bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
gestational age, > = 28 weeks, Systolic blood pressure, > = 160 mm Hg, diastolic blood pressure, > = 110 mm Hg, > = 18, years	NCT01912677_inc_task2	Sentence: Pregnant gestational age >= 28 weeks Systolic blood pressure >=160 mm Hg OR a diastolic blood pressure of >=110 mm Hg measured twice more than 15 minutes apart Able to swallow pills >= 18 years Instructions: please extract entity words from the input sentence	[ "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O" ]	Pregnant gestational age >= 28 weeks Systolic blood pressure >=160 mm Hg OR a diastolic blood pressure of >=110 mm Hg measured twice more than 15 minutes apart Able to swallow pills >= 18 years	[ "Pregnant", "gestational", "age", ">", "=", "28", "weeks", "\n", "Systolic", "blood", "pressure", ">", "=", "160", "mm", "Hg", "OR", "a", "diastolic", "blood", "pressure", "of", ">", "=", "110", "mm", "Hg", "measured", "twice", "more", "than", "15", "minutes", "apart", "\n", "Able", "to", "swallow", "pills", "\n", ">", "=", "18", "years", "\n" ]	[ "Measurement", "Value", "Person" ]
at least 18yrs is a Value, age is a Person, histologically is a Procedure, confirmed is a Value, CLL / SLL or B - cell Non - Hodgkin lymphoma is a Scope, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma is a Scope, Histological is a Procedure, FL is a Condition, Grade is a Measurement, 1 - 3A is a Value, iNHL is a Condition, relapsed or refractory disease is a Scope, iNHL is a Condition, LPL / WM , MZL is a Scope, aNHL is a Condition, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease is a Scope, CLL is a Condition, SLL is a Condition, PTCL is a Condition, CTCL is a Condition, MF / SS is a Scope, BCR and / or BCL2 inhibitors is a Scope, intolerant is a Condition, relapsed / refractory disease is a Scope, afterwards is a Temporal, Prior is a Temporal, treatment is a Procedure, lymphoid malignancy is a Condition, progressive is a Condition, ≥ 1 prior regimen is a Multiplier, min 2 cycles is a Multiplier, antibody conjugate , cytotoxic chemotherapy , or TKI is a Scope, Measureable disease is a Condition, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0 is a Scope, ECOG Score is a Measurement, 0 or 1 is a Value, Hematologic ANC is a Measurement, > 1000 / uL is a Value, platelet is a Measurement, > 75,000 / uL is a Value, Serum creatinine is a Measurement, < 1.5 ULN is a Value, calculated CrCl is a Measurement, > 50 mL / min is a Value, Bilirubin is a Measurement, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ) is a Scope, AST / AST is a Measurement, < 2.5 ULN is a Value	NCT01994382_inc_task0	Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Multiplier, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Procedure", "B-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "O", "B-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "O", "O", "B-Temporal", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN	[ "Phase", "1", "Specific", "Patient", "at", "least", "18yrs", "of", "age", "with", "histologically", "confirmed", "CLL", "/", "SLL", "or", "B", "-", "cell", "Non", "-", "Hodgkin", "lymphoma", "(", "DLBCL", ",", "FL", ",", "MCL", ",", "MZL", ",", "lymphoplasmacytic", "lymphoma", ")", ".", "\n", "Phase", "2a", "Inclusion", "\n", "Histological", "evidence", ":", "FL", "Grade", "1", "-", "3A", "/", "iNHL", ",", "with", "relapsed", "or", "refractory", "disease", "(", "iNHL", "includes", "LPL", "/", "WM", ",", "MZL", ")", ";", "aNHL", ",", "defined", "as", "DLBCL", ",", "FL", "Grade", "3B", ",", "MCL", ",", "and", "transformed", "NHL", "with", "relapsed", "disease", ";", "CLL", "/", "SLL", ",", "PTCL", ",", "or", "CTCL", "(", "with", "MF", "/", "SS", ")", "with", "relapsed", "or", "refractory", ".", "\n", "Received", "BCR", "and", "/", "or", "BCL2", "inhibitors", "were", "intolerant", "or", "had", "relapsed", "/", "refractory", "disease", "afterwards", ".", "\n", "Prior", "treatment", "for", "lymphoid", "malignancy", "for", "progressive", "/refractory", "disease", "\n", "≥", "1", "prior", "regimen", "(", "min", "2", "cycles", ")", "with", "antibody", "conjugate", ",", "cytotoxic", "chemotherapy", ",", "or", "TKI", "alone", "or", "in", "combination", ".", "\n", "Measureable", "disease", "defined", "as", ":", "≥", "1", "lesion", "≥", "1.5", "cm", "single", "dimension", "via", "CT", ",", "CT", "/", "PET", "with", "nodal", "or", "mass", "lesions", ";", "Quantifiable", "circulating", "tumor", "cells", ";", "or", "for", "Waldenström", "'s", "macroglobulinemia", "presence", "of", "IgM", "l", ">", "2X", "ULN", ";", "For", "CTCL", ":", "mSWAT", ">", "0", "\n", "Ability", "to", "provide", "diagnostic", "reports", "\n", "General", "Inclusion", "\n", "ECOG", "Score", "of", "0", "or", "1", ".", "\n", "Hematologic", "ANC", ">", "1000", "/", "uL", "and", "platelet", ">", "75,000", "/", "uL", ",", "\n", "Serum", "creatinine", "of", "<", "1.5", "ULN", "or", "calculated", "CrCl", "of", ">", "50", "mL", "/", "min", "\n", "Bilirubin", "<", "20.0mg", "/", "dL", "(", "if", "Gilberts", "then", "<", "2.5", "mg", "/", "dL", ")", "and", "AST", "/", "AST", "<", "2.5", "ULN", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]
at least 18yrs is a Value, age is a Person, histologically is a Procedure, confirmed is a Value, CLL / SLL or B - cell Non - Hodgkin lymphoma is a Scope, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma is a Scope, Histological is a Procedure, FL is a Condition, Grade is a Measurement, 1 - 3A is a Value, iNHL is a Condition, relapsed or refractory disease is a Scope, iNHL is a Condition, LPL / WM , MZL is a Scope, aNHL is a Condition, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease is a Scope, CLL is a Condition, SLL is a Condition, PTCL is a Condition, CTCL is a Condition, MF / SS is a Scope, BCR and / or BCL2 inhibitors is a Scope, intolerant is a Condition, relapsed / refractory disease is a Scope, afterwards is a Temporal, Prior is a Temporal, treatment is a Procedure, lymphoid malignancy is a Condition, progressive is a Condition, ≥ 1 prior regimen is a Multiplier, min 2 cycles is a Multiplier, antibody conjugate , cytotoxic chemotherapy , or TKI is a Scope, Measureable disease is a Condition, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0 is a Scope, ECOG Score is a Measurement, 0 or 1 is a Value, Hematologic ANC is a Measurement, > 1000 / uL is a Value, platelet is a Measurement, > 75,000 / uL is a Value, Serum creatinine is a Measurement, < 1.5 ULN is a Value, calculated CrCl is a Measurement, > 50 mL / min is a Value, Bilirubin is a Measurement, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ) is a Scope, AST / AST is a Measurement, < 2.5 ULN is a Value	NCT01994382_inc_task1	Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please typing these entity words according to sentence: at least 18yrs, age, histologically, confirmed, CLL / SLL or B - cell Non - Hodgkin lymphoma, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma, Histological, FL, Grade, 1 - 3A, iNHL, relapsed or refractory disease, iNHL, LPL / WM , MZL, aNHL, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease, CLL, SLL, PTCL, CTCL, MF / SS, BCR and / or BCL2 inhibitors, intolerant, relapsed / refractory disease, afterwards, Prior, treatment, lymphoid malignancy, progressive, ≥ 1 prior regimen, min 2 cycles, antibody conjugate , cytotoxic chemotherapy , or TKI, Measureable disease, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0, ECOG Score, 0 or 1, Hematologic ANC, > 1000 / uL, platelet, > 75,000 / uL, Serum creatinine, < 1.5 ULN, calculated CrCl, > 50 mL / min, Bilirubin, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ), AST / AST, < 2.5 ULN Options: Temporal, Condition, Value, Person, Multiplier, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Procedure", "B-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "O", "B-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "O", "O", "B-Temporal", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN	[ "Phase", "1", "Specific", "Patient", "at", "least", "18yrs", "of", "age", "with", "histologically", "confirmed", "CLL", "/", "SLL", "or", "B", "-", "cell", "Non", "-", "Hodgkin", "lymphoma", "(", "DLBCL", ",", "FL", ",", "MCL", ",", "MZL", ",", "lymphoplasmacytic", "lymphoma", ")", ".", "\n", "Phase", "2a", "Inclusion", "\n", "Histological", "evidence", ":", "FL", "Grade", "1", "-", "3A", "/", "iNHL", ",", "with", "relapsed", "or", "refractory", "disease", "(", "iNHL", "includes", "LPL", "/", "WM", ",", "MZL", ")", ";", "aNHL", ",", "defined", "as", "DLBCL", ",", "FL", "Grade", "3B", ",", "MCL", ",", "and", "transformed", "NHL", "with", "relapsed", "disease", ";", "CLL", "/", "SLL", ",", "PTCL", ",", "or", "CTCL", "(", "with", "MF", "/", "SS", ")", "with", "relapsed", "or", "refractory", ".", "\n", "Received", "BCR", "and", "/", "or", "BCL2", "inhibitors", "were", "intolerant", "or", "had", "relapsed", "/", "refractory", "disease", "afterwards", ".", "\n", "Prior", "treatment", "for", "lymphoid", "malignancy", "for", "progressive", "/refractory", "disease", "\n", "≥", "1", "prior", "regimen", "(", "min", "2", "cycles", ")", "with", "antibody", "conjugate", ",", "cytotoxic", "chemotherapy", ",", "or", "TKI", "alone", "or", "in", "combination", ".", "\n", "Measureable", "disease", "defined", "as", ":", "≥", "1", "lesion", "≥", "1.5", "cm", "single", "dimension", "via", "CT", ",", "CT", "/", "PET", "with", "nodal", "or", "mass", "lesions", ";", "Quantifiable", "circulating", "tumor", "cells", ";", "or", "for", "Waldenström", "'s", "macroglobulinemia", "presence", "of", "IgM", "l", ">", "2X", "ULN", ";", "For", "CTCL", ":", "mSWAT", ">", "0", "\n", "Ability", "to", "provide", "diagnostic", "reports", "\n", "General", "Inclusion", "\n", "ECOG", "Score", "of", "0", "or", "1", ".", "\n", "Hematologic", "ANC", ">", "1000", "/", "uL", "and", "platelet", ">", "75,000", "/", "uL", ",", "\n", "Serum", "creatinine", "of", "<", "1.5", "ULN", "or", "calculated", "CrCl", "of", ">", "50", "mL", "/", "min", "\n", "Bilirubin", "<", "20.0mg", "/", "dL", "(", "if", "Gilberts", "then", "<", "2.5", "mg", "/", "dL", ")", "and", "AST", "/", "AST", "<", "2.5", "ULN", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]
at least 18yrs, age, histologically, confirmed, CLL / SLL or B - cell Non - Hodgkin lymphoma, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma, Histological, FL, Grade, 1 - 3A, iNHL, relapsed or refractory disease, iNHL, LPL / WM , MZL, aNHL, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease, CLL, SLL, PTCL, CTCL, MF / SS, BCR and / or BCL2 inhibitors, intolerant, relapsed / refractory disease, afterwards, Prior, treatment, lymphoid malignancy, progressive, ≥ 1 prior regimen, min 2 cycles, antibody conjugate , cytotoxic chemotherapy , or TKI, Measureable disease, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0, ECOG Score, 0 or 1, Hematologic ANC, > 1000 / uL, platelet, > 75,000 / uL, Serum creatinine, < 1.5 ULN, calculated CrCl, > 50 mL / min, Bilirubin, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ), AST / AST, < 2.5 ULN	NCT01994382_inc_task2	Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Procedure", "B-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "O", "B-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "O", "O", "B-Temporal", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN	[ "Phase", "1", "Specific", "Patient", "at", "least", "18yrs", "of", "age", "with", "histologically", "confirmed", "CLL", "/", "SLL", "or", "B", "-", "cell", "Non", "-", "Hodgkin", "lymphoma", "(", "DLBCL", ",", "FL", ",", "MCL", ",", "MZL", ",", "lymphoplasmacytic", "lymphoma", ")", ".", "\n", "Phase", "2a", "Inclusion", "\n", "Histological", "evidence", ":", "FL", "Grade", "1", "-", "3A", "/", "iNHL", ",", "with", "relapsed", "or", "refractory", "disease", "(", "iNHL", "includes", "LPL", "/", "WM", ",", "MZL", ")", ";", "aNHL", ",", "defined", "as", "DLBCL", ",", "FL", "Grade", "3B", ",", "MCL", ",", "and", "transformed", "NHL", "with", "relapsed", "disease", ";", "CLL", "/", "SLL", ",", "PTCL", ",", "or", "CTCL", "(", "with", "MF", "/", "SS", ")", "with", "relapsed", "or", "refractory", ".", "\n", "Received", "BCR", "and", "/", "or", "BCL2", "inhibitors", "were", "intolerant", "or", "had", "relapsed", "/", "refractory", "disease", "afterwards", ".", "\n", "Prior", "treatment", "for", "lymphoid", "malignancy", "for", "progressive", "/refractory", "disease", "\n", "≥", "1", "prior", "regimen", "(", "min", "2", "cycles", ")", "with", "antibody", "conjugate", ",", "cytotoxic", "chemotherapy", ",", "or", "TKI", "alone", "or", "in", "combination", ".", "\n", "Measureable", "disease", "defined", "as", ":", "≥", "1", "lesion", "≥", "1.5", "cm", "single", "dimension", "via", "CT", ",", "CT", "/", "PET", "with", "nodal", "or", "mass", "lesions", ";", "Quantifiable", "circulating", "tumor", "cells", ";", "or", "for", "Waldenström", "'s", "macroglobulinemia", "presence", "of", "IgM", "l", ">", "2X", "ULN", ";", "For", "CTCL", ":", "mSWAT", ">", "0", "\n", "Ability", "to", "provide", "diagnostic", "reports", "\n", "General", "Inclusion", "\n", "ECOG", "Score", "of", "0", "or", "1", ".", "\n", "Hematologic", "ANC", ">", "1000", "/", "uL", "and", "platelet", ">", "75,000", "/", "uL", ",", "\n", "Serum", "creatinine", "of", "<", "1.5", "ULN", "or", "calculated", "CrCl", "of", ">", "50", "mL", "/", "min", "\n", "Bilirubin", "<", "20.0mg", "/", "dL", "(", "if", "Gilberts", "then", "<", "2.5", "mg", "/", "dL", ")", "and", "AST", "/", "AST", "<", "2.5", "ULN", "\n" ]	[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]
Surgical is an umlsterm, metastases is an umlsterm, overall is an umlsterm, survival is an umlsterm, carcinoma is an umlsterm, patients is an umlsterm, survival is an umlsterm, breast is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, lung cancer is an umlsterm, metastases is an umlsterm, breast is an umlsterm, renal cell carcinoma is an umlsterm, Age is an umlsterm, patients is an umlsterm, survival is an umlsterm, surgery is an umlsterm, morbidity is an umlsterm, hospitalization is an umlsterm, time is an umlsterm, patients is an umlsterm, survival is an umlsterm	DerOrthopaede.80270294.eng.abstr_task0	Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .	[ "Surgical", "resection", "of", "osseous", "metastases", "is", "becoming", "more", "and", "more", "important", "in", "obtaining", "longer", "overall", "survival", "in", "carcinoma", "patients", ".", "In", "228", "cases", "surgically", "treated", "at", "our", "institution", "between", "1980", "and", "1993", ",", "the", "survival", "was", "49", "%", "after", "1", "year", ",", "32", "%", "after", "2", "years", ",", "22", "%", "after", "3", "years", "and", ",", "finally", ",", "11", "%", "after", "5", "years", ".", "Retrospectively", "evaluated", ",", "breast", "and", "thyroid", "carcinoma", "proved", "to", "be", "of", "positive", "prognostic", "influence", "and", "lung", "cancer", "of", "negative", "significance", ".", "As", "a", "main", "significant", "parameter", ",", "further", "extraosseous", "metastases", "were", "evaluated", ".", "The", "prognostic", "influence", "of", "the", "number", "of", "osseous", "lesions", "could", "only", "be", "demonstrated", "in", "breast", "and", "renal", "cell", "carcinoma", "without", "involvement", "of", "further", "organs", ".", "Age", "and", "location", "of", "the", "skeletal", "lesions", "proved", "to", "be", "of", "no", "prognostic", "influence", ".", "Based", "on", "these", "prognostic", "parameters", ",", "three", "subgroups", "of", "patients", "with", "worse", ",", "median", "and", "good", "long", "-", "term", "survival", "could", "be", "defined", ".", "In", "conclusion", ",", "the", "indication", "and", "amount", "of", "surgery", "can", "be", "based", "on", "these", "prognostic", "factors", ",", "leading", "to", "a", "decrease", "in", "morbidity", "and", "hospitalization", "time", "in", "patients", "with", "limited", "survival", "." ]	[ "umlsterm" ]
Surgical is an umlsterm, metastases is an umlsterm, overall is an umlsterm, survival is an umlsterm, carcinoma is an umlsterm, patients is an umlsterm, survival is an umlsterm, breast is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, lung cancer is an umlsterm, metastases is an umlsterm, breast is an umlsterm, renal cell carcinoma is an umlsterm, Age is an umlsterm, patients is an umlsterm, survival is an umlsterm, surgery is an umlsterm, morbidity is an umlsterm, hospitalization is an umlsterm, time is an umlsterm, patients is an umlsterm, survival is an umlsterm	DerOrthopaede.80270294.eng.abstr_task1	Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please typing these entity words according to sentence: Surgical, metastases, overall, survival, carcinoma, patients, survival, breast, thyroid, carcinoma, lung cancer, metastases, breast, renal cell carcinoma, Age, patients, survival, surgery, morbidity, hospitalization, time, patients, survival Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .	[ "Surgical", "resection", "of", "osseous", "metastases", "is", "becoming", "more", "and", "more", "important", "in", "obtaining", "longer", "overall", "survival", "in", "carcinoma", "patients", ".", "In", "228", "cases", "surgically", "treated", "at", "our", "institution", "between", "1980", "and", "1993", ",", "the", "survival", "was", "49", "%", "after", "1", "year", ",", "32", "%", "after", "2", "years", ",", "22", "%", "after", "3", "years", "and", ",", "finally", ",", "11", "%", "after", "5", "years", ".", "Retrospectively", "evaluated", ",", "breast", "and", "thyroid", "carcinoma", "proved", "to", "be", "of", "positive", "prognostic", "influence", "and", "lung", "cancer", "of", "negative", "significance", ".", "As", "a", "main", "significant", "parameter", ",", "further", "extraosseous", "metastases", "were", "evaluated", ".", "The", "prognostic", "influence", "of", "the", "number", "of", "osseous", "lesions", "could", "only", "be", "demonstrated", "in", "breast", "and", "renal", "cell", "carcinoma", "without", "involvement", "of", "further", "organs", ".", "Age", "and", "location", "of", "the", "skeletal", "lesions", "proved", "to", "be", "of", "no", "prognostic", "influence", ".", "Based", "on", "these", "prognostic", "parameters", ",", "three", "subgroups", "of", "patients", "with", "worse", ",", "median", "and", "good", "long", "-", "term", "survival", "could", "be", "defined", ".", "In", "conclusion", ",", "the", "indication", "and", "amount", "of", "surgery", "can", "be", "based", "on", "these", "prognostic", "factors", ",", "leading", "to", "a", "decrease", "in", "morbidity", "and", "hospitalization", "time", "in", "patients", "with", "limited", "survival", "." ]	[ "umlsterm" ]
Surgical, metastases, overall, survival, carcinoma, patients, survival, breast, thyroid, carcinoma, lung cancer, metastases, breast, renal cell carcinoma, Age, patients, survival, surgery, morbidity, hospitalization, time, patients, survival	DerOrthopaede.80270294.eng.abstr_task2	Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .	[ "Surgical", "resection", "of", "osseous", "metastases", "is", "becoming", "more", "and", "more", "important", "in", "obtaining", "longer", "overall", "survival", "in", "carcinoma", "patients", ".", "In", "228", "cases", "surgically", "treated", "at", "our", "institution", "between", "1980", "and", "1993", ",", "the", "survival", "was", "49", "%", "after", "1", "year", ",", "32", "%", "after", "2", "years", ",", "22", "%", "after", "3", "years", "and", ",", "finally", ",", "11", "%", "after", "5", "years", ".", "Retrospectively", "evaluated", ",", "breast", "and", "thyroid", "carcinoma", "proved", "to", "be", "of", "positive", "prognostic", "influence", "and", "lung", "cancer", "of", "negative", "significance", ".", "As", "a", "main", "significant", "parameter", ",", "further", "extraosseous", "metastases", "were", "evaluated", ".", "The", "prognostic", "influence", "of", "the", "number", "of", "osseous", "lesions", "could", "only", "be", "demonstrated", "in", "breast", "and", "renal", "cell", "carcinoma", "without", "involvement", "of", "further", "organs", ".", "Age", "and", "location", "of", "the", "skeletal", "lesions", "proved", "to", "be", "of", "no", "prognostic", "influence", ".", "Based", "on", "these", "prognostic", "parameters", ",", "three", "subgroups", "of", "patients", "with", "worse", ",", "median", "and", "good", "long", "-", "term", "survival", "could", "be", "defined", ".", "In", "conclusion", ",", "the", "indication", "and", "amount", "of", "surgery", "can", "be", "based", "on", "these", "prognostic", "factors", ",", "leading", "to", "a", "decrease", "in", "morbidity", "and", "hospitalization", "time", "in", "patients", "with", "limited", "survival", "." ]	[ "umlsterm" ]
Strahlentherapie is an umlsterm, Tumorbett is an umlsterm, Therapieregimes is an umlsterm, Lokalrezidivrate is an umlsterm, Therapieregimen is an umlsterm, Tumorkontrolle is an umlsterm, Leber- is an umlsterm, Peritonealmetastasen is an umlsterm, Zeit is an umlsterm	DerChirurg.00710682.ger.abstr_task0	Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .	[ "Zusammenfassung", ".", "Durch", "intraoperative", "Strahlentherapie", "(", "IORT", ")", "wird", "unter", "maximaler", "Schonung", "der", "umliegenden", "strahlensensiblen", "Organe", "die", "Strahlendosis", "im", "Tumorbett", "lokal", "erhoeht", ".", "Mit", "diesem", "Verfahren", "als", "Bestandteil", "eines", "multimodalen", "Therapieregimes", "konnten", "sowohl", "die", "Lokalrezidivrate", "als", "auch", "die", "Ueberlebensrate", "gegenueber", "konventionellen", "Therapieregimen", "beim", "fortgeschrittenen", "primaeren", "Rectumcarcinom", "und", "Carcinomrezidiv", "verbessert", "werden", ".", "Dagegen", "ist", "bisher", "nur", "in", "wenigen", "Studien", "ueber", "eine", "verbesserte", "Ueberlebensrate", "durch", "zusaetzliche", "IORT", "beim", "fortgeschrittenen", "Magencarcinom", "berichtet", "worden", ".", "Beim", "Pankreascarcinom", "wird", "durch", "IORT", "die", "lokale", "Tumorkontrolle", ",", "nicht", "aber", "die", "Ueberlebensrate", "verbessert", ",", "da", "haeufig", "Leber-", "und", "Peritonealmetastasen", "auftreten", ".", "Fuer", "das", "Oesophaguscarcinom", "liegen", "zur", "Zeit", "nur", "unzureichende", "Daten", "vor", "." ]	[ "umlsterm" ]
Strahlentherapie is an umlsterm, Tumorbett is an umlsterm, Therapieregimes is an umlsterm, Lokalrezidivrate is an umlsterm, Therapieregimen is an umlsterm, Tumorkontrolle is an umlsterm, Leber- is an umlsterm, Peritonealmetastasen is an umlsterm, Zeit is an umlsterm	DerChirurg.00710682.ger.abstr_task1	Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please typing these entity words according to sentence: Strahlentherapie, Tumorbett, Therapieregimes, Lokalrezidivrate, Therapieregimen, Tumorkontrolle, Leber-, Peritonealmetastasen, Zeit Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .	[ "Zusammenfassung", ".", "Durch", "intraoperative", "Strahlentherapie", "(", "IORT", ")", "wird", "unter", "maximaler", "Schonung", "der", "umliegenden", "strahlensensiblen", "Organe", "die", "Strahlendosis", "im", "Tumorbett", "lokal", "erhoeht", ".", "Mit", "diesem", "Verfahren", "als", "Bestandteil", "eines", "multimodalen", "Therapieregimes", "konnten", "sowohl", "die", "Lokalrezidivrate", "als", "auch", "die", "Ueberlebensrate", "gegenueber", "konventionellen", "Therapieregimen", "beim", "fortgeschrittenen", "primaeren", "Rectumcarcinom", "und", "Carcinomrezidiv", "verbessert", "werden", ".", "Dagegen", "ist", "bisher", "nur", "in", "wenigen", "Studien", "ueber", "eine", "verbesserte", "Ueberlebensrate", "durch", "zusaetzliche", "IORT", "beim", "fortgeschrittenen", "Magencarcinom", "berichtet", "worden", ".", "Beim", "Pankreascarcinom", "wird", "durch", "IORT", "die", "lokale", "Tumorkontrolle", ",", "nicht", "aber", "die", "Ueberlebensrate", "verbessert", ",", "da", "haeufig", "Leber-", "und", "Peritonealmetastasen", "auftreten", ".", "Fuer", "das", "Oesophaguscarcinom", "liegen", "zur", "Zeit", "nur", "unzureichende", "Daten", "vor", "." ]	[ "umlsterm" ]
Strahlentherapie, Tumorbett, Therapieregimes, Lokalrezidivrate, Therapieregimen, Tumorkontrolle, Leber-, Peritonealmetastasen, Zeit	DerChirurg.00710682.ger.abstr_task2	Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .	[ "Zusammenfassung", ".", "Durch", "intraoperative", "Strahlentherapie", "(", "IORT", ")", "wird", "unter", "maximaler", "Schonung", "der", "umliegenden", "strahlensensiblen", "Organe", "die", "Strahlendosis", "im", "Tumorbett", "lokal", "erhoeht", ".", "Mit", "diesem", "Verfahren", "als", "Bestandteil", "eines", "multimodalen", "Therapieregimes", "konnten", "sowohl", "die", "Lokalrezidivrate", "als", "auch", "die", "Ueberlebensrate", "gegenueber", "konventionellen", "Therapieregimen", "beim", "fortgeschrittenen", "primaeren", "Rectumcarcinom", "und", "Carcinomrezidiv", "verbessert", "werden", ".", "Dagegen", "ist", "bisher", "nur", "in", "wenigen", "Studien", "ueber", "eine", "verbesserte", "Ueberlebensrate", "durch", "zusaetzliche", "IORT", "beim", "fortgeschrittenen", "Magencarcinom", "berichtet", "worden", ".", "Beim", "Pankreascarcinom", "wird", "durch", "IORT", "die", "lokale", "Tumorkontrolle", ",", "nicht", "aber", "die", "Ueberlebensrate", "verbessert", ",", "da", "haeufig", "Leber-", "und", "Peritonealmetastasen", "auftreten", ".", "Fuer", "das", "Oesophaguscarcinom", "liegen", "zur", "Zeit", "nur", "unzureichende", "Daten", "vor", "." ]	[ "umlsterm" ]
interferon is a Intervention_Pharmacological, response is a Outcome_Physical, alpha - interferon is a Intervention_Pharmacological, anti - human immunodeficiency virus antibody status is a Outcome_Physical, chronic active hepatitis on liver biopsy is a Outcome_Physical, AST level is a Outcome_Physical, hepatitis B virus DNA level is a Outcome_Physical, acute hepatitis is a Outcome_Physical, acute icteric hepatitis is a Outcome_Physical, HBsAg is a Outcome_Physical, HBeAg is a Outcome_Physical	41158_task0	Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical	[ "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .	[ "Treatment", "of", "hepatitis", "B", "virus", "infection", "with", "interferon", ".", "Factors", "predicting", "response", "to", "interferon", ".", "Several", "randomised", "controlled", "trials", "have", "been", "undertaken", "to", "evaluate", "the", "efficacy", "of", "alpha", "-", "interferon", "in", "the", "therapy", "of", "chronic", "hepatitis", "B", ".", "In", "patients", "with", "HBe", "antigen", "-", "positive", "disease", "acquired", "in", "adult", "life", "the", "response", "rates", "vary", "from", "25", "-", "50", "%", ".", "In", "those", "infected", "at", "birth", ",", "response", "rates", "are", "lower", ".", "Twenty", "-", "one", "pretreatment", "variables", "were", "assessed", "for", "their", "significance", "in", "response", "prediction", "using", "data", "from", "114", "patients", "given", "alpha", "-", "interferon", "for", "chronic", "hepatitis", "B", "virus", "infection", ".", "In", "those", "patients", "who", "had", "received", "a", "minimum", "of", "90", "million", "units", "per", "m2", "total", "dose", "over", "12", "weeks", ",", "a", "negative", "anti", "-", "human", "immunodeficiency", "virus", "antibody", "status", "(", "p", "less", "than", "0.001", ")", ",", "chronic", "active", "hepatitis", "on", "liver", "biopsy", "(", "p", "less", "than", "0.005", ")", ",", "high", "AST", "level", "(", "p", "less", "than", "0.001", ")", ",", "low", "hepatitis", "B", "virus", "DNA", "level", "(", "p", "less", "than", "0.001", ")", "and", "a", "history", "of", "acute", "hepatitis", "(", "p", "less", "than", "0.005", ")", "were", "all", "associated", "with", "an", "increased", "likelihood", "of", "response", "on", "univariate", "analysis", ".", "On", "stepwise", "logistic", "regression", "analysis", ",", "hepatitis", "B", "virus", "DNA", ",", "AST", "and", "a", "history", "of", "acute", "hepatitis", "predicted", "response", "independently", "(", "p", "less", "than", "0.05", ")", ".", "The", "most", "reliable", "combination", "of", "predictive", "factors", "was", "a", "negative", "anti", "-", "human", "immunodeficiency", "virus", "antibody", "status", ",", "with", "either", "a", "positive", "history", "of", "acute", "icteric", "hepatitis", "and", "AST", "greater", "than", "45", "IU", "per", "liter", "or", "no", "history", "of", "acute", "icteric", "hepatitis", "and", "AST", "greater", "than", "85", "IU", "per", "liter", ",", "which", "predicted", "response", "in", "77", "%", "with", "a", "specificity", "of", "79", "%", "(", "p", "less", "than", "0.001", ")", ".", "The", "loss", "of", "HBsAg", "in", "addition", "to", "HBeAg", "and", "hepatitis", "B", "virus", "DNA", "was", "more", "likely", "to", "occur", "in", "patients", "with", "chronic", "infection", "of", "less", "than", "2", "years", "duration", "(", "p", "less", "than", "0.001", ")", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological" ]
interferon is a Intervention_Pharmacological, response is a Outcome_Physical, alpha - interferon is a Intervention_Pharmacological, anti - human immunodeficiency virus antibody status is a Outcome_Physical, chronic active hepatitis on liver biopsy is a Outcome_Physical, AST level is a Outcome_Physical, hepatitis B virus DNA level is a Outcome_Physical, acute hepatitis is a Outcome_Physical, acute icteric hepatitis is a Outcome_Physical, HBsAg is a Outcome_Physical, HBeAg is a Outcome_Physical	41158_task1	Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please typing these entity words according to sentence: interferon, response, alpha - interferon, anti - human immunodeficiency virus antibody status, chronic active hepatitis on liver biopsy, AST level, hepatitis B virus DNA level, acute hepatitis, acute icteric hepatitis, HBsAg, HBeAg Options: Intervention_Pharmacological, Outcome_Physical	[ "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .	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interferon, response, alpha - interferon, anti - human immunodeficiency virus antibody status, chronic active hepatitis on liver biopsy, AST level, hepatitis B virus DNA level, acute hepatitis, acute icteric hepatitis, HBsAg, HBeAg	41158_task2	Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .	[ "Treatment", "of", "hepatitis", "B", "virus", "infection", "with", "interferon", ".", "Factors", "predicting", "response", "to", "interferon", ".", "Several", "randomised", "controlled", "trials", "have", "been", "undertaken", "to", "evaluate", "the", "efficacy", "of", "alpha", "-", "interferon", "in", "the", "therapy", "of", "chronic", "hepatitis", "B", ".", "In", "patients", "with", "HBe", "antigen", "-", "positive", "disease", "acquired", "in", "adult", "life", "the", "response", "rates", "vary", "from", "25", "-", "50", "%", ".", "In", "those", "infected", "at", "birth", ",", "response", "rates", "are", "lower", ".", "Twenty", "-", "one", "pretreatment", "variables", "were", "assessed", "for", "their", "significance", "in", "response", "prediction", "using", "data", "from", "114", "patients", "given", "alpha", "-", "interferon", "for", "chronic", "hepatitis", "B", "virus", "infection", ".", "In", "those", "patients", "who", "had", "received", "a", "minimum", "of", "90", "million", "units", "per", "m2", "total", "dose", "over", "12", "weeks", ",", "a", "negative", "anti", "-", "human", "immunodeficiency", "virus", "antibody", "status", "(", "p", "less", "than", "0.001", ")", ",", "chronic", "active", "hepatitis", "on", "liver", "biopsy", "(", "p", "less", "than", "0.005", ")", ",", "high", "AST", "level", "(", "p", "less", "than", "0.001", ")", ",", "low", "hepatitis", "B", "virus", "DNA", "level", "(", "p", "less", "than", "0.001", ")", "and", "a", "history", "of", "acute", "hepatitis", "(", "p", "less", "than", "0.005", ")", "were", "all", "associated", "with", "an", "increased", "likelihood", "of", "response", "on", "univariate", "analysis", ".", "On", "stepwise", "logistic", "regression", "analysis", ",", "hepatitis", "B", "virus", "DNA", ",", "AST", "and", "a", "history", "of", "acute", "hepatitis", "predicted", "response", "independently", "(", "p", "less", "than", "0.05", ")", ".", "The", "most", "reliable", "combination", "of", "predictive", "factors", "was", "a", "negative", "anti", "-", "human", "immunodeficiency", "virus", "antibody", "status", ",", "with", "either", "a", "positive", "history", "of", "acute", "icteric", "hepatitis", "and", "AST", "greater", "than", "45", "IU", "per", "liter", "or", "no", "history", "of", "acute", "icteric", "hepatitis", "and", "AST", "greater", "than", "85", "IU", "per", "liter", ",", "which", "predicted", "response", "in", "77", "%", "with", "a", "specificity", "of", "79", "%", "(", "p", "less", "than", "0.001", ")", ".", "The", "loss", "of", "HBsAg", "in", "addition", "to", "HBeAg", "and", "hepatitis", "B", "virus", "DNA", "was", "more", "likely", "to", "occur", "in", "patients", "with", "chronic", "infection", "of", "less", "than", "2", "years", "duration", "(", "p", "less", "than", "0.001", ")", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological" ]
Cys 23-Ser 23 is a ProteinMutation	1658_task0	Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation	[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.	[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]	[ "ProteinMutation" ]
Cys 23-Ser 23 is a ProteinMutation	1658_task1	Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please typing these entity words according to sentence: Cys 23-Ser 23 Options: ProteinMutation	[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.	[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]	[ "ProteinMutation" ]
Cys 23-Ser 23	1658_task2	Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please extract entity words from the input sentence	[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.	[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]	[ "ProteinMutation" ]
Herpes simplex virus is an umlsterm, infections is an umlsterm, cause is an umlsterm, ulcerations is an umlsterm, infections is an umlsterm, HSV-1 is an umlsterm, HSV-2 is an umlsterm, infections is an umlsterm, blood donors is an umlsterm, hospital is an umlsterm, patients is an umlsterm, risk factors is an umlsterm, herpesvirus infections is an umlsterm, STD is an umlsterm, infectious diseases is an umlsterm, immunosuppression is an umlsterm, native is an umlsterm, antigens is an umlsterm, glycoproteins is an umlsterm, Western blot is an umlsterm	Bundesgesundheitsblatt.90420776.eng.abstr_task0	Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .	[ "Herpes", "simplex", "virus", "type", "1", "(", "HSV-1", ")", "and", "type", "2", "(", "HSV-2", ")", "are", "the", "most", "frequent", "infections", "cause", "of", "genital", "ulcerations", ".", "Although", "genital", "infections", "by", "HSV-1", "are", "increasing", "HSV-2", "is", "dominant", "in", "recurrent", "infections", ".", "This", "study", "was", "conducted", "on", "a", "panel", "of", "sera", "collected", "anonymously", "in", "1996", "and", "1997", "from", "blood", "donors", "(", "1979", "samples", ")", "and", "hospital", "patients", "(", "3079", "samples", ")", "without", "risk", "factors", "for", "herpesvirus", "infections", "such", "as", "STD", ",", "other", "infectious", "diseases", "and", "immunosuppression", ".", "Serum", "samples", "were", "tested", "with", "ELISAs", "using", "monoclonal", "antibody", "-", "selected", "native", "gG1", "and", "gG2", "as", "antigens", "and", "an", "immunoblot", "using", "type", "-", "specific", "recombinant", "glycoproteins", ".", "Equivocal", "results", "were", "confirmed", "with", "an", "in", "-", "house", "Western", "blot", "." ]	[ "umlsterm" ]
Herpes simplex virus is an umlsterm, infections is an umlsterm, cause is an umlsterm, ulcerations is an umlsterm, infections is an umlsterm, HSV-1 is an umlsterm, HSV-2 is an umlsterm, infections is an umlsterm, blood donors is an umlsterm, hospital is an umlsterm, patients is an umlsterm, risk factors is an umlsterm, herpesvirus infections is an umlsterm, STD is an umlsterm, infectious diseases is an umlsterm, immunosuppression is an umlsterm, native is an umlsterm, antigens is an umlsterm, glycoproteins is an umlsterm, Western blot is an umlsterm	Bundesgesundheitsblatt.90420776.eng.abstr_task1	Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please typing these entity words according to sentence: Herpes simplex virus, infections, cause, ulcerations, infections, HSV-1, HSV-2, infections, blood donors, hospital, patients, risk factors, herpesvirus infections, STD, infectious diseases, immunosuppression, native, antigens, glycoproteins, Western blot Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .	[ "Herpes", "simplex", "virus", "type", "1", "(", "HSV-1", ")", "and", "type", "2", "(", "HSV-2", ")", "are", "the", "most", "frequent", "infections", "cause", "of", "genital", "ulcerations", ".", "Although", "genital", "infections", "by", "HSV-1", "are", "increasing", "HSV-2", "is", "dominant", "in", "recurrent", "infections", ".", "This", "study", "was", "conducted", "on", "a", "panel", "of", "sera", "collected", "anonymously", "in", "1996", "and", "1997", "from", "blood", "donors", "(", "1979", "samples", ")", "and", "hospital", "patients", "(", "3079", "samples", ")", "without", "risk", "factors", "for", "herpesvirus", "infections", "such", "as", "STD", ",", "other", "infectious", "diseases", "and", "immunosuppression", ".", "Serum", "samples", "were", "tested", "with", "ELISAs", "using", "monoclonal", "antibody", "-", "selected", "native", "gG1", "and", "gG2", "as", "antigens", "and", "an", "immunoblot", "using", "type", "-", "specific", "recombinant", "glycoproteins", ".", "Equivocal", "results", "were", "confirmed", "with", "an", "in", "-", "house", "Western", "blot", "." ]	[ "umlsterm" ]
