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Fallberichten, Therapie, Harnleiterobstruktion, Harnleiterschiene, Harnleiters, Nierenbeckenkelchsystems, Technik, Urinfluss, Urinpassage, Harnleiterschienen, Harnleiterkompression, Schiene, Therapiealternative, Patienten
DerUrologeA.90380150.ger.abstr_task2
Sentence: Anhand von 5 Fallberichten wird ueber die Therapie der extrinsischen Harnleiterobstruktion durch die Einlage von 2 ipsilateralen inneren Doppel-J-Harnleiterschienen berichtet , nachdem die Einlage einer singulaeren inneren Harnleiterschiene trotz korrekter Lage zu keiner suffizienten Entstauung des Harnleiters und Nierenbeckenkelchsystems gefuehrt hatte . Durch die erhoehte Festigkeit von 2 parallelen inneren Schienen konnten Obstruktion und Kinking vermindert und eine Rueckbildung der Stauung des proximalen Hohlsystems erzielt werden . Ferner ermoeglicht diese Technik neben dem Urinfluss innerhalb der Schienen einen vermehrten Fluss zwischen den Schienen , der als entscheidender Mechanismus der Urinpassage bei liegenden Harnleiterschienen angesehen wird . In Faellen extrinsischer Harnleiterkompression , in denen durch die Einlage einer singulaeren inneren Schiene keine suffiziente Rueckbildung der Ektasie des vorgeschalteten intra- und extrarenalen Hohlraumsystems erreicht werden kann , sollte die simultane Einlage von 2 ipsilateralen inneren Doppel-J-Harnleiterschienen als technisch einfache , komplikationsarme Therapiealternative in Betracht gezogen werden , die einigen Patienten die Einlage eines perkutanen Nephrostomiekatheters oder invasivere Massnahmen ersparen kann . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Anhand von 5 Fallberichten wird ueber die Therapie der extrinsischen Harnleiterobstruktion durch die Einlage von 2 ipsilateralen inneren Doppel-J-Harnleiterschienen berichtet , nachdem die Einlage einer singulaeren inneren Harnleiterschiene trotz korrekter Lage zu keiner suffizienten Entstauung des Harnleiters und Nierenbeckenkelchsystems gefuehrt hatte . Durch die erhoehte Festigkeit von 2 parallelen inneren Schienen konnten Obstruktion und Kinking vermindert und eine Rueckbildung der Stauung des proximalen Hohlsystems erzielt werden . Ferner ermoeglicht diese Technik neben dem Urinfluss innerhalb der Schienen einen vermehrten Fluss zwischen den Schienen , der als entscheidender Mechanismus der Urinpassage bei liegenden Harnleiterschienen angesehen wird . In Faellen extrinsischer Harnleiterkompression , in denen durch die Einlage einer singulaeren inneren Schiene keine suffiziente Rueckbildung der Ektasie des vorgeschalteten intra- und extrarenalen Hohlraumsystems erreicht werden kann , sollte die simultane Einlage von 2 ipsilateralen inneren Doppel-J-Harnleiterschienen als technisch einfache , komplikationsarme Therapiealternative in Betracht gezogen werden , die einigen Patienten die Einlage eines perkutanen Nephrostomiekatheters oder invasivere Massnahmen ersparen kann .
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[ "umlsterm" ]
tramadol is a CHEMICAL
15509185_task0
Sentence: Clinical pharmacology of tramadol. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL
[ "O", "O", "O", "B-CHEMICAL", "O" ]
Clinical pharmacology of tramadol.
[ "Clinical", "pharmacology", "of", "tramadol", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
tramadol is a CHEMICAL
15509185_task1
Sentence: Clinical pharmacology of tramadol. Instructions: please typing these entity words according to sentence: tramadol Options: CHEMICAL
[ "O", "O", "O", "B-CHEMICAL", "O" ]
Clinical pharmacology of tramadol.
[ "Clinical", "pharmacology", "of", "tramadol", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
tramadol
15509185_task2
Sentence: Clinical pharmacology of tramadol. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-CHEMICAL", "O" ]
Clinical pharmacology of tramadol.
[ "Clinical", "pharmacology", "of", "tramadol", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Neuropeptide Y Y1 receptor is a GENE-Y, glutathione peroxidase is a GENE-N, c - AMP response element - binding protein is a GENE-N, phenylpropanolamine is a CHEMICAL
23052195_task0
Sentence: Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL, GENE-Y, GENE-N
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "O", "O", "O" ]
Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats.
[ "Neuropeptide", "Y", "Y1", "receptor", "knockdown", "can", "modify", "glutathione", "peroxidase", "and", "c", "-", "AMP", "response", "element", "-", "binding", "protein", "in", "phenylpropanolamine", "-", "treated", "rats", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Neuropeptide Y Y1 receptor is a GENE-Y, glutathione peroxidase is a GENE-N, c - AMP response element - binding protein is a GENE-N, phenylpropanolamine is a CHEMICAL
23052195_task1
Sentence: Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats. Instructions: please typing these entity words according to sentence: Neuropeptide Y Y1 receptor, glutathione peroxidase, c - AMP response element - binding protein, phenylpropanolamine Options: CHEMICAL, GENE-Y, GENE-N
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "O", "O", "O" ]
Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats.
[ "Neuropeptide", "Y", "Y1", "receptor", "knockdown", "can", "modify", "glutathione", "peroxidase", "and", "c", "-", "AMP", "response", "element", "-", "binding", "protein", "in", "phenylpropanolamine", "-", "treated", "rats", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Neuropeptide Y Y1 receptor, glutathione peroxidase, c - AMP response element - binding protein, phenylpropanolamine
23052195_task2
Sentence: Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats. Instructions: please extract entity words from the input sentence
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "O", "O", "O" ]
Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element-binding protein in phenylpropanolamine-treated rats.
[ "Neuropeptide", "Y", "Y1", "receptor", "knockdown", "can", "modify", "glutathione", "peroxidase", "and", "c", "-", "AMP", "response", "element", "-", "binding", "protein", "in", "phenylpropanolamine", "-", "treated", "rats", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Milz is an umlsterm, Literatur is an umlsterm, Drainage is an umlsterm, Patienten is an umlsterm, maennlich is an umlsterm, weiblich is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Trokartechnik is an umlsterm, Sonnenberg - Drainage is an umlsterm, Patienten is an umlsterm, Drainagebehandlung is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Patienten is an umlsterm, Morbus Crohn is an umlsterm, Fistel is an umlsterm, Colon is an umlsterm, Milz is an umlsterm, Splenektomie is an umlsterm, Drainage is an umlsterm, Milzhaematoms is an umlsterm, Komplikationen is an umlsterm, Blutung is an umlsterm, Verletzung is an umlsterm, Pleura is an umlsterm, Colon is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Milzerhaltung is an umlsterm, Belastung is an umlsterm, Patienten is an umlsterm, Methode is an umlsterm
DerChirurg.70680744.ger.abstr_task0
Sentence: Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv .
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[ "umlsterm" ]
Milz is an umlsterm, Literatur is an umlsterm, Drainage is an umlsterm, Patienten is an umlsterm, maennlich is an umlsterm, weiblich is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Trokartechnik is an umlsterm, Sonnenberg - Drainage is an umlsterm, Patienten is an umlsterm, Drainagebehandlung is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Patienten is an umlsterm, Morbus Crohn is an umlsterm, Fistel is an umlsterm, Colon is an umlsterm, Milz is an umlsterm, Splenektomie is an umlsterm, Drainage is an umlsterm, Milzhaematoms is an umlsterm, Komplikationen is an umlsterm, Blutung is an umlsterm, Verletzung is an umlsterm, Pleura is an umlsterm, Colon is an umlsterm, Patienten is an umlsterm, Drainage is an umlsterm, Milzerhaltung is an umlsterm, Belastung is an umlsterm, Patienten is an umlsterm, Methode is an umlsterm
DerChirurg.70680744.ger.abstr_task1
Sentence: Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv . Instructions: please typing these entity words according to sentence: Milz, Literatur, Drainage, Patienten, maennlich, weiblich, Patienten, Drainage, Trokartechnik, Sonnenberg - Drainage, Patienten, Drainagebehandlung, Patienten, Drainage, Patienten, Morbus Crohn, Fistel, Colon, Milz, Splenektomie, Drainage, Milzhaematoms, Komplikationen, Blutung, Verletzung, Pleura, Colon, Patienten, Drainage, Milzerhaltung, Belastung, Patienten, Methode Options: umlsterm
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Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv .
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[ "umlsterm" ]
Milz, Literatur, Drainage, Patienten, maennlich, weiblich, Patienten, Drainage, Trokartechnik, Sonnenberg - Drainage, Patienten, Drainagebehandlung, Patienten, Drainage, Patienten, Morbus Crohn, Fistel, Colon, Milz, Splenektomie, Drainage, Milzhaematoms, Komplikationen, Blutung, Verletzung, Pleura, Colon, Patienten, Drainage, Milzerhaltung, Belastung, Patienten, Methode
DerChirurg.70680744.ger.abstr_task2
Sentence: Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Wegen der Seltenheit von Abscessen in der Milz und der Vulnerabilitaet des Organs werden in der Literatur nur wenige Fallbeschreibungen ueber die percutane Drainage von Milzabscessen gefunden . Wir berichten ueber 8 Patienten ( 3 maennlich , 5 weiblich , Durchschnittsalter 74,1 +/- 10,76 Jahre ) , bei denen grosse Milzabscesse vorlagen und die in den letzten 5 Jahren in unserer Klinik behandelt wurden . Ergebnis : Bei allen acht Patienten war es moeglich , eine sonographisch gesteuerte percutane Drainage durchzufuehren ( Trokartechnik , van Sonnenberg-Drainage 12-16 French , Abscessinhalt 70-750 ml ) . Von den 7 Patienten , bei denen die Drainagebehandlung definitiv zum Erfolg fuehrte , musste bei 2 Patienten eine 2. Drainage wegen eines Rezidivabscesses eingelegt werden . Bei einem Patienten mit Morbus Crohn verhinderte eine Fistel zwischen Colon und drainiertem Milzabscess die definitive Ausheilung . Die Untersuchung der Milz nach Splenektomie zeigte jedoch eine komplette Drainage des infizierten Milzhaematoms . Komplikationen wie Blutung oder Verletzung von Pleura oder Colon traten bei unseren Patienten nicht auf . Die Vorteile der percutan sonographisch gesteuerten Drainage sind Milzerhaltung , : keine Keimverschleppung intraabdominell , geringe Belastung vor allem der multimorbiden Patienten mit hohem Operationsrisiko . Die Methode ist nach unserer Erfahrung komplikationsarm und effektiv .
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[ "umlsterm" ]
Behandlung is an umlsterm, Prostatahyperplasie is an umlsterm, Plazeboeffekt is an umlsterm, Kuerbiskern- is an umlsterm, Roggenpollenextrakte is an umlsterm, Phytosterole is an umlsterm, Phytotherapie is an umlsterm, Prostatawachstums is an umlsterm
DerUrologeA.70360010.ger.abstr_task0
Sentence: Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen .
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[ "umlsterm" ]
Behandlung is an umlsterm, Prostatahyperplasie is an umlsterm, Plazeboeffekt is an umlsterm, Kuerbiskern- is an umlsterm, Roggenpollenextrakte is an umlsterm, Phytosterole is an umlsterm, Phytotherapie is an umlsterm, Prostatawachstums is an umlsterm
DerUrologeA.70360010.ger.abstr_task1
Sentence: Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen . Instructions: please typing these entity words according to sentence: Behandlung, Prostatahyperplasie, Plazeboeffekt, Kuerbiskern-, Roggenpollenextrakte, Phytosterole, Phytotherapie, Prostatawachstums Options: umlsterm
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Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen .
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[ "umlsterm" ]
Behandlung, Prostatahyperplasie, Plazeboeffekt, Kuerbiskern-, Roggenpollenextrakte, Phytosterole, Phytotherapie, Prostatawachstums
DerUrologeA.70360010.ger.abstr_task2
Sentence: Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen . Instructions: please extract entity words from the input sentence
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Phytopharmaka haben seit langem einen festen Platz in der Behandlung der Miktionsbeschwerden bei benigner Prostatahyperplasie ( BPH ) . Trotzdem blieben bis in die juengste Vergangenheit Zweifel , ob ihre Wirksamkeit ueber einen Plazeboeffekt hinausgeht . In diesem Artikel werden die wichtigsten Phytopharmaka zur BPH-Therapie ( Saegepalmen- Brennesselwurzel- , Kuerbiskern- und Roggenpollenextrakte sowie " Phytosterole " , unterschiedlicher Herkunft ) vorgestellt . Ferner werden die Ergebnisse klinischer Studien sowie von In-vitro-Untersuchungen zur Aufklaerung moeglicher Wirkprinzipien geschildert . Die neueren klinischen Studien zeigen fuer eine Reihe von Phytopharmaka einen signifikanten Vorteil gegenueber Plazebo . Dies rechtfertigt den Einsatz der Phytotherapie zur Linderung der Symptome in den fruehen Stadien der BPH . Eine signifikante Hemmung des weiteren Prostatawachstums kann aber nicht erwartet werden . Regelmaessige Verlaufskontrollen sind daher unerlaesslich , um den Zeitpunkt fuer eine evtl. notwendig werdende Operation nicht zu verpassen .
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[ "umlsterm" ]
GW433908 is a CHEMICAL, amprenavir is a CHEMICAL
14693528_task0
Sentence: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.
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[ "GENE-N", "CHEMICAL" ]
GW433908 is a CHEMICAL, amprenavir is a CHEMICAL
14693528_task1
Sentence: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Instructions: please typing these entity words according to sentence: GW433908, amprenavir Options: CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.
