . Of interest , wounds were debrided at baseline followed by a quantitative culture biopsy . The results of these cultures demonstrated a significant bioburden ( greater than 10 ( 5 ) ) in the majority of cases , despite a lack of clinical signs of infection . Compared to control , this therapeutic modality was found to increase the healing rate of recalcitrant , diabetic foot ulcers .
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[ "Intervention_Control", "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Other", "Participant_Sample-size" ]
Pemphigoid is an umlsterm, Transplantation is an umlsterm, Mund- is an umlsterm, Nasenschleimhaut is an umlsterm
DerOpthalmologe.70940321.ger.abstr_task0
Sentence: Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern .
[ "Nach", "Symblepharolyse", "bei", "okularem", "Pemphigoid", "wird", "i", ".", "allg", ".", "eine", "Transplantation", "von", "Mund-", "oder", "Nasenschleimhaut", "empfohlen", ",", "um", "Symblepharonrezidive", "zu", "verhindern", "." ]
[ "umlsterm" ]
Pemphigoid is an umlsterm, Transplantation is an umlsterm, Mund- is an umlsterm, Nasenschleimhaut is an umlsterm
DerOpthalmologe.70940321.ger.abstr_task1
Sentence: Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern . Instructions: please typing these entity words according to sentence: Pemphigoid, Transplantation, Mund-, Nasenschleimhaut Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern .
[ "Nach", "Symblepharolyse", "bei", "okularem", "Pemphigoid", "wird", "i", ".", "allg", ".", "eine", "Transplantation", "von", "Mund-", "oder", "Nasenschleimhaut", "empfohlen", ",", "um", "Symblepharonrezidive", "zu", "verhindern", "." ]
[ "umlsterm" ]
Pemphigoid, Transplantation, Mund-, Nasenschleimhaut
DerOpthalmologe.70940321.ger.abstr_task2
Sentence: Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Nach Symblepharolyse bei okularem Pemphigoid wird i . allg. eine Transplantation von Mund- oder Nasenschleimhaut empfohlen , um Symblepharonrezidive zu verhindern .
[ "Nach", "Symblepharolyse", "bei", "okularem", "Pemphigoid", "wird", "i", ".", "allg", ".", "eine", "Transplantation", "von", "Mund-", "oder", "Nasenschleimhaut", "empfohlen", ",", "um", "Symblepharonrezidive", "zu", "verhindern", "." ]
[ "umlsterm" ]
Kleinkinder is an umlsterm, septischer Arthritis is an umlsterm, Hueftgelenks is an umlsterm, Kinder is an umlsterm, hueftgelenknahen is an umlsterm, Osteomyelitis is an umlsterm, Beins is an umlsterm, Protein is an umlsterm, Sonographie is an umlsterm, bildgebende is an umlsterm, Ultraschall is an umlsterm, Schenkelhalsentzuendung is an umlsterm, Therapie is an umlsterm, notfallmaessigen is an umlsterm, Biopsie is an umlsterm, Synovialis is an umlsterm, Antibiotikumtherapie is an umlsterm, gegebenes is an umlsterm, Cefuroxim is an umlsterm, medikamentoese Therapie is an umlsterm, Vene is an umlsterm, Streptokokken is an umlsterm, Staphylococcus aureus is an umlsterm, Staphylococcus epidermidis is an umlsterm, Escherichia coli is an umlsterm, Kultur is an umlsterm, Antibiose is an umlsterm, Kindern is an umlsterm, Therapiebeginn is an umlsterm, Kinder is an umlsterm, Osteomyelitisfolgen is an umlsterm, Gelenks is an umlsterm
DerOrthopaede.70260838.ger.abstr_task0
Sentence: Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern .
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[ "umlsterm" ]
Kleinkinder is an umlsterm, septischer Arthritis is an umlsterm, Hueftgelenks is an umlsterm, Kinder is an umlsterm, hueftgelenknahen is an umlsterm, Osteomyelitis is an umlsterm, Beins is an umlsterm, Protein is an umlsterm, Sonographie is an umlsterm, bildgebende is an umlsterm, Ultraschall is an umlsterm, Schenkelhalsentzuendung is an umlsterm, Therapie is an umlsterm, notfallmaessigen is an umlsterm, Biopsie is an umlsterm, Synovialis is an umlsterm, Antibiotikumtherapie is an umlsterm, gegebenes is an umlsterm, Cefuroxim is an umlsterm, medikamentoese Therapie is an umlsterm, Vene is an umlsterm, Streptokokken is an umlsterm, Staphylococcus aureus is an umlsterm, Staphylococcus epidermidis is an umlsterm, Escherichia coli is an umlsterm, Kultur is an umlsterm, Antibiose is an umlsterm, Kindern is an umlsterm, Therapiebeginn is an umlsterm, Kinder is an umlsterm, Osteomyelitisfolgen is an umlsterm, Gelenks is an umlsterm
DerOrthopaede.70260838.ger.abstr_task1
Sentence: Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern . Instructions: please typing these entity words according to sentence: Kleinkinder, septischer Arthritis, Hueftgelenks, Kinder, hueftgelenknahen, Osteomyelitis, Beins, Protein, Sonographie, bildgebende, Ultraschall, Schenkelhalsentzuendung, Therapie, notfallmaessigen, Biopsie, Synovialis, Antibiotikumtherapie, gegebenes, Cefuroxim, medikamentoese Therapie, Vene, Streptokokken, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Kultur, Antibiose, Kindern, Therapiebeginn, Kinder, Osteomyelitisfolgen, Gelenks Options: umlsterm
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Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern .
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[ "umlsterm" ]
Kleinkinder, septischer Arthritis, Hueftgelenks, Kinder, hueftgelenknahen, Osteomyelitis, Beins, Protein, Sonographie, bildgebende, Ultraschall, Schenkelhalsentzuendung, Therapie, notfallmaessigen, Biopsie, Synovialis, Antibiotikumtherapie, gegebenes, Cefuroxim, medikamentoese Therapie, Vene, Streptokokken, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Kultur, Antibiose, Kindern, Therapiebeginn, Kinder, Osteomyelitisfolgen, Gelenks
DerOrthopaede.70260838.ger.abstr_task2
Sentence: Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern . Instructions: please extract entity words from the input sentence
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Von 1985-1996 ( 12 Jahre ) sahen wir 24 Saeuglinge und Kleinkinder mit septischer Arthritis des Hueftgelenks . Ein kleiner Teil der Kinder war gleichzeitig von einer hueftgelenknahen Osteomyelitis betroffen . Als klinische Befunde sind die schmerzhafte Schonung des Beins bis hin zur Pseudoparalyse , daneben Unwohlsein und Trinkschwaeche von Bedeutung . Im Labor ist das quantitativ bestimmte c-reaktive Protein ( CRP ) und die BSG von Wichtigkeit . Die Sonographie ist das aussagefaehigste bildgebende Verfahren . Im Ultraschall ist fruehzeitig die Kapselverdickung und der septische Erguss , bei laengerem Verlauf die Schenkelhalsentzuendung zu erkennen . Die Therapie besteht in der notfallmaessigen Arthrotomie mit Entnahme des bakteriologischen Abstrichs und der Biopsie aus der Synovialis , evtl. aus dem Schenkelhals . Die Antibiotikumtherapie beginnt unmittelbar nach Abstrichentnahme . Parenteral gegebenes Cefuroxim wird bei anderslautendem Antibiogramm umgesetzt . Die medikamentoese Therapie wird in der Regel 3 Wochen ueber die Vene , danach weitere 3 Wochen oral durchgefuehrt . Der CRP-Verlauf ermoeglicht die Kontrolle der Gesundung . -haemolysierende und vergruenende Streptokokken wurden am haeufigsten im Abstrich nachgewiesen ( 7 mal ) , 2 mal Staphylococcus aureus , 2 mal Staphylococcus epidermidis , 2 mal Escherichia coli ; 8 mal war die Kultur steril , davon war 6 mal eine orale oder parenterale Antibiose vorausgegangen . Bei qualifiziertem fruehzeitigem Behandlungsbeginn ( 18 von 24 Kindern ) bleiben keine erkennbaren Schaeden zurueck . Bei verzoegertem Therapiebeginn ( 7 Kinder ) blieben als Osteomyelitisfolgen begrenzte Schaeden am Schenkelhals bzw. Pfanne zurueck . Die erst nach 5 Wochen durchgefuehrte Arthrotomie und Hueftreposition konnte in einem Fall die Destruktion des Gelenks nicht verhindern .
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[ "umlsterm" ]
Therapie is an umlsterm, Verletzungen is an umlsterm, Kapsel - Band - Strukturen is an umlsterm, Gelenkknorpels is an umlsterm, Therapie is an umlsterm, Zytokine is an umlsterm, Zytokine is an umlsterm, somatischen Gentherapie is an umlsterm, Gentherapie is an umlsterm, gezielten is an umlsterm, Wachstumsfaktoren is an umlsterm, Behandlung is an umlsterm, Verletzungen is an umlsterm
DerOrthopaede.70260450.ger.abstr_task0
Sentence: Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann .
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[ "umlsterm" ]
Therapie is an umlsterm, Verletzungen is an umlsterm, Kapsel - Band - Strukturen is an umlsterm, Gelenkknorpels is an umlsterm, Therapie is an umlsterm, Zytokine is an umlsterm, Zytokine is an umlsterm, somatischen Gentherapie is an umlsterm, Gentherapie is an umlsterm, gezielten is an umlsterm, Wachstumsfaktoren is an umlsterm, Behandlung is an umlsterm, Verletzungen is an umlsterm
DerOrthopaede.70260450.ger.abstr_task1
Sentence: Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann . Instructions: please typing these entity words according to sentence: Therapie, Verletzungen, Kapsel - Band - Strukturen, Gelenkknorpels, Therapie, Zytokine, Zytokine, somatischen Gentherapie, Gentherapie, gezielten, Wachstumsfaktoren, Behandlung, Verletzungen Options: umlsterm
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Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann .
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[ "umlsterm" ]
Therapie, Verletzungen, Kapsel - Band - Strukturen, Gelenkknorpels, Therapie, Zytokine, Zytokine, somatischen Gentherapie, Gentherapie, gezielten, Wachstumsfaktoren, Behandlung, Verletzungen
DerOrthopaede.70260450.ger.abstr_task2
Sentence: Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann . Instructions: please extract entity words from the input sentence
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Eine besondere Herausforderung ist die Therapie von Verletzungen der Kapsel-Band-Strukturen sowie des Gelenkknorpels . Nicht nur die spontane Heilungsfaehigkeit , sondern auch die Reparation nach konservativer oder operativer Therapie ist begrenzt . In den letzten Jahren sind daher Zytokine als Modulatoren der Heilungsvorgaenge in den Blickpunkt des Interesses gerueckt . In diesem Uebersichtsartikel versuchen wir , den zukuenftigen Stellenwert fuer Zytokine einzuschaetzen und Konzepte fuer eine klinische Anwendung zu erarbeiten . Aufgrund bestehender Probleme in der Anwendung von Zytokinen fuehren wir das Konzept der somatischen Gentherapie in diese Ueberlegung ein . Wir postulieren , dass die Gentherapie zur gezielten Applikation von Wachstumsfaktoren die Behandlung zahlreicher Verletzungen veraendern kann .
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[ "umlsterm" ]
Ambulatory activity is a Intervention_Physical, ambulatory activity is a Intervention_Physical
54127_task0
Sentence: Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical
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Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP .
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[ "Intervention_Physical", "Outcome_Physical" ]
Ambulatory activity is a Intervention_Physical, ambulatory activity is a Intervention_Physical
54127_task1
Sentence: Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP . Instructions: please typing these entity words according to sentence: Ambulatory activity, ambulatory activity Options: Intervention_Physical
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Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP .
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[ "Intervention_Physical", "Outcome_Physical" ]
Ambulatory activity, ambulatory activity
54127_task2
Sentence: Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP . Instructions: please extract entity words from the input sentence
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Ambulatory activity of children with cerebral palsy : which characteristics are important ? AIM To assess ambulatory activity of children with cerebral palsy ( CP ) , aged 7 to 13 years , and identify associated characteristics . METHOD Sixty-two children with spastic CP ( 39 males , 23 females ; mean age 10y 1mo , SD 1y 8mo ; age range 7-13y ) , classified as Gross Motor Function Classification System ( GMFCS ) levels I to III , participated . Ambulatory activity was measured during 1 week with a StepWatch activity monitor as steps per day , and time spent at medium and high step rates . Multiple linear regression analyses were performed following a backward selection procedure until only independent variables with p < 0.05 remained in the model . Ambulatory activity outcome parameters served as dependent variables , and disease , personal , and environmental characteristics as independent variables . Ambulatory activity was corrected for body height . RESULTS Children took more steps during school days ( 5169 steps , SD 1641 ) than during weekend days ( 4158 steps , SD 2048 ; p < 0.001 ) . Higher GMFCS level , bilateral CP , and higher age were associated with lower ambulatory activity on school days ( R ( 2 ) ranged from 43-53 % ) , whereas bilateral CP , higher age , and no sport club participation were associated with lower ambulatory activity in the weekend ( R ( 2 ) ranged from 21-42 % ) . Correcting for body height decreased the association with age . INTERPRETATION Interventions should focus at increasing physical activity at the weekend for children with bilateral spastic CP .
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[ "Intervention_Physical", "Outcome_Physical" ]
CpG is a compound, interleukin-6 is a protein, IL-6 is a protein
DS.d67_task0
Sentence: A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
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A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C.
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[ "protein", "compound" ]
CpG is a compound, interleukin-6 is a protein, IL-6 is a protein
DS.d67_task1
Sentence: A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C. Instructions: please typing these entity words according to sentence: CpG, interleukin-6, IL-6 Options: compound, protein
[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C.
[ "A", "novel", "oligodeoxynuleotides", "containing", "11", "CpG", "motifs", "was", "synthesized", "and", "inserted", "into", "the", "VR1020", "plasmid", "containing", "pig", "interleukin-6", "(", "IL-6", ")", "gene", "(", "VPIL6", ")", "to", "construct", "recombinant", "plasmid", ",", "VPIL6C." ]
[ "protein", "compound" ]
CpG, interleukin-6, IL-6
DS.d67_task2
Sentence: A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C.
[ "A", "novel", "oligodeoxynuleotides", "containing", "11", "CpG", "motifs", "was", "synthesized", "and", "inserted", "into", "the", "VR1020", "plasmid", "containing", "pig", "interleukin-6", "(", "IL-6", ")", "gene", "(", "VPIL6", ")", "to", "construct", "recombinant", "plasmid", ",", "VPIL6C." ]
[ "protein", "compound" ]
pathologic precursors of lung cancer is a Disease, cancer is a Disease, basal cell hyperplasia is a Disease, mucous cell metaplasia is a Disease, lung cancer is a Disease, lung cancer is a Disease, tobacco is a Plant, lung cancer is a Disease
8983097_task0
Sentence: We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant
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We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk.
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[ "Disease", "Plant" ]
pathologic precursors of lung cancer is a Disease, cancer is a Disease, basal cell hyperplasia is a Disease, mucous cell metaplasia is a Disease, lung cancer is a Disease, lung cancer is a Disease, tobacco is a Plant, lung cancer is a Disease
8983097_task1
Sentence: We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk. Instructions: please typing these entity words according to sentence: pathologic precursors of lung cancer, cancer, basal cell hyperplasia, mucous cell metaplasia, lung cancer, lung cancer, tobacco, lung cancer Options: Disease, Plant
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We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk.
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[ "Disease", "Plant" ]
pathologic precursors of lung cancer, cancer, basal cell hyperplasia, mucous cell metaplasia, lung cancer, lung cancer, tobacco, lung cancer
8983097_task2
Sentence: We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk. Instructions: please extract entity words from the input sentence
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We have undertaken an autopsy-based study to evaluate the etiologic importance of active and passive smoking, as well as socio-demographic variables, in the development of pathologic precursors of lung cancer. Lung specimens were taken at autopsy from 531 persons who had died within four hours from a cause other than respiratory or cancer in Athens (Greece) or the surrounding area. Specimens were examined blindly for basal cell hyperplasia, squamous cell metaplasia, cell atypia and mucous cell metaplasia, i.e., pathological entities considered as epithelial, possibly precancerous, lesions (EPPL). Interviews were conducted with next of kin of the deceased. Suitable autopsy specimens as well as completed interviews were eventually available for 275 subjects. EPPL score was regressed on the available independent variables. EPPL score was higher among active smokers than among nonsmokers, while ex-smokers occupied an intermediate position. Conditional on smoking habits, EPPL score was higher among women than among men and higher among manual than among non-manual workers, in agreement with the corresponding patterns with respect to lung cancer. Nonsmoking women married to ever smokers had significantly higher EPPL score than those married to never smokers. The overall findings of this study suggest that EPPL is a valuable indicator of lung cancer risk and that exposure to environmental tobacco smoke is associated with higher EPPL levels and therefore with higher lung cancer risk.