Herpes simplex virus, infections, cause, ulcerations, infections, HSV-1, HSV-2, infections, blood donors, hospital, patients, risk factors, herpesvirus infections, STD, infectious diseases, immunosuppression, native, antigens, glycoproteins, Western blot	Bundesgesundheitsblatt.90420776.eng.abstr_task2	Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .	[ "Herpes", "simplex", "virus", "type", "1", "(", "HSV-1", ")", "and", "type", "2", "(", "HSV-2", ")", "are", "the", "most", "frequent", "infections", "cause", "of", "genital", "ulcerations", ".", "Although", "genital", "infections", "by", "HSV-1", "are", "increasing", "HSV-2", "is", "dominant", "in", "recurrent", "infections", ".", "This", "study", "was", "conducted", "on", "a", "panel", "of", "sera", "collected", "anonymously", "in", "1996", "and", "1997", "from", "blood", "donors", "(", "1979", "samples", ")", "and", "hospital", "patients", "(", "3079", "samples", ")", "without", "risk", "factors", "for", "herpesvirus", "infections", "such", "as", "STD", ",", "other", "infectious", "diseases", "and", "immunosuppression", ".", "Serum", "samples", "were", "tested", "with", "ELISAs", "using", "monoclonal", "antibody", "-", "selected", "native", "gG1", "and", "gG2", "as", "antigens", "and", "an", "immunoblot", "using", "type", "-", "specific", "recombinant", "glycoproteins", ".", "Equivocal", "results", "were", "confirmed", "with", "an", "in", "-", "house", "Western", "blot", "." ]	[ "umlsterm" ]
p. E300X is a ProteinMutation	432_task0	Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]	Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.	[ "Focal", "dermal", "hypoplasia", "resulting", "from", "a", "new", "nonsense", "mutation", ",", "p.", "E300X", ",", "in", "the", "PORCN", "gene", "." ]	[ "DNAMutation", "ProteinMutation" ]
p. E300X is a ProteinMutation	432_task1	Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please typing these entity words according to sentence: p. E300X Options: ProteinMutation	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]	Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.	[ "Focal", "dermal", "hypoplasia", "resulting", "from", "a", "new", "nonsense", "mutation", ",", "p.", "E300X", ",", "in", "the", "PORCN", "gene", "." ]	[ "DNAMutation", "ProteinMutation" ]
p. E300X	432_task2	Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]	Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.	[ "Focal", "dermal", "hypoplasia", "resulting", "from", "a", "new", "nonsense", "mutation", ",", "p.", "E300X", ",", "in", "the", "PORCN", "gene", "." ]	[ "DNAMutation", "ProteinMutation" ]
fixation of fractures is an umlsterm, bones is an umlsterm, method is an umlsterm, fracture is an umlsterm, bone is an umlsterm, fracture is an umlsterm, children is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, femur is an umlsterm, technique is an umlsterm, intramedullary nailing is an umlsterm, humerus is an umlsterm, hospital is an umlsterm, immobilisation is an umlsterm, patients is an umlsterm, operation is an umlsterm, hospital is an umlsterm, patients is an umlsterm, fractures is an umlsterm, operation is an umlsterm, intramedullary nails is an umlsterm, time is an umlsterm, weight is an umlsterm, legs is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, movements is an umlsterm, operation is an umlsterm, technique is an umlsterm, risks is an umlsterm, trauma is an umlsterm, early mobilisation is an umlsterm, literature is an umlsterm, nails is an umlsterm, skin is an umlsterm	DerUnfallchirurg.01030002.eng.abstr_task0	Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .	[ "The", "internal", "fixation", "of", "fractures", "of", "shaft", "bones", "was", "spread", "out", "by", "a", "group", "of", "surgeons", "working", "together", "with", "Prevot", ".", "The", "principle", "of", "this", "method", "is", "a", "three", "point", "load", "carrying", "(", "entry", "point", ",", "height", "of", "fracture", "and", "cancellous", "bone", "of", "the", "metaphysis", "of", "the", "opposite", "fracture", "part", ")", ".", "From", "1996", "to", "1999", "86", "children", "with", "fractures", "of", "the", "humerus", ",", "the", "fore", "-", "arm", "and", "the", "femur", "were", "operated", "in", "the", "technique", "of", "intramedullary", "nailing", ".", "The", "fractures", "affected", "the", "humerus", "to", "3.5", "%", ",", "the", "fore", "-", "arm", "to", "65.1", "%", "and", "the", "femoral", "shaft", "to", "31.4", "%", ".", "The", "postoperativ", "duration", "of", "stay", "in", "hospital", "after", "internal", "fixation", "of", "the", "fore", "-", "arm", "in", "the", "proximal", "and", "middle", "third", "lasted", "7.2", "days", ",", "the", "duration", "of", "immobilisation", "in", "a", "cast", "took", "13.7", "days", ".", "96", "%", "of", "the", "patients", "showed", "very", "good", "and", "good", "results", "after", "operation", ".", "The", "average", "stay", "in", "hospital", "for", "patients", "with", "femoral", "shaft", "fractures", "was", "14.4", "days", ".", "17", "weeks", "after", "operation", "the", "intramedullary", "nails", "were", "removed", ".", "At", "the", "time", "of", "first", "full", "weight", "bearing", "the", "legs", "showed", "an", "average", "shortening", "of", "1.2", "cm", ".", "The", "fractures", "of", "the", "humerus", "healed", "without", "any", "restriction", "of", "movements", ".", "Internal", "fixation", "is", "a", "minimal", "invasive", "operation", "technique", "with", "low", "risks", "and", "small", "operating", "trauma", ".", "Due", "to", "the", "stability", "a", "early", "mobilisation", "is", "possible", ".", "The", "reported", "results", "in", "the", "literature", "are", "all", "good", ".", "The", "only", "problem", "can", "be", "caused", "by", "too", "long", "nails", "irritating", "the", "skin", "." ]	[ "umlsterm" ]
fixation of fractures is an umlsterm, bones is an umlsterm, method is an umlsterm, fracture is an umlsterm, bone is an umlsterm, fracture is an umlsterm, children is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, femur is an umlsterm, technique is an umlsterm, intramedullary nailing is an umlsterm, humerus is an umlsterm, hospital is an umlsterm, immobilisation is an umlsterm, patients is an umlsterm, operation is an umlsterm, hospital is an umlsterm, patients is an umlsterm, fractures is an umlsterm, operation is an umlsterm, intramedullary nails is an umlsterm, time is an umlsterm, weight is an umlsterm, legs is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, movements is an umlsterm, operation is an umlsterm, technique is an umlsterm, risks is an umlsterm, trauma is an umlsterm, early mobilisation is an umlsterm, literature is an umlsterm, nails is an umlsterm, skin is an umlsterm	DerUnfallchirurg.01030002.eng.abstr_task1	Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please typing these entity words according to sentence: fixation of fractures, bones, method, fracture, bone, fracture, children, fractures, humerus, femur, technique, intramedullary nailing, humerus, hospital, immobilisation, patients, operation, hospital, patients, fractures, operation, intramedullary nails, time, weight, legs, fractures, humerus, movements, operation, technique, risks, trauma, early mobilisation, literature, nails, skin Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .	[ "The", "internal", "fixation", "of", "fractures", "of", "shaft", "bones", "was", "spread", "out", "by", "a", "group", "of", "surgeons", "working", "together", "with", "Prevot", ".", "The", "principle", "of", "this", "method", "is", "a", "three", "point", "load", "carrying", "(", "entry", "point", ",", "height", "of", "fracture", "and", "cancellous", "bone", "of", "the", "metaphysis", "of", "the", "opposite", "fracture", "part", ")", ".", "From", "1996", "to", "1999", "86", "children", "with", "fractures", "of", "the", "humerus", ",", "the", "fore", "-", "arm", "and", "the", "femur", "were", "operated", "in", "the", "technique", "of", "intramedullary", "nailing", ".", "The", "fractures", "affected", "the", "humerus", "to", "3.5", "%", ",", "the", "fore", "-", "arm", "to", "65.1", "%", "and", "the", "femoral", "shaft", "to", "31.4", "%", ".", "The", "postoperativ", "duration", "of", "stay", "in", "hospital", "after", "internal", "fixation", "of", "the", "fore", "-", "arm", "in", "the", "proximal", "and", "middle", "third", "lasted", "7.2", "days", ",", "the", "duration", "of", "immobilisation", "in", "a", "cast", "took", "13.7", "days", ".", "96", "%", "of", "the", "patients", "showed", "very", "good", "and", "good", "results", "after", "operation", ".", "The", "average", "stay", "in", "hospital", "for", "patients", "with", "femoral", "shaft", "fractures", "was", "14.4", "days", ".", "17", "weeks", "after", "operation", "the", "intramedullary", "nails", "were", "removed", ".", "At", "the", "time", "of", "first", "full", "weight", "bearing", "the", "legs", "showed", "an", "average", "shortening", "of", "1.2", "cm", ".", "The", "fractures", "of", "the", "humerus", "healed", "without", "any", "restriction", "of", "movements", ".", "Internal", "fixation", "is", "a", "minimal", "invasive", "operation", "technique", "with", "low", "risks", "and", "small", "operating", "trauma", ".", "Due", "to", "the", "stability", "a", "early", "mobilisation", "is", "possible", ".", "The", "reported", "results", "in", "the", "literature", "are", "all", "good", ".", "The", "only", "problem", "can", "be", "caused", "by", "too", "long", "nails", "irritating", "the", "skin", "." ]	[ "umlsterm" ]
fixation of fractures, bones, method, fracture, bone, fracture, children, fractures, humerus, femur, technique, intramedullary nailing, humerus, hospital, immobilisation, patients, operation, hospital, patients, fractures, operation, intramedullary nails, time, weight, legs, fractures, humerus, movements, operation, technique, risks, trauma, early mobilisation, literature, nails, skin	DerUnfallchirurg.01030002.eng.abstr_task2	Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .	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Patricia is a NOMBRE_SUJETO_ASISTENCIA, Montero Iglesias is a NOMBRE_SUJETO_ASISTENCIA, 3467890 is a ID_SUJETO_ASISTENCIA, 89 56734809 36 is a ID_ASEGURAMIENTO, Vigo is a TERRITORIO, 36201 is a TERRITORIO, 04/7/1940 is a FECHAS, España is a PAIS, 76 años is a EDAD_SUJETO_ASISTENCIA, 03/06/2017 is a FECHAS, 7348563 is a ID_CONTACTO_ASISTENCIAL, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36 28 57410 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 76 años is a EDAD_SUJETO_ASISTENCIA, 1992 is a FECHAS, año 2000 is a FECHAS, 2002 is a FECHAS, agosto de 2005 is a FECHAS, 25 de agosto is a FECHAS, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36201 is a TERRITORIO, Vigo is a TERRITORIO, ngomez@povisa.es is a CORREO_ELECTRONICO	164_task0	Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. 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Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. 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Patricia is a NOMBRE_SUJETO_ASISTENCIA, Montero Iglesias is a NOMBRE_SUJETO_ASISTENCIA, 3467890 is a ID_SUJETO_ASISTENCIA, 89 56734809 36 is a ID_ASEGURAMIENTO, Vigo is a TERRITORIO, 36201 is a TERRITORIO, 04/7/1940 is a FECHAS, España is a PAIS, 76 años is a EDAD_SUJETO_ASISTENCIA, 03/06/2017 is a FECHAS, 7348563 is a ID_CONTACTO_ASISTENCIAL, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36 28 57410 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 76 años is a EDAD_SUJETO_ASISTENCIA, 1992 is a FECHAS, año 2000 is a FECHAS, 2002 is a FECHAS, agosto de 2005 is a FECHAS, 25 de agosto is a FECHAS, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36201 is a TERRITORIO, Vigo is a TERRITORIO, ngomez@povisa.es is a CORREO_ELECTRONICO	164_task1	Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. 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Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. 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Patricia, Montero Iglesias, 3467890, 89 56734809 36, Vigo, 36201, 04/7/1940, España, 76 años, 03/06/2017, 7348563, Nora Gómez Rodríguez, 36 28 57410, Mujer, 76 años, 1992, año 2000, 2002, agosto de 2005, 25 de agosto, Nora Gómez Rodríguez, 36201, Vigo, ngomez@povisa.es	164_task2	Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. 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Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. 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Metformin is a CHEMICAL, phenformin is a CHEMICAL, AMP - activated protein kinase is a GENE-N, AMP is a CHEMICAL	17369473_task0	Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O" ]	Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.	[ "Metformin", "and", "phenformin", "activate", "AMP", "-", "activated", "protein", "kinase", "in", "the", "heart", "by", "increasing", "cytosolic", "AMP", "concentration", "." ]	[ "GENE-N", "CHEMICAL" ]
Metformin is a CHEMICAL, phenformin is a CHEMICAL, AMP - activated protein kinase is a GENE-N, AMP is a CHEMICAL	17369473_task1	Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please typing these entity words according to sentence: Metformin, phenformin, AMP - activated protein kinase, AMP Options: GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O" ]	Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.	[ "Metformin", "and", "phenformin", "activate", "AMP", "-", "activated", "protein", "kinase", "in", "the", "heart", "by", "increasing", "cytosolic", "AMP", "concentration", "." ]	[ "GENE-N", "CHEMICAL" ]
Metformin, phenformin, AMP - activated protein kinase, AMP	17369473_task2	Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O" ]	Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.	[ "Metformin", "and", "phenformin", "activate", "AMP", "-", "activated", "protein", "kinase", "in", "the", "heart", "by", "increasing", "cytosolic", "AMP", "concentration", "." ]	[ "GENE-N", "CHEMICAL" ]
glutathione is a compound, glutathione peroxidase is a protein, superoxide dismutase is a protein, catalase is a protein	DS.d509_task0	Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	[ "In", "the", "diabetic", "group", ",", "a", "decrease", "in", "the", "pancreatic", "glutathione", "levels", ",", "glutathione", "peroxidase", "and", "superoxide", "dismutase", "activities", "and", "an", "increase", "in", "the", "pancreatic", "lipid", "peroxidation", "level", "and", "catalase", "activities", "were", "observed", "." ]	[ "protein", "compound" ]
glutathione is a compound, glutathione peroxidase is a protein, superoxide dismutase is a protein, catalase is a protein	DS.d509_task1	Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please typing these entity words according to sentence: glutathione, glutathione peroxidase, superoxide dismutase, catalase Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	[ "In", "the", "diabetic", "group", ",", "a", "decrease", "in", "the", "pancreatic", "glutathione", "levels", ",", "glutathione", "peroxidase", "and", "superoxide", "dismutase", "activities", "and", "an", "increase", "in", "the", "pancreatic", "lipid", "peroxidation", "level", "and", "catalase", "activities", "were", "observed", "." ]	[ "protein", "compound" ]
glutathione, glutathione peroxidase, superoxide dismutase, catalase	DS.d509_task2	Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	[ "In", "the", "diabetic", "group", ",", "a", "decrease", "in", "the", "pancreatic", "glutathione", "levels", ",", "glutathione", "peroxidase", "and", "superoxide", "dismutase", "activities", "and", "an", "increase", "in", "the", "pancreatic", "lipid", "peroxidation", "level", "and", "catalase", "activities", "were", "observed", "." ]	[ "protein", "compound" ]
magnetic resonance spectroscopy is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, measurement is an umlsterm, phosphates is an umlsterm, phospholipids is an umlsterm, human is an umlsterm, brain is an umlsterm, patients is an umlsterm, controls is an umlsterm, review is an umlsterm, survey is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, comments is an umlsterm, phospholipids is an umlsterm, patients is an umlsterm, membrane is an umlsterm, phospholipid is an umlsterm, neuroleptic is an umlsterm, medication is an umlsterm	DerNervenarzt.00710354.eng.abstr_task0	Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .	[ "31Phosphorus", "nuclear", "magnetic", "resonance", "spectroscopy", "(", "31P", "-", "MRS", ")", "has", "gained", "much", "interest", "in", "schizophrenia", "research", "in", "the", "last", "years", ",", "since", "it", "allows", "noninvasive", "measurement", "of", "high", "energy", "phosphates", "and", "phospholipids", "of", "the", "human", "brain", "in", "vivo", ".", "Thus", ",", "several", "studies", "have", "reported", "cerebral", "metabolic", "differences", "between", "patients", "and", "healthy", "controls", "as", "well", "as", "on", "lateralization", "effects", "and", "influences", "of", "epidemiological", "and", "psychopathological", "factors", ".", "This", "review", "gives", "a", "survey", "of", "the", "potential", "of", "31P", "-", "MRS", "in", "schizophrenia", "research", "and", "summarizes", "and", "comments", "on", "the", "results", "of", "preceding", "studies", ".", "The", "discussion", "covers", "the", "reduction", "of", "phospholipids", "in", "patients", "in", "the", "context", "of", "the", "membrane", "phospholipid", "hypotheses", ",", "the", "question", "of", "an", "energetic", "hypometabolism", "in", "schizophrenics", ",", "and", "the", "influence", "of", "neuroleptic", "medication", "." ]	[ "umlsterm" ]
magnetic resonance spectroscopy is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, measurement is an umlsterm, phosphates is an umlsterm, phospholipids is an umlsterm, human is an umlsterm, brain is an umlsterm, patients is an umlsterm, controls is an umlsterm, review is an umlsterm, survey is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, comments is an umlsterm, phospholipids is an umlsterm, patients is an umlsterm, membrane is an umlsterm, phospholipid is an umlsterm, neuroleptic is an umlsterm, medication is an umlsterm	DerNervenarzt.00710354.eng.abstr_task1	Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please typing these entity words according to sentence: magnetic resonance spectroscopy, schizophrenia, research, measurement, phosphates, phospholipids, human, brain, patients, controls, review, survey, schizophrenia, research, comments, phospholipids, patients, membrane, phospholipid, neuroleptic, medication Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .	[ "31Phosphorus", "nuclear", "magnetic", "resonance", "spectroscopy", "(", "31P", "-", "MRS", ")", "has", "gained", "much", "interest", "in", "schizophrenia", "research", "in", "the", "last", "years", ",", "since", "it", "allows", "noninvasive", "measurement", "of", "high", "energy", "phosphates", "and", "phospholipids", "of", "the", "human", "brain", "in", "vivo", ".", "Thus", ",", "several", "studies", "have", "reported", "cerebral", "metabolic", "differences", "between", "patients", "and", "healthy", "controls", "as", "well", "as", "on", "lateralization", "effects", "and", "influences", "of", "epidemiological", "and", "psychopathological", "factors", ".", "This", "review", "gives", "a", "survey", "of", "the", "potential", "of", "31P", "-", "MRS", "in", "schizophrenia", "research", "and", "summarizes", "and", "comments", "on", "the", "results", "of", "preceding", "studies", ".", "The", "discussion", "covers", "the", "reduction", "of", "phospholipids", "in", "patients", "in", "the", "context", "of", "the", "membrane", "phospholipid", "hypotheses", ",", "the", "question", "of", "an", "energetic", "hypometabolism", "in", "schizophrenics", ",", "and", "the", "influence", "of", "neuroleptic", "medication", "." ]	[ "umlsterm" ]
magnetic resonance spectroscopy, schizophrenia, research, measurement, phosphates, phospholipids, human, brain, patients, controls, review, survey, schizophrenia, research, comments, phospholipids, patients, membrane, phospholipid, neuroleptic, medication	DerNervenarzt.00710354.eng.abstr_task2	Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .	[ "31Phosphorus", "nuclear", "magnetic", "resonance", "spectroscopy", "(", "31P", "-", "MRS", ")", "has", "gained", "much", "interest", "in", "schizophrenia", "research", "in", "the", "last", "years", ",", "since", "it", "allows", "noninvasive", "measurement", "of", "high", "energy", "phosphates", "and", "phospholipids", "of", "the", "human", "brain", "in", "vivo", ".", "Thus", ",", "several", "studies", "have", "reported", "cerebral", "metabolic", "differences", "between", "patients", "and", "healthy", "controls", "as", "well", "as", "on", "lateralization", "effects", "and", "influences", "of", "epidemiological", "and", "psychopathological", "factors", ".", "This", "review", "gives", "a", "survey", "of", "the", "potential", "of", "31P", "-", "MRS", "in", "schizophrenia", "research", "and", "summarizes", "and", "comments", "on", "the", "results", "of", "preceding", "studies", ".", "The", "discussion", "covers", "the", "reduction", "of", "phospholipids", "in", "patients", "in", "the", "context", "of", "the", "membrane", "phospholipid", "hypotheses", ",", "the", "question", "of", "an", "energetic", "hypometabolism", "in", "schizophrenics", ",", "and", "the", "influence", "of", "neuroleptic", "medication", "." ]	[ "umlsterm" ]
heart rate is an umlsterm, Methods is an umlsterm, fractal is an umlsterm, method is an umlsterm, behavior is an umlsterm, techniques is an umlsterm, analysis is an umlsterm, monitor is an umlsterm, Instruments is an umlsterm, time is an umlsterm, analysis is an umlsterm, time is an umlsterm, axis is an umlsterm, reproduction is an umlsterm, behavior is an umlsterm, period is an umlsterm, behavior is an umlsterm, heart rate is an umlsterm, method is an umlsterm, time is an umlsterm	Herzschrittmachertherapie.80090212.eng.abstr_task0	Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .	[ "The", "description", "of", "heart", "rate", "variability", "(", "HRV", ")", "by", "statistical", "and", "spectral", "parameters", "is", "a", "problem", "not", "yet", "satisfactorally", "solved", ".", "Methods", "of", "the", "fractal", "geometry", "might", "provide", "some", "advantages", "because", "not", "only", "the", "length", "of", "RR", "-", "intervals", "(", "RRI", ")", "but", "the", "information", "derived", "from", "the", "order", "of", "RRI", "is", "considered", ".", "This", "method", "is", "expected", "to", "allow", "differentiation", "between", "chance", "and", "deterministic", "chaotic", "behavior", ".", "Hence", ",", "we", "developed", "techniques", "for", "the", "description", "of", "HRV", "by", "means", "of", "dimension", "analysis", ".", "The", "course", "of", "information", "dimension", "(", "ID", ")", "over", "24h", "in", "20", "healthy", "probands", "was", "estimated", "from", "a", "digital", "holter", "monitor", "recording", "(", "sampling", "rate", "1000Hz", ",", "holter", "recorder", "FD3", "Oxford", "Instruments", ")", ".", "For", "that", "we", "calculated", "ID", "from", "a", "time", "window", "of", "2500", "RRI", "for", "the", "embedding", "dimension", "2", "up", "to", "6", ".", "The", "analysis", "window", "was", "subsequently", "moved", "forward", "along", "a", "time", "axis", "in", "steps", "of", "1000", "RRI", ".", "The", "graphical", "reproduction", "of", "ID", "courses", "over", "24h", "showed", "irregularly", "alternating", "phases", "of", "chance", "and", "deterministic", "chaotic", "behavior", "during", "the", "day", ".", "Conversely", "during", "the", "night", "two", "different", "patterns", "were", "demonstrated", ":", "either", "a", "persistant", "phase", "of", "increased", "chance", "or", "a", "period", "of", "deterministic", "chaotic", "behavior", "predominated", ".", "A", "significant", "correlation", "neither", "with", "heart", "rate", "nor", "with", "other", "collected", "or", "calculated", "data", "could", "be", "shown", ".", "Our", "method", "is", "able", "to", "asses", "ID", "over", "time", "as", "well", "as", "with", "increasing", "embedding", "dimensions", ".", "So", "beside", "statistical", "and", "spectral", "parameters", "there", "is", "a", "further", "new", "tool", "for", "HRV", "description", "available", ".", "Following", "studies", "have", "to", "elucidate", "clinical", "aspects", "." ]	[ "umlsterm" ]
heart rate is an umlsterm, Methods is an umlsterm, fractal is an umlsterm, method is an umlsterm, behavior is an umlsterm, techniques is an umlsterm, analysis is an umlsterm, monitor is an umlsterm, Instruments is an umlsterm, time is an umlsterm, analysis is an umlsterm, time is an umlsterm, axis is an umlsterm, reproduction is an umlsterm, behavior is an umlsterm, period is an umlsterm, behavior is an umlsterm, heart rate is an umlsterm, method is an umlsterm, time is an umlsterm	Herzschrittmachertherapie.80090212.eng.abstr_task1	Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please typing these entity words according to sentence: heart rate, Methods, fractal, method, behavior, techniques, analysis, monitor, Instruments, time, analysis, time, axis, reproduction, behavior, period, behavior, heart rate, method, time Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .	[ "The", "description", "of", "heart", "rate", "variability", "(", "HRV", ")", "by", "statistical", "and", "spectral", "parameters", "is", "a", "problem", "not", "yet", "satisfactorally", "solved", ".", "Methods", "of", "the", "fractal", "geometry", "might", "provide", "some", "advantages", "because", "not", "only", "the", "length", "of", "RR", "-", "intervals", "(", "RRI", ")", "but", "the", "information", "derived", "from", "the", "order", "of", "RRI", "is", "considered", ".", "This", "method", "is", "expected", "to", "allow", "differentiation", "between", "chance", "and", "deterministic", "chaotic", "behavior", ".", "Hence", ",", "we", "developed", "techniques", "for", "the", "description", "of", "HRV", "by", "means", "of", "dimension", "analysis", ".", "The", "course", "of", "information", "dimension", "(", "ID", ")", "over", "24h", "in", "20", "healthy", "probands", "was", "estimated", "from", "a", "digital", "holter", "monitor", "recording", "(", "sampling", "rate", "1000Hz", ",", "holter", "recorder", "FD3", "Oxford", "Instruments", ")", ".", "For", "that", "we", "calculated", "ID", "from", "a", "time", "window", "of", "2500", "RRI", "for", "the", "embedding", "dimension", "2", "up", "to", "6", ".", "The", "analysis", "window", "was", "subsequently", "moved", "forward", "along", "a", "time", "axis", "in", "steps", "of", "1000", "RRI", ".", "The", "graphical", "reproduction", "of", "ID", "courses", "over", "24h", "showed", "irregularly", "alternating", "phases", "of", "chance", "and", "deterministic", "chaotic", "behavior", "during", "the", "day", ".", "Conversely", "during", "the", "night", "two", "different", "patterns", "were", "demonstrated", ":", "either", "a", "persistant", "phase", "of", "increased", "chance", "or", "a", "period", "of", "deterministic", "chaotic", "behavior", "predominated", ".", "A", "significant", "correlation", "neither", "with", "heart", "rate", "nor", "with", "other", "collected", "or", "calculated", "data", "could", "be", "shown", ".", "Our", "method", "is", "able", "to", "asses", "ID", "over", "time", "as", "well", "as", "with", "increasing", "embedding", "dimensions", ".", "So", "beside", "statistical", "and", "spectral", "parameters", "there", "is", "a", "further", "new", "tool", "for", "HRV", "description", "available", ".", "Following", "studies", "have", "to", "elucidate", "clinical", "aspects", "." ]	[ "umlsterm" ]
heart rate, Methods, fractal, method, behavior, techniques, analysis, monitor, Instruments, time, analysis, time, axis, reproduction, behavior, period, behavior, heart rate, method, time	Herzschrittmachertherapie.80090212.eng.abstr_task2	Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .	[ "The", "description", "of", "heart", "rate", "variability", "(", "HRV", ")", "by", "statistical", "and", "spectral", "parameters", "is", "a", "problem", "not", "yet", "satisfactorally", "solved", ".", "Methods", "of", "the", "fractal", "geometry", "might", "provide", "some", "advantages", "because", "not", "only", "the", "length", "of", "RR", "-", "intervals", "(", "RRI", ")", "but", "the", "information", "derived", "from", "the", "order", "of", "RRI", "is", "considered", ".", "This", "method", "is", "expected", "to", "allow", "differentiation", "between", "chance", "and", "deterministic", "chaotic", "behavior", ".", "Hence", ",", "we", "developed", "techniques", "for", "the", "description", "of", "HRV", "by", "means", "of", "dimension", "analysis", ".", "The", "course", "of", "information", "dimension", "(", "ID", ")", "over", "24h", "in", "20", "healthy", "probands", "was", "estimated", "from", "a", "digital", "holter", "monitor", "recording", "(", "sampling", "rate", "1000Hz", ",", "holter", "recorder", "FD3", "Oxford", "Instruments", ")", ".", "For", "that", "we", "calculated", "ID", "from", "a", "time", "window", "of", "2500", "RRI", "for", "the", "embedding", "dimension", "2", "up", "to", "6", ".", "The", "analysis", "window", "was", "subsequently", "moved", "forward", "along", "a", "time", "axis", "in", "steps", "of", "1000", "RRI", ".", "The", "graphical", "reproduction", "of", "ID", "courses", "over", "24h", "showed", "irregularly", "alternating", "phases", "of", "chance", "and", "deterministic", "chaotic", "behavior", "during", "the", "day", ".", "Conversely", "during", "the", "night", "two", "different", "patterns", "were", "demonstrated", ":", "either", "a", "persistant", "phase", "of", "increased", "chance", "or", "a", "period", "of", "deterministic", "chaotic", "behavior", "predominated", ".", "A", "significant", "correlation", "neither", "with", "heart", "rate", "nor", "with", "other", "collected", "or", "calculated", "data", "could", "be", "shown", ".", "Our", "method", "is", "able", "to", "asses", "ID", "over", "time", "as", "well", "as", "with", "increasing", "embedding", "dimensions", ".", "So", "beside", "statistical", "and", "spectral", "parameters", "there", "is", "a", "further", "new", "tool", "for", "HRV", "description", "available", ".", "Following", "studies", "have", "to", "elucidate", "clinical", "aspects", "." ]	[ "umlsterm" ]
human spermidine / spermine N1-acetyltransferase is a GENE-Y	16455797_task0	Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]	Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.	[ "Structures", "of", "wild", "-", "type", "and", "mutant", "human", "spermidine", "/", "spermine", "N1-acetyltransferase", ",", "a", "potential", "therapeutic", "drug", "target", "." ]	[ "GENE-Y", "CHEMICAL" ]
human spermidine / spermine N1-acetyltransferase is a GENE-Y	16455797_task1	Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please typing these entity words according to sentence: human spermidine / spermine N1-acetyltransferase Options: GENE-Y	[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]	Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.	[ "Structures", "of", "wild", "-", "type", "and", "mutant", "human", "spermidine", "/", "spermine", "N1-acetyltransferase", ",", "a", "potential", "therapeutic", "drug", "target", "." ]	[ "GENE-Y", "CHEMICAL" ]
human spermidine / spermine N1-acetyltransferase	16455797_task2	Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]	Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.	[ "Structures", "of", "wild", "-", "type", "and", "mutant", "human", "spermidine", "/", "spermine", "N1-acetyltransferase", ",", "a", "potential", "therapeutic", "drug", "target", "." ]	[ "GENE-Y", "CHEMICAL" ]
Glutamate Receptor is a GENE-N	23590882_task0	Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.	[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]	[ "GENE-N", "CHEMICAL" ]
Glutamate Receptor is a GENE-N	23590882_task1	Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please typing these entity words according to sentence: Glutamate Receptor Options: GENE-N	[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.	[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]	[ "GENE-N", "CHEMICAL" ]
Glutamate Receptor	23590882_task2	Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please extract entity words from the input sentence	[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.	[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]	[ "GENE-N", "CHEMICAL" ]
Effects of surfactant is a Outcome_Other, biofilm formation is a Outcome_Physical, silicone nasal splints . is a Outcome_Physical, Biofilms is a Intervention_Pharmacological, biofilm formation . is a Outcome_Physical, Forty patients is a Participant_Sample-size, septoplasty is a Intervention_Surgical, surfactant - containing saline solution ( group is a Intervention_Pharmacological, saline without surfactant is a Intervention_Pharmacological, scanning electron microscopic evaluation is a Outcome_Other, Biofilm formation is a Outcome_Physical, Surfactant - containing nasal solutions is a Intervention_Pharmacological, nasal septal dressing is a Outcome_Physical	65763_task0	Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical	[ "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .	[ "Effects", "of", "surfactant", "on", "biofilm", "formation", "on", "silicone", "nasal", "splints", ".", "Biofilms", "are", "sessile", "communities", "of", "bacteria", "embedded", "in", "self", "-", "produced", "extracellular", "polysaccharide", "matrix", "and", "are", "considered", "to", "be", "responsible", "for", "bacterial", "infections", "in", "humans", ".", "Topical", "surfactant", "use", "on", "silicone", "nasal", "splints", "may", "have", "a", "preventive", "effect", "on", "biofilm", "formation", ".", "The", "objective", "of", "this", "study", "is", "to", "investigate", "the", "effect", "of", "surfactant", "-", "containing", "nasal", "solutions", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", ".", "Forty", "patients", "were", "randomized", "after", "septoplasty", "to", "receive", "surfactant", "-", "containing", "saline", "solution", "(", "group", "1", ")", "or", "saline", "without", "surfactant", "(", "group", "2", ")", ".", "At", "the", "postoperative", "48th", ",", "72th", "and", "96th", "hours", ",", "pieces", "of", "splint", "samples", "were", "taken", "and", "prepared", "for", "scanning", "electron", "microscopic", "evaluation", ".", "Biofilm", "formation", "was", "observed", "in", "3", ",", "6", "and", "14", "of", "20", "samples", "in", "group", "1", "(", "surfactant", "used", ")", "and", "3", ",", "14", "and", "20", "of", "20", "samples", "in", "group", "2", "(", "control", ")", "at", "48th", ",", "72th", "and", "96th", "hours", ",", "respectively", ".", "Biofilm", "formation", "incidences", "of", "groups", "at", "48th", "hour", "were", "similar", "(", "p", ">", "0.05", ")", ",", "whereas", "it", "was", "significantly", "lower", "at", "group", "1", "regarding", "72th", "and", "96th", "hours", "(", "p", "<", "0.05", ")", ".", "Surfactant", "-", "containing", "nasal", "solutions", "have", "an", "inhibitory", "effect", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", "especially", "after", "48", "h.", "Surfactant", "-", "containing", "nasal", "solutions", "may", "have", "an", "important", "role", "in", "nasal", "septal", "dressing", "in", "the", "future", "." ]	[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]
Effects of surfactant is a Outcome_Other, biofilm formation is a Outcome_Physical, silicone nasal splints . is a Outcome_Physical, Biofilms is a Intervention_Pharmacological, biofilm formation . is a Outcome_Physical, Forty patients is a Participant_Sample-size, septoplasty is a Intervention_Surgical, surfactant - containing saline solution ( group is a Intervention_Pharmacological, saline without surfactant is a Intervention_Pharmacological, scanning electron microscopic evaluation is a Outcome_Other, Biofilm formation is a Outcome_Physical, Surfactant - containing nasal solutions is a Intervention_Pharmacological, nasal septal dressing is a Outcome_Physical	65763_task1	Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please typing these entity words according to sentence: Effects of surfactant, biofilm formation, silicone nasal splints ., Biofilms, biofilm formation ., Forty patients, septoplasty, surfactant - containing saline solution ( group, saline without surfactant, scanning electron microscopic evaluation, Biofilm formation, Surfactant - containing nasal solutions, nasal septal dressing Options: Intervention_Pharmacological, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical	[ "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .	[ "Effects", "of", "surfactant", "on", "biofilm", "formation", "on", "silicone", "nasal", "splints", ".", "Biofilms", "are", "sessile", "communities", "of", "bacteria", "embedded", "in", "self", "-", "produced", "extracellular", "polysaccharide", "matrix", "and", "are", "considered", "to", "be", "responsible", "for", "bacterial", "infections", "in", "humans", ".", "Topical", "surfactant", "use", "on", "silicone", "nasal", "splints", "may", "have", "a", "preventive", "effect", "on", "biofilm", "formation", ".", "The", "objective", "of", "this", "study", "is", "to", "investigate", "the", "effect", "of", "surfactant", "-", "containing", "nasal", "solutions", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", ".", "Forty", "patients", "were", "randomized", "after", "septoplasty", "to", "receive", "surfactant", "-", "containing", "saline", "solution", "(", "group", "1", ")", "or", "saline", "without", "surfactant", "(", "group", "2", ")", ".", "At", "the", "postoperative", "48th", ",", "72th", "and", "96th", "hours", ",", "pieces", "of", "splint", "samples", "were", "taken", "and", "prepared", "for", "scanning", "electron", "microscopic", "evaluation", ".", "Biofilm", "formation", "was", "observed", "in", "3", ",", "6", "and", "14", "of", "20", "samples", "in", "group", "1", "(", "surfactant", "used", ")", "and", "3", ",", "14", "and", "20", "of", "20", "samples", "in", "group", "2", "(", "control", ")", "at", "48th", ",", "72th", "and", "96th", "hours", ",", "respectively", ".", "Biofilm", "formation", "incidences", "of", "groups", "at", "48th", "hour", "were", "similar", "(", "p", ">", "0.05", ")", ",", "whereas", "it", "was", "significantly", "lower", "at", "group", "1", "regarding", "72th", "and", "96th", "hours", "(", "p", "<", "0.05", ")", ".", "Surfactant", "-", "containing", "nasal", "solutions", "have", "an", "inhibitory", "effect", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", "especially", "after", "48", "h.", "Surfactant", "-", "containing", "nasal", "solutions", "may", "have", "an", "important", "role", "in", "nasal", "septal", "dressing", "in", "the", "future", "." ]	[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]
