bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
Rac is a protein-family, GTP is a chemical, Rac is a protein-family	1.0alpha7.train.905_task0	Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: chemical, protein-family	[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]	Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.	[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]	[ "chemical", "protein-family" ]
Rac is a protein-family, GTP is a chemical, Rac is a protein-family	1.0alpha7.train.905_task1	Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please typing these entity words according to sentence: Rac, GTP, Rac Options: chemical, protein-family	[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]	Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.	[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]	[ "chemical", "protein-family" ]
Rac, GTP, Rac	1.0alpha7.train.905_task2	Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please extract entity words from the input sentence	[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]	Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.	[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]	[ "chemical", "protein-family" ]
Rueckenmarks is an umlsterm, Anaesthesie is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Komplikationen is an umlsterm	DerAnaesthesist.50440483.ger.abstr_task0	Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .	[ "Der", "Morbus", "Friedreich", "stellt", "eine", "sehr", "seltene", "neurologische", "Erkrankung", "dar", ",", "bei", "der", "es", "bereits", "beim", "jungen", "Erwachsenen", "zu", "Degenerationen", "im", "Bereich", "der", "Hinterwurzel", "und", "schliesslich", "im", "Bereich", "der", "Vorderwurzel", "des", "Rueckenmarks", "kommt", ".", "Besonders", "im", "Rahmen", "des", "Bereitschaftsdienstes", "steht", "man", "ploetzlich", "vor", "der", "Frage", ",", "ob", "im", "Rahmen", "einer", "Anaesthesie", "eines", "solchen", "Patienten", "eher", "der", "Intubationsnarkose", ",", "oder", "aber", "einem", "regionalen", "Betaeubungsverfahren", "der", "Vorzug", "gegeben", "werden", "sollte", ".", "Wir", "berichten", "ueber", "eine", "36jaehrige", "Patientin", "mit", "einer", "spinocerebellaeren", "heredoataxie", "(", "Morbus", "Friedreich", ")", ",", "die", "sich", "einem", "proktologischen", "Eingriff", "unterziehen", "musste", ".", "Hierbei", "erfolgte", "eine", "Spinalanaesthesie", "mittels", "3", "mg", "hyperbarem", "Bupivacain", "im", "Sitzen", ".", "Sowohl", "der", "intra-", "als", "auch", "der", "postoperative", "Verlauf", "waren", "unauffaellig", ",", "insbesondere", "in", "bezug", "auf", "die", "neurologische", "Grunderkrankung", "kam", "es", "zu", "keinerlei", "Komplikationen", "." ]	[ "umlsterm" ]
Rueckenmarks is an umlsterm, Anaesthesie is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Komplikationen is an umlsterm	DerAnaesthesist.50440483.ger.abstr_task1	Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please typing these entity words according to sentence: Rueckenmarks, Anaesthesie, Patienten, Bupivacain, Komplikationen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .	[ "Der", "Morbus", "Friedreich", "stellt", "eine", "sehr", "seltene", "neurologische", "Erkrankung", "dar", ",", "bei", "der", "es", "bereits", "beim", "jungen", "Erwachsenen", "zu", "Degenerationen", "im", "Bereich", "der", "Hinterwurzel", "und", "schliesslich", "im", "Bereich", "der", "Vorderwurzel", "des", "Rueckenmarks", "kommt", ".", "Besonders", "im", "Rahmen", "des", "Bereitschaftsdienstes", "steht", "man", "ploetzlich", "vor", "der", "Frage", ",", "ob", "im", "Rahmen", "einer", "Anaesthesie", "eines", "solchen", "Patienten", "eher", "der", "Intubationsnarkose", ",", "oder", "aber", "einem", "regionalen", "Betaeubungsverfahren", "der", "Vorzug", "gegeben", "werden", "sollte", ".", "Wir", "berichten", "ueber", "eine", "36jaehrige", "Patientin", "mit", "einer", "spinocerebellaeren", "heredoataxie", "(", "Morbus", "Friedreich", ")", ",", "die", "sich", "einem", "proktologischen", "Eingriff", "unterziehen", "musste", ".", "Hierbei", "erfolgte", "eine", "Spinalanaesthesie", "mittels", "3", "mg", "hyperbarem", "Bupivacain", "im", "Sitzen", ".", "Sowohl", "der", "intra-", "als", "auch", "der", "postoperative", "Verlauf", "waren", "unauffaellig", ",", "insbesondere", "in", "bezug", "auf", "die", "neurologische", "Grunderkrankung", "kam", "es", "zu", "keinerlei", "Komplikationen", "." ]	[ "umlsterm" ]
Rueckenmarks, Anaesthesie, Patienten, Bupivacain, Komplikationen	DerAnaesthesist.50440483.ger.abstr_task2	Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .	[ "Der", "Morbus", "Friedreich", "stellt", "eine", "sehr", "seltene", "neurologische", "Erkrankung", "dar", ",", "bei", "der", "es", "bereits", "beim", "jungen", "Erwachsenen", "zu", "Degenerationen", "im", "Bereich", "der", "Hinterwurzel", "und", "schliesslich", "im", "Bereich", "der", "Vorderwurzel", "des", "Rueckenmarks", "kommt", ".", "Besonders", "im", "Rahmen", "des", "Bereitschaftsdienstes", "steht", "man", "ploetzlich", "vor", "der", "Frage", ",", "ob", "im", "Rahmen", "einer", "Anaesthesie", "eines", "solchen", "Patienten", "eher", "der", "Intubationsnarkose", ",", "oder", "aber", "einem", "regionalen", "Betaeubungsverfahren", "der", "Vorzug", "gegeben", "werden", "sollte", ".", "Wir", "berichten", "ueber", "eine", "36jaehrige", "Patientin", "mit", "einer", "spinocerebellaeren", "heredoataxie", "(", "Morbus", "Friedreich", ")", ",", "die", "sich", "einem", "proktologischen", "Eingriff", "unterziehen", "musste", ".", "Hierbei", "erfolgte", "eine", "Spinalanaesthesie", "mittels", "3", "mg", "hyperbarem", "Bupivacain", "im", "Sitzen", ".", "Sowohl", "der", "intra-", "als", "auch", "der", "postoperative", "Verlauf", "waren", "unauffaellig", ",", "insbesondere", "in", "bezug", "auf", "die", "neurologische", "Grunderkrankung", "kam", "es", "zu", "keinerlei", "Komplikationen", "." ]	[ "umlsterm" ]
Gro - interaction domain is a protein-domain, Lz is a protein, VWRPY is a protein-motif, VWEAA is a protein-motif, Gro is a protein, bHLH proteins is a protein-family	1.0alpha7.train.742_task0	Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-motif, protein-domain, protein, protein-family	[ "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-motif", "O", "B-protein-motif", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).	[ "We", "therefore", "altered", "the", " ", "Gro", "-", "interaction", "domain", "at", "the", "C", "terminus", "of", " ", "Lz", "from", "VWRPY", "to", "VWEAA", ",", "a", "change", "that", "abrogates", " ", "Gro", "binding", "to", " ", "bHLH", "proteins", "(", "Goldstein", "et", "al", ".", "1999", " ", ")", "." ]	[ "protein-domain", "protein-family", "protein-motif", "protein" ]
Gro - interaction domain is a protein-domain, Lz is a protein, VWRPY is a protein-motif, VWEAA is a protein-motif, Gro is a protein, bHLH proteins is a protein-family	1.0alpha7.train.742_task1	Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please typing these entity words according to sentence: Gro - interaction domain, Lz, VWRPY, VWEAA, Gro, bHLH proteins Options: protein-motif, protein-domain, protein, protein-family	[ "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-motif", "O", "B-protein-motif", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).	[ "We", "therefore", "altered", "the", " ", "Gro", "-", "interaction", "domain", "at", "the", "C", "terminus", "of", " ", "Lz", "from", "VWRPY", "to", "VWEAA", ",", "a", "change", "that", "abrogates", " ", "Gro", "binding", "to", " ", "bHLH", "proteins", "(", "Goldstein", "et", "al", ".", "1999", " ", ")", "." ]	[ "protein-domain", "protein-family", "protein-motif", "protein" ]
Gro - interaction domain, Lz, VWRPY, VWEAA, Gro, bHLH proteins	1.0alpha7.train.742_task2	Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-protein-domain", "I-protein-domain", "I-protein-domain", "I-protein-domain", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-motif", "O", "B-protein-motif", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).	[ "We", "therefore", "altered", "the", " ", "Gro", "-", "interaction", "domain", "at", "the", "C", "terminus", "of", " ", "Lz", "from", "VWRPY", "to", "VWEAA", ",", "a", "change", "that", "abrogates", " ", "Gro", "binding", "to", " ", "bHLH", "proteins", "(", "Goldstein", "et", "al", ".", "1999", " ", ")", "." ]	[ "protein-domain", "protein-family", "protein-motif", "protein" ]
knowledge is an umlsterm, nerve regeneration is an umlsterm, repair is an umlsterm, nerve is an umlsterm, traumatic injury is an umlsterm, central nervous system is an umlsterm, CNS is an umlsterm, regeneration is an umlsterm, functional recovery is an umlsterm, spinal cord injury is an umlsterm, animal models is an umlsterm, growth - inhibitory is an umlsterm, CNS is an umlsterm, neurons is an umlsterm, therapies is an umlsterm, treatment is an umlsterm, spinal cord is an umlsterm, patients is an umlsterm, neurobiology is an umlsterm, spinal cord trauma is an umlsterm, findings is an umlsterm, light is an umlsterm	DerNervenarzt.90700702.eng.abstr_task0	Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .	[ "In", "recent", "years", ",", "a", "more", "precise", "neurobiological", "knowledge", "has", "been", "gained", "concerning", "the", "various", "cellular", "parameters", "which", "mediate", "successful", "peripheral", "nerve", "regeneration", ",", "and", "also", "those", "which", "prevent", "repair", "of", "damaged", "nerve", "fibre", "pathways", "following", "traumatic", "injury", "to", "the", "the", "central", "nervous", "system", "(", "CNS", ")", ".", "On", "this", "basis", ",", "a", "range", "of", "experimental", "therapeutical", "approaches", "for", "promoting", "axonal", "regeneration", "and", "functional", "recovery", "after", "spinal", "cord", "injury", "have", "been", "developed", "in", "animal", "models", ".", "Such", "intervention", "strategies", "focus", "on", "the", "molecular", "inactivation", "of", "glial", "-", "associated", "growth", "-", "inhibitory", "factors", "and", "on", "the", "application", "of", "trophic", "molecules", "and", "cellular", "substrates", "which", "enhance", "the", "postlesional", "regenerative", "potential", "of", "intrinsic", "CNS", "neurons", ".", "At", "the", "present", ",", "these", "experimental", "therapies", "cannot", "be", "transferred", "to", "the", "clinical", "situation", "for", "the", "treatment", "of", "spinal", "cord", "injured", "patients", ".", "This", "overview", "briefly", "summarizes", "current", "progress", "in", "the", "neurobiology", "of", "spinal", "cord", "trauma", ",", "the", "main", "findings", "of", "which", "are", "discussed", "in", "the", "light", "of", "clinical", "expectations", "." ]	[ "umlsterm" ]
knowledge is an umlsterm, nerve regeneration is an umlsterm, repair is an umlsterm, nerve is an umlsterm, traumatic injury is an umlsterm, central nervous system is an umlsterm, CNS is an umlsterm, regeneration is an umlsterm, functional recovery is an umlsterm, spinal cord injury is an umlsterm, animal models is an umlsterm, growth - inhibitory is an umlsterm, CNS is an umlsterm, neurons is an umlsterm, therapies is an umlsterm, treatment is an umlsterm, spinal cord is an umlsterm, patients is an umlsterm, neurobiology is an umlsterm, spinal cord trauma is an umlsterm, findings is an umlsterm, light is an umlsterm	DerNervenarzt.90700702.eng.abstr_task1	Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please typing these entity words according to sentence: knowledge, nerve regeneration, repair, nerve, traumatic injury, central nervous system, CNS, regeneration, functional recovery, spinal cord injury, animal models, growth - inhibitory, CNS, neurons, therapies, treatment, spinal cord, patients, neurobiology, spinal cord trauma, findings, light Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .	[ "In", "recent", "years", ",", "a", "more", "precise", "neurobiological", "knowledge", "has", "been", "gained", "concerning", "the", "various", "cellular", "parameters", "which", "mediate", "successful", "peripheral", "nerve", "regeneration", ",", "and", "also", "those", "which", "prevent", "repair", "of", "damaged", "nerve", "fibre", "pathways", "following", "traumatic", "injury", "to", "the", "the", "central", "nervous", "system", "(", "CNS", ")", ".", "On", "this", "basis", ",", "a", "range", "of", "experimental", "therapeutical", "approaches", "for", "promoting", "axonal", "regeneration", "and", "functional", "recovery", "after", "spinal", "cord", "injury", "have", "been", "developed", "in", "animal", "models", ".", "Such", "intervention", "strategies", "focus", "on", "the", "molecular", "inactivation", "of", "glial", "-", "associated", "growth", "-", "inhibitory", "factors", "and", "on", "the", "application", "of", "trophic", "molecules", "and", "cellular", "substrates", "which", "enhance", "the", "postlesional", "regenerative", "potential", "of", "intrinsic", "CNS", "neurons", ".", "At", "the", "present", ",", "these", "experimental", "therapies", "cannot", "be", "transferred", "to", "the", "clinical", "situation", "for", "the", "treatment", "of", "spinal", "cord", "injured", "patients", ".", "This", "overview", "briefly", "summarizes", "current", "progress", "in", "the", "neurobiology", "of", "spinal", "cord", "trauma", ",", "the", "main", "findings", "of", "which", "are", "discussed", "in", "the", "light", "of", "clinical", "expectations", "." ]	[ "umlsterm" ]
knowledge, nerve regeneration, repair, nerve, traumatic injury, central nervous system, CNS, regeneration, functional recovery, spinal cord injury, animal models, growth - inhibitory, CNS, neurons, therapies, treatment, spinal cord, patients, neurobiology, spinal cord trauma, findings, light	DerNervenarzt.90700702.eng.abstr_task2	Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .	[ "In", "recent", "years", ",", "a", "more", "precise", "neurobiological", "knowledge", "has", "been", "gained", "concerning", "the", "various", "cellular", "parameters", "which", "mediate", "successful", "peripheral", "nerve", "regeneration", ",", "and", "also", "those", "which", "prevent", "repair", "of", "damaged", "nerve", "fibre", "pathways", "following", "traumatic", "injury", "to", "the", "the", "central", "nervous", "system", "(", "CNS", ")", ".", "On", "this", "basis", ",", "a", "range", "of", "experimental", "therapeutical", "approaches", "for", "promoting", "axonal", "regeneration", "and", "functional", "recovery", "after", "spinal", "cord", "injury", "have", "been", "developed", "in", "animal", "models", ".", "Such", "intervention", "strategies", "focus", "on", "the", "molecular", "inactivation", "of", "glial", "-", "associated", "growth", "-", "inhibitory", "factors", "and", "on", "the", "application", "of", "trophic", "molecules", "and", "cellular", "substrates", "which", "enhance", "the", "postlesional", "regenerative", "potential", "of", "intrinsic", "CNS", "neurons", ".", "At", "the", "present", ",", "these", "experimental", "therapies", "cannot", "be", "transferred", "to", "the", "clinical", "situation", "for", "the", "treatment", "of", "spinal", "cord", "injured", "patients", ".", "This", "overview", "briefly", "summarizes", "current", "progress", "in", "the", "neurobiology", "of", "spinal", "cord", "trauma", ",", "the", "main", "findings", "of", "which", "are", "discussed", "in", "the", "light", "of", "clinical", "expectations", "." ]	[ "umlsterm" ]
NF - kappaB is a Complex, RelA is a Gene_or_gene_product, protein kinase Czeta is a Gene_or_gene_product, NF - kappaB is a Complex, cytoplasmic is a Cellular_component, IkappaB is a Gene_or_gene_product, NF - kappaB is a Complex, RelA is a Gene_or_gene_product, NF - kappaB is a Complex, protein kinase Czeta is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Rel is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Raf is a Gene_or_gene_product, MEK is a Gene_or_gene_product, phosphatidylinositol 3-kinase is a Gene_or_gene_product, stress - activated protein kinase is a Gene_or_gene_product	1_task0	Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Complex, Gene_or_gene_product, Cellular_component	[ "O", "O", "B-Complex", "I-Complex", "I-Complex", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.	[ "Regulation", "of", "NF", "-", "kappaB", "RelA", "phosphorylation", "and", "transcriptional", "activity", "by", "p21(ras", ")", "and", "protein", "kinase", "Czeta", "in", "primary", "endothelial", "cells", ".", "\n", "The", "activity", "of", "the", "transcription", "factor", "NF", "-", "kappaB", "is", "thought", "to", "be", "regulated", "mainly", "through", "cytoplasmic", "retention", "by", "IkappaB", "molecules", ".", "Here", "we", "present", "evidence", "of", "a", "second", "mechanism", "of", "regulation", "acting", "on", "NF", "-", "kappaB", "after", "release", "from", "IkappaB.", "In", "endothelial", "cells", "this", "mechanism", "involves", "phosphorylation", "of", "the", "RelA", "subunit", "of", "NF", "-", "kappaB", "through", "a", "pathway", "involving", "activation", "of", "protein", "kinase", "Czeta", "(", "PKCzeta", ")", "and", "p21(ras", ")", ".", "We", "show", "that", "transcriptional", "activity", "of", "RelA", "is", "dependent", "on", "phosphorylation", "of", "the", "N", "-", "terminal", "Rel", "homology", "domain", "but", "not", "the", "C", "-", "terminal", "transactivation", "domain", ".", "Inhibition", "of", "phosphorylation", "by", "dominant", "negative", "mutants", "of", "PKCzeta", "or", "p21(ras", ")", "results", "in", "loss", "of", "RelA", "transcriptional", "activity", "without", "interfering", "with", "DNA", "binding", ".", "Raf", "/", "MEK", ",", "small", "GTPases", ",", "phosphatidylinositol", "3-kinase", ",", "and", "stress", "-", "activated", "protein", "kinase", "pathways", "are", "not", "involved", "in", "this", "mechanism", "of", "regulation", ".", "\n" ]	[ "Gene_or_gene_product", "Cellular_component", "Complex" ]
NF - kappaB is a Complex, RelA is a Gene_or_gene_product, protein kinase Czeta is a Gene_or_gene_product, NF - kappaB is a Complex, cytoplasmic is a Cellular_component, IkappaB is a Gene_or_gene_product, NF - kappaB is a Complex, RelA is a Gene_or_gene_product, NF - kappaB is a Complex, protein kinase Czeta is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Rel is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Raf is a Gene_or_gene_product, MEK is a Gene_or_gene_product, phosphatidylinositol 3-kinase is a Gene_or_gene_product, stress - activated protein kinase is a Gene_or_gene_product	1_task1	Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please typing these entity words according to sentence: NF - kappaB, RelA, protein kinase Czeta, NF - kappaB, cytoplasmic, IkappaB, NF - kappaB, RelA, NF - kappaB, protein kinase Czeta, PKCzeta, RelA, Rel, PKCzeta, RelA, Raf, MEK, phosphatidylinositol 3-kinase, stress - activated protein kinase Options: Complex, Gene_or_gene_product, Cellular_component	[ "O", "O", "B-Complex", "I-Complex", "I-Complex", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.	[ "Regulation", "of", "NF", "-", "kappaB", "RelA", "phosphorylation", "and", "transcriptional", "activity", "by", "p21(ras", ")", "and", "protein", "kinase", "Czeta", "in", "primary", "endothelial", "cells", ".", "\n", "The", "activity", "of", "the", "transcription", "factor", "NF", "-", "kappaB", "is", "thought", "to", "be", "regulated", "mainly", "through", "cytoplasmic", "retention", "by", "IkappaB", "molecules", ".", "Here", "we", "present", "evidence", "of", "a", "second", "mechanism", "of", "regulation", "acting", "on", "NF", "-", "kappaB", "after", "release", "from", "IkappaB.", "In", "endothelial", "cells", "this", "mechanism", "involves", "phosphorylation", "of", "the", "RelA", "subunit", "of", "NF", "-", "kappaB", "through", "a", "pathway", "involving", "activation", "of", "protein", "kinase", "Czeta", "(", "PKCzeta", ")", "and", "p21(ras", ")", ".", "We", "show", "that", "transcriptional", "activity", "of", "RelA", "is", "dependent", "on", "phosphorylation", "of", "the", "N", "-", "terminal", "Rel", "homology", "domain", "but", "not", "the", "C", "-", "terminal", "transactivation", "domain", ".", "Inhibition", "of", "phosphorylation", "by", "dominant", "negative", "mutants", "of", "PKCzeta", "or", "p21(ras", ")", "results", "in", "loss", "of", "RelA", "transcriptional", "activity", "without", "interfering", "with", "DNA", "binding", ".", "Raf", "/", "MEK", ",", "small", "GTPases", ",", "phosphatidylinositol", "3-kinase", ",", "and", "stress", "-", "activated", "protein", "kinase", "pathways", "are", "not", "involved", "in", "this", "mechanism", "of", "regulation", ".", "\n" ]	[ "Gene_or_gene_product", "Cellular_component", "Complex" ]
NF - kappaB, RelA, protein kinase Czeta, NF - kappaB, cytoplasmic, IkappaB, NF - kappaB, RelA, NF - kappaB, protein kinase Czeta, PKCzeta, RelA, Rel, PKCzeta, RelA, Raf, MEK, phosphatidylinositol 3-kinase, stress - activated protein kinase	1_task2	Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Complex", "I-Complex", "I-Complex", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "I-Complex", "I-Complex", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.	[ "Regulation", "of", "NF", "-", "kappaB", "RelA", "phosphorylation", "and", "transcriptional", "activity", "by", "p21(ras", ")", "and", "protein", "kinase", "Czeta", "in", "primary", "endothelial", "cells", ".", "\n", "The", "activity", "of", "the", "transcription", "factor", "NF", "-", "kappaB", "is", "thought", "to", "be", "regulated", "mainly", "through", "cytoplasmic", "retention", "by", "IkappaB", "molecules", ".", "Here", "we", "present", "evidence", "of", "a", "second", "mechanism", "of", "regulation", "acting", "on", "NF", "-", "kappaB", "after", "release", "from", "IkappaB.", "In", "endothelial", "cells", "this", "mechanism", "involves", "phosphorylation", "of", "the", "RelA", "subunit", "of", "NF", "-", "kappaB", "through", "a", "pathway", "involving", "activation", "of", "protein", "kinase", "Czeta", "(", "PKCzeta", ")", "and", "p21(ras", ")", ".", "We", "show", "that", "transcriptional", "activity", "of", "RelA", "is", "dependent", "on", "phosphorylation", "of", "the", "N", "-", "terminal", "Rel", "homology", "domain", "but", "not", "the", "C", "-", "terminal", "transactivation", "domain", ".", "Inhibition", "of", "phosphorylation", "by", "dominant", "negative", "mutants", "of", "PKCzeta", "or", "p21(ras", ")", "results", "in", "loss", "of", "RelA", "transcriptional", "activity", "without", "interfering", "with", "DNA", "binding", ".", "Raf", "/", "MEK", ",", "small", "GTPases", ",", "phosphatidylinositol", "3-kinase", ",", "and", "stress", "-", "activated", "protein", "kinase", "pathways", "are", "not", "involved", "in", "this", "mechanism", "of", "regulation", ".", "\n" ]	[ "Gene_or_gene_product", "Cellular_component", "Complex" ]
