bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
psychotic is an umlsterm, patients is an umlsterm, hyperglycaemia is an umlsterm, olanzapine is an umlsterm, elevated glucose is an umlsterm, concentrations is an umlsterm, olanzapine is an umlsterm	DerNervenarzt.90700836.eng.abstr_task0	Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .	[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]	[ "umlsterm" ]
psychotic is an umlsterm, patients is an umlsterm, hyperglycaemia is an umlsterm, olanzapine is an umlsterm, elevated glucose is an umlsterm, concentrations is an umlsterm, olanzapine is an umlsterm	DerNervenarzt.90700836.eng.abstr_task1	Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please typing these entity words according to sentence: psychotic, patients, hyperglycaemia, olanzapine, elevated glucose, concentrations, olanzapine Options: umlsterm	[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .	[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]	[ "umlsterm" ]
psychotic, patients, hyperglycaemia, olanzapine, elevated glucose, concentrations, olanzapine	DerNervenarzt.90700836.eng.abstr_task2	Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .	[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]	[ "umlsterm" ]
nuclear factor - kappaB is a Entity, cytokine genes is a Entity, interleukin-1beta is a Protein, interleukin-1beta is a Protein, inhibitor - kappaB alpha is a Protein, DNA is a Entity, nuclear factor - kappaB is a Entity, nuclear factor - kappaB is a Entity, interleukin-1beta is a Protein	103_task0	Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O" ]	Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.	[ "Activation", "of", "nuclear", "factor", "-", "kappaB", "by", "lipopolysaccharide", "in", "mononuclear", "leukocytes", "is", "prevented", "by", "inhibitors", "of", "cytosolic", "phospholipase", "A2", ".", "\n", "In", "monocytes", ",", "lipopolysaccharide", "induces", "synthesis", "and", "activity", "of", "the", "85-kDa", "cytosolic", "phospholipase", "A2", ".", "This", "enzyme", "releases", "arachidonic", "acid", "and", "lyso", "-", "phospholipids", "from", "membranes", "which", "are", "metabolized", "to", "eicosanoids", "and", "platelet", "-", "activating", "-", "factor", ".", "These", "lipid", "mediators", "increase", "activity", "of", "transcription", "factors", "and", "expression", "of", "cytokine", "genes", "indicating", "a", "function", "for", "cytosolic", "phospholipase", "A2", "in", "signal", "transduction", "and", "inflammation", ".", "We", "have", "shown", "previously", "that", "trifluoromethylketone", "inhibitors", "of", "cytosolic", "phospholipase", "A2", "suppressed", "interleukin-1beta", "protein", "and", "steady", "-", "state", "mRNA", "levels", "in", "human", "lipopolysaccharide", "-", "stimulated", "peripheral", "blood", "mononuclear", "leukocytes", ".", "In", "this", "study", ",", "the", "subcellular", "mechanisms", "were", "analyzed", "by", "which", "trifluoromethylketones", "interfere", "with", "gene", "expression", ".", "We", "found", "that", "they", "reduced", "the", "initial", "interleukin-1beta", "mRNA", "transcription", "rate", "through", "prevention", "of", "degradation", "of", "inhibitor", "-", "kappaB", "alpha", ".", "Consequently", ",", "cytosolic", "activation", ",", "nuclear", "translocation", "and", "DNA", "-", "binding", "of", "nuclear", "factor", "-", "kappaB", "were", "decreased", ".", "Trifluoromethylketones", "ameliorate", "chronic", "inflammation", "in", "vivo", ".", "Thus", ",", "this", "therapeutic", "potency", "may", "reside", "in", "retention", "of", "inactive", "nuclear", "factor", "-", "kappaB", "in", "the", "cytosol", "thereby", "abrogating", "interleukin-1beta", "gene", "transcription", ".", "\n" ]	[ "Protein", "Entity" ]
nuclear factor - kappaB is a Entity, cytokine genes is a Entity, interleukin-1beta is a Protein, interleukin-1beta is a Protein, inhibitor - kappaB alpha is a Protein, DNA is a Entity, nuclear factor - kappaB is a Entity, nuclear factor - kappaB is a Entity, interleukin-1beta is a Protein	103_task1	Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please typing these entity words according to sentence: nuclear factor - kappaB, cytokine genes, interleukin-1beta, interleukin-1beta, inhibitor - kappaB alpha, DNA, nuclear factor - kappaB, nuclear factor - kappaB, interleukin-1beta Options: Entity, Protein	[ "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O" ]	Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.	[ "Activation", "of", "nuclear", "factor", "-", "kappaB", "by", "lipopolysaccharide", "in", "mononuclear", "leukocytes", "is", "prevented", "by", "inhibitors", "of", "cytosolic", "phospholipase", "A2", ".", "\n", "In", "monocytes", ",", "lipopolysaccharide", "induces", "synthesis", "and", "activity", "of", "the", "85-kDa", "cytosolic", "phospholipase", "A2", ".", "This", "enzyme", "releases", "arachidonic", "acid", "and", "lyso", "-", "phospholipids", "from", "membranes", "which", "are", "metabolized", "to", "eicosanoids", "and", "platelet", "-", "activating", "-", "factor", ".", "These", "lipid", "mediators", "increase", "activity", "of", "transcription", "factors", "and", "expression", "of", "cytokine", "genes", "indicating", "a", "function", "for", "cytosolic", "phospholipase", "A2", "in", "signal", "transduction", "and", "inflammation", ".", "We", "have", "shown", "previously", "that", "trifluoromethylketone", "inhibitors", "of", "cytosolic", "phospholipase", "A2", "suppressed", "interleukin-1beta", "protein", "and", "steady", "-", "state", "mRNA", "levels", "in", "human", "lipopolysaccharide", "-", "stimulated", "peripheral", "blood", "mononuclear", "leukocytes", ".", "In", "this", "study", ",", "the", "subcellular", "mechanisms", "were", "analyzed", "by", "which", "trifluoromethylketones", "interfere", "with", "gene", "expression", ".", "We", "found", "that", "they", "reduced", "the", "initial", "interleukin-1beta", "mRNA", "transcription", "rate", "through", "prevention", "of", "degradation", "of", "inhibitor", "-", "kappaB", "alpha", ".", "Consequently", ",", "cytosolic", "activation", ",", "nuclear", "translocation", "and", "DNA", "-", "binding", "of", "nuclear", "factor", "-", "kappaB", "were", "decreased", ".", "Trifluoromethylketones", "ameliorate", "chronic", "inflammation", "in", "vivo", ".", "Thus", ",", "this", "therapeutic", "potency", "may", "reside", "in", "retention", "of", "inactive", "nuclear", "factor", "-", "kappaB", "in", "the", "cytosol", "thereby", "abrogating", "interleukin-1beta", "gene", "transcription", ".", "\n" ]	[ "Protein", "Entity" ]
nuclear factor - kappaB, cytokine genes, interleukin-1beta, interleukin-1beta, inhibitor - kappaB alpha, DNA, nuclear factor - kappaB, nuclear factor - kappaB, interleukin-1beta	103_task2	Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O" ]	Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.	[ "Activation", "of", "nuclear", "factor", "-", "kappaB", "by", "lipopolysaccharide", "in", "mononuclear", "leukocytes", "is", "prevented", "by", "inhibitors", "of", "cytosolic", "phospholipase", "A2", ".", "\n", "In", "monocytes", ",", "lipopolysaccharide", "induces", "synthesis", "and", "activity", "of", "the", "85-kDa", "cytosolic", "phospholipase", "A2", ".", "This", "enzyme", "releases", "arachidonic", "acid", "and", "lyso", "-", "phospholipids", "from", "membranes", "which", "are", "metabolized", "to", "eicosanoids", "and", "platelet", "-", "activating", "-", "factor", ".", "These", "lipid", "mediators", "increase", "activity", "of", "transcription", "factors", "and", "expression", "of", "cytokine", "genes", "indicating", "a", "function", "for", "cytosolic", "phospholipase", "A2", "in", "signal", "transduction", "and", "inflammation", ".", "We", "have", "shown", "previously", "that", "trifluoromethylketone", "inhibitors", "of", "cytosolic", "phospholipase", "A2", "suppressed", "interleukin-1beta", "protein", "and", "steady", "-", "state", "mRNA", "levels", "in", "human", "lipopolysaccharide", "-", "stimulated", "peripheral", "blood", "mononuclear", "leukocytes", ".", "In", "this", "study", ",", "the", "subcellular", "mechanisms", "were", "analyzed", "by", "which", "trifluoromethylketones", "interfere", "with", "gene", "expression", ".", "We", "found", "that", "they", "reduced", "the", "initial", "interleukin-1beta", "mRNA", "transcription", "rate", "through", "prevention", "of", "degradation", "of", "inhibitor", "-", "kappaB", "alpha", ".", "Consequently", ",", "cytosolic", "activation", ",", "nuclear", "translocation", "and", "DNA", "-", "binding", "of", "nuclear", "factor", "-", "kappaB", "were", "decreased", ".", "Trifluoromethylketones", "ameliorate", "chronic", "inflammation", "in", "vivo", ".", "Thus", ",", "this", "therapeutic", "potency", "may", "reside", "in", "retention", "of", "inactive", "nuclear", "factor", "-", "kappaB", "in", "the", "cytosol", "thereby", "abrogating", "interleukin-1beta", "gene", "transcription", ".", "\n" ]	[ "Protein", "Entity" ]
Vorhofflimmern is an umlsterm, Personen is an umlsterm, Herzrhythmusstoerung is an umlsterm, Therapie is an umlsterm, Antikoagulantien is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm, Antiarrhythmika is an umlsterm, medikamentoesen Therapie is an umlsterm, Katheterablation is an umlsterm, Therapie is an umlsterm, Katheterablation is an umlsterm, Leitungseigenschaften is an umlsterm, AV - Knoten is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Technik is an umlsterm, Effizienz is an umlsterm, Technik is an umlsterm, Herzkammer is an umlsterm	Herzschrittmachertherapie.8009s031.ger.abstr_task0	Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .	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Vorhofflimmern is an umlsterm, Personen is an umlsterm, Herzrhythmusstoerung is an umlsterm, Therapie is an umlsterm, Antikoagulantien is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm, Antiarrhythmika is an umlsterm, medikamentoesen Therapie is an umlsterm, Katheterablation is an umlsterm, Therapie is an umlsterm, Katheterablation is an umlsterm, Leitungseigenschaften is an umlsterm, AV - Knoten is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Technik is an umlsterm, Effizienz is an umlsterm, Technik is an umlsterm, Herzkammer is an umlsterm	Herzschrittmachertherapie.8009s031.ger.abstr_task1	Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please typing these entity words according to sentence: Vorhofflimmern, Personen, Herzrhythmusstoerung, Therapie, Antikoagulantien, Morbiditaet, Mortalitaet, Patienten, Antiarrhythmika, medikamentoesen Therapie, Katheterablation, Therapie, Katheterablation, Leitungseigenschaften, AV - Knoten, Methoden, Therapie, Technik, Effizienz, Technik, Herzkammer Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .	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Vorhofflimmern, Personen, Herzrhythmusstoerung, Therapie, Antikoagulantien, Morbiditaet, Mortalitaet, Patienten, Antiarrhythmika, medikamentoesen Therapie, Katheterablation, Therapie, Katheterablation, Leitungseigenschaften, AV - Knoten, Methoden, Therapie, Technik, Effizienz, Technik, Herzkammer	Herzschrittmachertherapie.8009s031.ger.abstr_task2	Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .	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CYP3A4 is a GENE-Y, CYP3A4 is a GENE-Y, P - glycoprotein is a GENE-N, Pgp is a GENE-N, Multidrug Resistance Associated Protein 2 is a GENE-Y, MRP-2 is a GENE-Y, Breast Cancer Resistance Protein is a GENE-Y, BCRP is a GENE-Y, MonoCarboxylate Transporter 1 is a GENE-Y, MCT1 is a GENE-Y, Organic Anion Transporting Polypeptide is a GENE-N, OATP is a GENE-N, Peptide transporter 1 is a GENE-Y, PepT1 is a GENE-Y, human immunodeficiency virus protease is a GENE-N, saquinavir is a CHEMICAL, ritonavir is a CHEMICAL, darunavir is a CHEMICAL, P - glycoprotein is a GENE-N, CYP3A4 is a GENE-Y	26575_task0	Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL, GENE-Y, GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "O" ]	The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.	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CYP3A4 is a GENE-Y, CYP3A4 is a GENE-Y, P - glycoprotein is a GENE-N, Pgp is a GENE-N, Multidrug Resistance Associated Protein 2 is a GENE-Y, MRP-2 is a GENE-Y, Breast Cancer Resistance Protein is a GENE-Y, BCRP is a GENE-Y, MonoCarboxylate Transporter 1 is a GENE-Y, MCT1 is a GENE-Y, Organic Anion Transporting Polypeptide is a GENE-N, OATP is a GENE-N, Peptide transporter 1 is a GENE-Y, PepT1 is a GENE-Y, human immunodeficiency virus protease is a GENE-N, saquinavir is a CHEMICAL, ritonavir is a CHEMICAL, darunavir is a CHEMICAL, P - glycoprotein is a GENE-N, CYP3A4 is a GENE-Y	26575_task1	Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please typing these entity words according to sentence: CYP3A4, CYP3A4, P - glycoprotein, Pgp, Multidrug Resistance Associated Protein 2, MRP-2, Breast Cancer Resistance Protein, BCRP, MonoCarboxylate Transporter 1, MCT1, Organic Anion Transporting Polypeptide, OATP, Peptide transporter 1, PepT1, human immunodeficiency virus protease, saquinavir, ritonavir, darunavir, P - glycoprotein, CYP3A4 Options: CHEMICAL, GENE-Y, GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "O" ]	The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.	[ "The", "mechanisms", "responsible", "for", "garlic", "-", "drug", "interactions", "and", "their", "in", "vivo", "relevance", ".", "\n", "Garlic", "phytochemicals", "and", "garlic", "supplements", "influence", "the", "pharmacokinetic", "and", "pharmacodynamic", "behavior", "of", "concomitantly", "ingested", "drugs", ".", "In", "this", "paper", "we", "have", "summarized", "the", "mechanisms", "responsible", "for", "first", "-", "pass", "intestinal", "pharmacokinetic", "interactions", "by", "investigating", "the", "intestinal", "permeability", "of", "some", "cardiovascular", ",", "antiviral", "drugs", ",", "their", "transport", "with", "hepatic", "transporters", "and", "CYP3A4", "metabolism", ".", "Transporter", "-", "enzyme", "interplay", "was", "studied", "with", "several", "in", "vitro", "models", "of", "varying", "complexity", ":", "rat", "small", "intestine", "and", "Caco-2", "cell", "monolayers", "were", "used", "in", "studies", "of", "intestinal", "processes", ",", "and", "hepatic", "pharmacokinetics", "was", "monitored", "in", "HepG2", "cells", ",", "isolated", "rat", "hepatocytes", "and", "rat", "liver", "slices", ".", "Garlic", "phytochemicals", "from", "aged", "garlic", "extract", "modified", "the", "activities", "of", "secretory", "and", "absorptive", "transporters", "in", "both", "intestine", "and", "liver", "and", "competitively", "inhibited", "CYP3A4", "enzyme", ".", "The", "increased", "activities", "of", "the", "most", "important", "intestinal", "efflux", "(", "P", "-", "glycoprotein", "-", "Pgp", ",", "Multidrug", "Resistance", "Associated", "Protein", "2", "-", "MRP-2", ",", "Breast", "Cancer", "Resistance", "Protein", "-", "BCRP", ")", "and", "uptake", "(", "MonoCarboxylate", "Transporter", "1", "-", "MCT1", ",", "Organic", "Anion", "Transporting", "Polypeptide", "-", "OATP", ",", "Peptide", "transporter", "1", "-", "PepT1", ")", "transporters", "were", "caused", "by", "changes", "in", "electrophysiological", "membrane", "properties", "and", "by", "allosteric", "modifications", ".", "Because", "clinical", "studies", "investigating", "interactions", "between", "garlic", "and", "human", "immunodeficiency", "virus", "protease", "inhibitors", "saquinavir", "and", "ritonavir", "have", "already", "been", "performed", ",", "we", "used", "these", "in", "vivo", "data", "to", "evaluate", "the", "in", "vitro", "results", "and", "the", "reliability", "of", "the", "models", "employed", "as", "screening", "tools", "for", "forecasting", "the", "potential", "of", "first", "-", "pass", "intestinal", "metabolism", "changes", ".", "We", "also", "assessed", "the", "probability", "of", "pharmacokinetic", "interactions", "with", "garlic", "of", "the", "novel", "drug", "darunavir", "and", "other", "cardiovascular", "drugs", ".", "Finally", ",", "selected", "garlic", "phytochemicals", "were", "tested", "for", "their", "ability", "to", "influence", "P", "-", "glycoprotein", "and", "CYP3A4", "activities", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
CYP3A4, CYP3A4, P - glycoprotein, Pgp, Multidrug Resistance Associated Protein 2, MRP-2, Breast Cancer Resistance Protein, BCRP, MonoCarboxylate Transporter 1, MCT1, Organic Anion Transporting Polypeptide, OATP, Peptide transporter 1, PepT1, human immunodeficiency virus protease, saquinavir, ritonavir, darunavir, P - glycoprotein, CYP3A4	26575_task2	Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "O" ]	The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.	[ "The", "mechanisms", "responsible", "for", "garlic", "-", "drug", "interactions", "and", "their", "in", "vivo", "relevance", ".", "\n", "Garlic", "phytochemicals", "and", "garlic", "supplements", "influence", "the", "pharmacokinetic", "and", "pharmacodynamic", "behavior", "of", "concomitantly", "ingested", "drugs", ".", "In", "this", "paper", "we", "have", "summarized", "the", "mechanisms", "responsible", "for", "first", "-", "pass", "intestinal", "pharmacokinetic", "interactions", "by", "investigating", "the", "intestinal", "permeability", "of", "some", "cardiovascular", ",", "antiviral", "drugs", ",", "their", "transport", "with", "hepatic", "transporters", "and", "CYP3A4", "metabolism", ".", "Transporter", "-", "enzyme", "interplay", "was", "studied", "with", "several", "in", "vitro", "models", "of", "varying", "complexity", ":", "rat", "small", "intestine", "and", "Caco-2", "cell", "monolayers", "were", "used", "in", "studies", "of", "intestinal", "processes", ",", "and", "hepatic", "pharmacokinetics", "was", "monitored", "in", "HepG2", "cells", ",", "isolated", "rat", "hepatocytes", "and", "rat", "liver", "slices", ".", "Garlic", "phytochemicals", "from", "aged", "garlic", "extract", "modified", "the", "activities", "of", "secretory", "and", "absorptive", "transporters", "in", "both", "intestine", "and", "liver", "and", "competitively", "inhibited", "CYP3A4", "enzyme", ".", "The", "increased", "activities", "of", "the", "most", "important", "intestinal", "efflux", "(", "P", "-", "glycoprotein", "-", "Pgp", ",", "Multidrug", "Resistance", "Associated", "Protein", "2", "-", "MRP-2", ",", "Breast", "Cancer", "Resistance", "Protein", "-", "BCRP", ")", "and", "uptake", "(", "MonoCarboxylate", "Transporter", "1", "-", "MCT1", ",", "Organic", "Anion", "Transporting", "Polypeptide", "-", "OATP", ",", "Peptide", "transporter", "1", "-", "PepT1", ")", "transporters", "were", "caused", "by", "changes", "in", "electrophysiological", "membrane", "properties", "and", "by", "allosteric", "modifications", ".", "Because", "clinical", "studies", "investigating", "interactions", "between", "garlic", "and", "human", "immunodeficiency", "virus", "protease", "inhibitors", "saquinavir", "and", "ritonavir", "have", "already", "been", "performed", ",", "we", "used", "these", "in", "vivo", "data", "to", "evaluate", "the", "in", "vitro", "results", "and", "the", "reliability", "of", "the", "models", "employed", "as", "screening", "tools", "for", "forecasting", "the", "potential", "of", "first", "-", "pass", "intestinal", "metabolism", "changes", ".", "We", "also", "assessed", "the", "probability", "of", "pharmacokinetic", "interactions", "with", "garlic", "of", "the", "novel", "drug", "darunavir", "and", "other", "cardiovascular", "drugs", ".", "Finally", ",", "selected", "garlic", "phytochemicals", "were", "tested", "for", "their", "ability", "to", "influence", "P", "-", "glycoprotein", "and", "CYP3A4", "activities", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Caucasian is a Person, male is a Person, female is a Person, At least 18 years is a Value, age is a Person, Weight is a Measurement, at least 45 kg is a Value, moderate or severe is a Scope, chronic atopic dermatitis is a Condition, Good general health is a Condition, ascertained by medical history , physical examination and laboratory determinations is a Qualifier, no is a Negation, signs of clinically significant findings is a Observation, except is a Negation, chronic atopic dermatitis is a Condition, Negative is a Value, pregnancy test is a Measurement, premenopausal female is a Scope	NCT01320579_inc_task0	Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Observation, Negation, Scope, Measurement	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Person", "B-Person", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "B-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose	[ "Informed", "consent", "obtained", "prior", "to", "any", "screening", "procedure", "\n", "Caucasian", "male", "or", "female", "patient", "\n", "At", "least", "18", "years", "of", "age", "\n", "Weight", "at", "least", "45", "kg", "\n", "Patient", "with", "moderate", "or", "severe", "chronic", "atopic", "dermatitis", "\n", "Good", "general", "health", "ascertained", "by", "medical", "history", ",", "physical", "examination", "and", "laboratory", "determinations", ",", "showing", "no", "signs", "of", "clinically", "significant", "findings", ",", "except", "chronic", "atopic", "dermatitis", "\n", "Negative", "pregnancy", "test", "(", "premenopausal", "female", "patient", ")", "at", "screening", "and", "use", "of", "adequate", "contraceptive", "measures", "(", "both", "male", "and", "female", "patients", ")", "throughout", "the", "study", "and", "30", "days", "after", "the", "last", "cis", "-", "UCA", "dose", "\n" ]	[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]