Effects of surfactant, biofilm formation, silicone nasal splints ., Biofilms, biofilm formation ., Forty patients, septoplasty, surfactant - containing saline solution ( group, saline without surfactant, scanning electron microscopic evaluation, Biofilm formation, Surfactant - containing nasal solutions, nasal septal dressing	65763_task2	Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please extract entity words from the input sentence	[ "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .	[ "Effects", "of", "surfactant", "on", "biofilm", "formation", "on", "silicone", "nasal", "splints", ".", "Biofilms", "are", "sessile", "communities", "of", "bacteria", "embedded", "in", "self", "-", "produced", "extracellular", "polysaccharide", "matrix", "and", "are", "considered", "to", "be", "responsible", "for", "bacterial", "infections", "in", "humans", ".", "Topical", "surfactant", "use", "on", "silicone", "nasal", "splints", "may", "have", "a", "preventive", "effect", "on", "biofilm", "formation", ".", "The", "objective", "of", "this", "study", "is", "to", "investigate", "the", "effect", "of", "surfactant", "-", "containing", "nasal", "solutions", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", ".", "Forty", "patients", "were", "randomized", "after", "septoplasty", "to", "receive", "surfactant", "-", "containing", "saline", "solution", "(", "group", "1", ")", "or", "saline", "without", "surfactant", "(", "group", "2", ")", ".", "At", "the", "postoperative", "48th", ",", "72th", "and", "96th", "hours", ",", "pieces", "of", "splint", "samples", "were", "taken", "and", "prepared", "for", "scanning", "electron", "microscopic", "evaluation", ".", "Biofilm", "formation", "was", "observed", "in", "3", ",", "6", "and", "14", "of", "20", "samples", "in", "group", "1", "(", "surfactant", "used", ")", "and", "3", ",", "14", "and", "20", "of", "20", "samples", "in", "group", "2", "(", "control", ")", "at", "48th", ",", "72th", "and", "96th", "hours", ",", "respectively", ".", "Biofilm", "formation", "incidences", "of", "groups", "at", "48th", "hour", "were", "similar", "(", "p", ">", "0.05", ")", ",", "whereas", "it", "was", "significantly", "lower", "at", "group", "1", "regarding", "72th", "and", "96th", "hours", "(", "p", "<", "0.05", ")", ".", "Surfactant", "-", "containing", "nasal", "solutions", "have", "an", "inhibitory", "effect", "on", "biofilm", "formation", "over", "the", "surface", "of", "silicone", "nasal", "splints", "especially", "after", "48", "h.", "Surfactant", "-", "containing", "nasal", "solutions", "may", "have", "an", "important", "role", "in", "nasal", "septal", "dressing", "in", "the", "future", "." ]	[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]
alcohol dehydrogenase is a protein, ADH is a protein, G6PDH is a protein, ethyl-3-oxobutanoate is a compound, EOB is a compound, S)-3-hydroxybutanoate is a compound	DS.d1676_task0	Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	[ "The", "effects", "of", "industrial", "storage", "on", "the", "changes", "of", "the", "cell", "viability", "and", "the", "activities", "of", "intracellular", "alcohol", "dehydrogenase", "(", "ADH", ")", "and", "glucose-6-phosphate", "dehydrogenase", "(", "G6PDH", ")", "in", "brewer", "'s", "yeast", ",", "and", "the", "corresponding", "capacity", "for", "the", "bioconversion", "of", "ethyl-3-oxobutanoate", "(", "EOB", ")", "to", "ethyl", "(", "S)-3-hydroxybutanoate", "(", "(", "S)-EHB", ")", ",", "were", "investigated", "." ]	[ "protein", "compound" ]
alcohol dehydrogenase is a protein, ADH is a protein, G6PDH is a protein, ethyl-3-oxobutanoate is a compound, EOB is a compound, S)-3-hydroxybutanoate is a compound	DS.d1676_task1	Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please typing these entity words according to sentence: alcohol dehydrogenase, ADH, G6PDH, ethyl-3-oxobutanoate, EOB, S)-3-hydroxybutanoate Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	[ "The", "effects", "of", "industrial", "storage", "on", "the", "changes", "of", "the", "cell", "viability", "and", "the", "activities", "of", "intracellular", "alcohol", "dehydrogenase", "(", "ADH", ")", "and", "glucose-6-phosphate", "dehydrogenase", "(", "G6PDH", ")", "in", "brewer", "'s", "yeast", ",", "and", "the", "corresponding", "capacity", "for", "the", "bioconversion", "of", "ethyl-3-oxobutanoate", "(", "EOB", ")", "to", "ethyl", "(", "S)-3-hydroxybutanoate", "(", "(", "S)-EHB", ")", ",", "were", "investigated", "." ]	[ "protein", "compound" ]
alcohol dehydrogenase, ADH, G6PDH, ethyl-3-oxobutanoate, EOB, S)-3-hydroxybutanoate	DS.d1676_task2	Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	[ "The", "effects", "of", "industrial", "storage", "on", "the", "changes", "of", "the", "cell", "viability", "and", "the", "activities", "of", "intracellular", "alcohol", "dehydrogenase", "(", "ADH", ")", "and", "glucose-6-phosphate", "dehydrogenase", "(", "G6PDH", ")", "in", "brewer", "'s", "yeast", ",", "and", "the", "corresponding", "capacity", "for", "the", "bioconversion", "of", "ethyl-3-oxobutanoate", "(", "EOB", ")", "to", "ethyl", "(", "S)-3-hydroxybutanoate", "(", "(", "S)-EHB", ")", ",", "were", "investigated", "." ]	[ "protein", "compound" ]
Age is a Person, = 18 years is a Value, American Society of Anesthesiologists Classification is a Observation, I - III is a Value, Normal is a Value, cognitive function is a Measurement, Agreement to the trial protocol is a Observation	NCT03372265_inc_task0	Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Person, Measurement, Observation, Value	[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]	Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner	[ "Age", "=", "18", "years", "\n", "American", "Society", "of", "Anesthesiologists", "Classification", "I", "-", "III", "\n", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "\n", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner", "\n" ]	[ "Observation", "Measurement", "Value", "Person" ]
Age is a Person, = 18 years is a Value, American Society of Anesthesiologists Classification is a Observation, I - III is a Value, Normal is a Value, cognitive function is a Measurement, Agreement to the trial protocol is a Observation	NCT03372265_inc_task1	Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please typing these entity words according to sentence: Age, = 18 years, American Society of Anesthesiologists Classification, I - III, Normal, cognitive function, Agreement to the trial protocol Options: Person, Measurement, Observation, Value	[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]	Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner	[ "Age", "=", "18", "years", "\n", "American", "Society", "of", "Anesthesiologists", "Classification", "I", "-", "III", "\n", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "\n", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner", "\n" ]	[ "Observation", "Measurement", "Value", "Person" ]
Age, = 18 years, American Society of Anesthesiologists Classification, I - III, Normal, cognitive function, Agreement to the trial protocol	NCT03372265_inc_task2	Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please extract entity words from the input sentence	[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]	Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner	[ "Age", "=", "18", "years", "\n", "American", "Society", "of", "Anesthesiologists", "Classification", "I", "-", "III", "\n", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "\n", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner", "\n" ]	[ "Observation", "Measurement", "Value", "Person" ]
relative is an umlsterm, thrombolytic is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, thrombus is an umlsterm, clinical studies is an umlsterm, case reports is an umlsterm, patients is an umlsterm, therapy is an umlsterm, recommendations is an umlsterm, choice is an umlsterm, therapy is an umlsterm, therapy is an umlsterm, contraindications is an umlsterm, literature review is an umlsterm	IntensiveMedizin.80350620.eng.abstr_task0	Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .	[ "The", "relative", "success", "of", "thrombolytic", "versus", "surgical", "therapy", "of", "thrombus", "in", "transit", "has", "not", "yet", "been", "evaluated", "in", "clinical", "studies", ".", "Only", "case", "reports", "of", "one", "or", "more", "patients", "exist", ".", "Optimal", "therapy", ",", "therefore", ",", "remains", "controversial", ",", "and", "conclusive", "recommendations", "in", "favor", "of", "one", "choice", "of", "therapy", "over", "the", "other", "cannot", "be", "given", ".", "Nevertheless", ",", "in", "current", "practice", "thrombolysis", "as", "a", "noninvasive", "and", "quickly", "available", "form", "of", "therapy", "is", "preferred", ",", "if", "no", "contraindications", "exist", ".", "Two", "cases", "are", "presented", "together", "with", "a", "literature", "review", "." ]	[ "umlsterm" ]
relative is an umlsterm, thrombolytic is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, thrombus is an umlsterm, clinical studies is an umlsterm, case reports is an umlsterm, patients is an umlsterm, therapy is an umlsterm, recommendations is an umlsterm, choice is an umlsterm, therapy is an umlsterm, therapy is an umlsterm, contraindications is an umlsterm, literature review is an umlsterm	IntensiveMedizin.80350620.eng.abstr_task1	Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please typing these entity words according to sentence: relative, thrombolytic, surgical, therapy, thrombus, clinical studies, case reports, patients, therapy, recommendations, choice, therapy, therapy, contraindications, literature review Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .	[ "The", "relative", "success", "of", "thrombolytic", "versus", "surgical", "therapy", "of", "thrombus", "in", "transit", "has", "not", "yet", "been", "evaluated", "in", "clinical", "studies", ".", "Only", "case", "reports", "of", "one", "or", "more", "patients", "exist", ".", "Optimal", "therapy", ",", "therefore", ",", "remains", "controversial", ",", "and", "conclusive", "recommendations", "in", "favor", "of", "one", "choice", "of", "therapy", "over", "the", "other", "cannot", "be", "given", ".", "Nevertheless", ",", "in", "current", "practice", "thrombolysis", "as", "a", "noninvasive", "and", "quickly", "available", "form", "of", "therapy", "is", "preferred", ",", "if", "no", "contraindications", "exist", ".", "Two", "cases", "are", "presented", "together", "with", "a", "literature", "review", "." ]	[ "umlsterm" ]
relative, thrombolytic, surgical, therapy, thrombus, clinical studies, case reports, patients, therapy, recommendations, choice, therapy, therapy, contraindications, literature review	IntensiveMedizin.80350620.eng.abstr_task2	Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .	[ "The", "relative", "success", "of", "thrombolytic", "versus", "surgical", "therapy", "of", "thrombus", "in", "transit", "has", "not", "yet", "been", "evaluated", "in", "clinical", "studies", ".", "Only", "case", "reports", "of", "one", "or", "more", "patients", "exist", ".", "Optimal", "therapy", ",", "therefore", ",", "remains", "controversial", ",", "and", "conclusive", "recommendations", "in", "favor", "of", "one", "choice", "of", "therapy", "over", "the", "other", "cannot", "be", "given", ".", "Nevertheless", ",", "in", "current", "practice", "thrombolysis", "as", "a", "noninvasive", "and", "quickly", "available", "form", "of", "therapy", "is", "preferred", ",", "if", "no", "contraindications", "exist", ".", "Two", "cases", "are", "presented", "together", "with", "a", "literature", "review", "." ]	[ "umlsterm" ]
Schleudertrauma is an umlsterm, Diagnosen is an umlsterm, Verkehrsunfaellen is an umlsterm, bildgebende Diagnostik is an umlsterm, Diagnostik is an umlsterm	ManuelleMedizin.90370079.ger.abstr_task0	Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .	[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]	[ "umlsterm" ]
Schleudertrauma is an umlsterm, Diagnosen is an umlsterm, Verkehrsunfaellen is an umlsterm, bildgebende Diagnostik is an umlsterm, Diagnostik is an umlsterm	ManuelleMedizin.90370079.ger.abstr_task1	Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please typing these entity words according to sentence: Schleudertrauma, Diagnosen, Verkehrsunfaellen, bildgebende Diagnostik, Diagnostik Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .	[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]	[ "umlsterm" ]
Schleudertrauma, Diagnosen, Verkehrsunfaellen, bildgebende Diagnostik, Diagnostik	ManuelleMedizin.90370079.ger.abstr_task2	Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .	[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]	[ "umlsterm" ]
survey is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, disease is an umlsterm, anal fissure is an umlsterm, therapies is an umlsterm, hospital is an umlsterm, therapeutic is an umlsterm, surgery is an umlsterm, choice is an umlsterm, operative procedure is an umlsterm, Future is an umlsterm, research is an umlsterm, standardization is an umlsterm, therapy is an umlsterm, disorders is an umlsterm	DerChirurg.80690215.eng.abstr_task0	Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .	[ "A", "survey", "among", "coloproctologists", "was", "performed", "to", "assess", "current", "therapeutic", "concepts", "for", "the", "treatment", "of", "hemorrhoidal", "disease", "and", "anal", "fissure", ".", "A", "total", "of", "261", "clinical", "and", "non", "-", "clinical", "proctologists", "participated", ",", "representing", "the", "entire", "range", "of", "therapies", "in", "hospital", "and", "practise", ".", "A", "wealth", "of", "widely", "differing", ",", "in", "some", "aspects", "contradictory", "concepts", "were", "recorded", ",", "leaving", "almost", "no", "subject", "entirely", "undisputed", ".", "There", "are", "controversies", "regarding", "the", "different", "therapeutic", "alternatives", "as", "well", "as", "indications", "for", "surgery", "and", "choice", "of", "operative", "procedure", ".", "Future", "research", "has", "to", "address", "the", "existing", "controversies", "in", "order", "to", "reach", "a", "higher", "degree", "of", "standardization", "in", "the", "therapy", "of", "these", "common", "proctological", "disorders", "." ]	[ "umlsterm" ]
survey is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, disease is an umlsterm, anal fissure is an umlsterm, therapies is an umlsterm, hospital is an umlsterm, therapeutic is an umlsterm, surgery is an umlsterm, choice is an umlsterm, operative procedure is an umlsterm, Future is an umlsterm, research is an umlsterm, standardization is an umlsterm, therapy is an umlsterm, disorders is an umlsterm	DerChirurg.80690215.eng.abstr_task1	Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please typing these entity words according to sentence: survey, therapeutic, treatment, disease, anal fissure, therapies, hospital, therapeutic, surgery, choice, operative procedure, Future, research, standardization, therapy, disorders Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .	[ "A", "survey", "among", "coloproctologists", "was", "performed", "to", "assess", "current", "therapeutic", "concepts", "for", "the", "treatment", "of", "hemorrhoidal", "disease", "and", "anal", "fissure", ".", "A", "total", "of", "261", "clinical", "and", "non", "-", "clinical", "proctologists", "participated", ",", "representing", "the", "entire", "range", "of", "therapies", "in", "hospital", "and", "practise", ".", "A", "wealth", "of", "widely", "differing", ",", "in", "some", "aspects", "contradictory", "concepts", "were", "recorded", ",", "leaving", "almost", "no", "subject", "entirely", "undisputed", ".", "There", "are", "controversies", "regarding", "the", "different", "therapeutic", "alternatives", "as", "well", "as", "indications", "for", "surgery", "and", "choice", "of", "operative", "procedure", ".", "Future", "research", "has", "to", "address", "the", "existing", "controversies", "in", "order", "to", "reach", "a", "higher", "degree", "of", "standardization", "in", "the", "therapy", "of", "these", "common", "proctological", "disorders", "." ]	[ "umlsterm" ]
survey, therapeutic, treatment, disease, anal fissure, therapies, hospital, therapeutic, surgery, choice, operative procedure, Future, research, standardization, therapy, disorders	DerChirurg.80690215.eng.abstr_task2	Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .	[ "A", "survey", "among", "coloproctologists", "was", "performed", "to", "assess", "current", "therapeutic", "concepts", "for", "the", "treatment", "of", "hemorrhoidal", "disease", "and", "anal", "fissure", ".", "A", "total", "of", "261", "clinical", "and", "non", "-", "clinical", "proctologists", "participated", ",", "representing", "the", "entire", "range", "of", "therapies", "in", "hospital", "and", "practise", ".", "A", "wealth", "of", "widely", "differing", ",", "in", "some", "aspects", "contradictory", "concepts", "were", "recorded", ",", "leaving", "almost", "no", "subject", "entirely", "undisputed", ".", "There", "are", "controversies", "regarding", "the", "different", "therapeutic", "alternatives", "as", "well", "as", "indications", "for", "surgery", "and", "choice", "of", "operative", "procedure", ".", "Future", "research", "has", "to", "address", "the", "existing", "controversies", "in", "order", "to", "reach", "a", "higher", "degree", "of", "standardization", "in", "the", "therapy", "of", "these", "common", "proctological", "disorders", "." ]	[ "umlsterm" ]
Morbidity is an umlsterm, mortality is an umlsterm, procedure is an umlsterm, sigmoid is an umlsterm, diverticulitis is an umlsterm, procedure is an umlsterm, procedure is an umlsterm, patient is an umlsterm, Method is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, All is an umlsterm, patients is an umlsterm, surgery is an umlsterm, procedure is an umlsterm, patients is an umlsterm, patient is an umlsterm, technique is an umlsterm, technique is an umlsterm, patients is an umlsterm, time is an umlsterm, wound infections is an umlsterm, postoperative complications is an umlsterm, Patients is an umlsterm, convalescence is an umlsterm, surgery is an umlsterm, nutrition is an umlsterm, surgery is an umlsterm, postoperative is an umlsterm, hospitalisation is an umlsterm, patient is an umlsterm, dilatation is an umlsterm, Postoperative is an umlsterm, morbidity is an umlsterm, hospitalisation is an umlsterm, convalescence is an umlsterm, procedures is an umlsterm	DerChirurg.90701139.eng.abstr_task0	Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .	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Morbidity is an umlsterm, mortality is an umlsterm, procedure is an umlsterm, sigmoid is an umlsterm, diverticulitis is an umlsterm, procedure is an umlsterm, procedure is an umlsterm, patient is an umlsterm, Method is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, All is an umlsterm, patients is an umlsterm, surgery is an umlsterm, procedure is an umlsterm, patients is an umlsterm, patient is an umlsterm, technique is an umlsterm, technique is an umlsterm, patients is an umlsterm, time is an umlsterm, wound infections is an umlsterm, postoperative complications is an umlsterm, Patients is an umlsterm, convalescence is an umlsterm, surgery is an umlsterm, nutrition is an umlsterm, surgery is an umlsterm, postoperative is an umlsterm, hospitalisation is an umlsterm, patient is an umlsterm, dilatation is an umlsterm, Postoperative is an umlsterm, morbidity is an umlsterm, hospitalisation is an umlsterm, convalescence is an umlsterm, procedures is an umlsterm	DerChirurg.90701139.eng.abstr_task1	Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . Instructions: please typing these entity words according to sentence: Morbidity, mortality, procedure, sigmoid, diverticulitis, procedure, procedure, patient, Method, patients, postoperative, All, patients, surgery, procedure, patients, patient, technique, technique, patients, time, wound infections, postoperative complications, Patients, convalescence, surgery, nutrition, surgery, postoperative, hospitalisation, patient, dilatation, Postoperative, morbidity, hospitalisation, convalescence, procedures Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .	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Morbidity, mortality, procedure, sigmoid, diverticulitis, procedure, procedure, patient, Method, patients, postoperative, All, patients, surgery, procedure, patients, patient, technique, technique, patients, time, wound infections, postoperative complications, Patients, convalescence, surgery, nutrition, surgery, postoperative, hospitalisation, patient, dilatation, Postoperative, morbidity, hospitalisation, convalescence, procedures	DerChirurg.90701139.eng.abstr_task2	Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . 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Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .	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Patricia is a NOMBRE_SUJETO_ASISTENCIA, Rojo Martinez is a NOMBRE_SUJETO_ASISTENCIA, 56 41365424 10 is a ID_ASEGURAMIENTO, Rúa Salvador Dalí , 2 is a CALLE, Ourense is a TERRITORIO, 32002 is a TERRITORIO, 74513689 is a ID_SUJETO_ASISTENCIA, 30/03/19 is a FECHAS, España is a PAIS, 60 años is a EDAD_SUJETO_ASISTENCIA, 04/09/2017 is a FECHAS, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, 32 28 16479 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 60 años is a EDAD_SUJETO_ASISTENCIA, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, Complexo Hospitalario Universitario de Ourense is a HOSPITAL, 32002 is a TERRITORIO, Ourense is a TERRITORIO, España is a PAIS, maria.teresa.fernandez.lopez@sergas.es is a CORREO_ELECTRONICO	147_task0	Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO	[ "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "O", "O", "O", "O", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "B-SEXO_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. 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Patricia is a NOMBRE_SUJETO_ASISTENCIA, Rojo Martinez is a NOMBRE_SUJETO_ASISTENCIA, 56 41365424 10 is a ID_ASEGURAMIENTO, Rúa Salvador Dalí , 2 is a CALLE, Ourense is a TERRITORIO, 32002 is a TERRITORIO, 74513689 is a ID_SUJETO_ASISTENCIA, 30/03/19 is a FECHAS, España is a PAIS, 60 años is a EDAD_SUJETO_ASISTENCIA, 04/09/2017 is a FECHAS, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, 32 28 16479 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 60 años is a EDAD_SUJETO_ASISTENCIA, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, Complexo Hospitalario Universitario de Ourense is a HOSPITAL, 32002 is a TERRITORIO, Ourense is a TERRITORIO, España is a PAIS, maria.teresa.fernandez.lopez@sergas.es is a CORREO_ELECTRONICO	147_task1	Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please typing these entity words according to sentence: Patricia, Rojo Martinez, 56 41365424 10, Rúa Salvador Dalí , 2, Ourense, 32002, 74513689, 30/03/19, España, 60 años, 04/09/2017, María Teresa Fernández López, 32 28 16479, Mujer, 60 años, María Teresa Fernández López, Complexo Hospitalario Universitario de Ourense, 32002, Ourense, España, maria.teresa.fernandez.lopez@sergas.es Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO	[ "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "O", "O", "O", "O", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "B-SEXO_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es	[ "Nombre", ":", " ", "Patricia", ".", "\n", "Apellidos", ":", "Rojo", "Martinez", ".", "\n", "NASS", ":", "56", "41365424", "10", ".", "\n", "Domicilio", ":", "Rúa", "Salvador", "Dalí", ",", "2", ".", "\n", "Localidad/", "Provincia", ":", "Ourense", ".", "\n", "CP", ":", "32002", ".", "\n", "NHC", ":", "74513689", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "30/03/19", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "60", "años", "Sexo", ":", "M.", "\n", "Fecha", "de", "Ingreso", ":", "04/09/2017", ".", "\n", "Especialidad", ":", "Endocrinología", ".", "\n", "Médico", ":", "María", "Teresa", "Fernández", "López", "NºCol", ":", "32", "28", "16479", ".", "\n", "Historia", "Actual", ":", "Mujer", "de", "60", "años", "diagnosticada", "de", "neoplasia", "gástrica", "antral", "estenosante", ".", "Se", "realizó", "una", "gastrectomía", "subtotal", "con", "reconstrucción", "en", "Y", "de", "Roux", ".", "En", "el", "día", "+7", "la", "paciente", "se", "deterioró", "de", "forma", "brusca", "con", "aparición", "de", "datos", "de", "peritonitis", ",", "por", "lo", "que", "se", "sometió", "a", "laparotomía", "urgente", ",", "observándose", "necrosis", "de", "curvatura", "menor", "gástrica", "y", "de", "cara", "anterior", "de", "esófago", "distal", ".", "Se", "practicó", "transección", "y", "cierre", "de", "esófago", "abdominal", "y", "muñón", "gástrico", ",", "exclusión", "esofágica", "con", "esofagostomía", "cervical", "y", "se", "colocó", "yeyunostomía", "de", "alimentación", ",", "iniciándose", "NE", "en", "el", "día", "+1", ".", "La", "paciente", "fue", "dada", "de", "alta", "con", "NED", "por", "yeyunostomía", ".", "A", "los", "tres", "meses", "reingresó", "para", "reconstruir", "el", "tránsito", "digestivo", ",", "previa", "realización", "de", "colonoscopia", "y", "tomografía", "axial", "computerizada", "en", "las", "que", "no", "se", "objetivaron", "datos", "sugestivos", "de", "recidiva", "tumoral", ".", "Durante", "la", "cirugía", "se", "observaron", "múltiples", "micronódulos", "a", "nivel", "de", "colon", "transverso", "y", "en", "la", "región", "correspondiente", "al", "epiplon", "gastrohepático", ",", "con", "anatomía", "patológica", "intraoperatoria", "compatible", "con", "células", "en", "anillo", "de", "sello", ",", "por", "lo", "que", "se", "suspendió", "la", "reconstrucción", "y", "se", "mantuvo", "NED", "por", "yeyunostomía", "de", "forma", "indefinida", ".", "\n", "Remitido", "por", ":", "María", "Teresa", "Fernández", "López", ".", "Médico", "Adjunto", "del", "Servicio", "de", "Endocrinología", "y", "Nutrición", ".", "Complexo", "Hospitalario", "Universitario", "de", "Ourense", ".", "C/", "Villa", "Valencia", ",", "20", "-", "6o", "A.", "32002", "Ourense", ".", "España", ".", "E", "-", "mail", ":", "maria.teresa.fernandez.lopez@sergas.es", "\n" ]	[ "HOSPITAL", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "CALLE", "ID_ASEGURAMIENTO", "NOMBRE_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "ID_SUJETO_ASISTENCIA", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
Patricia, Rojo Martinez, 56 41365424 10, Rúa Salvador Dalí , 2, Ourense, 32002, 74513689, 30/03/19, España, 60 años, 04/09/2017, María Teresa Fernández López, 32 28 16479, Mujer, 60 años, María Teresa Fernández López, Complexo Hospitalario Universitario de Ourense, 32002, Ourense, España, maria.teresa.fernandez.lopez@sergas.es	147_task2	Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "I-ID_ASEGURAMIENTO", "O", "O", "O", "O", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "B-SEXO_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es	[ "Nombre", ":", " ", "Patricia", ".", "\n", "Apellidos", ":", "Rojo", "Martinez", ".", "\n", "NASS", ":", "56", "41365424", "10", ".", "\n", "Domicilio", ":", "Rúa", "Salvador", "Dalí", ",", "2", ".", "\n", "Localidad/", "Provincia", ":", "Ourense", ".", "\n", "CP", ":", "32002", ".", "\n", "NHC", ":", "74513689", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "30/03/19", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "60", "años", "Sexo", ":", "M.", "\n", "Fecha", "de", "Ingreso", ":", "04/09/2017", ".", "\n", "Especialidad", ":", "Endocrinología", ".", "\n", "Médico", ":", "María", "Teresa", "Fernández", "López", "NºCol", ":", "32", "28", "16479", ".", "\n", "Historia", "Actual", ":", "Mujer", "de", "60", "años", "diagnosticada", "de", "neoplasia", "gástrica", "antral", "estenosante", ".", "Se", "realizó", "una", "gastrectomía", "subtotal", "con", "reconstrucción", "en", "Y", "de", "Roux", ".", "En", "el", "día", "+7", "la", "paciente", "se", "deterioró", "de", "forma", "brusca", "con", "aparición", "de", "datos", "de", "peritonitis", ",", "por", "lo", "que", "se", "sometió", "a", "laparotomía", "urgente", ",", "observándose", "necrosis", "de", "curvatura", "menor", "gástrica", "y", "de", "cara", "anterior", "de", "esófago", "distal", ".", "Se", "practicó", "transección", "y", "cierre", "de", "esófago", "abdominal", "y", "muñón", "gástrico", ",", "exclusión", "esofágica", "con", "esofagostomía", "cervical", "y", "se", "colocó", "yeyunostomía", "de", "alimentación", ",", "iniciándose", "NE", "en", "el", "día", "+1", ".", "La", "paciente", "fue", "dada", "de", "alta", "con", "NED", "por", "yeyunostomía", ".", "A", "los", "tres", "meses", "reingresó", "para", "reconstruir", "el", "tránsito", "digestivo", ",", "previa", "realización", "de", "colonoscopia", "y", "tomografía", "axial", "computerizada", "en", "las", "que", "no", "se", "objetivaron", "datos", "sugestivos", "de", "recidiva", "tumoral", ".", "Durante", "la", "cirugía", "se", "observaron", "múltiples", "micronódulos", "a", "nivel", "de", "colon", "transverso", "y", "en", "la", "región", "correspondiente", "al", "epiplon", "gastrohepático", ",", "con", "anatomía", "patológica", "intraoperatoria", "compatible", "con", "células", "en", "anillo", "de", "sello", ",", "por", "lo", "que", "se", "suspendió", "la", "reconstrucción", "y", "se", "mantuvo", "NED", "por", "yeyunostomía", "de", "forma", "indefinida", ".", "\n", "Remitido", "por", ":", "María", "Teresa", "Fernández", "López", ".", "Médico", "Adjunto", "del", "Servicio", "de", "Endocrinología", "y", "Nutrición", ".", "Complexo", "Hospitalario", "Universitario", "de", "Ourense", ".", "C/", "Villa", "Valencia", ",", "20", "-", "6o", "A.", "32002", "Ourense", ".", "España", ".", "E", "-", "mail", ":", "maria.teresa.fernandez.lopez@sergas.es", "\n" ]	[ "HOSPITAL", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "CALLE", "ID_ASEGURAMIENTO", "NOMBRE_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "ID_SUJETO_ASISTENCIA", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
Ernaehrung is an umlsterm, Sport is an umlsterm, Rehabilitation is an umlsterm, muskelzellulaeren is an umlsterm, Kohlenhydrate is an umlsterm, Fettsaeuren is an umlsterm, Proteine is an umlsterm, gezielte is an umlsterm, Sportlerernaehrung is an umlsterm, sportspezifische is an umlsterm, Belastung is an umlsterm, muskelzellulaeren is an umlsterm, Stress is an umlsterm, Kreatinkinase is an umlsterm, Myoglobin is an umlsterm, Belastung is an umlsterm, Zytokine is an umlsterm, Interleukin is an umlsterm, Akutphase - proteine is an umlsterm, Fibrinogen is an umlsterm, Stresshormons is an umlsterm, Cortisol is an umlsterm, Belastung is an umlsterm, Mineralstoffen is an umlsterm, Magnesium is an umlsterm, Vitaminen A is an umlsterm, -Carotin is an umlsterm, sportinduzierten is an umlsterm, Muskel- is an umlsterm, Sporttreibenden is an umlsterm, Belastung is an umlsterm	DerOrthopaede.70260942.ger.abstr_task0	Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .	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Ernaehrung is an umlsterm, Sport is an umlsterm, Rehabilitation is an umlsterm, muskelzellulaeren is an umlsterm, Kohlenhydrate is an umlsterm, Fettsaeuren is an umlsterm, Proteine is an umlsterm, gezielte is an umlsterm, Sportlerernaehrung is an umlsterm, sportspezifische is an umlsterm, Belastung is an umlsterm, muskelzellulaeren is an umlsterm, Stress is an umlsterm, Kreatinkinase is an umlsterm, Myoglobin is an umlsterm, Belastung is an umlsterm, Zytokine is an umlsterm, Interleukin is an umlsterm, Akutphase - proteine is an umlsterm, Fibrinogen is an umlsterm, Stresshormons is an umlsterm, Cortisol is an umlsterm, Belastung is an umlsterm, Mineralstoffen is an umlsterm, Magnesium is an umlsterm, Vitaminen A is an umlsterm, -Carotin is an umlsterm, sportinduzierten is an umlsterm, Muskel- is an umlsterm, Sporttreibenden is an umlsterm, Belastung is an umlsterm	DerOrthopaede.70260942.ger.abstr_task1	Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please typing these entity words according to sentence: Ernaehrung, Sport, Rehabilitation, muskelzellulaeren, Kohlenhydrate, Fettsaeuren, Proteine, gezielte, Sportlerernaehrung, sportspezifische, Belastung, muskelzellulaeren, Stress, Kreatinkinase, Myoglobin, Belastung, Zytokine, Interleukin, Akutphase - proteine, Fibrinogen, Stresshormons, Cortisol, Belastung, Mineralstoffen, Magnesium, Vitaminen A, -Carotin, sportinduzierten, Muskel-, Sporttreibenden, Belastung Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .	[ "Die", "Betrachtung", "des", "Themenkomplexes", "Ernaehrung", "und", "Sport", "wird", "heute", "weniger", "in", "Verbindung", "mit", "einer", "moeglichen", "Leistungsverbesserung", ",", "sondern", "in", "zunehmenden", "Masse", "unter", "dem", "Aspekt", "der", "Praevention", "und", "Rehabilitation", "von", "systemischen", "und", "muskelzellulaeren", "Ueberlastungsphaenomenen", "gesehen", ".", "Unter", "Beruecksichtigung", "der", "Thematik", "dieser", "Ausgabe", "wird", "im", "folgenden", "Text", "daher", "nicht", "auf", "die", "Bedeutung", "der", "Naehrstoffe", "Kohlenhydrate", ",", "Fettsaeuren", "und", "Proteine", "als", "Energielieferanten", "eingegangen", ",", "sondern", "die", "gezielte", "Sportlerernaehrung", "unter", "dem", "Gesichtspunkt", "der", "Beeinflussung", "der", "Belastungsreaktion", "des", "trainierenden", "Organismus", "betrachtet", ".", "Die", "sportspezifische", "Belastung", "spiegelt", "sich", "in", "erhoehtem", "muskelzellulaeren", "Stress", ",", "messbar", "vor", "allem", "ueber", "einen", "Anstieg", "von", "Kreatinkinase", "und", "Myoglobin", "im", "Serum", "sowie", "in", "einer", "systemischen", "(", "ca", ".", "1", "-", "48", "h", "nach", "Belastung", ")", "immunologischen", "hormonellen", "und", "Akutphase", "-", "reaktion", ",", "wider", ".", "Insbesondere", "der", "Verlauf", "der", "Zytokine", "(", "vor", "allem", "Interleukin", "6", ")", ",", "der", "Akutphase", "-", "proteine", "CRP", "und", "Fibrinogen", "und", "des", "Stresshormons", "Cortisol", "geben", "Hinweise", "auf", "die", "Belastungsintensitaet", "bzw", ".", "die", "individuelle", "Verarbeitung", "der", "koerperlichen", "Belastung", ".", "Forschungsergebnisse", "weisen", "vor", "allem", "den", "Mineralstoffen", "Magnesium", "und", "Zink", ",", "den", "Vitaminen", "A", ",", "C", ",", "E", "und", "-Carotin", "sowie", "der", "Zusammensetzung", "der", "Nahrungsfettsaeuren", "eine", "wesentliche", "Bedeutung", "bei", "der", "Verminderung", "der", "sportinduzierten", "Muskel-", "und", "Ganzkoerperbelastungsreaktion", "zu", ".", "Im", "der", "vorliegenden", "Uebersicht", "wird", "daher", "auf", "die", "Bedeutung", "dieser", "Naehrstoffe", "bei", "intensiv", "Sporttreibenden", "-", "unter", "besonderer", "Beruecksichtigung", "eines", "vermehrten", "Verlustes", "oder", "Bedarfs", "waehrend", "oder", "nach", "koerperlicher", "Belastung", "-", "eingegangen", "und", "moegliche", "Auswirkungen", "eines", "Defizits", "diskutiert", "." ]	[ "umlsterm" ]