Mechanical ventilation is an umlsterm, intensive care is an umlsterm, medicine is an umlsterm, ICU is an umlsterm, trauma is an umlsterm, patients is an umlsterm, analgesia is an umlsterm, benzodiazepines is an umlsterm, opioids is an umlsterm, time is an umlsterm, period is an umlsterm, withdrawal syndrome is an umlsterm, tachycardia is an umlsterm, hypertonia is an umlsterm, restlessness is an umlsterm, treatment is an umlsterm, clonidine is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, mechanical ventilation is an umlsterm, sufentanil is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, depression is an umlsterm, fentanyl is an umlsterm, frequency is an umlsterm, patient is an umlsterm, physician is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, period is an umlsterm, ventilation is an umlsterm, discharge is an umlsterm, ICU is an umlsterm	DerChirurg.90700066.eng.abstr_task0	Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .	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Mechanical ventilation is an umlsterm, intensive care is an umlsterm, medicine is an umlsterm, ICU is an umlsterm, trauma is an umlsterm, patients is an umlsterm, analgesia is an umlsterm, benzodiazepines is an umlsterm, opioids is an umlsterm, time is an umlsterm, period is an umlsterm, withdrawal syndrome is an umlsterm, tachycardia is an umlsterm, hypertonia is an umlsterm, restlessness is an umlsterm, treatment is an umlsterm, clonidine is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, mechanical ventilation is an umlsterm, sufentanil is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, depression is an umlsterm, fentanyl is an umlsterm, frequency is an umlsterm, patient is an umlsterm, physician is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, period is an umlsterm, ventilation is an umlsterm, discharge is an umlsterm, ICU is an umlsterm	DerChirurg.90700066.eng.abstr_task1	Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please typing these entity words according to sentence: Mechanical ventilation, intensive care, medicine, ICU, trauma, patients, analgesia, benzodiazepines, opioids, time, period, withdrawal syndrome, tachycardia, hypertonia, restlessness, treatment, clonidine, symptoms, patients, mechanical ventilation, sufentanil, opioid, analgesia, depression, fentanyl, frequency, patient, physician, patients, clonidine, patients, period, ventilation, discharge, ICU Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .	[ "Mechanical", "ventilation", "is", "a", "well", "-", "etablished", "strategy", "in", "intensive", "care", "medicine", ".", "ICU", "trauma", "patients", "require", "analgesia", ",", "and", "sedation", "mostly", "consists", "of", "benzodiazepines", "and", "opioids", "with", "increasing", "doses", "over", "time", ".", "The", "weaning", "period", "is", "complicated", "by", "the", "withdrawal", "syndrome", ",", "showing", "tachycardia", ",", "hypertonia", ",", "tachypnea", "and", "restlessness", ".", "Although", "treatment", "with", "clonidine", "can", "influence", "these", "symptoms", ",", "tachypnea", "still", "remains", "the", "main", "problem", "in", "weaning", "patients", "from", "mechanical", "ventilation", ".", "Adding", "sufentanil", ",", "an", "opioid", "with", "greater", "effects", "on", "analgesia", "than", "on", "respiratory", "depression", "compared", "with", "fentanyl", ",", "tachypnea", "can", "be", "reduced", "to", "normal", "frequency", ".", "In", "this", "way", "weaning", "management", "can", "be", "managed", "more", "easily", "for", "the", "benefit", "of", "both", ",", "the", "patient", "and", "physician", ".", "In", "comparison", "with", "a", "group", "of", "50", "patients", "treated", "with", "clonidine", "alone", ",", "72", "patients", "treated", "with", "clonidine", "/", "sufentanil", "showed", "a", "shorter", "period", "from", "the", "start", "of", "spontaneous", "ventilation", "until", "extubation", "(", "4.8", "vs", "7.6", "days", ")", "and", "until", "discharge", "from", "the", "ICU", "(", "7.7", "vs", "12.4", "days", ")", ".", "The", "number", "of", "reintubations", "caused", "by", "respiratory", "exhaustion", "decreased", "from", "16.0", "to", "2.8", "%", "." ]	[ "umlsterm" ]
Mechanical ventilation, intensive care, medicine, ICU, trauma, patients, analgesia, benzodiazepines, opioids, time, period, withdrawal syndrome, tachycardia, hypertonia, restlessness, treatment, clonidine, symptoms, patients, mechanical ventilation, sufentanil, opioid, analgesia, depression, fentanyl, frequency, patient, physician, patients, clonidine, patients, period, ventilation, discharge, ICU	DerChirurg.90700066.eng.abstr_task2	Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .	[ "Mechanical", "ventilation", "is", "a", "well", "-", "etablished", "strategy", "in", "intensive", "care", "medicine", ".", "ICU", "trauma", "patients", "require", "analgesia", ",", "and", "sedation", "mostly", "consists", "of", "benzodiazepines", "and", "opioids", "with", "increasing", "doses", "over", "time", ".", "The", "weaning", "period", "is", "complicated", "by", "the", "withdrawal", "syndrome", ",", "showing", "tachycardia", ",", "hypertonia", ",", "tachypnea", "and", "restlessness", ".", "Although", "treatment", "with", "clonidine", "can", "influence", "these", "symptoms", ",", "tachypnea", "still", "remains", "the", "main", "problem", "in", "weaning", "patients", "from", "mechanical", "ventilation", ".", "Adding", "sufentanil", ",", "an", "opioid", "with", "greater", "effects", "on", "analgesia", "than", "on", "respiratory", "depression", "compared", "with", "fentanyl", ",", "tachypnea", "can", "be", "reduced", "to", "normal", "frequency", ".", "In", "this", "way", "weaning", "management", "can", "be", "managed", "more", "easily", "for", "the", "benefit", "of", "both", ",", "the", "patient", "and", "physician", ".", "In", "comparison", "with", "a", "group", "of", "50", "patients", "treated", "with", "clonidine", "alone", ",", "72", "patients", "treated", "with", "clonidine", "/", "sufentanil", "showed", "a", "shorter", "period", "from", "the", "start", "of", "spontaneous", "ventilation", "until", "extubation", "(", "4.8", "vs", "7.6", "days", ")", "and", "until", "discharge", "from", "the", "ICU", "(", "7.7", "vs", "12.4", "days", ")", ".", "The", "number", "of", "reintubations", "caused", "by", "respiratory", "exhaustion", "decreased", "from", "16.0", "to", "2.8", "%", "." ]	[ "umlsterm" ]
Kryochirurgie is an umlsterm, Methode is an umlsterm, Behandlung is an umlsterm, Saeuglingshaemangiome is an umlsterm, Zeit is an umlsterm, unterliegenden is an umlsterm, Tumoren is an umlsterm	DerHautarzt.00510231.ger.abstr_task0	Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .	[ "Hintergrund", "und", "Fragestellung", ".", "Kryochirurgie", "ist", "als", "Methode", "zur", "Behandlung", "kapillaerer", "Saeuglingshaemangiome", "seit", "langer", "Zeit", "etabliert", ".", "Erstaunlicherweise", "fehlen", "aber", "bisher", "detaillierte", "Studien", ",", "die", "ihre", "Effektivitaet", "bei", "den", "regelmaessig", "der", "Spontanregression", "unterliegenden", "Tumoren", "belegen", "." ]	[ "umlsterm" ]
Kryochirurgie is an umlsterm, Methode is an umlsterm, Behandlung is an umlsterm, Saeuglingshaemangiome is an umlsterm, Zeit is an umlsterm, unterliegenden is an umlsterm, Tumoren is an umlsterm	DerHautarzt.00510231.ger.abstr_task1	Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please typing these entity words according to sentence: Kryochirurgie, Methode, Behandlung, Saeuglingshaemangiome, Zeit, unterliegenden, Tumoren Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .	[ "Hintergrund", "und", "Fragestellung", ".", "Kryochirurgie", "ist", "als", "Methode", "zur", "Behandlung", "kapillaerer", "Saeuglingshaemangiome", "seit", "langer", "Zeit", "etabliert", ".", "Erstaunlicherweise", "fehlen", "aber", "bisher", "detaillierte", "Studien", ",", "die", "ihre", "Effektivitaet", "bei", "den", "regelmaessig", "der", "Spontanregression", "unterliegenden", "Tumoren", "belegen", "." ]	[ "umlsterm" ]
Kryochirurgie, Methode, Behandlung, Saeuglingshaemangiome, Zeit, unterliegenden, Tumoren	DerHautarzt.00510231.ger.abstr_task2	Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .	[ "Hintergrund", "und", "Fragestellung", ".", "Kryochirurgie", "ist", "als", "Methode", "zur", "Behandlung", "kapillaerer", "Saeuglingshaemangiome", "seit", "langer", "Zeit", "etabliert", ".", "Erstaunlicherweise", "fehlen", "aber", "bisher", "detaillierte", "Studien", ",", "die", "ihre", "Effektivitaet", "bei", "den", "regelmaessig", "der", "Spontanregression", "unterliegenden", "Tumoren", "belegen", "." ]	[ "umlsterm" ]
( Na+ + K+)-ATPase beta - subunit is a Protein, Asn-157 is a Entity, Asn-192 is a Entity, Asn-264 is a Entity	318_task0	Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.	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( Na+ + K+)-ATPase beta - subunit is a Protein, Asn-157 is a Entity, Asn-192 is a Entity, Asn-264 is a Entity	318_task1	Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please typing these entity words according to sentence: ( Na+ + K+)-ATPase beta - subunit, Asn-157, Asn-192, Asn-264 Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.	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( Na+ + K+)-ATPase beta - subunit, Asn-157, Asn-192, Asn-264	318_task2	Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.	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silver is a CHEMICAL	23086748_task0	Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of silver nanoparticles on the liver and hepatocytes in vitro.	[ "Effects", "of", "silver", "nanoparticles", "on", "the", "liver", "and", "hepatocytes", "in", "vitro", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
silver is a CHEMICAL	23086748_task1	Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please typing these entity words according to sentence: silver Options: CHEMICAL	[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of silver nanoparticles on the liver and hepatocytes in vitro.	[ "Effects", "of", "silver", "nanoparticles", "on", "the", "liver", "and", "hepatocytes", "in", "vitro", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
silver	23086748_task2	Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of silver nanoparticles on the liver and hepatocytes in vitro.	[ "Effects", "of", "silver", "nanoparticles", "on", "the", "liver", "and", "hepatocytes", "in", "vitro", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
granulocyte - macrophage colony - stimulating factor is a Protein, E - selectin is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein, regulatory elements is a Entity, GM - CSF is a Protein, E - selectin is a Protein, vascular cell adhesion molecule-1 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, promoter is a Entity, NF - kappa B is a Entity, tumor necrosis factor ( TNF)-alpha is a Protein, chromatin is a Entity, DNasel is a Protein, hypersensitive sites is a Entity, GM - CSF is a Protein, enhancer is a Entity, E - selectin is a Protein, promoter is a Entity	422_task0	Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.	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granulocyte - macrophage colony - stimulating factor is a Protein, E - selectin is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein, regulatory elements is a Entity, GM - CSF is a Protein, E - selectin is a Protein, vascular cell adhesion molecule-1 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, promoter is a Entity, NF - kappa B is a Entity, tumor necrosis factor ( TNF)-alpha is a Protein, chromatin is a Entity, DNasel is a Protein, hypersensitive sites is a Entity, GM - CSF is a Protein, enhancer is a Entity, E - selectin is a Protein, promoter is a Entity	422_task1	Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please typing these entity words according to sentence: granulocyte - macrophage colony - stimulating factor, E - selectin, granulocyte - macrophage colony - stimulating factor, GM - CSF, regulatory elements, GM - CSF, E - selectin, vascular cell adhesion molecule-1, VCAM-1, E - selectin, promoter, NF - kappa B, tumor necrosis factor ( TNF)-alpha, chromatin, DNasel, hypersensitive sites, GM - CSF, enhancer, E - selectin, promoter Options: Entity, Protein	[ "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.	[ "Regulation", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "and", "E", "-", "selectin", "expression", "in", "endothelial", "cells", "by", "cyclosporin", "A", "and", "the", "T", "-", "cell", "transcription", "factor", "NFAT", ".", "\n", "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "was", "originally", "described", "as", "a", "T", "-", "cell", "-", "specific", "transcription", "factor", "athat", "supported", "the", "activation", "of", "cytokine", "gene", "expression", "and", "mediated", "the", "immunoregulatory", "effects", "of", "cyclosporin", "A", "(", "CsA", ")", ".", "As", "we", "observed", "that", "activated", "endothelial", "cells", "also", "expressed", "NFAT", ",", "we", "tested", "the", "antiinflammatory", "properties", "of", "CsA", "in", "endothelial", "cells", ".", "Significantly", ",", "CsA", "completely", "suppressed", "the", "induction", "of", "NFAT", "in", "endothelial", "cells", "and", "inhibited", "the", "activity", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "(", "GM", "-", "CSF", ")", "gene", "regulatory", "elements", "that", "use", "NFAT", "by", "60", "%", ".", "CsA", "similarly", "mediated", "a", "reduction", "of", "up", "to", "65", "%", "in", "GM", "-", "CSF", "mRNA", "and", "protein", "expression", "in", "activated", "endothelial", "cells", ".", "CsA", "also", "suppressed", "E", "-", "selectin", ",", "but", "not", "vascular", "cell", "adhesion", "molecule-1", "(", "VCAM-1", ")", "expression", "in", "endothelial", "cells", ",", "even", "though", "the", "E", "-", "selectin", "promoter", "is", "activated", "by", "NF", "-", "kappa", "B", "rather", "than", "NFAT", ".", "Hence", ",", "induction", "of", "cell", "surface", "expression", "of", "this", "leukocyte", "adhesion", "molecule", "by", "tumor", "necrosis", "factor", "(", "TNF)-alpha", "was", "reduced", "by", "40", "%", "in", "the", "presence", "of", "CsA", ",", "and", "this", "was", "reflected", "by", "a", "29", "%", "decrease", "in", "neutrophil", "adhesion", ".", "The", "effects", "of", "CsA", "on", "endothelial", "cells", "were", "also", "detected", "at", "the", "chromatin", "structure", "level", ",", "as", "DNasel", "hypersensitive", "sites", "within", "both", "the", "GM", "-", "CSF", "enhancer", "and", "the", "E", "-", "selectin", "promoter", "were", "suppressed", "by", "CsA.", "This", "represents", "the", "first", "report", "of", "NFAT", "in", "endothelial", "cells", "and", "suggests", "mechanisms", "by", "which", "CsA", "could", "function", "as", "an", "antiinflammatory", "agent", ".", "\n" ]	[ "Protein", "Entity" ]
granulocyte - macrophage colony - stimulating factor, E - selectin, granulocyte - macrophage colony - stimulating factor, GM - CSF, regulatory elements, GM - CSF, E - selectin, vascular cell adhesion molecule-1, VCAM-1, E - selectin, promoter, NF - kappa B, tumor necrosis factor ( TNF)-alpha, chromatin, DNasel, hypersensitive sites, GM - CSF, enhancer, E - selectin, promoter	422_task2	Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.	[ "Regulation", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "and", "E", "-", "selectin", "expression", "in", "endothelial", "cells", "by", "cyclosporin", "A", "and", "the", "T", "-", "cell", "transcription", "factor", "NFAT", ".", "\n", "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "was", "originally", "described", "as", "a", "T", "-", "cell", "-", "specific", "transcription", "factor", "athat", "supported", "the", "activation", "of", "cytokine", "gene", "expression", "and", "mediated", "the", "immunoregulatory", "effects", "of", "cyclosporin", "A", "(", "CsA", ")", ".", "As", "we", "observed", "that", "activated", "endothelial", "cells", "also", "expressed", "NFAT", ",", "we", "tested", "the", "antiinflammatory", "properties", "of", "CsA", "in", "endothelial", "cells", ".", "Significantly", ",", "CsA", "completely", "suppressed", "the", "induction", "of", "NFAT", "in", "endothelial", "cells", "and", "inhibited", "the", "activity", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "(", "GM", "-", "CSF", ")", "gene", "regulatory", "elements", "that", "use", "NFAT", "by", "60", "%", ".", "CsA", "similarly", "mediated", "a", "reduction", "of", "up", "to", "65", "%", "in", "GM", "-", "CSF", "mRNA", "and", "protein", "expression", "in", "activated", "endothelial", "cells", ".", "CsA", "also", "suppressed", "E", "-", "selectin", ",", "but", "not", "vascular", "cell", "adhesion", "molecule-1", "(", "VCAM-1", ")", "expression", "in", "endothelial", "cells", ",", "even", "though", "the", "E", "-", "selectin", "promoter", "is", "activated", "by", "NF", "-", "kappa", "B", "rather", "than", "NFAT", ".", "Hence", ",", "induction", "of", "cell", "surface", "expression", "of", "this", "leukocyte", "adhesion", "molecule", "by", "tumor", "necrosis", "factor", "(", "TNF)-alpha", "was", "reduced", "by", "40", "%", "in", "the", "presence", "of", "CsA", ",", "and", "this", "was", "reflected", "by", "a", "29", "%", "decrease", "in", "neutrophil", "adhesion", ".", "The", "effects", "of", "CsA", "on", "endothelial", "cells", "were", "also", "detected", "at", "the", "chromatin", "structure", "level", ",", "as", "DNasel", "hypersensitive", "sites", "within", "both", "the", "GM", "-", "CSF", "enhancer", "and", "the", "E", "-", "selectin", "promoter", "were", "suppressed", "by", "CsA.", "This", "represents", "the", "first", "report", "of", "NFAT", "in", "endothelial", "cells", "and", "suggests", "mechanisms", "by", "which", "CsA", "could", "function", "as", "an", "antiinflammatory", "agent", ".", "\n" ]	[ "Protein", "Entity" ]
BCK1 is a Gene, MEKK is a DNA_family_or_group, BCK1 - 20 is a Gene, MKK1 is a Gene, MEK is a DNA_family_or_group, MPK1 is a Gene, MAP kinase is a DNA_family_or_group, PKC1 is a Gene, glc7 - 10 is a Gene, Pkc1p is a Individual_protein, ROM2 is a Gene, RHO2 is a Gene, HCS77 is a Gene, WSC1 is a Gene, SLG1 is a Gene, MID2 is a Gene, glc7 - 10 is a Gene	68_task0	Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, Gene, Individual_protein	[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]	Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.	[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]	[ "DNA_family_or_group", "Gene", "Individual_protein" ]
BCK1 is a Gene, MEKK is a DNA_family_or_group, BCK1 - 20 is a Gene, MKK1 is a Gene, MEK is a DNA_family_or_group, MPK1 is a Gene, MAP kinase is a DNA_family_or_group, PKC1 is a Gene, glc7 - 10 is a Gene, Pkc1p is a Individual_protein, ROM2 is a Gene, RHO2 is a Gene, HCS77 is a Gene, WSC1 is a Gene, SLG1 is a Gene, MID2 is a Gene, glc7 - 10 is a Gene	68_task1	Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please typing these entity words according to sentence: BCK1, MEKK, BCK1 - 20, MKK1, MEK, MPK1, MAP kinase, PKC1, glc7 - 10, Pkc1p, ROM2, RHO2, HCS77, WSC1, SLG1, MID2, glc7 - 10 Options: DNA_family_or_group, Gene, Individual_protein	[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]	Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.	[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]	[ "DNA_family_or_group", "Gene", "Individual_protein" ]
BCK1, MEKK, BCK1 - 20, MKK1, MEK, MPK1, MAP kinase, PKC1, glc7 - 10, Pkc1p, ROM2, RHO2, HCS77, WSC1, SLG1, MID2, glc7 - 10	68_task2	Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]	Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.	[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]	[ "DNA_family_or_group", "Gene", "Individual_protein" ]
actin is a Individual_protein, alpha - catenin is a Individual_protein, beta - catenin is a Individual_protein, plakoglobin is a Individual_protein, zyxin is a Individual_protein	534_task0	Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.	[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]	[ "Individual_protein" ]
actin is a Individual_protein, alpha - catenin is a Individual_protein, beta - catenin is a Individual_protein, plakoglobin is a Individual_protein, zyxin is a Individual_protein	534_task1	Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please typing these entity words according to sentence: actin, alpha - catenin, beta - catenin, plakoglobin, zyxin Options: Individual_protein	[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.	[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]	[ "Individual_protein" ]
actin, alpha - catenin, beta - catenin, plakoglobin, zyxin	534_task2	Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.	[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]	[ "Individual_protein" ]
child is a Species	506_task0	Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Species	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]	They are transmitted through sex contact, parenterally and from mother to child.	[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]	[ "Diseases", "Relation_Trigger", "Species" ]
child is a Species	506_task1	Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please typing these entity words according to sentence: child Options: Species	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]	They are transmitted through sex contact, parenterally and from mother to child.	[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]	[ "Diseases", "Relation_Trigger", "Species" ]
child	506_task2	Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]	They are transmitted through sex contact, parenterally and from mother to child.	[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]	[ "Diseases", "Relation_Trigger", "Species" ]
beta - globin is a Gene	449_task0	Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene	[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.	[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]	[ "Gene" ]
beta - globin is a Gene	449_task1	Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please typing these entity words according to sentence: beta - globin Options: Gene	[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.	[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]	[ "Gene" ]
beta - globin	449_task2	Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.	[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]	[ "Gene" ]
determination is an umlsterm, procalcitonin is an umlsterm, intensive care is an umlsterm, patients is an umlsterm, microbiological is an umlsterm, PCT is an umlsterm, ICU is an umlsterm, patients is an umlsterm, techniques is an umlsterm	IntensiveMedizin.80350124.eng.abstr_task0	Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .	[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]	[ "umlsterm" ]
determination is an umlsterm, procalcitonin is an umlsterm, intensive care is an umlsterm, patients is an umlsterm, microbiological is an umlsterm, PCT is an umlsterm, ICU is an umlsterm, patients is an umlsterm, techniques is an umlsterm	IntensiveMedizin.80350124.eng.abstr_task1	Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please typing these entity words according to sentence: determination, procalcitonin, intensive care, patients, microbiological, PCT, ICU, patients, techniques Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .	[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]	[ "umlsterm" ]
determination, procalcitonin, intensive care, patients, microbiological, PCT, ICU, patients, techniques	IntensiveMedizin.80350124.eng.abstr_task2	Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .	[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]	[ "umlsterm" ]
mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1-PGC-1alpha is a Complex, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha is a Gene_or_gene_product, mitochondrial is a Cellular_component, mammalian target of rapamycin is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, rapamycin is a Simple_chemical, mitochondrial is a Cellular_component, PGC-1alpha is a Gene_or_gene_product, oestrogen - related receptor alpha is a Gene_or_gene_product, nuclear is a Cellular_component, mitochondrial is a Cellular_component, oxygen is a Simple_chemical, yin - yang 1 is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1 is a Gene_or_gene_product, rapamycin is a Simple_chemical, mTOR is a Gene_or_gene_product, raptor is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component	180_task0	Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. 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Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.	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mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1-PGC-1alpha is a Complex, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha is a Gene_or_gene_product, mitochondrial is a Cellular_component, mammalian target of rapamycin is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, rapamycin is a Simple_chemical, mitochondrial is a Cellular_component, PGC-1alpha is a Gene_or_gene_product, oestrogen - related receptor alpha is a Gene_or_gene_product, nuclear is a Cellular_component, mitochondrial is a Cellular_component, oxygen is a Simple_chemical, yin - yang 1 is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1 is a Gene_or_gene_product, rapamycin is a Simple_chemical, mTOR is a Gene_or_gene_product, raptor is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component	180_task1	Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. Instructions: please typing these entity words according to sentence: mTOR, mitochondrial, YY1-PGC-1alpha, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha, mitochondrial, mammalian target of rapamycin, mTOR, mTOR, mitochondrial, mTOR, mitochondrial, mTOR, rapamycin, mitochondrial, PGC-1alpha, oestrogen - related receptor alpha, nuclear, mitochondrial, oxygen, yin - yang 1, YY1, mTOR, PGC-1alpha, YY1, mitochondrial, YY1, rapamycin, mTOR, raptor, YY1, mTOR, YY1, PGC-1alpha, mTOR, mitochondrial Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component	[ "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.	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mTOR, mitochondrial, YY1-PGC-1alpha, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha, mitochondrial, mammalian target of rapamycin, mTOR, mTOR, mitochondrial, mTOR, mitochondrial, mTOR, rapamycin, mitochondrial, PGC-1alpha, oestrogen - related receptor alpha, nuclear, mitochondrial, oxygen, yin - yang 1, YY1, mTOR, PGC-1alpha, YY1, mitochondrial, YY1, rapamycin, mTOR, raptor, YY1, mTOR, YY1, PGC-1alpha, mTOR, mitochondrial	180_task2	Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. Instructions: please extract entity words from the input sentence	[ "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.	[ "mTOR", "controls", "mitochondrial", "oxidative", "function", "through", "a", "YY1-PGC-1alpha", "transcriptional", "complex", ".", "\n", "Transcriptional", "complexes", "that", "contain", "peroxisome", "-", "proliferator", "-", "activated", "receptor", "coactivator", "(", "PGC)-1alpha", "control", "mitochondrial", "oxidative", "function", "to", "maintain", "energy", "homeostasis", "in", "response", "to", "nutrient", "and", "hormonal", "signals", ".", "An", "important", "component", "in", "the", "energy", "and", "nutrient", "pathways", "is", "mammalian", "target", "of", "rapamycin", "(", "mTOR", ")", ",", "a", "kinase", "that", "regulates", "cell", "growth", ",", "size", "and", "survival", ".", "However", ",", "it", "is", "unknown", "whether", "and", "how", "mTOR", "controls", "mitochondrial", "oxidative", "activities", ".", "Here", "we", "show", "that", "mTOR", "is", "necessary", "for", "the", "maintenance", "of", "mitochondrial", "oxidative", "function", ".", "In", "skeletal", "muscle", "tissues", "and", "cells", ",", "the", "mTOR", "inhibitor", "rapamycin", "decreased", "the", "gene", "expression", "of", "the", "mitochondrial", "transcriptional", "regulators", "PGC-1alpha", ",", "oestrogen", "-", "related", "receptor", "alpha", "and", "nuclear", "respiratory", "factors", ",", "resulting", "in", "a", "decrease", "in", "mitochondrial", "gene", "expression", "and", "oxygen", "consumption", ".", "Using", "computational", "genomics", ",", "we", "identified", "the", "transcription", "factor", "yin", "-", "yang", "1", "(", "YY1", ")", "as", "a", "common", "target", "of", "mTOR", "and", "PGC-1alpha", ".", "Knockdown", "of", "YY1", "caused", "a", "significant", "decrease", "in", "mitochondrial", "gene", "expression", "and", "in", "respiration", ",", "and", "YY1", "was", "required", "for", "rapamycin", "-", "dependent", "repression", "of", "those", "genes", ".", "Moreover", ",", "mTOR", "and", "raptor", "interacted", "with", "YY1", ",", "and", "inhibition", "of", "mTOR", "resulted", "in", "a", "failure", "of", "YY1", "to", "interact", "with", "and", "be", "coactivated", "by", "PGC-1alpha", ".", "We", "have", "therefore", "identified", "a", "mechanism", "by", "which", "a", "nutrient", "sensor", "(", "mTOR", ")", "balances", "energy", "metabolism", "by", "means", "of", "the", "transcriptional", "control", "of", "mitochondrial", "oxidative", "function", ".", "These", "results", "have", "important", "implications", "for", "our", "understanding", "of", "how", "these", "pathways", "might", "be", "altered", "in", "metabolic", "diseases", "and", "cancer", ".", "\n" ]	[ "Gene_or_gene_product", "Complex", "Cellular_component", "Simple_chemical" ]
Allergy or sensitivity is a Scope, corticosteroids is a Qualifier, drug hypersensitivity or intolerance is a Scope, adverse reaction is a Condition, Cortrosyn ™ or similar test reagents is a Scope	NCT02340169_exc_task0	Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Condition, Qualifier	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation	[ "Has", "other", "dermatological", "conditions", "that", "may", "interfere", "with", "clinical", "assessments", "\n", "Allergy", "or", "sensitivity", "to", "corticosteroids", "or", "any", "drug", "hypersensitivity", "or", "intolerance", "that", "would", "compromise", "patient", "safety", "or", "study", "results", "\n", "History", "of", "an", "adverse", "reaction", "to", "Cortrosyn", "™", "or", "similar", "test", "reagents", "\n", "Chronic", "infectious", "disease", ",", "system", "or", "organ", "disorder", "or", "other", "medical", "condition", "that", "would", "place", "patient", "at", "undue", "risk", "by", "study", "participation", "\n" ]	[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]
Allergy or sensitivity is a Scope, corticosteroids is a Qualifier, drug hypersensitivity or intolerance is a Scope, adverse reaction is a Condition, Cortrosyn ™ or similar test reagents is a Scope	NCT02340169_exc_task1	Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please typing these entity words according to sentence: Allergy or sensitivity, corticosteroids, drug hypersensitivity or intolerance, adverse reaction, Cortrosyn ™ or similar test reagents Options: Scope, Condition, Qualifier	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation	[ "Has", "other", "dermatological", "conditions", "that", "may", "interfere", "with", "clinical", "assessments", "\n", "Allergy", "or", "sensitivity", "to", "corticosteroids", "or", "any", "drug", "hypersensitivity", "or", "intolerance", "that", "would", "compromise", "patient", "safety", "or", "study", "results", "\n", "History", "of", "an", "adverse", "reaction", "to", "Cortrosyn", "™", "or", "similar", "test", "reagents", "\n", "Chronic", "infectious", "disease", ",", "system", "or", "organ", "disorder", "or", "other", "medical", "condition", "that", "would", "place", "patient", "at", "undue", "risk", "by", "study", "participation", "\n" ]	[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]
Allergy or sensitivity, corticosteroids, drug hypersensitivity or intolerance, adverse reaction, Cortrosyn ™ or similar test reagents	NCT02340169_exc_task2	Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation	[ "Has", "other", "dermatological", "conditions", "that", "may", "interfere", "with", "clinical", "assessments", "\n", "Allergy", "or", "sensitivity", "to", "corticosteroids", "or", "any", "drug", "hypersensitivity", "or", "intolerance", "that", "would", "compromise", "patient", "safety", "or", "study", "results", "\n", "History", "of", "an", "adverse", "reaction", "to", "Cortrosyn", "™", "or", "similar", "test", "reagents", "\n", "Chronic", "infectious", "disease", ",", "system", "or", "organ", "disorder", "or", "other", "medical", "condition", "that", "would", "place", "patient", "at", "undue", "risk", "by", "study", "participation", "\n" ]	[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]
RAR alpha is a Protein, hRAR alpha is a Protein, retinoid - X receptor alpha is a Protein, hRXR alpha is a Protein, RXR alpha is a Protein, RXR alpha is a Protein, RAR alpha is a Protein	448_task0	Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.	[ "The", "regulation", "of", "HIV", "by", "retinoic", "acid", "correlates", "with", "cellular", "expression", "of", "the", "retinoic", "acid", "receptors", ".", "\n", "OBJECTIVES", ":", "To", "analyze", "the", "effect", "of", "retinoic", "acids", "(", "RA", ")", "on", "HIV-1", "expression", "and", "correlate", "this", "effect", "with", "expression", "levels", "of", "RA", "receptors", "(", "RARs", ")", "in", "T", "-", "lymphoid", "and", "monocytoid", "cell", "lines", ".", "DESIGN", "AND", "METHODS", ":", "The", "effect", "of", "all", "-", "trans", "and", "9-cis", "RA", "on", "HIV-1", "production", "in", "T", "-", "lymphoid", "(", "H9", ",", "CEM", ")", "and", "monocytoid", "(", "U937,THP-1", ")", "cell", "lines", "was", "measured", "during", "acute", "and", "chronic", "infection", ".", "The", "expression", "levels", "of", "human", "RAR", "alpha", "(", "hRAR", "alpha", ",", "receptor", "for", "all", "-", "trans", "RA", ")", "and", "the", "human", "retinoid", "-", "X", "receptor", "alpha", "(", "hRXR", "alpha", "receptor", "for", "9-cis", "RA", ")", "were", "determined", "by", "Northern", "blot", "analysis", ".", "RESULTS", ":", "Both", "all", "-", "trans", "and", "9-cis", "RA", "inhibited", "virus", "replication", "in", "HIV-1", "IIIB", "-", "infected", "monocytoid", "cells", ",", "in", "the", "presence", "and", "absence", "of", "the", "co", "-", "stimulatory", "agent", "phorbol", "myristate", "acetate", "(", "PMA", ")", ".", "The", "retinoids", "had", "weak", "or", "no", "stimulatory", "effects", "on", "HIV", "production", "by", "T", "-", "cell", "lines", ".", "HIV", "production", "by", "PMA", "-", "stimulated", "T", "-", "cell", "lines", "was", "inhibited", "by", "these", "retinoids", ".", "The", "9-cis", "RA", "was", "generally", "more", "effective", "than", "all", "-", "trans", "RA", "in", "inhibiting", "HIV", "production", "and", "in", "combination", "generally", "more", "effective", "than", "the", "single", "agents", "alone", ".", "Human", "RAR", "alpha", "was", "expressed", "in", "H9", ",", "U937", "and", "THP-1", "cells", ",", "but", "almost", "undetectable", "in", "CEM", "cells", ".", "Human", "RXR", "alpha", "was", "significantly", "expressed", "in", "U937", "and", "THP-1", "cells", ",", "weakly", "expressed", "in", "H9", "cells", "and", "not", "detectable", "in", "CEM", "cells", ".", "After", "stimulation", "by", "PMA", ",", "RXR", "alpha", "expression", "increased", "in", "H9", "and", "U937", "cells", "but", "not", "in", "CEM", "cells", ".", "Human", "RAR", "alpha", "expression", "was", "unchanged", "in", "H9", "and", "CEM", "cells", ",", "and", "elevated", "in", "U937", "cells", ",", "after", "PMA", "stimulation", ".", "CONCLUSION", ":", "The", "effect", "of", "RA", "on", "HIV-1", "expression", "was", "cell", "-", "type", "-", "dependent", "and", "partially", "correlated", "with", "cellular", "expression", "of", "RARs", ".", "Endogenous", "or", "exogenously", "administered", "RA", "may", "have", "a", "significant", "role", "in", "HIV", "regulation", "." ]	[ "Protein" ]
RAR alpha is a Protein, hRAR alpha is a Protein, retinoid - X receptor alpha is a Protein, hRXR alpha is a Protein, RXR alpha is a Protein, RXR alpha is a Protein, RAR alpha is a Protein	448_task1	Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please typing these entity words according to sentence: RAR alpha, hRAR alpha, retinoid - X receptor alpha, hRXR alpha, RXR alpha, RXR alpha, RAR alpha Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.	[ "The", "regulation", "of", "HIV", "by", "retinoic", "acid", "correlates", "with", "cellular", "expression", "of", "the", "retinoic", "acid", "receptors", ".", "\n", "OBJECTIVES", ":", "To", "analyze", "the", "effect", "of", "retinoic", "acids", "(", "RA", ")", "on", "HIV-1", "expression", "and", "correlate", "this", "effect", "with", "expression", "levels", "of", "RA", "receptors", "(", "RARs", ")", "in", "T", "-", "lymphoid", "and", "monocytoid", "cell", "lines", ".", "DESIGN", "AND", "METHODS", ":", "The", "effect", "of", "all", "-", "trans", "and", "9-cis", "RA", "on", "HIV-1", "production", "in", "T", "-", "lymphoid", "(", "H9", ",", "CEM", ")", "and", "monocytoid", "(", "U937,THP-1", ")", "cell", "lines", "was", "measured", "during", "acute", "and", "chronic", "infection", ".", "The", "expression", "levels", "of", "human", "RAR", "alpha", "(", "hRAR", "alpha", ",", "receptor", "for", "all", "-", "trans", "RA", ")", "and", "the", "human", "retinoid", "-", "X", "receptor", "alpha", "(", "hRXR", "alpha", "receptor", "for", "9-cis", "RA", ")", "were", "determined", "by", "Northern", "blot", "analysis", ".", "RESULTS", ":", "Both", "all", "-", "trans", "and", "9-cis", "RA", "inhibited", "virus", "replication", "in", "HIV-1", "IIIB", "-", "infected", "monocytoid", "cells", ",", "in", "the", "presence", "and", "absence", "of", "the", "co", "-", "stimulatory", "agent", "phorbol", "myristate", "acetate", "(", "PMA", ")", ".", "The", "retinoids", "had", "weak", "or", "no", "stimulatory", "effects", "on", "HIV", "production", "by", "T", "-", "cell", "lines", ".", "HIV", "production", "by", "PMA", "-", "stimulated", "T", "-", "cell", "lines", "was", "inhibited", "by", "these", "retinoids", ".", "The", "9-cis", "RA", "was", "generally", "more", "effective", "than", "all", "-", "trans", "RA", "in", "inhibiting", "HIV", "production", "and", "in", "combination", "generally", "more", "effective", "than", "the", "single", "agents", "alone", ".", "Human", "RAR", "alpha", "was", "expressed", "in", "H9", ",", "U937", "and", "THP-1", "cells", ",", "but", "almost", "undetectable", "in", "CEM", "cells", ".", "Human", "RXR", "alpha", "was", "significantly", "expressed", "in", "U937", "and", "THP-1", "cells", ",", "weakly", "expressed", "in", "H9", "cells", "and", "not", "detectable", "in", "CEM", "cells", ".", "After", "stimulation", "by", "PMA", ",", "RXR", "alpha", "expression", "increased", "in", "H9", "and", "U937", "cells", "but", "not", "in", "CEM", "cells", ".", "Human", "RAR", "alpha", "expression", "was", "unchanged", "in", "H9", "and", "CEM", "cells", ",", "and", "elevated", "in", "U937", "cells", ",", "after", "PMA", "stimulation", ".", "CONCLUSION", ":", "The", "effect", "of", "RA", "on", "HIV-1", "expression", "was", "cell", "-", "type", "-", "dependent", "and", "partially", "correlated", "with", "cellular", "expression", "of", "RARs", ".", "Endogenous", "or", "exogenously", "administered", "RA", "may", "have", "a", "significant", "role", "in", "HIV", "regulation", "." ]	[ "Protein" ]
RAR alpha, hRAR alpha, retinoid - X receptor alpha, hRXR alpha, RXR alpha, RXR alpha, RAR alpha	448_task2	Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.	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histopathology is an umlsterm, cartilage is an umlsterm, growth plate is an umlsterm, differential diagnosis is an umlsterm, atelosteogenesis is an umlsterm	DerPathologe.80190379.eng.abstr_task0	Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .	[ "The", "authors", "describe", "the", "histopathology", "of", "the", "resting", "cartilage", "and", "the", "growth", "plate", "in", "a", "case", "of", "diastrophic", "dysplasia", "and", "review", "the", "differential", "diagnosis", "with", "pseudodiastrophic", "dysplasia", "and", "atelosteogenesis", "type", "II", "." ]	[ "umlsterm" ]
histopathology is an umlsterm, cartilage is an umlsterm, growth plate is an umlsterm, differential diagnosis is an umlsterm, atelosteogenesis is an umlsterm	DerPathologe.80190379.eng.abstr_task1	Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please typing these entity words according to sentence: histopathology, cartilage, growth plate, differential diagnosis, atelosteogenesis Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .	[ "The", "authors", "describe", "the", "histopathology", "of", "the", "resting", "cartilage", "and", "the", "growth", "plate", "in", "a", "case", "of", "diastrophic", "dysplasia", "and", "review", "the", "differential", "diagnosis", "with", "pseudodiastrophic", "dysplasia", "and", "atelosteogenesis", "type", "II", "." ]	[ "umlsterm" ]
histopathology, cartilage, growth plate, differential diagnosis, atelosteogenesis	DerPathologe.80190379.eng.abstr_task2	Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .	[ "The", "authors", "describe", "the", "histopathology", "of", "the", "resting", "cartilage", "and", "the", "growth", "plate", "in", "a", "case", "of", "diastrophic", "dysplasia", "and", "review", "the", "differential", "diagnosis", "with", "pseudodiastrophic", "dysplasia", "and", "atelosteogenesis", "type", "II", "." ]	[ "umlsterm" ]
clonidine hydrochloride is a IUPAC, clonidine hydrochloride is a IUPAC, noradrenaline is a TRIVIAL, clonidine is a TRIVIAL, group is a MODIFIER, clonidine hydrochloride is a IUPAC, dopamine is a TRIVIAL	example-5_task0	Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MODIFIER, TRIVIAL, IUPAC	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "B-MODIFIER", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.	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clonidine hydrochloride is a IUPAC, clonidine hydrochloride is a IUPAC, noradrenaline is a TRIVIAL, clonidine is a TRIVIAL, group is a MODIFIER, clonidine hydrochloride is a IUPAC, dopamine is a TRIVIAL	example-5_task1	Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please typing these entity words according to sentence: clonidine hydrochloride, clonidine hydrochloride, noradrenaline, clonidine, group, clonidine hydrochloride, dopamine Options: MODIFIER, TRIVIAL, IUPAC	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "B-MODIFIER", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.	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clonidine hydrochloride, clonidine hydrochloride, noradrenaline, clonidine, group, clonidine hydrochloride, dopamine	example-5_task2	Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "B-MODIFIER", "O", "O", "O", "O", "O", "O", "O", "O", "B-IUPAC", "I-IUPAC", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TRIVIAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.	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Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, T cell antigen receptor is a Entity, nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein	546_task0	Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.	[ "HIV-1", "Nef", "leads", "to", "inhibition", "or", "activation", "of", "T", "cells", "depending", "on", "its", "intracellular", "localization", ".", "\n", "Nef", "of", "primate", "lentiviruses", "is", "required", "for", "viremia", "and", "progression", "to", "AIDS", "in", "monkeys", ".", "Negative", ",", "positive", ",", "and", "no", "effects", "of", "Nef", "have", "also", "been", "reported", "on", "viral", "replication", "in", "cells", ".", "To", "reconcile", "these", "observations", ",", "we", "expressed", "a", "hybrid", "CD8-Nef", "protein", "in", "Jurkat", "cells", ".", "Two", "opposite", "phenotypes", "were", "found", ",", "which", "depended", "on", "the", "intracellular", "localization", "of", "Nef", ".", "Expressed", "in", "the", "cytoplasm", "or", "on", "the", "cell", "surface", ",", "the", "chimera", "inhibited", "or", "activated", "early", "signaling", "events", "from", "the", "T", "cell", "antigen", "receptor", ".", "Activated", "Jurkat", "cells", "died", "by", "apoptosis", ",", "and", "only", "cells", "with", "mutated", "nef", "genes", "expressing", "truncated", "Nefs", "survived", ",", "which", "rendered", "Nef", "nonfunctional", ".", "These", "mutations", "paralleled", "those", "in", "other", "viral", "strains", "passaged", "in", "vitro", ".", "Not", "only", "do", "these", "positional", "effects", "of", "Nef", "reconcile", "diverse", "phenotypes", "of", "Nef", "and", "suggest", "a", "role", "for", "its", "N", "-", "terminal", "myristylation", ",", "but", "they", "also", "explain", "effects", "of", "Nef", "in", "HIV", "infection", "and", "progression", "to", "AIDS", ".", "\n" ]	[ "Entity", "Protein" ]
Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, T cell antigen receptor is a Entity, nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein	546_task1	Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please typing these entity words according to sentence: Nef, Nef, Nef, Nef, T cell antigen receptor, nef, Nef, Nef, Nef, Nef Options: Entity, Protein	[ "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.	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Nef, Nef, Nef, Nef, T cell antigen receptor, nef, Nef, Nef, Nef, Nef	546_task2	Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please extract entity words from the input sentence	[ "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.	[ "HIV-1", "Nef", "leads", "to", "inhibition", "or", "activation", "of", "T", "cells", "depending", "on", "its", "intracellular", "localization", ".", "\n", "Nef", "of", "primate", "lentiviruses", "is", "required", "for", "viremia", "and", "progression", "to", "AIDS", "in", "monkeys", ".", "Negative", ",", "positive", ",", "and", "no", "effects", "of", "Nef", "have", "also", "been", "reported", "on", "viral", "replication", "in", "cells", ".", "To", "reconcile", "these", "observations", ",", "we", "expressed", "a", "hybrid", "CD8-Nef", "protein", "in", "Jurkat", "cells", ".", "Two", "opposite", "phenotypes", "were", "found", ",", "which", "depended", "on", "the", "intracellular", "localization", "of", "Nef", ".", "Expressed", "in", "the", "cytoplasm", "or", "on", "the", "cell", "surface", ",", "the", "chimera", "inhibited", "or", "activated", "early", "signaling", "events", "from", "the", "T", "cell", "antigen", "receptor", ".", "Activated", "Jurkat", "cells", "died", "by", "apoptosis", ",", "and", "only", "cells", "with", "mutated", "nef", "genes", "expressing", "truncated", "Nefs", "survived", ",", "which", "rendered", "Nef", "nonfunctional", ".", "These", "mutations", "paralleled", "those", "in", "other", "viral", "strains", "passaged", "in", "vitro", ".", "Not", "only", "do", "these", "positional", "effects", "of", "Nef", "reconcile", "diverse", "phenotypes", "of", "Nef", "and", "suggest", "a", "role", "for", "its", "N", "-", "terminal", "myristylation", ",", "but", "they", "also", "explain", "effects", "of", "Nef", "in", "HIV", "infection", "and", "progression", "to", "AIDS", ".", "\n" ]	[ "Entity", "Protein" ]