Caucasian is a Person, male is a Person, female is a Person, At least 18 years is a Value, age is a Person, Weight is a Measurement, at least 45 kg is a Value, moderate or severe is a Scope, chronic atopic dermatitis is a Condition, Good general health is a Condition, ascertained by medical history , physical examination and laboratory determinations is a Qualifier, no is a Negation, signs of clinically significant findings is a Observation, except is a Negation, chronic atopic dermatitis is a Condition, Negative is a Value, pregnancy test is a Measurement, premenopausal female is a Scope	NCT01320579_inc_task1	Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please typing these entity words according to sentence: Caucasian, male, female, At least 18 years, age, Weight, at least 45 kg, moderate or severe, chronic atopic dermatitis, Good general health, ascertained by medical history , physical examination and laboratory determinations, no, signs of clinically significant findings, except, chronic atopic dermatitis, Negative, pregnancy test, premenopausal female Options: Condition, Qualifier, Value, Person, Observation, Negation, Scope, Measurement	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Person", "B-Person", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "B-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose	[ "Informed", "consent", "obtained", "prior", "to", "any", "screening", "procedure", "\n", "Caucasian", "male", "or", "female", "patient", "\n", "At", "least", "18", "years", "of", "age", "\n", "Weight", "at", "least", "45", "kg", "\n", "Patient", "with", "moderate", "or", "severe", "chronic", "atopic", "dermatitis", "\n", "Good", "general", "health", "ascertained", "by", "medical", "history", ",", "physical", "examination", "and", "laboratory", "determinations", ",", "showing", "no", "signs", "of", "clinically", "significant", "findings", ",", "except", "chronic", "atopic", "dermatitis", "\n", "Negative", "pregnancy", "test", "(", "premenopausal", "female", "patient", ")", "at", "screening", "and", "use", "of", "adequate", "contraceptive", "measures", "(", "both", "male", "and", "female", "patients", ")", "throughout", "the", "study", "and", "30", "days", "after", "the", "last", "cis", "-", "UCA", "dose", "\n" ]	[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]
Caucasian, male, female, At least 18 years, age, Weight, at least 45 kg, moderate or severe, chronic atopic dermatitis, Good general health, ascertained by medical history , physical examination and laboratory determinations, no, signs of clinically significant findings, except, chronic atopic dermatitis, Negative, pregnancy test, premenopausal female	NCT01320579_inc_task2	Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Person", "B-Person", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "O", "B-Value", "B-Measurement", "I-Measurement", "O", "B-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose	[ "Informed", "consent", "obtained", "prior", "to", "any", "screening", "procedure", "\n", "Caucasian", "male", "or", "female", "patient", "\n", "At", "least", "18", "years", "of", "age", "\n", "Weight", "at", "least", "45", "kg", "\n", "Patient", "with", "moderate", "or", "severe", "chronic", "atopic", "dermatitis", "\n", "Good", "general", "health", "ascertained", "by", "medical", "history", ",", "physical", "examination", "and", "laboratory", "determinations", ",", "showing", "no", "signs", "of", "clinically", "significant", "findings", ",", "except", "chronic", "atopic", "dermatitis", "\n", "Negative", "pregnancy", "test", "(", "premenopausal", "female", "patient", ")", "at", "screening", "and", "use", "of", "adequate", "contraceptive", "measures", "(", "both", "male", "and", "female", "patients", ")", "throughout", "the", "study", "and", "30", "days", "after", "the", "last", "cis", "-", "UCA", "dose", "\n" ]	[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]
Glucocorticoid - resistance is an other_name, peripheral - blood lymphocytes is a cell_type, glucocorticoid - receptors is a protein_family_or_group, chronic renal failure is an other_name, patients is a multi_cell	65313_task0	Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, multi_cell, other_name	[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]	Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.	[ "Glucocorticoid", "-", "resistance", "in", "peripheral", "-", "blood", "lymphocytes", "does", "not", "correlate", "with", "number", "of", "affinity", "of", "glucocorticoid", "-", "receptors", "in", "chronic", "renal", "failure", "patients", "." ]	[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]
Glucocorticoid - resistance is an other_name, peripheral - blood lymphocytes is a cell_type, glucocorticoid - receptors is a protein_family_or_group, chronic renal failure is an other_name, patients is a multi_cell	65313_task1	Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please typing these entity words according to sentence: Glucocorticoid - resistance, peripheral - blood lymphocytes, glucocorticoid - receptors, chronic renal failure, patients Options: cell_type, protein_family_or_group, multi_cell, other_name	[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]	Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.	[ "Glucocorticoid", "-", "resistance", "in", "peripheral", "-", "blood", "lymphocytes", "does", "not", "correlate", "with", "number", "of", "affinity", "of", "glucocorticoid", "-", "receptors", "in", "chronic", "renal", "failure", "patients", "." ]	[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]
Glucocorticoid - resistance, peripheral - blood lymphocytes, glucocorticoid - receptors, chronic renal failure, patients	65313_task2	Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please extract entity words from the input sentence	[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]	Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.	[ "Glucocorticoid", "-", "resistance", "in", "peripheral", "-", "blood", "lymphocytes", "does", "not", "correlate", "with", "number", "of", "affinity", "of", "glucocorticoid", "-", "receptors", "in", "chronic", "renal", "failure", "patients", "." ]	[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]
association is an umlsterm, nevus flammeus is an umlsterm, mongolian is an umlsterm, spot is an umlsterm, nevus is an umlsterm, nevus is an umlsterm, frequency is an umlsterm, nevus is an umlsterm, phacomatosis is an umlsterm, co - workers is an umlsterm, literature is an umlsterm, Phacomatosis is an umlsterm, disorder is an umlsterm, syndromes is an umlsterm, Klippel - Trenaunay syndrome is an umlsterm, Sturge - Weber syndrome is an umlsterm, woman is an umlsterm, nevus flammeus is an umlsterm, back is an umlsterm, right is an umlsterm, arm is an umlsterm, nevus is an umlsterm, back is an umlsterm	DerHautarzt.70480653.eng.abstr_task0	Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .	[ "The", "association", "of", "nevus", "flammeus", "with", "mongolian", "spot", ",", "nevus", "fuscoceruleus", ",", "nevus", "spilus", "and", ",", "with", "variable", "frequency", ",", "with", "nevus", "anemicus", "has", "been", "termed", "phacomatosis", "pigmentovascularis", ",", "a", "genodermatosis", "first", "described", "by", "Ota", "and", "co", "-", "workers", ".", "Four", "different", "combinations", "have", "been", "specified", ".", "Most", "cases", "are", "reported", "from", "the", "Japanese", "literature", ".", "Phacomatosis", "pigmentovascularis", "may", "constitute", "an", "exclusively", "cutaneous", "disorder", ",", "but", "overlapping", "with", "other", "syndromes", "like", "Klippel", "-", "Trenaunay", "syndrome", "or", "Sturge", "-", "Weber", "syndrome", "is", "also", "possible", ".", "We", "report", "a", "30-year", "-", "old", "woman", "with", "nevus", "flammeus", "on", "the", "back", "and", "right", "arm", "associated", "with", "nevus", "fuscoceruleus", "on", "the", "back", "." ]	[ "umlsterm" ]
association is an umlsterm, nevus flammeus is an umlsterm, mongolian is an umlsterm, spot is an umlsterm, nevus is an umlsterm, nevus is an umlsterm, frequency is an umlsterm, nevus is an umlsterm, phacomatosis is an umlsterm, co - workers is an umlsterm, literature is an umlsterm, Phacomatosis is an umlsterm, disorder is an umlsterm, syndromes is an umlsterm, Klippel - Trenaunay syndrome is an umlsterm, Sturge - Weber syndrome is an umlsterm, woman is an umlsterm, nevus flammeus is an umlsterm, back is an umlsterm, right is an umlsterm, arm is an umlsterm, nevus is an umlsterm, back is an umlsterm	DerHautarzt.70480653.eng.abstr_task1	Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please typing these entity words according to sentence: association, nevus flammeus, mongolian, spot, nevus, nevus, frequency, nevus, phacomatosis, co - workers, literature, Phacomatosis, disorder, syndromes, Klippel - Trenaunay syndrome, Sturge - Weber syndrome, woman, nevus flammeus, back, right, arm, nevus, back Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .	[ "The", "association", "of", "nevus", "flammeus", "with", "mongolian", "spot", ",", "nevus", "fuscoceruleus", ",", "nevus", "spilus", "and", ",", "with", "variable", "frequency", ",", "with", "nevus", "anemicus", "has", "been", "termed", "phacomatosis", "pigmentovascularis", ",", "a", "genodermatosis", "first", "described", "by", "Ota", "and", "co", "-", "workers", ".", "Four", "different", "combinations", "have", "been", "specified", ".", "Most", "cases", "are", "reported", "from", "the", "Japanese", "literature", ".", "Phacomatosis", "pigmentovascularis", "may", "constitute", "an", "exclusively", "cutaneous", "disorder", ",", "but", "overlapping", "with", "other", "syndromes", "like", "Klippel", "-", "Trenaunay", "syndrome", "or", "Sturge", "-", "Weber", "syndrome", "is", "also", "possible", ".", "We", "report", "a", "30-year", "-", "old", "woman", "with", "nevus", "flammeus", "on", "the", "back", "and", "right", "arm", "associated", "with", "nevus", "fuscoceruleus", "on", "the", "back", "." ]	[ "umlsterm" ]
association, nevus flammeus, mongolian, spot, nevus, nevus, frequency, nevus, phacomatosis, co - workers, literature, Phacomatosis, disorder, syndromes, Klippel - Trenaunay syndrome, Sturge - Weber syndrome, woman, nevus flammeus, back, right, arm, nevus, back	DerHautarzt.70480653.eng.abstr_task2	Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .	[ "The", "association", "of", "nevus", "flammeus", "with", "mongolian", "spot", ",", "nevus", "fuscoceruleus", ",", "nevus", "spilus", "and", ",", "with", "variable", "frequency", ",", "with", "nevus", "anemicus", "has", "been", "termed", "phacomatosis", "pigmentovascularis", ",", "a", "genodermatosis", "first", "described", "by", "Ota", "and", "co", "-", "workers", ".", "Four", "different", "combinations", "have", "been", "specified", ".", "Most", "cases", "are", "reported", "from", "the", "Japanese", "literature", ".", "Phacomatosis", "pigmentovascularis", "may", "constitute", "an", "exclusively", "cutaneous", "disorder", ",", "but", "overlapping", "with", "other", "syndromes", "like", "Klippel", "-", "Trenaunay", "syndrome", "or", "Sturge", "-", "Weber", "syndrome", "is", "also", "possible", ".", "We", "report", "a", "30-year", "-", "old", "woman", "with", "nevus", "flammeus", "on", "the", "back", "and", "right", "arm", "associated", "with", "nevus", "fuscoceruleus", "on", "the", "back", "." ]	[ "umlsterm" ]
psychosexual development is an umlsterm, genitalia is an umlsterm, constitution is an umlsterm, female is an umlsterm, development is an umlsterm, light is an umlsterm, classification is an umlsterm, sexual dysfunctions is an umlsterm, men is an umlsterm, women is an umlsterm, sexual dysfunctions is an umlsterm, sexuality is an umlsterm, sexual dysfunction is an umlsterm, psychoanalysis is an umlsterm, symptoms is an umlsterm, conflicts is an umlsterm	Psychotherapeut.90440279.eng.abstr_task0	Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .	[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]	[ "umlsterm" ]
psychosexual development is an umlsterm, genitalia is an umlsterm, constitution is an umlsterm, female is an umlsterm, development is an umlsterm, light is an umlsterm, classification is an umlsterm, sexual dysfunctions is an umlsterm, men is an umlsterm, women is an umlsterm, sexual dysfunctions is an umlsterm, sexuality is an umlsterm, sexual dysfunction is an umlsterm, psychoanalysis is an umlsterm, symptoms is an umlsterm, conflicts is an umlsterm	Psychotherapeut.90440279.eng.abstr_task1	Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please typing these entity words according to sentence: psychosexual development, genitalia, constitution, female, development, light, classification, sexual dysfunctions, men, women, sexual dysfunctions, sexuality, sexual dysfunction, psychoanalysis, symptoms, conflicts Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .	[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]	[ "umlsterm" ]
psychosexual development, genitalia, constitution, female, development, light, classification, sexual dysfunctions, men, women, sexual dysfunctions, sexuality, sexual dysfunction, psychoanalysis, symptoms, conflicts	Psychotherapeut.90440279.eng.abstr_task2	Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .	[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]	[ "umlsterm" ]
intraoperative complication is an umlsterm, cholecystectomy is an umlsterm, gallbladder is an umlsterm, gallstones is an umlsterm, woman is an umlsterm, tumor is an umlsterm, abscess is an umlsterm, gallstones is an umlsterm, cholecystectomy is an umlsterm, incidence is an umlsterm, abscesses is an umlsterm, gallstones is an umlsterm, symptoms is an umlsterm, diagnosis is an umlsterm, complications is an umlsterm, gallstones is an umlsterm, open is an umlsterm, procedure is an umlsterm	DerChirurg.60671047.eng.abstr_task0	Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .	[ "A", "possible", "intraoperative", "complication", "of", "laparoscopic", "cholecystectomy", "is", "opening", "of", "the", "gallbladder", "with", "subsequent", "loss", "of", "gallstones", ".", "We", "report", "on", "a", "61-year", "-", "old", "woman", "who", "was", "hospitalised", "with", "an", "obscure", "subhepatic", "tumor", ".", "Intraoperatively", "an", "abscess", "was", "found", "that", "had", "been", "caused", "by", "lost", "gallstones", "following", "after", "laparoscopic", "cholecystectomy", "3", "years", "previously", ".", "There", "is", "a", "low", "incidence", "of", "late", "abscesses", "caused", "by", "loss", "of", "gallstones", ",", "but", "because", "of", "the", "long", "latency", "and", "unspecific", "symptoms", "there", "may", "be", "problems", "in", "diagnosis", ".", "Taking", "into", "consideration", "possible", "complications", "caused", "by", "intraoperative", "loss", "of", "gallstones", ",", "all", "concrements", "should", "be", "retrieved", ",", "even", "though", "there", "is", "no", "indication", "for", "changing", "to", "an", "open", "procedure", "." ]	[ "umlsterm" ]
intraoperative complication is an umlsterm, cholecystectomy is an umlsterm, gallbladder is an umlsterm, gallstones is an umlsterm, woman is an umlsterm, tumor is an umlsterm, abscess is an umlsterm, gallstones is an umlsterm, cholecystectomy is an umlsterm, incidence is an umlsterm, abscesses is an umlsterm, gallstones is an umlsterm, symptoms is an umlsterm, diagnosis is an umlsterm, complications is an umlsterm, gallstones is an umlsterm, open is an umlsterm, procedure is an umlsterm	DerChirurg.60671047.eng.abstr_task1	Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please typing these entity words according to sentence: intraoperative complication, cholecystectomy, gallbladder, gallstones, woman, tumor, abscess, gallstones, cholecystectomy, incidence, abscesses, gallstones, symptoms, diagnosis, complications, gallstones, open, procedure Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .	[ "A", "possible", "intraoperative", "complication", "of", "laparoscopic", "cholecystectomy", "is", "opening", "of", "the", "gallbladder", "with", "subsequent", "loss", "of", "gallstones", ".", "We", "report", "on", "a", "61-year", "-", "old", "woman", "who", "was", "hospitalised", "with", "an", "obscure", "subhepatic", "tumor", ".", "Intraoperatively", "an", "abscess", "was", "found", "that", "had", "been", "caused", "by", "lost", "gallstones", "following", "after", "laparoscopic", "cholecystectomy", "3", "years", "previously", ".", "There", "is", "a", "low", "incidence", "of", "late", "abscesses", "caused", "by", "loss", "of", "gallstones", ",", "but", "because", "of", "the", "long", "latency", "and", "unspecific", "symptoms", "there", "may", "be", "problems", "in", "diagnosis", ".", "Taking", "into", "consideration", "possible", "complications", "caused", "by", "intraoperative", "loss", "of", "gallstones", ",", "all", "concrements", "should", "be", "retrieved", ",", "even", "though", "there", "is", "no", "indication", "for", "changing", "to", "an", "open", "procedure", "." ]	[ "umlsterm" ]
intraoperative complication, cholecystectomy, gallbladder, gallstones, woman, tumor, abscess, gallstones, cholecystectomy, incidence, abscesses, gallstones, symptoms, diagnosis, complications, gallstones, open, procedure	DerChirurg.60671047.eng.abstr_task2	Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .	[ "A", "possible", "intraoperative", "complication", "of", "laparoscopic", "cholecystectomy", "is", "opening", "of", "the", "gallbladder", "with", "subsequent", "loss", "of", "gallstones", ".", "We", "report", "on", "a", "61-year", "-", "old", "woman", "who", "was", "hospitalised", "with", "an", "obscure", "subhepatic", "tumor", ".", "Intraoperatively", "an", "abscess", "was", "found", "that", "had", "been", "caused", "by", "lost", "gallstones", "following", "after", "laparoscopic", "cholecystectomy", "3", "years", "previously", ".", "There", "is", "a", "low", "incidence", "of", "late", "abscesses", "caused", "by", "loss", "of", "gallstones", ",", "but", "because", "of", "the", "long", "latency", "and", "unspecific", "symptoms", "there", "may", "be", "problems", "in", "diagnosis", ".", "Taking", "into", "consideration", "possible", "complications", "caused", "by", "intraoperative", "loss", "of", "gallstones", ",", "all", "concrements", "should", "be", "retrieved", ",", "even", "though", "there", "is", "no", "indication", "for", "changing", "to", "an", "open", "procedure", "." ]	[ "umlsterm" ]