Ernaehrung, Sport, Rehabilitation, muskelzellulaeren, Kohlenhydrate, Fettsaeuren, Proteine, gezielte, Sportlerernaehrung, sportspezifische, Belastung, muskelzellulaeren, Stress, Kreatinkinase, Myoglobin, Belastung, Zytokine, Interleukin, Akutphase - proteine, Fibrinogen, Stresshormons, Cortisol, Belastung, Mineralstoffen, Magnesium, Vitaminen A, -Carotin, sportinduzierten, Muskel-, Sporttreibenden, Belastung	DerOrthopaede.70260942.ger.abstr_task2	Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .	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recommendations is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, coronary heart disease is an umlsterm, Society is an umlsterm, Cardiology is an umlsterm, Atherosclerosis is an umlsterm, Society is an umlsterm, Society is an umlsterm, Hypertension is an umlsterm, objective is an umlsterm, Secondary is an umlsterm, Prevention is an umlsterm, recommendations is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, Germany is an umlsterm, Methods is an umlsterm, patients is an umlsterm, medical records is an umlsterm, hospital is an umlsterm, patients is an umlsterm, coronary artery bypass is an umlsterm, graft is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, myocardial infarction is an umlsterm, myocardial ischemia is an umlsterm, patients is an umlsterm, goal is an umlsterm, patients is an umlsterm, interview is an umlsterm, hospital is an umlsterm, discharge is an umlsterm, patients is an umlsterm, interview is an umlsterm, evaluation is an umlsterm, risk is an umlsterm, interview is an umlsterm, patients is an umlsterm, obese is an umlsterm, blood pressure is an umlsterm, Risk factor is an umlsterm, time is an umlsterm, patients is an umlsterm, values is an umlsterm, risk factors is an umlsterm, time is an umlsterm, interview is an umlsterm, goals is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, treatment is an umlsterm, patients is an umlsterm, secondary is an umlsterm, prevention is an umlsterm	ZfuerKardiologie.70860284.eng.abstr_task0	Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .	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recommendations is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, coronary heart disease is an umlsterm, Society is an umlsterm, Cardiology is an umlsterm, Atherosclerosis is an umlsterm, Society is an umlsterm, Society is an umlsterm, Hypertension is an umlsterm, objective is an umlsterm, Secondary is an umlsterm, Prevention is an umlsterm, recommendations is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, Germany is an umlsterm, Methods is an umlsterm, patients is an umlsterm, medical records is an umlsterm, hospital is an umlsterm, patients is an umlsterm, coronary artery bypass is an umlsterm, graft is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, myocardial infarction is an umlsterm, myocardial ischemia is an umlsterm, patients is an umlsterm, goal is an umlsterm, patients is an umlsterm, interview is an umlsterm, hospital is an umlsterm, discharge is an umlsterm, patients is an umlsterm, interview is an umlsterm, evaluation is an umlsterm, risk is an umlsterm, interview is an umlsterm, patients is an umlsterm, obese is an umlsterm, blood pressure is an umlsterm, Risk factor is an umlsterm, time is an umlsterm, patients is an umlsterm, values is an umlsterm, risk factors is an umlsterm, time is an umlsterm, interview is an umlsterm, goals is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, treatment is an umlsterm, patients is an umlsterm, secondary is an umlsterm, prevention is an umlsterm	ZfuerKardiologie.70860284.eng.abstr_task1	Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please typing these entity words according to sentence: recommendations, secondary, prevention, coronary heart disease, Society, Cardiology, Atherosclerosis, Society, Society, Hypertension, objective, Secondary, Prevention, recommendations, risk factor, patients, Germany, Methods, patients, medical records, hospital, patients, coronary artery bypass, graft, angioplasty, PTCA, myocardial infarction, myocardial ischemia, patients, goal, patients, interview, hospital, discharge, patients, interview, evaluation, risk, interview, patients, obese, blood pressure, Risk factor, time, patients, values, risk factors, time, interview, goals, secondary, prevention, treatment, patients, secondary, prevention Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .	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recommendations, secondary, prevention, coronary heart disease, Society, Cardiology, Atherosclerosis, Society, Society, Hypertension, objective, Secondary, Prevention, recommendations, risk factor, patients, Germany, Methods, patients, medical records, hospital, patients, coronary artery bypass, graft, angioplasty, PTCA, myocardial infarction, myocardial ischemia, patients, goal, patients, interview, hospital, discharge, patients, interview, evaluation, risk, interview, patients, obese, blood pressure, Risk factor, time, patients, values, risk factors, time, interview, goals, secondary, prevention, treatment, patients, secondary, prevention	ZfuerKardiologie.70860284.eng.abstr_task2	Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .	[ "New", "recommendations", "for", "secondary", "prevention", "of", "coronary", "heart", "disease", "(", "CHD", ")", "were", "issued", "by", "the", "European", "Society", "of", "Cardiology", "(", "ESC", ")", ",", "the", "European", "Atherosclerosis", "Society", "(", "EAS", ")", "and", "the", "European", "Society", "of", "Hypertension", "(", "ESH", ")", "in", "1994", ".", "The", "main", "objective", "of", "the", "EUROASPIRE", "study", "(", "European", "Action", "on", "Secondary", "Prevention", "by", "Intervention", "to", "Reduce", "Events", ")", "was", "to", "evaluate", "to", "what", "degree", "the", "new", "recommendations", "have", "been", "implemented", "and", "whether", "a", "significant", "risk", "factor", "reduction", "in", "patients", "who", "presented", "with", "CHD", "has", "been", "achieved", ".", "The", "present", "study", "was", "conducted", "in", "the", "region", "of", "Muenster", ",", "Westphalia", ",", "Germany", ",", "as", "part", "of", "the", "nine", "-", "country", "EUROASPIRE", "study", ".", "Methods", ":", "A", "total", "of", "524", "patients", "(", "58.6", "+", "8.2", "years", ")", "were", "included", "in", "the", "study", "by", "abstracting", "data", "from", "their", "medical", "records", ".", "According", "to", "the", "clinical", "event", "which", "led", "to", "admission", "to", "the", "hospital", ",", "patients", "belonged", "to", "the", "following", "four", "groups", ":", "1", ")", "coronary", "artery", "bypass", "graft", "(", "CABG", ")", ",", "2", ")", "percutaneous", "transluminal", "coronary", "angioplasty", "(", "PTCA", ")", ",", "3", ")", "acute", "myocardial", "infarction", ",", "4", ")", "acute", "myocardial", "ischemia", ".", "Initially", ",", "a", "pre", "-", "specified", "number", "of", "patients", "had", "been", "recruited", "with", "the", "goal", "of", "having", "100", "patients", "in", "each", "of", "the", "four", "groups", "participate", "in", "the", "follow", "-", "up", "interview", "and", "examination", ".", "At", "least", "6", "months", "and", ",", "on", "average", ",", "20", "months", "after", "hospital", "discharge", "for", "the", "acute", "event", ",", "74.8", "%", "of", "the", "patients", "came", "to", "an", "interview", "and", "examination", "for", "an", "evaluation", "of", "their", "risk", "profile", ".", "Results", ":", "At", "the", "interview", ",", "15.6", "%", "of", "the", "patients", "smoked", ",", "22.7", "%", "were", "obese", ",", "54.6", "%", "had", "blood", "pressure", "levels", "above", "14090", "mm", "Hg", "and", "31.3", "%", "a", "total", "cholesterolHDL", "-", "cholesterol", "-", "ratio", "greater", "than", "5", ".", "Risk", "factor", "modification", "over", "time", "was", "insufficient", "as", "only", "one", "-", "fifth", "of", "patients", "had", "values", "of", "their", "risk", "factors", "within", "the", "target", "range", "at", "the", "time", "of", "the", "interview", ".", "Conclusion", ":", "The", "goals", "of", "secondary", "prevention", "have", "not", "been", "achieved", "in", "the", "region", "of", "Muenster", "-", "there", "is", "clearly", "room", "for", "improvement", ".", "Considering", "the", "treatment", "of", "patients", "with", "CHD", ",", "the", "recommended", "strategies", "of", "secondary", "prevention", "need", "to", "be", "applied", "more", "intensively", "in", "clinical", "practice", "." ]	[ "umlsterm" ]
hinteren Schaedelgrube is an umlsterm, Halswirbelsaeule is an umlsterm, Praxis is an umlsterm	DerAnaesthesist.00490269.ger.abstr_task0	Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .	[ "In", "einer", "1998", "durchgefuehrten", "Umfrage", "wurde", "der", "aktuelle", "Stand", "bezueglich", "Lagerung", "und", "Monitoring", "bei", "neurochirurgischen", "Eingriffen", "in", "der", "hinteren", "Schaedelgrube", ",", "des", "kraniospinalen", "Uebergangs", "und", "des", "dorsalen", "Zugangs", "zur", "oberen", "Halswirbelsaeule", "erhoben", ",", "um", "zum", "einen", "die", "Umsetzung", "bzw", ".", "Akzeptanz", "der", "1995", "veroeffentlichten", "Empfehlungen", "des", "Arbeitskreises", "Neuroanaesthesie", "der", "DGAI", "zum", "Monitoring", "bei", "diesen", "Operationen", "in", "der", "klinischen", "Praxis", "zu", "ueberpruefen", "und", "um", "zum", "anderen", "den", "Einsatz", "der", "sitzenden", "Position", "sowie", "alternativer", "Lagerungstechniken", "in", "einem", "3-Jahres", "-", "Intervall", "vergleichen", "zu", "koennen", "." ]	[ "umlsterm" ]
hinteren Schaedelgrube is an umlsterm, Halswirbelsaeule is an umlsterm, Praxis is an umlsterm	DerAnaesthesist.00490269.ger.abstr_task1	Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please typing these entity words according to sentence: hinteren Schaedelgrube, Halswirbelsaeule, Praxis Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .	[ "In", "einer", "1998", "durchgefuehrten", "Umfrage", "wurde", "der", "aktuelle", "Stand", "bezueglich", "Lagerung", "und", "Monitoring", "bei", "neurochirurgischen", "Eingriffen", "in", "der", "hinteren", "Schaedelgrube", ",", "des", "kraniospinalen", "Uebergangs", "und", "des", "dorsalen", "Zugangs", "zur", "oberen", "Halswirbelsaeule", "erhoben", ",", "um", "zum", "einen", "die", "Umsetzung", "bzw", ".", "Akzeptanz", "der", "1995", "veroeffentlichten", "Empfehlungen", "des", "Arbeitskreises", "Neuroanaesthesie", "der", "DGAI", "zum", "Monitoring", "bei", "diesen", "Operationen", "in", "der", "klinischen", "Praxis", "zu", "ueberpruefen", "und", "um", "zum", "anderen", "den", "Einsatz", "der", "sitzenden", "Position", "sowie", "alternativer", "Lagerungstechniken", "in", "einem", "3-Jahres", "-", "Intervall", "vergleichen", "zu", "koennen", "." ]	[ "umlsterm" ]
hinteren Schaedelgrube, Halswirbelsaeule, Praxis	DerAnaesthesist.00490269.ger.abstr_task2	Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .	[ "In", "einer", "1998", "durchgefuehrten", "Umfrage", "wurde", "der", "aktuelle", "Stand", "bezueglich", "Lagerung", "und", "Monitoring", "bei", "neurochirurgischen", "Eingriffen", "in", "der", "hinteren", "Schaedelgrube", ",", "des", "kraniospinalen", "Uebergangs", "und", "des", "dorsalen", "Zugangs", "zur", "oberen", "Halswirbelsaeule", "erhoben", ",", "um", "zum", "einen", "die", "Umsetzung", "bzw", ".", "Akzeptanz", "der", "1995", "veroeffentlichten", "Empfehlungen", "des", "Arbeitskreises", "Neuroanaesthesie", "der", "DGAI", "zum", "Monitoring", "bei", "diesen", "Operationen", "in", "der", "klinischen", "Praxis", "zu", "ueberpruefen", "und", "um", "zum", "anderen", "den", "Einsatz", "der", "sitzenden", "Position", "sowie", "alternativer", "Lagerungstechniken", "in", "einem", "3-Jahres", "-", "Intervall", "vergleichen", "zu", "koennen", "." ]	[ "umlsterm" ]
Pruritus is an umlsterm, Epiphora is an umlsterm, Histaminwirkungen is an umlsterm, Histamingehalts is an umlsterm, Histaminfreisetzung is an umlsterm	DerOpthalmologe.80950241.ger.abstr_task0	Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .	[ "Die", "vorherrschenden", "Symptome", "der", "Conjunctivitis", "allergica", "(", "Typ", "-", "I", "-", "Allergie", "Pruritus", "und", "Epiphora", ",", ")", ",", "sind", "den", "klinisch", "fassbaren", "Histaminwirkungen", "zuzurechnen", ".", "Messungen", "des", "Histamingehalts", "der", "Traenenfluessigkeit", "sollten", "Aufklaerung", "ueber", "die", "Dynamik", "dieser", "lokalen", "Histaminfreisetzung", "in", "Verbindung", "mit", "der", "klinischen", "Symptomatik", "bringen", "." ]	[ "umlsterm" ]
Pruritus is an umlsterm, Epiphora is an umlsterm, Histaminwirkungen is an umlsterm, Histamingehalts is an umlsterm, Histaminfreisetzung is an umlsterm	DerOpthalmologe.80950241.ger.abstr_task1	Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please typing these entity words according to sentence: Pruritus, Epiphora, Histaminwirkungen, Histamingehalts, Histaminfreisetzung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .	[ "Die", "vorherrschenden", "Symptome", "der", "Conjunctivitis", "allergica", "(", "Typ", "-", "I", "-", "Allergie", "Pruritus", "und", "Epiphora", ",", ")", ",", "sind", "den", "klinisch", "fassbaren", "Histaminwirkungen", "zuzurechnen", ".", "Messungen", "des", "Histamingehalts", "der", "Traenenfluessigkeit", "sollten", "Aufklaerung", "ueber", "die", "Dynamik", "dieser", "lokalen", "Histaminfreisetzung", "in", "Verbindung", "mit", "der", "klinischen", "Symptomatik", "bringen", "." ]	[ "umlsterm" ]
Pruritus, Epiphora, Histaminwirkungen, Histamingehalts, Histaminfreisetzung	DerOpthalmologe.80950241.ger.abstr_task2	Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .	[ "Die", "vorherrschenden", "Symptome", "der", "Conjunctivitis", "allergica", "(", "Typ", "-", "I", "-", "Allergie", "Pruritus", "und", "Epiphora", ",", ")", ",", "sind", "den", "klinisch", "fassbaren", "Histaminwirkungen", "zuzurechnen", ".", "Messungen", "des", "Histamingehalts", "der", "Traenenfluessigkeit", "sollten", "Aufklaerung", "ueber", "die", "Dynamik", "dieser", "lokalen", "Histaminfreisetzung", "in", "Verbindung", "mit", "der", "klinischen", "Symptomatik", "bringen", "." ]	[ "umlsterm" ]
Ekzems is an umlsterm, Basistherapie is an umlsterm, Therapie is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapie is an umlsterm, therapieresistenten is an umlsterm, Therapie is an umlsterm, Antihistaminika is an umlsterm, mikrobiellen Superinfektionen is an umlsterm, Antibiotika is an umlsterm, Aciclovir is an umlsterm, Azathioprin is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapieansaetze is an umlsterm	DerHautarzt.90500323.ger.abstr_task0	Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .	[ "Das", "Behandlungskonzept", "des", "atopischen", "Ekzems", "beinhaltet", "die", "kontinuierliche", "topische", "dermatologische", "Basistherapie", "in", "Kombination", "mit", "einer", "zeitlich", "begrenzten", "Exazerbations", "-", "gerichteten", "antiinflammatorischen", "Therapie", ".", "In", "der", "Behandlung", "des", "exazerbierten", "atopischen", "Ekzems", "werden", "vielfach", "Systemtherapeutika", "eingesetzt", ",", "um", "ein", "rasches", "und", "wirkungsvolles", "Ansprechen", "der", "topischen", "Therapie", "zu", "unterstuetzen", "oder", "bei", "therapieresistenten", "Verlaeufen", "eine", "Remission", "zu", "erzielen", ".", "Neben", "der", "adjuvanten", "Therapie", "mit", "Antihistaminika", "kommen", "bei", "mikrobiellen", "Superinfektionen", "orale", "Antibiotika", "und", "Aciclovir", "zum", "Einsatz", ".", "Einer", "Exazerbation", "kann", "vielfach", "phototherapeutisch", ",", "insbesondere", "durch", "eine", "UVA1-Behandlung", ",", "erfolgreich", "entgegnet", "werden", ".", "Auf", "den", "Einsatz", "von", "systemischen", "Immuntherapeutika", "wie", "Glukokortikosteroiden", ",", "Ciclosporin", "oder", "Azathioprin", "kann", "in", "der", "Regel", "bei", "der", "Behandlung", "des", "atopischen", "Ekzems", "verzichtet", "werden", "bzw", ".", "stellt", "nur", "in", "wenigen", "Ausnahmefaellen", "eine", "therapeutische", "Alternative", "dar", ".", "Es", "gibt", "vielversprechende", "neue", "experimentelle", "Therapieansaetze", ",", "die", "zukuenftige", "Behandlungsalternativen", "darstellen", "koennten", "." ]	[ "umlsterm" ]
Ekzems is an umlsterm, Basistherapie is an umlsterm, Therapie is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapie is an umlsterm, therapieresistenten is an umlsterm, Therapie is an umlsterm, Antihistaminika is an umlsterm, mikrobiellen Superinfektionen is an umlsterm, Antibiotika is an umlsterm, Aciclovir is an umlsterm, Azathioprin is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapieansaetze is an umlsterm	DerHautarzt.90500323.ger.abstr_task1	Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please typing these entity words according to sentence: Ekzems, Basistherapie, Therapie, Behandlung, Ekzems, Therapie, therapieresistenten, Therapie, Antihistaminika, mikrobiellen Superinfektionen, Antibiotika, Aciclovir, Azathioprin, Behandlung, Ekzems, Therapieansaetze Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .	[ "Das", "Behandlungskonzept", "des", "atopischen", "Ekzems", "beinhaltet", "die", "kontinuierliche", "topische", "dermatologische", "Basistherapie", "in", "Kombination", "mit", "einer", "zeitlich", "begrenzten", "Exazerbations", "-", "gerichteten", "antiinflammatorischen", "Therapie", ".", "In", "der", "Behandlung", "des", "exazerbierten", "atopischen", "Ekzems", "werden", "vielfach", "Systemtherapeutika", "eingesetzt", ",", "um", "ein", "rasches", "und", "wirkungsvolles", "Ansprechen", "der", "topischen", "Therapie", "zu", "unterstuetzen", "oder", "bei", "therapieresistenten", "Verlaeufen", "eine", "Remission", "zu", "erzielen", ".", "Neben", "der", "adjuvanten", "Therapie", "mit", "Antihistaminika", "kommen", "bei", "mikrobiellen", "Superinfektionen", "orale", "Antibiotika", "und", "Aciclovir", "zum", "Einsatz", ".", "Einer", "Exazerbation", "kann", "vielfach", "phototherapeutisch", ",", "insbesondere", "durch", "eine", "UVA1-Behandlung", ",", "erfolgreich", "entgegnet", "werden", ".", "Auf", "den", "Einsatz", "von", "systemischen", "Immuntherapeutika", "wie", "Glukokortikosteroiden", ",", "Ciclosporin", "oder", "Azathioprin", "kann", "in", "der", "Regel", "bei", "der", "Behandlung", "des", "atopischen", "Ekzems", "verzichtet", "werden", "bzw", ".", "stellt", "nur", "in", "wenigen", "Ausnahmefaellen", "eine", "therapeutische", "Alternative", "dar", ".", "Es", "gibt", "vielversprechende", "neue", "experimentelle", "Therapieansaetze", ",", "die", "zukuenftige", "Behandlungsalternativen", "darstellen", "koennten", "." ]	[ "umlsterm" ]
Ekzems, Basistherapie, Therapie, Behandlung, Ekzems, Therapie, therapieresistenten, Therapie, Antihistaminika, mikrobiellen Superinfektionen, Antibiotika, Aciclovir, Azathioprin, Behandlung, Ekzems, Therapieansaetze	DerHautarzt.90500323.ger.abstr_task2	Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .	[ "Das", "Behandlungskonzept", "des", "atopischen", "Ekzems", "beinhaltet", "die", "kontinuierliche", "topische", "dermatologische", "Basistherapie", "in", "Kombination", "mit", "einer", "zeitlich", "begrenzten", "Exazerbations", "-", "gerichteten", "antiinflammatorischen", "Therapie", ".", "In", "der", "Behandlung", "des", "exazerbierten", "atopischen", "Ekzems", "werden", "vielfach", "Systemtherapeutika", "eingesetzt", ",", "um", "ein", "rasches", "und", "wirkungsvolles", "Ansprechen", "der", "topischen", "Therapie", "zu", "unterstuetzen", "oder", "bei", "therapieresistenten", "Verlaeufen", "eine", "Remission", "zu", "erzielen", ".", "Neben", "der", "adjuvanten", "Therapie", "mit", "Antihistaminika", "kommen", "bei", "mikrobiellen", "Superinfektionen", "orale", "Antibiotika", "und", "Aciclovir", "zum", "Einsatz", ".", "Einer", "Exazerbation", "kann", "vielfach", "phototherapeutisch", ",", "insbesondere", "durch", "eine", "UVA1-Behandlung", ",", "erfolgreich", "entgegnet", "werden", ".", "Auf", "den", "Einsatz", "von", "systemischen", "Immuntherapeutika", "wie", "Glukokortikosteroiden", ",", "Ciclosporin", "oder", "Azathioprin", "kann", "in", "der", "Regel", "bei", "der", "Behandlung", "des", "atopischen", "Ekzems", "verzichtet", "werden", "bzw", ".", "stellt", "nur", "in", "wenigen", "Ausnahmefaellen", "eine", "therapeutische", "Alternative", "dar", ".", "Es", "gibt", "vielversprechende", "neue", "experimentelle", "Therapieansaetze", ",", "die", "zukuenftige", "Behandlungsalternativen", "darstellen", "koennten", "." ]	[ "umlsterm" ]
Sepsisbegriff is an umlsterm, Sepsis is an umlsterm, Patienten is an umlsterm, Immunsystems is an umlsterm, Entzuendungsmediatoren is an umlsterm, Toxinen is an umlsterm, Polytrauma is an umlsterm, Pankreatitis is an umlsterm, Monozyten is an umlsterm, Makrophagen is an umlsterm, Monozyten - Makrophagensystems is an umlsterm, Signaltransduktion is an umlsterm, Stressgenexpression is an umlsterm, Signaltransduktion is an umlsterm, Genexpression is an umlsterm, Stressereignisse is an umlsterm, Sepsis is an umlsterm, Therapien is an umlsterm	DerAnaesthesist.60450312.ger.abstr_task0	Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .	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Sepsisbegriff is an umlsterm, Sepsis is an umlsterm, Patienten is an umlsterm, Immunsystems is an umlsterm, Entzuendungsmediatoren is an umlsterm, Toxinen is an umlsterm, Polytrauma is an umlsterm, Pankreatitis is an umlsterm, Monozyten is an umlsterm, Makrophagen is an umlsterm, Monozyten - Makrophagensystems is an umlsterm, Signaltransduktion is an umlsterm, Stressgenexpression is an umlsterm, Signaltransduktion is an umlsterm, Genexpression is an umlsterm, Stressereignisse is an umlsterm, Sepsis is an umlsterm, Therapien is an umlsterm	DerAnaesthesist.60450312.ger.abstr_task1	Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please typing these entity words according to sentence: Sepsisbegriff, Sepsis, Patienten, Immunsystems, Entzuendungsmediatoren, Toxinen, Polytrauma, Pankreatitis, Monozyten, Makrophagen, Monozyten - Makrophagensystems, Signaltransduktion, Stressgenexpression, Signaltransduktion, Genexpression, Stressereignisse, Sepsis, Therapien Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .	[ "Sepsisbegriff", "und", "pathophysiologische", "Konzepte", "der", "Sepsis", "haben", "in", "den", "letzten", "Jahren", "einen", "tiefgreifenden", "Wandel", "erfahren", ".", "Im", "Zentrum", "der", "pathogenetischen", "Vorstellungen", "zur", "Entwicklung", "eines", "septischen", "(", "Mehr-", ")", "Organversagens", "steht", "heute", "die", "Fehlregulation", "potentiell", "protektiver", "Defensivsysteme", "des", "septischen", "Patienten", "im", "Sinne", "einer", "host", "defense", "failure", "disease", "\"", ".", "\"", "Initialer", "Ausloeser", "der", "pathophysiologischen", "Sequenz", "von", "Ereignissen", ",", "die", "letztlich", "zur", "systemischen", "Entzuendungsreaktion", "und", "Organschaedigung", "fuehrt", ",", "scheint", "die", "Aktivierung", "des", "unspezifischen", "Immunsystems", "mit", "exzessiver", "Produktion", "von", "Entzuendungsmediatoren", "zu", "sein", ".", "Neben", "bakteriellen", "Toxinen", "kommen", "auch", "abakterielle", "Insulte", "wie", "Polytrauma", "oder", "Pankreatitis", "als", "Ausloeser", "eines", "vergleichbaren", "Symptomenkomplexes", "mit", "Ueberstimulation", "der", "Monozyten", "und", "Makrophagen", "in", "Frage", ".", "Die", "Aktivierung", "des", "Monozyten", "-", "Makrophagensystems", "scheint", "dabei", "eine", "Facette", "einer", "generalisierten", "Stoerung", "der", "Zell", "-", "Zellkommunikation", "und", "subzellulaerer", "Funktionen", "wie", "Signaltransduktion", "und", "Stressgenexpression", "zu", "sein", ".", "Veraenderungen", "der", "Signaltransduktion", "wie", "der", "Genexpression", "koennen", "die", "Reaktion", "des", "Organismus", "auf", "nachfolgende", "Stressereignisse", "positiv", "wie", "negativ", "beeinflussen", ".", "Dieses", "als", "priming", "\"", "\"", "bezeichnete", "Phaenomen", "beeinflusst", "nach", "heutigem", "Verstaendnis", "wesentlich", "die", "Entwicklung", "eines", "eventuellen", "Organversagens", "(", "\"", "double", "hit", "\"", "-Modell", "der", "Sepsis", ")", ".", "Die", "Diskrepanz", "zwischen", "lokal", "protektiven", "Wirkungen", "und", "systemischen", "Auswirkungen", "einer", "Aktivierung", "der", "Defensivsysteme", "stellt", "ein", "besonderes", "Hindernis", "fuer", "die", "Entwicklung", "antiinflammatorischer", "oder", "immunmodulatorischer", "Therapien", "dar", "." ]	[ "umlsterm" ]
Sepsisbegriff, Sepsis, Patienten, Immunsystems, Entzuendungsmediatoren, Toxinen, Polytrauma, Pankreatitis, Monozyten, Makrophagen, Monozyten - Makrophagensystems, Signaltransduktion, Stressgenexpression, Signaltransduktion, Genexpression, Stressereignisse, Sepsis, Therapien	DerAnaesthesist.60450312.ger.abstr_task2	Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .	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salicilatos is a NORMALIZABLES, azatioprina is a NORMALIZABLES, infliximab is a PROTEINAS, Hb is a PROTEINAS, creatinina is a NORMALIZABLES, reactantes de fase aguda is a PROTEINAS, PCR is a PROTEINAS, salicilatos is a NORMALIZABLES, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES, sodio is a NORMALIZABLES, potasio is a NORMALIZABLES, calcio is a NORMALIZABLES, fósforo is a NORMALIZABLES, LDH is a PROTEINAS, urato is a NORMALIZABLES, ácido úrico is a NORMALIZABLES, alopurinol is a NORMALIZABLES, rasburicasa is a NORMALIZABLES, urato is a NORMALIZABLES, urato is a NORMALIZABLES, cadenas ligeras tipo lamda is a PROTEINAS	304_task0	Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. 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El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.	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salicilatos is a NORMALIZABLES, azatioprina is a NORMALIZABLES, infliximab is a PROTEINAS, Hb is a PROTEINAS, creatinina is a NORMALIZABLES, reactantes de fase aguda is a PROTEINAS, PCR is a PROTEINAS, salicilatos is a NORMALIZABLES, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES, sodio is a NORMALIZABLES, potasio is a NORMALIZABLES, calcio is a NORMALIZABLES, fósforo is a NORMALIZABLES, LDH is a PROTEINAS, urato is a NORMALIZABLES, ácido úrico is a NORMALIZABLES, alopurinol is a NORMALIZABLES, rasburicasa is a NORMALIZABLES, urato is a NORMALIZABLES, urato is a NORMALIZABLES, cadenas ligeras tipo lamda is a PROTEINAS	304_task1	Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. Instructions: please typing these entity words according to sentence: salicilatos, azatioprina, infliximab, Hb, creatinina, reactantes de fase aguda, PCR, salicilatos, urea, creatinina, sodio, potasio, calcio, fósforo, LDH, urato, ácido úrico, alopurinol, rasburicasa, urato, urato, cadenas ligeras tipo lamda Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.	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salicilatos, azatioprina, infliximab, Hb, creatinina, reactantes de fase aguda, PCR, salicilatos, urea, creatinina, sodio, potasio, calcio, fósforo, LDH, urato, ácido úrico, alopurinol, rasburicasa, urato, urato, cadenas ligeras tipo lamda	304_task2	Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. 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El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.	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Behandlung is an umlsterm, Verletzungen is an umlsterm, Wirbelsaeule is an umlsterm, unfallchirurgische is an umlsterm, Deutschland is an umlsterm, Oesterreich is an umlsterm, Wirbelsaeule is an umlsterm, Gesellschaft is an umlsterm, Patienten is an umlsterm, maennlich is an umlsterm, Patienten is an umlsterm, Verletzung is an umlsterm, Wirbelsaeulen- is an umlsterm, Komplikationen is an umlsterm, Behandlung is an umlsterm, Rehabilitation is an umlsterm, Analyse is an umlsterm, Unfallursachen is an umlsterm, Hoehe is an umlsterm, Verkehrsunfaelle is an umlsterm, Lendenwirbelkoerper is an umlsterm, Verletzungen is an umlsterm, Patienten is an umlsterm, Kompressionsverletzungen is an umlsterm, Wirbelsaeulenverletzung is an umlsterm, Extremitaeten is an umlsterm, Thorax is an umlsterm, Patienten is an umlsterm, Verkehrsunfallopfer is an umlsterm, Rotationsverletzung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Laehmung is an umlsterm, Paraplegie is an umlsterm, Patienten is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Wirbelsaeule is an umlsterm, Patienten is an umlsterm, Unfalls is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm, Freizeitaktivitaeten is an umlsterm, Rueckenbeweglichkeit is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Unfall is an umlsterm	DerUnfallchirurg.91020924.ger.abstr_task0	Sentence: Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . 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An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .	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An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . 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An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .	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Behandlung, Verletzungen, Wirbelsaeule, unfallchirurgische, Deutschland, Oesterreich, Wirbelsaeule, Gesellschaft, Patienten, maennlich, Patienten, Verletzung, Wirbelsaeulen-, Komplikationen, Behandlung, Rehabilitation, Analyse, Unfallursachen, Hoehe, Verkehrsunfaelle, Lendenwirbelkoerper, Verletzungen, Patienten, Kompressionsverletzungen, Wirbelsaeulenverletzung, Extremitaeten, Thorax, Patienten, Verkehrsunfallopfer, Rotationsverletzung, Patienten, Patienten, Laehmung, Paraplegie, Patienten, Unfall, Patienten, Wirbelsaeule, Patienten, Unfalls, Arbeit, Patienten, Freizeitaktivitaeten, Rueckenbeweglichkeit, Patienten, Zeit, Unfall	DerUnfallchirurg.91020924.ger.abstr_task2	Sentence: Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . 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An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .	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Mesenchymale is an umlsterm, Tumoren is an umlsterm, Neoplasien is an umlsterm, Lipom is an umlsterm, Dermis is an umlsterm, pleomorphe Lipom is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, Dermis is an umlsterm, Prognose is an umlsterm, Tumoren is an umlsterm, Liposarkom is an umlsterm, Klassifizierung is an umlsterm, Neoplasien is an umlsterm, Biologie is an umlsterm, Tumoren is an umlsterm	DerPathologe.00210441.ger.abstr_task0	Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .	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Mesenchymale is an umlsterm, Tumoren is an umlsterm, Neoplasien is an umlsterm, Lipom is an umlsterm, Dermis is an umlsterm, pleomorphe Lipom is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, Dermis is an umlsterm, Prognose is an umlsterm, Tumoren is an umlsterm, Liposarkom is an umlsterm, Klassifizierung is an umlsterm, Neoplasien is an umlsterm, Biologie is an umlsterm, Tumoren is an umlsterm	DerPathologe.00210441.ger.abstr_task1	Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please typing these entity words according to sentence: Mesenchymale, Tumoren, Neoplasien, Lipom, Dermis, pleomorphe Lipom, Neoplasien, Neoplasien, Dermis, Prognose, Tumoren, Liposarkom, Klassifizierung, Neoplasien, Biologie, Tumoren Options: umlsterm	[ "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .	[ "Mesenchymale", "Tumoren", "lipogener", "Differenzierung", "stellen", "die", "groesste", "Gruppe", "der", "insgesamt", "seltenen", "und", "heterogenen", "Weichgewebstumoren", "dar", ".", "In", "den", "letzten", "Jahren", "sind", "in", "diesem", "Spektrum", "eine", "Reihe", "\"", "neuer", "\"", "Entitaeten", "und", "Formvarianten", "beschrieben", "und", "charakterisiert", "worden", ",", "deren", "Kenntnis", "bei", "der", "richtigen", "klinisch", "-", "prognostischen", "Einordnung", "von", "besonderer", "Bedeutung", "ist", ",", "um", "eine", "eventuelle", "Verwechslung", "mit", "klinisch", "aggressiveren", "bzw", ".", "harmloseren", "Neoplasien", "und", "damit", "eine", "Unter-", "bzw", ".", "Uebertherapie", "zu", "vermeiden", ".", "Zu", "diesen", "Entitaeten", "gehoeren", "das", "chondroide", "Lipom", "und", "das", "Myolipom", "sowie", "das", "auf", "die", "Dermis", "begrenzte", "Spindelzell-", "und", "pleomorphe", "Lipom", ",", "die", "biologisch", "benigne", "Neoplasien", "darstellen", ",", "morphologisch", "aber", "sarkomatoese", "Neoplasien", "imitieren", "koennen", ".", "Auf", "die", "Dermis", "beschraenkte", "Liposarkome", "sind", "trotz", "einer", "teilweise", "hochmalignen", "Morphologie", "durch", "eine", "gute", "klinische", "Prognose", "charakterisiert", ".", "Im", "Spektrum", "der", "atypischen", "lipomatoesen", "Tumoren", "(", "gut", "differenzierte", "Liposarkome", ")", "wurde", "mit", "dem", "gut", "differenzierten", "spindelzelligen", "Liposarkom", "eine", "seltene", "Formvariante", "beschrieben", ",", "die", "von", "metastasierungsfaehigen", "dedifferenzierten", "Liposarkomen", "einerseits", "und", "von", "benignen", "Spindelzelllipomen", "andererseits", "abzugrenzen", "ist", ".", "Darueber", "hinaus", "haben", "umfangreiche", "zytogenetische", "und", "molekularpathologische", "Untersuchungen", "von", "Fettgewebstumoren", "zu", "Modifizierungen", "bei", "der", "Klassifizierung", "lipogener", "Neoplasien", "gefuehrt", "und", "zu", "einem", "besseren", "Verstaendnis", "der", "Biologie", "dieser", "Gruppe", "der", "mesenchymalen", "Tumoren", "beigetragen", "." ]	[ "umlsterm" ]
Mesenchymale, Tumoren, Neoplasien, Lipom, Dermis, pleomorphe Lipom, Neoplasien, Neoplasien, Dermis, Prognose, Tumoren, Liposarkom, Klassifizierung, Neoplasien, Biologie, Tumoren	DerPathologe.00210441.ger.abstr_task2	Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .	[ "Mesenchymale", "Tumoren", "lipogener", "Differenzierung", "stellen", "die", "groesste", "Gruppe", "der", "insgesamt", "seltenen", "und", "heterogenen", "Weichgewebstumoren", "dar", ".", "In", "den", "letzten", "Jahren", "sind", "in", "diesem", "Spektrum", "eine", "Reihe", "\"", "neuer", "\"", "Entitaeten", "und", "Formvarianten", "beschrieben", "und", "charakterisiert", "worden", ",", "deren", "Kenntnis", "bei", "der", "richtigen", "klinisch", "-", "prognostischen", "Einordnung", "von", "besonderer", "Bedeutung", "ist", ",", "um", "eine", "eventuelle", "Verwechslung", "mit", "klinisch", "aggressiveren", "bzw", ".", "harmloseren", "Neoplasien", "und", "damit", "eine", "Unter-", "bzw", ".", "Uebertherapie", "zu", "vermeiden", ".", "Zu", "diesen", "Entitaeten", "gehoeren", "das", "chondroide", "Lipom", "und", "das", "Myolipom", "sowie", "das", "auf", "die", "Dermis", "begrenzte", "Spindelzell-", "und", "pleomorphe", "Lipom", ",", "die", "biologisch", "benigne", "Neoplasien", "darstellen", ",", "morphologisch", "aber", "sarkomatoese", "Neoplasien", "imitieren", "koennen", ".", "Auf", "die", "Dermis", "beschraenkte", "Liposarkome", "sind", "trotz", "einer", "teilweise", "hochmalignen", "Morphologie", "durch", "eine", "gute", "klinische", "Prognose", "charakterisiert", ".", "Im", "Spektrum", "der", "atypischen", "lipomatoesen", "Tumoren", "(", "gut", "differenzierte", "Liposarkome", ")", "wurde", "mit", "dem", "gut", "differenzierten", "spindelzelligen", "Liposarkom", "eine", "seltene", "Formvariante", "beschrieben", ",", "die", "von", "metastasierungsfaehigen", "dedifferenzierten", "Liposarkomen", "einerseits", "und", "von", "benignen", "Spindelzelllipomen", "andererseits", "abzugrenzen", "ist", ".", "Darueber", "hinaus", "haben", "umfangreiche", "zytogenetische", "und", "molekularpathologische", "Untersuchungen", "von", "Fettgewebstumoren", "zu", "Modifizierungen", "bei", "der", "Klassifizierung", "lipogener", "Neoplasien", "gefuehrt", "und", "zu", "einem", "besseren", "Verstaendnis", "der", "Biologie", "dieser", "Gruppe", "der", "mesenchymalen", "Tumoren", "beigetragen", "." ]	[ "umlsterm" ]
dyslipidemia is a Condition, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl is a Scope, Lipid - lowering treatment is a Procedure, stable is a Qualifier, in the last month is a Temporal, LDL - cholesterol is a Measurement, above 100 mg / dl is a Value, in the month prior to inclusion is a Temporal, apnea - hypopnea index is a Measurement, between 5 - 30 h-1 is a Value	NCT02557412_inc_task0	Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Procedure, Scope, Measurement	[ "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O" ]	Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1	[ "Diagnosis", "of", "dyslipidemia", ":", "The", "existence", "of", "a", "previous", "clinical", "diagnostic", "of", "dyslipidemia", "associated", "with", "lipid", "-", "lowering", "therapy", ".", "It", "is", "also", "considered", "patients", "who", "have", "an", "altered", "analytical", ",", "using", "the", "following", "cutoffs", ":", "total", "cholesterol", "=", "200", "mg", "/", "dl", ",", "triglycerides", "=", "180", "mg", "/", "dl", ",", "HDL", "-", "cholesterol", "=", "40", "mg", "/", "dl", "or", "LDL", "-", "cholesterol", "=", "150", "mg", "/", "dl", ".", "Lipid", "-", "lowering", "treatment", "and", "diet", ",", "stable", "in", "the", "last", "month", ".", "\n", "A", "concentration", "of", "LDL", "-", "cholesterol", "above", "100", "mg", "/", "dl", ",", "in", "the", "month", "prior", "to", "inclusion", ".", "\n", "An", "apnea", "-", "hypopnea", "index", "between", "5", "-", "30", "h-1", "\n" ]	[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]
dyslipidemia is a Condition, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl is a Scope, Lipid - lowering treatment is a Procedure, stable is a Qualifier, in the last month is a Temporal, LDL - cholesterol is a Measurement, above 100 mg / dl is a Value, in the month prior to inclusion is a Temporal, apnea - hypopnea index is a Measurement, between 5 - 30 h-1 is a Value	NCT02557412_inc_task1	Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please typing these entity words according to sentence: dyslipidemia, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl, Lipid - lowering treatment, stable, in the last month, LDL - cholesterol, above 100 mg / dl, in the month prior to inclusion, apnea - hypopnea index, between 5 - 30 h-1 Options: Temporal, Condition, Qualifier, Value, Procedure, Scope, Measurement	[ "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O" ]	Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1	[ "Diagnosis", "of", "dyslipidemia", ":", "The", "existence", "of", "a", "previous", "clinical", "diagnostic", "of", "dyslipidemia", "associated", "with", "lipid", "-", "lowering", "therapy", ".", "It", "is", "also", "considered", "patients", "who", "have", "an", "altered", "analytical", ",", "using", "the", "following", "cutoffs", ":", "total", "cholesterol", "=", "200", "mg", "/", "dl", ",", "triglycerides", "=", "180", "mg", "/", "dl", ",", "HDL", "-", "cholesterol", "=", "40", "mg", "/", "dl", "or", "LDL", "-", "cholesterol", "=", "150", "mg", "/", "dl", ".", "Lipid", "-", "lowering", "treatment", "and", "diet", ",", "stable", "in", "the", "last", "month", ".", "\n", "A", "concentration", "of", "LDL", "-", "cholesterol", "above", "100", "mg", "/", "dl", ",", "in", "the", "month", "prior", "to", "inclusion", ".", "\n", "An", "apnea", "-", "hypopnea", "index", "between", "5", "-", "30", "h-1", "\n" ]	[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]
dyslipidemia, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl, Lipid - lowering treatment, stable, in the last month, LDL - cholesterol, above 100 mg / dl, in the month prior to inclusion, apnea - hypopnea index, between 5 - 30 h-1	NCT02557412_inc_task2	Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O" ]	Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1	[ "Diagnosis", "of", "dyslipidemia", ":", "The", "existence", "of", "a", "previous", "clinical", "diagnostic", "of", "dyslipidemia", "associated", "with", "lipid", "-", "lowering", "therapy", ".", "It", "is", "also", "considered", "patients", "who", "have", "an", "altered", "analytical", ",", "using", "the", "following", "cutoffs", ":", "total", "cholesterol", "=", "200", "mg", "/", "dl", ",", "triglycerides", "=", "180", "mg", "/", "dl", ",", "HDL", "-", "cholesterol", "=", "40", "mg", "/", "dl", "or", "LDL", "-", "cholesterol", "=", "150", "mg", "/", "dl", ".", "Lipid", "-", "lowering", "treatment", "and", "diet", ",", "stable", "in", "the", "last", "month", ".", "\n", "A", "concentration", "of", "LDL", "-", "cholesterol", "above", "100", "mg", "/", "dl", ",", "in", "the", "month", "prior", "to", "inclusion", ".", "\n", "An", "apnea", "-", "hypopnea", "index", "between", "5", "-", "30", "h-1", "\n" ]	[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]