Behandlung is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, Tumorvolumen is an umlsterm, Prognosefaktoren is an umlsterm, Beckenrezidiv is an umlsterm, Tumorbiologische is an umlsterm, Marker is an umlsterm, Nachweismethoden is an umlsterm, Therapieplanung is an umlsterm, Prognose is an umlsterm, Rolle is an umlsterm, Therapieprinzipien is an umlsterm, Hysterektomie is an umlsterm, Beckens is an umlsterm, Rolle is an umlsterm, Chemotherapie is an umlsterm, Karzinomen is an umlsterm	DerPathologe.90200042.ger.abstr_task0	Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .	[ "Die", "Behandlung", "des", "histologisch", "gesicherten", "Zervixkarzinoms", "erfolgt", "unabhaengig", "vom", "histologischen", "Typ", "stadienspezifisch", ".", "Das", "klinische", "Staging", "ist", "fuer", "die", "Wahl", "der", "primaeren", "Therapie", "des", "Zervixkarzinoms", "entscheidend", ".", "Nach", "operativer", "Therapie", "ist", "die", "morphologische", "Begutachtung", "des", "Operationspraeparates", "die", "Grundlage", "fuer", "das", "endgueltige", "Staging", ",", "das", "weitere", "postoperative", "Vorgehen", "und", "die", "Prognose", ".", "Besondere", "Bedeutung", "haben", "Stroma-", "und", "Gefaessinvasion", ",", "Tumorvolumen", "und", "Resektatrandbefund", ",", "da", "diese", "Parameter", "als", "die", "wichtigsten", "morphologischen", "Prognosefaktoren", "(", "Beckenrezidiv", "Fernmetastasierung", ",", ",", "Ueberleben", ")", "gelten", ".", "Tumorbiologische", "Marker", "und", "Nachweismethoden", "spielen", "fuer", "die", "Therapieplanung", "und", "Prognose", "bisher", "keine", "Rolle", ".", "Klassische", "Therapieprinzipien", "sind", "die", "radikale", "Hysterektomie", "nach", "Wertheim", "-", "Meigs", "und", "die", "primaere", "oder", "adjuvante", "Bestrahlung", "des", "Beckens", ".", "Die", "Rolle", "der", "Chemotherapie", "ist", "noch", "zu", "definieren", ".", "Bei", "mikroinvasiven", "Karzinomen", "ist", "ein", "differenziertes", ",", "weniger", "invasives", "Vorgehen", "in", "Abhaengigkeit", "von", "den", "Faktoren", "Stromainvasion", ",", "Gefaessinvasion", "und", "Resektatrandbefund", "moeglich", "." ]	[ "umlsterm" ]
Behandlung is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, Tumorvolumen is an umlsterm, Prognosefaktoren is an umlsterm, Beckenrezidiv is an umlsterm, Tumorbiologische is an umlsterm, Marker is an umlsterm, Nachweismethoden is an umlsterm, Therapieplanung is an umlsterm, Prognose is an umlsterm, Rolle is an umlsterm, Therapieprinzipien is an umlsterm, Hysterektomie is an umlsterm, Beckens is an umlsterm, Rolle is an umlsterm, Chemotherapie is an umlsterm, Karzinomen is an umlsterm	DerPathologe.90200042.ger.abstr_task1	Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please typing these entity words according to sentence: Behandlung, Therapie, Therapie, Prognose, Tumorvolumen, Prognosefaktoren, Beckenrezidiv, Tumorbiologische, Marker, Nachweismethoden, Therapieplanung, Prognose, Rolle, Therapieprinzipien, Hysterektomie, Beckens, Rolle, Chemotherapie, Karzinomen Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .	[ "Die", "Behandlung", "des", "histologisch", "gesicherten", "Zervixkarzinoms", "erfolgt", "unabhaengig", "vom", "histologischen", "Typ", "stadienspezifisch", ".", "Das", "klinische", "Staging", "ist", "fuer", "die", "Wahl", "der", "primaeren", "Therapie", "des", "Zervixkarzinoms", "entscheidend", ".", "Nach", "operativer", "Therapie", "ist", "die", "morphologische", "Begutachtung", "des", "Operationspraeparates", "die", "Grundlage", "fuer", "das", "endgueltige", "Staging", ",", "das", "weitere", "postoperative", "Vorgehen", "und", "die", "Prognose", ".", "Besondere", "Bedeutung", "haben", "Stroma-", "und", "Gefaessinvasion", ",", "Tumorvolumen", "und", "Resektatrandbefund", ",", "da", "diese", "Parameter", "als", "die", "wichtigsten", "morphologischen", "Prognosefaktoren", "(", "Beckenrezidiv", "Fernmetastasierung", ",", ",", "Ueberleben", ")", "gelten", ".", "Tumorbiologische", "Marker", "und", "Nachweismethoden", "spielen", "fuer", "die", "Therapieplanung", "und", "Prognose", "bisher", "keine", "Rolle", ".", "Klassische", "Therapieprinzipien", "sind", "die", "radikale", "Hysterektomie", "nach", "Wertheim", "-", "Meigs", "und", "die", "primaere", "oder", "adjuvante", "Bestrahlung", "des", "Beckens", ".", "Die", "Rolle", "der", "Chemotherapie", "ist", "noch", "zu", "definieren", ".", "Bei", "mikroinvasiven", "Karzinomen", "ist", "ein", "differenziertes", ",", "weniger", "invasives", "Vorgehen", "in", "Abhaengigkeit", "von", "den", "Faktoren", "Stromainvasion", ",", "Gefaessinvasion", "und", "Resektatrandbefund", "moeglich", "." ]	[ "umlsterm" ]
Behandlung, Therapie, Therapie, Prognose, Tumorvolumen, Prognosefaktoren, Beckenrezidiv, Tumorbiologische, Marker, Nachweismethoden, Therapieplanung, Prognose, Rolle, Therapieprinzipien, Hysterektomie, Beckens, Rolle, Chemotherapie, Karzinomen	DerPathologe.90200042.ger.abstr_task2	Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .	[ "Die", "Behandlung", "des", "histologisch", "gesicherten", "Zervixkarzinoms", "erfolgt", "unabhaengig", "vom", "histologischen", "Typ", "stadienspezifisch", ".", "Das", "klinische", "Staging", "ist", "fuer", "die", "Wahl", "der", "primaeren", "Therapie", "des", "Zervixkarzinoms", "entscheidend", ".", "Nach", "operativer", "Therapie", "ist", "die", "morphologische", "Begutachtung", "des", "Operationspraeparates", "die", "Grundlage", "fuer", "das", "endgueltige", "Staging", ",", "das", "weitere", "postoperative", "Vorgehen", "und", "die", "Prognose", ".", "Besondere", "Bedeutung", "haben", "Stroma-", "und", "Gefaessinvasion", ",", "Tumorvolumen", "und", "Resektatrandbefund", ",", "da", "diese", "Parameter", "als", "die", "wichtigsten", "morphologischen", "Prognosefaktoren", "(", "Beckenrezidiv", "Fernmetastasierung", ",", ",", "Ueberleben", ")", "gelten", ".", "Tumorbiologische", "Marker", "und", "Nachweismethoden", "spielen", "fuer", "die", "Therapieplanung", "und", "Prognose", "bisher", "keine", "Rolle", ".", "Klassische", "Therapieprinzipien", "sind", "die", "radikale", "Hysterektomie", "nach", "Wertheim", "-", "Meigs", "und", "die", "primaere", "oder", "adjuvante", "Bestrahlung", "des", "Beckens", ".", "Die", "Rolle", "der", "Chemotherapie", "ist", "noch", "zu", "definieren", ".", "Bei", "mikroinvasiven", "Karzinomen", "ist", "ein", "differenziertes", ",", "weniger", "invasives", "Vorgehen", "in", "Abhaengigkeit", "von", "den", "Faktoren", "Stromainvasion", ",", "Gefaessinvasion", "und", "Resektatrandbefund", "moeglich", "." ]	[ "umlsterm" ]
Membrane receptors is a protein_family_or_group, aldosterone is a lipid, mineralocorticoid action is an other_name	87365_task0	Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_family_or_group, lipid, other_name	[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]	Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.	[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]	[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]
Membrane receptors is a protein_family_or_group, aldosterone is a lipid, mineralocorticoid action is an other_name	87365_task1	Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please typing these entity words according to sentence: Membrane receptors, aldosterone, mineralocorticoid action Options: protein_family_or_group, lipid, other_name	[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]	Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.	[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]	[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]
Membrane receptors, aldosterone, mineralocorticoid action	87365_task2	Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please extract entity words from the input sentence	[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]	Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.	[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]	[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]
ichthyosis vulgaris is an umlsterm, ointment is an umlsterm, child is an umlsterm, salicylic acid is an umlsterm, body weight is an umlsterm, period is an umlsterm, patient is an umlsterm, hospital is an umlsterm, family doctor is an umlsterm, hyperventilation is an umlsterm, vomiting is an umlsterm, tinnitus is an umlsterm, vertigo is an umlsterm, Salicylate is an umlsterm, intoxication is an umlsterm, acidosis is an umlsterm, anion gap is an umlsterm, overcompensation is an umlsterm, diagnosis is an umlsterm, salicylate is an umlsterm, therapeutic is an umlsterm, diuresis is an umlsterm, sodium bicarbonate is an umlsterm, haemodialysis is an umlsterm, salicylate is an umlsterm, values is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, deficiencies is an umlsterm, Fecal incontinence is an umlsterm, ptosis is an umlsterm, strabismus is an umlsterm, right is an umlsterm, pathogenesis is an umlsterm, salicylate is an umlsterm, toxicity is an umlsterm, need is an umlsterm, therapies is an umlsterm, ichthyosis vulgaris is an umlsterm	DerHautarzt.60470624.eng.abstr_task0	Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .	[ "In", "a", "7-year", "-", "old", "boy", ",", "ichthyosis", "vulgaris", "was", "treated", "with", "a", "10", "%", "ointment", "for", "application", "over", "a", "large", "area", "of", "the", "body", "surface", ".", "In", "this", "way", ",", "the", "child", "received", "400", "g", "salicylic", "acid", "(", "0.6", "g", "/", "kg", "body", "weight", "per", "day", ")", "percutaneously", "over", "a", "period", "of", "4", "weeks", ".", "The", "patient", "was", "referred", "to", "hospital", "by", "the", "family", "doctor", ":", "he", "was", "in", "a", "deep", "somnolent", "state", ",", "apparently", "caused", "by", "hyperventilation", "following", "wheezing", ",", "vomiting", ",", "tinnitus", "and", "vertigo", ".", "Salicylate", "intoxication", "was", "suspected", "because", "of", "metabolic", "acidosis", ",", "an", "anion", "gap", "and", "respiratory", "overcompensation", ".", "The", "diagnosis", "was", "confirmed", "by", "a", "serum", "salicylate", "level", "of", "985", "µg", "/", "ml", "(", "therapeutic", "level", "150", "-", "300", "µg", "/", "ml", ")", ".", "Following", "forced", "diuresis", "and", "alkalization", "with", "sodium", "bicarbonate", ",", "haemodialysis", "was", "unnecessary", ".", "As", "the", "salicylate", "level", "declined", "to", "values", "within", "the", "therapeutic", "range", ",", "the", "patient", "started", "to", "recover", "conciousness", ",", "waking", "on", "the", "4th", "day", ".", "By", "day", "6", "there", "were", "still", "obvious", "neurological", "deficiencies", ".", "Fecal", "incontinence", ",", "bilateral", "ptosis", "and", "intermittent", "diverging", "strabismus", "on", "the", "right", "persisted", "for", "some", "weeks", ".", "It", "was", "6", "months", "before", "complete", "neurological", "resolution", "was", "achieved", ".", "The", "pathogenesis", "of", "salicylate", "toxicity", "and", "the", "need", "for", "safer", "therapies", "for", "ichthyosis", "vulgaris", "are", "discussed", "." ]	[ "umlsterm" ]
ichthyosis vulgaris is an umlsterm, ointment is an umlsterm, child is an umlsterm, salicylic acid is an umlsterm, body weight is an umlsterm, period is an umlsterm, patient is an umlsterm, hospital is an umlsterm, family doctor is an umlsterm, hyperventilation is an umlsterm, vomiting is an umlsterm, tinnitus is an umlsterm, vertigo is an umlsterm, Salicylate is an umlsterm, intoxication is an umlsterm, acidosis is an umlsterm, anion gap is an umlsterm, overcompensation is an umlsterm, diagnosis is an umlsterm, salicylate is an umlsterm, therapeutic is an umlsterm, diuresis is an umlsterm, sodium bicarbonate is an umlsterm, haemodialysis is an umlsterm, salicylate is an umlsterm, values is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, deficiencies is an umlsterm, Fecal incontinence is an umlsterm, ptosis is an umlsterm, strabismus is an umlsterm, right is an umlsterm, pathogenesis is an umlsterm, salicylate is an umlsterm, toxicity is an umlsterm, need is an umlsterm, therapies is an umlsterm, ichthyosis vulgaris is an umlsterm	DerHautarzt.60470624.eng.abstr_task1	Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please typing these entity words according to sentence: ichthyosis vulgaris, ointment, child, salicylic acid, body weight, period, patient, hospital, family doctor, hyperventilation, vomiting, tinnitus, vertigo, Salicylate, intoxication, acidosis, anion gap, overcompensation, diagnosis, salicylate, therapeutic, diuresis, sodium bicarbonate, haemodialysis, salicylate, values, therapeutic, patient, deficiencies, Fecal incontinence, ptosis, strabismus, right, pathogenesis, salicylate, toxicity, need, therapies, ichthyosis vulgaris Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .	[ "In", "a", "7-year", "-", "old", "boy", ",", "ichthyosis", "vulgaris", "was", "treated", "with", "a", "10", "%", "ointment", "for", "application", "over", "a", "large", "area", "of", "the", "body", "surface", ".", "In", "this", "way", ",", "the", "child", "received", "400", "g", "salicylic", "acid", "(", "0.6", "g", "/", "kg", "body", "weight", "per", "day", ")", "percutaneously", "over", "a", "period", "of", "4", "weeks", ".", "The", "patient", "was", "referred", "to", "hospital", "by", "the", "family", "doctor", ":", "he", "was", "in", "a", "deep", "somnolent", "state", ",", "apparently", "caused", "by", "hyperventilation", "following", "wheezing", ",", "vomiting", ",", "tinnitus", "and", "vertigo", ".", "Salicylate", "intoxication", "was", "suspected", "because", "of", "metabolic", "acidosis", ",", "an", "anion", "gap", "and", "respiratory", "overcompensation", ".", "The", "diagnosis", "was", "confirmed", "by", "a", "serum", "salicylate", "level", "of", "985", "µg", "/", "ml", "(", "therapeutic", "level", "150", "-", "300", "µg", "/", "ml", ")", ".", "Following", "forced", "diuresis", "and", "alkalization", "with", "sodium", "bicarbonate", ",", "haemodialysis", "was", "unnecessary", ".", "As", "the", "salicylate", "level", "declined", "to", "values", "within", "the", "therapeutic", "range", ",", "the", "patient", "started", "to", "recover", "conciousness", ",", "waking", "on", "the", "4th", "day", ".", "By", "day", "6", "there", "were", "still", "obvious", "neurological", "deficiencies", ".", "Fecal", "incontinence", ",", "bilateral", "ptosis", "and", "intermittent", "diverging", "strabismus", "on", "the", "right", "persisted", "for", "some", "weeks", ".", "It", "was", "6", "months", "before", "complete", "neurological", "resolution", "was", "achieved", ".", "The", "pathogenesis", "of", "salicylate", "toxicity", "and", "the", "need", "for", "safer", "therapies", "for", "ichthyosis", "vulgaris", "are", "discussed", "." ]	[ "umlsterm" ]
ichthyosis vulgaris, ointment, child, salicylic acid, body weight, period, patient, hospital, family doctor, hyperventilation, vomiting, tinnitus, vertigo, Salicylate, intoxication, acidosis, anion gap, overcompensation, diagnosis, salicylate, therapeutic, diuresis, sodium bicarbonate, haemodialysis, salicylate, values, therapeutic, patient, deficiencies, Fecal incontinence, ptosis, strabismus, right, pathogenesis, salicylate, toxicity, need, therapies, ichthyosis vulgaris	DerHautarzt.60470624.eng.abstr_task2	Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .	[ "In", "a", "7-year", "-", "old", "boy", ",", "ichthyosis", "vulgaris", "was", "treated", "with", "a", "10", "%", "ointment", "for", "application", "over", "a", "large", "area", "of", "the", "body", "surface", ".", "In", "this", "way", ",", "the", "child", "received", "400", "g", "salicylic", "acid", "(", "0.6", "g", "/", "kg", "body", "weight", "per", "day", ")", "percutaneously", "over", "a", "period", "of", "4", "weeks", ".", "The", "patient", "was", "referred", "to", "hospital", "by", "the", "family", "doctor", ":", "he", "was", "in", "a", "deep", "somnolent", "state", ",", "apparently", "caused", "by", "hyperventilation", "following", "wheezing", ",", "vomiting", ",", "tinnitus", "and", "vertigo", ".", "Salicylate", "intoxication", "was", "suspected", "because", "of", "metabolic", "acidosis", ",", "an", "anion", "gap", "and", "respiratory", "overcompensation", ".", "The", "diagnosis", "was", "confirmed", "by", "a", "serum", "salicylate", "level", "of", "985", "µg", "/", "ml", "(", "therapeutic", "level", "150", "-", "300", "µg", "/", "ml", ")", ".", "Following", "forced", "diuresis", "and", "alkalization", "with", "sodium", "bicarbonate", ",", "haemodialysis", "was", "unnecessary", ".", "As", "the", "salicylate", "level", "declined", "to", "values", "within", "the", "therapeutic", "range", ",", "the", "patient", "started", "to", "recover", "conciousness", ",", "waking", "on", "the", "4th", "day", ".", "By", "day", "6", "there", "were", "still", "obvious", "neurological", "deficiencies", ".", "Fecal", "incontinence", ",", "bilateral", "ptosis", "and", "intermittent", "diverging", "strabismus", "on", "the", "right", "persisted", "for", "some", "weeks", ".", "It", "was", "6", "months", "before", "complete", "neurological", "resolution", "was", "achieved", ".", "The", "pathogenesis", "of", "salicylate", "toxicity", "and", "the", "need", "for", "safer", "therapies", "for", "ichthyosis", "vulgaris", "are", "discussed", "." ]	[ "umlsterm" ]
actin is a Individual_protein, profilin is a Individual_protein, actin is a Gene/protein/RNA	282_task0	Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]	Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.	[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
actin is a Individual_protein, profilin is a Individual_protein, actin is a Gene/protein/RNA	282_task1	Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please typing these entity words according to sentence: actin, profilin, actin Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]	Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.	[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
actin, profilin, actin	282_task2	Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]	Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.	[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
vitamin D receptor is a GENE-Y	23065592_task0	Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.	[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]	[ "GENE-Y", "CHEMICAL" ]
vitamin D receptor is a GENE-Y	23065592_task1	Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please typing these entity words according to sentence: vitamin D receptor Options: GENE-Y	[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.	[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]	[ "GENE-Y", "CHEMICAL" ]
vitamin D receptor	23065592_task2	Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.	[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]	[ "GENE-Y", "CHEMICAL" ]
AT1 is a GENE-Y, olmesartan medoxomil is a CHEMICAL	16775509_task0	Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]	Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.	[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
AT1 is a GENE-Y, olmesartan medoxomil is a CHEMICAL	16775509_task1	Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please typing these entity words according to sentence: AT1, olmesartan medoxomil Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]	Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.	[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
AT1, olmesartan medoxomil	16775509_task2	Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]	Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.	[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Tobacco is a Plant, mental illnesses is a Disease, substance abuse disorders is a Disease, tobacco is a Plant, chronic mental illness is a Disease, tobacco is a Plant	20001818_task0	Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant	[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.	[ "Tobacco", "use", "exerts", "a", "huge", "toll", "on", "persons", "with", "mental", "illnesses", "and", "substance", "abuse", "disorders", ",", "accounting", "for", "200,000", "of", "the", "annual", "443,000", "annual", "tobacco", "-", "related", "deaths", "in", "the", "United", "States", ".", "Persons", "with", "chronic", "mental", "illness", "die", "25", "years", "earlier", "than", "the", "general", "population", "does", ",", "and", "smoking", "is", "the", "major", "contributor", "to", "that", "premature", "mortality", ".", "This", "population", "consumes", "44", "%", "of", "all", "cigarettes", ",", "reflecting", "very", "high", "prevalence", "rates", "plus", "heavy", "smoking", "by", "users", ".", "The", "pattern", "reflects", "a", "combination", "of", "biological", ",", "psychosocial", ",", "cultural", ",", "and", "tobacco", "industry", "-", "related", "factors", ".", "Although", "provider", "and", "patient", "perspectives", "are", "changing", ",", "smoking", "has", "been", "a", "historically", "accepted", "part", "of", "behavioral", "health", "settings", ".", "Additional", "harm", "results", "from", "the", "economic", "burden", "imposed", "by", "purchasing", "cigarettes", "and", "enduring", "the", "stigma", "attached", "to", "smoking", ".", "Tailored", "treatment", "for", "this", "population", "involves", "standard", "cessation", "treatments", "including", "counseling", ",", "medications", ",", "and", "telephone", "quitlines", ".", "Further", "progress", "depends", "on", "clinician", "and", "patient", "education", ",", "expanded", "access", "to", "treatment", ",", "and", "the", "resolution", "of", "existing", "knowledge", "gaps", "." ]	[ "Disease", "Plant" ]
Tobacco is a Plant, mental illnesses is a Disease, substance abuse disorders is a Disease, tobacco is a Plant, chronic mental illness is a Disease, tobacco is a Plant	20001818_task1	Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please typing these entity words according to sentence: Tobacco, mental illnesses, substance abuse disorders, tobacco, chronic mental illness, tobacco Options: Disease, Plant	[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.	[ "Tobacco", "use", "exerts", "a", "huge", "toll", "on", "persons", "with", "mental", "illnesses", "and", "substance", "abuse", "disorders", ",", "accounting", "for", "200,000", "of", "the", "annual", "443,000", "annual", "tobacco", "-", "related", "deaths", "in", "the", "United", "States", ".", "Persons", "with", "chronic", "mental", "illness", "die", "25", "years", "earlier", "than", "the", "general", "population", "does", ",", "and", "smoking", "is", "the", "major", "contributor", "to", "that", "premature", "mortality", ".", "This", "population", "consumes", "44", "%", "of", "all", "cigarettes", ",", "reflecting", "very", "high", "prevalence", "rates", "plus", "heavy", "smoking", "by", "users", ".", "The", "pattern", "reflects", "a", "combination", "of", "biological", ",", "psychosocial", ",", "cultural", ",", "and", "tobacco", "industry", "-", "related", "factors", ".", "Although", "provider", "and", "patient", "perspectives", "are", "changing", ",", "smoking", "has", "been", "a", "historically", "accepted", "part", "of", "behavioral", "health", "settings", ".", "Additional", "harm", "results", "from", "the", "economic", "burden", "imposed", "by", "purchasing", "cigarettes", "and", "enduring", "the", "stigma", "attached", "to", "smoking", ".", "Tailored", "treatment", "for", "this", "population", "involves", "standard", "cessation", "treatments", "including", "counseling", ",", "medications", ",", "and", "telephone", "quitlines", ".", "Further", "progress", "depends", "on", "clinician", "and", "patient", "education", ",", "expanded", "access", "to", "treatment", ",", "and", "the", "resolution", "of", "existing", "knowledge", "gaps", "." ]	[ "Disease", "Plant" ]