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[ "GENE-N", "CHEMICAL" ]
GW433908, amprenavir
14693528_task2
Sentence: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]
Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.
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[ "GENE-N", "CHEMICAL" ]
Psychoanalyse is an umlsterm, Psychotherapie is an umlsterm, Ich - Pathologie is an umlsterm, Charakteranalyse is an umlsterm, Koerperhaltungen is an umlsterm, Affektabwehr is an umlsterm, Arbeit is an umlsterm, Affekte is an umlsterm, lebensgeschichtlichen is an umlsterm, Koerperpsychotherapie is an umlsterm, Bioenergetik is an umlsterm, Biosynthese is an umlsterm, Psychotherapieverfahren is an umlsterm, Therapie is an umlsterm, Koerperpsychotherapie is an umlsterm, Arbeit is an umlsterm
Psychotherapeut.70420092.ger.abstr_task0
Sentence: Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten .
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[ "umlsterm" ]
Psychoanalyse is an umlsterm, Psychotherapie is an umlsterm, Ich - Pathologie is an umlsterm, Charakteranalyse is an umlsterm, Koerperhaltungen is an umlsterm, Affektabwehr is an umlsterm, Arbeit is an umlsterm, Affekte is an umlsterm, lebensgeschichtlichen is an umlsterm, Koerperpsychotherapie is an umlsterm, Bioenergetik is an umlsterm, Biosynthese is an umlsterm, Psychotherapieverfahren is an umlsterm, Therapie is an umlsterm, Koerperpsychotherapie is an umlsterm, Arbeit is an umlsterm
Psychotherapeut.70420092.ger.abstr_task1
Sentence: Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten . Instructions: please typing these entity words according to sentence: Psychoanalyse, Psychotherapie, Ich - Pathologie, Charakteranalyse, Koerperhaltungen, Affektabwehr, Arbeit, Affekte, lebensgeschichtlichen, Koerperpsychotherapie, Bioenergetik, Biosynthese, Psychotherapieverfahren, Therapie, Koerperpsychotherapie, Arbeit Options: umlsterm
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Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten .
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[ "umlsterm" ]
Psychoanalyse, Psychotherapie, Ich - Pathologie, Charakteranalyse, Koerperhaltungen, Affektabwehr, Arbeit, Affekte, lebensgeschichtlichen, Koerperpsychotherapie, Bioenergetik, Biosynthese, Psychotherapieverfahren, Therapie, Koerperpsychotherapie, Arbeit
Psychotherapeut.70420092.ger.abstr_task2
Sentence: Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Wilhelm Reich schuf seit den 20er Jahren aus der Psychoanalyse heraus die Grundlage fuer eine koerperbezogene Psychotherapie . Er ging dabei von Ueberlegungen zur Ich-Pathologie , zur Sexualfunktion und zur Widerstands- und Charakteranalyse aus . Charakterliche Haltungen und Koerperhaltungen verstand er als Muster einer Affektabwehr , die nicht nur psychisch , sondern auch koerperlich erfolgt . So kam er dazu , ueber die Arbeit an muskulaeren Verspannungen und am Koerperausdruck abgewehrte Affekte zu mobilisieren , zu ihrem lebensgeschichtlichen Sinn vorzudringen und damit Selbstheilungsprozesse einzuleiten . Auf diesen Ansatz , gebundene affektive Energie freizusetzen und neu zu integrieren , gehen die neoreichianischen Schulen der Koerperpsychotherapie wie Bioenergetik , Biodynamik , Biosynthese u.a. zurueck , deren Menschenbild und Heilungstheorie den Humanistischen Psychotherapieverfahren nahesteht . Koerperliche Prozesse werden mit als Indikatoren fuer Verlauf und Erfolg einer Therapie genutzt , daneben finden sich in der modernen Koerperpsychotherapie Ansaetze zur Arbeit mit dem Koerper im Beziehungs- und Uebertragungsgeschehen und Ueberlegungen zur Reintegration mit psychoanalytischen Konzepten .
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[ "umlsterm" ]
dDAVP is a compound, aquaporin-2 is a protein
DS.d1569_task0
Sentence: Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes.
[ "Following", "dDAVP", "there", "was", "a", "time", "-", "dependent", "redistribution", "of", "total", "aquaporin-2", "from", "predominantly", "intracellular", "vesicles", "to", "the", "apical", "plasma", "membrane", ",", "clathrin", "-", "coated", "vesicles", ",", "early", "endosomal", "compartments", ",", "and", "lysosomes", "." ]
[ "protein", "compound" ]
dDAVP is a compound, aquaporin-2 is a protein
DS.d1569_task1
Sentence: Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes. Instructions: please typing these entity words according to sentence: dDAVP, aquaporin-2 Options: compound, protein
[ "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes.
[ "Following", "dDAVP", "there", "was", "a", "time", "-", "dependent", "redistribution", "of", "total", "aquaporin-2", "from", "predominantly", "intracellular", "vesicles", "to", "the", "apical", "plasma", "membrane", ",", "clathrin", "-", "coated", "vesicles", ",", "early", "endosomal", "compartments", ",", "and", "lysosomes", "." ]
[ "protein", "compound" ]
dDAVP, aquaporin-2
DS.d1569_task2
Sentence: Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes. Instructions: please extract entity words from the input sentence
[ "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes.
[ "Following", "dDAVP", "there", "was", "a", "time", "-", "dependent", "redistribution", "of", "total", "aquaporin-2", "from", "predominantly", "intracellular", "vesicles", "to", "the", "apical", "plasma", "membrane", ",", "clathrin", "-", "coated", "vesicles", ",", "early", "endosomal", "compartments", ",", "and", "lysosomes", "." ]
[ "protein", "compound" ]
clofarabine is a DRUG, clofarabine is a DRUG, CLOLAR is a BRAND, CLOLAR is a BRAND
Clofarabine_ddi_task0
Sentence: Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: BRAND, DRUG
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O" ]
Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR .
[ "Although", "no", "clinical", "drug", "-", "drug", "interaction", "studies", "have", "been", "conducted", "to", "date", ",", "on", "the", "basis", "of", "the", "in", "vitro", "studies", ",", "cytochrome", "p450", "inhibitors", "and", "inducers", "are", "unlikely", "to", "affect", "the", "metabolism", "of", "clofarabine", ".", "The", "effect", "of", "clofarabine", "on", "the", "metabolism", "of", "cytochrome", "p450", "substrates", "has", "not", "been", "studied", ".", "Drug", "/", "Laboratory", "Tests", "Interactions", "There", "are", "no", "known", "clinically", "significant", "interactions", "of", "CLOLAR", " ", "with", "other", "medications", "or", "laboratory", "tests", ".", "No", "formal", "drug", "/", "laboratory", "test", "interaction", "studies", "have", "been", "conducted", "with", "CLOLAR", " ", "." ]
[ "DRUG", "BRAND" ]
clofarabine is a DRUG, clofarabine is a DRUG, CLOLAR is a BRAND, CLOLAR is a BRAND
Clofarabine_ddi_task1
Sentence: Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR . Instructions: please typing these entity words according to sentence: clofarabine, clofarabine, CLOLAR, CLOLAR Options: BRAND, DRUG
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O" ]
Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR .
[ "Although", "no", "clinical", "drug", "-", "drug", "interaction", "studies", "have", "been", "conducted", "to", "date", ",", "on", "the", "basis", "of", "the", "in", "vitro", "studies", ",", "cytochrome", "p450", "inhibitors", "and", "inducers", "are", "unlikely", "to", "affect", "the", "metabolism", "of", "clofarabine", ".", "The", "effect", "of", "clofarabine", "on", "the", "metabolism", "of", "cytochrome", "p450", "substrates", "has", "not", "been", "studied", ".", "Drug", "/", "Laboratory", "Tests", "Interactions", "There", "are", "no", "known", "clinically", "significant", "interactions", "of", "CLOLAR", " ", "with", "other", "medications", "or", "laboratory", "tests", ".", "No", "formal", "drug", "/", "laboratory", "test", "interaction", "studies", "have", "been", "conducted", "with", "CLOLAR", " ", "." ]
[ "DRUG", "BRAND" ]
clofarabine, clofarabine, CLOLAR, CLOLAR
Clofarabine_ddi_task2
Sentence: Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O" ]
Although no clinical drug-drug interaction studies have been conducted to date, on the basis of the in vitro studies, cytochrome p450 inhibitors and inducers are unlikely to affect the metabolism of clofarabine. The effect of clofarabine on the metabolism of cytochrome p450 substrates has not been studied. Drug/Laboratory Tests Interactions There are no known clinically significant interactions of CLOLAR with other medications or laboratory tests. No formal drug/laboratory test interaction studies have been conducted with CLOLAR .
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[ "DRUG", "BRAND" ]
Risikoabschaetzung is an umlsterm, Morbiditaet is an umlsterm, gezielte is an umlsterm, Therapie is an umlsterm, Notfallsituation is an umlsterm, gegebenen is an umlsterm, Rolle is an umlsterm, Risikoabschaetzung is an umlsterm, Ernaehrungszustand is an umlsterm, Nierenfunktion is an umlsterm, Patienten is an umlsterm, Boden is an umlsterm, Diagnostik is an umlsterm, Risikoabschaetzung is an umlsterm, Oesophagektomie is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Patienten is an umlsterm
DerChirurg.70680654.ger.abstr_task0
Sentence: Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert .
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[ "umlsterm" ]
Risikoabschaetzung is an umlsterm, Morbiditaet is an umlsterm, gezielte is an umlsterm, Therapie is an umlsterm, Notfallsituation is an umlsterm, gegebenen is an umlsterm, Rolle is an umlsterm, Risikoabschaetzung is an umlsterm, Ernaehrungszustand is an umlsterm, Nierenfunktion is an umlsterm, Patienten is an umlsterm, Boden is an umlsterm, Diagnostik is an umlsterm, Risikoabschaetzung is an umlsterm, Oesophagektomie is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Patienten is an umlsterm
DerChirurg.70680654.ger.abstr_task1
Sentence: Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert . Instructions: please typing these entity words according to sentence: Risikoabschaetzung, Morbiditaet, gezielte, Therapie, Notfallsituation, gegebenen, Rolle, Risikoabschaetzung, Ernaehrungszustand, Nierenfunktion, Patienten, Boden, Diagnostik, Risikoabschaetzung, Oesophagektomie, Patienten, Risiko, Patienten Options: umlsterm
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Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert .
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[ "umlsterm" ]
Risikoabschaetzung, Morbiditaet, gezielte, Therapie, Notfallsituation, gegebenen, Rolle, Risikoabschaetzung, Ernaehrungszustand, Nierenfunktion, Patienten, Boden, Diagnostik, Risikoabschaetzung, Oesophagektomie, Patienten, Risiko, Patienten
DerChirurg.70680654.ger.abstr_task2
Sentence: Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Ziel der praeoperativen Risikoabschaetzung ist die Senkung der postoperativen Morbiditaet und Letalitaet durch eine Identifizierung gestoerter Organfunktionen welche durch gezielte Massnahmen bereits praeoperativ oder durch eine problemorientierte postoperative Therapie verbessert werden koennen . Die praeoperative Risikoerfassung nimmt damit Einfluss auf die Operationsindikation , den Operationszeitpunkt , die Verfahrenswahl und das postoperative Management . Eine notwendige Voraussetzung dafuer ist es , relevante Organfunktionen mit moeglichem Einfluss auf den postoperativen Verlauf zu erfassen und diese im Hinblick auf den geplanten Eingriff zu bewerten . Dieses Vorgehen gewinnt vor allem bei den heute immer umfangreicheren elektiven chirurgischen Eingriffen zunehmend an Bedeutung . In der Notfallsituation muessen dagegen die gegebenen Rahmenbedingungen in der Regel akzeptiert werden , so dass hier der praeoperativen Risikoabklaerung eine untergeordnete Rolle zukommt . Die objektive Risikoabschaetzung erfolgt durch die Erfassung mit Bewertung von Lebensalter , Allgemein- und Ernaehrungszustand , pulmonale kardiovasculaere , hepatische und Nierenfunktion , , sowie Kooperationsfaehigkeit des Patienten . Je nach Art und Umfang des geplanten Eingriffs kommt den einzelnen Organfunktionen eine unterschiedliche Bedeutung zu . Auf dem Boden von Basisuntersuchungen und erweiterter Diagnostik wird eine praeoperative Risikoabschaetzung moeglich . Allgemeingueltige und aus mehreren Faktoren zusammengesetzten Klassifikationssysteme zur Identifizierung von Risikogruppen haben sich mit Ausnahme einzelner und auf bestimmte Eingriffe zugeschnittene Risiko-Scores , in der klinischen Anwendung bisher jedoch nicht breit durchgesetzt . Am Modell der Oesophagektomie beim Patienten mit Oesophaguscarinom konnten wir jedoch modellhaft zeigen , dass eine quantitative Aussage ueber das peri- und postoperative Risiko des Patienten anhand physiologischer und praeoperativ verfuegbarer Parameter moeglich ist und sich durch den konsequenten Einsatz eines validierten Risiko-Score-Systems die postoperative Letalitaet deutlich senken laesst . Die Entwicklung und Validierung aehnlicher Score-Systeme fuer andere Eingriffe erscheint damit wuenschenswert .