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[ "Disease", "Plant" ]
cardiac toxicity is a ADVERSE, B - cell non - Hodgkin 's lymphoma is a DISEASE, non - Hodgkin 's lymphoma is a DISEASE, cardiotoxicity is a ADVERSE, diffuse large B - cell lymphoma is a DISEASE, DLBCL is a DISEASE, DLBCL is a DISEASE, congestive heart failure is a ADVERSE, CHF is a ADVERSE, CHF is a ADVERSE, DLBCL is a DISEASE, CHF is a ADVERSE, CHF is a ADVERSE, prior heart disease is a ADVERSE, diabetes is a ADVERSE, hypertension is a ADVERSE, hypertension is a ADVERSE, CHF is a ADVERSE, DLBCL is a DISEASE, prior heart disease is a ADVERSE, CHF is a ADVERSE, CHF is a ADVERSE, hypertension is a ADVERSE, DLBCL is a DISEASE, CHF is a ADVERSE
example-292_task0
Sentence: Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ADVERSE, DISEASE
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Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk.
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[ "DISEASE", "ADVERSE" ]
cardiac toxicity is a ADVERSE, B - cell non - Hodgkin 's lymphoma is a DISEASE, non - Hodgkin 's lymphoma is a DISEASE, cardiotoxicity is a ADVERSE, diffuse large B - cell lymphoma is a DISEASE, DLBCL is a DISEASE, DLBCL is a DISEASE, congestive heart failure is a ADVERSE, CHF is a ADVERSE, CHF is a ADVERSE, DLBCL is a DISEASE, CHF is a ADVERSE, CHF is a ADVERSE, prior heart disease is a ADVERSE, diabetes is a ADVERSE, hypertension is a ADVERSE, hypertension is a ADVERSE, CHF is a ADVERSE, DLBCL is a DISEASE, prior heart disease is a ADVERSE, CHF is a ADVERSE, CHF is a ADVERSE, hypertension is a ADVERSE, DLBCL is a DISEASE, CHF is a ADVERSE
example-292_task1
Sentence: Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk. Instructions: please typing these entity words according to sentence: cardiac toxicity, B - cell non - Hodgkin 's lymphoma, non - Hodgkin 's lymphoma, cardiotoxicity, diffuse large B - cell lymphoma, DLBCL, DLBCL, congestive heart failure, CHF, CHF, DLBCL, CHF, CHF, prior heart disease, diabetes, hypertension, hypertension, CHF, DLBCL, prior heart disease, CHF, CHF, hypertension, DLBCL, CHF Options: ADVERSE, DISEASE
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Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk.
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[ "DISEASE", "ADVERSE" ]
cardiac toxicity, B - cell non - Hodgkin 's lymphoma, non - Hodgkin 's lymphoma, cardiotoxicity, diffuse large B - cell lymphoma, DLBCL, DLBCL, congestive heart failure, CHF, CHF, DLBCL, CHF, CHF, prior heart disease, diabetes, hypertension, hypertension, CHF, DLBCL, prior heart disease, CHF, CHF, hypertension, DLBCL, CHF
example-292_task2
Sentence: Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk. Instructions: please extract entity words from the input sentence
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Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. PURPOSE: Anthracycline-based chemotherapy, which improves survival for patients with non-Hodgkin's lymphoma, is often withheld from elderly patients because of its cardiotoxicity. We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: Among patients age > or = 65 years diagnosed with DLBCL from 1991 to 2002 in the Surveillance, Epidemiology, and End Results-Medicare database, we developed logistic regression models of the associations of doxorubicin with demographic, clinical, and cardiac variables. We then developed Cox proportional hazards models of the association between doxorubicin and subsequent congestive heart failure (CHF), taking predictors of CHF into account. RESULTS: Of 9,438 patients with DLBCL, 3,164 (42%) received doxorubicin-based chemotherapy. Any doxorubicin use was associated with a 29% increase in risk of CHF (95% CI, 1.02 to 1.62); CHF risk increased with number of doxorubicin claims, increasing age, prior heart disease, comorbidities, diabetes, and hypertension; hypertension intensified the effect of doxorubicin on risk of CHF (hazard ratio = 1.8; P < .01). In the 8 years after diagnosis, the adjusted CHF-free survival rate was 74% in doxorubicin-treated patients versus 79% in patients not treated with doxorubicin. CONCLUSION: Among patients receiving chemotherapy for DLBCL, those with prior heart disease were less likely than others to be treated with doxorubicin, and those who received doxorubicin were more likely than others to develop CHF. Various cardiac risk factors increased CHF risk, but only hypertension was synergistic with doxorubicin. Doxorubicin has dramatically improved survival of DLBCL patients; nonetheless, some subgroups may benefit from efforts to reduce doxorubicin-related CHF risk.
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[ "DISEASE", "ADVERSE" ]
CAT is a Protein, granulocyte / macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein
2193097_task0
Sentence: Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection.
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[ "Protein" ]
CAT is a Protein, granulocyte / macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein
2193097_task1
Sentence: Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection. Instructions: please typing these entity words according to sentence: CAT, granulocyte / macrophage colony - stimulating factor, GM - CSF Options: Protein
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Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection.
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[ "Protein" ]
CAT, granulocyte / macrophage colony - stimulating factor, GM - CSF
2193097_task2
Sentence: Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection. Instructions: please extract entity words from the input sentence
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Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line. This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B). Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells. LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line. The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection.
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[ "Protein" ]
Patienten is an umlsterm, rheumatoider Arthritis is an umlsterm, zementfrei is an umlsterm, zementfreien is an umlsterm, zementfrei is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, Prothesen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, zementfreien is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, radiologisch is an umlsterm, Hueftgelenken is an umlsterm, Hueftgelenks is an umlsterm, Pfannenbodens is an umlsterm, zementfreien is an umlsterm, Osseointegration is an umlsterm, Beurteilung is an umlsterm, Knochenumbaus is an umlsterm, Knochenumbau is an umlsterm
DerOrthopaede.80270354.ger.abstr_task0
Sentence: Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta .
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[ "umlsterm" ]
Patienten is an umlsterm, rheumatoider Arthritis is an umlsterm, zementfrei is an umlsterm, zementfreien is an umlsterm, zementfrei is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, Prothesen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, zementfreien is an umlsterm, Patienten is an umlsterm, zementfreien is an umlsterm, radiologisch is an umlsterm, Hueftgelenken is an umlsterm, Hueftgelenks is an umlsterm, Pfannenbodens is an umlsterm, zementfreien is an umlsterm, Osseointegration is an umlsterm, Beurteilung is an umlsterm, Knochenumbaus is an umlsterm, Knochenumbau is an umlsterm
DerOrthopaede.80270354.ger.abstr_task1
Sentence: Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta . Instructions: please typing these entity words according to sentence: Patienten, rheumatoider Arthritis, zementfrei, zementfreien, zementfrei, Patienten, zementfreien, Prothesen, Patienten, Patienten, radiologischen, Patienten, zementfreien, zementfreien, Patienten, zementfreien, radiologisch, Hueftgelenken, Hueftgelenks, Pfannenbodens, zementfreien, Osseointegration, Beurteilung, Knochenumbaus, Knochenumbau Options: umlsterm
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Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta .
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[ "umlsterm" ]
Patienten, rheumatoider Arthritis, zementfrei, zementfreien, zementfrei, Patienten, zementfreien, Prothesen, Patienten, Patienten, radiologischen, Patienten, zementfreien, zementfreien, Patienten, zementfreien, radiologisch, Hueftgelenken, Hueftgelenks, Pfannenbodens, zementfreien, Osseointegration, Beurteilung, Knochenumbaus, Knochenumbau
DerOrthopaede.80270354.ger.abstr_task2
Sentence: Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta . Instructions: please extract entity words from the input sentence
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Von 1986-1996 wurden bei 65 Patienten mit rheumatoider Arthritis ( RA ) 92 Hueftendoprothesen ( 86 zementfrei , 4 hybrid , 2 zementiert ) implantiert . Von den 89 zementfreien Pfannen waren 59 Schraubpfannen ( Hofer-Imhof : n = 45 ; Zweymueller : n = 7 ; Mecring : n = 5 ; PM : n = 2 ) und 30 sphaerische Pfannen vom Typ Harris-Galante ; 87 Schaefte wurden zementfrei ( Zweymueller-SL : n = 58 ; Uni : n = 16 ; Schenker : n = 9 ; Zweymueller I : n = 4 ) und 5 zementiert eingesetzt . Postoperativ starb eine Patientin , 3 Patienten ( 4 Implantate ) innerhalb des 1. postoperativen Jahres . Von jedem Schraubpfannentyp musste bisher eine Pfanne gewechselt werden ( 4 von 59 ; ca. 6,8 % ) . Bei 3 von 87 Schaeften ( ca. 3,4 % ; einmal Zweymueller I , einmal Schenker , einmal Zweymueller SL ) war ebenfalls ein Wechsel erforderlich , so dass bei insgesamt 7 von 86 ( ca. 8 % ) zementfreien Prothesen ein Wechsel erfolgte . 10 Patienten mit 12 Hueftendoprothesen sind zur Nachuntersuchung z . T. wegen ihres reduzierten Allgemeinzustands nicht erschienen ; 4 Patienten ( 5 Implantate ) sind verstorben . Die klinischen und radiologischen Ergebnisse der Hueftendoprothesen von 52 Patienten mit 70 zementfreien Pfannen und 68 zementfreien bzw. 2 zementierten Schaeften zeigen nach durchschnittlich 4,5 ( 1-11 Jahren ) einen Harris-Hip-Score von durchschnittlich 72 ( 25-96 ) ; 10 Patienten haben geringe Beschwerden im Hueftbereich ; ca. 79 % der zementfreien Implantate ( 70 von 89 Pfannen , 69 von 87 Schaeften ) wurden radiologisch ausgewertet ; 2 Schraubpfannen zeigen eine geringe Positionsaenderung nach Spongiosaplastik bei Pfannenprotrusion , die insgesamt bei 13 Hueftgelenken praeoperativ vorlag . Diese bildete sich nach Auffuellung mit autologen Spongiosachips und Rezentrierung des Hueftgelenks deutlich zurueck . Es kam zu einem Neuaufbau des Pfannenbodens mit homogenen Durchbau der Spongiosaplastik , wobei diese eine deutliche Verschmaelerung zeigte . Die zementfreien Pfannen haben in ca. 75 % einen Typ I mit vollstaendiger Osseointegration , in ca. 19 % einen Typ II mit Saum an einzelnen Gewindegaengen , in einer Zone oder maximal 50 % der Bedeckungsflaeche und in ca. 6 % einen Typ III mit Saum in mehr als 50 % der knoechernen Bedeckungsflaeche . Die Beurteilung hinsichtlich des Knochenumbaus am Schaft ergab fuer den am haeufigsten verwendeten Schaft ( Zweymueller SL ) in ca. 47 % einen Typ I mit nur geringem Knochenumbau am Calcar , in ca. 33 % einen Typ II mit deutlicher Spongiosierung im gesamten Schaftbereich , jedoch bei erhaltener Kompaktabreite , und in ca. 20 % einen Typ III mit deutlicher Spongiosierung und Verschmaelerung der Kompakta .
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[ "umlsterm" ]
septic is a Participant_Condition, hemoperfusion is a Intervention_Pharmacological, neutral microporous resin hemoperfusion is a Intervention_Pharmacological, severe sepsis . is a Participant_Condition, Forty - four is a Participant_Sample-size, severe sepsis or septic shock is a Participant_Condition, HA type hemoperfusion treatment is a Intervention_Pharmacological, HA330 hemoperfusion is a Intervention_Pharmacological, plasma concentrations of IL-6 is a Outcome_Physical, IL-8 is a Outcome_Physical, hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure is a Outcome_Physical, change of hematology and coagulation function is a Outcome_Physical, organ function is a Outcome_Physical, sequential organ failure assessment ( SOFA ) score is a Outcome_Physical, Hospital , 28-day , and ICU mortality is a Outcome_Mortality, HA hemoperfusion is a Intervention_Pharmacological, plasma IL-6 is a Outcome_Physical, significant increases is a Outcome_Other, cardiac index , systemic vascular resistant index is a Outcome_Physical, fast withdrawal of vasoactive agents and decreases in heart rate is a Outcome_Physical, significant difference is a Outcome_Other, organ dysfunction is a Outcome_Physical, SOFA scores is a Outcome_Physical, 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay is a Outcome_Mortality, reduced . is a Outcome_Other, organ dysfunction , ICU mortality , and shorten the length of ICU stay . is a Outcome_Other
48450_task0
Sentence: Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU .
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[ "Outcome_Mortality", "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size" ]
septic is a Participant_Condition, hemoperfusion is a Intervention_Pharmacological, neutral microporous resin hemoperfusion is a Intervention_Pharmacological, severe sepsis . is a Participant_Condition, Forty - four is a Participant_Sample-size, severe sepsis or septic shock is a Participant_Condition, HA type hemoperfusion treatment is a Intervention_Pharmacological, HA330 hemoperfusion is a Intervention_Pharmacological, plasma concentrations of IL-6 is a Outcome_Physical, IL-8 is a Outcome_Physical, hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure is a Outcome_Physical, change of hematology and coagulation function is a Outcome_Physical, organ function is a Outcome_Physical, sequential organ failure assessment ( SOFA ) score is a Outcome_Physical, Hospital , 28-day , and ICU mortality is a Outcome_Mortality, HA hemoperfusion is a Intervention_Pharmacological, plasma IL-6 is a Outcome_Physical, significant increases is a Outcome_Other, cardiac index , systemic vascular resistant index is a Outcome_Physical, fast withdrawal of vasoactive agents and decreases in heart rate is a Outcome_Physical, significant difference is a Outcome_Other, organ dysfunction is a Outcome_Physical, SOFA scores is a Outcome_Physical, 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay is a Outcome_Mortality, reduced . is a Outcome_Other, organ dysfunction , ICU mortality , and shorten the length of ICU stay . is a Outcome_Other
48450_task1
Sentence: Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU . Instructions: please typing these entity words according to sentence: septic, hemoperfusion, neutral microporous resin hemoperfusion, severe sepsis ., Forty - four, severe sepsis or septic shock, HA type hemoperfusion treatment, HA330 hemoperfusion, plasma concentrations of IL-6, IL-8, hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure, change of hematology and coagulation function, organ function, sequential organ failure assessment ( SOFA ) score, Hospital , 28-day , and ICU mortality, HA hemoperfusion, plasma IL-6, significant increases, cardiac index , systemic vascular resistant index, fast withdrawal of vasoactive agents and decreases in heart rate, significant difference, organ dysfunction, SOFA scores, 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay, reduced ., organ dysfunction , ICU mortality , and shorten the length of ICU stay . Options: Intervention_Pharmacological, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU .
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[ "Outcome_Mortality", "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size" ]
septic, hemoperfusion, neutral microporous resin hemoperfusion, severe sepsis ., Forty - four, severe sepsis or septic shock, HA type hemoperfusion treatment, HA330 hemoperfusion, plasma concentrations of IL-6, IL-8, hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure, change of hematology and coagulation function, organ function, sequential organ failure assessment ( SOFA ) score, Hospital , 28-day , and ICU mortality, HA hemoperfusion, plasma IL-6, significant increases, cardiac index , systemic vascular resistant index, fast withdrawal of vasoactive agents and decreases in heart rate, significant difference, organ dysfunction, SOFA scores, 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay, reduced ., organ dysfunction , ICU mortality , and shorten the length of ICU stay .
48450_task2
Sentence: Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU . Instructions: please extract entity words from the input sentence
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Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column . The aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement , removal of inflammatory cytokines , and mortality in critical care patients with severe sepsis . Forty-four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment ( N=24 ) or standard therapy ( N=20 ) . Those undergoing hemoperfusion treatment received HA330 hemoperfusion . We measured the plasma concentrations of IL-6 and IL-8 at the start of every hemoperfusion treatment , and the following parameters were compared between the control group and the hemoperfusion group on days 3 , 7 , and 14 : hemodynamics ( cardiac index , systemic vascular resistance index , heart rate , and mean arterial pressure ) ; change of hematology and coagulation function ; organ function ; and the sequential organ failure assessment ( SOFA ) score . Hospital , 28-day , and ICU mortality were also observed . Patients treated with HA hemoperfusion showed a significant removal of plasma IL-6 and IL-8 over time while in the study . Patients in the HA group also demonstrated significant increases in cardiac index , systemic vascular resistant index , fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7 . Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 ( baseline ) to day 7 , significant improvement can be demonstrated in the hemoperfusion group at day 14 . There was no significant difference between the groups in 28-day mortality , hospital mortality , or length of hospital stay , but ICU mortality and the length of ICU stay in the HA group were markedly reduced . Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction , ICU mortality , and shorten the length of ICU stay . Clinical significant removal of inflammatory cytokines such as IL-6 and IL-8 from circulation by hemoperfusion may contribute to improving a patient 's outcome in an ICU .
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[ "Outcome_Mortality", "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size" ]
Staphylococcus aureus is an umlsterm, Haemophilus influenzae is an umlsterm, Kingella kingae is an umlsterm, septischen Arthritis is an umlsterm, Kulturbedingungen is an umlsterm, Fluessigmediumblutkultursystemen is an umlsterm, Respirationstrakt is an umlsterm, Osteomyelitis is an umlsterm, septische Arthritis is an umlsterm, Meningitis is an umlsterm
MonatsschriftKinderheilkunde.81460938.ger.abstr_task0
Sentence: Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben .
[ "Neben", "Staphylococcus", "aureus", "und", "Haemophilus", "influenzae", "ist", "in", "seltenen", "Faellen", "Kingella", "kingae", "als", "Erreger", "einer", "septischen", "Arthritis", "isoliert", "worden", ".", "K.", "kingae", "ist", "ein", "gramnegatives", ",", "kokkoides", "Staebchen", ",", "welches", "langsam", "waechst", "und", "hohe", "Ansprueche", "an", "die", "Kulturbedingungen", "stellt", ".", "Der", "bakterielle", "Nachweis", "gelingt", "nur", "schwer", ",", "wird", "aber", "durch", "die", "Anzucht", "in", "aeroben", "Fluessigmediumblutkultursystemen", "und", "eine", "laengere", "Bebruetungszeit", "verbessert", ".", "K.", "kingae", "besiedelt", "in", "der", "Regel", "den", "Respirationstrakt", ".", "Invasive", "Erkrankungen", ",", "wie", "Osteomyelitis", ",", "septische", "Arthritis", "und", "Meningitis", ",", "wurden", "im", "Kindesalter", "beschrieben", "." ]
[ "umlsterm" ]
Staphylococcus aureus is an umlsterm, Haemophilus influenzae is an umlsterm, Kingella kingae is an umlsterm, septischen Arthritis is an umlsterm, Kulturbedingungen is an umlsterm, Fluessigmediumblutkultursystemen is an umlsterm, Respirationstrakt is an umlsterm, Osteomyelitis is an umlsterm, septische Arthritis is an umlsterm, Meningitis is an umlsterm
MonatsschriftKinderheilkunde.81460938.ger.abstr_task1
Sentence: Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben . Instructions: please typing these entity words according to sentence: Staphylococcus aureus, Haemophilus influenzae, Kingella kingae, septischen Arthritis, Kulturbedingungen, Fluessigmediumblutkultursystemen, Respirationstrakt, Osteomyelitis, septische Arthritis, Meningitis Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben .
[ "Neben", "Staphylococcus", "aureus", "und", "Haemophilus", "influenzae", "ist", "in", "seltenen", "Faellen", "Kingella", "kingae", "als", "Erreger", "einer", "septischen", "Arthritis", "isoliert", "worden", ".", "K.", "kingae", "ist", "ein", "gramnegatives", ",", "kokkoides", "Staebchen", ",", "welches", "langsam", "waechst", "und", "hohe", "Ansprueche", "an", "die", "Kulturbedingungen", "stellt", ".", "Der", "bakterielle", "Nachweis", "gelingt", "nur", "schwer", ",", "wird", "aber", "durch", "die", "Anzucht", "in", "aeroben", "Fluessigmediumblutkultursystemen", "und", "eine", "laengere", "Bebruetungszeit", "verbessert", ".", "K.", "kingae", "besiedelt", "in", "der", "Regel", "den", "Respirationstrakt", ".", "Invasive", "Erkrankungen", ",", "wie", "Osteomyelitis", ",", "septische", "Arthritis", "und", "Meningitis", ",", "wurden", "im", "Kindesalter", "beschrieben", "." ]
[ "umlsterm" ]
Staphylococcus aureus, Haemophilus influenzae, Kingella kingae, septischen Arthritis, Kulturbedingungen, Fluessigmediumblutkultursystemen, Respirationstrakt, Osteomyelitis, septische Arthritis, Meningitis
MonatsschriftKinderheilkunde.81460938.ger.abstr_task2
Sentence: Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Neben Staphylococcus aureus und Haemophilus influenzae ist in seltenen Faellen Kingella kingae als Erreger einer septischen Arthritis isoliert worden . K. kingae ist ein gramnegatives , kokkoides Staebchen , welches langsam waechst und hohe Ansprueche an die Kulturbedingungen stellt . Der bakterielle Nachweis gelingt nur schwer , wird aber durch die Anzucht in aeroben Fluessigmediumblutkultursystemen und eine laengere Bebruetungszeit verbessert . K. kingae besiedelt in der Regel den Respirationstrakt . Invasive Erkrankungen , wie Osteomyelitis , septische Arthritis und Meningitis , wurden im Kindesalter beschrieben .
[ "Neben", "Staphylococcus", "aureus", "und", "Haemophilus", "influenzae", "ist", "in", "seltenen", "Faellen", "Kingella", "kingae", "als", "Erreger", "einer", "septischen", "Arthritis", "isoliert", "worden", ".", "K.", "kingae", "ist", "ein", "gramnegatives", ",", "kokkoides", "Staebchen", ",", "welches", "langsam", "waechst", "und", "hohe", "Ansprueche", "an", "die", "Kulturbedingungen", "stellt", ".", "Der", "bakterielle", "Nachweis", "gelingt", "nur", "schwer", ",", "wird", "aber", "durch", "die", "Anzucht", "in", "aeroben", "Fluessigmediumblutkultursystemen", "und", "eine", "laengere", "Bebruetungszeit", "verbessert", ".", "K.", "kingae", "besiedelt", "in", "der", "Regel", "den", "Respirationstrakt", ".", "Invasive", "Erkrankungen", ",", "wie", "Osteomyelitis", ",", "septische", "Arthritis", "und", "Meningitis", ",", "wurden", "im", "Kindesalter", "beschrieben", "." ]
[ "umlsterm" ]
adrenoceptor is a GENE-N
2886573_task0
Sentence: Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man.
[ "Differential", "haemodynamic", "effects", "induced", "by", "beta", "1-(bisoprolol", ")", "or", "beta", "2-(ICI", "118,551", ")", "adrenoceptor", "blockade", "in", "man", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
adrenoceptor is a GENE-N
2886573_task1
Sentence: Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man. Instructions: please typing these entity words according to sentence: adrenoceptor Options: GENE-N
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man.
[ "Differential", "haemodynamic", "effects", "induced", "by", "beta", "1-(bisoprolol", ")", "or", "beta", "2-(ICI", "118,551", ")", "adrenoceptor", "blockade", "in", "man", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
adrenoceptor
2886573_task2
Sentence: Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
Differential haemodynamic effects induced by beta 1-(bisoprolol) or beta 2-(ICI 118,551) adrenoceptor blockade in man.