Tobacco, mental illnesses, substance abuse disorders, tobacco, chronic mental illness, tobacco	20001818_task2	Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please extract entity words from the input sentence	[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.	[ "Tobacco", "use", "exerts", "a", "huge", "toll", "on", "persons", "with", "mental", "illnesses", "and", "substance", "abuse", "disorders", ",", "accounting", "for", "200,000", "of", "the", "annual", "443,000", "annual", "tobacco", "-", "related", "deaths", "in", "the", "United", "States", ".", "Persons", "with", "chronic", "mental", "illness", "die", "25", "years", "earlier", "than", "the", "general", "population", "does", ",", "and", "smoking", "is", "the", "major", "contributor", "to", "that", "premature", "mortality", ".", "This", "population", "consumes", "44", "%", "of", "all", "cigarettes", ",", "reflecting", "very", "high", "prevalence", "rates", "plus", "heavy", "smoking", "by", "users", ".", "The", "pattern", "reflects", "a", "combination", "of", "biological", ",", "psychosocial", ",", "cultural", ",", "and", "tobacco", "industry", "-", "related", "factors", ".", "Although", "provider", "and", "patient", "perspectives", "are", "changing", ",", "smoking", "has", "been", "a", "historically", "accepted", "part", "of", "behavioral", "health", "settings", ".", "Additional", "harm", "results", "from", "the", "economic", "burden", "imposed", "by", "purchasing", "cigarettes", "and", "enduring", "the", "stigma", "attached", "to", "smoking", ".", "Tailored", "treatment", "for", "this", "population", "involves", "standard", "cessation", "treatments", "including", "counseling", ",", "medications", ",", "and", "telephone", "quitlines", ".", "Further", "progress", "depends", "on", "clinician", "and", "patient", "education", ",", "expanded", "access", "to", "treatment", ",", "and", "the", "resolution", "of", "existing", "knowledge", "gaps", "." ]	[ "Disease", "Plant" ]
cadaver is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joint is an umlsterm, joint is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joints is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, needles is an umlsterm, anatomical is an umlsterm, all is an umlsterm, ligaments is an umlsterm, posterior is an umlsterm, ligament is an umlsterm, ligament is an umlsterm, radial nerve is an umlsterm, radial artery is an umlsterm, injury is an umlsterm, vein is an umlsterm, orientation is an umlsterm, joint is an umlsterm, nerves is an umlsterm, vessels is an umlsterm, cartilage is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, cartilage is an umlsterm, joint is an umlsterm	Arthroskopie.80110276.eng.abstr_task0	Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .	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cadaver is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joint is an umlsterm, joint is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joints is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, needles is an umlsterm, anatomical is an umlsterm, all is an umlsterm, ligaments is an umlsterm, posterior is an umlsterm, ligament is an umlsterm, ligament is an umlsterm, radial nerve is an umlsterm, radial artery is an umlsterm, injury is an umlsterm, vein is an umlsterm, orientation is an umlsterm, joint is an umlsterm, nerves is an umlsterm, vessels is an umlsterm, cartilage is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, cartilage is an umlsterm, joint is an umlsterm	Arthroskopie.80110276.eng.abstr_task1	Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please typing these entity words according to sentence: cadaver, human, hands, arthroscopy, joint, joint, human, hands, arthroscopy, joints, cartilage, metacarpal, needles, anatomical, all, ligaments, posterior, ligament, ligament, radial nerve, radial artery, injury, vein, orientation, joint, nerves, vessels, cartilage, cartilage, metacarpal, cartilage, joint Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .	[ "In", "a", "cadaver", "study", "on", "10", "human", "formalin", "-", "fixed", "hands", "we", "identified", "3", "different", "portals", "(", "palmar", ",", "radial", "and", "dorsal", ")", "for", "arthroscopy", "of", "the", "trapeziometacarpal", "joint", "and", "1", "portal", "(", "palmar", ")", "for", "the", "scaphotrapezial", "joint", ".", "In", "8", "cryoconserved", "human", "hands", "we", "performed", "standardized", "arthroscopy", "of", "these", "joints", "using", "the", "portals", "described", "above", "and", "arthroscopic", "resection", "of", "the", "cartilage", "of", "the", "trapezium", "and", "the", "first", "metacarpal", ".", "After", "marking", "the", "portals", "with", "needles", ",", "we", "made", "anatomical", "preparations", "of", "all", "the", "important", "structures", "of", "this", "region", ".", "We", "found", "slight", "lesions", "of", "the", "ligaments", "in", "2", "cases", "(", "oblique", "posterior", "ligament", "and", "trapeziometacarpal", "ligament", ")", ".", "We", "did", "not", "see", "any", "lesion", "of", "the", "radial", "nerve", "or", "the", "radial", "artery", ",", "but", "in", "one", "case", "an", "injury", "of", "a", "branch", "of", "the", "cephalic", "vein", ".", "To", "get", "the", "full", "orientation", "in", "the", "trapeziometacarpal", "joint", ",", "it", "is", "sufficient", "to", "use", "two", "of", "these", "portals", ".", "To", "prevent", "any", "lesion", "of", "nerves", "and", "vessels", ",", "we", "recommend", "the", "palmar", "and", "the", "radial", "portal", ".", "The", "preparation", "showed", "that", "65", "-", "85", "%", "of", "the", "cartilage", "of", "the", "trapezium", "was", "removed", "and", "60", "-", "75", "%", "of", "the", "cartilage", "in", "the", "first", "metacarpal", ".", "Hence", ",", "we", "were", "able", "to", "prove", "experimentally", "that", "arthroscopically", "assisted", "removal", "of", "the", "cartilage", "of", "the", "trapeziometacarpal", "joint", "is", "possible", "." ]	[ "umlsterm" ]
cadaver, human, hands, arthroscopy, joint, joint, human, hands, arthroscopy, joints, cartilage, metacarpal, needles, anatomical, all, ligaments, posterior, ligament, ligament, radial nerve, radial artery, injury, vein, orientation, joint, nerves, vessels, cartilage, cartilage, metacarpal, cartilage, joint	Arthroskopie.80110276.eng.abstr_task2	Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .	[ "In", "a", "cadaver", "study", "on", "10", "human", "formalin", "-", "fixed", "hands", "we", "identified", "3", "different", "portals", "(", "palmar", ",", "radial", "and", "dorsal", ")", "for", "arthroscopy", "of", "the", "trapeziometacarpal", "joint", "and", "1", "portal", "(", "palmar", ")", "for", "the", "scaphotrapezial", "joint", ".", "In", "8", "cryoconserved", "human", "hands", "we", "performed", "standardized", "arthroscopy", "of", "these", "joints", "using", "the", "portals", "described", "above", "and", "arthroscopic", "resection", "of", "the", "cartilage", "of", "the", "trapezium", "and", "the", "first", "metacarpal", ".", "After", "marking", "the", "portals", "with", "needles", ",", "we", "made", "anatomical", "preparations", "of", "all", "the", "important", "structures", "of", "this", "region", ".", "We", "found", "slight", "lesions", "of", "the", "ligaments", "in", "2", "cases", "(", "oblique", "posterior", "ligament", "and", "trapeziometacarpal", "ligament", ")", ".", "We", "did", "not", "see", "any", "lesion", "of", "the", "radial", "nerve", "or", "the", "radial", "artery", ",", "but", "in", "one", "case", "an", "injury", "of", "a", "branch", "of", "the", "cephalic", "vein", ".", "To", "get", "the", "full", "orientation", "in", "the", "trapeziometacarpal", "joint", ",", "it", "is", "sufficient", "to", "use", "two", "of", "these", "portals", ".", "To", "prevent", "any", "lesion", "of", "nerves", "and", "vessels", ",", "we", "recommend", "the", "palmar", "and", "the", "radial", "portal", ".", "The", "preparation", "showed", "that", "65", "-", "85", "%", "of", "the", "cartilage", "of", "the", "trapezium", "was", "removed", "and", "60", "-", "75", "%", "of", "the", "cartilage", "in", "the", "first", "metacarpal", ".", "Hence", ",", "we", "were", "able", "to", "prove", "experimentally", "that", "arthroscopically", "assisted", "removal", "of", "the", "cartilage", "of", "the", "trapeziometacarpal", "joint", "is", "possible", "." ]	[ "umlsterm" ]
between 3 to 16 years is a Value, age is a Person, undergoing is a Temporal, adenotonsillectomy is a Procedure, myringotomy is a Procedure, myringoplasty is a Procedure, ASA is a Measurement, 1 & 2 is a Value	NCT02162433_inc_task0	Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Value, Person, Procedure, Measurement	[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2	[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]	[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]
between 3 to 16 years is a Value, age is a Person, undergoing is a Temporal, adenotonsillectomy is a Procedure, myringotomy is a Procedure, myringoplasty is a Procedure, ASA is a Measurement, 1 & 2 is a Value	NCT02162433_inc_task1	Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please typing these entity words according to sentence: between 3 to 16 years, age, undergoing, adenotonsillectomy, myringotomy, myringoplasty, ASA, 1 & 2 Options: Temporal, Value, Person, Procedure, Measurement	[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2	[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]	[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]
between 3 to 16 years, age, undergoing, adenotonsillectomy, myringotomy, myringoplasty, ASA, 1 & 2	NCT02162433_inc_task2	Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please extract entity words from the input sentence	[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]	Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2	[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]	[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]
phospholipases A2 is a protein, oxygen is a compound	DS.d1518_task0	Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]	These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.	[ "These", "Ca2", "+", "-independent", "phospholipases", "A2", "display", "remarkable", "specificity", "for", "the", "length", "of", "the", "sn-2", "residue", ",", "but", "this", "selectivity", "is", "lost", "as", "the", "residue", "gains", "oxygen", "functions", "." ]	[ "protein", "compound" ]
phospholipases A2 is a protein, oxygen is a compound	DS.d1518_task1	Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please typing these entity words according to sentence: phospholipases A2, oxygen Options: compound, protein	[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]	These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.	[ "These", "Ca2", "+", "-independent", "phospholipases", "A2", "display", "remarkable", "specificity", "for", "the", "length", "of", "the", "sn-2", "residue", ",", "but", "this", "selectivity", "is", "lost", "as", "the", "residue", "gains", "oxygen", "functions", "." ]	[ "protein", "compound" ]
phospholipases A2, oxygen	DS.d1518_task2	Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]	These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.	[ "These", "Ca2", "+", "-independent", "phospholipases", "A2", "display", "remarkable", "specificity", "for", "the", "length", "of", "the", "sn-2", "residue", ",", "but", "this", "selectivity", "is", "lost", "as", "the", "residue", "gains", "oxygen", "functions", "." ]	[ "protein", "compound" ]
Glutathione S - transferase is a Gene/protein/RNA, Tax is a Gene/protein/RNA, Tax is a Individual_protein, CBP is a Individual_protein, p300 is a Individual_protein, CREB is a Individual_protein, Tax is a Individual_protein	302_task0	Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein	[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]	Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.	[ "Glutathione", "S", "-", "transferase", "pull", "-", "down", "performed", "with", "Tax", "deletion", "mutants", "and", "peptide", "competition", "have", "localized", "the", "site", "in", "Tax", "critical", "for", "binding", "CBP", "/", "p300", "to", "a", "highly", "protease", "-", "sensitive", "region", "around", "amino", "acid", "residues", "81", "to", "95", "(", "81QRTSKTLKVLTPPIT95", ")", "which", "lies", "between", "the", "domains", "previously", "proposed", "to", "be", "important", "for", "CREB", "binding", "and", "Tax", "subunit", "dimerization", "." ]	[ "Gene/protein/RNA", "Individual_protein" ]
Glutathione S - transferase is a Gene/protein/RNA, Tax is a Gene/protein/RNA, Tax is a Individual_protein, CBP is a Individual_protein, p300 is a Individual_protein, CREB is a Individual_protein, Tax is a Individual_protein	302_task1	Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please typing these entity words according to sentence: Glutathione S - transferase, Tax, Tax, CBP, p300, CREB, Tax Options: Gene/protein/RNA, Individual_protein	[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]	Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.	[ "Glutathione", "S", "-", "transferase", "pull", "-", "down", "performed", "with", "Tax", "deletion", "mutants", "and", "peptide", "competition", "have", "localized", "the", "site", "in", "Tax", "critical", "for", "binding", "CBP", "/", "p300", "to", "a", "highly", "protease", "-", "sensitive", "region", "around", "amino", "acid", "residues", "81", "to", "95", "(", "81QRTSKTLKVLTPPIT95", ")", "which", "lies", "between", "the", "domains", "previously", "proposed", "to", "be", "important", "for", "CREB", "binding", "and", "Tax", "subunit", "dimerization", "." ]	[ "Gene/protein/RNA", "Individual_protein" ]
Glutathione S - transferase, Tax, Tax, CBP, p300, CREB, Tax	302_task2	Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please extract entity words from the input sentence	[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]	Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.	[ "Glutathione", "S", "-", "transferase", "pull", "-", "down", "performed", "with", "Tax", "deletion", "mutants", "and", "peptide", "competition", "have", "localized", "the", "site", "in", "Tax", "critical", "for", "binding", "CBP", "/", "p300", "to", "a", "highly", "protease", "-", "sensitive", "region", "around", "amino", "acid", "residues", "81", "to", "95", "(", "81QRTSKTLKVLTPPIT95", ")", "which", "lies", "between", "the", "domains", "previously", "proposed", "to", "be", "important", "for", "CREB", "binding", "and", "Tax", "subunit", "dimerization", "." ]	[ "Gene/protein/RNA", "Individual_protein" ]
Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for is a Intervention_Pharmacological, malignant lymphoma is a Participant_Condition, . is a Outcome_Other, chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) is a Intervention_Pharmacological, chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ) is a Intervention_Pharmacological, 715 is a Participant_Sample-size, ML is a Participant_Condition, 281 is a Participant_Sample-size, complete remission ( CR ) is a Outcome_Physical, CR rate , CR duration , or survival is a Outcome_Physical, 388 is a Participant_Sample-size, Levamisole is a Intervention_Pharmacological, CR rates is a Outcome_Mortality, Chemoimmunotherapy with levamisole or levamisole - BCG is a Intervention_Pharmacological, CHOP chemotherapy is a Intervention_Physical	77204_task0	Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .	[ "Chemotherapy", "with", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "and", "prednisone", "alone", "or", "with", "levamisole", "or", "with", "levamisole", "plus", "BCG", "for", "malignant", "lymphoma", ":", "a", "Southwest", "Oncology", "Group", "Study", ".", "Between", "1977", "and", "1983", "the", "Southwest", "Oncology", "Group", "(", "SWOG", ")", "evaluated", "chemotherapy", "alone", "(", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "prednisone", ";", "CHOP", ")", "or", "chemoimmunotherapy", "(", "CHOP", "-", "levamisole", "or", "CHOP", "-", "levamisole", "-", "BCG", ")", "in", "a", "randomized", "prospective", "clinical", "trial", "involving", "715", "eligible", "patients", "with", "all", "types", "of", "malignant", "lymphoma", "(", "ML", ")", ".", "Of", "281", "evaluable", "patients", "with", "favorable", "histologic", "types", "of", "ML", ",", "171", "(", "61", "%", ")", "achieved", "complete", "remission", "(", "CR", ")", "and", "there", "was", "no", "difference", "in", "CR", "rate", ",", "CR", "duration", ",", "or", "survival", "according", "to", "the", "type", "of", "initial", "treatment", ".", "Of", "388", "evaluable", "patients", "with", "unfavorable", "histologic", "types", "of", "ML", ",", "194", "(", "50", "%", ")", "achieved", "CR", ".", "Levamisole", "appeared", "to", "adversely", "affect", "CR", "rates", "in", "nodular", "mixed", "and", "nodular", "large", "-", "cell", "lymphoma", "and", "CR", "duration", "in", "patients", "with", "unfavorable", "histology", "ML", ".", "Chemoimmunotherapy", "with", "levamisole", "or", "levamisole", "-", "BCG", "offers", "no", "advantage", "in", "terms", "of", "CR", "rates", ",", "CR", "duration", ",", "or", "survival", "compared", "to", "CHOP", "chemotherapy", "alone", ",", "and", "levamisole", "may", "have", "had", "an", "adverse", "impact", "on", "outcome", "in", "certain", "subtypes", "of", "ML", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]
Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for is a Intervention_Pharmacological, malignant lymphoma is a Participant_Condition, . is a Outcome_Other, chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) is a Intervention_Pharmacological, chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ) is a Intervention_Pharmacological, 715 is a Participant_Sample-size, ML is a Participant_Condition, 281 is a Participant_Sample-size, complete remission ( CR ) is a Outcome_Physical, CR rate , CR duration , or survival is a Outcome_Physical, 388 is a Participant_Sample-size, Levamisole is a Intervention_Pharmacological, CR rates is a Outcome_Mortality, Chemoimmunotherapy with levamisole or levamisole - BCG is a Intervention_Pharmacological, CHOP chemotherapy is a Intervention_Physical	77204_task1	Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please typing these entity words according to sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for, malignant lymphoma, ., chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ), chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ), 715, ML, 281, complete remission ( CR ), CR rate , CR duration , or survival, 388, Levamisole, CR rates, Chemoimmunotherapy with levamisole or levamisole - BCG, CHOP chemotherapy Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .	[ "Chemotherapy", "with", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "and", "prednisone", "alone", "or", "with", "levamisole", "or", "with", "levamisole", "plus", "BCG", "for", "malignant", "lymphoma", ":", "a", "Southwest", "Oncology", "Group", "Study", ".", "Between", "1977", "and", "1983", "the", "Southwest", "Oncology", "Group", "(", "SWOG", ")", "evaluated", "chemotherapy", "alone", "(", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "prednisone", ";", "CHOP", ")", "or", "chemoimmunotherapy", "(", "CHOP", "-", "levamisole", "or", "CHOP", "-", "levamisole", "-", "BCG", ")", "in", "a", "randomized", "prospective", "clinical", "trial", "involving", "715", "eligible", "patients", "with", "all", "types", "of", "malignant", "lymphoma", "(", "ML", ")", ".", "Of", "281", "evaluable", "patients", "with", "favorable", "histologic", "types", "of", "ML", ",", "171", "(", "61", "%", ")", "achieved", "complete", "remission", "(", "CR", ")", "and", "there", "was", "no", "difference", "in", "CR", "rate", ",", "CR", "duration", ",", "or", "survival", "according", "to", "the", "type", "of", "initial", "treatment", ".", "Of", "388", "evaluable", "patients", "with", "unfavorable", "histologic", "types", "of", "ML", ",", "194", "(", "50", "%", ")", "achieved", "CR", ".", "Levamisole", "appeared", "to", "adversely", "affect", "CR", "rates", "in", "nodular", "mixed", "and", "nodular", "large", "-", "cell", "lymphoma", "and", "CR", "duration", "in", "patients", "with", "unfavorable", "histology", "ML", ".", "Chemoimmunotherapy", "with", "levamisole", "or", "levamisole", "-", "BCG", "offers", "no", "advantage", "in", "terms", "of", "CR", "rates", ",", "CR", "duration", ",", "or", "survival", "compared", "to", "CHOP", "chemotherapy", "alone", ",", "and", "levamisole", "may", "have", "had", "an", "adverse", "impact", "on", "outcome", "in", "certain", "subtypes", "of", "ML", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]
Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for, malignant lymphoma, ., chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ), chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ), 715, ML, 281, complete remission ( CR ), CR rate , CR duration , or survival, 388, Levamisole, CR rates, Chemoimmunotherapy with levamisole or levamisole - BCG, CHOP chemotherapy	77204_task2	Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .	[ "Chemotherapy", "with", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "and", "prednisone", "alone", "or", "with", "levamisole", "or", "with", "levamisole", "plus", "BCG", "for", "malignant", "lymphoma", ":", "a", "Southwest", "Oncology", "Group", "Study", ".", "Between", "1977", "and", "1983", "the", "Southwest", "Oncology", "Group", "(", "SWOG", ")", "evaluated", "chemotherapy", "alone", "(", "cyclophosphamide", ",", "doxorubicin", ",", "vincristine", ",", "prednisone", ";", "CHOP", ")", "or", "chemoimmunotherapy", "(", "CHOP", "-", "levamisole", "or", "CHOP", "-", "levamisole", "-", "BCG", ")", "in", "a", "randomized", "prospective", "clinical", "trial", "involving", "715", "eligible", "patients", "with", "all", "types", "of", "malignant", "lymphoma", "(", "ML", ")", ".", "Of", "281", "evaluable", "patients", "with", "favorable", "histologic", "types", "of", "ML", ",", "171", "(", "61", "%", ")", "achieved", "complete", "remission", "(", "CR", ")", "and", "there", "was", "no", "difference", "in", "CR", "rate", ",", "CR", "duration", ",", "or", "survival", "according", "to", "the", "type", "of", "initial", "treatment", ".", "Of", "388", "evaluable", "patients", "with", "unfavorable", "histologic", "types", "of", "ML", ",", "194", "(", "50", "%", ")", "achieved", "CR", ".", "Levamisole", "appeared", "to", "adversely", "affect", "CR", "rates", "in", "nodular", "mixed", "and", "nodular", "large", "-", "cell", "lymphoma", "and", "CR", "duration", "in", "patients", "with", "unfavorable", "histology", "ML", ".", "Chemoimmunotherapy", "with", "levamisole", "or", "levamisole", "-", "BCG", "offers", "no", "advantage", "in", "terms", "of", "CR", "rates", ",", "CR", "duration", ",", "or", "survival", "compared", "to", "CHOP", "chemotherapy", "alone", ",", "and", "levamisole", "may", "have", "had", "an", "adverse", "impact", "on", "outcome", "in", "certain", "subtypes", "of", "ML", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]
stearic acid is a compound, MCP-1 is a protein	DS.d517_task0	Sentence: The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O" ]	The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4.	[ "The", "stimulatory", "effects", "of", "stearic", ",", "palmitic", "and", "palmitoleic", "acids", "on", "resistin", "secretion", "and", "the", "stimulatory", "effect", "of", "stearic", "acid", "on", "MCP-1", "secretion", "are", "mediated", "via", "TLR-4", "." ]	[ "compound", "protein" ]