Raquel is a NOMBRE_SUJETO_ASISTENCIA, Cuenca Suarez is a NOMBRE_SUJETO_ASISTENCIA, 2783962 is a ID_SUJETO_ASISTENCIA, 28 89034672 35 is a ID_ASEGURAMIENTO, C/ Virgen del Cortijo,94 is a CALLE, Sevilla is a TERRITORIO, 41013 is a TERRITORIO, 08/03/19 is a FECHAS, España is a PAIS, 39 años is a EDAD_SUJETO_ASISTENCIA, 21/09/2012 is a FECHAS, 7435075 is a ID_CONTACTO_ASISTENCIAL, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, 41 41 57896 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 39 años is a EDAD_SUJETO_ASISTENCIA, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, Hospital Universitario Virgen del Rocío is a HOSPITAL, Avda . Manuel Siurot , s / n is a CALLE, 41013 is a TERRITORIO, Sevilla is a TERRITORIO, 955 012 000 is a NUMERO_TELEFONO, raqgores@yahoo.es is a CORREO_ELECTRONICO	85_task0	Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. 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Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. 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Raquel is a NOMBRE_SUJETO_ASISTENCIA, Cuenca Suarez is a NOMBRE_SUJETO_ASISTENCIA, 2783962 is a ID_SUJETO_ASISTENCIA, 28 89034672 35 is a ID_ASEGURAMIENTO, C/ Virgen del Cortijo,94 is a CALLE, Sevilla is a TERRITORIO, 41013 is a TERRITORIO, 08/03/19 is a FECHAS, España is a PAIS, 39 años is a EDAD_SUJETO_ASISTENCIA, 21/09/2012 is a FECHAS, 7435075 is a ID_CONTACTO_ASISTENCIAL, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, 41 41 57896 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 39 años is a EDAD_SUJETO_ASISTENCIA, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, Hospital Universitario Virgen del Rocío is a HOSPITAL, Avda . Manuel Siurot , s / n is a CALLE, 41013 is a TERRITORIO, Sevilla is a TERRITORIO, 955 012 000 is a NUMERO_TELEFONO, raqgores@yahoo.es is a CORREO_ELECTRONICO	85_task1	Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es Instructions: please typing these entity words according to sentence: Raquel, Cuenca Suarez, 2783962, 28 89034672 35, C/ Virgen del Cortijo,94, Sevilla, 41013, 08/03/19, España, 39 años, 21/09/2012, 7435075, Raquel González Resina, 41 41 57896, Mujer, 39 años, Raquel González Resina, Hospital Universitario Virgen del Rocío, Avda . 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Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. 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Raquel, Cuenca Suarez, 2783962, 28 89034672 35, C/ Virgen del Cortijo,94, Sevilla, 41013, 08/03/19, España, 39 años, 21/09/2012, 7435075, Raquel González Resina, 41 41 57896, Mujer, 39 años, Raquel González Resina, Hospital Universitario Virgen del Rocío, Avda . Manuel Siurot , s / n, 41013, Sevilla, 955 012 000, raqgores@yahoo.es	85_task2	Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. 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"I-NUMERO_TELEFONO", "O", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es	[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", "Raquel", ".", "\n", "Apellidos", ":", "Cuenca", "Suarez", ".", "\n", "NHC", ":", "2783962", ".", "\n", "NASS", ":", "28", "89034672", "35", ".", "\n", "Domicilio", ":", "C/", "Virgen", "del", "Cortijo,94", " ", ".", "\n", "Localidad/", "Provincia", ":", "Sevilla", ".", "\n", "CP", ":", "41013", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "08/03/19", ".", "\n", "País", "de", "nacimiento", ":", "España", ".", "\n", "Edad", ":", "39", "años", "Sexo", ":", "M.", "\n", "Fecha", "de", "Ingreso", ":", "21/09/2012", ".", "\n", "Servicio", ":", "Urgencias", ".", "\n", "Episodio", ":", "7435075", ".", "\n", "Médico", ":", "Raquel", "González", "Resina", " ", "NºCol", ":", "41", "41", "57896", ".", "\n", "Historia", "Actual", ":", "Mujer", "de", "39", "años", "acude", "a", "urgencias", "por", "lumbalgia", "y", 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"físico", "y", "la", "edad", "de", "la", "paciente", ",", "se", "planteó", "reconstrucción", "de", "la", "vía", "excretora", "con", "ileon", ".", "La", "evaluación", "preoperatorio", "confirmó", "retracción", "vesical", "completa", "por", "lo", "que", "se", "planteó", "la", "sustitución", "simultánea", "de", "este", "órgano", ".", "\n", "La", "técnica", "quirúrgica", "realizada", "consistió", "en", "liberar", "y", "desfuncionalizar", "60", "cm", "de", "íleon", "con", "apertura", "de", "mesocolon", "izquierdo", "para", "permitir", "la", "anastomosis", "del", "extremo", "proximal", "del", "íleon", "a", "la", "pelvis", "del", "riñón", "izquierdo", ",", "con", "sutura", "a", "puntos", "sueltos", "y", "catéter", "de", "tutorización", "doble", "J.", "Posteriormente", "se", "realizó", "cistectomía", "e", "histerectomía", "de", "útero", "miomatoso", "por", "dificultar", "la", "anastomosis", "entre", "neovejiga", "y", "uretra", ",", "con", "destubulización", "de", "30", "cm", "de", "íleon", "distal", "en", "posición", "isoperistáltica", ",", "conformando", "una", "neovejiga", "en", "\"", "U", "\"", "con", "plegadura", "tipo", "Camey", "modificada", "de", "los", "20", "cm", "finales", ".", "\n", "El", "postoperatorio", "cursa", "sin", "incidencias", "con", "buena", "evolución", "clínica", "y", "retirada", "de", "tutor", "ureteral", "a", "los", "21", "días", "de", "la", "cirugía", ".", "Cistograma", "comprobándose", "la", "estanqueidad", "de", "la", "sutura", "vesical", ",", "aunque", "se", "observa", "la", "presencia", "de", "reflujo", "vésico", "-", "ureteral", ",", "con", "alta", "presión", ".", "Tras", "retirada", "de", "nefrostomía", "y", "sonda", "vesical", "fue", "alta", "hospitalaria", "con", "micción", "horaria", "y", "escapes", "entre", "micciones", ",", "precisando", "compresas", "y", "maniobra", "de", "Credé", "para", "vaciar", "vejiga", ".", "\n", "A", "los", "seis", "meses", "cistografía", "con", "vejiga", "de", "más", "capacidad", "y", "escaso", "reflujo", ",", "persistiendo", "incontinencia", "nocturna", ".", "\n", "Durante", "las", "revisiones", "periódicas", "que", "se", "realizan", "cada", "6", "meses", ",", "la", "paciente", "nos", "muestra", "su", "satisfacción", "por", "los", "resultados", "obtenidos", "tras", "la", "cirugía", "y", "su", "mejoría", "en", "la", "calidad", "de", "vida", ",", "ya", "que", "no", "tiene", "derivación", "urinaria", "y", "los", "escapes", "de", "orina", "son", "escasos", "y", "nocturnos", ".", "\n", "En", "la", "actualidad", ",", "tras", "4", "años", "de", "la", "última", "intervención", "quirúrgica", ",", "tiene", "micciones", "cada", "2", "-", "3", "horas", "con", "continencia", "diurna", "y", "una", "compresa", "nocturna", ",", "vaciado", "vesical", "a", "expensas", "de", "maniobra", "de", "Credé", "y", "Valsalva", "sin", "residuo", "posterior", ",", "necesitando", "para", "control", "metabólico", "adecuado", "1", "g", "diario", "de", "bicarbonato", "oral", "y", "una", "Creatinina", "plasmática", "de", "1,1", "mg", "/", "dl7", ".", "\n", "Responsable", "clínico", ":", "Dra", ".", "Raquel", "González", "Resina", "Servicio", "de", "Urología", "Hospital", "Universitario", "Virgen", "del", "Rocío", "Avda", ".", "Manuel", "Siurot", ",", "s", "/", "n", "-", "41013", "Sevilla", "Tel", ".", ":", "955", "012", "000", "E", "-", "mail", "autor", ":", "raqgores@yahoo.es", "\n" ]	[ "HOSPITAL", "CALLE", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "ID_ASEGURAMIENTO", "NOMBRE_SUJETO_ASISTENCIA", "NUMERO_TELEFONO", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "ID_CONTACTO_ASISTENCIAL", "ID_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
granulocyte - macrophage colony - stimulating factor promoter is a DNA_domain_or_region, T cells is a cell_type, Elf-1 is a protein_molecule, AP-1 is a protein_molecule, transcription factors is a protein_family_or_group	17530_task0	Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_family_or_group, protein_molecule	[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]	Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.	[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]	[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]
granulocyte - macrophage colony - stimulating factor promoter is a DNA_domain_or_region, T cells is a cell_type, Elf-1 is a protein_molecule, AP-1 is a protein_molecule, transcription factors is a protein_family_or_group	17530_task1	Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please typing these entity words according to sentence: granulocyte - macrophage colony - stimulating factor promoter, T cells, Elf-1, AP-1, transcription factors Options: cell_type, DNA_domain_or_region, protein_family_or_group, protein_molecule	[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]	Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.	[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]	[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]
granulocyte - macrophage colony - stimulating factor promoter, T cells, Elf-1, AP-1, transcription factors	17530_task2	Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]	Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.	[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]	[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]
technique is an umlsterm, finger is an umlsterm, arthrodesis is an umlsterm, technique is an umlsterm, fingers is an umlsterm, method is an umlsterm, formaldehyde is an umlsterm, fingers is an umlsterm, fingers is an umlsterm, standard is an umlsterm, wire is an umlsterm, direction is an umlsterm, torque is an umlsterm, torque is an umlsterm, fracture is an umlsterm, method is an umlsterm, finger joint is an umlsterm, arthrodesis is an umlsterm	DerUnfallchirurg.91020466.eng.abstr_task0	Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .	[ "Dorsal", "tension", "band", "fixation", "is", "a", "wide", "-", "spread", "technique", "of", "finger", "arthrodesis", ".", "When", "using", "a", "resorbable", "PDS", "-", "suture", "as", "tension", "band", "fixation", "a", "costly", "implant", "removal", "is", "not", "needed", ".", "Aim", "of", "this", "study", "is", "the", "investigation", "of", "the", "primary", "stability", "of", "this", "technique", "in", "combination", "with", "the", "cup", "-", "in", "-", "cone", "-", "procedure", ".", "Freeze", "-", "preserved", "fingers", "with", "thread", "tension", "band", "fixation", "using", "the", "PDS", "-", "material", "(", "series", "1", ")", ",", "the", "same", "fixating", "method", "on", "formaldehyde", "preserved", "fingers", "(", "series", "3", ")", ",", "freeze", "-", "preserved", "fingers", "with", "a", "standard", "tension", "band", "fixating", "(", "wire", "loop", ",", "series", "2", ")", "are", "load", "in", "a", "four", "-", "point", "-", "bending", "in", "the", "direction", "of", "palmarflexion", ".", "From", "6", "degrees", "onwards", "the", "wire", "-", "tension", "-", "system", "requires", "a", "higher", "torque", "for", "bending", ",", "but", "in", "case", "of", "higher", "torque", "frequently", "leads", "to", "fracture", ".", "The", "examination", "shows", "that", "the", "thread", "-", "tension", "-", "band", "method", "by", "PDS", "-", "loop", "for", "the", "stabilisation", "of", "finger", "joint", "arthrodesis", "has", "a", "sufficient", "initial", "stability", "against", "bending", "forces", "." ]	[ "umlsterm" ]
technique is an umlsterm, finger is an umlsterm, arthrodesis is an umlsterm, technique is an umlsterm, fingers is an umlsterm, method is an umlsterm, formaldehyde is an umlsterm, fingers is an umlsterm, fingers is an umlsterm, standard is an umlsterm, wire is an umlsterm, direction is an umlsterm, torque is an umlsterm, torque is an umlsterm, fracture is an umlsterm, method is an umlsterm, finger joint is an umlsterm, arthrodesis is an umlsterm	DerUnfallchirurg.91020466.eng.abstr_task1	Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please typing these entity words according to sentence: technique, finger, arthrodesis, technique, fingers, method, formaldehyde, fingers, fingers, standard, wire, direction, torque, torque, fracture, method, finger joint, arthrodesis Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .	[ "Dorsal", "tension", "band", "fixation", "is", "a", "wide", "-", "spread", "technique", "of", "finger", "arthrodesis", ".", "When", "using", "a", "resorbable", "PDS", "-", "suture", "as", "tension", "band", "fixation", "a", "costly", "implant", "removal", "is", "not", "needed", ".", "Aim", "of", "this", "study", "is", "the", "investigation", "of", "the", "primary", "stability", "of", "this", "technique", "in", "combination", "with", "the", "cup", "-", "in", "-", "cone", "-", "procedure", ".", "Freeze", "-", "preserved", "fingers", "with", "thread", "tension", "band", "fixation", "using", "the", "PDS", "-", "material", "(", "series", "1", ")", ",", "the", "same", "fixating", "method", "on", "formaldehyde", "preserved", "fingers", "(", "series", "3", ")", ",", "freeze", "-", "preserved", "fingers", "with", "a", "standard", "tension", "band", "fixating", "(", "wire", "loop", ",", "series", "2", ")", "are", "load", "in", "a", "four", "-", "point", "-", "bending", "in", "the", "direction", "of", "palmarflexion", ".", "From", "6", "degrees", "onwards", "the", "wire", "-", "tension", "-", "system", "requires", "a", "higher", "torque", "for", "bending", ",", "but", "in", "case", "of", "higher", "torque", "frequently", "leads", "to", "fracture", ".", "The", "examination", "shows", "that", "the", "thread", "-", "tension", "-", "band", "method", "by", "PDS", "-", "loop", "for", "the", "stabilisation", "of", "finger", "joint", "arthrodesis", "has", "a", "sufficient", "initial", "stability", "against", "bending", "forces", "." ]	[ "umlsterm" ]
technique, finger, arthrodesis, technique, fingers, method, formaldehyde, fingers, fingers, standard, wire, direction, torque, torque, fracture, method, finger joint, arthrodesis	DerUnfallchirurg.91020466.eng.abstr_task2	Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .	[ "Dorsal", "tension", "band", "fixation", "is", "a", "wide", "-", "spread", "technique", "of", "finger", "arthrodesis", ".", "When", "using", "a", "resorbable", "PDS", "-", "suture", "as", "tension", "band", "fixation", "a", "costly", "implant", "removal", "is", "not", "needed", ".", "Aim", "of", "this", "study", "is", "the", "investigation", "of", "the", "primary", "stability", "of", "this", "technique", "in", "combination", "with", "the", "cup", "-", "in", "-", "cone", "-", "procedure", ".", "Freeze", "-", "preserved", "fingers", "with", "thread", "tension", "band", "fixation", "using", "the", "PDS", "-", "material", "(", "series", "1", ")", ",", "the", "same", "fixating", "method", "on", "formaldehyde", "preserved", "fingers", "(", "series", "3", ")", ",", "freeze", "-", "preserved", "fingers", "with", "a", "standard", "tension", "band", "fixating", "(", "wire", "loop", ",", "series", "2", ")", "are", "load", "in", "a", "four", "-", "point", "-", "bending", "in", "the", "direction", "of", "palmarflexion", ".", "From", "6", "degrees", "onwards", "the", "wire", "-", "tension", "-", "system", "requires", "a", "higher", "torque", "for", "bending", ",", "but", "in", "case", "of", "higher", "torque", "frequently", "leads", "to", "fracture", ".", "The", "examination", "shows", "that", "the", "thread", "-", "tension", "-", "band", "method", "by", "PDS", "-", "loop", "for", "the", "stabilisation", "of", "finger", "joint", "arthrodesis", "has", "a", "sufficient", "initial", "stability", "against", "bending", "forces", "." ]	[ "umlsterm" ]
weighted vests is a Intervention_Physical, second - grade is a Participant_Sample-size, with difficulty attending is a Participant_Condition, intervention is a Intervention_Physical, control is a Intervention_Control, time on task is a Outcome_Mental, with and without a vest is a Intervention_Other, Ten is a Participant_Sample-size, nonweighted vest is a Intervention_Other	53356_task0	Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Control, Participant_Condition, Intervention_Other, Participant_Sample-size, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .	[ "Pilot", "study", "of", "the", "effectiveness", "of", "weighted", "vests", ".", "OBJECTIVE", "In", "this", "pilot", "study", ",", "we", "determined", "the", "effectiveness", "of", "a", "weighted", "vest", "on", "attention", "to", "task", "for", "second", "-", "grade", "general", "education", "students", "with", "difficulty", "attending", ".", "METHOD", "We", "used", "an", "intervention", "and", "a", "control", "group", "and", "an", "ABA", "design", "to", "compare", "participants", "'", "percentage", "of", "time", "on", "task", "with", "and", "without", "a", "vest", ".", "Ten", "participants", "from", "nine", "elementary", "schools", "in", "a", "suburban", "Texas", "school", "district", "were", "randomly", "assigned", "to", "an", "intervention", "or", "a", "control", "group", ".", "Control", "group", "participants", "wore", "a", "nonweighted", "vest", ".", "Participants", ",", "classroom", "teachers", ",", "and", "research", "assistants", "who", "coded", "the", "data", "were", "blind", "as", "to", "the", "group", "to", "which", "the", "participants", "were", "assigned", ".", "RESULTS", "A", "repeated", "measures", "analysis", "of", "variance", "indicated", "no", "significant", "differences", "between", "groups", "or", "between", "baseline", ",", "intervention", ",", "and", "withdrawal", "conditions", ".", "CONCLUSION", "Our", "results", "indicated", "that", "the", "weighted", "vests", "were", "not", "effective", "in", "increasing", "time", "on", "task", ".", "These", "results", "should", "be", "generalized", "cautiously", "owing", "to", "the", "small", "sample", "size", "and", "participant", "selection", "process", "." ]	[ "Participant_Condition", "Intervention_Other", "Intervention_Physical", "Outcome_Mental", "Participant_Sample-size", "Intervention_Control" ]
weighted vests is a Intervention_Physical, second - grade is a Participant_Sample-size, with difficulty attending is a Participant_Condition, intervention is a Intervention_Physical, control is a Intervention_Control, time on task is a Outcome_Mental, with and without a vest is a Intervention_Other, Ten is a Participant_Sample-size, nonweighted vest is a Intervention_Other	53356_task1	Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please typing these entity words according to sentence: weighted vests, second - grade, with difficulty attending, intervention, control, time on task, with and without a vest, Ten, nonweighted vest Options: Intervention_Physical, Intervention_Control, Participant_Condition, Intervention_Other, Participant_Sample-size, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .	[ "Pilot", "study", "of", "the", "effectiveness", "of", "weighted", "vests", ".", "OBJECTIVE", "In", "this", "pilot", "study", ",", "we", "determined", "the", "effectiveness", "of", "a", "weighted", "vest", "on", "attention", "to", "task", "for", "second", "-", "grade", "general", "education", "students", "with", "difficulty", "attending", ".", "METHOD", "We", "used", "an", "intervention", "and", "a", "control", "group", "and", "an", "ABA", "design", "to", "compare", "participants", "'", "percentage", "of", "time", "on", "task", "with", "and", "without", "a", "vest", ".", "Ten", "participants", "from", "nine", "elementary", "schools", "in", "a", "suburban", "Texas", "school", "district", "were", "randomly", "assigned", "to", "an", "intervention", "or", "a", "control", "group", ".", "Control", "group", "participants", "wore", "a", "nonweighted", "vest", ".", "Participants", ",", "classroom", "teachers", ",", "and", "research", "assistants", "who", "coded", "the", "data", "were", "blind", "as", "to", "the", "group", "to", "which", "the", "participants", "were", "assigned", ".", "RESULTS", "A", "repeated", "measures", "analysis", "of", "variance", "indicated", "no", "significant", "differences", "between", "groups", "or", "between", "baseline", ",", "intervention", ",", "and", "withdrawal", "conditions", ".", "CONCLUSION", "Our", "results", "indicated", "that", "the", "weighted", "vests", "were", "not", "effective", "in", "increasing", "time", "on", "task", ".", "These", "results", "should", "be", "generalized", "cautiously", "owing", "to", "the", "small", "sample", "size", "and", "participant", "selection", "process", "." ]	[ "Participant_Condition", "Intervention_Other", "Intervention_Physical", "Outcome_Mental", "Participant_Sample-size", "Intervention_Control" ]