[ "Differential", "haemodynamic", "effects", "induced", "by", "beta", "1-(bisoprolol", ")", "or", "beta", "2-(ICI", "118,551", ")", "adrenoceptor", "blockade", "in", "man", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
back pain is an umlsterm, industrialized countries is an umlsterm, Disorders is an umlsterm, cause is an umlsterm, direct is an umlsterm, health care costs is an umlsterm, prevalence is an umlsterm, health care is an umlsterm, evaluations is an umlsterm, review is an umlsterm, epidemiologic studies is an umlsterm, population is an umlsterm, back pain is an umlsterm, prevalence is an umlsterm, pain is an umlsterm, adult is an umlsterm, population is an umlsterm, back pain is an umlsterm, adult is an umlsterm, population is an umlsterm, industrialized countries is an umlsterm, back pain is an umlsterm, forms is an umlsterm, women is an umlsterm, Back pain is an umlsterm, prevalence is an umlsterm, Older is an umlsterm, persons is an umlsterm, prevalence is an umlsterm, prevalence is an umlsterm, men is an umlsterm, women is an umlsterm, prevalence is an umlsterm, Back pain is an umlsterm, pain is an umlsterm, pain is an umlsterm, history is an umlsterm, industrialized countries is an umlsterm, back pain is an umlsterm, symptoms is an umlsterm, direct is an umlsterm, health care costs is an umlsterm, patients is an umlsterm, disabled is an umlsterm, back pain is an umlsterm, history is an umlsterm, back pain is an umlsterm, job satisfaction is an umlsterm, role is an umlsterm, back pain is an umlsterm, prognosis is an umlsterm, pain is an umlsterm, prognosis is an umlsterm, absenteeism is an umlsterm, back pain is an umlsterm, back pain is an umlsterm, single is an umlsterm, symptom is an umlsterm, back pain is an umlsterm, pain is an umlsterm, joint is an umlsterm, back pain is an umlsterm, pain syndrome is an umlsterm
ManuelleMedizin.80360048.eng.abstr_task0
Sentence: In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome .
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[ "umlsterm" ]
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ManuelleMedizin.80360048.eng.abstr_task1
Sentence: In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome . Instructions: please typing these entity words according to sentence: back pain, industrialized countries, Disorders, cause, direct, health care costs, prevalence, health care, evaluations, review, epidemiologic studies, population, back pain, prevalence, pain, adult, population, back pain, adult, population, industrialized countries, back pain, forms, women, Back pain, prevalence, Older, persons, prevalence, prevalence, men, women, prevalence, Back pain, pain, pain, history, industrialized countries, back pain, symptoms, direct, health care costs, patients, disabled, back pain, history, back pain, job satisfaction, role, back pain, prognosis, pain, prognosis, absenteeism, back pain, back pain, single, symptom, back pain, pain, joint, back pain, pain syndrome Options: umlsterm
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In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome .
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[ "umlsterm" ]
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ManuelleMedizin.80360048.eng.abstr_task2
Sentence: In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome . Instructions: please extract entity words from the input sentence
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In the last decades back pain has reached dramatic proportions in industrialized countries . Disorders of the back are nowadays the leading cause of direct and indirect health care costs . Accurate prevalence estimates are needed to serve as a basis for health care evaluations . A review of epidemiologic studies in the general population reveals that back pain has reached a prevalence of 40 % for current pain . 7 to 18 % are " frequently " , " often " , " daily " or " constantly " affected . 75 % of the adult population suffers from back pain during the last year . 80 to 90 % of the adult population in industrialized countries experience back pain ever . Gender specific differences are only present in severe , chronic forms which are more often experienced by women . Back pain has a prevalence maximum at 50 to 64 years . Older persons display lower prevalence estimates . The prevalence maximum in men is one decade earlier than in women . There are several potential explanations for this prevalence pattern that are discussed in the article . Back pain can be classified by location , temporal characteristics , pain intensity and pain history . Currently , for none of these dimensions generally accepted , uniformly employed and validated definitions are available . In most of the industrialized countries back pain is one of the most expensive symptoms . 75-90 % of the direct and indirect health care costs were caused by those 5-10 % of patients who are disabled . As predictors of back pain a history of back pain and job satisfaction play by far a more important role than the extensively studied mechanical factors . For a first episode of back pain the prognosis is favorable . If the pain persist for more than three months the prognosis is unfavorable . After six months of absenteeism because of back pain more than half of the afflicted never return to work . Rarely back pain is present as a single symptom . In more than 80 % back pain is associated with pain in at least one joint . It remains to be studied if back pain may be viewed as an entity or as part of a more complex pain syndrome .
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[ "umlsterm" ]
hydrogen sulfide is a CHEMICAL
15671155_task0
Sentence: Role of hydrogen sulfide in acute pancreatitis and associated lung injury. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL
[ "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Role of hydrogen sulfide in acute pancreatitis and associated lung injury.
[ "Role", "of", "hydrogen", "sulfide", "in", "acute", "pancreatitis", "and", "associated", "lung", "injury", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
hydrogen sulfide is a CHEMICAL
15671155_task1
Sentence: Role of hydrogen sulfide in acute pancreatitis and associated lung injury. Instructions: please typing these entity words according to sentence: hydrogen sulfide Options: CHEMICAL
[ "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Role of hydrogen sulfide in acute pancreatitis and associated lung injury.
[ "Role", "of", "hydrogen", "sulfide", "in", "acute", "pancreatitis", "and", "associated", "lung", "injury", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
hydrogen sulfide
15671155_task2
Sentence: Role of hydrogen sulfide in acute pancreatitis and associated lung injury. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Role of hydrogen sulfide in acute pancreatitis and associated lung injury.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]