Rac is a protein-family, GTP is a chemical, Rac is a protein-family

1.0alpha7.train.905_task0

Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: chemical, protein-family

[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]

Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.

[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]

[ "chemical", "protein-family" ]

Rac is a protein-family, GTP is a chemical, Rac is a protein-family

1.0alpha7.train.905_task1

Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please typing these entity words according to sentence: Rac, GTP, Rac Options: chemical, protein-family

[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]

Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.

[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]

[ "chemical", "protein-family" ]

Rac, GTP, Rac

1.0alpha7.train.905_task2

Sentence: Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting. Instructions: please extract entity words from the input sentence

[ "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-chemical", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O" ]

Rac was immunoprecipitated, and following extensive washing the amount of GTP bound to Rac was estimated by scintillation counting.

[ "Rac", "was", "immunoprecipitated", ",", "and", "following", "extensive", "washing", "the", "amount", "of", "GTP", "bound", "to", "Rac", "was", "estimated", "by", "scintillation", "counting", "." ]

[ "chemical", "protein-family" ]

Rueckenmarks is an umlsterm, Anaesthesie is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Komplikationen is an umlsterm

DerAnaesthesist.50440483.ger.abstr_task0

Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .

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[ "umlsterm" ]

Rueckenmarks is an umlsterm, Anaesthesie is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Komplikationen is an umlsterm

DerAnaesthesist.50440483.ger.abstr_task1

Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please typing these entity words according to sentence: Rueckenmarks, Anaesthesie, Patienten, Bupivacain, Komplikationen Options: umlsterm

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Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .

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[ "umlsterm" ]

Rueckenmarks, Anaesthesie, Patienten, Bupivacain, Komplikationen

DerAnaesthesist.50440483.ger.abstr_task2

Sentence: Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen . Instructions: please extract entity words from the input sentence

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Der Morbus Friedreich stellt eine sehr seltene neurologische Erkrankung dar , bei der es bereits beim jungen Erwachsenen zu Degenerationen im Bereich der Hinterwurzel und schliesslich im Bereich der Vorderwurzel des Rueckenmarks kommt . Besonders im Rahmen des Bereitschaftsdienstes steht man ploetzlich vor der Frage , ob im Rahmen einer Anaesthesie eines solchen Patienten eher der Intubationsnarkose , oder aber einem regionalen Betaeubungsverfahren der Vorzug gegeben werden sollte . Wir berichten ueber eine 36jaehrige Patientin mit einer spinocerebellaeren heredoataxie ( Morbus Friedreich ) , die sich einem proktologischen Eingriff unterziehen musste . Hierbei erfolgte eine Spinalanaesthesie mittels 3 mg hyperbarem Bupivacain im Sitzen . Sowohl der intra- als auch der postoperative Verlauf waren unauffaellig , insbesondere in bezug auf die neurologische Grunderkrankung kam es zu keinerlei Komplikationen .

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[ "umlsterm" ]

Gro - interaction domain is a protein-domain, Lz is a protein, VWRPY is a protein-motif, VWEAA is a protein-motif, Gro is a protein, bHLH proteins is a protein-family

1.0alpha7.train.742_task0

Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-motif, protein-domain, protein, protein-family

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We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).

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[ "protein-domain", "protein-family", "protein-motif", "protein" ]

Gro - interaction domain is a protein-domain, Lz is a protein, VWRPY is a protein-motif, VWEAA is a protein-motif, Gro is a protein, bHLH proteins is a protein-family

1.0alpha7.train.742_task1

Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please typing these entity words according to sentence: Gro - interaction domain, Lz, VWRPY, VWEAA, Gro, bHLH proteins Options: protein-motif, protein-domain, protein, protein-family

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We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).

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[ "protein-domain", "protein-family", "protein-motif", "protein" ]

Gro - interaction domain, Lz, VWRPY, VWEAA, Gro, bHLH proteins

1.0alpha7.train.742_task2

Sentence: We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ). Instructions: please extract entity words from the input sentence

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We therefore altered the Gro-interaction domain at the C terminus of Lz from VWRPY to VWEAA, a change that abrogates Gro binding to bHLH proteins (Goldstein et al. 1999 ).

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[ "protein-domain", "protein-family", "protein-motif", "protein" ]

knowledge is an umlsterm, nerve regeneration is an umlsterm, repair is an umlsterm, nerve is an umlsterm, traumatic injury is an umlsterm, central nervous system is an umlsterm, CNS is an umlsterm, regeneration is an umlsterm, functional recovery is an umlsterm, spinal cord injury is an umlsterm, animal models is an umlsterm, growth - inhibitory is an umlsterm, CNS is an umlsterm, neurons is an umlsterm, therapies is an umlsterm, treatment is an umlsterm, spinal cord is an umlsterm, patients is an umlsterm, neurobiology is an umlsterm, spinal cord trauma is an umlsterm, findings is an umlsterm, light is an umlsterm

DerNervenarzt.90700702.eng.abstr_task0

Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .

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[ "umlsterm" ]

knowledge is an umlsterm, nerve regeneration is an umlsterm, repair is an umlsterm, nerve is an umlsterm, traumatic injury is an umlsterm, central nervous system is an umlsterm, CNS is an umlsterm, regeneration is an umlsterm, functional recovery is an umlsterm, spinal cord injury is an umlsterm, animal models is an umlsterm, growth - inhibitory is an umlsterm, CNS is an umlsterm, neurons is an umlsterm, therapies is an umlsterm, treatment is an umlsterm, spinal cord is an umlsterm, patients is an umlsterm, neurobiology is an umlsterm, spinal cord trauma is an umlsterm, findings is an umlsterm, light is an umlsterm

DerNervenarzt.90700702.eng.abstr_task1

Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please typing these entity words according to sentence: knowledge, nerve regeneration, repair, nerve, traumatic injury, central nervous system, CNS, regeneration, functional recovery, spinal cord injury, animal models, growth - inhibitory, CNS, neurons, therapies, treatment, spinal cord, patients, neurobiology, spinal cord trauma, findings, light Options: umlsterm

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In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .

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[ "umlsterm" ]

knowledge, nerve regeneration, repair, nerve, traumatic injury, central nervous system, CNS, regeneration, functional recovery, spinal cord injury, animal models, growth - inhibitory, CNS, neurons, therapies, treatment, spinal cord, patients, neurobiology, spinal cord trauma, findings, light

DerNervenarzt.90700702.eng.abstr_task2

Sentence: In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations . Instructions: please extract entity words from the input sentence

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In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations .

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[ "umlsterm" ]

NF - kappaB is a Complex, RelA is a Gene_or_gene_product, protein kinase Czeta is a Gene_or_gene_product, NF - kappaB is a Complex, cytoplasmic is a Cellular_component, IkappaB is a Gene_or_gene_product, NF - kappaB is a Complex, RelA is a Gene_or_gene_product, NF - kappaB is a Complex, protein kinase Czeta is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Rel is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Raf is a Gene_or_gene_product, MEK is a Gene_or_gene_product, phosphatidylinositol 3-kinase is a Gene_or_gene_product, stress - activated protein kinase is a Gene_or_gene_product

1_task0

Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Complex, Gene_or_gene_product, Cellular_component

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Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.

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[ "Gene_or_gene_product", "Cellular_component", "Complex" ]

NF - kappaB is a Complex, RelA is a Gene_or_gene_product, protein kinase Czeta is a Gene_or_gene_product, NF - kappaB is a Complex, cytoplasmic is a Cellular_component, IkappaB is a Gene_or_gene_product, NF - kappaB is a Complex, RelA is a Gene_or_gene_product, NF - kappaB is a Complex, protein kinase Czeta is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Rel is a Gene_or_gene_product, PKCzeta is a Gene_or_gene_product, RelA is a Gene_or_gene_product, Raf is a Gene_or_gene_product, MEK is a Gene_or_gene_product, phosphatidylinositol 3-kinase is a Gene_or_gene_product, stress - activated protein kinase is a Gene_or_gene_product

1_task1

Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please typing these entity words according to sentence: NF - kappaB, RelA, protein kinase Czeta, NF - kappaB, cytoplasmic, IkappaB, NF - kappaB, RelA, NF - kappaB, protein kinase Czeta, PKCzeta, RelA, Rel, PKCzeta, RelA, Raf, MEK, phosphatidylinositol 3-kinase, stress - activated protein kinase Options: Complex, Gene_or_gene_product, Cellular_component

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Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.

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[ "Gene_or_gene_product", "Cellular_component", "Complex" ]

NF - kappaB, RelA, protein kinase Czeta, NF - kappaB, cytoplasmic, IkappaB, NF - kappaB, RelA, NF - kappaB, protein kinase Czeta, PKCzeta, RelA, Rel, PKCzeta, RelA, Raf, MEK, phosphatidylinositol 3-kinase, stress - activated protein kinase

1_task2

Sentence: Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. Instructions: please extract entity words from the input sentence

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Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules. Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB. In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras). We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain. Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding. Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.

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[ "Gene_or_gene_product", "Cellular_component", "Complex" ]

Mechanical ventilation is an umlsterm, intensive care is an umlsterm, medicine is an umlsterm, ICU is an umlsterm, trauma is an umlsterm, patients is an umlsterm, analgesia is an umlsterm, benzodiazepines is an umlsterm, opioids is an umlsterm, time is an umlsterm, period is an umlsterm, withdrawal syndrome is an umlsterm, tachycardia is an umlsterm, hypertonia is an umlsterm, restlessness is an umlsterm, treatment is an umlsterm, clonidine is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, mechanical ventilation is an umlsterm, sufentanil is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, depression is an umlsterm, fentanyl is an umlsterm, frequency is an umlsterm, patient is an umlsterm, physician is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, period is an umlsterm, ventilation is an umlsterm, discharge is an umlsterm, ICU is an umlsterm

DerChirurg.90700066.eng.abstr_task0

Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .

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[ "umlsterm" ]

Mechanical ventilation is an umlsterm, intensive care is an umlsterm, medicine is an umlsterm, ICU is an umlsterm, trauma is an umlsterm, patients is an umlsterm, analgesia is an umlsterm, benzodiazepines is an umlsterm, opioids is an umlsterm, time is an umlsterm, period is an umlsterm, withdrawal syndrome is an umlsterm, tachycardia is an umlsterm, hypertonia is an umlsterm, restlessness is an umlsterm, treatment is an umlsterm, clonidine is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, mechanical ventilation is an umlsterm, sufentanil is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, depression is an umlsterm, fentanyl is an umlsterm, frequency is an umlsterm, patient is an umlsterm, physician is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, period is an umlsterm, ventilation is an umlsterm, discharge is an umlsterm, ICU is an umlsterm

DerChirurg.90700066.eng.abstr_task1

Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please typing these entity words according to sentence: Mechanical ventilation, intensive care, medicine, ICU, trauma, patients, analgesia, benzodiazepines, opioids, time, period, withdrawal syndrome, tachycardia, hypertonia, restlessness, treatment, clonidine, symptoms, patients, mechanical ventilation, sufentanil, opioid, analgesia, depression, fentanyl, frequency, patient, physician, patients, clonidine, patients, period, ventilation, discharge, ICU Options: umlsterm

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Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .

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[ "umlsterm" ]

Mechanical ventilation, intensive care, medicine, ICU, trauma, patients, analgesia, benzodiazepines, opioids, time, period, withdrawal syndrome, tachycardia, hypertonia, restlessness, treatment, clonidine, symptoms, patients, mechanical ventilation, sufentanil, opioid, analgesia, depression, fentanyl, frequency, patient, physician, patients, clonidine, patients, period, ventilation, discharge, ICU

DerChirurg.90700066.eng.abstr_task2

Sentence: Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % . Instructions: please extract entity words from the input sentence

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Mechanical ventilation is a well-etablished strategy in intensive care medicine . ICU trauma patients require analgesia , and sedation mostly consists of benzodiazepines and opioids with increasing doses over time . The weaning period is complicated by the withdrawal syndrome , showing tachycardia , hypertonia , tachypnea and restlessness . Although treatment with clonidine can influence these symptoms , tachypnea still remains the main problem in weaning patients from mechanical ventilation . Adding sufentanil , an opioid with greater effects on analgesia than on respiratory depression compared with fentanyl , tachypnea can be reduced to normal frequency . In this way weaning management can be managed more easily for the benefit of both , the patient and physician . In comparison with a group of 50 patients treated with clonidine alone , 72 patients treated with clonidine/sufentanil showed a shorter period from the start of spontaneous ventilation until extubation ( 4.8 vs 7.6 days ) and until discharge from the ICU ( 7.7 vs 12.4 days ) . The number of reintubations caused by respiratory exhaustion decreased from 16.0 to 2.8 % .

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[ "umlsterm" ]

Kryochirurgie is an umlsterm, Methode is an umlsterm, Behandlung is an umlsterm, Saeuglingshaemangiome is an umlsterm, Zeit is an umlsterm, unterliegenden is an umlsterm, Tumoren is an umlsterm

DerHautarzt.00510231.ger.abstr_task0

Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]

Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .

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[ "umlsterm" ]

Kryochirurgie is an umlsterm, Methode is an umlsterm, Behandlung is an umlsterm, Saeuglingshaemangiome is an umlsterm, Zeit is an umlsterm, unterliegenden is an umlsterm, Tumoren is an umlsterm

DerHautarzt.00510231.ger.abstr_task1

Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please typing these entity words according to sentence: Kryochirurgie, Methode, Behandlung, Saeuglingshaemangiome, Zeit, unterliegenden, Tumoren Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]

Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .

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[ "umlsterm" ]

Kryochirurgie, Methode, Behandlung, Saeuglingshaemangiome, Zeit, unterliegenden, Tumoren

DerHautarzt.00510231.ger.abstr_task2

Sentence: Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen . Instructions: please extract entity words from the input sentence

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Hintergrund und Fragestellung . Kryochirurgie ist als Methode zur Behandlung kapillaerer Saeuglingshaemangiome seit langer Zeit etabliert . Erstaunlicherweise fehlen aber bisher detaillierte Studien , die ihre Effektivitaet bei den regelmaessig der Spontanregression unterliegenden Tumoren belegen .

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[ "umlsterm" ]

( Na+ + K+)-ATPase beta - subunit is a Protein, Asn-157 is a Entity, Asn-192 is a Entity, Asn-264 is a Entity

318_task0

Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.

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[ "Protein", "Entity" ]

( Na+ + K+)-ATPase beta - subunit is a Protein, Asn-157 is a Entity, Asn-192 is a Entity, Asn-264 is a Entity

318_task1

Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please typing these entity words according to sentence: ( Na+ + K+)-ATPase beta - subunit, Asn-157, Asn-192, Asn-264 Options: Entity, Protein

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All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.

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[ "Protein", "Entity" ]

( Na+ + K+)-ATPase beta - subunit, Asn-157, Asn-192, Asn-264

318_task2

Sentence: All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174. Instructions: please extract entity words from the input sentence

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All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide. The beta-subunit of dog kidney (Na+ + K+)-ATPase is a sialoglycoprotein and contains three potential N-glycosylation sites. In this study, the oligosaccharide chains of purified dog kidney beta-subunit were labeled with tritium by oxidation with sodium periodate or galactose oxidase followed by NaB3H4 reduction. The beta-subunit was extensively digested by trypsin and the radioactive peptides were purified by HPLC. The enzyme, glycopeptidase A, which catalyzes the removal of N-linked oligosaccharide chains and the conversion of the glycosylated Asn residue to Asp, was used to demonstrate that a number of purified beta-subunit tryptic peptides were glycosylated. Amino-acid analysis of these beta-subunit peptides following glycopeptidase-A treatment revealed the expected Asn to Asp conversion for Asn-157, Asn-192 and Asn-264, demonstrating that all three potential N-glycosylation sites of the dog kidney beta-subunit are glycosylated. In addition, amino-acid sequence data suggest that a disulfide bond exists between Cys-158 and Cys-174.

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[ "Protein", "Entity" ]

silver is a CHEMICAL

23086748_task0

Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effects of silver nanoparticles on the liver and hepatocytes in vitro.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

silver is a CHEMICAL

23086748_task1

Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please typing these entity words according to sentence: silver Options: CHEMICAL

[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effects of silver nanoparticles on the liver and hepatocytes in vitro.

[ "Effects", "of", "silver", "nanoparticles", "on", "the", "liver", "and", "hepatocytes", "in", "vitro", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

silver

23086748_task2

Sentence: Effects of silver nanoparticles on the liver and hepatocytes in vitro. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effects of silver nanoparticles on the liver and hepatocytes in vitro.

[ "Effects", "of", "silver", "nanoparticles", "on", "the", "liver", "and", "hepatocytes", "in", "vitro", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

granulocyte - macrophage colony - stimulating factor is a Protein, E - selectin is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein, regulatory elements is a Entity, GM - CSF is a Protein, E - selectin is a Protein, vascular cell adhesion molecule-1 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, promoter is a Entity, NF - kappa B is a Entity, tumor necrosis factor ( TNF)-alpha is a Protein, chromatin is a Entity, DNasel is a Protein, hypersensitive sites is a Entity, GM - CSF is a Protein, enhancer is a Entity, E - selectin is a Protein, promoter is a Entity

422_task0

Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.

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[ "Protein", "Entity" ]

granulocyte - macrophage colony - stimulating factor is a Protein, E - selectin is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein, GM - CSF is a Protein, regulatory elements is a Entity, GM - CSF is a Protein, E - selectin is a Protein, vascular cell adhesion molecule-1 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, promoter is a Entity, NF - kappa B is a Entity, tumor necrosis factor ( TNF)-alpha is a Protein, chromatin is a Entity, DNasel is a Protein, hypersensitive sites is a Entity, GM - CSF is a Protein, enhancer is a Entity, E - selectin is a Protein, promoter is a Entity

422_task1

Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please typing these entity words according to sentence: granulocyte - macrophage colony - stimulating factor, E - selectin, granulocyte - macrophage colony - stimulating factor, GM - CSF, regulatory elements, GM - CSF, E - selectin, vascular cell adhesion molecule-1, VCAM-1, E - selectin, promoter, NF - kappa B, tumor necrosis factor ( TNF)-alpha, chromatin, DNasel, hypersensitive sites, GM - CSF, enhancer, E - selectin, promoter Options: Entity, Protein

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Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.

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[ "Protein", "Entity" ]

granulocyte - macrophage colony - stimulating factor, E - selectin, granulocyte - macrophage colony - stimulating factor, GM - CSF, regulatory elements, GM - CSF, E - selectin, vascular cell adhesion molecule-1, VCAM-1, E - selectin, promoter, NF - kappa B, tumor necrosis factor ( TNF)-alpha, chromatin, DNasel, hypersensitive sites, GM - CSF, enhancer, E - selectin, promoter

422_task2

Sentence: Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA). As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells. Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%. CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells. CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT. Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion. The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA. This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.