weighted vests, second - grade, with difficulty attending, intervention, control, time on task, with and without a vest, Ten, nonweighted vest	53356_task2	Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .	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Diagnostik is an umlsterm, Zeit is an umlsterm, Sicherheit is an umlsterm, Menschen is an umlsterm, Hirnregionen is an umlsterm, Elektrokrampftherapie is an umlsterm, Erweiterung is an umlsterm	DerNervenarzt.70680274.ger.abstr_task0	Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .	[ "Die", "transkranielle", "Magnetstimulation", "(", "TMS", ")", "ist", "ein", "Verfahren", ",", "das", "seit", "nunmehr", "einer", "Dekade", "in", "der", "neurologischen", "Diagnostik", "zur", "Untersuchung", "der", "motorischen", "Bahnsysteme", "routinemaessig", "eingesetzt", "wird", ".", "Aus", "dieser", "Zeit", "ist", "die", "TMS", "bezueglich", "der", "Sicherheit", "in", "der", "Anwendung", "am", "Menschen", "gut", "untersucht", "und", "hat", "sich", "als", "sicher", "und", "nebenwirkungsfrei", "erwiesen", ".", "Seit", "wenigen", "Jahren", "wird", "die", "Moeglichkeit", "untersucht", ",", "mittels", "der", "TMS", "nichtinvasiv", "tiefere", "Hirnregionen", "elektrisch", "zu", "stimulieren", "und", "so", ",", "in", "Analogie", "zur", "Elektrokrampftherapie", ",", "eine", "antidepressive", "Wirkung", "zu", "erzielen", ".", "Dies", "haette", "grosse", "Vorteile", ",", "da", "dieses", "Verfahren", "schonend", "und", "ohne", "Narkose", "angewendet", "werden", "kann", ".", "Mehrere", "Einzelfallanwendungen", ",", "aber", "auch", "schon", "mehrere", "klinisch", "kontrollierte", "Studien", "lassen", "z", ".", "Z.", "die", "begruendete", "Hoffnung", "zu", ",", "dass", "dieses", "Verfahren", "zu", "einer", "Erweiterung", "des", "Spektrums", "antidepressiver", "Behandlungsverfahren", "fuehren", "koennte", "." ]	[ "umlsterm" ]
Diagnostik is an umlsterm, Zeit is an umlsterm, Sicherheit is an umlsterm, Menschen is an umlsterm, Hirnregionen is an umlsterm, Elektrokrampftherapie is an umlsterm, Erweiterung is an umlsterm	DerNervenarzt.70680274.ger.abstr_task1	Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please typing these entity words according to sentence: Diagnostik, Zeit, Sicherheit, Menschen, Hirnregionen, Elektrokrampftherapie, Erweiterung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .	[ "Die", "transkranielle", "Magnetstimulation", "(", "TMS", ")", "ist", "ein", "Verfahren", ",", "das", "seit", "nunmehr", "einer", "Dekade", "in", "der", "neurologischen", "Diagnostik", "zur", "Untersuchung", "der", "motorischen", "Bahnsysteme", "routinemaessig", "eingesetzt", "wird", ".", "Aus", "dieser", "Zeit", "ist", "die", "TMS", "bezueglich", "der", "Sicherheit", "in", "der", "Anwendung", "am", "Menschen", "gut", "untersucht", "und", "hat", "sich", "als", "sicher", "und", "nebenwirkungsfrei", "erwiesen", ".", "Seit", "wenigen", "Jahren", "wird", "die", "Moeglichkeit", "untersucht", ",", "mittels", "der", "TMS", "nichtinvasiv", "tiefere", "Hirnregionen", "elektrisch", "zu", "stimulieren", "und", "so", ",", "in", "Analogie", "zur", "Elektrokrampftherapie", ",", "eine", "antidepressive", "Wirkung", "zu", "erzielen", ".", "Dies", "haette", "grosse", "Vorteile", ",", "da", "dieses", "Verfahren", "schonend", "und", "ohne", "Narkose", "angewendet", "werden", "kann", ".", "Mehrere", "Einzelfallanwendungen", ",", "aber", "auch", "schon", "mehrere", "klinisch", "kontrollierte", "Studien", "lassen", "z", ".", "Z.", "die", "begruendete", "Hoffnung", "zu", ",", "dass", "dieses", "Verfahren", "zu", "einer", "Erweiterung", "des", "Spektrums", "antidepressiver", "Behandlungsverfahren", "fuehren", "koennte", "." ]	[ "umlsterm" ]
Diagnostik, Zeit, Sicherheit, Menschen, Hirnregionen, Elektrokrampftherapie, Erweiterung	DerNervenarzt.70680274.ger.abstr_task2	Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .	[ "Die", "transkranielle", "Magnetstimulation", "(", "TMS", ")", "ist", "ein", "Verfahren", ",", "das", "seit", "nunmehr", "einer", "Dekade", "in", "der", "neurologischen", "Diagnostik", "zur", "Untersuchung", "der", "motorischen", "Bahnsysteme", "routinemaessig", "eingesetzt", "wird", ".", "Aus", "dieser", "Zeit", "ist", "die", "TMS", "bezueglich", "der", "Sicherheit", "in", "der", "Anwendung", "am", "Menschen", "gut", "untersucht", "und", "hat", "sich", "als", "sicher", "und", "nebenwirkungsfrei", "erwiesen", ".", "Seit", "wenigen", "Jahren", "wird", "die", "Moeglichkeit", "untersucht", ",", "mittels", "der", "TMS", "nichtinvasiv", "tiefere", "Hirnregionen", "elektrisch", "zu", "stimulieren", "und", "so", ",", "in", "Analogie", "zur", "Elektrokrampftherapie", ",", "eine", "antidepressive", "Wirkung", "zu", "erzielen", ".", "Dies", "haette", "grosse", "Vorteile", ",", "da", "dieses", "Verfahren", "schonend", "und", "ohne", "Narkose", "angewendet", "werden", "kann", ".", "Mehrere", "Einzelfallanwendungen", ",", "aber", "auch", "schon", "mehrere", "klinisch", "kontrollierte", "Studien", "lassen", "z", ".", "Z.", "die", "begruendete", "Hoffnung", "zu", ",", "dass", "dieses", "Verfahren", "zu", "einer", "Erweiterung", "des", "Spektrums", "antidepressiver", "Behandlungsverfahren", "fuehren", "koennte", "." ]	[ "umlsterm" ]
complications is an umlsterm, chiropractic is an umlsterm, treatments is an umlsterm, articulations is an umlsterm, contraindications is an umlsterm, dislocation is an umlsterm, associations is an umlsterm, risks is an umlsterm, findings is an umlsterm, tumor is an umlsterm, bones is an umlsterm, patient is an umlsterm	ManuelleMedizin.90370197.eng.abstr_task0	Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .	[ "Severe", "complications", "after", "chiropractic", "treatments", "rarely", "occur", ".", "They", "happen", "mostly", "when", "manipulating", "the", "atlantoaxial", "and", "the", "craniovertebral", "articulations", "or", "when", "not", "attending", "to", "the", "contraindications", "like", "partial", "dislocation", "and", "hemivertebra", ".", "Therefore", ",", "x", "-", "ray", "pictures", "from", "the", "part", "of", "the", "vertebral", "region", "to", "be", "treated", "are", "inevitable", "and", "likewise", "the", "medical", "scientific", "associations", "demand", "them", "uniformly", "to", "minimize", "the", "risks", ".", "Nevertheless", ",", "our", "case", "-", "report", "shows", "also", "inconspicuous", "radiological", "findings", "do", "not", "exclude", "local", "tumor", "infestation", "of", "the", "bones", "with", "possible", "deleterious", "results", "for", "the", "patient", "treated", "by", "the", "chiropractor", "." ]	[ "umlsterm" ]
complications is an umlsterm, chiropractic is an umlsterm, treatments is an umlsterm, articulations is an umlsterm, contraindications is an umlsterm, dislocation is an umlsterm, associations is an umlsterm, risks is an umlsterm, findings is an umlsterm, tumor is an umlsterm, bones is an umlsterm, patient is an umlsterm	ManuelleMedizin.90370197.eng.abstr_task1	Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please typing these entity words according to sentence: complications, chiropractic, treatments, articulations, contraindications, dislocation, associations, risks, findings, tumor, bones, patient Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .	[ "Severe", "complications", "after", "chiropractic", "treatments", "rarely", "occur", ".", "They", "happen", "mostly", "when", "manipulating", "the", "atlantoaxial", "and", "the", "craniovertebral", "articulations", "or", "when", "not", "attending", "to", "the", "contraindications", "like", "partial", "dislocation", "and", "hemivertebra", ".", "Therefore", ",", "x", "-", "ray", "pictures", "from", "the", "part", "of", "the", "vertebral", "region", "to", "be", "treated", "are", "inevitable", "and", "likewise", "the", "medical", "scientific", "associations", "demand", "them", "uniformly", "to", "minimize", "the", "risks", ".", "Nevertheless", ",", "our", "case", "-", "report", "shows", "also", "inconspicuous", "radiological", "findings", "do", "not", "exclude", "local", "tumor", "infestation", "of", "the", "bones", "with", "possible", "deleterious", "results", "for", "the", "patient", "treated", "by", "the", "chiropractor", "." ]	[ "umlsterm" ]
complications, chiropractic, treatments, articulations, contraindications, dislocation, associations, risks, findings, tumor, bones, patient	ManuelleMedizin.90370197.eng.abstr_task2	Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .	[ "Severe", "complications", "after", "chiropractic", "treatments", "rarely", "occur", ".", "They", "happen", "mostly", "when", "manipulating", "the", "atlantoaxial", "and", "the", "craniovertebral", "articulations", "or", "when", "not", "attending", "to", "the", "contraindications", "like", "partial", "dislocation", "and", "hemivertebra", ".", "Therefore", ",", "x", "-", "ray", "pictures", "from", "the", "part", "of", "the", "vertebral", "region", "to", "be", "treated", "are", "inevitable", "and", "likewise", "the", "medical", "scientific", "associations", "demand", "them", "uniformly", "to", "minimize", "the", "risks", ".", "Nevertheless", ",", "our", "case", "-", "report", "shows", "also", "inconspicuous", "radiological", "findings", "do", "not", "exclude", "local", "tumor", "infestation", "of", "the", "bones", "with", "possible", "deleterious", "results", "for", "the", "patient", "treated", "by", "the", "chiropractor", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, Biopsy is an umlsterm, skin is an umlsterm, patients is an umlsterm, lichen planus is an umlsterm, treatment is an umlsterm, murine is an umlsterm, monoclonal antibodies is an umlsterm, adhesion molecules is an umlsterm, contrast is an umlsterm, biopsies is an umlsterm, PUVA therapy is an umlsterm, skin is an umlsterm, HLA - DR is an umlsterm, keratinocytes is an umlsterm, cells is an umlsterm, cell - cell is an umlsterm, cell - matrix adhesion is an umlsterm, patients is an umlsterm	DerHautarzt.40450161.eng.abstr_task0	Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .	[ "Abstract", ".", "Biopsy", "specimens", "of", "involved", "and", "uninvolved", "skin", "were", "studied", "in", "four", "patients", "suffering", "from", "generalized", "lichen", "planus", "(", "LP", ")", "before", "and", "after", "successful", "oral", "PUVA", "treatment", "with", "murine", "monoclonal", "antibodies", "against", "several", "cellular", "adhesion", "molecules", ".", "In", "contrast", "to", "untreated", "LP", "lesions", ",", "in", "biopsies", "obtained", "after", "PUVA", "therapy", "from", "healed", "involved", "skin", "we", "found", "markedly", "diminished", "to", "completely", "absent", "expression", "of", "CD54(ICAM-1", ")", ",", "HLA", "-", "DR", ",", "CD11a/18(LFA-1", ")", "and", "CD49f(VLA-6", ")", "on", "keratinocytes", "and", "an", "effective", "loss", "of", "CD49a(VLA-1)-", ",", "CD49c(VLA-3)-", ",", "CD49d(VLA-4)-", ",", "CD49f(VLA-6)-", ",", "CD3-", "and", "CD8-positive", "infiltrating", "cells", ".", "Our", "data", "demonstrate", "the", "influence", "of", "PUVA", "on", "cell", "-", "cell", "and", "cell", "-", "matrix", "adhesion", "in", "patients", "with", "LP", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, Biopsy is an umlsterm, skin is an umlsterm, patients is an umlsterm, lichen planus is an umlsterm, treatment is an umlsterm, murine is an umlsterm, monoclonal antibodies is an umlsterm, adhesion molecules is an umlsterm, contrast is an umlsterm, biopsies is an umlsterm, PUVA therapy is an umlsterm, skin is an umlsterm, HLA - DR is an umlsterm, keratinocytes is an umlsterm, cells is an umlsterm, cell - cell is an umlsterm, cell - matrix adhesion is an umlsterm, patients is an umlsterm	DerHautarzt.40450161.eng.abstr_task1	Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please typing these entity words according to sentence: Abstract, Biopsy, skin, patients, lichen planus, treatment, murine, monoclonal antibodies, adhesion molecules, contrast, biopsies, PUVA therapy, skin, HLA - DR, keratinocytes, cells, cell - cell, cell - matrix adhesion, patients Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .	[ "Abstract", ".", "Biopsy", "specimens", "of", "involved", "and", "uninvolved", "skin", "were", "studied", "in", "four", "patients", "suffering", "from", "generalized", "lichen", "planus", "(", "LP", ")", "before", "and", "after", "successful", "oral", "PUVA", "treatment", "with", "murine", "monoclonal", "antibodies", "against", "several", "cellular", "adhesion", "molecules", ".", "In", "contrast", "to", "untreated", "LP", "lesions", ",", "in", "biopsies", "obtained", "after", "PUVA", "therapy", "from", "healed", "involved", "skin", "we", "found", "markedly", "diminished", "to", "completely", "absent", "expression", "of", "CD54(ICAM-1", ")", ",", "HLA", "-", "DR", ",", "CD11a/18(LFA-1", ")", "and", "CD49f(VLA-6", ")", "on", "keratinocytes", "and", "an", "effective", "loss", "of", "CD49a(VLA-1)-", ",", "CD49c(VLA-3)-", ",", "CD49d(VLA-4)-", ",", "CD49f(VLA-6)-", ",", "CD3-", "and", "CD8-positive", "infiltrating", "cells", ".", "Our", "data", "demonstrate", "the", "influence", "of", "PUVA", "on", "cell", "-", "cell", "and", "cell", "-", "matrix", "adhesion", "in", "patients", "with", "LP", "." ]	[ "umlsterm" ]
Abstract, Biopsy, skin, patients, lichen planus, treatment, murine, monoclonal antibodies, adhesion molecules, contrast, biopsies, PUVA therapy, skin, HLA - DR, keratinocytes, cells, cell - cell, cell - matrix adhesion, patients	DerHautarzt.40450161.eng.abstr_task2	Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .	[ "Abstract", ".", "Biopsy", "specimens", "of", "involved", "and", "uninvolved", "skin", "were", "studied", "in", "four", "patients", "suffering", "from", "generalized", "lichen", "planus", "(", "LP", ")", "before", "and", "after", "successful", "oral", "PUVA", "treatment", "with", "murine", "monoclonal", "antibodies", "against", "several", "cellular", "adhesion", "molecules", ".", "In", "contrast", "to", "untreated", "LP", "lesions", ",", "in", "biopsies", "obtained", "after", "PUVA", "therapy", "from", "healed", "involved", "skin", "we", "found", "markedly", "diminished", "to", "completely", "absent", "expression", "of", "CD54(ICAM-1", ")", ",", "HLA", "-", "DR", ",", "CD11a/18(LFA-1", ")", "and", "CD49f(VLA-6", ")", "on", "keratinocytes", "and", "an", "effective", "loss", "of", "CD49a(VLA-1)-", ",", "CD49c(VLA-3)-", ",", "CD49d(VLA-4)-", ",", "CD49f(VLA-6)-", ",", "CD3-", "and", "CD8-positive", "infiltrating", "cells", ".", "Our", "data", "demonstrate", "the", "influence", "of", "PUVA", "on", "cell", "-", "cell", "and", "cell", "-", "matrix", "adhesion", "in", "patients", "with", "LP", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Diagnose is an umlsterm, Vena cava inferior is an umlsterm, Therapiemodalitaeten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Lymphknoten is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Dissektion is an umlsterm, therapieinduzierten is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm	DerUrologeA.90380460.ger.abstr_task0	Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .	[ "Bei", "4", "-", "10", "%", "aller", "Patienten", "mit", "der", "Diagnose", "eines", "Nierenzellkarzinomes", "(", "NCC", ")", "wird", "die", "gleichzeitige", "Propagation", "eines", "Tumorthrombus", "in", "die", "Vena", "cava", "inferior", "bzw", ".", "das", "rechte", "Atrium", "beobachtet", ".", "Juengste", "Untersuchungen", "belegten", "die", "fehlende", "Bedeutung", "des", "Kavathrombus", "im", "Sinne", "einer", "biologischen", "Variable", "von", "unabhaengiger", "prognostischer", "Relevanz", ".", "Obwohl", "sich", "aufgrund", "der", "fehlenden", "Verfuegbarkeit", "suffizienter", "konservativ", "-", "medizinischer", "Therapiemodalitaeten", "in", "der", "Behandlung", "des", "NCC", "der", "Versuch", "einer", "moeglichst", "kompletten", "chirurgischen", "Sanierung", "von", "Patienten", "mit", "Kavathrombus", "und", "ohne", "gleichzeitigen", "Nachweis", "regionaler", "Lymphknoten", "-", "oder", "Fernmetastasen", "in", "der", "klinischen", "Routine", "weitgehend", "etabliert", "hat", ",", "bleiben", "verschiedene", "Fragen", ",", "diese", "therapeutische", "Strategie", "betreffend", ",", "Gegenstand", "aktueller", "Diskussion", ".", "In", "der", "vorliegenden", "Untersuchung", "an", "92", "Patienten", "mit", "Nierenzellkarzinom", "und", "Kavathrombus", "konnte", "gezeigt", "werden", ",", "dass", "im", "Vergleich", "mit", "konventionellen", "gefaesschirurgischen", "Behandlungsansaetzen", "insbesondere", "die", "Dissektion", "rechts", "-", "atrial", "propagierender", "Tumorthromben", "mittels", "extrakorporaler", "Zirkulation", "und", "kardialem", "Arrest", "offensichtlich", "nicht", "in", "einer", "hoeheren", "therapieinduzierten", "Mortalitaet", "resultiert", ".", "Demgegenueber", "wurde", ",", "wie", "juengst", "postuliert", ",", "eine", "aus", "dieser", "operativen", "Strategie", "resultierende", "positive", "Beeinflussung", "des", "Langzeitueberlebens", "der", "Patienten", "nicht", "beobachtet", ".", "Auch", "die", "unabhaengig", "vom", "Operationsverfahren", "wiederholt", "diskutierte", "prognostische", "Bedeutung", "der", "kranialen", "Thrombusextension", "konnte", "in", "der", "vorliegenden", "Untersuchung", "nicht", "bestaetigt", "werden", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Diagnose is an umlsterm, Vena cava inferior is an umlsterm, Therapiemodalitaeten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Lymphknoten is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Dissektion is an umlsterm, therapieinduzierten is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm	DerUrologeA.90380460.ger.abstr_task1	Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please typing these entity words according to sentence: Patienten, Diagnose, Vena cava inferior, Therapiemodalitaeten, Behandlung, Patienten, Lymphknoten, Fernmetastasen, Patienten, Dissektion, therapieinduzierten, Mortalitaet, Patienten Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .	[ "Bei", "4", "-", "10", "%", "aller", "Patienten", "mit", "der", "Diagnose", "eines", "Nierenzellkarzinomes", "(", "NCC", ")", "wird", "die", "gleichzeitige", "Propagation", "eines", "Tumorthrombus", "in", "die", "Vena", "cava", "inferior", "bzw", ".", "das", "rechte", "Atrium", "beobachtet", ".", "Juengste", "Untersuchungen", "belegten", "die", "fehlende", "Bedeutung", "des", "Kavathrombus", "im", "Sinne", "einer", "biologischen", "Variable", "von", "unabhaengiger", "prognostischer", "Relevanz", ".", "Obwohl", "sich", "aufgrund", "der", "fehlenden", "Verfuegbarkeit", "suffizienter", "konservativ", "-", "medizinischer", "Therapiemodalitaeten", "in", "der", "Behandlung", "des", "NCC", "der", "Versuch", "einer", "moeglichst", "kompletten", "chirurgischen", "Sanierung", "von", "Patienten", "mit", "Kavathrombus", "und", "ohne", "gleichzeitigen", "Nachweis", "regionaler", "Lymphknoten", "-", "oder", "Fernmetastasen", "in", "der", "klinischen", "Routine", "weitgehend", "etabliert", "hat", ",", "bleiben", "verschiedene", "Fragen", ",", "diese", "therapeutische", "Strategie", "betreffend", ",", "Gegenstand", "aktueller", "Diskussion", ".", "In", "der", "vorliegenden", "Untersuchung", "an", "92", "Patienten", "mit", "Nierenzellkarzinom", "und", "Kavathrombus", "konnte", "gezeigt", "werden", ",", "dass", "im", "Vergleich", "mit", "konventionellen", "gefaesschirurgischen", "Behandlungsansaetzen", "insbesondere", "die", "Dissektion", "rechts", "-", "atrial", "propagierender", "Tumorthromben", "mittels", "extrakorporaler", "Zirkulation", "und", "kardialem", "Arrest", "offensichtlich", "nicht", "in", "einer", "hoeheren", "therapieinduzierten", "Mortalitaet", "resultiert", ".", "Demgegenueber", "wurde", ",", "wie", "juengst", "postuliert", ",", "eine", "aus", "dieser", "operativen", "Strategie", "resultierende", "positive", "Beeinflussung", "des", "Langzeitueberlebens", "der", "Patienten", "nicht", "beobachtet", ".", "Auch", "die", "unabhaengig", "vom", "Operationsverfahren", "wiederholt", "diskutierte", "prognostische", "Bedeutung", "der", "kranialen", "Thrombusextension", "konnte", "in", "der", "vorliegenden", "Untersuchung", "nicht", "bestaetigt", "werden", "." ]	[ "umlsterm" ]