[ "Zusammenfassung", ".", "Ziel", "der", "praeoperativen", "Risikoabschaetzung", "ist", "die", "Senkung", "der", "postoperativen", "Morbiditaet", "und", "Letalitaet", "durch", "eine", "Identifizierung", "gestoerter", "Organfunktionen", "welche", "durch", "gezielte", "Massnahmen", "bereits", "praeoperativ", "oder", "durch", "eine", "problemorientierte", "postoperative", "Therapie", "verbessert", "werden", "koennen", ".", "Die", "praeoperative", "Risikoerfassung", "nimmt", "damit", "Einfluss", "auf", "die", "Operationsindikation", ",", "den", "Operationszeitpunkt", ",", "die", "Verfahrenswahl", "und", "das", "postoperative", "Management", ".", "Eine", "notwendige", "Voraussetzung", "dafuer", "ist", "es", ",", "relevante", "Organfunktionen", "mit", "moeglichem", "Einfluss", "auf", "den", "postoperativen", "Verlauf", "zu", "erfassen", "und", "diese", "im", "Hinblick", "auf", "den", "geplanten", "Eingriff", "zu", "bewerten", ".", "Dieses", "Vorgehen", "gewinnt", "vor", "allem", "bei", "den", "heute", "immer", "umfangreicheren", "elektiven", "chirurgischen", "Eingriffen", "zunehmend", "an", "Bedeutung", ".", "In", "der", "Notfallsituation", "muessen", "dagegen", "die", "gegebenen", "Rahmenbedingungen", "in", "der", "Regel", "akzeptiert", "werden", ",", "so", "dass", "hier", "der", "praeoperativen", "Risikoabklaerung", "eine", "untergeordnete", "Rolle", "zukommt", ".", "Die", "objektive", "Risikoabschaetzung", "erfolgt", "durch", "die", "Erfassung", "mit", "Bewertung", "von", "Lebensalter", ",", "Allgemein-", "und", "Ernaehrungszustand", ",", "pulmonale", "kardiovasculaere", ",", "hepatische", "und", "Nierenfunktion", ",", ",", "sowie", "Kooperationsfaehigkeit", "des", "Patienten", ".", "Je", "nach", "Art", "und", "Umfang", "des", "geplanten", "Eingriffs", "kommt", "den", "einzelnen", "Organfunktionen", "eine", "unterschiedliche", "Bedeutung", "zu", ".", "Auf", "dem", "Boden", "von", "Basisuntersuchungen", "und", "erweiterter", "Diagnostik", "wird", "eine", "praeoperative", "Risikoabschaetzung", "moeglich", ".", "Allgemeingueltige", "und", "aus", "mehreren", "Faktoren", "zusammengesetzten", "Klassifikationssysteme", "zur", "Identifizierung", "von", "Risikogruppen", "haben", "sich", "mit", "Ausnahme", "einzelner", "und", "auf", "bestimmte", "Eingriffe", "zugeschnittene", "Risiko", "-", "Scores", ",", "in", "der", "klinischen", "Anwendung", "bisher", "jedoch", "nicht", "breit", "durchgesetzt", ".", "Am", "Modell", "der", "Oesophagektomie", "beim", "Patienten", "mit", "Oesophaguscarinom", "konnten", "wir", "jedoch", "modellhaft", "zeigen", ",", "dass", "eine", "quantitative", "Aussage", "ueber", "das", "peri-", "und", "postoperative", "Risiko", "des", "Patienten", "anhand", "physiologischer", "und", "praeoperativ", "verfuegbarer", "Parameter", "moeglich", "ist", "und", "sich", "durch", "den", "konsequenten", "Einsatz", "eines", "validierten", "Risiko", "-", "Score", "-", "Systems", "die", "postoperative", "Letalitaet", "deutlich", "senken", "laesst", ".", "Die", "Entwicklung", "und", "Validierung", "aehnlicher", "Score", "-", "Systeme", "fuer", "andere", "Eingriffe", "erscheint", "damit", "wuenschenswert", "." ]
[ "umlsterm" ]
thrombectomy is an umlsterm, internal carotid artery is an umlsterm, woman is an umlsterm, ovarian hyperstimulation syndrome is an umlsterm, after treatment is an umlsterm, fertilization is an umlsterm, transient is an umlsterm, hemiparesis is an umlsterm, thrombus is an umlsterm, internal carotid artery is an umlsterm, Open is an umlsterm, surgical treatment is an umlsterm, thrombectomy is an umlsterm, symptoms is an umlsterm
DerChirurg.80691105.eng.abstr_task0
Sentence: We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]
We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms .
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[ "umlsterm" ]
thrombectomy is an umlsterm, internal carotid artery is an umlsterm, woman is an umlsterm, ovarian hyperstimulation syndrome is an umlsterm, after treatment is an umlsterm, fertilization is an umlsterm, transient is an umlsterm, hemiparesis is an umlsterm, thrombus is an umlsterm, internal carotid artery is an umlsterm, Open is an umlsterm, surgical treatment is an umlsterm, thrombectomy is an umlsterm, symptoms is an umlsterm
DerChirurg.80691105.eng.abstr_task1
Sentence: We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms . Instructions: please typing these entity words according to sentence: thrombectomy, internal carotid artery, woman, ovarian hyperstimulation syndrome, after treatment, fertilization, transient, hemiparesis, thrombus, internal carotid artery, Open, surgical treatment, thrombectomy, symptoms Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]
We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms .
[ "We", "report", "the", "successful", "thrombectomy", "of", "the", "internal", "carotid", "artery", ".", "A", "33-year", "-", "old", "woman", "suffered", "from", "ovarian", "hyperstimulation", "syndrome", "after", "treatment", "with", "FSH", "/", "HCG", "for", "in", "-", "vitro", "fertilization", ".", "She", "developed", "a", "transient", "left", "hemiparesis", ".", "This", "was", "caused", "by", "a", "floating", "thrombus", "located", "in", "the", "internal", "carotid", "artery", ".", "Open", "surgical", "treatment", "with", "thrombectomy", "prevents", "recurrent", "neurological", "symptoms", "." ]
[ "umlsterm" ]
thrombectomy, internal carotid artery, woman, ovarian hyperstimulation syndrome, after treatment, fertilization, transient, hemiparesis, thrombus, internal carotid artery, Open, surgical treatment, thrombectomy, symptoms
DerChirurg.80691105.eng.abstr_task2
Sentence: We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]
We report the successful thrombectomy of the internal carotid artery . A 33-year-old woman suffered from ovarian hyperstimulation syndrome after treatment with FSH/HCG for in-vitro fertilization . She developed a transient left hemiparesis . This was caused by a floating thrombus located in the internal carotid artery . Open surgical treatment with thrombectomy prevents recurrent neurological symptoms .
[ "We", "report", "the", "successful", "thrombectomy", "of", "the", "internal", "carotid", "artery", ".", "A", "33-year", "-", "old", "woman", "suffered", "from", "ovarian", "hyperstimulation", "syndrome", "after", "treatment", "with", "FSH", "/", "HCG", "for", "in", "-", "vitro", "fertilization", ".", "She", "developed", "a", "transient", "left", "hemiparesis", ".", "This", "was", "caused", "by", "a", "floating", "thrombus", "located", "in", "the", "internal", "carotid", "artery", ".", "Open", "surgical", "treatment", "with", "thrombectomy", "prevents", "recurrent", "neurological", "symptoms", "." ]
[ "umlsterm" ]
betamethasone is a CHEMICAL, 11beta hydroxysteroid dehydrogenase types 1 and 2 is a GENE-N, glucocorticoid receptor is a GENE-Y
15866114_task0
Sentence: The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O" ]
The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta.
[ "The", "effects", "of", "chorioamnionitis", "and", "betamethasone", "on", "11beta", "hydroxysteroid", "dehydrogenase", "types", "1", "and", "2", "and", "the", "glucocorticoid", "receptor", "in", "preterm", "human", "placenta", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
betamethasone is a CHEMICAL, 11beta hydroxysteroid dehydrogenase types 1 and 2 is a GENE-N, glucocorticoid receptor is a GENE-Y
15866114_task1
Sentence: The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta. Instructions: please typing these entity words according to sentence: betamethasone, 11beta hydroxysteroid dehydrogenase types 1 and 2, glucocorticoid receptor Options: GENE-Y, GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O" ]
The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta.
[ "The", "effects", "of", "chorioamnionitis", "and", "betamethasone", "on", "11beta", "hydroxysteroid", "dehydrogenase", "types", "1", "and", "2", "and", "the", "glucocorticoid", "receptor", "in", "preterm", "human", "placenta", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
betamethasone, 11beta hydroxysteroid dehydrogenase types 1 and 2, glucocorticoid receptor
15866114_task2
Sentence: The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O" ]
The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta.
[ "The", "effects", "of", "chorioamnionitis", "and", "betamethasone", "on", "11beta", "hydroxysteroid", "dehydrogenase", "types", "1", "and", "2", "and", "the", "glucocorticoid", "receptor", "in", "preterm", "human", "placenta", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
equivocal is a Negation, rupture of membranes is a Condition, advanced labor is a Condition, intrauterine infection is a Condition, vaginal bleeding is a Condition, non reassuring is a Qualifier, fetal heart rate is a Measurement
NCT02548013_exc_task0
Sentence: 1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Measurement, Condition, Negation, Qualifier
[ "O", "O", "O", "O", "B-Negation", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O" ]
1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate.
[ "1", ".", "Patient", "with", "equivocal", "diagnosis", "of", "rupture", "of", "membranes", "\n", "2", ".", "advanced", "labor", "\n", "3", ".", "intrauterine", "infection", "\n", "4", ".", "vaginal", "bleeding", "or", "\n", "5", ".", "non", "reassuring", "fetal", "heart", "rate", ".", " \n \n" ]
[ "Condition", "Measurement", "Qualifier", "Negation" ]
equivocal is a Negation, rupture of membranes is a Condition, advanced labor is a Condition, intrauterine infection is a Condition, vaginal bleeding is a Condition, non reassuring is a Qualifier, fetal heart rate is a Measurement
NCT02548013_exc_task1
Sentence: 1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate. Instructions: please typing these entity words according to sentence: equivocal, rupture of membranes, advanced labor, intrauterine infection, vaginal bleeding, non reassuring, fetal heart rate Options: Measurement, Condition, Negation, Qualifier
[ "O", "O", "O", "O", "B-Negation", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O" ]
1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate.
[ "1", ".", "Patient", "with", "equivocal", "diagnosis", "of", "rupture", "of", "membranes", "\n", "2", ".", "advanced", "labor", "\n", "3", ".", "intrauterine", "infection", "\n", "4", ".", "vaginal", "bleeding", "or", "\n", "5", ".", "non", "reassuring", "fetal", "heart", "rate", ".", " \n \n" ]
[ "Condition", "Measurement", "Qualifier", "Negation" ]
equivocal, rupture of membranes, advanced labor, intrauterine infection, vaginal bleeding, non reassuring, fetal heart rate
NCT02548013_exc_task2
Sentence: 1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-Negation", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O" ]
1. Patient with equivocal diagnosis of rupture of membranes 2. advanced labor 3. intrauterine infection 4. vaginal bleeding or 5. non reassuring fetal heart rate.
[ "1", ".", "Patient", "with", "equivocal", "diagnosis", "of", "rupture", "of", "membranes", "\n", "2", ".", "advanced", "labor", "\n", "3", ".", "intrauterine", "infection", "\n", "4", ".", "vaginal", "bleeding", "or", "\n", "5", ".", "non", "reassuring", "fetal", "heart", "rate", ".", " \n \n" ]
[ "Condition", "Measurement", "Qualifier", "Negation" ]
Estrone is a lipid, myeloid cell differentiation is an other_name, 17 beta - hydroxysteroid dehydrogenase is a protein_molecule
47061_task0
Sentence: Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: lipid, protein_molecule, other_name
[ "B-lipid", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O" ]
Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.
[ "Estrone", "potentiates", "myeloid", "cell", "differentiation", ":", "a", "role", "for", "17", "beta", "-", "hydroxysteroid", "dehydrogenase", "in", "modulating", "hemopoiesis", "." ]
[ "other_name", "protein_molecule", "lipid", "cell_type", "other_organic_compound", "protein_family_or_group", "cell_line", "RNA_family_or_group" ]
Estrone is a lipid, myeloid cell differentiation is an other_name, 17 beta - hydroxysteroid dehydrogenase is a protein_molecule
47061_task1
Sentence: Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis. Instructions: please typing these entity words according to sentence: Estrone, myeloid cell differentiation, 17 beta - hydroxysteroid dehydrogenase Options: lipid, protein_molecule, other_name
[ "B-lipid", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O" ]
Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.
[ "Estrone", "potentiates", "myeloid", "cell", "differentiation", ":", "a", "role", "for", "17", "beta", "-", "hydroxysteroid", "dehydrogenase", "in", "modulating", "hemopoiesis", "." ]
[ "other_name", "protein_molecule", "lipid", "cell_type", "other_organic_compound", "protein_family_or_group", "cell_line", "RNA_family_or_group" ]
Estrone, myeloid cell differentiation, 17 beta - hydroxysteroid dehydrogenase
47061_task2
Sentence: Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis. Instructions: please extract entity words from the input sentence
[ "B-lipid", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O" ]
Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.
[ "Estrone", "potentiates", "myeloid", "cell", "differentiation", ":", "a", "role", "for", "17", "beta", "-", "hydroxysteroid", "dehydrogenase", "in", "modulating", "hemopoiesis", "." ]
[ "other_name", "protein_molecule", "lipid", "cell_type", "other_organic_compound", "protein_family_or_group", "cell_line", "RNA_family_or_group" ]
EAR is an umlsterm, aneurysms is an umlsterm, EAR is an umlsterm, surgical treatment is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm, EAR is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm, mortality is an umlsterm, morbidity is an umlsterm, multivariate analysis is an umlsterm, mortality is an umlsterm, Mortality is an umlsterm, survival rate is an umlsterm, classification is an umlsterm, period is an umlsterm, Multivariate analysis is an umlsterm, arterial occlusive disease is an umlsterm, age is an umlsterm, mortality is an umlsterm, Implantation is an umlsterm, internal mammary artery is an umlsterm, survival rate is an umlsterm, mortality is an umlsterm, mortality is an umlsterm, EAR is an umlsterm, procedure is an umlsterm, choice is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm
ZfuerKardiologie.00890754.eng.abstr_task0
Sentence: Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]
Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms .
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[ "umlsterm" ]
EAR is an umlsterm, aneurysms is an umlsterm, EAR is an umlsterm, surgical treatment is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm, EAR is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm, mortality is an umlsterm, morbidity is an umlsterm, multivariate analysis is an umlsterm, mortality is an umlsterm, Mortality is an umlsterm, survival rate is an umlsterm, classification is an umlsterm, period is an umlsterm, Multivariate analysis is an umlsterm, arterial occlusive disease is an umlsterm, age is an umlsterm, mortality is an umlsterm, Implantation is an umlsterm, internal mammary artery is an umlsterm, survival rate is an umlsterm, mortality is an umlsterm, mortality is an umlsterm, EAR is an umlsterm, procedure is an umlsterm, choice is an umlsterm, patients is an umlsterm, aneurysms is an umlsterm
ZfuerKardiologie.00890754.eng.abstr_task1
Sentence: Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms . Instructions: please typing these entity words according to sentence: EAR, aneurysms, EAR, surgical treatment, patients, aneurysms, EAR, patients, aneurysms, mortality, morbidity, multivariate analysis, mortality, Mortality, survival rate, classification, period, Multivariate analysis, arterial occlusive disease, age, mortality, Implantation, internal mammary artery, survival rate, mortality, mortality, EAR, procedure, choice, patients, aneurysms Options: umlsterm
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Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms .
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[ "umlsterm" ]
EAR, aneurysms, EAR, surgical treatment, patients, aneurysms, EAR, patients, aneurysms, mortality, morbidity, multivariate analysis, mortality, Mortality, survival rate, classification, period, Multivariate analysis, arterial occlusive disease, age, mortality, Implantation, internal mammary artery, survival rate, mortality, mortality, EAR, procedure, choice, patients, aneurysms
ZfuerKardiologie.00890754.eng.abstr_task2
Sentence: Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms . Instructions: please extract entity words from the input sentence
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Endoaneurysmorrhaphy ( EAR ) in postinfarct ventricular aneurysms leads to excellent short-term results . However , the temporal response of EAR is widely unknown . Thus , the indication for surgical treatment of patients with ventricular aneurysms is not well defined . EAR was performed in 157 patients ( 6/1993-6/1999 ) with symptomatic ventricular aneurysms ( median NYHA III ) . Factors influencing cardiac mortality and morbidity during follow-up were determined by univariate and multivariate analysis . Perioperative mortality was low : 5% . Mortality during follow-up was 3.3% per year , resulting in a 5-year survival rate of 78% . NYHA classification ameliorated significantly from the preoperative status compared to the follow-up period ( median NYHA II ; p 0.001 ) . Multivariate analysis identified preexisting arterial occlusive disease and advanced age ( > 70 years ) as significant factors influencing medium-term mortality . Implantation of the left internal mammary artery was associated with a better survival rate . Endoaneurysmorrhaphy can be performed with low perioperative mortality , will result in a significant amelioration of the cardiac clinical status and offers low medium-term mortality . Our data indicate that EAR seems to be the procedure of choice for patients with symptomatic ventricular aneurysms .
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[ "umlsterm" ]
Oct-1 is a Protein, Oct-2 is a Protein, Oct-1 is a Protein, Oct-2 is a Protein, Oct-1 is a Protein, Oct-2 is a Protein
652_task0
Sentence: Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus.
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[ "Protein" ]
Oct-1 is a Protein, Oct-2 is a Protein, Oct-1 is a Protein, Oct-2 is a Protein, Oct-1 is a Protein, Oct-2 is a Protein
652_task1
Sentence: Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus. Instructions: please typing these entity words according to sentence: Oct-1, Oct-2, Oct-1, Oct-2, Oct-1, Oct-2 Options: Protein
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Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus.
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[ "Protein" ]
Oct-1, Oct-2, Oct-1, Oct-2, Oct-1, Oct-2
652_task2
Sentence: Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes. The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro. To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation. We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter. We also find significant differences in activation of germline and V region promoters by kappa enhancers. Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation. These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus.
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[ "Protein" ]
Fyn is a protein, Src is a protein, Crkl SH3 domains is a protein-domain, Csk SH3 domain is a protein-domain, EVL is a protein
1.0alpha7.train.960_task0
Sentence: The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-domain, protein
[ "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]
The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL.
[ "The", " ", "Fyn", ",", " ", "Src", ",", "and", " ", "Crkl", "SH3", "domains", "were", "poorly", "bound", ",", "whereas", "the", " ", "Csk", "SH3", "domain", "failed", "to", "bind", "detectable", "levels", "of", " ", "EVL", "." ]
[ "protein-domain", "protein" ]
Fyn is a protein, Src is a protein, Crkl SH3 domains is a protein-domain, Csk SH3 domain is a protein-domain, EVL is a protein
1.0alpha7.train.960_task1
Sentence: The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL. Instructions: please typing these entity words according to sentence: Fyn, Src, Crkl SH3 domains, Csk SH3 domain, EVL Options: protein-domain, protein
[ "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]
The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL.
[ "The", " ", "Fyn", ",", " ", "Src", ",", "and", " ", "Crkl", "SH3", "domains", "were", "poorly", "bound", ",", "whereas", "the", " ", "Csk", "SH3", "domain", "failed", "to", "bind", "detectable", "levels", "of", " ", "EVL", "." ]
[ "protein-domain", "protein" ]
Fyn, Src, Crkl SH3 domains, Csk SH3 domain, EVL
1.0alpha7.train.960_task2
Sentence: The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]
The Fyn, Src, and Crkl SH3 domains were poorly bound, whereas the Csk SH3 domain failed to bind detectable levels of EVL.
[ "The", " ", "Fyn", ",", " ", "Src", ",", "and", " ", "Crkl", "SH3", "domains", "were", "poorly", "bound", ",", "whereas", "the", " ", "Csk", "SH3", "domain", "failed", "to", "bind", "detectable", "levels", "of", " ", "EVL", "." ]
[ "protein-domain", "protein" ]
Chronic is a Multiplier, opiate is a Drug, Liver disease is a Condition, history of hepatitis B or C , cirrhosis , nonalcoholic steatohepatitis , history of alcoholism , ALT / AST greater than 3 times upper limit of normal in the past 3 months is a Scope, Allergy / hypersensitivity is a Scope, acetaminophen is a Drug, baseline is a Temporal, dementia is a Condition, Chronic is a Qualifier, diathesis is a Condition, Chronic is a Qualifier, kidney disease is a Condition
NCT02369211_exc_task0
Sentence: Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Multiplier, Scope, Drug
[ "B-Multiplier", "B-Drug", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "B-Condition", "O", "B-Qualifier", "B-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O" ]
Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease
[ "Chronic", "opiate", "use", "\n", "Liver", "disease", "(", "known", "history", "of", "hepatitis", "B", "or", "C", ",", "cirrhosis", ",", "nonalcoholic", "steatohepatitis", ",", "history", "of", "alcoholism", ",", "ALT", "/", "AST", "greater", "than", "3", "times", "upper", "limit", "of", "normal", "in", "the", "past", "3", "months", ")", "\n", "Allergy", "/", "hypersensitivity", "to", "acetaminophen", "\n", "Patients", "with", "baseline", "dementia", "\n", "Chronic", "diathesis", "\n", "Chronic", "kidney", "disease", "\n" ]
[ "Scope", "Value", "Condition", "Temporal", "Drug", "Multiplier", "Observation", "Measurement", "Qualifier" ]
Chronic is a Multiplier, opiate is a Drug, Liver disease is a Condition, history of hepatitis B or C , cirrhosis , nonalcoholic steatohepatitis , history of alcoholism , ALT / AST greater than 3 times upper limit of normal in the past 3 months is a Scope, Allergy / hypersensitivity is a Scope, acetaminophen is a Drug, baseline is a Temporal, dementia is a Condition, Chronic is a Qualifier, diathesis is a Condition, Chronic is a Qualifier, kidney disease is a Condition
NCT02369211_exc_task1
Sentence: Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease Instructions: please typing these entity words according to sentence: Chronic, opiate, Liver disease, history of hepatitis B or C , cirrhosis , nonalcoholic steatohepatitis , history of alcoholism , ALT / AST greater than 3 times upper limit of normal in the past 3 months, Allergy / hypersensitivity, acetaminophen, baseline, dementia, Chronic, diathesis, Chronic, kidney disease Options: Temporal, Condition, Qualifier, Multiplier, Scope, Drug
[ "B-Multiplier", "B-Drug", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "B-Condition", "O", "B-Qualifier", "B-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O" ]
Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease
[ "Chronic", "opiate", "use", "\n", "Liver", "disease", "(", "known", "history", "of", "hepatitis", "B", "or", "C", ",", "cirrhosis", ",", "nonalcoholic", "steatohepatitis", ",", "history", "of", "alcoholism", ",", "ALT", "/", "AST", "greater", "than", "3", "times", "upper", "limit", "of", "normal", "in", "the", "past", "3", "months", ")", "\n", "Allergy", "/", "hypersensitivity", "to", "acetaminophen", "\n", "Patients", "with", "baseline", "dementia", "\n", "Chronic", "diathesis", "\n", "Chronic", "kidney", "disease", "\n" ]
[ "Scope", "Value", "Condition", "Temporal", "Drug", "Multiplier", "Observation", "Measurement", "Qualifier" ]
Chronic, opiate, Liver disease, history of hepatitis B or C , cirrhosis , nonalcoholic steatohepatitis , history of alcoholism , ALT / AST greater than 3 times upper limit of normal in the past 3 months, Allergy / hypersensitivity, acetaminophen, baseline, dementia, Chronic, diathesis, Chronic, kidney disease
NCT02369211_exc_task2
Sentence: Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease Instructions: please extract entity words from the input sentence
[ "B-Multiplier", "B-Drug", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "B-Condition", "O", "B-Qualifier", "B-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O" ]
Chronic opiate use Liver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months) Allergy/hypersensitivity to acetaminophen Patients with baseline dementia Chronic diathesis Chronic kidney disease
[ "Chronic", "opiate", "use", "\n", "Liver", "disease", "(", "known", "history", "of", "hepatitis", "B", "or", "C", ",", "cirrhosis", ",", "nonalcoholic", "steatohepatitis", ",", "history", "of", "alcoholism", ",", "ALT", "/", "AST", "greater", "than", "3", "times", "upper", "limit", "of", "normal", "in", "the", "past", "3", "months", ")", "\n", "Allergy", "/", "hypersensitivity", "to", "acetaminophen", "\n", "Patients", "with", "baseline", "dementia", "\n", "Chronic", "diathesis", "\n", "Chronic", "kidney", "disease", "\n" ]
[ "Scope", "Value", "Condition", "Temporal", "Drug", "Multiplier", "Observation", "Measurement", "Qualifier" ]
IL-2R associated JAK / STAT proteins is a protein_family_or_group, HTLV - I(+ ) , IL-2-independent and IL-2-dependent cell lines is a (AND cell_line cell_line cell_line), uncultured leukemic cells is a cell_type, patients is a multi_cell, adult T - cell lymphoma / leukemia is an other_name
41626_task0
Sentence: Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: multi_cell, cell_type, (AND cell_line cell_line cell_line), other_name, protein_family_or_group
[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
[ "Differences", "in", "phosphorylation", "of", "the", "IL-2R", "associated", "JAK", "/", "STAT", "proteins", "between", "HTLV", "-", "I(+", ")", ",", "IL-2-independent", "and", "IL-2-dependent", "cell", "lines", "and", "uncultured", "leukemic", "cells", "from", "patients", "with", "adult", "T", "-", "cell", "lymphoma", "/", "leukemia", "." ]
[ "(AND cell_line cell_line cell_line)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "protein_molecule", "", "other_organic_compound", "multi_cell", "virus" ]
IL-2R associated JAK / STAT proteins is a protein_family_or_group, HTLV - I(+ ) , IL-2-independent and IL-2-dependent cell lines is a (AND cell_line cell_line cell_line), uncultured leukemic cells is a cell_type, patients is a multi_cell, adult T - cell lymphoma / leukemia is an other_name
41626_task1
Sentence: Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia. Instructions: please typing these entity words according to sentence: IL-2R associated JAK / STAT proteins, HTLV - I(+ ) , IL-2-independent and IL-2-dependent cell lines, uncultured leukemic cells, patients, adult T - cell lymphoma / leukemia Options: multi_cell, cell_type, (AND cell_line cell_line cell_line), other_name, protein_family_or_group
[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
[ "Differences", "in", "phosphorylation", "of", "the", "IL-2R", "associated", "JAK", "/", "STAT", "proteins", "between", "HTLV", "-", "I(+", ")", ",", "IL-2-independent", "and", "IL-2-dependent", "cell", "lines", "and", "uncultured", "leukemic", "cells", "from", "patients", "with", "adult", "T", "-", "cell", "lymphoma", "/", "leukemia", "." ]
[ "(AND cell_line cell_line cell_line)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "protein_molecule", "", "other_organic_compound", "multi_cell", "virus" ]
IL-2R associated JAK / STAT proteins, HTLV - I(+ ) , IL-2-independent and IL-2-dependent cell lines, uncultured leukemic cells, patients, adult T - cell lymphoma / leukemia
41626_task2
Sentence: Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "I-(AND cell_line cell_line cell_line)", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
[ "Differences", "in", "phosphorylation", "of", "the", "IL-2R", "associated", "JAK", "/", "STAT", "proteins", "between", "HTLV", "-", "I(+", ")", ",", "IL-2-independent", "and", "IL-2-dependent", "cell", "lines", "and", "uncultured", "leukemic", "cells", "from", "patients", "with", "adult", "T", "-", "cell", "lymphoma", "/", "leukemia", "." ]
[ "(AND cell_line cell_line cell_line)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "protein_molecule", "", "other_organic_compound", "multi_cell", "virus" ]
signal transmission pathways is an other_name, T lymphocytes is a cell_type, immunophilin is a protein_molecule, FK506 is an other_organic_compound, rapamycin is an other_organic_compound
96331_task0
Sentence: Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_organic_compound, cell_type, protein_molecule, other_name
[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "O", "O", "B-other_organic_compound", "O", "B-other_organic_compound", "O" ]
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
[ "Two", "distinct", "signal", "transmission", "pathways", "in", "T", "lymphocytes", "are", "inhibited", "by", "complexes", "formed", "between", "an", "immunophilin", "and", "either", "FK506", "or", "rapamycin", "." ]
[ "other_name", "protein_family_or_group", "protein_substructure", "(AND peptide peptide)", "protein_molecule", "peptide", "cell_type", "other_organic_compound", "DNA_domain_or_region", "" ]
signal transmission pathways is an other_name, T lymphocytes is a cell_type, immunophilin is a protein_molecule, FK506 is an other_organic_compound, rapamycin is an other_organic_compound
96331_task1
Sentence: Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Instructions: please typing these entity words according to sentence: signal transmission pathways, T lymphocytes, immunophilin, FK506, rapamycin Options: other_organic_compound, cell_type, protein_molecule, other_name
[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "O", "O", "B-other_organic_compound", "O", "B-other_organic_compound", "O" ]
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
[ "Two", "distinct", "signal", "transmission", "pathways", "in", "T", "lymphocytes", "are", "inhibited", "by", "complexes", "formed", "between", "an", "immunophilin", "and", "either", "FK506", "or", "rapamycin", "." ]
[ "other_name", "protein_family_or_group", "protein_substructure", "(AND peptide peptide)", "protein_molecule", "peptide", "cell_type", "other_organic_compound", "DNA_domain_or_region", "" ]
signal transmission pathways, T lymphocytes, immunophilin, FK506, rapamycin
96331_task2
Sentence: Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "O", "O", "B-other_organic_compound", "O", "B-other_organic_compound", "O" ]
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
[ "Two", "distinct", "signal", "transmission", "pathways", "in", "T", "lymphocytes", "are", "inhibited", "by", "complexes", "formed", "between", "an", "immunophilin", "and", "either", "FK506", "or", "rapamycin", "." ]
[ "other_name", "protein_family_or_group", "protein_substructure", "(AND peptide peptide)", "protein_molecule", "peptide", "cell_type", "other_organic_compound", "DNA_domain_or_region", "" ]
bone transplantation is an umlsterm, procedure is an umlsterm, crest is an umlsterm, scapula is an umlsterm, fibula is an umlsterm, donor is an umlsterm, tumor - related is an umlsterm, defects is an umlsterm, osteoradionecrosis is an umlsterm, defects is an umlsterm, trauma is an umlsterm, atrophy is an umlsterm, future is an umlsterm, techniques is an umlsterm, transplantation is an umlsterm, surgery is an umlsterm, transplants is an umlsterm
MundKieferGesichtschirurgie.0004s322.eng.abstr_task0
Sentence: Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants .
[ "Microvascular", "bone", "transplantation", "has", "become", "a", "routine", "procedure", ".", "The", "iliac", "crest", ",", "scapula", ",", "and", "fibula", "are", "the", "most", "common", "donor", "sites", ".", "These", "are", "used", "for", "reconstruction", "of", "tumor", "-", "related", "defects", "or", "after", "osteoradionecrosis", ".", "But", "additional", "indications", "have", "been", "developed", "as", "defects", "after", "trauma", ",", "extreme", "atrophy", ",", "or", "hemifacial", "microsomia", ".", "In", "the", "future", ",", "three", "-", "dimensional", "techniques", "will", "improve", "transplantation", "surgery", "and", "will", "enable", "the", "prefabrication", "of", "transplants", "." ]
[ "umlsterm" ]
bone transplantation is an umlsterm, procedure is an umlsterm, crest is an umlsterm, scapula is an umlsterm, fibula is an umlsterm, donor is an umlsterm, tumor - related is an umlsterm, defects is an umlsterm, osteoradionecrosis is an umlsterm, defects is an umlsterm, trauma is an umlsterm, atrophy is an umlsterm, future is an umlsterm, techniques is an umlsterm, transplantation is an umlsterm, surgery is an umlsterm, transplants is an umlsterm
MundKieferGesichtschirurgie.0004s322.eng.abstr_task1
Sentence: Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants . Instructions: please typing these entity words according to sentence: bone transplantation, procedure, crest, scapula, fibula, donor, tumor - related, defects, osteoradionecrosis, defects, trauma, atrophy, future, techniques, transplantation, surgery, transplants Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants .
[ "Microvascular", "bone", "transplantation", "has", "become", "a", "routine", "procedure", ".", "The", "iliac", "crest", ",", "scapula", ",", "and", "fibula", "are", "the", "most", "common", "donor", "sites", ".", "These", "are", "used", "for", "reconstruction", "of", "tumor", "-", "related", "defects", "or", "after", "osteoradionecrosis", ".", "But", "additional", "indications", "have", "been", "developed", "as", "defects", "after", "trauma", ",", "extreme", "atrophy", ",", "or", "hemifacial", "microsomia", ".", "In", "the", "future", ",", "three", "-", "dimensional", "techniques", "will", "improve", "transplantation", "surgery", "and", "will", "enable", "the", "prefabrication", "of", "transplants", "." ]
[ "umlsterm" ]
bone transplantation, procedure, crest, scapula, fibula, donor, tumor - related, defects, osteoradionecrosis, defects, trauma, atrophy, future, techniques, transplantation, surgery, transplants
MundKieferGesichtschirurgie.0004s322.eng.abstr_task2
Sentence: Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Microvascular bone transplantation has become a routine procedure . The iliac crest , scapula , and fibula are the most common donor sites . These are used for reconstruction of tumor-related defects or after osteoradionecrosis . But additional indications have been developed as defects after trauma , extreme atrophy , or hemifacial microsomia . In the future , three-dimensional techniques will improve transplantation surgery and will enable the prefabrication of transplants .
[ "Microvascular", "bone", "transplantation", "has", "become", "a", "routine", "procedure", ".", "The", "iliac", "crest", ",", "scapula", ",", "and", "fibula", "are", "the", "most", "common", "donor", "sites", ".", "These", "are", "used", "for", "reconstruction", "of", "tumor", "-", "related", "defects", "or", "after", "osteoradionecrosis", ".", "But", "additional", "indications", "have", "been", "developed", "as", "defects", "after", "trauma", ",", "extreme", "atrophy", ",", "or", "hemifacial", "microsomia", ".", "In", "the", "future", ",", "three", "-", "dimensional", "techniques", "will", "improve", "transplantation", "surgery", "and", "will", "enable", "the", "prefabrication", "of", "transplants", "." ]
[ "umlsterm" ]
Genetic predisposition is an umlsterm, breast cancer is an umlsterm, susceptibility is an umlsterm, genes is an umlsterm, breast cancer is an umlsterm, BRCA1 is an umlsterm, genes is an umlsterm, genes is an umlsterm, function is an umlsterm, testing is an umlsterm, BRCA1 is an umlsterm, disease is an umlsterm, risk is an umlsterm, women is an umlsterm, family is an umlsterm, history is an umlsterm, breast cancer is an umlsterm, prevention is an umlsterm, treatment is an umlsterm, breast cancer is an umlsterm
DerChirurg.90700373.eng.abstr_task0
Sentence: Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer .
[ "Genetic", "predisposition", "is", "responsible", "for", "5", "-", "10", "%", "of", "all", "breast", "cancer", ".", "Within", "the", "past", "10", "years", "the", "major", "susceptibility", "genes", "for", "breast", "cancer", ",", "BRCA1", "and", "BRCA2", ",", "have", "been", "identified", ".", "Both", "genes", "are", "considered", "to", "be", "tumor", "-", "suppressor", "genes", ",", "but", "their", "function", "is", "poorly", "understood", ".", "Current", "genetic", "testing", "for", "mutated", "BRCA1", "and", "BRCA2", "is", "the", "basis", "for", "estimating", "disease", "risk", "for", "women", "with", "a", "strong", "family", "history", "of", "breast", "cancer", "and", "will", "provide", "important", "information", "on", "the", "prevention", "and", "treatment", "of", "familial", "breast", "cancer", "." ]
[ "umlsterm" ]
Genetic predisposition is an umlsterm, breast cancer is an umlsterm, susceptibility is an umlsterm, genes is an umlsterm, breast cancer is an umlsterm, BRCA1 is an umlsterm, genes is an umlsterm, genes is an umlsterm, function is an umlsterm, testing is an umlsterm, BRCA1 is an umlsterm, disease is an umlsterm, risk is an umlsterm, women is an umlsterm, family is an umlsterm, history is an umlsterm, breast cancer is an umlsterm, prevention is an umlsterm, treatment is an umlsterm, breast cancer is an umlsterm
DerChirurg.90700373.eng.abstr_task1
Sentence: Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer . Instructions: please typing these entity words according to sentence: Genetic predisposition, breast cancer, susceptibility, genes, breast cancer, BRCA1, genes, genes, function, testing, BRCA1, disease, risk, women, family, history, breast cancer, prevention, treatment, breast cancer Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer .
[ "Genetic", "predisposition", "is", "responsible", "for", "5", "-", "10", "%", "of", "all", "breast", "cancer", ".", "Within", "the", "past", "10", "years", "the", "major", "susceptibility", "genes", "for", "breast", "cancer", ",", "BRCA1", "and", "BRCA2", ",", "have", "been", "identified", ".", "Both", "genes", "are", "considered", "to", "be", "tumor", "-", "suppressor", "genes", ",", "but", "their", "function", "is", "poorly", "understood", ".", "Current", "genetic", "testing", "for", "mutated", "BRCA1", "and", "BRCA2", "is", "the", "basis", "for", "estimating", "disease", "risk", "for", "women", "with", "a", "strong", "family", "history", "of", "breast", "cancer", "and", "will", "provide", "important", "information", "on", "the", "prevention", "and", "treatment", "of", "familial", "breast", "cancer", "." ]
[ "umlsterm" ]
Genetic predisposition, breast cancer, susceptibility, genes, breast cancer, BRCA1, genes, genes, function, testing, BRCA1, disease, risk, women, family, history, breast cancer, prevention, treatment, breast cancer
DerChirurg.90700373.eng.abstr_task2
Sentence: Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer . Instructions: please extract entity words from the input sentence
[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Genetic predisposition is responsible for 5-10 % of all breast cancer . Within the past 10 years the major susceptibility genes for breast cancer , BRCA1 and BRCA2, have been identified . Both genes are considered to be tumor-suppressor genes , but their function is poorly understood . Current genetic testing for mutated BRCA1 and BRCA2 is the basis for estimating disease risk for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer .
[ "Genetic", "predisposition", "is", "responsible", "for", "5", "-", "10", "%", "of", "all", "breast", "cancer", ".", "Within", "the", "past", "10", "years", "the", "major", "susceptibility", "genes", "for", "breast", "cancer", ",", "BRCA1", "and", "BRCA2", ",", "have", "been", "identified", ".", "Both", "genes", "are", "considered", "to", "be", "tumor", "-", "suppressor", "genes", ",", "but", "their", "function", "is", "poorly", "understood", ".", "Current", "genetic", "testing", "for", "mutated", "BRCA1", "and", "BRCA2", "is", "the", "basis", "for", "estimating", "disease", "risk", "for", "women", "with", "a", "strong", "family", "history", "of", "breast", "cancer", "and", "will", "provide", "important", "information", "on", "the", "prevention", "and", "treatment", "of", "familial", "breast", "cancer", "." ]
[ "umlsterm" ]
Y. enterocolitica is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, P. luminescens is a Organism, X. nematophilus is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, AI-2 is a Protein, PAS-4 is a Protein, LuxR is a Protein, c - di - GMP is a Chemical, human is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, M. sexta is a Organism, Y. enterocolitica is a Organism, Y. enterocolitica is a Organism, Y. pestis is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism
16_task0
Sentence: Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Chemical, Organism, Protein
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Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work.
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[ "Organism", "Chemical", "Protein" ]
Y. enterocolitica is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, P. luminescens is a Organism, X. nematophilus is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, AI-2 is a Protein, PAS-4 is a Protein, LuxR is a Protein, c - di - GMP is a Chemical, human is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism, Y. enterocolitica is a Organism, M. sexta is a Organism, Y. enterocolitica is a Organism, Y. enterocolitica is a Organism, Y. pestis is a Organism, Y. enterocolitica is a Organism, P. luminescens is a Organism
16_task1
Sentence: Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work. Instructions: please typing these entity words according to sentence: Y. enterocolitica, P. luminescens, Y. enterocolitica, P. luminescens, P. luminescens, X. nematophilus, Y. enterocolitica, P. luminescens, AI-2, PAS-4, LuxR, c - di - GMP, human, P. luminescens, Y. enterocolitica, P. luminescens, Y. enterocolitica, M. sexta, Y. enterocolitica, Y. enterocolitica, Y. pestis, Y. enterocolitica, P. luminescens Options: Chemical, Organism, Protein
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Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work.