gestational age, > = 28 weeks, Systolic blood pressure, > = 160 mm Hg, diastolic blood pressure, > = 110 mm Hg, > = 18, years

NCT01912677_inc_task2

Sentence: Pregnant gestational age >= 28 weeks Systolic blood pressure >=160 mm Hg OR a diastolic blood pressure of >=110 mm Hg measured twice more than 15 minutes apart Able to swallow pills >= 18 years Instructions: please extract entity words from the input sentence

[ "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O" ]

Pregnant gestational age >= 28 weeks Systolic blood pressure >=160 mm Hg OR a diastolic blood pressure of >=110 mm Hg measured twice more than 15 minutes apart Able to swallow pills >= 18 years

[ "Pregnant", "gestational", "age", ">", "=", "28", "weeks", "\n", "Systolic", "blood", "pressure", ">", "=", "160", "mm", "Hg", "OR", "a", "diastolic", "blood", "pressure", "of", ">", "=", "110", "mm", "Hg", "measured", "twice", "more", "than", "15", "minutes", "apart", "\n", "Able", "to", "swallow", "pills", "\n", ">", "=", "18", "years", "\n" ]

[ "Measurement", "Value", "Person" ]

at least 18yrs is a Value, age is a Person, histologically is a Procedure, confirmed is a Value, CLL / SLL or B - cell Non - Hodgkin lymphoma is a Scope, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma is a Scope, Histological is a Procedure, FL is a Condition, Grade is a Measurement, 1 - 3A is a Value, iNHL is a Condition, relapsed or refractory disease is a Scope, iNHL is a Condition, LPL / WM , MZL is a Scope, aNHL is a Condition, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease is a Scope, CLL is a Condition, SLL is a Condition, PTCL is a Condition, CTCL is a Condition, MF / SS is a Scope, BCR and / or BCL2 inhibitors is a Scope, intolerant is a Condition, relapsed / refractory disease is a Scope, afterwards is a Temporal, Prior is a Temporal, treatment is a Procedure, lymphoid malignancy is a Condition, progressive is a Condition, ≥ 1 prior regimen is a Multiplier, min 2 cycles is a Multiplier, antibody conjugate , cytotoxic chemotherapy , or TKI is a Scope, Measureable disease is a Condition, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0 is a Scope, ECOG Score is a Measurement, 0 or 1 is a Value, Hematologic ANC is a Measurement, > 1000 / uL is a Value, platelet is a Measurement, > 75,000 / uL is a Value, Serum creatinine is a Measurement, < 1.5 ULN is a Value, calculated CrCl is a Measurement, > 50 mL / min is a Value, Bilirubin is a Measurement, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ) is a Scope, AST / AST is a Measurement, < 2.5 ULN is a Value

NCT01994382_inc_task0

Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Multiplier, Procedure, Scope, Measurement

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Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN

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[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]

at least 18yrs is a Value, age is a Person, histologically is a Procedure, confirmed is a Value, CLL / SLL or B - cell Non - Hodgkin lymphoma is a Scope, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma is a Scope, Histological is a Procedure, FL is a Condition, Grade is a Measurement, 1 - 3A is a Value, iNHL is a Condition, relapsed or refractory disease is a Scope, iNHL is a Condition, LPL / WM , MZL is a Scope, aNHL is a Condition, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease is a Scope, CLL is a Condition, SLL is a Condition, PTCL is a Condition, CTCL is a Condition, MF / SS is a Scope, BCR and / or BCL2 inhibitors is a Scope, intolerant is a Condition, relapsed / refractory disease is a Scope, afterwards is a Temporal, Prior is a Temporal, treatment is a Procedure, lymphoid malignancy is a Condition, progressive is a Condition, ≥ 1 prior regimen is a Multiplier, min 2 cycles is a Multiplier, antibody conjugate , cytotoxic chemotherapy , or TKI is a Scope, Measureable disease is a Condition, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0 is a Scope, ECOG Score is a Measurement, 0 or 1 is a Value, Hematologic ANC is a Measurement, > 1000 / uL is a Value, platelet is a Measurement, > 75,000 / uL is a Value, Serum creatinine is a Measurement, < 1.5 ULN is a Value, calculated CrCl is a Measurement, > 50 mL / min is a Value, Bilirubin is a Measurement, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ) is a Scope, AST / AST is a Measurement, < 2.5 ULN is a Value

NCT01994382_inc_task1

Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please typing these entity words according to sentence: at least 18yrs, age, histologically, confirmed, CLL / SLL or B - cell Non - Hodgkin lymphoma, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma, Histological, FL, Grade, 1 - 3A, iNHL, relapsed or refractory disease, iNHL, LPL / WM , MZL, aNHL, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease, CLL, SLL, PTCL, CTCL, MF / SS, BCR and / or BCL2 inhibitors, intolerant, relapsed / refractory disease, afterwards, Prior, treatment, lymphoid malignancy, progressive, ≥ 1 prior regimen, min 2 cycles, antibody conjugate , cytotoxic chemotherapy , or TKI, Measureable disease, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0, ECOG Score, 0 or 1, Hematologic ANC, > 1000 / uL, platelet, > 75,000 / uL, Serum creatinine, < 1.5 ULN, calculated CrCl, > 50 mL / min, Bilirubin, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ), AST / AST, < 2.5 ULN Options: Temporal, Condition, Value, Person, Multiplier, Procedure, Scope, Measurement

[ "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Procedure", "B-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "O", "O", "B-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "O", "O", "B-Temporal", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O" ]

Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN

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[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]

at least 18yrs, age, histologically, confirmed, CLL / SLL or B - cell Non - Hodgkin lymphoma, DLBCL , FL , MCL , MZL , lymphoplasmacytic lymphoma, Histological, FL, Grade, 1 - 3A, iNHL, relapsed or refractory disease, iNHL, LPL / WM , MZL, aNHL, DLBCL , FL Grade 3B , MCL , and transformed NHL with relapsed disease, CLL, SLL, PTCL, CTCL, MF / SS, BCR and / or BCL2 inhibitors, intolerant, relapsed / refractory disease, afterwards, Prior, treatment, lymphoid malignancy, progressive, ≥ 1 prior regimen, min 2 cycles, antibody conjugate , cytotoxic chemotherapy , or TKI, Measureable disease, ≥ 1 lesion ≥ 1.5 cm single dimension via CT , CT / PET with nodal or mass lesions ; Quantifiable circulating tumor cells ; or for Waldenström 's macroglobulinemia presence of IgM l > 2X ULN ; For CTCL : mSWAT > 0, ECOG Score, 0 or 1, Hematologic ANC, > 1000 / uL, platelet, > 75,000 / uL, Serum creatinine, < 1.5 ULN, calculated CrCl, > 50 mL / min, Bilirubin, < 20.0mg / dL ( if Gilberts then < 2.5 mg / dL ), AST / AST, < 2.5 ULN

NCT01994382_inc_task2

Sentence: Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN Instructions: please extract entity words from the input sentence

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Phase 1 Specific Patient at least 18yrs of age with histologically confirmed CLL/SLL or B-cell Non-Hodgkin lymphoma (DLBCL, FL, MCL, MZL, lymphoplasmacytic lymphoma). Phase 2a Inclusion Histological evidence: FL Grade 1-3A/iNHL, with relapsed or refractory disease (iNHL includes LPL/WM, MZL); aNHL, defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, PTCL, or CTCL (with MF/SS) with relapsed or refractory. Received BCR and/or BCL2 inhibitors were intolerant or had relapsed/refractory disease afterwards. Prior treatment for lymphoid malignancy for progressive /refractory disease ≥ 1 prior regimen (min 2 cycles) with antibody conjugate, cytotoxic chemotherapy, or TKI alone or in combination. Measureable disease defined as: ≥ 1 lesion ≥ 1.5 cm single dimension via CT, CT/PET with nodal or mass lesions; Quantifiable circulating tumor cells; or for Waldenström's macroglobulinemia presence of IgM l > 2X ULN; For CTCL: mSWAT > 0 Ability to provide diagnostic reports General Inclusion ECOG Score of 0 or 1. Hematologic ANC > 1000/uL and platelet > 75,000/uL, Serum creatinine of < 1.5 ULN or calculated CrCl of > 50 mL/min Bilirubin < 20.0mg/dL (if Gilberts then < 2.5 mg/dL) and AST/AST < 2.5 ULN

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[ "Scope", "Condition", "Measurement", "Procedure", "Drug", "Multiplier", "Value", "Temporal", "Person" ]

Surgical is an umlsterm, metastases is an umlsterm, overall is an umlsterm, survival is an umlsterm, carcinoma is an umlsterm, patients is an umlsterm, survival is an umlsterm, breast is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, lung cancer is an umlsterm, metastases is an umlsterm, breast is an umlsterm, renal cell carcinoma is an umlsterm, Age is an umlsterm, patients is an umlsterm, survival is an umlsterm, surgery is an umlsterm, morbidity is an umlsterm, hospitalization is an umlsterm, time is an umlsterm, patients is an umlsterm, survival is an umlsterm

DerOrthopaede.80270294.eng.abstr_task0

Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .

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[ "umlsterm" ]

Surgical is an umlsterm, metastases is an umlsterm, overall is an umlsterm, survival is an umlsterm, carcinoma is an umlsterm, patients is an umlsterm, survival is an umlsterm, breast is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, lung cancer is an umlsterm, metastases is an umlsterm, breast is an umlsterm, renal cell carcinoma is an umlsterm, Age is an umlsterm, patients is an umlsterm, survival is an umlsterm, surgery is an umlsterm, morbidity is an umlsterm, hospitalization is an umlsterm, time is an umlsterm, patients is an umlsterm, survival is an umlsterm

DerOrthopaede.80270294.eng.abstr_task1

Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please typing these entity words according to sentence: Surgical, metastases, overall, survival, carcinoma, patients, survival, breast, thyroid, carcinoma, lung cancer, metastases, breast, renal cell carcinoma, Age, patients, survival, surgery, morbidity, hospitalization, time, patients, survival Options: umlsterm

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Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .

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[ "umlsterm" ]

Surgical, metastases, overall, survival, carcinoma, patients, survival, breast, thyroid, carcinoma, lung cancer, metastases, breast, renal cell carcinoma, Age, patients, survival, surgery, morbidity, hospitalization, time, patients, survival

DerOrthopaede.80270294.eng.abstr_task2

Sentence: Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival . Instructions: please extract entity words from the input sentence

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Surgical resection of osseous metastases is becoming more and more important in obtaining longer overall survival in carcinoma patients . In 228 cases surgically treated at our institution between 1980 and 1993 , the survival was 49 % after 1 year , 32 % after 2 years , 22 % after 3 years and , finally , 11 % after 5 years . Retrospectively evaluated , breast and thyroid carcinoma proved to be of positive prognostic influence and lung cancer of negative significance . As a main significant parameter , further extraosseous metastases were evaluated . The prognostic influence of the number of osseous lesions could only be demonstrated in breast and renal cell carcinoma without involvement of further organs . Age and location of the skeletal lesions proved to be of no prognostic influence . Based on these prognostic parameters , three subgroups of patients with worse , median and good long-term survival could be defined . In conclusion , the indication and amount of surgery can be based on these prognostic factors , leading to a decrease in morbidity and hospitalization time in patients with limited survival .

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[ "umlsterm" ]

Strahlentherapie is an umlsterm, Tumorbett is an umlsterm, Therapieregimes is an umlsterm, Lokalrezidivrate is an umlsterm, Therapieregimen is an umlsterm, Tumorkontrolle is an umlsterm, Leber- is an umlsterm, Peritonealmetastasen is an umlsterm, Zeit is an umlsterm

DerChirurg.00710682.ger.abstr_task0

Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .

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[ "umlsterm" ]

Strahlentherapie is an umlsterm, Tumorbett is an umlsterm, Therapieregimes is an umlsterm, Lokalrezidivrate is an umlsterm, Therapieregimen is an umlsterm, Tumorkontrolle is an umlsterm, Leber- is an umlsterm, Peritonealmetastasen is an umlsterm, Zeit is an umlsterm

DerChirurg.00710682.ger.abstr_task1

Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please typing these entity words according to sentence: Strahlentherapie, Tumorbett, Therapieregimes, Lokalrezidivrate, Therapieregimen, Tumorkontrolle, Leber-, Peritonealmetastasen, Zeit Options: umlsterm

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Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .

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[ "umlsterm" ]

Strahlentherapie, Tumorbett, Therapieregimes, Lokalrezidivrate, Therapieregimen, Tumorkontrolle, Leber-, Peritonealmetastasen, Zeit

DerChirurg.00710682.ger.abstr_task2

Sentence: Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Durch intraoperative Strahlentherapie ( IORT ) wird unter maximaler Schonung der umliegenden strahlensensiblen Organe die Strahlendosis im Tumorbett lokal erhoeht . Mit diesem Verfahren als Bestandteil eines multimodalen Therapieregimes konnten sowohl die Lokalrezidivrate als auch die Ueberlebensrate gegenueber konventionellen Therapieregimen beim fortgeschrittenen primaeren Rectumcarcinom und Carcinomrezidiv verbessert werden . Dagegen ist bisher nur in wenigen Studien ueber eine verbesserte Ueberlebensrate durch zusaetzliche IORT beim fortgeschrittenen Magencarcinom berichtet worden . Beim Pankreascarcinom wird durch IORT die lokale Tumorkontrolle , nicht aber die Ueberlebensrate verbessert , da haeufig Leber- und Peritonealmetastasen auftreten . Fuer das Oesophaguscarcinom liegen zur Zeit nur unzureichende Daten vor .

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[ "umlsterm" ]

interferon is a Intervention_Pharmacological, response is a Outcome_Physical, alpha - interferon is a Intervention_Pharmacological, anti - human immunodeficiency virus antibody status is a Outcome_Physical, chronic active hepatitis on liver biopsy is a Outcome_Physical, AST level is a Outcome_Physical, hepatitis B virus DNA level is a Outcome_Physical, acute hepatitis is a Outcome_Physical, acute icteric hepatitis is a Outcome_Physical, HBsAg is a Outcome_Physical, HBeAg is a Outcome_Physical

41158_task0

Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical

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Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .

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[ "Outcome_Physical", "Intervention_Pharmacological" ]

interferon is a Intervention_Pharmacological, response is a Outcome_Physical, alpha - interferon is a Intervention_Pharmacological, anti - human immunodeficiency virus antibody status is a Outcome_Physical, chronic active hepatitis on liver biopsy is a Outcome_Physical, AST level is a Outcome_Physical, hepatitis B virus DNA level is a Outcome_Physical, acute hepatitis is a Outcome_Physical, acute icteric hepatitis is a Outcome_Physical, HBsAg is a Outcome_Physical, HBeAg is a Outcome_Physical

41158_task1

Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please typing these entity words according to sentence: interferon, response, alpha - interferon, anti - human immunodeficiency virus antibody status, chronic active hepatitis on liver biopsy, AST level, hepatitis B virus DNA level, acute hepatitis, acute icteric hepatitis, HBsAg, HBeAg Options: Intervention_Pharmacological, Outcome_Physical

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Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .

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[ "Outcome_Physical", "Intervention_Pharmacological" ]

interferon, response, alpha - interferon, anti - human immunodeficiency virus antibody status, chronic active hepatitis on liver biopsy, AST level, hepatitis B virus DNA level, acute hepatitis, acute icteric hepatitis, HBsAg, HBeAg

41158_task2

Sentence: Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) . Instructions: please extract entity words from the input sentence

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Treatment of hepatitis B virus infection with interferon . Factors predicting response to interferon . Several randomised controlled trials have been undertaken to evaluate the efficacy of alpha-interferon in the therapy of chronic hepatitis B . In patients with HBe antigen-positive disease acquired in adult life the response rates vary from 25-50 % . In those infected at birth , response rates are lower . Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection . In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks , a negative anti-human immunodeficiency virus antibody status ( p less than 0.001 ) , chronic active hepatitis on liver biopsy ( p less than 0.005 ) , high AST level ( p less than 0.001 ) , low hepatitis B virus DNA level ( p less than 0.001 ) and a history of acute hepatitis ( p less than 0.005 ) were all associated with an increased likelihood of response on univariate analysis . On stepwise logistic regression analysis , hepatitis B virus DNA , AST and a history of acute hepatitis predicted response independently ( p less than 0.05 ) . The most reliable combination of predictive factors was a negative anti-human immunodeficiency virus antibody status , with either a positive history of acute icteric hepatitis and AST greater than 45 IU per liter or no history of acute icteric hepatitis and AST greater than 85 IU per liter , which predicted response in 77 % with a specificity of 79 % ( p less than 0.001 ) . The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of less than 2 years duration ( p less than 0.001 ) .

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[ "Outcome_Physical", "Intervention_Pharmacological" ]

Cys 23-Ser 23 is a ProteinMutation

1658_task0

Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation

[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.

[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]

[ "ProteinMutation" ]

Cys 23-Ser 23 is a ProteinMutation

1658_task1

Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please typing these entity words according to sentence: Cys 23-Ser 23 Options: ProteinMutation

[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.

[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]

[ "ProteinMutation" ]

Cys 23-Ser 23

1658_task2

Sentence: A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. Instructions: please extract entity words from the input sentence

[ "O", "B-ProteinMutation", "I-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.

[ "A", "Cys", "23-Ser", "23", "substitution", "in", "the", "5-HT(2C", ")", "receptor", "gene", "influences", "body", "weight", "regulation", "in", "females", "with", "seasonal", "affective", "disorder", ":", "an", "Austrian", "-", "Canadian", "collaborative", "study", "." ]

[ "ProteinMutation" ]

Herpes simplex virus is an umlsterm, infections is an umlsterm, cause is an umlsterm, ulcerations is an umlsterm, infections is an umlsterm, HSV-1 is an umlsterm, HSV-2 is an umlsterm, infections is an umlsterm, blood donors is an umlsterm, hospital is an umlsterm, patients is an umlsterm, risk factors is an umlsterm, herpesvirus infections is an umlsterm, STD is an umlsterm, infectious diseases is an umlsterm, immunosuppression is an umlsterm, native is an umlsterm, antigens is an umlsterm, glycoproteins is an umlsterm, Western blot is an umlsterm

Bundesgesundheitsblatt.90420776.eng.abstr_task0

Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .

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[ "umlsterm" ]

Herpes simplex virus is an umlsterm, infections is an umlsterm, cause is an umlsterm, ulcerations is an umlsterm, infections is an umlsterm, HSV-1 is an umlsterm, HSV-2 is an umlsterm, infections is an umlsterm, blood donors is an umlsterm, hospital is an umlsterm, patients is an umlsterm, risk factors is an umlsterm, herpesvirus infections is an umlsterm, STD is an umlsterm, infectious diseases is an umlsterm, immunosuppression is an umlsterm, native is an umlsterm, antigens is an umlsterm, glycoproteins is an umlsterm, Western blot is an umlsterm

Bundesgesundheitsblatt.90420776.eng.abstr_task1

Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please typing these entity words according to sentence: Herpes simplex virus, infections, cause, ulcerations, infections, HSV-1, HSV-2, infections, blood donors, hospital, patients, risk factors, herpesvirus infections, STD, infectious diseases, immunosuppression, native, antigens, glycoproteins, Western blot Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .

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[ "umlsterm" ]

Herpes simplex virus, infections, cause, ulcerations, infections, HSV-1, HSV-2, infections, blood donors, hospital, patients, risk factors, herpesvirus infections, STD, infectious diseases, immunosuppression, native, antigens, glycoproteins, Western blot

Bundesgesundheitsblatt.90420776.eng.abstr_task2

Sentence: Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Herpes simplex virus type 1 ( HSV-1) and type 2 ( HSV-2) are the most frequent infections cause of genital ulcerations . Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections . This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors ( 1979 samples ) and hospital patients ( 3079 samples ) without risk factors for herpesvirus infections such as STD , other infectious diseases and immunosuppression . Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins . Equivocal results were confirmed with an in-house Western blot .

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[ "umlsterm" ]

p. E300X is a ProteinMutation

432_task0

Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]

Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.

[ "Focal", "dermal", "hypoplasia", "resulting", "from", "a", "new", "nonsense", "mutation", ",", "p.", "E300X", ",", "in", "the", "PORCN", "gene", "." ]

[ "DNAMutation", "ProteinMutation" ]

p. E300X is a ProteinMutation

432_task1

Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please typing these entity words according to sentence: p. E300X Options: ProteinMutation

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]

Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.

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[ "DNAMutation", "ProteinMutation" ]

p. E300X

432_task2

Sentence: Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "I-ProteinMutation", "O", "O", "O", "O", "O", "O" ]

Focal dermal hypoplasia resulting from a new nonsense mutation, p.E300X, in the PORCN gene.

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[ "DNAMutation", "ProteinMutation" ]

fixation of fractures is an umlsterm, bones is an umlsterm, method is an umlsterm, fracture is an umlsterm, bone is an umlsterm, fracture is an umlsterm, children is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, femur is an umlsterm, technique is an umlsterm, intramedullary nailing is an umlsterm, humerus is an umlsterm, hospital is an umlsterm, immobilisation is an umlsterm, patients is an umlsterm, operation is an umlsterm, hospital is an umlsterm, patients is an umlsterm, fractures is an umlsterm, operation is an umlsterm, intramedullary nails is an umlsterm, time is an umlsterm, weight is an umlsterm, legs is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, movements is an umlsterm, operation is an umlsterm, technique is an umlsterm, risks is an umlsterm, trauma is an umlsterm, early mobilisation is an umlsterm, literature is an umlsterm, nails is an umlsterm, skin is an umlsterm

DerUnfallchirurg.01030002.eng.abstr_task0

Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .

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[ "umlsterm" ]

fixation of fractures is an umlsterm, bones is an umlsterm, method is an umlsterm, fracture is an umlsterm, bone is an umlsterm, fracture is an umlsterm, children is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, femur is an umlsterm, technique is an umlsterm, intramedullary nailing is an umlsterm, humerus is an umlsterm, hospital is an umlsterm, immobilisation is an umlsterm, patients is an umlsterm, operation is an umlsterm, hospital is an umlsterm, patients is an umlsterm, fractures is an umlsterm, operation is an umlsterm, intramedullary nails is an umlsterm, time is an umlsterm, weight is an umlsterm, legs is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, movements is an umlsterm, operation is an umlsterm, technique is an umlsterm, risks is an umlsterm, trauma is an umlsterm, early mobilisation is an umlsterm, literature is an umlsterm, nails is an umlsterm, skin is an umlsterm

DerUnfallchirurg.01030002.eng.abstr_task1

Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please typing these entity words according to sentence: fixation of fractures, bones, method, fracture, bone, fracture, children, fractures, humerus, femur, technique, intramedullary nailing, humerus, hospital, immobilisation, patients, operation, hospital, patients, fractures, operation, intramedullary nails, time, weight, legs, fractures, humerus, movements, operation, technique, risks, trauma, early mobilisation, literature, nails, skin Options: umlsterm

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The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .

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[ "umlsterm" ]

fixation of fractures, bones, method, fracture, bone, fracture, children, fractures, humerus, femur, technique, intramedullary nailing, humerus, hospital, immobilisation, patients, operation, hospital, patients, fractures, operation, intramedullary nails, time, weight, legs, fractures, humerus, movements, operation, technique, risks, trauma, early mobilisation, literature, nails, skin

DerUnfallchirurg.01030002.eng.abstr_task2

Sentence: The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin . Instructions: please extract entity words from the input sentence

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The internal fixation of fractures of shaft bones was spread out by a group of surgeons working together with Prevot . The principle of this method is a three point load carrying ( entry point , height of fracture and cancellous bone of the metaphysis of the opposite fracture part ) . From 1996 to 1999 86 children with fractures of the humerus , the fore-arm and the femur were operated in the technique of intramedullary nailing . The fractures affected the humerus to 3.5 % , the fore-arm to 65.1 % and the femoral shaft to 31.4 % . The postoperativ duration of stay in hospital after internal fixation of the fore-arm in the proximal and middle third lasted 7.2 days , the duration of immobilisation in a cast took 13.7 days . 96 % of the patients showed very good and good results after operation . The average stay in hospital for patients with femoral shaft fractures was 14.4 days . 17 weeks after operation the intramedullary nails were removed . At the time of first full weight bearing the legs showed an average shortening of 1.2 cm . The fractures of the humerus healed without any restriction of movements . Internal fixation is a minimal invasive operation technique with low risks and small operating trauma . Due to the stability a early mobilisation is possible . The reported results in the literature are all good . The only problem can be caused by too long nails irritating the skin .

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[ "umlsterm" ]

Patricia is a NOMBRE_SUJETO_ASISTENCIA, Montero Iglesias is a NOMBRE_SUJETO_ASISTENCIA, 3467890 is a ID_SUJETO_ASISTENCIA, 89 56734809 36 is a ID_ASEGURAMIENTO, Vigo is a TERRITORIO, 36201 is a TERRITORIO, 04/7/1940 is a FECHAS, España is a PAIS, 76 años is a EDAD_SUJETO_ASISTENCIA, 03/06/2017 is a FECHAS, 7348563 is a ID_CONTACTO_ASISTENCIAL, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36 28 57410 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 76 años is a EDAD_SUJETO_ASISTENCIA, 1992 is a FECHAS, año 2000 is a FECHAS, 2002 is a FECHAS, agosto de 2005 is a FECHAS, 25 de agosto is a FECHAS, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36201 is a TERRITORIO, Vigo is a TERRITORIO, ngomez@povisa.es is a CORREO_ELECTRONICO

164_task0

Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es

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Patricia is a NOMBRE_SUJETO_ASISTENCIA, Montero Iglesias is a NOMBRE_SUJETO_ASISTENCIA, 3467890 is a ID_SUJETO_ASISTENCIA, 89 56734809 36 is a ID_ASEGURAMIENTO, Vigo is a TERRITORIO, 36201 is a TERRITORIO, 04/7/1940 is a FECHAS, España is a PAIS, 76 años is a EDAD_SUJETO_ASISTENCIA, 03/06/2017 is a FECHAS, 7348563 is a ID_CONTACTO_ASISTENCIAL, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36 28 57410 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 76 años is a EDAD_SUJETO_ASISTENCIA, 1992 is a FECHAS, año 2000 is a FECHAS, 2002 is a FECHAS, agosto de 2005 is a FECHAS, 25 de agosto is a FECHAS, Nora Gómez Rodríguez is a NOMBRE_PERSONAL_SANITARIO, 36201 is a TERRITORIO, Vigo is a TERRITORIO, ngomez@povisa.es is a CORREO_ELECTRONICO

164_task1

Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es Instructions: please typing these entity words according to sentence: Patricia, Montero Iglesias, 3467890, 89 56734809 36, Vigo, 36201, 04/7/1940, España, 76 años, 03/06/2017, 7348563, Nora Gómez Rodríguez, 36 28 57410, Mujer, 76 años, 1992, año 2000, 2002, agosto de 2005, 25 de agosto, Nora Gómez Rodríguez, 36201, Vigo, ngomez@povisa.es Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es

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[ "CALLE", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "NOMBRE_SUJETO_ASISTENCIA", "FECHAS", "ID_ASEGURAMIENTO", "ID_TITULACION_PERSONAL_SANITARIO", "EDAD_SUJETO_ASISTENCIA", "ID_CONTACTO_ASISTENCIAL", "ID_SUJETO_ASISTENCIA", "PAIS", "TERRITORIO", "SEXO_SUJETO_ASISTENCIA" ]

Patricia, Montero Iglesias, 3467890, 89 56734809 36, Vigo, 36201, 04/7/1940, España, 76 años, 03/06/2017, 7348563, Nora Gómez Rodríguez, 36 28 57410, Mujer, 76 años, 1992, año 2000, 2002, agosto de 2005, 25 de agosto, Nora Gómez Rodríguez, 36201, Vigo, ngomez@povisa.es

164_task2

Sentence: Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es Instructions: please extract entity words from the input sentence

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Datos del paciente. Nombre: Patricia. Apellidos: Montero Iglesias. NHC: 3467890. NASS: 89 56734809 36. Domicilio: Plaza de Almuñécar, 7, 4 C. Localidad/ Provincia: Vigo. CP: 36201. Datos asistenciales. Fecha de nacimiento: 04/7/1940. País de nacimiento: España. Edad: 76 años Sexo: M. Fecha de Ingreso: 03/06/2017. Servicio: Reumatología. Episodio: 7348563. Médico: Nora Gómez Rodríguez NºCol: 36 28 57410. Informe clínico del paciente: Mujer de 76 años con antecedentes de cardiopatía isquémica, diagnosticada de artritis reumatoide seronegativa en 1992 por una poliartritis crónica, simétrica y erosiva que cumplió cinco de los criterios del American College of Rheumatology. Como medicación de fondo se había utilizado cloroquina y metotrexato parenteral. En el año 2000 fue sometida a una artroplastia total de rodilla derecha con resultado satisfactorio. En 2002 desarrolló una anemia normocítica, fatigabilidad, una neuropatía periférica sensitivomotora y esplenomegalia. El estudio hematológico reveló un componente monoclonal de IgM de 3,1 g/dl y tras una biopsia de médula ósea fue diagnosticada de macroglobulinemia de Waldenström. Debido a que la enferma se mantuvo estable y oligosintomática con bajas dosis de prednisona (7,5 mg/día) y metrotrexato oral (7,5 mg/semana) el servicio de hematología optó por mantener una actitud expectante, difiriendo la terapia con agentes alquilantes o análogos de nucleósidos. Durante los tres primeros días de agosto de 2005 presentó una diarrea febril autolimitada. Tras una mejoría de una semana, comenzó con febrícula, dolor, tumefacción y progresiva limitación de la movilidad en la rodilla derecha, síntomas que persistieron y que motivaron la consulta e ingreso en nuestro centro el 25 de agosto. Exploración física: En la exploración destacaba una temperatura axilar de 37,5 ºC, tumefacción y derrame a tensión en la rodilla derecha, hipoestesia parcheada en las extremidades inferiores y abolición de los reflejos aquíleos. Pruebas complementarias: La artrocentesis dio salida a un fluido purulento de color crema con 75.000 leucocitos/mm3 (> 95% polimorfonucleares). La tinción de Gram no permitió visualizar microorganismos, pero en los cultivos aeróbicos se recuperó L. monocytogenes sensible a penicilina, ampicilina, cotrimoxazol y rifampicina. La VSG fue de 120 mm/1ª hora. Proteína C reactiva: 51,7 mg/L. El hemograma mostró 6,5 x 109 leucocitos/L (47% neutrófilos, 25% linfocitos, 14% monocitos), Hb: 99 g/L, hematocrito: 28,7 L/L, plaquetas: 442 x 109/L. Dosificación de inmuglobulinas: IgA (25 mg/dl), IgG (405 mg/dl), IgM (2.300 mg/dl; VN < 230); cadenas ligeras: lambda (44 mg/dl; VN: 90-210), kappa (276 mg/dl; VN 170-370). Los siguientes parámetros fueron normales o negativos: bioquímica (glucosa, creatinina, urea, colesterol total, triglicéridos, lácticodehidrogenasa, creatinincinasa, transaminasas, bilirrubina, fosfatasa alcalina, gammaglutamiltranspeptidasa, calcio, fósforo, sodio, potasio y cloro), análisis de orina, serología para Salmonella, Shigella y Yersinia, dosificación del complemento (C3 y C4) y anticuerpos antinucleares. El factor reumatoide por látex fue 54 UI / ml. La radiografía de tórax no mostró alteraciones. La radiografía de la rodilla derecha permitió observar radiolucencias periprotésicas. En la ecografía abdominal se halló signos de esteatosis hepática y discreta esplenomegalia. Además de drenaje y lavado de la articulación con suero fisiológico se administraron por vía intravenosa 2 g de ampicilina cada 6 h y gentamicina (3 mg/kg/8 horas; manteniendo una concentración entre 4 y 9 mg/ml) durante 5 semanas. Evolución: En el momento de redactar esta nota clínica han transcurrido tres meses desde el alta hospitalaria, la paciente evoluciona favorablemente y recibe tratamiento con cotrimoxazol y rifampicina, que se prolongará hasta completar un total de 6 meses. Responsable clínico: Dra. Nora Gómez Rodríguez Unidad de Reumatología. C/ Colón, 28-1º. 36201 Vigo. e-mail: ngomez@povisa.es

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Metformin is a CHEMICAL, phenformin is a CHEMICAL, AMP - activated protein kinase is a GENE-N, AMP is a CHEMICAL

17369473_task0

Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL

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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

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Metformin is a CHEMICAL, phenformin is a CHEMICAL, AMP - activated protein kinase is a GENE-N, AMP is a CHEMICAL

17369473_task1

Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please typing these entity words according to sentence: Metformin, phenformin, AMP - activated protein kinase, AMP Options: GENE-N, CHEMICAL

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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

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[ "GENE-N", "CHEMICAL" ]

Metformin, phenformin, AMP - activated protein kinase, AMP

17369473_task2

Sentence: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Instructions: please extract entity words from the input sentence

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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

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[ "GENE-N", "CHEMICAL" ]

glutathione is a compound, glutathione peroxidase is a protein, superoxide dismutase is a protein, catalase is a protein

DS.d509_task0

Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

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In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.

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[ "protein", "compound" ]

glutathione is a compound, glutathione peroxidase is a protein, superoxide dismutase is a protein, catalase is a protein

DS.d509_task1

Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please typing these entity words according to sentence: glutathione, glutathione peroxidase, superoxide dismutase, catalase Options: compound, protein

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In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.

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[ "protein", "compound" ]

glutathione, glutathione peroxidase, superoxide dismutase, catalase

DS.d509_task2

Sentence: In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed. Instructions: please extract entity words from the input sentence

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In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.

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magnetic resonance spectroscopy is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, measurement is an umlsterm, phosphates is an umlsterm, phospholipids is an umlsterm, human is an umlsterm, brain is an umlsterm, patients is an umlsterm, controls is an umlsterm, review is an umlsterm, survey is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, comments is an umlsterm, phospholipids is an umlsterm, patients is an umlsterm, membrane is an umlsterm, phospholipid is an umlsterm, neuroleptic is an umlsterm, medication is an umlsterm

DerNervenarzt.00710354.eng.abstr_task0

Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .

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magnetic resonance spectroscopy is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, measurement is an umlsterm, phosphates is an umlsterm, phospholipids is an umlsterm, human is an umlsterm, brain is an umlsterm, patients is an umlsterm, controls is an umlsterm, review is an umlsterm, survey is an umlsterm, schizophrenia is an umlsterm, research is an umlsterm, comments is an umlsterm, phospholipids is an umlsterm, patients is an umlsterm, membrane is an umlsterm, phospholipid is an umlsterm, neuroleptic is an umlsterm, medication is an umlsterm

DerNervenarzt.00710354.eng.abstr_task1

Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please typing these entity words according to sentence: magnetic resonance spectroscopy, schizophrenia, research, measurement, phosphates, phospholipids, human, brain, patients, controls, review, survey, schizophrenia, research, comments, phospholipids, patients, membrane, phospholipid, neuroleptic, medication Options: umlsterm

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31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .

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[ "umlsterm" ]

magnetic resonance spectroscopy, schizophrenia, research, measurement, phosphates, phospholipids, human, brain, patients, controls, review, survey, schizophrenia, research, comments, phospholipids, patients, membrane, phospholipid, neuroleptic, medication

DerNervenarzt.00710354.eng.abstr_task2

Sentence: 31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication . Instructions: please extract entity words from the input sentence

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31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication .

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[ "umlsterm" ]

heart rate is an umlsterm, Methods is an umlsterm, fractal is an umlsterm, method is an umlsterm, behavior is an umlsterm, techniques is an umlsterm, analysis is an umlsterm, monitor is an umlsterm, Instruments is an umlsterm, time is an umlsterm, analysis is an umlsterm, time is an umlsterm, axis is an umlsterm, reproduction is an umlsterm, behavior is an umlsterm, period is an umlsterm, behavior is an umlsterm, heart rate is an umlsterm, method is an umlsterm, time is an umlsterm

Herzschrittmachertherapie.80090212.eng.abstr_task0

Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .

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[ "umlsterm" ]

heart rate is an umlsterm, Methods is an umlsterm, fractal is an umlsterm, method is an umlsterm, behavior is an umlsterm, techniques is an umlsterm, analysis is an umlsterm, monitor is an umlsterm, Instruments is an umlsterm, time is an umlsterm, analysis is an umlsterm, time is an umlsterm, axis is an umlsterm, reproduction is an umlsterm, behavior is an umlsterm, period is an umlsterm, behavior is an umlsterm, heart rate is an umlsterm, method is an umlsterm, time is an umlsterm

Herzschrittmachertherapie.80090212.eng.abstr_task1

Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please typing these entity words according to sentence: heart rate, Methods, fractal, method, behavior, techniques, analysis, monitor, Instruments, time, analysis, time, axis, reproduction, behavior, period, behavior, heart rate, method, time Options: umlsterm

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The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .

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[ "umlsterm" ]

heart rate, Methods, fractal, method, behavior, techniques, analysis, monitor, Instruments, time, analysis, time, axis, reproduction, behavior, period, behavior, heart rate, method, time

Herzschrittmachertherapie.80090212.eng.abstr_task2

Sentence: The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects . Instructions: please extract entity words from the input sentence

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The description of heart rate variability ( HRV ) by statistical and spectral parameters is a problem not yet satisfactorally solved . Methods of the fractal geometry might provide some advantages because not only the length of RR-intervals ( RRI ) but the information derived from the order of RRI is considered . This method is expected to allow differentiation between chance and deterministic chaotic behavior . Hence , we developed techniques for the description of HRV by means of dimension analysis . The course of information dimension ( ID ) over 24h in 20 healthy probands was estimated from a digital holter monitor recording ( sampling rate 1000Hz , holter recorder FD3 Oxford Instruments ) . For that we calculated ID from a time window of 2500 RRI for the embedding dimension 2 up to 6. The analysis window was subsequently moved forward along a time axis in steps of 1000 RRI . The graphical reproduction of ID courses over 24h showed irregularly alternating phases of chance and deterministic chaotic behavior during the day . Conversely during the night two different patterns were demonstrated : either a persistant phase of increased chance or a period of deterministic chaotic behavior predominated . A significant correlation neither with heart rate nor with other collected or calculated data could be shown . Our method is able to asses ID over time as well as with increasing embedding dimensions . So beside statistical and spectral parameters there is a further new tool for HRV description available . Following studies have to elucidate clinical aspects .

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[ "umlsterm" ]

human spermidine / spermine N1-acetyltransferase is a GENE-Y

16455797_task0

Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

[ "Structures", "of", "wild", "-", "type", "and", "mutant", "human", "spermidine", "/", "spermine", "N1-acetyltransferase", ",", "a", "potential", "therapeutic", "drug", "target", "." ]

[ "GENE-Y", "CHEMICAL" ]

human spermidine / spermine N1-acetyltransferase is a GENE-Y

16455797_task1

Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please typing these entity words according to sentence: human spermidine / spermine N1-acetyltransferase Options: GENE-Y

[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

[ "Structures", "of", "wild", "-", "type", "and", "mutant", "human", "spermidine", "/", "spermine", "N1-acetyltransferase", ",", "a", "potential", "therapeutic", "drug", "target", "." ]

[ "GENE-Y", "CHEMICAL" ]

human spermidine / spermine N1-acetyltransferase

16455797_task2

Sentence: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O" ]

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

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[ "GENE-Y", "CHEMICAL" ]

Glutamate Receptor is a GENE-N

23590882_task0

Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.

[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]

[ "GENE-N", "CHEMICAL" ]

Glutamate Receptor is a GENE-N

23590882_task1

Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please typing these entity words according to sentence: Glutamate Receptor Options: GENE-N

[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.

[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]

[ "GENE-N", "CHEMICAL" ]

Glutamate Receptor

23590882_task2

Sentence: Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis. Instructions: please extract entity words from the input sentence

[ "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis.

[ "Interacting", "Glutamate", "Receptor", "-", "Like", "Proteins", "in", "Phloem", "Regulate", "Lateral", "Root", "Initiation", "in", "Arabidopsis", "." ]

[ "GENE-N", "CHEMICAL" ]

Effects of surfactant is a Outcome_Other, biofilm formation is a Outcome_Physical, silicone nasal splints . is a Outcome_Physical, Biofilms is a Intervention_Pharmacological, biofilm formation . is a Outcome_Physical, Forty patients is a Participant_Sample-size, septoplasty is a Intervention_Surgical, surfactant - containing saline solution ( group is a Intervention_Pharmacological, saline without surfactant is a Intervention_Pharmacological, scanning electron microscopic evaluation is a Outcome_Other, Biofilm formation is a Outcome_Physical, Surfactant - containing nasal solutions is a Intervention_Pharmacological, nasal septal dressing is a Outcome_Physical

65763_task0

Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical

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Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .

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[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]

Effects of surfactant is a Outcome_Other, biofilm formation is a Outcome_Physical, silicone nasal splints . is a Outcome_Physical, Biofilms is a Intervention_Pharmacological, biofilm formation . is a Outcome_Physical, Forty patients is a Participant_Sample-size, septoplasty is a Intervention_Surgical, surfactant - containing saline solution ( group is a Intervention_Pharmacological, saline without surfactant is a Intervention_Pharmacological, scanning electron microscopic evaluation is a Outcome_Other, Biofilm formation is a Outcome_Physical, Surfactant - containing nasal solutions is a Intervention_Pharmacological, nasal septal dressing is a Outcome_Physical

65763_task1

Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please typing these entity words according to sentence: Effects of surfactant, biofilm formation, silicone nasal splints ., Biofilms, biofilm formation ., Forty patients, septoplasty, surfactant - containing saline solution ( group, saline without surfactant, scanning electron microscopic evaluation, Biofilm formation, Surfactant - containing nasal solutions, nasal septal dressing Options: Intervention_Pharmacological, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical

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Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .

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[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]

Effects of surfactant, biofilm formation, silicone nasal splints ., Biofilms, biofilm formation ., Forty patients, septoplasty, surfactant - containing saline solution ( group, saline without surfactant, scanning electron microscopic evaluation, Biofilm formation, Surfactant - containing nasal solutions, nasal septal dressing

65763_task2

Sentence: Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future . Instructions: please extract entity words from the input sentence

[ "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]

Effects of surfactant on biofilm formation on silicone nasal splints . Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans . Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation . The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints . Forty patients were randomized after septoplasty to receive surfactant-containing saline solution ( group 1 ) or saline without surfactant ( group 2 ) . At the postoperative 48th , 72th and 96th hours , pieces of splint samples were taken and prepared for scanning electron microscopic evaluation . Biofilm formation was observed in 3 , 6 and 14 of 20 samples in group 1 ( surfactant used ) and 3 , 14 and 20 of 20 samples in group 2 ( control ) at 48th , 72th and 96th hours , respectively . Biofilm formation incidences of groups at 48th hour were similar ( p > 0.05 ) , whereas it was significantly lower at group 1 regarding 72th and 96th hours ( p < 0.05 ) . Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future .

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[ "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Intervention_Physical", "Participant_Sample-size", "Intervention_Surgical", "Participant_Condition" ]

alcohol dehydrogenase is a protein, ADH is a protein, G6PDH is a protein, ethyl-3-oxobutanoate is a compound, EOB is a compound, S)-3-hydroxybutanoate is a compound

DS.d1676_task0

Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.

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[ "protein", "compound" ]

alcohol dehydrogenase is a protein, ADH is a protein, G6PDH is a protein, ethyl-3-oxobutanoate is a compound, EOB is a compound, S)-3-hydroxybutanoate is a compound

DS.d1676_task1

Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please typing these entity words according to sentence: alcohol dehydrogenase, ADH, G6PDH, ethyl-3-oxobutanoate, EOB, S)-3-hydroxybutanoate Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.

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[ "protein", "compound" ]

alcohol dehydrogenase, ADH, G6PDH, ethyl-3-oxobutanoate, EOB, S)-3-hydroxybutanoate

DS.d1676_task2

Sentence: The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.

[ "The", "effects", "of", "industrial", "storage", "on", "the", "changes", "of", "the", "cell", "viability", "and", "the", "activities", "of", "intracellular", "alcohol", "dehydrogenase", "(", "ADH", ")", "and", "glucose-6-phosphate", "dehydrogenase", "(", "G6PDH", ")", "in", "brewer", "'s", "yeast", ",", "and", "the", "corresponding", "capacity", "for", "the", "bioconversion", "of", "ethyl-3-oxobutanoate", "(", "EOB", ")", "to", "ethyl", "(", "S)-3-hydroxybutanoate", "(", "(", "S)-EHB", ")", ",", "were", "investigated", "." ]

[ "protein", "compound" ]

Age is a Person, = 18 years is a Value, American Society of Anesthesiologists Classification is a Observation, I - III is a Value, Normal is a Value, cognitive function is a Measurement, Agreement to the trial protocol is a Observation

NCT03372265_inc_task0

Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Person, Measurement, Observation, Value

[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]

Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner

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[ "Observation", "Measurement", "Value", "Person" ]

Age is a Person, = 18 years is a Value, American Society of Anesthesiologists Classification is a Observation, I - III is a Value, Normal is a Value, cognitive function is a Measurement, Agreement to the trial protocol is a Observation

NCT03372265_inc_task1

Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please typing these entity words according to sentence: Age, = 18 years, American Society of Anesthesiologists Classification, I - III, Normal, cognitive function, Agreement to the trial protocol Options: Person, Measurement, Observation, Value

[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]

Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner

[ "Age", "=", "18", "years", "\n", "American", "Society", "of", "Anesthesiologists", "Classification", "I", "-", "III", "\n", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "\n", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner", "\n" ]

[ "Observation", "Measurement", "Value", "Person" ]

Age, = 18 years, American Society of Anesthesiologists Classification, I - III, Normal, cognitive function, Agreement to the trial protocol

NCT03372265_inc_task2

Sentence: Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner Instructions: please extract entity words from the input sentence

[ "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O" ]

Age = 18 years American Society of Anesthesiologists Classification I-III Normal cognitive function in order to sign written, informed consent and to understand trial protocol Agreement to the trial protocol, including the randomized manner

[ "Age", "=", "18", "years", "\n", "American", "Society", "of", "Anesthesiologists", "Classification", "I", "-", "III", "\n", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "\n", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner", "\n" ]

[ "Observation", "Measurement", "Value", "Person" ]

relative is an umlsterm, thrombolytic is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, thrombus is an umlsterm, clinical studies is an umlsterm, case reports is an umlsterm, patients is an umlsterm, therapy is an umlsterm, recommendations is an umlsterm, choice is an umlsterm, therapy is an umlsterm, therapy is an umlsterm, contraindications is an umlsterm, literature review is an umlsterm

IntensiveMedizin.80350620.eng.abstr_task0

Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .

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[ "umlsterm" ]

relative is an umlsterm, thrombolytic is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, thrombus is an umlsterm, clinical studies is an umlsterm, case reports is an umlsterm, patients is an umlsterm, therapy is an umlsterm, recommendations is an umlsterm, choice is an umlsterm, therapy is an umlsterm, therapy is an umlsterm, contraindications is an umlsterm, literature review is an umlsterm

IntensiveMedizin.80350620.eng.abstr_task1

Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please typing these entity words according to sentence: relative, thrombolytic, surgical, therapy, thrombus, clinical studies, case reports, patients, therapy, recommendations, choice, therapy, therapy, contraindications, literature review Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .

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[ "umlsterm" ]

relative, thrombolytic, surgical, therapy, thrombus, clinical studies, case reports, patients, therapy, recommendations, choice, therapy, therapy, contraindications, literature review

IntensiveMedizin.80350620.eng.abstr_task2

Sentence: The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The relative success of thrombolytic versus surgical therapy of thrombus in transit has not yet been evaluated in clinical studies . Only case reports of one or more patients exist . Optimal therapy , therefore , remains controversial , and conclusive recommendations in favor of one choice of therapy over the other cannot be given . Nevertheless , in current practice thrombolysis as a noninvasive and quickly available form of therapy is preferred , if no contraindications exist . Two cases are presented together with a literature review .

[ "The", "relative", "success", "of", "thrombolytic", "versus", "surgical", "therapy", "of", "thrombus", "in", "transit", "has", "not", "yet", "been", "evaluated", "in", "clinical", "studies", ".", "Only", "case", "reports", "of", "one", "or", "more", "patients", "exist", ".", "Optimal", "therapy", ",", "therefore", ",", "remains", "controversial", ",", "and", "conclusive", "recommendations", "in", "favor", "of", "one", "choice", "of", "therapy", "over", "the", "other", "cannot", "be", "given", ".", "Nevertheless", ",", "in", "current", "practice", "thrombolysis", "as", "a", "noninvasive", "and", "quickly", "available", "form", "of", "therapy", "is", "preferred", ",", "if", "no", "contraindications", "exist", ".", "Two", "cases", "are", "presented", "together", "with", "a", "literature", "review", "." ]

[ "umlsterm" ]

Schleudertrauma is an umlsterm, Diagnosen is an umlsterm, Verkehrsunfaellen is an umlsterm, bildgebende Diagnostik is an umlsterm, Diagnostik is an umlsterm

ManuelleMedizin.90370079.ger.abstr_task0

Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .

[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]

[ "umlsterm" ]

Schleudertrauma is an umlsterm, Diagnosen is an umlsterm, Verkehrsunfaellen is an umlsterm, bildgebende Diagnostik is an umlsterm, Diagnostik is an umlsterm

ManuelleMedizin.90370079.ger.abstr_task1

Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please typing these entity words according to sentence: Schleudertrauma, Diagnosen, Verkehrsunfaellen, bildgebende Diagnostik, Diagnostik Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .

[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]

[ "umlsterm" ]

Schleudertrauma, Diagnosen, Verkehrsunfaellen, bildgebende Diagnostik, Diagnostik

ManuelleMedizin.90370079.ger.abstr_task2

Sentence: Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Das Schleudertrauma der HWS ist eine der haeufigsten Diagnosen nach Verkehrsunfaellen . Grundsaetzlich wird hierbei eine bildgebende Diagnostik durchgefuehrt , die sich in den meisten Faellen auf die konventionelle Diagnostik beschraenkt .

[ "Das", "Schleudertrauma", "der", "HWS", "ist", "eine", "der", "haeufigsten", "Diagnosen", "nach", "Verkehrsunfaellen", ".", "Grundsaetzlich", "wird", "hierbei", "eine", "bildgebende", "Diagnostik", "durchgefuehrt", ",", "die", "sich", "in", "den", "meisten", "Faellen", "auf", "die", "konventionelle", "Diagnostik", "beschraenkt", "." ]

[ "umlsterm" ]

survey is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, disease is an umlsterm, anal fissure is an umlsterm, therapies is an umlsterm, hospital is an umlsterm, therapeutic is an umlsterm, surgery is an umlsterm, choice is an umlsterm, operative procedure is an umlsterm, Future is an umlsterm, research is an umlsterm, standardization is an umlsterm, therapy is an umlsterm, disorders is an umlsterm

DerChirurg.80690215.eng.abstr_task0

Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .

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[ "umlsterm" ]

survey is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, disease is an umlsterm, anal fissure is an umlsterm, therapies is an umlsterm, hospital is an umlsterm, therapeutic is an umlsterm, surgery is an umlsterm, choice is an umlsterm, operative procedure is an umlsterm, Future is an umlsterm, research is an umlsterm, standardization is an umlsterm, therapy is an umlsterm, disorders is an umlsterm

DerChirurg.80690215.eng.abstr_task1

Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please typing these entity words according to sentence: survey, therapeutic, treatment, disease, anal fissure, therapies, hospital, therapeutic, surgery, choice, operative procedure, Future, research, standardization, therapy, disorders Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .

[ "A", "survey", "among", "coloproctologists", "was", "performed", "to", "assess", "current", "therapeutic", "concepts", "for", "the", "treatment", "of", "hemorrhoidal", "disease", "and", "anal", "fissure", ".", "A", "total", "of", "261", "clinical", "and", "non", "-", "clinical", "proctologists", "participated", ",", "representing", "the", "entire", "range", "of", "therapies", "in", "hospital", "and", "practise", ".", "A", "wealth", "of", "widely", "differing", ",", "in", "some", "aspects", "contradictory", "concepts", "were", "recorded", ",", "leaving", "almost", "no", "subject", "entirely", "undisputed", ".", "There", "are", "controversies", "regarding", "the", "different", "therapeutic", "alternatives", "as", "well", "as", "indications", "for", "surgery", "and", "choice", "of", "operative", "procedure", ".", "Future", "research", "has", "to", "address", "the", "existing", "controversies", "in", "order", "to", "reach", "a", "higher", "degree", "of", "standardization", "in", "the", "therapy", "of", "these", "common", "proctological", "disorders", "." ]

[ "umlsterm" ]

survey, therapeutic, treatment, disease, anal fissure, therapies, hospital, therapeutic, surgery, choice, operative procedure, Future, research, standardization, therapy, disorders

DerChirurg.80690215.eng.abstr_task2

Sentence: A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

A survey among coloproctologists was performed to assess current therapeutic concepts for the treatment of hemorrhoidal disease and anal fissure . A total of 261 clinical and non-clinical proctologists participated , representing the entire range of therapies in hospital and practise . A wealth of widely differing , in some aspects contradictory concepts were recorded , leaving almost no subject entirely undisputed . There are controversies regarding the different therapeutic alternatives as well as indications for surgery and choice of operative procedure . Future research has to address the existing controversies in order to reach a higher degree of standardization in the therapy of these common proctological disorders .

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[ "umlsterm" ]

Morbidity is an umlsterm, mortality is an umlsterm, procedure is an umlsterm, sigmoid is an umlsterm, diverticulitis is an umlsterm, procedure is an umlsterm, procedure is an umlsterm, patient is an umlsterm, Method is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, All is an umlsterm, patients is an umlsterm, surgery is an umlsterm, procedure is an umlsterm, patients is an umlsterm, patient is an umlsterm, technique is an umlsterm, technique is an umlsterm, patients is an umlsterm, time is an umlsterm, wound infections is an umlsterm, postoperative complications is an umlsterm, Patients is an umlsterm, convalescence is an umlsterm, surgery is an umlsterm, nutrition is an umlsterm, surgery is an umlsterm, postoperative is an umlsterm, hospitalisation is an umlsterm, patient is an umlsterm, dilatation is an umlsterm, Postoperative is an umlsterm, morbidity is an umlsterm, hospitalisation is an umlsterm, convalescence is an umlsterm, procedures is an umlsterm

DerChirurg.90701139.eng.abstr_task0

Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .

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[ "umlsterm" ]

Morbidity is an umlsterm, mortality is an umlsterm, procedure is an umlsterm, sigmoid is an umlsterm, diverticulitis is an umlsterm, procedure is an umlsterm, procedure is an umlsterm, patient is an umlsterm, Method is an umlsterm, patients is an umlsterm, postoperative is an umlsterm, All is an umlsterm, patients is an umlsterm, surgery is an umlsterm, procedure is an umlsterm, patients is an umlsterm, patient is an umlsterm, technique is an umlsterm, technique is an umlsterm, patients is an umlsterm, time is an umlsterm, wound infections is an umlsterm, postoperative complications is an umlsterm, Patients is an umlsterm, convalescence is an umlsterm, surgery is an umlsterm, nutrition is an umlsterm, surgery is an umlsterm, postoperative is an umlsterm, hospitalisation is an umlsterm, patient is an umlsterm, dilatation is an umlsterm, Postoperative is an umlsterm, morbidity is an umlsterm, hospitalisation is an umlsterm, convalescence is an umlsterm, procedures is an umlsterm

DerChirurg.90701139.eng.abstr_task1

Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . Instructions: please typing these entity words according to sentence: Morbidity, mortality, procedure, sigmoid, diverticulitis, procedure, procedure, patient, Method, patients, postoperative, All, patients, surgery, procedure, patients, patient, technique, technique, patients, time, wound infections, postoperative complications, Patients, convalescence, surgery, nutrition, surgery, postoperative, hospitalisation, patient, dilatation, Postoperative, morbidity, hospitalisation, convalescence, procedures Options: umlsterm

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Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .

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[ "umlsterm" ]

Morbidity, mortality, procedure, sigmoid, diverticulitis, procedure, procedure, patient, Method, patients, postoperative, All, patients, surgery, procedure, patients, patient, technique, technique, patients, time, wound infections, postoperative complications, Patients, convalescence, surgery, nutrition, surgery, postoperative, hospitalisation, patient, dilatation, Postoperative, morbidity, hospitalisation, convalescence, procedures

DerChirurg.90701139.eng.abstr_task2

Sentence: Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically . Instructions: please extract entity words from the input sentence

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Morbidity and mortality after reversal of Hartmann's procedure following perforated sigmoid diverticulitis are high and the rate of intestinal restoration is low . Aim : To investigate whether laparoscopically assisted reversal of Hartmann's procedure is technically feasible and whether the laparoscopic procedure offers any benefit to the patient . Method : Nineteen patients were investigated . The postoperative course was followed prospectively . All patients were reinvestigated 9 months after surgery . Results : Laparoscopic reversal of Hartmann's procedure was attempted in 19 patients . One patient did not want the laparoscopic technique . In two cases ( 11 % ) conversion to the conventional technique was necessary ; thus , 16 patients were operated laparoscopically . Median operative time was 114 ( 65-180 ) min . With the exception of three wound infections no immediate postoperative complications were noticed . Patients ' convalescence was fast . First evacuation took place 3.3 ( 3-5 ) days after surgery , complete oral nutrition 3.6 ( 3-5 ) days after surgery . Duration of postoperative hospitalisation was 7.5 ( 5-12 ) days . One patient developed later a clinically significant anastomotic stricture which needed endoscopic dilatation . Conclusion : Laparoscopically assisted Hartmann's reversal is technically demanding but feasible . Postoperative morbidity is low , duration of hospitalisation short , convalescence fast . Thus , good arguments exist for performing reversal of Hartmann's procedures laparoscopically .

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[ "umlsterm" ]

Patricia is a NOMBRE_SUJETO_ASISTENCIA, Rojo Martinez is a NOMBRE_SUJETO_ASISTENCIA, 56 41365424 10 is a ID_ASEGURAMIENTO, Rúa Salvador Dalí , 2 is a CALLE, Ourense is a TERRITORIO, 32002 is a TERRITORIO, 74513689 is a ID_SUJETO_ASISTENCIA, 30/03/19 is a FECHAS, España is a PAIS, 60 años is a EDAD_SUJETO_ASISTENCIA, 04/09/2017 is a FECHAS, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, 32 28 16479 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 60 años is a EDAD_SUJETO_ASISTENCIA, María Teresa Fernández López is a NOMBRE_PERSONAL_SANITARIO, Complexo Hospitalario Universitario de Ourense is a HOSPITAL, 32002 is a TERRITORIO, Ourense is a TERRITORIO, España is a PAIS, maria.teresa.fernandez.lopez@sergas.es is a CORREO_ELECTRONICO

147_task0

Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es

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147_task1

Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please typing these entity words according to sentence: Patricia, Rojo Martinez, 56 41365424 10, Rúa Salvador Dalí , 2, Ourense, 32002, 74513689, 30/03/19, España, 60 años, 04/09/2017, María Teresa Fernández López, 32 28 16479, Mujer, 60 años, María Teresa Fernández López, Complexo Hospitalario Universitario de Ourense, 32002, Ourense, España, maria.teresa.fernandez.lopez@sergas.es Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es

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[ "HOSPITAL", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "CALLE", "ID_ASEGURAMIENTO", "NOMBRE_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "ID_SUJETO_ASISTENCIA", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]

Patricia, Rojo Martinez, 56 41365424 10, Rúa Salvador Dalí , 2, Ourense, 32002, 74513689, 30/03/19, España, 60 años, 04/09/2017, María Teresa Fernández López, 32 28 16479, Mujer, 60 años, María Teresa Fernández López, Complexo Hospitalario Universitario de Ourense, 32002, Ourense, España, maria.teresa.fernandez.lopez@sergas.es

147_task2

Sentence: Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es Instructions: please extract entity words from the input sentence

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Nombre: Patricia. Apellidos: Rojo Martinez. NASS: 56 41365424 10. Domicilio: Rúa Salvador Dalí, 2 . Localidad/ Provincia: Ourense. CP: 32002. NHC: 74513689. Datos asistenciales. Fecha de nacimiento: 30/03/19. País: España. Edad: 60 años Sexo: M. Fecha de Ingreso: 04/09/2017. Especialidad:Endocrinología. Médico: María Teresa Fernández López NºCol: 32 28 16479. Historia Actual: Mujer de 60 años diagnosticada de neoplasia gástrica antral estenosante. Se realizó una gastrectomía subtotal con reconstrucción en Y de Roux. En el día +7 la paciente se deterioró de forma brusca con aparición de datos de peritonitis, por lo que se sometió a laparotomía urgente, observándose necrosis de curvatura menor gástrica y de cara anterior de esófago distal. Se practicó transección y cierre de esófago abdominal y muñón gástrico, exclusión esofágica con esofagostomía cervical y se colocó yeyunostomía de alimentación, iniciándose NE en el día +1. La paciente fue dada de alta con NED por yeyunostomía. A los tres meses reingresó para reconstruir el tránsito digestivo, previa realización de colonoscopia y tomografía axial computerizada en las que no se objetivaron datos sugestivos de recidiva tumoral. Durante la cirugía se observaron múltiples micronódulos a nivel de colon transverso y en la región correspondiente al epiplon gastrohepático, con anatomía patológica intraoperatoria compatible con células en anillo de sello, por lo que se suspendió la reconstrucción y se mantuvo NED por yeyunostomía de forma indefinida. Remitido por: María Teresa Fernández López. Médico Adjunto del Servicio de Endocrinología y Nutrición. Complexo Hospitalario Universitario de Ourense. C/ Villa Valencia, 20-6o A. 32002 Ourense. España. E-mail: maria.teresa.fernandez.lopez@sergas.es

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Ernaehrung is an umlsterm, Sport is an umlsterm, Rehabilitation is an umlsterm, muskelzellulaeren is an umlsterm, Kohlenhydrate is an umlsterm, Fettsaeuren is an umlsterm, Proteine is an umlsterm, gezielte is an umlsterm, Sportlerernaehrung is an umlsterm, sportspezifische is an umlsterm, Belastung is an umlsterm, muskelzellulaeren is an umlsterm, Stress is an umlsterm, Kreatinkinase is an umlsterm, Myoglobin is an umlsterm, Belastung is an umlsterm, Zytokine is an umlsterm, Interleukin is an umlsterm, Akutphase - proteine is an umlsterm, Fibrinogen is an umlsterm, Stresshormons is an umlsterm, Cortisol is an umlsterm, Belastung is an umlsterm, Mineralstoffen is an umlsterm, Magnesium is an umlsterm, Vitaminen A is an umlsterm, -Carotin is an umlsterm, sportinduzierten is an umlsterm, Muskel- is an umlsterm, Sporttreibenden is an umlsterm, Belastung is an umlsterm

DerOrthopaede.70260942.ger.abstr_task0

Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .

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[ "umlsterm" ]

Ernaehrung is an umlsterm, Sport is an umlsterm, Rehabilitation is an umlsterm, muskelzellulaeren is an umlsterm, Kohlenhydrate is an umlsterm, Fettsaeuren is an umlsterm, Proteine is an umlsterm, gezielte is an umlsterm, Sportlerernaehrung is an umlsterm, sportspezifische is an umlsterm, Belastung is an umlsterm, muskelzellulaeren is an umlsterm, Stress is an umlsterm, Kreatinkinase is an umlsterm, Myoglobin is an umlsterm, Belastung is an umlsterm, Zytokine is an umlsterm, Interleukin is an umlsterm, Akutphase - proteine is an umlsterm, Fibrinogen is an umlsterm, Stresshormons is an umlsterm, Cortisol is an umlsterm, Belastung is an umlsterm, Mineralstoffen is an umlsterm, Magnesium is an umlsterm, Vitaminen A is an umlsterm, -Carotin is an umlsterm, sportinduzierten is an umlsterm, Muskel- is an umlsterm, Sporttreibenden is an umlsterm, Belastung is an umlsterm

DerOrthopaede.70260942.ger.abstr_task1

Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please typing these entity words according to sentence: Ernaehrung, Sport, Rehabilitation, muskelzellulaeren, Kohlenhydrate, Fettsaeuren, Proteine, gezielte, Sportlerernaehrung, sportspezifische, Belastung, muskelzellulaeren, Stress, Kreatinkinase, Myoglobin, Belastung, Zytokine, Interleukin, Akutphase - proteine, Fibrinogen, Stresshormons, Cortisol, Belastung, Mineralstoffen, Magnesium, Vitaminen A, -Carotin, sportinduzierten, Muskel-, Sporttreibenden, Belastung Options: umlsterm

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Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .

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[ "umlsterm" ]

Ernaehrung, Sport, Rehabilitation, muskelzellulaeren, Kohlenhydrate, Fettsaeuren, Proteine, gezielte, Sportlerernaehrung, sportspezifische, Belastung, muskelzellulaeren, Stress, Kreatinkinase, Myoglobin, Belastung, Zytokine, Interleukin, Akutphase - proteine, Fibrinogen, Stresshormons, Cortisol, Belastung, Mineralstoffen, Magnesium, Vitaminen A, -Carotin, sportinduzierten, Muskel-, Sporttreibenden, Belastung

DerOrthopaede.70260942.ger.abstr_task2

Sentence: Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert . Instructions: please extract entity words from the input sentence

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Die Betrachtung des Themenkomplexes Ernaehrung und Sport wird heute weniger in Verbindung mit einer moeglichen Leistungsverbesserung , sondern in zunehmenden Masse unter dem Aspekt der Praevention und Rehabilitation von systemischen und muskelzellulaeren Ueberlastungsphaenomenen gesehen . Unter Beruecksichtigung der Thematik dieser Ausgabe wird im folgenden Text daher nicht auf die Bedeutung der Naehrstoffe Kohlenhydrate , Fettsaeuren und Proteine als Energielieferanten eingegangen , sondern die gezielte Sportlerernaehrung unter dem Gesichtspunkt der Beeinflussung der Belastungsreaktion des trainierenden Organismus betrachtet . Die sportspezifische Belastung spiegelt sich in erhoehtem muskelzellulaeren Stress , messbar vor allem ueber einen Anstieg von Kreatinkinase und Myoglobin im Serum sowie in einer systemischen ( ca. 1-48 h nach Belastung ) immunologischen hormonellen und Akutphase-reaktion , wider . Insbesondere der Verlauf der Zytokine ( vor allem Interleukin 6 ) , der Akutphase-proteine CRP und Fibrinogen und des Stresshormons Cortisol geben Hinweise auf die Belastungsintensitaet bzw. die individuelle Verarbeitung der koerperlichen Belastung . Forschungsergebnisse weisen vor allem den Mineralstoffen Magnesium und Zink , den Vitaminen A , C , E und -Carotin sowie der Zusammensetzung der Nahrungsfettsaeuren eine wesentliche Bedeutung bei der Verminderung der sportinduzierten Muskel- und Ganzkoerperbelastungsreaktion zu . Im der vorliegenden Uebersicht wird daher auf die Bedeutung dieser Naehrstoffe bei intensiv Sporttreibenden - unter besonderer Beruecksichtigung eines vermehrten Verlustes oder Bedarfs waehrend oder nach koerperlicher Belastung - eingegangen und moegliche Auswirkungen eines Defizits diskutiert .

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[ "umlsterm" ]

recommendations is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, coronary heart disease is an umlsterm, Society is an umlsterm, Cardiology is an umlsterm, Atherosclerosis is an umlsterm, Society is an umlsterm, Society is an umlsterm, Hypertension is an umlsterm, objective is an umlsterm, Secondary is an umlsterm, Prevention is an umlsterm, recommendations is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, Germany is an umlsterm, Methods is an umlsterm, patients is an umlsterm, medical records is an umlsterm, hospital is an umlsterm, patients is an umlsterm, coronary artery bypass is an umlsterm, graft is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, myocardial infarction is an umlsterm, myocardial ischemia is an umlsterm, patients is an umlsterm, goal is an umlsterm, patients is an umlsterm, interview is an umlsterm, hospital is an umlsterm, discharge is an umlsterm, patients is an umlsterm, interview is an umlsterm, evaluation is an umlsterm, risk is an umlsterm, interview is an umlsterm, patients is an umlsterm, obese is an umlsterm, blood pressure is an umlsterm, Risk factor is an umlsterm, time is an umlsterm, patients is an umlsterm, values is an umlsterm, risk factors is an umlsterm, time is an umlsterm, interview is an umlsterm, goals is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, treatment is an umlsterm, patients is an umlsterm, secondary is an umlsterm, prevention is an umlsterm

ZfuerKardiologie.70860284.eng.abstr_task0

Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .

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ZfuerKardiologie.70860284.eng.abstr_task1

Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please typing these entity words according to sentence: recommendations, secondary, prevention, coronary heart disease, Society, Cardiology, Atherosclerosis, Society, Society, Hypertension, objective, Secondary, Prevention, recommendations, risk factor, patients, Germany, Methods, patients, medical records, hospital, patients, coronary artery bypass, graft, angioplasty, PTCA, myocardial infarction, myocardial ischemia, patients, goal, patients, interview, hospital, discharge, patients, interview, evaluation, risk, interview, patients, obese, blood pressure, Risk factor, time, patients, values, risk factors, time, interview, goals, secondary, prevention, treatment, patients, secondary, prevention Options: umlsterm

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New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .

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[ "umlsterm" ]

recommendations, secondary, prevention, coronary heart disease, Society, Cardiology, Atherosclerosis, Society, Society, Hypertension, objective, Secondary, Prevention, recommendations, risk factor, patients, Germany, Methods, patients, medical records, hospital, patients, coronary artery bypass, graft, angioplasty, PTCA, myocardial infarction, myocardial ischemia, patients, goal, patients, interview, hospital, discharge, patients, interview, evaluation, risk, interview, patients, obese, blood pressure, Risk factor, time, patients, values, risk factors, time, interview, goals, secondary, prevention, treatment, patients, secondary, prevention

ZfuerKardiologie.70860284.eng.abstr_task2

Sentence: New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice . Instructions: please extract entity words from the input sentence

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New recommendations for secondary prevention of coronary heart disease ( CHD ) were issued by the European Society of Cardiology ( ESC ) , the European Atherosclerosis Society ( EAS ) and the European Society of Hypertension ( ESH ) in 1994. The main objective of the EUROASPIRE study ( European Action on Secondary Prevention by Intervention to Reduce Events ) was to evaluate to what degree the new recommendations have been implemented and whether a significant risk factor reduction in patients who presented with CHD has been achieved . The present study was conducted in the region of Muenster , Westphalia , Germany , as part of the nine-country EUROASPIRE study . Methods : A total of 524 patients ( 58.6 + 8.2 years ) were included in the study by abstracting data from their medical records . According to the clinical event which led to admission to the hospital , patients belonged to the following four groups : 1 ) coronary artery bypass graft ( CABG ) , 2 ) percutaneous transluminal coronary angioplasty ( PTCA ) , 3 ) acute myocardial infarction , 4 ) acute myocardial ischemia . Initially , a pre-specified number of patients had been recruited with the goal of having 100 patients in each of the four groups participate in the follow-up interview and examination . At least 6 months and , on average , 20 months after hospital discharge for the acute event , 74.8% of the patients came to an interview and examination for an evaluation of their risk profile . Results : At the interview , 15.6% of the patients smoked , 22.7% were obese , 54.6% had blood pressure levels above 14090 mm Hg and 31.3% a total cholesterolHDL-cholesterol-ratio greater than 5. Risk factor modification over time was insufficient as only one-fifth of patients had values of their risk factors within the target range at the time of the interview . Conclusion : The goals of secondary prevention have not been achieved in the region of Muenster - there is clearly room for improvement . Considering the treatment of patients with CHD , the recommended strategies of secondary prevention need to be applied more intensively in clinical practice .

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[ "umlsterm" ]

hinteren Schaedelgrube is an umlsterm, Halswirbelsaeule is an umlsterm, Praxis is an umlsterm

DerAnaesthesist.00490269.ger.abstr_task0

Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .

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[ "umlsterm" ]

hinteren Schaedelgrube is an umlsterm, Halswirbelsaeule is an umlsterm, Praxis is an umlsterm

DerAnaesthesist.00490269.ger.abstr_task1

Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please typing these entity words according to sentence: hinteren Schaedelgrube, Halswirbelsaeule, Praxis Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .

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[ "umlsterm" ]

hinteren Schaedelgrube, Halswirbelsaeule, Praxis

DerAnaesthesist.00490269.ger.abstr_task2

Sentence: In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen . Instructions: please extract entity words from the input sentence

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In einer 1998 durchgefuehrten Umfrage wurde der aktuelle Stand bezueglich Lagerung und Monitoring bei neurochirurgischen Eingriffen in der hinteren Schaedelgrube , des kraniospinalen Uebergangs und des dorsalen Zugangs zur oberen Halswirbelsaeule erhoben , um zum einen die Umsetzung bzw. Akzeptanz der 1995 veroeffentlichten Empfehlungen des Arbeitskreises Neuroanaesthesie der DGAI zum Monitoring bei diesen Operationen in der klinischen Praxis zu ueberpruefen und um zum anderen den Einsatz der sitzenden Position sowie alternativer Lagerungstechniken in einem 3-Jahres-Intervall vergleichen zu koennen .

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[ "umlsterm" ]

Pruritus is an umlsterm, Epiphora is an umlsterm, Histaminwirkungen is an umlsterm, Histamingehalts is an umlsterm, Histaminfreisetzung is an umlsterm

DerOpthalmologe.80950241.ger.abstr_task0

Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .

[ "Die", "vorherrschenden", "Symptome", "der", "Conjunctivitis", "allergica", "(", "Typ", "-", "I", "-", "Allergie", "Pruritus", "und", "Epiphora", ",", ")", ",", "sind", "den", "klinisch", "fassbaren", "Histaminwirkungen", "zuzurechnen", ".", "Messungen", "des", "Histamingehalts", "der", "Traenenfluessigkeit", "sollten", "Aufklaerung", "ueber", "die", "Dynamik", "dieser", "lokalen", "Histaminfreisetzung", "in", "Verbindung", "mit", "der", "klinischen", "Symptomatik", "bringen", "." ]

[ "umlsterm" ]

Pruritus is an umlsterm, Epiphora is an umlsterm, Histaminwirkungen is an umlsterm, Histamingehalts is an umlsterm, Histaminfreisetzung is an umlsterm

DerOpthalmologe.80950241.ger.abstr_task1

Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please typing these entity words according to sentence: Pruritus, Epiphora, Histaminwirkungen, Histamingehalts, Histaminfreisetzung Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .

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[ "umlsterm" ]

Pruritus, Epiphora, Histaminwirkungen, Histamingehalts, Histaminfreisetzung

DerOpthalmologe.80950241.ger.abstr_task2

Sentence: Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorherrschenden Symptome der Conjunctivitis allergica ( Typ-I-Allergie Pruritus und Epiphora , ) , sind den klinisch fassbaren Histaminwirkungen zuzurechnen . Messungen des Histamingehalts der Traenenfluessigkeit sollten Aufklaerung ueber die Dynamik dieser lokalen Histaminfreisetzung in Verbindung mit der klinischen Symptomatik bringen .

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[ "umlsterm" ]

Ekzems is an umlsterm, Basistherapie is an umlsterm, Therapie is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapie is an umlsterm, therapieresistenten is an umlsterm, Therapie is an umlsterm, Antihistaminika is an umlsterm, mikrobiellen Superinfektionen is an umlsterm, Antibiotika is an umlsterm, Aciclovir is an umlsterm, Azathioprin is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapieansaetze is an umlsterm

DerHautarzt.90500323.ger.abstr_task0

Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .

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[ "umlsterm" ]

Ekzems is an umlsterm, Basistherapie is an umlsterm, Therapie is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapie is an umlsterm, therapieresistenten is an umlsterm, Therapie is an umlsterm, Antihistaminika is an umlsterm, mikrobiellen Superinfektionen is an umlsterm, Antibiotika is an umlsterm, Aciclovir is an umlsterm, Azathioprin is an umlsterm, Behandlung is an umlsterm, Ekzems is an umlsterm, Therapieansaetze is an umlsterm

DerHautarzt.90500323.ger.abstr_task1

Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please typing these entity words according to sentence: Ekzems, Basistherapie, Therapie, Behandlung, Ekzems, Therapie, therapieresistenten, Therapie, Antihistaminika, mikrobiellen Superinfektionen, Antibiotika, Aciclovir, Azathioprin, Behandlung, Ekzems, Therapieansaetze Options: umlsterm

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Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .

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[ "umlsterm" ]

Ekzems, Basistherapie, Therapie, Behandlung, Ekzems, Therapie, therapieresistenten, Therapie, Antihistaminika, mikrobiellen Superinfektionen, Antibiotika, Aciclovir, Azathioprin, Behandlung, Ekzems, Therapieansaetze

DerHautarzt.90500323.ger.abstr_task2

Sentence: Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten . Instructions: please extract entity words from the input sentence

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Das Behandlungskonzept des atopischen Ekzems beinhaltet die kontinuierliche topische dermatologische Basistherapie in Kombination mit einer zeitlich begrenzten Exazerbations-gerichteten antiinflammatorischen Therapie . In der Behandlung des exazerbierten atopischen Ekzems werden vielfach Systemtherapeutika eingesetzt , um ein rasches und wirkungsvolles Ansprechen der topischen Therapie zu unterstuetzen oder bei therapieresistenten Verlaeufen eine Remission zu erzielen . Neben der adjuvanten Therapie mit Antihistaminika kommen bei mikrobiellen Superinfektionen orale Antibiotika und Aciclovir zum Einsatz . Einer Exazerbation kann vielfach phototherapeutisch , insbesondere durch eine UVA1-Behandlung, erfolgreich entgegnet werden . Auf den Einsatz von systemischen Immuntherapeutika wie Glukokortikosteroiden , Ciclosporin oder Azathioprin kann in der Regel bei der Behandlung des atopischen Ekzems verzichtet werden bzw. stellt nur in wenigen Ausnahmefaellen eine therapeutische Alternative dar . Es gibt vielversprechende neue experimentelle Therapieansaetze , die zukuenftige Behandlungsalternativen darstellen koennten .

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[ "umlsterm" ]

Sepsisbegriff is an umlsterm, Sepsis is an umlsterm, Patienten is an umlsterm, Immunsystems is an umlsterm, Entzuendungsmediatoren is an umlsterm, Toxinen is an umlsterm, Polytrauma is an umlsterm, Pankreatitis is an umlsterm, Monozyten is an umlsterm, Makrophagen is an umlsterm, Monozyten - Makrophagensystems is an umlsterm, Signaltransduktion is an umlsterm, Stressgenexpression is an umlsterm, Signaltransduktion is an umlsterm, Genexpression is an umlsterm, Stressereignisse is an umlsterm, Sepsis is an umlsterm, Therapien is an umlsterm

DerAnaesthesist.60450312.ger.abstr_task0

Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .

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[ "umlsterm" ]

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DerAnaesthesist.60450312.ger.abstr_task1

Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please typing these entity words according to sentence: Sepsisbegriff, Sepsis, Patienten, Immunsystems, Entzuendungsmediatoren, Toxinen, Polytrauma, Pankreatitis, Monozyten, Makrophagen, Monozyten - Makrophagensystems, Signaltransduktion, Stressgenexpression, Signaltransduktion, Genexpression, Stressereignisse, Sepsis, Therapien Options: umlsterm

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Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .

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[ "umlsterm" ]

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DerAnaesthesist.60450312.ger.abstr_task2

Sentence: Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar . Instructions: please extract entity words from the input sentence

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Sepsisbegriff und pathophysiologische Konzepte der Sepsis haben in den letzten Jahren einen tiefgreifenden Wandel erfahren . Im Zentrum der pathogenetischen Vorstellungen zur Entwicklung eines septischen ( Mehr- ) Organversagens steht heute die Fehlregulation potentiell protektiver Defensivsysteme des septischen Patienten im Sinne einer host defense failure disease " . " Initialer Ausloeser der pathophysiologischen Sequenz von Ereignissen , die letztlich zur systemischen Entzuendungsreaktion und Organschaedigung fuehrt , scheint die Aktivierung des unspezifischen Immunsystems mit exzessiver Produktion von Entzuendungsmediatoren zu sein . Neben bakteriellen Toxinen kommen auch abakterielle Insulte wie Polytrauma oder Pankreatitis als Ausloeser eines vergleichbaren Symptomenkomplexes mit Ueberstimulation der Monozyten und Makrophagen in Frage . Die Aktivierung des Monozyten-Makrophagensystems scheint dabei eine Facette einer generalisierten Stoerung der Zell-Zellkommunikation und subzellulaerer Funktionen wie Signaltransduktion und Stressgenexpression zu sein . Veraenderungen der Signaltransduktion wie der Genexpression koennen die Reaktion des Organismus auf nachfolgende Stressereignisse positiv wie negativ beeinflussen . Dieses als priming " " bezeichnete Phaenomen beeinflusst nach heutigem Verstaendnis wesentlich die Entwicklung eines eventuellen Organversagens ( " double hit " -Modell der Sepsis ) . Die Diskrepanz zwischen lokal protektiven Wirkungen und systemischen Auswirkungen einer Aktivierung der Defensivsysteme stellt ein besonderes Hindernis fuer die Entwicklung antiinflammatorischer oder immunmodulatorischer Therapien dar .

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[ "umlsterm" ]

salicilatos is a NORMALIZABLES, azatioprina is a NORMALIZABLES, infliximab is a PROTEINAS, Hb is a PROTEINAS, creatinina is a NORMALIZABLES, reactantes de fase aguda is a PROTEINAS, PCR is a PROTEINAS, salicilatos is a NORMALIZABLES, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES, sodio is a NORMALIZABLES, potasio is a NORMALIZABLES, calcio is a NORMALIZABLES, fósforo is a NORMALIZABLES, LDH is a PROTEINAS, urato is a NORMALIZABLES, ácido úrico is a NORMALIZABLES, alopurinol is a NORMALIZABLES, rasburicasa is a NORMALIZABLES, urato is a NORMALIZABLES, urato is a NORMALIZABLES, cadenas ligeras tipo lamda is a PROTEINAS

304_task0

Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS

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Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.

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[ "PROTEINAS", "NORMALIZABLES" ]

salicilatos is a NORMALIZABLES, azatioprina is a NORMALIZABLES, infliximab is a PROTEINAS, Hb is a PROTEINAS, creatinina is a NORMALIZABLES, reactantes de fase aguda is a PROTEINAS, PCR is a PROTEINAS, salicilatos is a NORMALIZABLES, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES, sodio is a NORMALIZABLES, potasio is a NORMALIZABLES, calcio is a NORMALIZABLES, fósforo is a NORMALIZABLES, LDH is a PROTEINAS, urato is a NORMALIZABLES, ácido úrico is a NORMALIZABLES, alopurinol is a NORMALIZABLES, rasburicasa is a NORMALIZABLES, urato is a NORMALIZABLES, urato is a NORMALIZABLES, cadenas ligeras tipo lamda is a PROTEINAS

304_task1

Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. Instructions: please typing these entity words according to sentence: salicilatos, azatioprina, infliximab, Hb, creatinina, reactantes de fase aguda, PCR, salicilatos, urea, creatinina, sodio, potasio, calcio, fósforo, LDH, urato, ácido úrico, alopurinol, rasburicasa, urato, urato, cadenas ligeras tipo lamda Options: NORMALIZABLES, PROTEINAS

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Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.

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[ "PROTEINAS", "NORMALIZABLES" ]

salicilatos, azatioprina, infliximab, Hb, creatinina, reactantes de fase aguda, PCR, salicilatos, urea, creatinina, sodio, potasio, calcio, fósforo, LDH, urato, ácido úrico, alopurinol, rasburicasa, urato, urato, cadenas ligeras tipo lamda

304_task2

Sentence: Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea. Instructions: please extract entity words from the input sentence

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Varón de 50 años, diagnosticado de enfermedad de Crohn con afectación ileal y perianal compleja en tratamiento inmunosupresor, que acudió a Urgencias por fiebre, supuración perianal y diarrea de 1 semana de evolución. El enfermo mantenía terapia con salicilatos y azatioprina (2,5 mg/kg/día, ajustada según niveles de TPMT) desde hacía 2 años y había recibido 6 dosis de infliximab, tratamiento biológico que interrumpió 6 meses antes del ingreso actual, por motivos laborales. A la exploración física, el paciente impresionaba de mal estado general, estando febril (39 ºC), hipotenso (TA 80/40 mmHg), taquicárdico (104 lpm) y taquipneico (22 rpm). En fosa iliaca derecha se le palpaba un "efecto masa", de consistencia aumentada y se objetivaba un orificio fistuloso en glúteo izquierdo sobre un área indurada, eritematosa, caliente y dolorosa. La analítica urgente mostraba anemia (Hb 7,9 g/dl, Hcto 29%), insuficiencia renal (creatinina 4 mg/dl) y elevación de reactantes de fase aguda (PCR 127, plaquetas 424.000/ml). Con el probable diagnóstico de sepsis e insuficiencia renal multifactorial (salicilatos, deshidratación,...) se instauró tratamiento con sueroterapia y antibioterapia de amplio espectro. Durante las siguientes 24 horas, el paciente presentó desorientación, agitación y deterioro de su función renal con evidentes alteraciones metabólicas e hidroelectrolíticas (urea 68 mmol/l, creatinina 6,9 mg/dl, sodio 138 mmol/l, potasio 6 mmol/l, calcio total 7,5 mmol/l, fósforo inorgánico 5,1 mmol/l, LDH 17.481 U/l, urato 44 mg/dl). A la vista de estos resultados, se realizó una ecografia Doppler renal que resultó anodina, interpretándose el fracaso renal como de origen multifactorial agravado por la precipitación de cristales de ácido úrico, para lo que se instauró tratamiento con hiperhidratación, alcalinización de la orina, hemodiálisis, alopurinol y rasburicasa con marcado descenso de los niveles de urato (urato 1,8 mg/dl). No obstante, ante el empeoramiento clínico progresivo del estado general del paciente se realizó un TAC abdominopélvico que demostró una masa retroperitoneal, de 13 x 10 cm y una lesión, en flanco derecho, de 15 x 8,6 cm, que parecía corresponder a un conglomerado de asas fijas con pared engrosada, sin poder descartar una neoplasia subyacente. También se apreciaron múltiples adenopatías en cadena mesentérica, iliacas e inguinales, así como una lesión perirrectal izquierda, en probable relación a su antecedente de absceso y fístula perianal. Esta última lesión era el único hallazgo radiológico objetivado, dos meses antes del episodio actual, en una resonancia abdomino-pélvica de control de su enfermedad perianal. A pesar del tratamiento de soporte instaurado, el paciente continuó con fiebre, disminución del nivel de consciencia, disnea progresiva y anuria, falleciendo tres días después de su ingreso en planta. El diagnóstico definitivo fue obtenido tras la realización de una necropsia: plasmocitoma plasmoblástico con predominio de cadenas ligeras tipo lamda que infiltraba íleon terminal y ciego, raíz del mesenterio, ganglios linfáticos abdominales y médula ósea.

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[ "PROTEINAS", "NORMALIZABLES" ]

Behandlung is an umlsterm, Verletzungen is an umlsterm, Wirbelsaeule is an umlsterm, unfallchirurgische is an umlsterm, Deutschland is an umlsterm, Oesterreich is an umlsterm, Wirbelsaeule is an umlsterm, Gesellschaft is an umlsterm, Patienten is an umlsterm, maennlich is an umlsterm, Patienten is an umlsterm, Verletzung is an umlsterm, Wirbelsaeulen- is an umlsterm, Komplikationen is an umlsterm, Behandlung is an umlsterm, Rehabilitation is an umlsterm, Analyse is an umlsterm, Unfallursachen is an umlsterm, Hoehe is an umlsterm, Verkehrsunfaelle is an umlsterm, Lendenwirbelkoerper is an umlsterm, Verletzungen is an umlsterm, Patienten is an umlsterm, Kompressionsverletzungen is an umlsterm, Wirbelsaeulenverletzung is an umlsterm, Extremitaeten is an umlsterm, Thorax is an umlsterm, Patienten is an umlsterm, Verkehrsunfallopfer is an umlsterm, Rotationsverletzung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Laehmung is an umlsterm, Paraplegie is an umlsterm, Patienten is an umlsterm, Unfall is an umlsterm, Patienten is an umlsterm, Wirbelsaeule is an umlsterm, Patienten is an umlsterm, Unfalls is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm, Freizeitaktivitaeten is an umlsterm, Rueckenbeweglichkeit is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Unfall is an umlsterm

DerUnfallchirurg.91020924.ger.abstr_task0

Sentence: Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .

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[ "umlsterm" ]

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DerUnfallchirurg.91020924.ger.abstr_task1

Sentence: Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . Instructions: please typing these entity words according to sentence: Behandlung, Verletzungen, Wirbelsaeule, unfallchirurgische, Deutschland, Oesterreich, Wirbelsaeule, Gesellschaft, Patienten, maennlich, Patienten, Verletzung, Wirbelsaeulen-, Komplikationen, Behandlung, Rehabilitation, Analyse, Unfallursachen, Hoehe, Verkehrsunfaelle, Lendenwirbelkoerper, Verletzungen, Patienten, Kompressionsverletzungen, Wirbelsaeulenverletzung, Extremitaeten, Thorax, Patienten, Verkehrsunfallopfer, Rotationsverletzung, Patienten, Patienten, Laehmung, Paraplegie, Patienten, Unfall, Patienten, Wirbelsaeule, Patienten, Unfalls, Arbeit, Patienten, Freizeitaktivitaeten, Rueckenbeweglichkeit, Patienten, Zeit, Unfall Options: umlsterm

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Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .

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[ "umlsterm" ]

Behandlung, Verletzungen, Wirbelsaeule, unfallchirurgische, Deutschland, Oesterreich, Wirbelsaeule, Gesellschaft, Patienten, maennlich, Patienten, Verletzung, Wirbelsaeulen-, Komplikationen, Behandlung, Rehabilitation, Analyse, Unfallursachen, Hoehe, Verkehrsunfaelle, Lendenwirbelkoerper, Verletzungen, Patienten, Kompressionsverletzungen, Wirbelsaeulenverletzung, Extremitaeten, Thorax, Patienten, Verkehrsunfallopfer, Rotationsverletzung, Patienten, Patienten, Laehmung, Paraplegie, Patienten, Unfall, Patienten, Wirbelsaeule, Patienten, Unfalls, Arbeit, Patienten, Freizeitaktivitaeten, Rueckenbeweglichkeit, Patienten, Zeit, Unfall

DerUnfallchirurg.91020924.ger.abstr_task2

Sentence: Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte . Instructions: please extract entity words from the input sentence

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Die Autoren berichten ueber eine prospektive , multizentrische Studie zur operativen Behandlung frischer Verletzungen des thorakolumbalen Uebergangs der Wirbelsaeule . An der noch nicht abgeschlossenen Studie sind insgesamt 18 unfallchirurgische Kliniken in Deutschland und Oesterreich beteiligt ; sie bilden die Arbeitsgemeinschaft " Wirbelsaeule " der Deutschen Gesellschaft fuer Unfallchirurgie . Von September 1994 bis Dezember 1996 wurden 682 Patienten ( 64 % maennlich ) mit einem Durchschnittsalter von 391/2 ( 7-83 ) Jahren erfasst . Die Eingangkriterien schlossen alle Patienten mit frischer und innerhalb von 3 Wochen operierter thorakolumbaler Verletzung ( Th 10-L 2 ) ein . Im Teil 1 des Berichts schildern wir den Aufbau der Studie und epidemiologische Daten . Haeufigkeit und Art von Wirbelsaeulen- und Begleitverletzungen wurden ebenso einheitlich erfasst wie Angaben zu den verschiedenen operativen Behandlungskonzepten und Komplikationen , der Dauer der Behandlung , Rehabilitation und Arbeitsunfaehigkeit . Die Analyse des klinischen , sozialen und roentgenologischen Verlaufs stellte einen weiteren Schwerpunkt dar . Haeufigste Unfallursachen waren Stuerze aus der Hoehe ( 50 % ) und Verkehrsunfaelle ( 22 % ) . Der erste Lendenwirbelkoerper war mit Abstand am haeufigsten betroffen ( 49 % ) . Alle Verletzungen wurden nach der AO-Einteilung klassifiziert ; 65 % aller Patienten erlitten Kompressionsverletzungen ( Typ A ) . Bei 59 % lag eine isolierte Wirbelsaeulenverletzung vor , die uebrigen wiesen Begleitverletzungen auf und 6 % waren polytraumatisiert . Begleitverletzungen betrafen am haeufigsten Extremitaeten und Thorax . Juengere Patienten und Verkehrsunfallopfer erlitten haeufiger eine Rotationsverletzung ( Typ C ) und waren haeufiger polytraumatisiert . Mehrsegment- oder Mehretagenlaesionen waren haeufiger bei Polytraumatisierten . Eine inkomplette Querschnittlaesion ( Frankel/ASIA B-D ) wiesen 16 % , eine komplette ( Frankel/ASIA A ) 5 % auf . Der Anteil neurologisch beeintraechtigter Patienten nahm mit der Verletzungsschwere signifikant zu . Bei 32 % der Patienten mit inkomplettter Laehmung besserte sich der neurologische Befund bis zur Entlassung um mindestens 1 Stufe nach dem Frankel-/ASIA-Schema, bei 12 % nach Paraplegie . Zu einer Verschlechterung um mindestens 1 Stufe kam es bei 3 Patienten ( 0,4 % ) . Als Grundlage differenzierter Nachuntersuchungsergebnisse wurden Angaben zur individuellen Situation vor dem Unfall erfasst : 277 ( 40,6 % ) Patienten wiesen Vorerkrankungen auf , etwa die Haelfte davon solche der Wirbelsaeule . 559 ( 82,0 % ) Patienten waren zum Zeitpunkt des Unfalls berufstaetig ; 429 ( 62,9 % ) gingen einer koerperlichen Arbeit nach . 369 ( 54,1 % ) Patienten gaben sportliche Freizeitaktivitaeten an und 561 ( 82,3 % ) bezeichneten ihre Rueckenbeweglichkeit als normal . Im Hannover Wirbelsaeulen-Score ( 0-100 Punkte zu Beschwerden und Funktion ) erzielten die Patienten fuer die Zeit vor dem Unfall im Mittel 93,4 Punkte .

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[ "umlsterm" ]

Mesenchymale is an umlsterm, Tumoren is an umlsterm, Neoplasien is an umlsterm, Lipom is an umlsterm, Dermis is an umlsterm, pleomorphe Lipom is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, Dermis is an umlsterm, Prognose is an umlsterm, Tumoren is an umlsterm, Liposarkom is an umlsterm, Klassifizierung is an umlsterm, Neoplasien is an umlsterm, Biologie is an umlsterm, Tumoren is an umlsterm

DerPathologe.00210441.ger.abstr_task0

Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .

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[ "umlsterm" ]

Mesenchymale is an umlsterm, Tumoren is an umlsterm, Neoplasien is an umlsterm, Lipom is an umlsterm, Dermis is an umlsterm, pleomorphe Lipom is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, Dermis is an umlsterm, Prognose is an umlsterm, Tumoren is an umlsterm, Liposarkom is an umlsterm, Klassifizierung is an umlsterm, Neoplasien is an umlsterm, Biologie is an umlsterm, Tumoren is an umlsterm

DerPathologe.00210441.ger.abstr_task1

Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please typing these entity words according to sentence: Mesenchymale, Tumoren, Neoplasien, Lipom, Dermis, pleomorphe Lipom, Neoplasien, Neoplasien, Dermis, Prognose, Tumoren, Liposarkom, Klassifizierung, Neoplasien, Biologie, Tumoren Options: umlsterm

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Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .

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[ "umlsterm" ]

Mesenchymale, Tumoren, Neoplasien, Lipom, Dermis, pleomorphe Lipom, Neoplasien, Neoplasien, Dermis, Prognose, Tumoren, Liposarkom, Klassifizierung, Neoplasien, Biologie, Tumoren

DerPathologe.00210441.ger.abstr_task2

Sentence: Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen . Instructions: please extract entity words from the input sentence

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Mesenchymale Tumoren lipogener Differenzierung stellen die groesste Gruppe der insgesamt seltenen und heterogenen Weichgewebstumoren dar . In den letzten Jahren sind in diesem Spektrum eine Reihe " neuer " Entitaeten und Formvarianten beschrieben und charakterisiert worden , deren Kenntnis bei der richtigen klinisch-prognostischen Einordnung von besonderer Bedeutung ist , um eine eventuelle Verwechslung mit klinisch aggressiveren bzw. harmloseren Neoplasien und damit eine Unter- bzw. Uebertherapie zu vermeiden . Zu diesen Entitaeten gehoeren das chondroide Lipom und das Myolipom sowie das auf die Dermis begrenzte Spindelzell- und pleomorphe Lipom , die biologisch benigne Neoplasien darstellen , morphologisch aber sarkomatoese Neoplasien imitieren koennen . Auf die Dermis beschraenkte Liposarkome sind trotz einer teilweise hochmalignen Morphologie durch eine gute klinische Prognose charakterisiert . Im Spektrum der atypischen lipomatoesen Tumoren ( gut differenzierte Liposarkome ) wurde mit dem gut differenzierten spindelzelligen Liposarkom eine seltene Formvariante beschrieben , die von metastasierungsfaehigen dedifferenzierten Liposarkomen einerseits und von benignen Spindelzelllipomen andererseits abzugrenzen ist . Darueber hinaus haben umfangreiche zytogenetische und molekularpathologische Untersuchungen von Fettgewebstumoren zu Modifizierungen bei der Klassifizierung lipogener Neoplasien gefuehrt und zu einem besseren Verstaendnis der Biologie dieser Gruppe der mesenchymalen Tumoren beigetragen .

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[ "umlsterm" ]

dyslipidemia is a Condition, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl is a Scope, Lipid - lowering treatment is a Procedure, stable is a Qualifier, in the last month is a Temporal, LDL - cholesterol is a Measurement, above 100 mg / dl is a Value, in the month prior to inclusion is a Temporal, apnea - hypopnea index is a Measurement, between 5 - 30 h-1 is a Value

NCT02557412_inc_task0

Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Procedure, Scope, Measurement

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Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1

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[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]

dyslipidemia is a Condition, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl is a Scope, Lipid - lowering treatment is a Procedure, stable is a Qualifier, in the last month is a Temporal, LDL - cholesterol is a Measurement, above 100 mg / dl is a Value, in the month prior to inclusion is a Temporal, apnea - hypopnea index is a Measurement, between 5 - 30 h-1 is a Value

NCT02557412_inc_task1

Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please typing these entity words according to sentence: dyslipidemia, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl, Lipid - lowering treatment, stable, in the last month, LDL - cholesterol, above 100 mg / dl, in the month prior to inclusion, apnea - hypopnea index, between 5 - 30 h-1 Options: Temporal, Condition, Qualifier, Value, Procedure, Scope, Measurement

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Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1

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[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]

dyslipidemia, dyslipidemia associated with lipid - lowering therapy . It is also considered patients who have an altered analytical , using the following cutoffs : total cholesterol = 200 mg / dl , triglycerides = 180 mg / dl , HDL - cholesterol = 40 mg / dl or LDL - cholesterol = 150 mg / dl, Lipid - lowering treatment, stable, in the last month, LDL - cholesterol, above 100 mg / dl, in the month prior to inclusion, apnea - hypopnea index, between 5 - 30 h-1

NCT02557412_inc_task2

Sentence: Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1 Instructions: please extract entity words from the input sentence

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Diagnosis of dyslipidemia: The existence of a previous clinical diagnostic of dyslipidemia associated with lipid-lowering therapy. It is also considered patients who have an altered analytical, using the following cutoffs: total cholesterol = 200 mg / dl, triglycerides = 180 mg / dl, HDL-cholesterol = 40 mg / dl or LDL-cholesterol = 150 mg / dl. Lipid-lowering treatment and diet, stable in the last month. A concentration of LDL-cholesterol above 100 mg / dl, in the month prior to inclusion. An apnea-hypopnea index between 5-30 h-1

[ "Diagnosis", "of", "dyslipidemia", ":", "The", "existence", "of", "a", "previous", "clinical", "diagnostic", "of", "dyslipidemia", "associated", "with", "lipid", "-", "lowering", "therapy", ".", "It", "is", "also", "considered", "patients", "who", "have", "an", "altered", "analytical", ",", "using", "the", "following", "cutoffs", ":", "total", "cholesterol", "=", "200", "mg", "/", "dl", ",", "triglycerides", "=", "180", "mg", "/", "dl", ",", "HDL", "-", "cholesterol", "=", "40", "mg", "/", "dl", "or", "LDL", "-", "cholesterol", "=", "150", "mg", "/", "dl", ".", "Lipid", "-", "lowering", "treatment", "and", "diet", ",", "stable", "in", "the", "last", "month", ".", "\n", "A", "concentration", "of", "LDL", "-", "cholesterol", "above", "100", "mg", "/", "dl", ",", "in", "the", "month", "prior", "to", "inclusion", ".", "\n", "An", "apnea", "-", "hypopnea", "index", "between", "5", "-", "30", "h-1", "\n" ]

[ "Scope", "Temporal", "Procedure", "Measurement", "Condition", "Value", "Reference_point", "Qualifier" ]