Patienten, Diagnose, Vena cava inferior, Therapiemodalitaeten, Behandlung, Patienten, Lymphknoten, Fernmetastasen, Patienten, Dissektion, therapieinduzierten, Mortalitaet, Patienten	DerUrologeA.90380460.ger.abstr_task2	Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .	[ "Bei", "4", "-", "10", "%", "aller", "Patienten", "mit", "der", "Diagnose", "eines", "Nierenzellkarzinomes", "(", "NCC", ")", "wird", "die", "gleichzeitige", "Propagation", "eines", "Tumorthrombus", "in", "die", "Vena", "cava", "inferior", "bzw", ".", "das", "rechte", "Atrium", "beobachtet", ".", "Juengste", "Untersuchungen", "belegten", "die", "fehlende", "Bedeutung", "des", "Kavathrombus", "im", "Sinne", "einer", "biologischen", "Variable", "von", "unabhaengiger", "prognostischer", "Relevanz", ".", "Obwohl", "sich", "aufgrund", "der", "fehlenden", "Verfuegbarkeit", "suffizienter", "konservativ", "-", "medizinischer", "Therapiemodalitaeten", "in", "der", "Behandlung", "des", "NCC", "der", "Versuch", "einer", "moeglichst", "kompletten", "chirurgischen", "Sanierung", "von", "Patienten", "mit", "Kavathrombus", "und", "ohne", "gleichzeitigen", "Nachweis", "regionaler", "Lymphknoten", "-", "oder", "Fernmetastasen", "in", "der", "klinischen", "Routine", "weitgehend", "etabliert", "hat", ",", "bleiben", "verschiedene", "Fragen", ",", "diese", "therapeutische", "Strategie", "betreffend", ",", "Gegenstand", "aktueller", "Diskussion", ".", "In", "der", "vorliegenden", "Untersuchung", "an", "92", "Patienten", "mit", "Nierenzellkarzinom", "und", "Kavathrombus", "konnte", "gezeigt", "werden", ",", "dass", "im", "Vergleich", "mit", "konventionellen", "gefaesschirurgischen", "Behandlungsansaetzen", "insbesondere", "die", "Dissektion", "rechts", "-", "atrial", "propagierender", "Tumorthromben", "mittels", "extrakorporaler", "Zirkulation", "und", "kardialem", "Arrest", "offensichtlich", "nicht", "in", "einer", "hoeheren", "therapieinduzierten", "Mortalitaet", "resultiert", ".", "Demgegenueber", "wurde", ",", "wie", "juengst", "postuliert", ",", "eine", "aus", "dieser", "operativen", "Strategie", "resultierende", "positive", "Beeinflussung", "des", "Langzeitueberlebens", "der", "Patienten", "nicht", "beobachtet", ".", "Auch", "die", "unabhaengig", "vom", "Operationsverfahren", "wiederholt", "diskutierte", "prognostische", "Bedeutung", "der", "kranialen", "Thrombusextension", "konnte", "in", "der", "vorliegenden", "Untersuchung", "nicht", "bestaetigt", "werden", "." ]	[ "umlsterm" ]
pulp is a Tissue, pulp is a Tissue, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulpal is a Tissue, tooth is a Organ, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, pulp is a Tissue	PMID-18565374_task0	Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Tissue, Organ	[ "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Pathological_formation", "O", "O", "B-Organ", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O" ]	Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.	[ "Contemporary", "perspectives", "on", "vital", "pulp", "therapy", ":", "views", "from", "the", "endodontists", "and", "pediatric", "dentists", ".", "\n", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "level", "of", "agreement", "between", "pediatric", "dentists", "and", "endodontists", "at", "a", "pulp", "therapy", "symposium", "conjointly", "sponsored", "by", "the", "American", "Association", "of", "Endodontists", "(", "AAE", ")", "and", "the", "American", "Academy", "of", "Pediatric", "Dentistry", "(", "AAPD", ")", "on", "November", "2", "-", "3", ",", "2007", ".", "Presymposium", "and", "postsymposium", "tests", "were", "administered", ",", "and", "respondent", "answers", "were", "compared", "between", "pediatric", "dentists", "and", "endodontists", ".", "Opinions", "on", "3", "areas", "were", "sought", ":", "pulp", "therapy", "for", "cariously", "involved", "primary", "teeth", ";", "indirect", "pulp", "treatment", "(", "IPT", ")", "for", "cariously", "involved", "immature", "permanent", "teeth", ";", "and", "innovative", "treatment", "options", "including", "pulpal", "revascularization", "and", "regeneration", ".", "Results", "were", "analyzed", "with", "chi2", "tests", ".", "Comparisons", "of", "presymposium", "and", "postsymposium", "responses", "and", "between", "the", "2", "groups", "of", "attendees", "indicated", "that", "the", "pediatric", "dentistry", "and", "endodontic", "communities", "agree", "that", "formocresol", "will", "be", "replaced", "as", "a", "primary", "tooth", "pulpotomy", "agent", ",", "that", "mineral", "trioxide", "is", "the", "first", "choice", "to", "take", "its", "place", ",", "that", "IPT", "in", "primary", "teeth", "holds", "hope", "as", "a", "replacement", "for", "pulpotomy", ",", "and", "that", "IPT", "is", "an", "acceptable", "pulp", "therapy", "technique", "for", "cariously", "involved", "young", "permanent", "teeth", ".", "Both", "groups", "believe", "that", "pulp", "revascularization", "and", "regeneration", "will", "be", "viable", "treatment", "modalities", "in", "the", "future", ".", "The", "AAE", "and", "the", "AAPD", "are", "positioned", "to", "begin", "preparation", "of", "best", "practice", "guidelines", "that", "share", "common", "language", "and", "treatment", "recommendations", "for", "pulp", "therapies", "performed", "by", "both", "specialties", ".", "\n" ]	[ "Pathological_formation", "Tissue", "Organ" ]
pulp is a Tissue, pulp is a Tissue, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulpal is a Tissue, tooth is a Organ, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, pulp is a Tissue	PMID-18565374_task1	Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please typing these entity words according to sentence: pulp, pulp, pulp, cariously, teeth, pulp, cariously, teeth, pulpal, tooth, teeth, pulp, cariously, teeth, pulp, pulp Options: Pathological_formation, Tissue, Organ	[ "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Pathological_formation", "O", "O", "B-Organ", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O" ]	Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.	[ "Contemporary", "perspectives", "on", "vital", "pulp", "therapy", ":", "views", "from", "the", "endodontists", "and", "pediatric", "dentists", ".", "\n", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "level", "of", "agreement", "between", "pediatric", "dentists", "and", "endodontists", "at", "a", "pulp", "therapy", "symposium", "conjointly", "sponsored", "by", "the", "American", "Association", "of", "Endodontists", "(", "AAE", ")", "and", "the", "American", "Academy", "of", "Pediatric", "Dentistry", "(", "AAPD", ")", "on", "November", "2", "-", "3", ",", "2007", ".", "Presymposium", "and", "postsymposium", "tests", "were", "administered", ",", "and", "respondent", "answers", "were", "compared", "between", "pediatric", "dentists", "and", "endodontists", ".", "Opinions", "on", "3", "areas", "were", "sought", ":", "pulp", "therapy", "for", "cariously", "involved", "primary", "teeth", ";", "indirect", "pulp", "treatment", "(", "IPT", ")", "for", "cariously", "involved", "immature", "permanent", "teeth", ";", "and", "innovative", "treatment", "options", "including", "pulpal", "revascularization", "and", "regeneration", ".", "Results", "were", "analyzed", "with", "chi2", "tests", ".", "Comparisons", "of", "presymposium", "and", "postsymposium", "responses", "and", "between", "the", "2", "groups", "of", "attendees", "indicated", "that", "the", "pediatric", "dentistry", "and", "endodontic", "communities", "agree", "that", "formocresol", "will", "be", "replaced", "as", "a", "primary", "tooth", "pulpotomy", "agent", ",", "that", "mineral", "trioxide", "is", "the", "first", "choice", "to", "take", "its", "place", ",", "that", "IPT", "in", "primary", "teeth", "holds", "hope", "as", "a", "replacement", "for", "pulpotomy", ",", "and", "that", "IPT", "is", "an", "acceptable", "pulp", "therapy", "technique", "for", "cariously", "involved", "young", "permanent", "teeth", ".", "Both", "groups", "believe", "that", "pulp", "revascularization", "and", "regeneration", "will", "be", "viable", "treatment", "modalities", "in", "the", "future", ".", "The", "AAE", "and", "the", "AAPD", "are", "positioned", "to", "begin", "preparation", "of", "best", "practice", "guidelines", "that", "share", "common", "language", "and", "treatment", "recommendations", "for", "pulp", "therapies", "performed", "by", "both", "specialties", ".", "\n" ]	[ "Pathological_formation", "Tissue", "Organ" ]
pulp, pulp, pulp, cariously, teeth, pulp, cariously, teeth, pulpal, tooth, teeth, pulp, cariously, teeth, pulp, pulp	PMID-18565374_task2	Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Pathological_formation", "O", "O", "B-Organ", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O" ]	Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.	[ "Contemporary", "perspectives", "on", "vital", "pulp", "therapy", ":", "views", "from", "the", "endodontists", "and", "pediatric", "dentists", ".", "\n", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "level", "of", "agreement", "between", "pediatric", "dentists", "and", "endodontists", "at", "a", "pulp", "therapy", "symposium", "conjointly", "sponsored", "by", "the", "American", "Association", "of", "Endodontists", "(", "AAE", ")", "and", "the", "American", "Academy", "of", "Pediatric", "Dentistry", "(", "AAPD", ")", "on", "November", "2", "-", "3", ",", "2007", ".", "Presymposium", "and", "postsymposium", "tests", "were", "administered", ",", "and", "respondent", "answers", "were", "compared", "between", "pediatric", "dentists", "and", "endodontists", ".", "Opinions", "on", "3", "areas", "were", "sought", ":", "pulp", "therapy", "for", "cariously", "involved", "primary", "teeth", ";", "indirect", "pulp", "treatment", "(", "IPT", ")", "for", "cariously", "involved", "immature", "permanent", "teeth", ";", "and", "innovative", "treatment", "options", "including", "pulpal", "revascularization", "and", "regeneration", ".", "Results", "were", "analyzed", "with", "chi2", "tests", ".", "Comparisons", "of", "presymposium", "and", "postsymposium", "responses", "and", "between", "the", "2", "groups", "of", "attendees", "indicated", "that", "the", "pediatric", "dentistry", "and", "endodontic", "communities", "agree", "that", "formocresol", "will", "be", "replaced", "as", "a", "primary", "tooth", "pulpotomy", "agent", ",", "that", "mineral", "trioxide", "is", "the", "first", "choice", "to", "take", "its", "place", ",", "that", "IPT", "in", "primary", "teeth", "holds", "hope", "as", "a", "replacement", "for", "pulpotomy", ",", "and", "that", "IPT", "is", "an", "acceptable", "pulp", "therapy", "technique", "for", "cariously", "involved", "young", "permanent", "teeth", ".", "Both", "groups", "believe", "that", "pulp", "revascularization", "and", "regeneration", "will", "be", "viable", "treatment", "modalities", "in", "the", "future", ".", "The", "AAE", "and", "the", "AAPD", "are", "positioned", "to", "begin", "preparation", "of", "best", "practice", "guidelines", "that", "share", "common", "language", "and", "treatment", "recommendations", "for", "pulp", "therapies", "performed", "by", "both", "specialties", ".", "\n" ]	[ "Pathological_formation", "Tissue", "Organ" ]
actin - binding protein is a Gene/protein/RNA, talin is a Gene/protein/RNA, pp60src is a Gene/protein/RNA	36_task0	Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).	[ "Addition", "of", "EGTA", "(", "3", "mM", ")", "to", "the", "extracellular", "media", "completely", "inhibited", "the", "cleavage", "of", "actin", "-", "binding", "protein", ",", "talin", ",", "and", "pp60src", "in", "response", "to", "A23187", "(", "1", "microM", ")", "." ]	[ "Gene/protein/RNA" ]
actin - binding protein is a Gene/protein/RNA, talin is a Gene/protein/RNA, pp60src is a Gene/protein/RNA	36_task1	Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please typing these entity words according to sentence: actin - binding protein, talin, pp60src Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).	[ "Addition", "of", "EGTA", "(", "3", "mM", ")", "to", "the", "extracellular", "media", "completely", "inhibited", "the", "cleavage", "of", "actin", "-", "binding", "protein", ",", "talin", ",", "and", "pp60src", "in", "response", "to", "A23187", "(", "1", "microM", ")", "." ]	[ "Gene/protein/RNA" ]
actin - binding protein, talin, pp60src	36_task2	Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).	[ "Addition", "of", "EGTA", "(", "3", "mM", ")", "to", "the", "extracellular", "media", "completely", "inhibited", "the", "cleavage", "of", "actin", "-", "binding", "protein", ",", "talin", ",", "and", "pp60src", "in", "response", "to", "A23187", "(", "1", "microM", ")", "." ]	[ "Gene/protein/RNA" ]
rivastigmine is a CHEMICAL, acetylcholine is a CHEMICAL, acetylcholinesterase is a GENE-Y, AchE is a GENE-Y, C - reactive protein is a GENE-Y, CRP is a GENE-Y, nuclear factor kappa - B is a GENE-N, NF - κB is a GENE-N, monocyte chemoattractant protein-1 is a GENE-Y, MCP-1 is a GENE-Y, AlCl3 is a CHEMICAL, AchE is a GENE-Y, CRP is a GENE-Y, NF - κB is a GENE-N, MCP-1 is a GENE-Y	13699_task0	Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. 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Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.	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rivastigmine is a CHEMICAL, acetylcholine is a CHEMICAL, acetylcholinesterase is a GENE-Y, AchE is a GENE-Y, C - reactive protein is a GENE-Y, CRP is a GENE-Y, nuclear factor kappa - B is a GENE-N, NF - κB is a GENE-N, monocyte chemoattractant protein-1 is a GENE-Y, MCP-1 is a GENE-Y, AlCl3 is a CHEMICAL, AchE is a GENE-Y, CRP is a GENE-Y, NF - κB is a GENE-N, MCP-1 is a GENE-Y	13699_task1	Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. Instructions: please typing these entity words according to sentence: rivastigmine, acetylcholine, acetylcholinesterase, AchE, C - reactive protein, CRP, nuclear factor kappa - B, NF - κB, monocyte chemoattractant protein-1, MCP-1, AlCl3, AchE, CRP, NF - κB, MCP-1 Options: GENE-N, GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.	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rivastigmine, acetylcholine, acetylcholinesterase, AchE, C - reactive protein, CRP, nuclear factor kappa - B, NF - κB, monocyte chemoattractant protein-1, MCP-1, AlCl3, AchE, CRP, NF - κB, MCP-1	13699_task2	Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.	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Patienten is an umlsterm, Pharmaka is an umlsterm, Medikamenten is an umlsterm, Gensequenzen is an umlsterm, ionisierender Strahlung is an umlsterm, Patientenzahlen is an umlsterm, Strahlentherapie is an umlsterm, Therapie is an umlsterm, Therapieform is an umlsterm	ZfuerKardiologie.8087s166.ger.abstr_task0	Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .	[ "Die", "Restenose", "nach", "Koronarangioplastie", "ist", "ein", "klinisches", "Problem", ",", "welches", "bei", "20", "-", "50", "%", "der", "behandelten", "Patienten", "auftritt", ".", "Es", "zeigte", "sich", "in", "den", "vergangenen", "Jahren", ",", "dass", "durch", "die", "systemische", "Gabe", "einer", "Vielzahl", "von", "Pharmaka", "die", "Restenoserate", "unter", "klinischen", "Bedingungen", "nicht", "signifikant", "gesenkt", "werden", "kann", ".", "Neue", "vielversprechende", "Ansaetze", ",", "eroeffnen", "sich", "durch", "die", "lokale", ",", "kathetergestuetzte", "Applikation", "von", "Medikamenten", ",", "von", "antiproliferativ", "wirkenden", "Gensequenzen", "oder", "von", "ionisierender", "Strahlung", ".", "Experimentelle", "Untersuchungen", "und", "vorlaeufige", "klinische", "Studien", "mit", "kleinen", "Patientenzahlen", "legen", "nahe", ",", "dass", "durch", "die", "kathetergestuetzte", "Strahlentherapie", "eine", "sichere", "und", "effektive", "Therapie", "der", "Restenose", "moeglich", "ist", ".", "Weitere", "randomisierte", ",", "multizentrische", "Studien", "mit", "langer", "Nachbeobachtungszeit", "muessen", "jedoch", "folgen", ",", "bevor", "diese", "Therapieform", "generell", "empfohlen", "werden", "kann", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Pharmaka is an umlsterm, Medikamenten is an umlsterm, Gensequenzen is an umlsterm, ionisierender Strahlung is an umlsterm, Patientenzahlen is an umlsterm, Strahlentherapie is an umlsterm, Therapie is an umlsterm, Therapieform is an umlsterm	ZfuerKardiologie.8087s166.ger.abstr_task1	Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please typing these entity words according to sentence: Patienten, Pharmaka, Medikamenten, Gensequenzen, ionisierender Strahlung, Patientenzahlen, Strahlentherapie, Therapie, Therapieform Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .	[ "Die", "Restenose", "nach", "Koronarangioplastie", "ist", "ein", "klinisches", "Problem", ",", "welches", "bei", "20", "-", "50", "%", "der", "behandelten", "Patienten", "auftritt", ".", "Es", "zeigte", "sich", "in", "den", "vergangenen", "Jahren", ",", "dass", "durch", "die", "systemische", "Gabe", "einer", "Vielzahl", "von", "Pharmaka", "die", "Restenoserate", "unter", "klinischen", "Bedingungen", "nicht", "signifikant", "gesenkt", "werden", "kann", ".", "Neue", "vielversprechende", "Ansaetze", ",", "eroeffnen", "sich", "durch", "die", "lokale", ",", "kathetergestuetzte", "Applikation", "von", "Medikamenten", ",", "von", "antiproliferativ", "wirkenden", "Gensequenzen", "oder", "von", "ionisierender", "Strahlung", ".", "Experimentelle", "Untersuchungen", "und", "vorlaeufige", "klinische", "Studien", "mit", "kleinen", "Patientenzahlen", "legen", "nahe", ",", "dass", "durch", "die", "kathetergestuetzte", "Strahlentherapie", "eine", "sichere", "und", "effektive", "Therapie", "der", "Restenose", "moeglich", "ist", ".", "Weitere", "randomisierte", ",", "multizentrische", "Studien", "mit", "langer", "Nachbeobachtungszeit", "muessen", "jedoch", "folgen", ",", "bevor", "diese", "Therapieform", "generell", "empfohlen", "werden", "kann", "." ]	[ "umlsterm" ]
Patienten, Pharmaka, Medikamenten, Gensequenzen, ionisierender Strahlung, Patientenzahlen, Strahlentherapie, Therapie, Therapieform	ZfuerKardiologie.8087s166.ger.abstr_task2	Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .	[ "Die", "Restenose", "nach", "Koronarangioplastie", "ist", "ein", "klinisches", "Problem", ",", "welches", "bei", "20", "-", "50", "%", "der", "behandelten", "Patienten", "auftritt", ".", "Es", "zeigte", "sich", "in", "den", "vergangenen", "Jahren", ",", "dass", "durch", "die", "systemische", "Gabe", "einer", "Vielzahl", "von", "Pharmaka", "die", "Restenoserate", "unter", "klinischen", "Bedingungen", "nicht", "signifikant", "gesenkt", "werden", "kann", ".", "Neue", "vielversprechende", "Ansaetze", ",", "eroeffnen", "sich", "durch", "die", "lokale", ",", "kathetergestuetzte", "Applikation", "von", "Medikamenten", ",", "von", "antiproliferativ", "wirkenden", "Gensequenzen", "oder", "von", "ionisierender", "Strahlung", ".", "Experimentelle", "Untersuchungen", "und", "vorlaeufige", "klinische", "Studien", "mit", "kleinen", "Patientenzahlen", "legen", "nahe", ",", "dass", "durch", "die", "kathetergestuetzte", "Strahlentherapie", "eine", "sichere", "und", "effektive", "Therapie", "der", "Restenose", "moeglich", "ist", ".", "Weitere", "randomisierte", ",", "multizentrische", "Studien", "mit", "langer", "Nachbeobachtungszeit", "muessen", "jedoch", "folgen", ",", "bevor", "diese", "Therapieform", "generell", "empfohlen", "werden", "kann", "." ]	[ "umlsterm" ]