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[ "Organism", "Chemical", "Protein" ]
Y. enterocolitica, P. luminescens, Y. enterocolitica, P. luminescens, P. luminescens, X. nematophilus, Y. enterocolitica, P. luminescens, AI-2, PAS-4, LuxR, c - di - GMP, human, P. luminescens, Y. enterocolitica, P. luminescens, Y. enterocolitica, M. sexta, Y. enterocolitica, Y. enterocolitica, Y. pestis, Y. enterocolitica, P. luminescens
16_task2
Sentence: Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work. Instructions: please extract entity words from the input sentence
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Conclusion The comparison of Y. enterocolitica and P. luminescens at the genomic level performed here provides the database for a better understanding of the genetic basis for their distinct behaviour towards invertebrates and mammals. Y. enterocolitica is expected to switch between two pathogenicity phases against insects and mammalians, while the genome of P. luminescens must contain the modulators and regulators necessary to change the bacterium from a state of symbiosis with nematodes to pathogenicity against insects, and also from symbiosis-proficient primary variants to symbiosis-deficient secondary variants [17]. Those adaptational processes must be precisely regulated by the bacteria. It was assumed that there are parallels in the regulation of pathogenicity in mammals and insect pathogens [41,123]. However, molecular components of the regulatory networks controlling pathogenicity and mutualism have recently been demonstrated to be very different between P. luminescens and X. nematophilus with similar life cycles [124]. Dissecting the genomes of Y. enterocolitica and P. luminescens for putative key regulators, we identified factor groups (AI-2, PAS-4/LuxR like receptors) possibly involved in pathogen-insect association only, those with members contributing to either insect or mammalian pathogenicity (QS, TKS, Usp), and c-di-GMP signalling probably not involved in regulation of activities against insects. Certainly, the question whether fundamental differences in regulatory networks reflect how each of these two bacteria specifically interacts with either the insect or the human host remains to be addressed in more detail. Bioconversion of its insect hosts is an important stage in the lifecycle of P. luminescens. This fact might explain the high number of antibacterial factors directed against possible competitors that are going to colonize the same insect cadaver or that are already present in the insect gut flora [17]. However, no corresponding determinants were identified in the genome of Y. enterocolitica. Moreover, P. luminescens is pathogenic to a variety of insect larvae, and a dose of <5 colony-forming units directly injected into the blood system is sufficient to kill within 48-72 h [124]. In contrast, only highly concentrated protein extracts of Y. enterocolitica are toxic for M. sexta [7], and a low insect larvae mortality has been observed following injection of approximately 3.5 x 106 Y. enterocolitica cells into the hemolymph (T. M. Fuchs, unpublished data). This data strongly suggests that Y. enterocolitica, similar to Y. pestis, has developed a strategy to infect and proliferate in insects, and use these organisms rather as transmission vectors than as pure nutrient source. Summarizing, Y. enterocolitica and P. luminescens have evolved partially different and partially similar and therefore probably conserved mechanisms to detect and to react on the insect host. Up to the present time, we are far away from understanding the complexity of bacteria-invertebrate interactions. With the genome comparison carried out here, however, we uncovered several genes which are promising candidate genes involved in insect association and pathogenicity, and therefore created a promising basis for future experimental work.
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[ "Organism", "Chemical", "Protein" ]
Opioide is an umlsterm, Deutschland is an umlsterm, Patienten is an umlsterm, Tumorschmerzen is an umlsterm, niedergelassenen Aerzte is an umlsterm, Analgetika is an umlsterm, Tumorpatienten is an umlsterm, Medikamente is an umlsterm, Patienten is an umlsterm, Tumorerkrankung is an umlsterm, Patienten is an umlsterm, Schmerzen is an umlsterm, Schmerztherapie is an umlsterm, Tumorpatienten is an umlsterm, Aerzten is an umlsterm, Patienten is an umlsterm, Aengste is an umlsterm, Risiken is an umlsterm
DerSchmerz.60100283.ger.abstr_task0
Sentence: Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen .
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[ "umlsterm" ]
Opioide is an umlsterm, Deutschland is an umlsterm, Patienten is an umlsterm, Tumorschmerzen is an umlsterm, niedergelassenen Aerzte is an umlsterm, Analgetika is an umlsterm, Tumorpatienten is an umlsterm, Medikamente is an umlsterm, Patienten is an umlsterm, Tumorerkrankung is an umlsterm, Patienten is an umlsterm, Schmerzen is an umlsterm, Schmerztherapie is an umlsterm, Tumorpatienten is an umlsterm, Aerzten is an umlsterm, Patienten is an umlsterm, Aengste is an umlsterm, Risiken is an umlsterm
DerSchmerz.60100283.ger.abstr_task1
Sentence: Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen . Instructions: please typing these entity words according to sentence: Opioide, Deutschland, Patienten, Tumorschmerzen, niedergelassenen Aerzte, Analgetika, Tumorpatienten, Medikamente, Patienten, Tumorerkrankung, Patienten, Schmerzen, Schmerztherapie, Tumorpatienten, Aerzten, Patienten, Aengste, Risiken Options: umlsterm
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Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen .
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[ "umlsterm" ]
Opioide, Deutschland, Patienten, Tumorschmerzen, niedergelassenen Aerzte, Analgetika, Tumorpatienten, Medikamente, Patienten, Tumorerkrankung, Patienten, Schmerzen, Schmerztherapie, Tumorpatienten, Aerzten, Patienten, Aengste, Risiken
DerSchmerz.60100283.ger.abstr_task2
Sentence: Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen . Instructions: please extract entity words from the input sentence
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Starke Opioide werden in Deutschland bei Patienten mit Tumorschmerzen extrem selten eingesetzt . In den Jahren 1988 und 1991 haben in der Region Hannover nur 16,2 % bzw. 19,5 % der niedergelassenen Aerzte derartige Analgetika verordnet . Von den Tumorpatienten , die ueberhaupt mit Opioiden versorgt wurden , erhielten 1988 nur 36,0 % und 1991 nur 32,1 % ihre Medikamente regelmaessig und kontinuierlich . Hochgerechnet auf die Gesamtzahl der Patienten mit einer Tumorerkrankung bedeutet dies , dass nur 14,5 % ( 1988 ) bzw. 19,0 % ( 1991 ) aller Patienten , bei denen opioidpflichtige Schmerzen bestanden , im ambulanten Bereich suffizient mit Opioidanalgetika versorgt wurden . Die Ursachen fuer die restriktive Verschreibung von Opioiden und damit fuer die Defizite in der Schmerztherapie bei Tumorpatienten sind vielschichtig . Zum einen bestehen bei vielen Aerzten , erstaunlicherweise aber auch bei den betroffenen Patienten selber , irrationale Aengste vor Nebenwirkungen und Risiken einer Opioidmedikation . Ein weiterer wichtiger Grund sind die gesetzlichen Bestimmungen , die bei der Verordnung von Opioiden beachtet werden muessen .
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[ "umlsterm" ]
Ammonia is a CHEMICAL
17513636_task0
Sentence: Ammonia has anesthetic properties. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL
[ "B-CHEMICAL", "O", "O", "O", "O" ]
Ammonia has anesthetic properties.
[ "Ammonia", "has", "anesthetic", "properties", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Ammonia is a CHEMICAL
17513636_task1
Sentence: Ammonia has anesthetic properties. Instructions: please typing these entity words according to sentence: Ammonia Options: CHEMICAL
[ "B-CHEMICAL", "O", "O", "O", "O" ]
Ammonia has anesthetic properties.
[ "Ammonia", "has", "anesthetic", "properties", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Ammonia
17513636_task2
Sentence: Ammonia has anesthetic properties. Instructions: please extract entity words from the input sentence
[ "B-CHEMICAL", "O", "O", "O", "O" ]
Ammonia has anesthetic properties.
[ "Ammonia", "has", "anesthetic", "properties", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
GLP-1 receptor is a GENE-Y, glucagon - like peptide-1 receptor is a GENE-Y, glycosylated hemoglobin is a GENE-Y, A1C is a GENE-Y, glucose is a CHEMICAL, insulin is a GENE-Y, glucagon is a GENE-Y, dipeptidyl peptidase-4 is a GENE-Y, albumin is a GENE-Y, metformin is a CHEMICAL, sulfonylureas is a CHEMICAL, thiazolidinediones is a CHEMICAL, insulin is a GENE-Y, sitagliptin is a CHEMICAL, glimepiride is a CHEMICAL, insulin is a GENE-Y, insulin is a GENE-Y, A1C is a GENE-Y, A1C is a GENE-Y, pioglitazone is a CHEMICAL, A1C is a GENE-Y
6471_task0
Sentence: Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL
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Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs.
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[ "GENE-Y", "CHEMICAL" ]
GLP-1 receptor is a GENE-Y, glucagon - like peptide-1 receptor is a GENE-Y, glycosylated hemoglobin is a GENE-Y, A1C is a GENE-Y, glucose is a CHEMICAL, insulin is a GENE-Y, glucagon is a GENE-Y, dipeptidyl peptidase-4 is a GENE-Y, albumin is a GENE-Y, metformin is a CHEMICAL, sulfonylureas is a CHEMICAL, thiazolidinediones is a CHEMICAL, insulin is a GENE-Y, sitagliptin is a CHEMICAL, glimepiride is a CHEMICAL, insulin is a GENE-Y, insulin is a GENE-Y, A1C is a GENE-Y, A1C is a GENE-Y, pioglitazone is a CHEMICAL, A1C is a GENE-Y
6471_task1
Sentence: Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs. Instructions: please typing these entity words according to sentence: GLP-1 receptor, glucagon - like peptide-1 receptor, glycosylated hemoglobin, A1C, glucose, insulin, glucagon, dipeptidyl peptidase-4, albumin, metformin, sulfonylureas, thiazolidinediones, insulin, sitagliptin, glimepiride, insulin, insulin, A1C, A1C, pioglitazone, A1C Options: GENE-Y, CHEMICAL
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Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs.
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[ "GENE-Y", "CHEMICAL" ]
GLP-1 receptor, glucagon - like peptide-1 receptor, glycosylated hemoglobin, A1C, glucose, insulin, glucagon, dipeptidyl peptidase-4, albumin, metformin, sulfonylureas, thiazolidinediones, insulin, sitagliptin, glimepiride, insulin, insulin, A1C, A1C, pioglitazone, A1C
6471_task2
Sentence: Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs. Instructions: please extract entity words from the input sentence
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Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of albiglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in type 2 diabetes (T2D). DATA SOURCES: A MEDLINE search (1950-June 2014) was conducted using the keyword albiglutide. References were reviewed to identify additional sources. STUDY SELECTION AND DATA EXTRACTION: Articles evaluating pharmacokinetics, pharmacodynamics, safety, or efficacy of albiglutide were included. DATA SYNTHESIS: Albiglutide is a long-acting GLP-1 RA that lowers glycosylated hemoglobin (A1C) and reduces weight by stimulating glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and promoting satiety. Albiglutide has a long half-life as a result of resistance to degradation by dipeptidyl peptidase-4 and fusion to albumin, thus allowing once-weekly dosing. Albiglutide has been studied as monotherapy and add-on therapy to metformin, sulfonylureas, thiazolidinediones, insulin glargine, and varying combinations of these agents. Clinical studies have shown albiglutide to be superior to placebo, sitagliptin, and glimepiride and noninferior to insulin glargine and insulin lispro at reducing A1C in T2D patients, with A1C changes from baseline ranging from -0.55% to -0.9%. Noninferiority was not achieved when compared to liraglutide and pioglitazone. Weight changes ranged from +0.28 to -1.21 kg. The most common side effects are upper-respiratory-tract infections, diarrhea, nausea, and injection-site reactions. CONCLUSION: Albiglutide is the fourth GLP-1 RA approved in the United States. Advantages include once-weekly dosing and fewer gastrointestinal side effects compared with liraglutide, but it is less effective at reducing A1C and weight compared to liraglutide. It has not been compared head to head with other GLP-1 RAs.
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[ "GENE-Y", "CHEMICAL" ]
Sprunggelenk is an umlsterm, radiologischer is an umlsterm, Therapiekonzept is an umlsterm, Behandlung is an umlsterm, rheumatoider Arthritis is an umlsterm, Patienten is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, radiologischen is an umlsterm, Technik is an umlsterm
DerOrthopaede.90280785.ger.abstr_task0
Sentence: Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen .
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[ "umlsterm" ]
Sprunggelenk is an umlsterm, radiologischer is an umlsterm, Therapiekonzept is an umlsterm, Behandlung is an umlsterm, rheumatoider Arthritis is an umlsterm, Patienten is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, radiologischen is an umlsterm, Technik is an umlsterm
DerOrthopaede.90280785.ger.abstr_task1
Sentence: Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen . Instructions: please typing these entity words according to sentence: Sprunggelenk, radiologischer, Therapiekonzept, Behandlung, rheumatoider Arthritis, Patienten, Schmerz, Kontraindikationen, radiologischen, Technik Options: umlsterm
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Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen .
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[ "umlsterm" ]
Sprunggelenk, radiologischer, Therapiekonzept, Behandlung, rheumatoider Arthritis, Patienten, Schmerz, Kontraindikationen, radiologischen, Technik
DerOrthopaede.90280785.ger.abstr_task2
Sentence: Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen . Instructions: please extract entity words from the input sentence
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Es wird ueber Erfahrungen und Ergebnisse mit der Synovektomie und Radiosynoviorthese am oberen Sprunggelenk ( OSG ) berichtet . Ein gestaffeltes , das Ausmass radiologischer Veraenderungen beruecksichtigendes Therapiekonzept zur Behandlung des OSG bei rheumatoider Arthritis wird vorgestellt . Ergebnisse von 16 Patienten mit rheumatischem Befall des OSG zeigen , dass eine offene oder arthroskopische Synovektomie des OSG und additive Radiosynoviorthese ( RSO Schmerz und Gehfaehigkeit ) , nachhaltig positiv beeinflussen ; eine Progredienz klinischer Symptome des rheumatisch befallenen OSG wurde waehrend des Nachuntersuchungszeitraumes von 30 Monaten nicht beobachtet . Es wird empfohlen , nach Ausschluss von Kontraindikationen bei radiologischen OSG Veraenderungen der Stadien 0 , I und II nach Larsen et al. , die arthroskopische Synovektomie in Kombination mit einer RSO durchzufuehren . Die offene Synovektomie des OSG wird der arthroskopischen Technik nur bei gleichzeitig durchzufuehrender Tenosynovektomie vorgezogen .