[ "Regulation", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "and", "E", "-", "selectin", "expression", "in", "endothelial", "cells", "by", "cyclosporin", "A", "and", "the", "T", "-", "cell", "transcription", "factor", "NFAT", ".", "\n", "Nuclear", "factor", "of", "activated", "T", "cells", "(", "NFAT", ")", "was", "originally", "described", "as", "a", "T", "-", "cell", "-", "specific", "transcription", "factor", "athat", "supported", "the", "activation", "of", "cytokine", "gene", "expression", "and", "mediated", "the", "immunoregulatory", "effects", "of", "cyclosporin", "A", "(", "CsA", ")", ".", "As", "we", "observed", "that", "activated", "endothelial", "cells", "also", "expressed", "NFAT", ",", "we", "tested", "the", "antiinflammatory", "properties", "of", "CsA", "in", "endothelial", "cells", ".", "Significantly", ",", "CsA", "completely", "suppressed", "the", "induction", "of", "NFAT", "in", "endothelial", "cells", "and", "inhibited", "the", "activity", "of", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "(", "GM", "-", "CSF", ")", "gene", "regulatory", "elements", "that", "use", "NFAT", "by", "60", "%", ".", "CsA", "similarly", "mediated", "a", "reduction", "of", "up", "to", "65", "%", "in", "GM", "-", "CSF", "mRNA", "and", "protein", "expression", "in", "activated", "endothelial", "cells", ".", "CsA", "also", "suppressed", "E", "-", "selectin", ",", "but", "not", "vascular", "cell", "adhesion", "molecule-1", "(", "VCAM-1", ")", "expression", "in", "endothelial", "cells", ",", "even", "though", "the", "E", "-", "selectin", "promoter", "is", "activated", "by", "NF", "-", "kappa", "B", "rather", "than", "NFAT", ".", "Hence", ",", "induction", "of", "cell", "surface", "expression", "of", "this", "leukocyte", "adhesion", "molecule", "by", "tumor", "necrosis", "factor", "(", "TNF)-alpha", "was", "reduced", "by", "40", "%", "in", "the", "presence", "of", "CsA", ",", "and", "this", "was", "reflected", "by", "a", "29", "%", "decrease", "in", "neutrophil", "adhesion", ".", "The", "effects", "of", "CsA", "on", "endothelial", "cells", "were", "also", "detected", "at", "the", "chromatin", "structure", "level", ",", "as", "DNasel", "hypersensitive", "sites", "within", "both", "the", "GM", "-", "CSF", "enhancer", "and", "the", "E", "-", "selectin", "promoter", "were", "suppressed", "by", "CsA.", "This", "represents", "the", "first", "report", "of", "NFAT", "in", "endothelial", "cells", "and", "suggests", "mechanisms", "by", "which", "CsA", "could", "function", "as", "an", "antiinflammatory", "agent", ".", "\n" ]

[ "Protein", "Entity" ]

BCK1 is a Gene, MEKK is a DNA_family_or_group, BCK1 - 20 is a Gene, MKK1 is a Gene, MEK is a DNA_family_or_group, MPK1 is a Gene, MAP kinase is a DNA_family_or_group, PKC1 is a Gene, glc7 - 10 is a Gene, Pkc1p is a Individual_protein, ROM2 is a Gene, RHO2 is a Gene, HCS77 is a Gene, WSC1 is a Gene, SLG1 is a Gene, MID2 is a Gene, glc7 - 10 is a Gene

68_task0

Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, Gene, Individual_protein

[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]

Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.

[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]

[ "DNA_family_or_group", "Gene", "Individual_protein" ]

BCK1 is a Gene, MEKK is a DNA_family_or_group, BCK1 - 20 is a Gene, MKK1 is a Gene, MEK is a DNA_family_or_group, MPK1 is a Gene, MAP kinase is a DNA_family_or_group, PKC1 is a Gene, glc7 - 10 is a Gene, Pkc1p is a Individual_protein, ROM2 is a Gene, RHO2 is a Gene, HCS77 is a Gene, WSC1 is a Gene, SLG1 is a Gene, MID2 is a Gene, glc7 - 10 is a Gene

68_task1

Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please typing these entity words according to sentence: BCK1, MEKK, BCK1 - 20, MKK1, MEK, MPK1, MAP kinase, PKC1, glc7 - 10, Pkc1p, ROM2, RHO2, HCS77, WSC1, SLG1, MID2, glc7 - 10 Options: DNA_family_or_group, Gene, Individual_protein

[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]

Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.

[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]

[ "DNA_family_or_group", "Gene", "Individual_protein" ]

BCK1, MEKK, BCK1 - 20, MKK1, MEK, MPK1, MAP kinase, PKC1, glc7 - 10, Pkc1p, ROM2, RHO2, HCS77, WSC1, SLG1, MID2, glc7 - 10

68_task2

Sentence: Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "O", "O", "B-Gene", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "B-Gene", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O" ]

Although neither activation of BCK1 (MEKK) by the dominant BCK1-20 mutation nor increased dosage of MKK1 (MEK) or MPK1 (MAP kinase) mimicked PKC1 as a glc7-10 dosage suppressor, extra copies of genes encoding upstream components of the Pkc1p pathway such as ROM2, RHO2, HCS77/WSC1/SLG1 and MID2 also suppressed glc7-10 effectively.

[ "Although", "neither", "activation", "of", "BCK1", "(", "MEKK", ")", "by", "the", "dominant", "BCK1", "-", "20", "mutation", "nor", "increased", "dosage", "of", "MKK1", "(", "MEK", ")", "or", "MPK1", "(", "MAP", "kinase", ")", "mimicked", "PKC1", "as", "a", "glc7", "-", "10", "dosage", "suppressor", ",", "extra", "copies", "of", "genes", "encoding", "upstream", "components", "of", "the", "Pkc1p", "pathway", "such", "as", "ROM2", ",", "RHO2", ",", "HCS77", "/", "WSC1", "/", "SLG1", "and", "MID2", "also", "suppressed", "glc7", "-", "10", "effectively", "." ]

[ "DNA_family_or_group", "Gene", "Individual_protein" ]

actin is a Individual_protein, alpha - catenin is a Individual_protein, beta - catenin is a Individual_protein, plakoglobin is a Individual_protein, zyxin is a Individual_protein

534_task0

Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.

[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]

[ "Individual_protein" ]

actin is a Individual_protein, alpha - catenin is a Individual_protein, beta - catenin is a Individual_protein, plakoglobin is a Individual_protein, zyxin is a Individual_protein

534_task1

Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please typing these entity words according to sentence: actin, alpha - catenin, beta - catenin, plakoglobin, zyxin Options: Individual_protein

[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.

[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]

[ "Individual_protein" ]

actin, alpha - catenin, beta - catenin, plakoglobin, zyxin

534_task2

Sentence: Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Molecules known to link actin filaments to membrane were also examined, including alpha-catenin, beta-catenin, plakoglobin, and zyxin, but none was identified at the host-parasite junction.

[ "Molecules", "known", "to", "link", "actin", "filaments", "to", "membrane", "were", "also", "examined", ",", "including", "alpha", "-", "catenin", ",", "beta", "-", "catenin", ",", "plakoglobin", ",", "and", "zyxin", ",", "but", "none", "was", "identified", "at", "the", "host", "-", "parasite", "junction", "." ]

[ "Individual_protein" ]

child is a Species

506_task0

Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Species

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]

They are transmitted through sex contact, parenterally and from mother to child.

[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]

[ "Diseases", "Relation_Trigger", "Species" ]

child is a Species

506_task1

Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please typing these entity words according to sentence: child Options: Species

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]

They are transmitted through sex contact, parenterally and from mother to child.

[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]

[ "Diseases", "Relation_Trigger", "Species" ]

child

506_task2

Sentence: They are transmitted through sex contact, parenterally and from mother to child. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Species", "O" ]

They are transmitted through sex contact, parenterally and from mother to child.

[ "They", "are", "transmitted", "through", "sex", "contact", ",", "parenterally", "and", "from", "mother", "to", "child", "." ]

[ "Diseases", "Relation_Trigger", "Species" ]

beta - globin is a Gene

449_task0

Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene

[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.

[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]

[ "Gene" ]

beta - globin is a Gene

449_task1

Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please typing these entity words according to sentence: beta - globin Options: Gene

[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.

[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]

[ "Gene" ]

beta - globin

449_task2

Sentence: Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Sequence of the -530 region of the beta-globin gene of sickle cell anemia patients with the Arabian haplotype.

[ "Sequence", "of", "the", "-530", "region", "of", "the", "beta", "-", "globin", "gene", "of", "sickle", "cell", "anemia", "patients", "with", "the", "Arabian", "haplotype", ".", "\n" ]

[ "Gene" ]

determination is an umlsterm, procalcitonin is an umlsterm, intensive care is an umlsterm, patients is an umlsterm, microbiological is an umlsterm, PCT is an umlsterm, ICU is an umlsterm, patients is an umlsterm, techniques is an umlsterm

IntensiveMedizin.80350124.eng.abstr_task0

Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .

[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]

[ "umlsterm" ]

determination is an umlsterm, procalcitonin is an umlsterm, intensive care is an umlsterm, patients is an umlsterm, microbiological is an umlsterm, PCT is an umlsterm, ICU is an umlsterm, patients is an umlsterm, techniques is an umlsterm

IntensiveMedizin.80350124.eng.abstr_task1

Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please typing these entity words according to sentence: determination, procalcitonin, intensive care, patients, microbiological, PCT, ICU, patients, techniques Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .

[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]

[ "umlsterm" ]

determination, procalcitonin, intensive care, patients, microbiological, PCT, ICU, patients, techniques

IntensiveMedizin.80350124.eng.abstr_task2

Sentence: In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

In order to evaluate , if the routine determination of procalcitonin in intensive care patients provides additional information to clinical , radiological and microbiological examinations , we determined serum PCT levels of 12 consecutive ICU patients for up to 35 days after admission . These results were compared to the above mentioned routine techniques .

[ "In", "order", "to", "evaluate", ",", "if", "the", "routine", "determination", "of", "procalcitonin", "in", "intensive", "care", "patients", "provides", "additional", "information", "to", "clinical", ",", "radiological", "and", "microbiological", "examinations", ",", "we", "determined", "serum", "PCT", "levels", "of", "12", "consecutive", "ICU", "patients", "for", "up", "to", "35", "days", "after", "admission", ".", "These", "results", "were", "compared", "to", "the", "above", "mentioned", "routine", "techniques", "." ]

[ "umlsterm" ]

mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1-PGC-1alpha is a Complex, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha is a Gene_or_gene_product, mitochondrial is a Cellular_component, mammalian target of rapamycin is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, rapamycin is a Simple_chemical, mitochondrial is a Cellular_component, PGC-1alpha is a Gene_or_gene_product, oestrogen - related receptor alpha is a Gene_or_gene_product, nuclear is a Cellular_component, mitochondrial is a Cellular_component, oxygen is a Simple_chemical, yin - yang 1 is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1 is a Gene_or_gene_product, rapamycin is a Simple_chemical, mTOR is a Gene_or_gene_product, raptor is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component

180_task0

Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component

[ "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.

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[ "Gene_or_gene_product", "Complex", "Cellular_component", "Simple_chemical" ]

mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1-PGC-1alpha is a Complex, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha is a Gene_or_gene_product, mitochondrial is a Cellular_component, mammalian target of rapamycin is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component, mTOR is a Gene_or_gene_product, rapamycin is a Simple_chemical, mitochondrial is a Cellular_component, PGC-1alpha is a Gene_or_gene_product, oestrogen - related receptor alpha is a Gene_or_gene_product, nuclear is a Cellular_component, mitochondrial is a Cellular_component, oxygen is a Simple_chemical, yin - yang 1 is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mitochondrial is a Cellular_component, YY1 is a Gene_or_gene_product, rapamycin is a Simple_chemical, mTOR is a Gene_or_gene_product, raptor is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, YY1 is a Gene_or_gene_product, PGC-1alpha is a Gene_or_gene_product, mTOR is a Gene_or_gene_product, mitochondrial is a Cellular_component

180_task1

Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. Instructions: please typing these entity words according to sentence: mTOR, mitochondrial, YY1-PGC-1alpha, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha, mitochondrial, mammalian target of rapamycin, mTOR, mTOR, mitochondrial, mTOR, mitochondrial, mTOR, rapamycin, mitochondrial, PGC-1alpha, oestrogen - related receptor alpha, nuclear, mitochondrial, oxygen, yin - yang 1, YY1, mTOR, PGC-1alpha, YY1, mitochondrial, YY1, rapamycin, mTOR, raptor, YY1, mTOR, YY1, PGC-1alpha, mTOR, mitochondrial Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.

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[ "Gene_or_gene_product", "Complex", "Cellular_component", "Simple_chemical" ]

mTOR, mitochondrial, YY1-PGC-1alpha, peroxisome - proliferator - activated receptor coactivator ( PGC)-1alpha, mitochondrial, mammalian target of rapamycin, mTOR, mTOR, mitochondrial, mTOR, mitochondrial, mTOR, rapamycin, mitochondrial, PGC-1alpha, oestrogen - related receptor alpha, nuclear, mitochondrial, oxygen, yin - yang 1, YY1, mTOR, PGC-1alpha, YY1, mitochondrial, YY1, rapamycin, mTOR, raptor, YY1, mTOR, YY1, PGC-1alpha, mTOR, mitochondrial

180_task2

Sentence: mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer. Instructions: please extract entity words from the input sentence

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial oxidative function to maintain energy homeostasis in response to nutrient and hormonal signals. An important component in the energy and nutrient pathways is mammalian target of rapamycin (mTOR), a kinase that regulates cell growth, size and survival. However, it is unknown whether and how mTOR controls mitochondrial oxidative activities. Here we show that mTOR is necessary for the maintenance of mitochondrial oxidative function. In skeletal muscle tissues and cells, the mTOR inhibitor rapamycin decreased the gene expression of the mitochondrial transcriptional regulators PGC-1alpha, oestrogen-related receptor alpha and nuclear respiratory factors, resulting in a decrease in mitochondrial gene expression and oxygen consumption. Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha. Knockdown of YY1 caused a significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha. We have therefore identified a mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function. These results have important implications for our understanding of how these pathways might be altered in metabolic diseases and cancer.

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[ "Gene_or_gene_product", "Complex", "Cellular_component", "Simple_chemical" ]

Allergy or sensitivity is a Scope, corticosteroids is a Qualifier, drug hypersensitivity or intolerance is a Scope, adverse reaction is a Condition, Cortrosyn ™ or similar test reagents is a Scope

NCT02340169_exc_task0

Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Condition, Qualifier

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Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation

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[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]

Allergy or sensitivity is a Scope, corticosteroids is a Qualifier, drug hypersensitivity or intolerance is a Scope, adverse reaction is a Condition, Cortrosyn ™ or similar test reagents is a Scope

NCT02340169_exc_task1

Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please typing these entity words according to sentence: Allergy or sensitivity, corticosteroids, drug hypersensitivity or intolerance, adverse reaction, Cortrosyn ™ or similar test reagents Options: Scope, Condition, Qualifier

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation

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[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]

Allergy or sensitivity, corticosteroids, drug hypersensitivity or intolerance, adverse reaction, Cortrosyn ™ or similar test reagents

NCT02340169_exc_task2

Sentence: Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Has other dermatological conditions that may interfere with clinical assessments Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results History of an adverse reaction to Cortrosyn™ or similar test reagents Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation

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[ "Scope", "Condition", "Qualifier", "Drug", "Procedure" ]

RAR alpha is a Protein, hRAR alpha is a Protein, retinoid - X receptor alpha is a Protein, hRXR alpha is a Protein, RXR alpha is a Protein, RXR alpha is a Protein, RAR alpha is a Protein

448_task0

Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.

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[ "Protein" ]

RAR alpha is a Protein, hRAR alpha is a Protein, retinoid - X receptor alpha is a Protein, hRXR alpha is a Protein, RXR alpha is a Protein, RXR alpha is a Protein, RAR alpha is a Protein

448_task1

Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please typing these entity words according to sentence: RAR alpha, hRAR alpha, retinoid - X receptor alpha, hRXR alpha, RXR alpha, RXR alpha, RAR alpha Options: Protein

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The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.

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[ "Protein" ]

RAR alpha, hRAR alpha, retinoid - X receptor alpha, hRXR alpha, RXR alpha, RXR alpha, RAR alpha

448_task2

Sentence: The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation. Instructions: please extract entity words from the input sentence

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The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors. OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection. The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis. RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA). The retinoids had weak or no stimulatory effects on HIV production by T-cell lines. HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids. The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone. Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells. Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells. After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells. Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation. CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs. Endogenous or exogenously administered RA may have a significant role in HIV regulation.

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[ "Protein" ]

histopathology is an umlsterm, cartilage is an umlsterm, growth plate is an umlsterm, differential diagnosis is an umlsterm, atelosteogenesis is an umlsterm

DerPathologe.80190379.eng.abstr_task0

Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .

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[ "umlsterm" ]

histopathology is an umlsterm, cartilage is an umlsterm, growth plate is an umlsterm, differential diagnosis is an umlsterm, atelosteogenesis is an umlsterm

DerPathologe.80190379.eng.abstr_task1

Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please typing these entity words according to sentence: histopathology, cartilage, growth plate, differential diagnosis, atelosteogenesis Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .

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[ "umlsterm" ]

histopathology, cartilage, growth plate, differential diagnosis, atelosteogenesis

DerPathologe.80190379.eng.abstr_task2

Sentence: The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

The authors describe the histopathology of the resting cartilage and the growth plate in a case of diastrophic dysplasia and review the differential diagnosis with pseudodiastrophic dysplasia and atelosteogenesis type II .

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[ "umlsterm" ]

clonidine hydrochloride is a IUPAC, clonidine hydrochloride is a IUPAC, noradrenaline is a TRIVIAL, clonidine is a TRIVIAL, group is a MODIFIER, clonidine hydrochloride is a IUPAC, dopamine is a TRIVIAL

example-5_task0

Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MODIFIER, TRIVIAL, IUPAC

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12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.

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[ "IUPAC", "TRIVIAL", "MODIFIER" ]

clonidine hydrochloride is a IUPAC, clonidine hydrochloride is a IUPAC, noradrenaline is a TRIVIAL, clonidine is a TRIVIAL, group is a MODIFIER, clonidine hydrochloride is a IUPAC, dopamine is a TRIVIAL

example-5_task1

Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please typing these entity words according to sentence: clonidine hydrochloride, clonidine hydrochloride, noradrenaline, clonidine, group, clonidine hydrochloride, dopamine Options: MODIFIER, TRIVIAL, IUPAC

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12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.

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[ "IUPAC", "TRIVIAL", "MODIFIER" ]

clonidine hydrochloride, clonidine hydrochloride, noradrenaline, clonidine, group, clonidine hydrochloride, dopamine

example-5_task2

Sentence: 12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits. Instructions: please extract entity words from the input sentence

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12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with the central sympathetic blocker clonidine hydrochloride could prevent the development of chronic vasospasm following experimental subarachnoid haemorrhage in rabbits and, secondly, if, parallel with the effect on cerebral arteries, changes in dopamine beta-hydroxylase concentration in the hypothalamus and brain stem could also be detected.Experimental subarachnoid haemorrhage, in concentrations of 1 ml of autologous arterial blood/1 kg of body weight was carried out on 18 New Zealand rabbits. Histological specimens were obtained by the method of perfusion fixation after the rabbits were sacrificed on day 8 after subarachnoid haemorrhage. The spastic effect of experimentally induced subarachnoid haemorrhage was determined by assessing the intensity of corrugation of the intima of the rabbit basilar artery by the previously developed method of corrugation coefficient and computer image analysis. The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.The results revealed less corrugated and smoother intima in the basilar artery and significantly lower dopamine beta-hydroxylase concentration in the control group of rabbits with sham subarachnoid haemorrhage and without any additional interventions (mean corrugation coefficient=1.123+/-0.024, P=0.35 x (-3); mean dopamine beta-hydroxylase=0.350+/-0.071, P=0.22 x (-3)), and smoother intima in the basilar artery with significantly lower concentration of dopamine beta-hydroxylase in the clonidine group (rabbits with subarachnoid haemorrhage and central alpha(2)-blocker clonidine hydrochloride at a daily dose of 0.03 mg/kg of body weight for 8 days; mean corrugation coefficient=1.177+/-0.058, P=1.7 x (-3); mean dopamine beta-hydroxylase=0.583+/-0.175, P=1.1 x (-3)). In comparison, the haemorrhage only group (rabbits with subarachnoid haemorrhage and without medication; mean corrugation coefficient=1.370+/-0.101; mean dopamine beta-hydroxylase=1.214+/-0.313) displayed intensive corrugation of the intima of the basilar artery and a significantly more intensive accumulation of dopamine beta-hydroxylase than did the control group and the clonidine group.The results of this study demonstrated that the central alpha(2)-blocker clonidine hydrochlorideeffectively prevents vasospasm, and diminishes the concentration of cerebral dopamine beta-hydroxylase in the hypothalamus and brain stem after experimental subarachnoid haemorrhage in rabbits.

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[ "IUPAC", "TRIVIAL", "MODIFIER" ]

Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, T cell antigen receptor is a Entity, nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein

546_task0

Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.

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[ "Entity", "Protein" ]

Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, T cell antigen receptor is a Entity, nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein, Nef is a Protein

546_task1

Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please typing these entity words according to sentence: Nef, Nef, Nef, Nef, T cell antigen receptor, nef, Nef, Nef, Nef, Nef Options: Entity, Protein

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.

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[ "Entity", "Protein" ]

Nef, Nef, Nef, Nef, T cell antigen receptor, nef, Nef, Nef, Nef, Nef

546_task2

Sentence: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS. Instructions: please extract entity words from the input sentence

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depended on the intracellular localization of Nef. Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor. Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional. These mutations paralleled those in other viral strains passaged in vitro. Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.

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[ "Entity", "Protein" ]

Behandlung is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, Tumorvolumen is an umlsterm, Prognosefaktoren is an umlsterm, Beckenrezidiv is an umlsterm, Tumorbiologische is an umlsterm, Marker is an umlsterm, Nachweismethoden is an umlsterm, Therapieplanung is an umlsterm, Prognose is an umlsterm, Rolle is an umlsterm, Therapieprinzipien is an umlsterm, Hysterektomie is an umlsterm, Beckens is an umlsterm, Rolle is an umlsterm, Chemotherapie is an umlsterm, Karzinomen is an umlsterm

DerPathologe.90200042.ger.abstr_task0

Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .

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[ "umlsterm" ]

Behandlung is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, Tumorvolumen is an umlsterm, Prognosefaktoren is an umlsterm, Beckenrezidiv is an umlsterm, Tumorbiologische is an umlsterm, Marker is an umlsterm, Nachweismethoden is an umlsterm, Therapieplanung is an umlsterm, Prognose is an umlsterm, Rolle is an umlsterm, Therapieprinzipien is an umlsterm, Hysterektomie is an umlsterm, Beckens is an umlsterm, Rolle is an umlsterm, Chemotherapie is an umlsterm, Karzinomen is an umlsterm

DerPathologe.90200042.ger.abstr_task1

Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please typing these entity words according to sentence: Behandlung, Therapie, Therapie, Prognose, Tumorvolumen, Prognosefaktoren, Beckenrezidiv, Tumorbiologische, Marker, Nachweismethoden, Therapieplanung, Prognose, Rolle, Therapieprinzipien, Hysterektomie, Beckens, Rolle, Chemotherapie, Karzinomen Options: umlsterm

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Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .

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[ "umlsterm" ]

Behandlung, Therapie, Therapie, Prognose, Tumorvolumen, Prognosefaktoren, Beckenrezidiv, Tumorbiologische, Marker, Nachweismethoden, Therapieplanung, Prognose, Rolle, Therapieprinzipien, Hysterektomie, Beckens, Rolle, Chemotherapie, Karzinomen

DerPathologe.90200042.ger.abstr_task2

Sentence: Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die Behandlung des histologisch gesicherten Zervixkarzinoms erfolgt unabhaengig vom histologischen Typ stadienspezifisch . Das klinische Staging ist fuer die Wahl der primaeren Therapie des Zervixkarzinoms entscheidend . Nach operativer Therapie ist die morphologische Begutachtung des Operationspraeparates die Grundlage fuer das endgueltige Staging , das weitere postoperative Vorgehen und die Prognose . Besondere Bedeutung haben Stroma- und Gefaessinvasion , Tumorvolumen und Resektatrandbefund , da diese Parameter als die wichtigsten morphologischen Prognosefaktoren ( Beckenrezidiv Fernmetastasierung , , Ueberleben ) gelten . Tumorbiologische Marker und Nachweismethoden spielen fuer die Therapieplanung und Prognose bisher keine Rolle . Klassische Therapieprinzipien sind die radikale Hysterektomie nach Wertheim-Meigs und die primaere oder adjuvante Bestrahlung des Beckens . Die Rolle der Chemotherapie ist noch zu definieren . Bei mikroinvasiven Karzinomen ist ein differenziertes , weniger invasives Vorgehen in Abhaengigkeit von den Faktoren Stromainvasion , Gefaessinvasion und Resektatrandbefund moeglich .

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[ "umlsterm" ]

Membrane receptors is a protein_family_or_group, aldosterone is a lipid, mineralocorticoid action is an other_name

87365_task0

Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_family_or_group, lipid, other_name

[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]

Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.

[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]

[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]

Membrane receptors is a protein_family_or_group, aldosterone is a lipid, mineralocorticoid action is an other_name

87365_task1

Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please typing these entity words according to sentence: Membrane receptors, aldosterone, mineralocorticoid action Options: protein_family_or_group, lipid, other_name

[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]

Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.

[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]

[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]

Membrane receptors, aldosterone, mineralocorticoid action

87365_task2

Sentence: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Instructions: please extract entity words from the input sentence

[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-lipid", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O" ]

Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.

[ "Membrane", "receptors", "for", "aldosterone", ":", "a", "novel", "pathway", "for", "mineralocorticoid", "action", "." ]

[ "cell_type", "lipid", "atom", "other_name", "protein_family_or_group", "protein_molecule", "cell_component", "other_organic_compound" ]

ichthyosis vulgaris is an umlsterm, ointment is an umlsterm, child is an umlsterm, salicylic acid is an umlsterm, body weight is an umlsterm, period is an umlsterm, patient is an umlsterm, hospital is an umlsterm, family doctor is an umlsterm, hyperventilation is an umlsterm, vomiting is an umlsterm, tinnitus is an umlsterm, vertigo is an umlsterm, Salicylate is an umlsterm, intoxication is an umlsterm, acidosis is an umlsterm, anion gap is an umlsterm, overcompensation is an umlsterm, diagnosis is an umlsterm, salicylate is an umlsterm, therapeutic is an umlsterm, diuresis is an umlsterm, sodium bicarbonate is an umlsterm, haemodialysis is an umlsterm, salicylate is an umlsterm, values is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, deficiencies is an umlsterm, Fecal incontinence is an umlsterm, ptosis is an umlsterm, strabismus is an umlsterm, right is an umlsterm, pathogenesis is an umlsterm, salicylate is an umlsterm, toxicity is an umlsterm, need is an umlsterm, therapies is an umlsterm, ichthyosis vulgaris is an umlsterm

DerHautarzt.60470624.eng.abstr_task0

Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .

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[ "umlsterm" ]

ichthyosis vulgaris is an umlsterm, ointment is an umlsterm, child is an umlsterm, salicylic acid is an umlsterm, body weight is an umlsterm, period is an umlsterm, patient is an umlsterm, hospital is an umlsterm, family doctor is an umlsterm, hyperventilation is an umlsterm, vomiting is an umlsterm, tinnitus is an umlsterm, vertigo is an umlsterm, Salicylate is an umlsterm, intoxication is an umlsterm, acidosis is an umlsterm, anion gap is an umlsterm, overcompensation is an umlsterm, diagnosis is an umlsterm, salicylate is an umlsterm, therapeutic is an umlsterm, diuresis is an umlsterm, sodium bicarbonate is an umlsterm, haemodialysis is an umlsterm, salicylate is an umlsterm, values is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, deficiencies is an umlsterm, Fecal incontinence is an umlsterm, ptosis is an umlsterm, strabismus is an umlsterm, right is an umlsterm, pathogenesis is an umlsterm, salicylate is an umlsterm, toxicity is an umlsterm, need is an umlsterm, therapies is an umlsterm, ichthyosis vulgaris is an umlsterm

DerHautarzt.60470624.eng.abstr_task1

Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please typing these entity words according to sentence: ichthyosis vulgaris, ointment, child, salicylic acid, body weight, period, patient, hospital, family doctor, hyperventilation, vomiting, tinnitus, vertigo, Salicylate, intoxication, acidosis, anion gap, overcompensation, diagnosis, salicylate, therapeutic, diuresis, sodium bicarbonate, haemodialysis, salicylate, values, therapeutic, patient, deficiencies, Fecal incontinence, ptosis, strabismus, right, pathogenesis, salicylate, toxicity, need, therapies, ichthyosis vulgaris Options: umlsterm

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In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .

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[ "umlsterm" ]

ichthyosis vulgaris, ointment, child, salicylic acid, body weight, period, patient, hospital, family doctor, hyperventilation, vomiting, tinnitus, vertigo, Salicylate, intoxication, acidosis, anion gap, overcompensation, diagnosis, salicylate, therapeutic, diuresis, sodium bicarbonate, haemodialysis, salicylate, values, therapeutic, patient, deficiencies, Fecal incontinence, ptosis, strabismus, right, pathogenesis, salicylate, toxicity, need, therapies, ichthyosis vulgaris

DerHautarzt.60470624.eng.abstr_task2

Sentence: In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]

In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed .

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[ "umlsterm" ]

actin is a Individual_protein, profilin is a Individual_protein, actin is a Gene/protein/RNA

282_task0

Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]

Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.

[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

actin is a Individual_protein, profilin is a Individual_protein, actin is a Gene/protein/RNA

282_task1

Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please typing these entity words according to sentence: actin, profilin, actin Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]

Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.

[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

actin, profilin, actin

282_task2

Sentence: Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O" ]

Three-dimensional fluorescence microscopy of the fluorescent analog of actin with a high affinity for profilin revealed that it incorporated into cortical cytoplasmic fibers and was also distributed diffusely in the non-cortical cytoplasm consistent with a bias of actin assembly near the surface of the cell.

[ "Three", "-", "dimensional", "fluorescence", "microscopy", "of", "the", "fluorescent", "analog", "of", "actin", "with", "a", "high", "affinity", "for", "profilin", "revealed", "that", "it", "incorporated", "into", "cortical", "cytoplasmic", "fibers", "and", "was", "also", "distributed", "diffusely", "in", "the", "non", "-", "cortical", "cytoplasm", "consistent", "with", "a", "bias", "of", "actin", "assembly", "near", "the", "surface", "of", "the", "cell", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

vitamin D receptor is a GENE-Y

23065592_task0

Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.

[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]

[ "GENE-Y", "CHEMICAL" ]

vitamin D receptor is a GENE-Y

23065592_task1

Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please typing these entity words according to sentence: vitamin D receptor Options: GENE-Y

[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.

[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]

[ "GENE-Y", "CHEMICAL" ]

vitamin D receptor

23065592_task2

Sentence: Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.

[ "Polymorphisms", "in", "the", "vitamin", "D", "receptor", "gene", "and", "risk", "of", "autoimmune", "thyroid", "diseases", ":", "a", "meta", "-", "analysis", "." ]

[ "GENE-Y", "CHEMICAL" ]

AT1 is a GENE-Y, olmesartan medoxomil is a CHEMICAL

16775509_task0

Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]

Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.

[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

AT1 is a GENE-Y, olmesartan medoxomil is a CHEMICAL

16775509_task1

Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please typing these entity words according to sentence: AT1, olmesartan medoxomil Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]

Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.

[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

AT1, olmesartan medoxomil

16775509_task2

Sentence: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O" ]

Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.

[ "Functional", "and", "bioenergetic", "consequences", "of", "AT1", "antagonist", "olmesartan", "medoxomil", "in", "hearts", "with", "postinfarction", "LV", "remodeling", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

Tobacco is a Plant, mental illnesses is a Disease, substance abuse disorders is a Disease, tobacco is a Plant, chronic mental illness is a Disease, tobacco is a Plant

20001818_task0

Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant

[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.

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[ "Disease", "Plant" ]

Tobacco is a Plant, mental illnesses is a Disease, substance abuse disorders is a Disease, tobacco is a Plant, chronic mental illness is a Disease, tobacco is a Plant

20001818_task1

Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please typing these entity words according to sentence: Tobacco, mental illnesses, substance abuse disorders, tobacco, chronic mental illness, tobacco Options: Disease, Plant

[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.

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[ "Disease", "Plant" ]

Tobacco, mental illnesses, substance abuse disorders, tobacco, chronic mental illness, tobacco

20001818_task2

Sentence: Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps. Instructions: please extract entity words from the input sentence

[ "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tobacco use exerts a huge toll on persons with mental illnesses and substance abuse disorders, accounting for 200,000 of the annual 443,000 annual tobacco-related deaths in the United States. Persons with chronic mental illness die 25 years earlier than the general population does, and smoking is the major contributor to that premature mortality. This population consumes 44% of all cigarettes, reflecting very high prevalence rates plus heavy smoking by users. The pattern reflects a combination of biological, psychosocial, cultural, and tobacco industry-related factors. Although provider and patient perspectives are changing, smoking has been a historically accepted part of behavioral health settings. Additional harm results from the economic burden imposed by purchasing cigarettes and enduring the stigma attached to smoking. Tailored treatment for this population involves standard cessation treatments including counseling, medications, and telephone quitlines. Further progress depends on clinician and patient education, expanded access to treatment, and the resolution of existing knowledge gaps.

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[ "Disease", "Plant" ]

cadaver is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joint is an umlsterm, joint is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joints is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, needles is an umlsterm, anatomical is an umlsterm, all is an umlsterm, ligaments is an umlsterm, posterior is an umlsterm, ligament is an umlsterm, ligament is an umlsterm, radial nerve is an umlsterm, radial artery is an umlsterm, injury is an umlsterm, vein is an umlsterm, orientation is an umlsterm, joint is an umlsterm, nerves is an umlsterm, vessels is an umlsterm, cartilage is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, cartilage is an umlsterm, joint is an umlsterm

Arthroskopie.80110276.eng.abstr_task0

Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .

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[ "umlsterm" ]

cadaver is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joint is an umlsterm, joint is an umlsterm, human is an umlsterm, hands is an umlsterm, arthroscopy is an umlsterm, joints is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, needles is an umlsterm, anatomical is an umlsterm, all is an umlsterm, ligaments is an umlsterm, posterior is an umlsterm, ligament is an umlsterm, ligament is an umlsterm, radial nerve is an umlsterm, radial artery is an umlsterm, injury is an umlsterm, vein is an umlsterm, orientation is an umlsterm, joint is an umlsterm, nerves is an umlsterm, vessels is an umlsterm, cartilage is an umlsterm, cartilage is an umlsterm, metacarpal is an umlsterm, cartilage is an umlsterm, joint is an umlsterm

Arthroskopie.80110276.eng.abstr_task1

Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please typing these entity words according to sentence: cadaver, human, hands, arthroscopy, joint, joint, human, hands, arthroscopy, joints, cartilage, metacarpal, needles, anatomical, all, ligaments, posterior, ligament, ligament, radial nerve, radial artery, injury, vein, orientation, joint, nerves, vessels, cartilage, cartilage, metacarpal, cartilage, joint Options: umlsterm

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In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .

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[ "umlsterm" ]

cadaver, human, hands, arthroscopy, joint, joint, human, hands, arthroscopy, joints, cartilage, metacarpal, needles, anatomical, all, ligaments, posterior, ligament, ligament, radial nerve, radial artery, injury, vein, orientation, joint, nerves, vessels, cartilage, cartilage, metacarpal, cartilage, joint

Arthroskopie.80110276.eng.abstr_task2

Sentence: In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

In a cadaver study on 10 human formalin-fixed hands we identified 3 different portals ( palmar , radial and dorsal ) for arthroscopy of the trapeziometacarpal joint and 1 portal ( palmar ) for the scaphotrapezial joint . In 8 cryoconserved human hands we performed standardized arthroscopy of these joints using the portals described above and arthroscopic resection of the cartilage of the trapezium and the first metacarpal . After marking the portals with needles , we made anatomical preparations of all the important structures of this region . We found slight lesions of the ligaments in 2 cases ( oblique posterior ligament and trapeziometacarpal ligament ) . We did not see any lesion of the radial nerve or the radial artery , but in one case an injury of a branch of the cephalic vein . To get the full orientation in the trapeziometacarpal joint , it is sufficient to use two of these portals . To prevent any lesion of nerves and vessels , we recommend the palmar and the radial portal . The preparation showed that 65-85% of the cartilage of the trapezium was removed and 60-75% of the cartilage in the first metacarpal . Hence , we were able to prove experimentally that arthroscopically assisted removal of the cartilage of the trapeziometacarpal joint is possible .

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[ "umlsterm" ]

between 3 to 16 years is a Value, age is a Person, undergoing is a Temporal, adenotonsillectomy is a Procedure, myringotomy is a Procedure, myringoplasty is a Procedure, ASA is a Measurement, 1 & 2 is a Value

NCT02162433_inc_task0

Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Value, Person, Procedure, Measurement

[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]

Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2

[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]

[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]

between 3 to 16 years is a Value, age is a Person, undergoing is a Temporal, adenotonsillectomy is a Procedure, myringotomy is a Procedure, myringoplasty is a Procedure, ASA is a Measurement, 1 & 2 is a Value

NCT02162433_inc_task1

Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please typing these entity words according to sentence: between 3 to 16 years, age, undergoing, adenotonsillectomy, myringotomy, myringoplasty, ASA, 1 & 2 Options: Temporal, Value, Person, Procedure, Measurement

[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]

Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2

[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]

[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]

between 3 to 16 years, age, undergoing, adenotonsillectomy, myringotomy, myringoplasty, ASA, 1 & 2

NCT02162433_inc_task2

Sentence: Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2 Instructions: please extract entity words from the input sentence

[ "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Temporal", "B-Procedure", "O", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O" ]

Patients between 3 to 16 years of age undergoing adenotonsillectomy, with or without myringotomy or myringoplasty ASA 1 & 2

[ "Patients", "between", "3", "to", "16", "years", "of", "age", "undergoing", "adenotonsillectomy", ",", "with", "or", "without", "myringotomy", "or", "myringoplasty", "\n", "ASA", "1", "&", "2", "\n" ]

[ "Scope", "Value", "Procedure", "Temporal", "Person", "Measurement" ]

phospholipases A2 is a protein, oxygen is a compound

DS.d1518_task0

Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]

These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.

[ "These", "Ca2", "+", "-independent", "phospholipases", "A2", "display", "remarkable", "specificity", "for", "the", "length", "of", "the", "sn-2", "residue", ",", "but", "this", "selectivity", "is", "lost", "as", "the", "residue", "gains", "oxygen", "functions", "." ]

[ "protein", "compound" ]

phospholipases A2 is a protein, oxygen is a compound

DS.d1518_task1

Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please typing these entity words according to sentence: phospholipases A2, oxygen Options: compound, protein

[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]

These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.

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[ "protein", "compound" ]

phospholipases A2, oxygen

DS.d1518_task2

Sentence: These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]

These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.

[ "These", "Ca2", "+", "-independent", "phospholipases", "A2", "display", "remarkable", "specificity", "for", "the", "length", "of", "the", "sn-2", "residue", ",", "but", "this", "selectivity", "is", "lost", "as", "the", "residue", "gains", "oxygen", "functions", "." ]

[ "protein", "compound" ]

Glutathione S - transferase is a Gene/protein/RNA, Tax is a Gene/protein/RNA, Tax is a Individual_protein, CBP is a Individual_protein, p300 is a Individual_protein, CREB is a Individual_protein, Tax is a Individual_protein

302_task0

Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein

[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]

Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.

[ "Glutathione", "S", "-", "transferase", "pull", "-", "down", "performed", "with", "Tax", "deletion", "mutants", "and", "peptide", "competition", "have", "localized", "the", "site", "in", "Tax", "critical", "for", "binding", "CBP", "/", "p300", "to", "a", "highly", "protease", "-", "sensitive", "region", "around", "amino", "acid", "residues", "81", "to", "95", "(", "81QRTSKTLKVLTPPIT95", ")", "which", "lies", "between", "the", "domains", "previously", "proposed", "to", "be", "important", "for", "CREB", "binding", "and", "Tax", "subunit", "dimerization", "." ]

[ "Gene/protein/RNA", "Individual_protein" ]

Glutathione S - transferase is a Gene/protein/RNA, Tax is a Gene/protein/RNA, Tax is a Individual_protein, CBP is a Individual_protein, p300 is a Individual_protein, CREB is a Individual_protein, Tax is a Individual_protein

302_task1

Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please typing these entity words according to sentence: Glutathione S - transferase, Tax, Tax, CBP, p300, CREB, Tax Options: Gene/protein/RNA, Individual_protein

[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]

Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.

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[ "Gene/protein/RNA", "Individual_protein" ]

Glutathione S - transferase, Tax, Tax, CBP, p300, CREB, Tax

302_task2

Sentence: Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Instructions: please extract entity words from the input sentence

[ "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "O", "O" ]

Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization.

[ "Glutathione", "S", "-", "transferase", "pull", "-", "down", "performed", "with", "Tax", "deletion", "mutants", "and", "peptide", "competition", "have", "localized", "the", "site", "in", "Tax", "critical", "for", "binding", "CBP", "/", "p300", "to", "a", "highly", "protease", "-", "sensitive", "region", "around", "amino", "acid", "residues", "81", "to", "95", "(", "81QRTSKTLKVLTPPIT95", ")", "which", "lies", "between", "the", "domains", "previously", "proposed", "to", "be", "important", "for", "CREB", "binding", "and", "Tax", "subunit", "dimerization", "." ]

[ "Gene/protein/RNA", "Individual_protein" ]

Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for is a Intervention_Pharmacological, malignant lymphoma is a Participant_Condition, . is a Outcome_Other, chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) is a Intervention_Pharmacological, chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ) is a Intervention_Pharmacological, 715 is a Participant_Sample-size, ML is a Participant_Condition, 281 is a Participant_Sample-size, complete remission ( CR ) is a Outcome_Physical, CR rate , CR duration , or survival is a Outcome_Physical, 388 is a Participant_Sample-size, Levamisole is a Intervention_Pharmacological, CR rates is a Outcome_Mortality, Chemoimmunotherapy with levamisole or levamisole - BCG is a Intervention_Pharmacological, CHOP chemotherapy is a Intervention_Physical

77204_task0

Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other

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Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]

Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for is a Intervention_Pharmacological, malignant lymphoma is a Participant_Condition, . is a Outcome_Other, chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) is a Intervention_Pharmacological, chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ) is a Intervention_Pharmacological, 715 is a Participant_Sample-size, ML is a Participant_Condition, 281 is a Participant_Sample-size, complete remission ( CR ) is a Outcome_Physical, CR rate , CR duration , or survival is a Outcome_Physical, 388 is a Participant_Sample-size, Levamisole is a Intervention_Pharmacological, CR rates is a Outcome_Mortality, Chemoimmunotherapy with levamisole or levamisole - BCG is a Intervention_Pharmacological, CHOP chemotherapy is a Intervention_Physical

77204_task1

Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please typing these entity words according to sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for, malignant lymphoma, ., chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ), chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ), 715, ML, 281, complete remission ( CR ), CR rate , CR duration , or survival, 388, Levamisole, CR rates, Chemoimmunotherapy with levamisole or levamisole - BCG, CHOP chemotherapy Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other

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Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]

Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for, malignant lymphoma, ., chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ), chemoimmunotherapy ( CHOP - levamisole or CHOP - levamisole - BCG ), 715, ML, 281, complete remission ( CR ), CR rate , CR duration , or survival, 388, Levamisole, CR rates, Chemoimmunotherapy with levamisole or levamisole - BCG, CHOP chemotherapy

77204_task2

Sentence: Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML . Instructions: please extract entity words from the input sentence

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Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone ; CHOP ) or chemoimmunotherapy ( CHOP-levamisole or CHOP-levamisole-BCG ) in a randomized prospective clinical trial involving 715 eligible patients with all types of malignant lymphoma ( ML ) . Of 281 evaluable patients with favorable histologic types of ML , 171 ( 61 % ) achieved complete remission ( CR ) and there was no difference in CR rate , CR duration , or survival according to the type of initial treatment . Of 388 evaluable patients with unfavorable histologic types of ML , 194 ( 50 % ) achieved CR . Levamisole appeared to adversely affect CR rates in nodular mixed and nodular large-cell lymphoma and CR duration in patients with unfavorable histology ML . Chemoimmunotherapy with levamisole or levamisole-BCG offers no advantage in terms of CR rates , CR duration , or survival compared to CHOP chemotherapy alone , and levamisole may have had an adverse impact on outcome in certain subtypes of ML .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects", "Outcome_Other" ]

stearic acid is a compound, MCP-1 is a protein

DS.d517_task0

Sentence: The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O" ]

The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4.

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[ "compound", "protein" ]