free radical disturbances and endotoxicosis is a Outcome_Physical, complex antioxidant cytoflavin is a Intervention_Pharmacological, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level is a Outcome_Physical, artificial lung ventilation is a Outcome_Other, staying in critical condition is a Outcome_Other, course of complications is a Outcome_Adverse-effects	53458_task0	Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Outcome_Adverse-effects	[ "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O" ]	[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .	[ "[", "Pharmacological", "correction", "of", "free", "radical", "disturbances", "and", "endotoxicosis", "in", "patients", "with", "diffuse", "peritonitis", "at", "the", "postoperative", "period", "]", ".", "The", "examination", "and", "treatment", "of", "64", "patients", "have", "shown", "that", "inclusion", "of", "complex", "antioxidant", "cytoflavin", "in", "intensive", "therapy", "at", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "allows", "the", "hypoxia", "degree", "to", "be", "decreased", "that", "in", "its", "turn", "results", "in", "quicker", "recovery", "of", "the", "antioxidant", "system", "and", "decreased", "activity", "of", "peroxidation", "and", "endotoxicosis", "level", ".", "The", "clinical", "course", "of", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "with", "cytoflavin", "included", "in", "intensive", "therapy", "is", "characterized", "by", "shorter", "terms", "of", "artificial", "lung", "ventilation", ",", "shorter", "time", "of", "staying", "in", "critical", "condition", ",", "more", "favorable", "course", "of", "complications", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]
free radical disturbances and endotoxicosis is a Outcome_Physical, complex antioxidant cytoflavin is a Intervention_Pharmacological, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level is a Outcome_Physical, artificial lung ventilation is a Outcome_Other, staying in critical condition is a Outcome_Other, course of complications is a Outcome_Adverse-effects	53458_task1	Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please typing these entity words according to sentence: free radical disturbances and endotoxicosis, complex antioxidant cytoflavin, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level, artificial lung ventilation, staying in critical condition, course of complications Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Outcome_Adverse-effects	[ "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O" ]	[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .	[ "[", "Pharmacological", "correction", "of", "free", "radical", "disturbances", "and", "endotoxicosis", "in", "patients", "with", "diffuse", "peritonitis", "at", "the", "postoperative", "period", "]", ".", "The", "examination", "and", "treatment", "of", "64", "patients", "have", "shown", "that", "inclusion", "of", "complex", "antioxidant", "cytoflavin", "in", "intensive", "therapy", "at", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "allows", "the", "hypoxia", "degree", "to", "be", "decreased", "that", "in", "its", "turn", "results", "in", "quicker", "recovery", "of", "the", "antioxidant", "system", "and", "decreased", "activity", "of", "peroxidation", "and", "endotoxicosis", "level", ".", "The", "clinical", "course", "of", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "with", "cytoflavin", "included", "in", "intensive", "therapy", "is", "characterized", "by", "shorter", "terms", "of", "artificial", "lung", "ventilation", ",", "shorter", "time", "of", "staying", "in", "critical", "condition", ",", "more", "favorable", "course", "of", "complications", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]
free radical disturbances and endotoxicosis, complex antioxidant cytoflavin, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level, artificial lung ventilation, staying in critical condition, course of complications	53458_task2	Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O" ]	[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .	[ "[", "Pharmacological", "correction", "of", "free", "radical", "disturbances", "and", "endotoxicosis", "in", "patients", "with", "diffuse", "peritonitis", "at", "the", "postoperative", "period", "]", ".", "The", "examination", "and", "treatment", "of", "64", "patients", "have", "shown", "that", "inclusion", "of", "complex", "antioxidant", "cytoflavin", "in", "intensive", "therapy", "at", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "allows", "the", "hypoxia", "degree", "to", "be", "decreased", "that", "in", "its", "turn", "results", "in", "quicker", "recovery", "of", "the", "antioxidant", "system", "and", "decreased", "activity", "of", "peroxidation", "and", "endotoxicosis", "level", ".", "The", "clinical", "course", "of", "the", "postoperative", "period", "of", "diffuse", "peritonitis", "with", "cytoflavin", "included", "in", "intensive", "therapy", "is", "characterized", "by", "shorter", "terms", "of", "artificial", "lung", "ventilation", ",", "shorter", "time", "of", "staying", "in", "critical", "condition", ",", "more", "favorable", "course", "of", "complications", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]
Audiometrie is an umlsterm, Kindern is an umlsterm, Audiometriekopfhoerer is an umlsterm, Hoerschwellenpegel is an umlsterm, Schalldruckpegel is an umlsterm, Kindern is an umlsterm, Hoerschwellen is an umlsterm, Kindern is an umlsterm, normalhoerender is an umlsterm, Laerm is an umlsterm, Audiometriebereich is an umlsterm, Ohres is an umlsterm	HNO.70450147.ger.abstr_task0	Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .	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Audiometrie is an umlsterm, Kindern is an umlsterm, Audiometriekopfhoerer is an umlsterm, Hoerschwellenpegel is an umlsterm, Schalldruckpegel is an umlsterm, Kindern is an umlsterm, Hoerschwellen is an umlsterm, Kindern is an umlsterm, normalhoerender is an umlsterm, Laerm is an umlsterm, Audiometriebereich is an umlsterm, Ohres is an umlsterm	HNO.70450147.ger.abstr_task1	Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please typing these entity words according to sentence: Audiometrie, Kindern, Audiometriekopfhoerer, Hoerschwellenpegel, Schalldruckpegel, Kindern, Hoerschwellen, Kindern, normalhoerender, Laerm, Audiometriebereich, Ohres Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .	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Audiometrie, Kindern, Audiometriekopfhoerer, Hoerschwellenpegel, Schalldruckpegel, Kindern, Hoerschwellen, Kindern, normalhoerender, Laerm, Audiometriebereich, Ohres	HNO.70450147.ger.abstr_task2	Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .	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REST is a Genes/Proteins	1751_task0	Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes/Proteins	[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The transcription factor REST silences neuronal gene expression in non-neuronal cells.	[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]
REST is a Genes/Proteins	1751_task1	Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please typing these entity words according to sentence: REST Options: Genes/Proteins	[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The transcription factor REST silences neuronal gene expression in non-neuronal cells.	[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]
REST	1751_task2	Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The transcription factor REST silences neuronal gene expression in non-neuronal cells.	[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]
active physical training is a Intervention_Physical, adductor - related groin pain is a Participant_Condition, athletes is a Participant_Condition, active training programme ( AT ) is a Intervention_Physical, physiotherapy treatment without active training ( PT ) is a Intervention_Physical, 68 is a Participant_Sample-size, full return to sports at the same level without groin pain is a Outcome_Pain	93794_task0	Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Pain, Participant_Condition, Participant_Sample-size	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .	[ "Effectiveness", "of", "active", "physical", "training", "as", "treatment", "for", "long", "-", "standing", "adductor", "-", "related", "groin", "pain", "in", "athletes", ":", "randomised", "trial", ".", "BACKGROUND", "Groin", "pain", "is", "common", "among", "athletes", ".", "A", "major", "cause", "of", "long", "-", "standing", "problems", "is", "adductor", "-", "related", "groin", "pain", ".", "The", "purpose", "of", "this", "randomised", "clinical", "trial", "was", "to", "compare", "an", "active", "training", "programme", "(", "AT", ")", "with", "a", "physiotherapy", "treatment", "without", "active", "training", "(", "PT", ")", "in", "the", "treatment", "of", "adductor", "-", "related", "groin", "pain", "in", "athletes", ".", "METHODS", "68", "athletes", "with", "long", "-", "standing", "(", "median", "40", "weeks", ")", "adductor", "-", "related", "groin", "pain", "--", "after", "examination", "according", "to", "a", "standardised", "protocol", "--", "were", "randomly", "assigned", "to", "AT", "or", "PT", ".", "The", "treatment", "period", "was", "8", "-", "12", "weeks", ".", "4", "months", "after", "the", "end", "of", "treatment", "a", "standardised", "examination", "was", "done", ".", "The", "examining", "physician", "was", "unaware", "of", "the", "treatment", "allocation", ".", "The", "ultimate", "outcome", "measure", "was", "full", "return", "to", "sports", "at", "the", "same", "level", "without", "groin", "pain", ".", "Analyses", "were", "by", "intention", "to", "treat", ".", "FINDINGS", "23", "patients", "in", "the", "AT", "group", "and", "four", "in", "the", "PT", "group", "returned", "to", "sports", "without", "groin", "pain", "(", "odds", "ratio", ",", "multiple", "-", "logistic", "-", "regression", "analysis", ",", "12.7", "[", "95", "%", "CI", "3.4", "-", "47.2", "]", ")", ".", "The", "subjective", "global", "assessments", "of", "the", "effect", "of", "the", "treatments", "showed", "a", "significant", "(", "p=0.006", ")", "linear", "trend", "towards", "a", "better", "effect", "in", "the", "AT", "group", ".", "A", "per", "-", "protocol", "analysis", "did", "not", "show", "appreciably", "different", "results", ".", "INTERPRETATION", "AT", "with", "a", "programme", "aimed", "at", "improving", "strength", "and", "coordination", "of", "the", "muscles", "acting", "on", "the", "pelvis", ",", "in", "particular", "the", "adductor", "muscles", ",", "is", "very", "effective", "in", "the", "treatment", "of", "athletes", "with", "long", "-", "standing", "adductor", "-", "related", "groin", "pain", ".", "The", "potential", "preventive", "value", "of", "a", "short", "programme", "based", "upon", "the", "principles", "of", "AT", "should", "be", "assessed", "in", "future", ",", "randomised", ",", "clinical", "trials", "." ]	[ "Outcome_Pain", "Intervention_Physical", "Participant_Condition", "Participant_Sample-size" ]
active physical training is a Intervention_Physical, adductor - related groin pain is a Participant_Condition, athletes is a Participant_Condition, active training programme ( AT ) is a Intervention_Physical, physiotherapy treatment without active training ( PT ) is a Intervention_Physical, 68 is a Participant_Sample-size, full return to sports at the same level without groin pain is a Outcome_Pain	93794_task1	Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please typing these entity words according to sentence: active physical training, adductor - related groin pain, athletes, active training programme ( AT ), physiotherapy treatment without active training ( PT ), 68, full return to sports at the same level without groin pain Options: Intervention_Physical, Outcome_Pain, Participant_Condition, Participant_Sample-size	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .	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active physical training, adductor - related groin pain, athletes, active training programme ( AT ), physiotherapy treatment without active training ( PT ), 68, full return to sports at the same level without groin pain	93794_task2	Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .	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Ala797Thr is a SNP, beta - myosin heavy - chain gene is a Gene, betaMHC is a Gene, Arg92Trp is a SNP, cardiac troponin T gene is a Gene, cTnT is a Gene, Arg645His is a SNP, myosin - binding protein C gene is a Gene, betaMHC is a Gene, Arg403Trp is a SNP, Arg249Gln is a SNP, Gln499Lys is a SNP, betaMHC is a Gene, Val896Met is a SNP, Deltac756 is a SNP, MyBPC - and is a Gene, betaMHC is a Gene, Arg719Gln is a SNP, betaMHC is a Gene, Arg403Trp is a SNP, Ala797Thr is a SNP, Arg92Trp is a SNP, betaMHC is a Gene, Arg92Trp is a SNP	163_task0	Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "B-Gene", "O", "O", "B-SNP", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "B-Gene", "O", "B-SNP", "O", "B-SNP", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "B-Gene", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "B-SNP", "O", "B-SNP", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O" ]	The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.	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Ala797Thr is a SNP, beta - myosin heavy - chain gene is a Gene, betaMHC is a Gene, Arg92Trp is a SNP, cardiac troponin T gene is a Gene, cTnT is a Gene, Arg645His is a SNP, myosin - binding protein C gene is a Gene, betaMHC is a Gene, Arg403Trp is a SNP, Arg249Gln is a SNP, Gln499Lys is a SNP, betaMHC is a Gene, Val896Met is a SNP, Deltac756 is a SNP, MyBPC - and is a Gene, betaMHC is a Gene, Arg719Gln is a SNP, betaMHC is a Gene, Arg403Trp is a SNP, Ala797Thr is a SNP, Arg92Trp is a SNP, betaMHC is a Gene, Arg92Trp is a SNP	163_task1	Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please typing these entity words according to sentence: Ala797Thr, beta - myosin heavy - chain gene, betaMHC, Arg92Trp, cardiac troponin T gene, cTnT, Arg645His, myosin - binding protein C gene, betaMHC, Arg403Trp, Arg249Gln, Gln499Lys, betaMHC, Val896Met, Deltac756, MyBPC - and, betaMHC, Arg719Gln, betaMHC, Arg403Trp, Ala797Thr, Arg92Trp, betaMHC, Arg92Trp Options: Gene, SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "B-Gene", "O", "O", "B-SNP", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "B-Gene", "O", "B-SNP", "O", "B-SNP", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "B-Gene", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "B-SNP", "O", "B-SNP", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O" ]	The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.	[ "The", "origins", "of", "hypertrophic", "cardiomyopathy", "-", "causing", "mutations", "in", "two", "South", "African", "subpopulations", ":", "a", "unique", "profile", "of", "both", "independent", "and", "founder", "events", ".", "Hypertrophic", "cardiomyopathy", "(", "HCM", ")", "is", "an", "autosomal", "dominantly", "inherited", "disease", "of", "the", "cardiac", "sarcomere", ",", "caused", "by", "numerous", "mutations", "in", "genes", "encoding", "protein", "components", "of", "this", "structure", ".", "Mutation", "carriers", "are", "at", "risk", "of", "sudden", "cardiac", "death", ",", "mostly", "as", "adolescents", "or", "young", "adults", ".", "The", "reproductive", "disadvantage", "incurred", "may", "explain", "both", "the", "global", "occurrence", "of", "diverse", "independent", "HCM", "-", "associated", "mutations", "and", "the", "rare", "reports", "of", "founder", "effects", "within", "populations", ".", "We", "have", "investigated", "whether", "this", "holds", "true", "for", "two", "South", "African", "subpopulations", ",", "one", "of", "mixed", "ancestry", "and", "one", "of", "northern", "-", "European", "descent", ".", "Previously", ",", "we", "had", "detected", "three", "novel", "mutations", "-", "Ala797Thr", "in", "the", "beta", "-", "myosin", "heavy", "-", "chain", "gene", "(", "betaMHC", ")", ",", "Arg92Trp", "in", "the", "cardiac", "troponin", "T", "gene", "(", "cTnT", ")", ",", "and", "Arg645His", "in", "the", "myosin", "-", "binding", "protein", "C", "gene", "(", "MyBPC)-and", "two", "documented", "betaMHC", "mutations", "(", "Arg403Trp", "and", "Arg249Gln", ")", ".", "Here", "we", "report", "three", "additional", "novel", "mutations", "-", "Gln499Lys", "in", "betaMHC", "and", "Val896Met", "and", "Deltac756", "in", "MyBPC", "-", "and", "the", "documented", "betaMHC", "Arg719Gln", "mutation", ".", "Seven", "of", "the", "nine", "HCM", "-", "causing", "mutations", "arose", "independently", ";", "no", "conclusions", "can", "be", "drawn", "for", "the", "remaining", "two", ".", "However", ",", "the", "betaMHC", "Arg403Trp", "and", "Ala797Thr", "and", "cTnT", "Arg92Trp", "mutations", "were", "detected", "in", "another", "one", ",", "eight", ",", "and", "four", "probands", ",", "respectively", ",", "and", "haplotype", "analysis", "in", "families", "carrying", "these", "recurring", "mutations", "inferred", "their", "origin", "from", "three", "common", "ancestors", ".", "The", "milder", "phenotype", "of", "the", "betaMHC", "mutations", "may", "account", "for", "the", "presence", "of", "these", "founder", "effects", ",", "whereas", "population", "dynamics", "alone", "may", "have", "overridden", "the", "reproductive", "disadvantage", "incurred", "by", "the", "more", "lethal", ",", "cTnT", "Arg92Trp", "mutation", ".", "\n" ]	[ "Gene", "SNP" ]
Ala797Thr, beta - myosin heavy - chain gene, betaMHC, Arg92Trp, cardiac troponin T gene, cTnT, Arg645His, myosin - binding protein C gene, betaMHC, Arg403Trp, Arg249Gln, Gln499Lys, betaMHC, Val896Met, Deltac756, MyBPC - and, betaMHC, Arg719Gln, betaMHC, Arg403Trp, Ala797Thr, Arg92Trp, betaMHC, Arg92Trp	163_task2	Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "B-Gene", "O", "O", "O", "B-SNP", "O", "O", "B-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "I-Gene", "O", "O", "O", "O", "B-Gene", "O", "O", "B-SNP", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "B-Gene", "O", "B-SNP", "O", "B-SNP", "O", "B-Gene", "I-Gene", "I-Gene", "O", "O", "B-Gene", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "B-SNP", "O", "B-SNP", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O" ]	The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.	[ "The", "origins", "of", "hypertrophic", "cardiomyopathy", "-", "causing", "mutations", "in", "two", "South", "African", "subpopulations", ":", "a", "unique", "profile", "of", "both", "independent", "and", "founder", "events", ".", "Hypertrophic", "cardiomyopathy", "(", "HCM", ")", "is", "an", "autosomal", "dominantly", "inherited", "disease", "of", "the", "cardiac", "sarcomere", ",", "caused", "by", "numerous", "mutations", "in", "genes", "encoding", "protein", "components", "of", "this", "structure", ".", "Mutation", "carriers", "are", "at", "risk", "of", "sudden", "cardiac", "death", ",", "mostly", "as", "adolescents", "or", "young", "adults", ".", "The", "reproductive", "disadvantage", "incurred", "may", "explain", "both", "the", "global", "occurrence", "of", "diverse", "independent", "HCM", "-", "associated", "mutations", "and", "the", "rare", "reports", "of", "founder", "effects", "within", "populations", ".", "We", "have", "investigated", "whether", "this", "holds", "true", "for", "two", "South", "African", "subpopulations", ",", "one", "of", "mixed", "ancestry", "and", "one", "of", "northern", "-", "European", "descent", ".", "Previously", ",", "we", "had", "detected", "three", "novel", "mutations", "-", "Ala797Thr", "in", "the", "beta", "-", "myosin", "heavy", "-", "chain", "gene", "(", "betaMHC", ")", ",", "Arg92Trp", "in", "the", "cardiac", "troponin", "T", "gene", "(", "cTnT", ")", ",", "and", "Arg645His", "in", "the", "myosin", "-", "binding", "protein", "C", "gene", "(", "MyBPC)-and", "two", "documented", "betaMHC", "mutations", "(", "Arg403Trp", "and", "Arg249Gln", ")", ".", "Here", "we", "report", "three", "additional", "novel", "mutations", "-", "Gln499Lys", "in", "betaMHC", "and", "Val896Met", "and", "Deltac756", "in", "MyBPC", "-", "and", "the", "documented", "betaMHC", "Arg719Gln", "mutation", ".", "Seven", "of", "the", "nine", "HCM", "-", "causing", "mutations", "arose", "independently", ";", "no", "conclusions", "can", "be", "drawn", "for", "the", "remaining", "two", ".", "However", ",", "the", "betaMHC", "Arg403Trp", "and", "Ala797Thr", "and", "cTnT", "Arg92Trp", "mutations", "were", "detected", "in", "another", "one", ",", "eight", ",", "and", "four", "probands", ",", "respectively", ",", "and", "haplotype", "analysis", "in", "families", "carrying", "these", "recurring", "mutations", "inferred", "their", "origin", "from", "three", "common", "ancestors", ".", "The", "milder", "phenotype", "of", "the", "betaMHC", "mutations", "may", "account", "for", "the", "presence", "of", "these", "founder", "effects", ",", "whereas", "population", "dynamics", "alone", "may", "have", "overridden", "the", "reproductive", "disadvantage", "incurred", "by", "the", "more", "lethal", ",", "cTnT", "Arg92Trp", "mutation", ".", "\n" ]	[ "Gene", "SNP" ]