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[ "umlsterm" ]
Alpha - B crystallin gene is a Gene, CRYAB is a Gene, CRYAB is a Gene, CRYAB is a Gene, 450delA is a SNP
340_task0
Sentence: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP
[ "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract.
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[ "Gene", "SNP" ]
Alpha - B crystallin gene is a Gene, CRYAB is a Gene, CRYAB is a Gene, CRYAB is a Gene, 450delA is a SNP
340_task1
Sentence: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract. Instructions: please typing these entity words according to sentence: Alpha - B crystallin gene, CRYAB, CRYAB, CRYAB, 450delA Options: Gene, SNP
[ "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract.
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[ "Gene", "SNP" ]
Alpha - B crystallin gene, CRYAB, CRYAB, CRYAB, 450delA
340_task2
Sentence: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract. Instructions: please extract entity words from the input sentence
[ "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Congenital cataracts are an important cause of bilateral visual impairment in infants. In a four-generation family of English descent, we mapped dominant congenital posterior polar cataract to chromosome 11q22-q22.3. The maximum LOD score, 3.92 at recombination fraction 0, was obtained for marker D11S898, near the gene that encodes crystallin alpha-B protein (CRYAB). By sequencing the coding regions of CRYAB, we found in exon 3 a deletion mutation, 450delA, that is associated with cataract in this family. The mutation resulted in a frameshift in codon 150 and produced an aberrant protein consisting of 184 residues. This is the first report of a mutation, in this gene, resulting in isolated congenital cataract.
[ "Alpha", "-", "B", "crystallin", "gene", "(", "CRYAB", ")", "mutation", "causes", "dominant", "congenital", "posterior", "polar", "cataract", "in", "humans", ".", "Congenital", "cataracts", "are", "an", "important", "cause", "of", "bilateral", "visual", "impairment", "in", "infants", ".", "In", "a", "four", "-", "generation", "family", "of", "English", "descent", ",", "we", "mapped", "dominant", "congenital", "posterior", "polar", "cataract", "to", "chromosome", "11q22-q22.3", ".", "The", "maximum", "LOD", "score", ",", "3.92", "at", "recombination", "fraction", "0", ",", "was", "obtained", "for", "marker", "D11S898", ",", "near", "the", "gene", "that", "encodes", "crystallin", "alpha", "-", "B", "protein", "(", "CRYAB", ")", ".", "By", "sequencing", "the", "coding", "regions", "of", "CRYAB", ",", "we", "found", "in", "exon", "3", "a", "deletion", "mutation", ",", "450delA", ",", "that", "is", "associated", "with", "cataract", "in", "this", "family", ".", "The", "mutation", "resulted", "in", "a", "frameshift", "in", "codon", "150", "and", "produced", "an", "aberrant", "protein", "consisting", "of", "184", "residues", ".", "This", "is", "the", "first", "report", "of", "a", "mutation", ",", "in", "this", "gene", ",", "resulting", "in", "isolated", "congenital", "cataract", ".", "\n" ]
[ "Gene", "SNP" ]
fibronectin is a protein, polystyrene is a compound
DS.d78_task0
Sentence: SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O" ]
SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene.
[ "SMC", "cultured", "on", "P(100/0", ")", "films", "modified", "by", "covalently", "attached", "fibronectin", "or", "fibrin", "layers", "proliferated", "at", "a", "rate", "comparable", "to", "that", "observed", "on", "control", "tissue", "culture", "polystyrene", "." ]
[ "protein", "compound" ]
fibronectin is a protein, polystyrene is a compound
DS.d78_task1
Sentence: SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene. Instructions: please typing these entity words according to sentence: fibronectin, polystyrene Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O" ]
SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene.
[ "SMC", "cultured", "on", "P(100/0", ")", "films", "modified", "by", "covalently", "attached", "fibronectin", "or", "fibrin", "layers", "proliferated", "at", "a", "rate", "comparable", "to", "that", "observed", "on", "control", "tissue", "culture", "polystyrene", "." ]
[ "protein", "compound" ]
fibronectin, polystyrene
DS.d78_task2
Sentence: SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O" ]
SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene.
[ "SMC", "cultured", "on", "P(100/0", ")", "films", "modified", "by", "covalently", "attached", "fibronectin", "or", "fibrin", "layers", "proliferated", "at", "a", "rate", "comparable", "to", "that", "observed", "on", "control", "tissue", "culture", "polystyrene", "." ]
[ "protein", "compound" ]
Hirnnerven is an umlsterm, Drainage is an umlsterm, Ligatur is an umlsterm, Hypertension is an umlsterm, Angiographie is an umlsterm, Tumorentfernung is an umlsterm, Gehoergangswand is an umlsterm, Ligatur is an umlsterm, Angiographie is an umlsterm
HNO.90470816.ger.abstr_task0
Sentence: Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte .
[ "Beidseitige", "Glomus", "-", "jugulare", "-", "Tumoren", "stellen", "eine", "Raritaet", "dar", ".", "Neben", "der", "Funktion", "des", "N.", "facialis", "muss", "bei", "ihrer", "Entfernung", "auch", "die", "Funktion", "der", "kaudalen", "Hirnnerven", "beruecksichtigt", "werden", ".", "Die", "Funktionserhaltung", "des", "Mittelohrs", "ist", "ebenfalls", "anzustreben", ",", "um", "einen", "beidseitigen", "Schalleitungsblock", "zu", "vermeiden", ".", "Die", "venoese", "zerebrale", "Drainage", "muss", "gesichert", "werden", ",", "da", "eine", "beidseitige", "Ligatur", "des", "Sinus", "sigmoideus", "zur", "zerebralen", "venoesen", "Hypertension", "fuehren", "wuerde", ".", "Am", "Beispiel", "eines", "grossen", "bilateralen", "Glomus", "-", "jugulare", "-", "Tumors", "der", "Klasse", "C2", "ermoeglichte", "die", "superselektive", "Angiographie", "und", "Embolisation", "die", "beidseitige", "vollstaendige", "Tumorentfernung", "ohne", "Funktionseinschraenkungen", "ueber", "einen", "transmastoidalen", "-", "transzervikalen", "Zugang", ".", "Durch", "temporaere", "Ventralverlagerung", "der", "hinteren", "Gehoergangswand", "gelang", "auch", "die", "Erhaltung", "der", "Mittelohrfunktion", ".", "Wegen", "der", "Ligatur", "der", "V.", "jugularis", "interna", "und", "des", "Sinus", "sigmoideus", "auf", "der", "1", ".", "Seite", "konnte", "die", "2", ".", "Seite", "erst", "1", "Jahr", "spaeter", "operiert", "werden", ",", "nachdem", "die", "Angiographie", "und", "Kompression", "der", "verbliebenen", "V.", "jugularis", "interna", "ausreichende", "venoese", "Kollateralen", "bestaetigt", "hatte", "." ]
[ "umlsterm" ]
Hirnnerven is an umlsterm, Drainage is an umlsterm, Ligatur is an umlsterm, Hypertension is an umlsterm, Angiographie is an umlsterm, Tumorentfernung is an umlsterm, Gehoergangswand is an umlsterm, Ligatur is an umlsterm, Angiographie is an umlsterm
HNO.90470816.ger.abstr_task1
Sentence: Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte . Instructions: please typing these entity words according to sentence: Hirnnerven, Drainage, Ligatur, Hypertension, Angiographie, Tumorentfernung, Gehoergangswand, Ligatur, Angiographie Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte .
[ "Beidseitige", "Glomus", "-", "jugulare", "-", "Tumoren", "stellen", "eine", "Raritaet", "dar", ".", "Neben", "der", "Funktion", "des", "N.", "facialis", "muss", "bei", "ihrer", "Entfernung", "auch", "die", "Funktion", "der", "kaudalen", "Hirnnerven", "beruecksichtigt", "werden", ".", "Die", "Funktionserhaltung", "des", "Mittelohrs", "ist", "ebenfalls", "anzustreben", ",", "um", "einen", "beidseitigen", "Schalleitungsblock", "zu", "vermeiden", ".", "Die", "venoese", "zerebrale", "Drainage", "muss", "gesichert", "werden", ",", "da", "eine", "beidseitige", "Ligatur", "des", "Sinus", "sigmoideus", "zur", "zerebralen", "venoesen", "Hypertension", "fuehren", "wuerde", ".", "Am", "Beispiel", "eines", "grossen", "bilateralen", "Glomus", "-", "jugulare", "-", "Tumors", "der", "Klasse", "C2", "ermoeglichte", "die", "superselektive", "Angiographie", "und", "Embolisation", "die", "beidseitige", "vollstaendige", "Tumorentfernung", "ohne", "Funktionseinschraenkungen", "ueber", "einen", "transmastoidalen", "-", "transzervikalen", "Zugang", ".", "Durch", "temporaere", "Ventralverlagerung", "der", "hinteren", "Gehoergangswand", "gelang", "auch", "die", "Erhaltung", "der", "Mittelohrfunktion", ".", "Wegen", "der", "Ligatur", "der", "V.", "jugularis", "interna", "und", "des", "Sinus", "sigmoideus", "auf", "der", "1", ".", "Seite", "konnte", "die", "2", ".", "Seite", "erst", "1", "Jahr", "spaeter", "operiert", "werden", ",", "nachdem", "die", "Angiographie", "und", "Kompression", "der", "verbliebenen", "V.", "jugularis", "interna", "ausreichende", "venoese", "Kollateralen", "bestaetigt", "hatte", "." ]
[ "umlsterm" ]
Hirnnerven, Drainage, Ligatur, Hypertension, Angiographie, Tumorentfernung, Gehoergangswand, Ligatur, Angiographie
HNO.90470816.ger.abstr_task2
Sentence: Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Beidseitige Glomus-jugulare-Tumoren stellen eine Raritaet dar . Neben der Funktion des N. facialis muss bei ihrer Entfernung auch die Funktion der kaudalen Hirnnerven beruecksichtigt werden . Die Funktionserhaltung des Mittelohrs ist ebenfalls anzustreben , um einen beidseitigen Schalleitungsblock zu vermeiden . Die venoese zerebrale Drainage muss gesichert werden , da eine beidseitige Ligatur des Sinus sigmoideus zur zerebralen venoesen Hypertension fuehren wuerde . Am Beispiel eines grossen bilateralen Glomus-jugulare-Tumors der Klasse C2 ermoeglichte die superselektive Angiographie und Embolisation die beidseitige vollstaendige Tumorentfernung ohne Funktionseinschraenkungen ueber einen transmastoidalen-transzervikalen Zugang . Durch temporaere Ventralverlagerung der hinteren Gehoergangswand gelang auch die Erhaltung der Mittelohrfunktion . Wegen der Ligatur der V. jugularis interna und des Sinus sigmoideus auf der 1. Seite konnte die 2. Seite erst 1 Jahr spaeter operiert werden , nachdem die Angiographie und Kompression der verbliebenen V. jugularis interna ausreichende venoese Kollateralen bestaetigt hatte .
[ "Beidseitige", "Glomus", "-", "jugulare", "-", "Tumoren", "stellen", "eine", "Raritaet", "dar", ".", "Neben", "der", "Funktion", "des", "N.", "facialis", "muss", "bei", "ihrer", "Entfernung", "auch", "die", "Funktion", "der", "kaudalen", "Hirnnerven", "beruecksichtigt", "werden", ".", "Die", "Funktionserhaltung", "des", "Mittelohrs", "ist", "ebenfalls", "anzustreben", ",", "um", "einen", "beidseitigen", "Schalleitungsblock", "zu", "vermeiden", ".", "Die", "venoese", "zerebrale", "Drainage", "muss", "gesichert", "werden", ",", "da", "eine", "beidseitige", "Ligatur", "des", "Sinus", "sigmoideus", "zur", "zerebralen", "venoesen", "Hypertension", "fuehren", "wuerde", ".", "Am", "Beispiel", "eines", "grossen", "bilateralen", "Glomus", "-", "jugulare", "-", "Tumors", "der", "Klasse", "C2", "ermoeglichte", "die", "superselektive", "Angiographie", "und", "Embolisation", "die", "beidseitige", "vollstaendige", "Tumorentfernung", "ohne", "Funktionseinschraenkungen", "ueber", "einen", "transmastoidalen", "-", "transzervikalen", "Zugang", ".", "Durch", "temporaere", "Ventralverlagerung", "der", "hinteren", "Gehoergangswand", "gelang", "auch", "die", "Erhaltung", "der", "Mittelohrfunktion", ".", "Wegen", "der", "Ligatur", "der", "V.", "jugularis", "interna", "und", "des", "Sinus", "sigmoideus", "auf", "der", "1", ".", "Seite", "konnte", "die", "2", ".", "Seite", "erst", "1", "Jahr", "spaeter", "operiert", "werden", ",", "nachdem", "die", "Angiographie", "und", "Kompression", "der", "verbliebenen", "V.", "jugularis", "interna", "ausreichende", "venoese", "Kollateralen", "bestaetigt", "hatte", "." ]
[ "umlsterm" ]
tricyclic antidepressants is an umlsterm, anticoagulation is an umlsterm, Phenprocoumon is an umlsterm, anticoagulant is an umlsterm, Germany is an umlsterm, clinical trials is an umlsterm, drug - drug interaction is an umlsterm, phenprocoumon is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr_task0
Sentence: A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated .
[ "A", "potential", "impact", "of", "tricyclic", "antidepressants", "on", "oral", "anticoagulation", "is", "controversial", ".", "Phenprocoumon", "-", "the", "most", "commonly", "used", "anticoagulant", "in", "Germany", "-", "is", "rarely", "considered", "in", "clinical", "trials", ".", "In", "the", "present", "study", ",", "a", "potential", "drug", "-", "drug", "interaction", "between", "phenprocoumon", "and", "tricyclics", ",", "causing", "an", "alteration", "in", "prothrombinemic", "effects", ",", "has", "been", "investigated", "." ]
[ "umlsterm" ]
tricyclic antidepressants is an umlsterm, anticoagulation is an umlsterm, Phenprocoumon is an umlsterm, anticoagulant is an umlsterm, Germany is an umlsterm, clinical trials is an umlsterm, drug - drug interaction is an umlsterm, phenprocoumon is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr_task1
Sentence: A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated . Instructions: please typing these entity words according to sentence: tricyclic antidepressants, anticoagulation, Phenprocoumon, anticoagulant, Germany, clinical trials, drug - drug interaction, phenprocoumon Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated .
[ "A", "potential", "impact", "of", "tricyclic", "antidepressants", "on", "oral", "anticoagulation", "is", "controversial", ".", "Phenprocoumon", "-", "the", "most", "commonly", "used", "anticoagulant", "in", "Germany", "-", "is", "rarely", "considered", "in", "clinical", "trials", ".", "In", "the", "present", "study", ",", "a", "potential", "drug", "-", "drug", "interaction", "between", "phenprocoumon", "and", "tricyclics", ",", "causing", "an", "alteration", "in", "prothrombinemic", "effects", ",", "has", "been", "investigated", "." ]
[ "umlsterm" ]
tricyclic antidepressants, anticoagulation, Phenprocoumon, anticoagulant, Germany, clinical trials, drug - drug interaction, phenprocoumon
ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr_task2
Sentence: A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated .
[ "A", "potential", "impact", "of", "tricyclic", "antidepressants", "on", "oral", "anticoagulation", "is", "controversial", ".", "Phenprocoumon", "-", "the", "most", "commonly", "used", "anticoagulant", "in", "Germany", "-", "is", "rarely", "considered", "in", "clinical", "trials", ".", "In", "the", "present", "study", ",", "a", "potential", "drug", "-", "drug", "interaction", "between", "phenprocoumon", "and", "tricyclics", ",", "causing", "an", "alteration", "in", "prothrombinemic", "effects", ",", "has", "been", "investigated", "." ]
[ "umlsterm" ]
Gefaessprothesen is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Anaesthesieverfahren is an umlsterm, Risiken is an umlsterm, Patienten is an umlsterm, thorakalen Aorta is an umlsterm, Allgemeinanaesthesie is an umlsterm, Inzidenz is an umlsterm, Allgemeinanaesthesien is an umlsterm, Patienten is an umlsterm, Koerpertemperatur is an umlsterm, Anaesthesieverfahren is an umlsterm, Patienten is an umlsterm, Temperaturanstiege is an umlsterm, Komplikationen is an umlsterm, Stenokardie is an umlsterm, Myokardinfarkte is an umlsterm, Therapie is an umlsterm, Allgemeinanaesthesie is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm
DerAnaesthesist.60450931.ger.abstr_task0
Sentence: Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar .
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[ "umlsterm" ]
Gefaessprothesen is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Anaesthesieverfahren is an umlsterm, Risiken is an umlsterm, Patienten is an umlsterm, thorakalen Aorta is an umlsterm, Allgemeinanaesthesie is an umlsterm, Inzidenz is an umlsterm, Allgemeinanaesthesien is an umlsterm, Patienten is an umlsterm, Koerpertemperatur is an umlsterm, Anaesthesieverfahren is an umlsterm, Patienten is an umlsterm, Temperaturanstiege is an umlsterm, Komplikationen is an umlsterm, Stenokardie is an umlsterm, Myokardinfarkte is an umlsterm, Therapie is an umlsterm, Allgemeinanaesthesie is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm
DerAnaesthesist.60450931.ger.abstr_task1
Sentence: Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar . Instructions: please typing these entity words according to sentence: Gefaessprothesen, Methoden, Therapie, Anaesthesieverfahren, Risiken, Patienten, thorakalen Aorta, Allgemeinanaesthesie, Inzidenz, Allgemeinanaesthesien, Patienten, Koerpertemperatur, Anaesthesieverfahren, Patienten, Temperaturanstiege, Komplikationen, Stenokardie, Myokardinfarkte, Therapie, Allgemeinanaesthesie, Patienten, Risiko Options: umlsterm
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Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar .
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[ "umlsterm" ]
Gefaessprothesen, Methoden, Therapie, Anaesthesieverfahren, Risiken, Patienten, thorakalen Aorta, Allgemeinanaesthesie, Inzidenz, Allgemeinanaesthesien, Patienten, Koerpertemperatur, Anaesthesieverfahren, Patienten, Temperaturanstiege, Komplikationen, Stenokardie, Myokardinfarkte, Therapie, Allgemeinanaesthesie, Patienten, Risiko
DerAnaesthesist.60450931.ger.abstr_task2
Sentence: Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar . Instructions: please extract entity words from the input sentence
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Die transvaskulaere Plazierung endoluminaler Gefaessprothesen mittels interventionell-radiologischer Methoden ist ein neues , minimal invasives Verfahren zur Therapie von Aortenaneurysmen . Wir analysierten retrospektiv die Praktikabilitaet verschiedener Anaesthesieverfahren , die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken . Bei 19 Patienten mit Aneurysmen der infrarenalen ( n=18) oder der thorakalen Aorta ( n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert . Die Eingriffe erfolgten in Allgemeinanaesthesie ( AA : n=9), in Periduralanaesthesie ( PDA : n=8) oder Lokalanaesthesie ( LA : n=6) mit Analgosedierung . Trotz erhoehten Ueberwachungsaufwands in der Gruppe AA ergaben sich keine Unterschiede in folgenden Parametern : Inzidenz und Dauer intraoperativer hypertensiver , brady- oder tachykarder Phasen ; Einsatz von Vasopressoren , Antihypertensiva oder Volumenersatz . Hypotensive Episoden waren bei Allgemeinanaesthesien haeufiger . Postoperativ zeigten alle Patienten Anstiege der Koerpertemperatur sowie laborchemischer Entzuendungsparameter . Vom Anaesthesieverfahren abhaengige Unterschiede im Verlauf der Entzuendungsreaktion waren nicht erkennbar . 13 von 18 Patienten zeigten passagere arterielle Desaturationen zwischen 83% und 95% . In 3 Faellen gingen Temperaturanstiege mit kardialen Komplikationen ( Tachyarrhythmien Stenokardie ) , einher . Perioperative Myokardinfarkte oder Todesfaelle traten nicht auf . Zur endovaskulaeren Therapie ausgewaehlter Aortenaneurysmen sind neben der Allgemeinanaesthesie auch die Regional- oder die Lokalanaesthesie mit Analgosedierung praktikable sichere Verfahren , , sofern invasives Monitoring und engmaschige postoperative Ueberwachung gewaehrleistet sind . Die eingriffstypische abakterielle Entzuendungsreaktion stellt fuer kardiopulmonal vorgeschaedigte Patienten ein Risiko dar .
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[ "umlsterm" ]
learning conversation is a Intervention_Educational, sandwich technique is a Intervention_Educational, Six - hundred and forty is a Participant_Sample-size, teaching using either the sandwich technique or the learning conversation . is a Intervention_Educational, Fifty - eight is a Participant_Sample-size, learning conversation or sandwich technique is a Intervention_Educational, skill acquisition as measured by an end - of - course competency assessment is a Outcome_Mental, instructors ' perception of teaching with each feedback technique is a Outcome_Mental, candidates ' perception of the feedback they were provided with is a Outcome_Mental, instructor perception of the feedback technique is a Outcome_Other, assessment pass rates is a Outcome_Other
72419_task0
Sentence: Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Educational, Outcome_Mental, Participant_Sample-size
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Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition .
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[ "Intervention_Educational", "Outcome_Mental", "Outcome_Other", "Participant_Sample-size" ]
learning conversation is a Intervention_Educational, sandwich technique is a Intervention_Educational, Six - hundred and forty is a Participant_Sample-size, teaching using either the sandwich technique or the learning conversation . is a Intervention_Educational, Fifty - eight is a Participant_Sample-size, learning conversation or sandwich technique is a Intervention_Educational, skill acquisition as measured by an end - of - course competency assessment is a Outcome_Mental, instructors ' perception of teaching with each feedback technique is a Outcome_Mental, candidates ' perception of the feedback they were provided with is a Outcome_Mental, instructor perception of the feedback technique is a Outcome_Other, assessment pass rates is a Outcome_Other
72419_task1
Sentence: Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition . Instructions: please typing these entity words according to sentence: learning conversation, sandwich technique, Six - hundred and forty, teaching using either the sandwich technique or the learning conversation ., Fifty - eight, learning conversation or sandwich technique, skill acquisition as measured by an end - of - course competency assessment, instructors ' perception of teaching with each feedback technique, candidates ' perception of the feedback they were provided with, instructor perception of the feedback technique, assessment pass rates Options: Outcome_Other, Intervention_Educational, Outcome_Mental, Participant_Sample-size
[ "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition .
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[ "Intervention_Educational", "Outcome_Mental", "Outcome_Other", "Participant_Sample-size" ]
learning conversation, sandwich technique, Six - hundred and forty, teaching using either the sandwich technique or the learning conversation ., Fifty - eight, learning conversation or sandwich technique, skill acquisition as measured by an end - of - course competency assessment, instructors ' perception of teaching with each feedback technique, candidates ' perception of the feedback they were provided with, instructor perception of the feedback technique, assessment pass rates
72419_task2
Sentence: Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition . Instructions: please extract entity words from the input sentence
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Use of the learning conversation improves instructor confidence in life support training : An open randomised controlled cross-over trial comparing teaching feedback mechanisms . AIMS Feedback is vital for the effective delivery of skills-based education . We sought to compare the sandwich technique and learning conversation structured methods of feedback delivery in competency-based basic life support ( BLS ) training . METHODS Open randomised crossover study undertaken between October 2014 and March 2015 at the University of Birmingham , United Kingdom . Six-hundred and forty healthcare students undertaking a European Resuscitation Council ( ERC ) BLS course were enrolled , each of whom was randomised to receive teaching using either the sandwich technique or the learning conversation . Fifty-eight instructors were randomised to initially teach using either the learning conversation or sandwich technique , prior to crossing-over and teaching with the alternative technique after a pre-defined time period . Outcome measures included skill acquisition as measured by an end-of-course competency assessment , instructors ' perception of teaching with each feedback technique and candidates ' perception of the feedback they were provided with . RESULTS Scores assigned to use of the learning conversation by instructors were significantly more favourable than for the sandwich technique across all but two assessed domains relating to instructor perception of the feedback technique , including all skills-based domains . No difference was seen in either assessment pass rates ( 80.9 % sandwich technique vs. 77.2 % learning conversation ; OR 1.2 , 95 % CI 0.85-1.84 ; p=0.29 ) or any domain relating to candidates ' perception of their teaching technique . CONCLUSIONS & RELEVANCE This is the first direct comparison of two feedback techniques in clinical medical education using both quantitative and qualitative methodology . The learning conversation is preferred by instructors providing competency-based life support training and is perceived to favour skills acquisition .
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[ "Intervention_Educational", "Outcome_Mental", "Outcome_Other", "Participant_Sample-size" ]
in vivo footprinted DNA motifs is a DNA_family_or_group, alpha - globin enhancer is a DNA_domain_or_region, Erythroid lineage is an other_name
3229_task0
Sentence: Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, DNA_domain_or_region, other_name
[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "O" ]
Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities.
[ "Functional", "roles", "of", "in", "vivo", "footprinted", "DNA", "motifs", "within", "an", "alpha", "-", "globin", "enhancer", ".", "Erythroid", "lineage", "and", "developmental", "stage", "specificities", "." ]
[ "(AND other_name other_name)", "DNA_domain_or_region", "cell_line", "other_name", "protein_molecule", "DNA_family_or_group", "protein_family_or_group", "" ]
in vivo footprinted DNA motifs is a DNA_family_or_group, alpha - globin enhancer is a DNA_domain_or_region, Erythroid lineage is an other_name
3229_task1
Sentence: Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities. Instructions: please typing these entity words according to sentence: in vivo footprinted DNA motifs, alpha - globin enhancer, Erythroid lineage Options: DNA_family_or_group, DNA_domain_or_region, other_name
[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "O" ]
Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities.
[ "Functional", "roles", "of", "in", "vivo", "footprinted", "DNA", "motifs", "within", "an", "alpha", "-", "globin", "enhancer", ".", "Erythroid", "lineage", "and", "developmental", "stage", "specificities", "." ]
[ "(AND other_name other_name)", "DNA_domain_or_region", "cell_line", "other_name", "protein_molecule", "DNA_family_or_group", "protein_family_or_group", "" ]
in vivo footprinted DNA motifs, alpha - globin enhancer, Erythroid lineage
3229_task2
Sentence: Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "O" ]
Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer. Erythroid lineage and developmental stage specificities.
[ "Functional", "roles", "of", "in", "vivo", "footprinted", "DNA", "motifs", "within", "an", "alpha", "-", "globin", "enhancer", ".", "Erythroid", "lineage", "and", "developmental", "stage", "specificities", "." ]
[ "(AND other_name other_name)", "DNA_domain_or_region", "cell_line", "other_name", "protein_molecule", "DNA_family_or_group", "protein_family_or_group", "" ]