ganciclovir is a NORMALIZABLES, corticoides is a NORMALIZABLES, ciclosporina is a NORMALIZABLES, azatioprina is a NORMALIZABLES, Imurel is a NORMALIZABLES	433_task0	Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O" ]	Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).	[ "Paciente", "de", "42", "años", "diagnosticado", "de", "pancolitis", "ulcerosa", "en", "el", "año", "2003", ",", "corticodependiente", ",", "con", "un", "primer", "episodio", "cortirrefractario", "en", "agosto", "de", "2003", "y", "con", "sobreinfección", "por", "citomegalovirus", ",", "que", "se", "trató", "con", "ganciclovir", "iv", ".", "En", "mayo", "de", "2004", ",", "presentó", "un", "brote", "moderado", "con", "diarrea", "con", "sangre", "roja", "(", "2", "deposiciones", "diarias", ")", "y", "desde", "entonces", "anemia", "ferropénica", "crónica", "que", "trata", "con", "ferroterapia", ".", "En", "el", "estudio", "endoscópico", "se", "aprecia", "pancolitis", "ulcerosa", "con", "afectación", "grave", ".", "Recibe", "tratamiento", "con", "corticoides", "e", "inmunosupresores", ".", "\n", "En", "junio", "de", "2007", "presenta", "un", "nuevo", "brote", "de", "actividad", "de", "la", "enfermedad", "con", "10", "-", "12", "deposiciones", "líquidas", "diarias", ",", "dolor", "abdominal", "y", "fiebre", ".", "Debido", "al", "empeoramiento", "clínico", "y", "analítico", "progresivo", "presentado", "por", "el", "paciente", "y", "la", "mala", "respuesta", "al", "tratamiento", "convencional", ",", "se", "decide", "iniciar", "el", "tratamiento", "con", "granulocitoaféresis", "asociado", "a", "ciclosporina", "iv", ".", "\n", "Mientras", "el", "paciente", "estuvo", "ingresado", "se", "realizaron", "4", "sesiones", ",", "siendo", "precisa", "la", "colocación", "de", "un", "catéter", "de", "doble", "luz", "en", "la", "yugular", "derecha", ".", "Hubo", "que", "realizar", "un", "cambio", "de", "catéter", "central", "por", "infección", "MARSA", "se", "realizó", "aislamiento", "de", "contacto).Las", "3", "sesiones", "restantes", "las", "recibió", "de", "forma", "ambulatoria", ".", "Durante", "estos", "meses", ",", "el", "paciente", "ha", "presentado", "una", "mejoría", "clínica", "y", "endoscópica", "de", "evolución", "rápida", ".", "Actualmente", "recibe", "tratamiento", "con", "azatioprina", "(", "Imurel", "®", ")", ".", "\n" ]	[ "NORMALIZABLES" ]
ganciclovir is a NORMALIZABLES, corticoides is a NORMALIZABLES, ciclosporina is a NORMALIZABLES, azatioprina is a NORMALIZABLES, Imurel is a NORMALIZABLES	433_task1	Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please typing these entity words according to sentence: ganciclovir, corticoides, ciclosporina, azatioprina, Imurel Options: NORMALIZABLES	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O" ]	Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).	[ "Paciente", "de", "42", "años", "diagnosticado", "de", "pancolitis", "ulcerosa", "en", "el", "año", "2003", ",", "corticodependiente", ",", "con", "un", "primer", "episodio", "cortirrefractario", "en", "agosto", "de", "2003", "y", "con", "sobreinfección", "por", "citomegalovirus", ",", "que", "se", "trató", "con", "ganciclovir", "iv", ".", "En", "mayo", "de", "2004", ",", "presentó", "un", "brote", "moderado", "con", "diarrea", "con", "sangre", "roja", "(", "2", "deposiciones", "diarias", ")", "y", "desde", "entonces", "anemia", "ferropénica", "crónica", "que", "trata", "con", "ferroterapia", ".", "En", "el", "estudio", "endoscópico", "se", "aprecia", "pancolitis", "ulcerosa", "con", "afectación", "grave", ".", "Recibe", "tratamiento", "con", "corticoides", "e", "inmunosupresores", ".", "\n", "En", "junio", "de", "2007", "presenta", "un", "nuevo", "brote", "de", "actividad", "de", "la", "enfermedad", "con", "10", "-", "12", "deposiciones", "líquidas", "diarias", ",", "dolor", "abdominal", "y", "fiebre", ".", "Debido", "al", "empeoramiento", "clínico", "y", "analítico", "progresivo", "presentado", "por", "el", "paciente", "y", "la", "mala", "respuesta", "al", "tratamiento", "convencional", ",", "se", "decide", "iniciar", "el", "tratamiento", "con", "granulocitoaféresis", "asociado", "a", "ciclosporina", "iv", ".", "\n", "Mientras", "el", "paciente", "estuvo", "ingresado", "se", "realizaron", "4", "sesiones", ",", "siendo", "precisa", "la", "colocación", "de", "un", "catéter", "de", "doble", "luz", "en", "la", "yugular", "derecha", ".", "Hubo", "que", "realizar", "un", "cambio", "de", "catéter", "central", "por", "infección", "MARSA", "se", "realizó", "aislamiento", "de", "contacto).Las", "3", "sesiones", "restantes", "las", "recibió", "de", "forma", "ambulatoria", ".", "Durante", "estos", "meses", ",", "el", "paciente", "ha", "presentado", "una", "mejoría", "clínica", "y", "endoscópica", "de", "evolución", "rápida", ".", "Actualmente", "recibe", "tratamiento", "con", "azatioprina", "(", "Imurel", "®", ")", ".", "\n" ]	[ "NORMALIZABLES" ]
ganciclovir, corticoides, ciclosporina, azatioprina, Imurel	433_task2	Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O" ]	Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).	[ "Paciente", "de", "42", "años", "diagnosticado", "de", "pancolitis", "ulcerosa", "en", "el", "año", "2003", ",", "corticodependiente", ",", "con", "un", "primer", "episodio", "cortirrefractario", "en", "agosto", "de", "2003", "y", "con", "sobreinfección", "por", "citomegalovirus", ",", "que", "se", "trató", "con", "ganciclovir", "iv", ".", "En", "mayo", "de", "2004", ",", "presentó", "un", "brote", "moderado", "con", "diarrea", "con", "sangre", "roja", "(", "2", "deposiciones", "diarias", ")", "y", "desde", "entonces", "anemia", "ferropénica", "crónica", "que", "trata", "con", "ferroterapia", ".", "En", "el", "estudio", "endoscópico", "se", "aprecia", "pancolitis", "ulcerosa", "con", "afectación", "grave", ".", "Recibe", "tratamiento", "con", "corticoides", "e", "inmunosupresores", ".", "\n", "En", "junio", "de", "2007", "presenta", "un", "nuevo", "brote", "de", "actividad", "de", "la", "enfermedad", "con", "10", "-", "12", "deposiciones", "líquidas", "diarias", ",", "dolor", "abdominal", "y", "fiebre", ".", "Debido", "al", "empeoramiento", "clínico", "y", "analítico", "progresivo", "presentado", "por", "el", "paciente", "y", "la", "mala", "respuesta", "al", "tratamiento", "convencional", ",", "se", "decide", "iniciar", "el", "tratamiento", "con", "granulocitoaféresis", "asociado", "a", "ciclosporina", "iv", ".", "\n", "Mientras", "el", "paciente", "estuvo", "ingresado", "se", "realizaron", "4", "sesiones", ",", "siendo", "precisa", "la", "colocación", "de", "un", "catéter", "de", "doble", "luz", "en", "la", "yugular", "derecha", ".", "Hubo", "que", "realizar", "un", "cambio", "de", "catéter", "central", "por", "infección", "MARSA", "se", "realizó", "aislamiento", "de", "contacto).Las", "3", "sesiones", "restantes", "las", "recibió", "de", "forma", "ambulatoria", ".", "Durante", "estos", "meses", ",", "el", "paciente", "ha", "presentado", "una", "mejoría", "clínica", "y", "endoscópica", "de", "evolución", "rápida", ".", "Actualmente", "recibe", "tratamiento", "con", "azatioprina", "(", "Imurel", "®", ")", ".", "\n" ]	[ "NORMALIZABLES" ]
kidney is a Organ, renal is a Organ, kidney is a Organ, renal is a Organ, renal tubular is a Multi-tissue_structure, tubular cell is a Cell, epithelial cells is a Cell, tubules is a Multi-tissue_structure, tubular is a Multi-tissue_structure, interstitial is a Immaterial_anatomical_entity, tubule is a Multi-tissue_structure, tubular is a Multi-tissue_structure, kidney is a Organ, renal tubular epithelial cells is a Cell	PMID-10644902_task0	Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Multi-tissue_structure, Immaterial_anatomical_entity, Organ, Cell	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "B-Immaterial_anatomical_entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.	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kidney is a Organ, renal is a Organ, kidney is a Organ, renal is a Organ, renal tubular is a Multi-tissue_structure, tubular cell is a Cell, epithelial cells is a Cell, tubules is a Multi-tissue_structure, tubular is a Multi-tissue_structure, interstitial is a Immaterial_anatomical_entity, tubule is a Multi-tissue_structure, tubular is a Multi-tissue_structure, kidney is a Organ, renal tubular epithelial cells is a Cell	PMID-10644902_task1	Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please typing these entity words according to sentence: kidney, renal, kidney, renal, renal tubular, tubular cell, epithelial cells, tubules, tubular, interstitial, tubule, tubular, kidney, renal tubular epithelial cells Options: Multi-tissue_structure, Immaterial_anatomical_entity, Organ, Cell	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "B-Immaterial_anatomical_entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.	[ "Obstructive", "nephropathy", ":", "lessons", "from", "cystic", "kidney", "disease", ".", "\n", "Obstructive", "nephropathy", "is", "one", "of", "the", "most", "important", "causes", "of", "renal", "failure", "in", "infants", "and", "children", ",", "while", "polycystic", "kidney", "disease", "(", "PKD", ")", "is", "a", "major", "cause", "of", "renal", "failure", "in", "the", "adult", "population", ".", "This", "review", "summarizes", "the", "evidence", "that", "there", "may", "be", "a", "number", "of", "mechanisms", "common", "to", "the", "pathophysiology", "of", "both", "conditions", ".", "In", "animal", "models", "of", "obstructive", "nephropathy", "and", "PKD", ",", "the", "renal", "tubular", "expression", "of", "epidermal", "growth", "factor", "is", "suppressed", ",", "and", "expression", "of", "clusterin", "is", "increased", ",", "both", "of", "which", "suggest", "arrested", "maturation", "or", "dedifferentiation", "of", "the", "tubular", "cell", ".", "There", "is", "a", "marked", "increase", "in", "apoptosis", "of", "epithelial", "cells", "in", "dilated", "tubules", ",", "associated", "with", "an", "increase", "in", "apoptotic", "stimuli", ".", "The", "renin", "-", "angiotensin", "system", "is", "activated", "in", "both", "obstructive", "nephropathy", "and", "PKD", ",", "which", "may", "contribute", "to", "tubular", "atrophy", "and", "interstitial", "fibrosis", ",", "which", "characterize", "the", "progression", "of", "both", "conditions", ".", "Focal", "cystic", "dilatation", "of", "the", "tubule", "is", "found", "in", "obstructive", "nephropathy", ",", "while", "tubular", "obstruction", "is", "present", "in", "cystic", "kidney", "disease", ".", "It", "is", "therefore", "likely", "that", "elucidation", "of", "the", "effects", "of", "mechanical", "stretch", "on", "renal", "tubular", "epithelial", "cells", "will", "contribute", "to", "our", "understanding", "of", "both", "conditions", ".", "\n" ]	[ "Cell", "Multi-tissue_structure", "Immaterial_anatomical_entity", "Organ" ]
kidney, renal, kidney, renal, renal tubular, tubular cell, epithelial cells, tubules, tubular, interstitial, tubule, tubular, kidney, renal tubular epithelial cells	PMID-10644902_task2	Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "B-Immaterial_anatomical_entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.	[ "Obstructive", "nephropathy", ":", "lessons", "from", "cystic", "kidney", "disease", ".", "\n", "Obstructive", "nephropathy", "is", "one", "of", "the", "most", "important", "causes", "of", "renal", "failure", "in", "infants", "and", "children", ",", "while", "polycystic", "kidney", "disease", "(", "PKD", ")", "is", "a", "major", "cause", "of", "renal", "failure", "in", "the", "adult", "population", ".", "This", "review", "summarizes", "the", "evidence", "that", "there", "may", "be", "a", "number", "of", "mechanisms", "common", "to", "the", "pathophysiology", "of", "both", "conditions", ".", "In", "animal", "models", "of", "obstructive", "nephropathy", "and", "PKD", ",", "the", "renal", "tubular", "expression", "of", "epidermal", "growth", "factor", "is", "suppressed", ",", "and", "expression", "of", "clusterin", "is", "increased", ",", "both", "of", "which", "suggest", "arrested", "maturation", "or", "dedifferentiation", "of", "the", "tubular", "cell", ".", "There", "is", "a", "marked", "increase", "in", "apoptosis", "of", "epithelial", "cells", "in", "dilated", "tubules", ",", "associated", "with", "an", "increase", "in", "apoptotic", "stimuli", ".", "The", "renin", "-", "angiotensin", "system", "is", "activated", "in", "both", "obstructive", "nephropathy", "and", "PKD", ",", "which", "may", "contribute", "to", "tubular", "atrophy", "and", "interstitial", "fibrosis", ",", "which", "characterize", "the", "progression", "of", "both", "conditions", ".", "Focal", "cystic", "dilatation", "of", "the", "tubule", "is", "found", "in", "obstructive", "nephropathy", ",", "while", "tubular", "obstruction", "is", "present", "in", "cystic", "kidney", "disease", ".", "It", "is", "therefore", "likely", "that", "elucidation", "of", "the", "effects", "of", "mechanical", "stretch", "on", "renal", "tubular", "epithelial", "cells", "will", "contribute", "to", "our", "understanding", "of", "both", "conditions", ".", "\n" ]	[ "Cell", "Multi-tissue_structure", "Immaterial_anatomical_entity", "Organ" ]
poly(ethylene carbonate ) is a CHEMICAL	23639738_task0	Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]	Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.	[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]	[ "CHEMICAL", "GENE-Y" ]
poly(ethylene carbonate ) is a CHEMICAL	23639738_task1	Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please typing these entity words according to sentence: poly(ethylene carbonate ) Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]	Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.	[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]	[ "CHEMICAL", "GENE-Y" ]
poly(ethylene carbonate )	23639738_task2	Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]	Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.	[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]	[ "CHEMICAL", "GENE-Y" ]
Augeninnendruck is an umlsterm, Phakoemulsifikation is an umlsterm	DerOpthalmologe.00970331.ger.abstr_task0	Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .	[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]	[ "umlsterm" ]
Augeninnendruck is an umlsterm, Phakoemulsifikation is an umlsterm	DerOpthalmologe.00970331.ger.abstr_task1	Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please typing these entity words according to sentence: Augeninnendruck, Phakoemulsifikation Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .	[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]	[ "umlsterm" ]
Augeninnendruck, Phakoemulsifikation	DerOpthalmologe.00970331.ger.abstr_task2	Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .	[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]	[ "umlsterm" ]
Leukotriene C4 is a compound, IL-8 is a protein, MCP-1 is a protein	DS.d360_task0	Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.	[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]	[ "compound", "protein" ]
Leukotriene C4 is a compound, IL-8 is a protein, MCP-1 is a protein	DS.d360_task1	Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please typing these entity words according to sentence: Leukotriene C4, IL-8, MCP-1 Options: compound, protein	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.	[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]	[ "compound", "protein" ]
Leukotriene C4, IL-8, MCP-1	DS.d360_task2	Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please extract entity words from the input sentence	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.	[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]	[ "compound", "protein" ]
MIP is an umlsterm, diagnostic is an umlsterm, chest is an umlsterm, evaluation is an umlsterm, anatomy is an umlsterm, pathology is an umlsterm	DerRadiologe.90390952.eng.abstr_task0	Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .	[ "Purpose", ":", "To", "test", ",", "whether", "axial", ",", "coronal", "and", "sagittal", "MIP", "and", "MPR", "reconstructions", "of", "diagnostic", "quality", "can", "be", "obtained", "from", "1-mm", "collimation", "MSCT", "data", "of", "the", "chest", "for", "the", "evaluation", "of", "thoracic", "anatomy", "and", "pathology", "." ]	[ "umlsterm" ]
MIP is an umlsterm, diagnostic is an umlsterm, chest is an umlsterm, evaluation is an umlsterm, anatomy is an umlsterm, pathology is an umlsterm	DerRadiologe.90390952.eng.abstr_task1	Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please typing these entity words according to sentence: MIP, diagnostic, chest, evaluation, anatomy, pathology Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .	[ "Purpose", ":", "To", "test", ",", "whether", "axial", ",", "coronal", "and", "sagittal", "MIP", "and", "MPR", "reconstructions", "of", "diagnostic", "quality", "can", "be", "obtained", "from", "1-mm", "collimation", "MSCT", "data", "of", "the", "chest", "for", "the", "evaluation", "of", "thoracic", "anatomy", "and", "pathology", "." ]	[ "umlsterm" ]
MIP, diagnostic, chest, evaluation, anatomy, pathology	DerRadiologe.90390952.eng.abstr_task2	Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .	[ "Purpose", ":", "To", "test", ",", "whether", "axial", ",", "coronal", "and", "sagittal", "MIP", "and", "MPR", "reconstructions", "of", "diagnostic", "quality", "can", "be", "obtained", "from", "1-mm", "collimation", "MSCT", "data", "of", "the", "chest", "for", "the", "evaluation", "of", "thoracic", "anatomy", "and", "pathology", "." ]	[ "umlsterm" ]
galactose is a compound, beta galactosidase is a protein	DS.d373_task0	Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.	[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]	[ "protein", "compound" ]
galactose is a compound, beta galactosidase is a protein	DS.d373_task1	Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please typing these entity words according to sentence: galactose, beta galactosidase Options: compound, protein	[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.	[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]	[ "protein", "compound" ]
galactose, beta galactosidase	DS.d373_task2	Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.	[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]	[ "protein", "compound" ]
TCR repertoire is a protein_family_or_group, Epstein - Barr virus - encoded transactivator protein is a protein_family_or_group, BZLF1 is a protein_molecule, CD8 + cytotoxic T lymphocytes is a cell_type	55581_task0	Sentence: Selection of a diverse TCR repertoire in response to an Epstein-Barr virus-encoded transactivator protein BZLF1 by CD8+ cytotoxic T lymphocytes during primary and persistent infection. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, protein_molecule	[ "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O" ]	Selection of a diverse TCR repertoire in response to an Epstein-Barr virus-encoded transactivator protein BZLF1 by CD8+ cytotoxic T lymphocytes during primary and persistent infection.	[ "Selection", "of", "a", "diverse", "TCR", "repertoire", "in", "response", "to", "an", "Epstein", "-", "Barr", "virus", "-", "encoded", "transactivator", "protein", "BZLF1", "by", "CD8", "+", "cytotoxic", "T", "lymphocytes", "during", "primary", "and", "persistent", "infection", "." ]	[ "cell_line", "protein_family_or_group", "multi_cell", "cell_type", "(AND virus virus)", "other_name", "(OR other_name other_name)", "peptide", "(AND cell_line cell_line)", "virus", "protein_domain_or_region", "RNA_molecule", "", "protein_subunit", "DNA_domain_or_region", "protein_molecule" ]

psychotic is an umlsterm, patients is an umlsterm, hyperglycaemia is an umlsterm, olanzapine is an umlsterm, elevated glucose is an umlsterm, concentrations is an umlsterm, olanzapine is an umlsterm

DerNervenarzt.90700836.eng.abstr_task0

Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .

[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]

[ "umlsterm" ]

psychotic is an umlsterm, patients is an umlsterm, hyperglycaemia is an umlsterm, olanzapine is an umlsterm, elevated glucose is an umlsterm, concentrations is an umlsterm, olanzapine is an umlsterm

DerNervenarzt.90700836.eng.abstr_task1

Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please typing these entity words according to sentence: psychotic, patients, hyperglycaemia, olanzapine, elevated glucose, concentrations, olanzapine Options: umlsterm

[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .

[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]

[ "umlsterm" ]

psychotic, patients, hyperglycaemia, olanzapine, elevated glucose, concentrations, olanzapine

DerNervenarzt.90700836.eng.abstr_task2

Sentence: Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine . In one case the elevated glucose concentrations returned to normal soon after withdrawal of olanzapine . In the second case severe ketoacidosis with letal outcome occured .

[ "Two", "psychotic", "patients", "developed", "hyperglycaemia", "several", "weeks", "after", "starting", "olanzapine", ".", "In", "one", "case", "the", "elevated", "glucose", "concentrations", "returned", "to", "normal", "soon", "after", "withdrawal", "of", "olanzapine", ".", "In", "the", "second", "case", "severe", "ketoacidosis", "with", "letal", "outcome", "occured", "." ]

[ "umlsterm" ]

nuclear factor - kappaB is a Entity, cytokine genes is a Entity, interleukin-1beta is a Protein, interleukin-1beta is a Protein, inhibitor - kappaB alpha is a Protein, DNA is a Entity, nuclear factor - kappaB is a Entity, nuclear factor - kappaB is a Entity, interleukin-1beta is a Protein

103_task0

Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

[ "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O" ]

Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.

[ "Activation", "of", "nuclear", "factor", "-", "kappaB", "by", "lipopolysaccharide", "in", "mononuclear", "leukocytes", "is", "prevented", "by", "inhibitors", "of", "cytosolic", "phospholipase", "A2", ".", "\n", "In", "monocytes", ",", "lipopolysaccharide", "induces", "synthesis", "and", "activity", "of", "the", "85-kDa", "cytosolic", "phospholipase", "A2", ".", "This", "enzyme", "releases", "arachidonic", "acid", "and", "lyso", "-", "phospholipids", "from", "membranes", "which", "are", "metabolized", "to", "eicosanoids", "and", "platelet", "-", "activating", "-", "factor", ".", "These", "lipid", "mediators", "increase", "activity", "of", "transcription", "factors", "and", "expression", "of", "cytokine", "genes", "indicating", "a", "function", "for", "cytosolic", "phospholipase", "A2", "in", "signal", "transduction", "and", "inflammation", ".", "We", "have", "shown", "previously", "that", "trifluoromethylketone", "inhibitors", "of", "cytosolic", "phospholipase", "A2", "suppressed", "interleukin-1beta", "protein", "and", "steady", "-", "state", "mRNA", "levels", "in", "human", "lipopolysaccharide", "-", "stimulated", "peripheral", "blood", "mononuclear", "leukocytes", ".", "In", "this", "study", ",", "the", "subcellular", "mechanisms", "were", "analyzed", "by", "which", "trifluoromethylketones", "interfere", "with", "gene", "expression", ".", "We", "found", "that", "they", "reduced", "the", "initial", "interleukin-1beta", "mRNA", "transcription", "rate", "through", "prevention", "of", "degradation", "of", "inhibitor", "-", "kappaB", "alpha", ".", "Consequently", ",", "cytosolic", "activation", ",", "nuclear", "translocation", "and", "DNA", "-", "binding", "of", "nuclear", "factor", "-", "kappaB", "were", "decreased", ".", "Trifluoromethylketones", "ameliorate", "chronic", "inflammation", "in", "vivo", ".", "Thus", ",", "this", "therapeutic", "potency", "may", "reside", "in", "retention", "of", "inactive", "nuclear", "factor", "-", "kappaB", "in", "the", "cytosol", "thereby", "abrogating", "interleukin-1beta", "gene", "transcription", ".", "\n" ]

[ "Protein", "Entity" ]

nuclear factor - kappaB is a Entity, cytokine genes is a Entity, interleukin-1beta is a Protein, interleukin-1beta is a Protein, inhibitor - kappaB alpha is a Protein, DNA is a Entity, nuclear factor - kappaB is a Entity, nuclear factor - kappaB is a Entity, interleukin-1beta is a Protein

103_task1

Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please typing these entity words according to sentence: nuclear factor - kappaB, cytokine genes, interleukin-1beta, interleukin-1beta, inhibitor - kappaB alpha, DNA, nuclear factor - kappaB, nuclear factor - kappaB, interleukin-1beta Options: Entity, Protein

[ "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O" ]

Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.

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[ "Protein", "Entity" ]

nuclear factor - kappaB, cytokine genes, interleukin-1beta, interleukin-1beta, inhibitor - kappaB alpha, DNA, nuclear factor - kappaB, nuclear factor - kappaB, interleukin-1beta

103_task2

Sentence: Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription. Instructions: please extract entity words from the input sentence

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Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2. This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor. These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation. We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes. In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression. We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha. Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased. Trifluoromethylketones ameliorate chronic inflammation in vivo. Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.

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[ "Protein", "Entity" ]

Vorhofflimmern is an umlsterm, Personen is an umlsterm, Herzrhythmusstoerung is an umlsterm, Therapie is an umlsterm, Antikoagulantien is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm, Antiarrhythmika is an umlsterm, medikamentoesen Therapie is an umlsterm, Katheterablation is an umlsterm, Therapie is an umlsterm, Katheterablation is an umlsterm, Leitungseigenschaften is an umlsterm, AV - Knoten is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Technik is an umlsterm, Effizienz is an umlsterm, Technik is an umlsterm, Herzkammer is an umlsterm

Herzschrittmachertherapie.8009s031.ger.abstr_task0

Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .

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Vorhofflimmern is an umlsterm, Personen is an umlsterm, Herzrhythmusstoerung is an umlsterm, Therapie is an umlsterm, Antikoagulantien is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm, Antiarrhythmika is an umlsterm, medikamentoesen Therapie is an umlsterm, Katheterablation is an umlsterm, Therapie is an umlsterm, Katheterablation is an umlsterm, Leitungseigenschaften is an umlsterm, AV - Knoten is an umlsterm, Methoden is an umlsterm, Therapie is an umlsterm, Technik is an umlsterm, Effizienz is an umlsterm, Technik is an umlsterm, Herzkammer is an umlsterm

Herzschrittmachertherapie.8009s031.ger.abstr_task1

Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please typing these entity words according to sentence: Vorhofflimmern, Personen, Herzrhythmusstoerung, Therapie, Antikoagulantien, Morbiditaet, Mortalitaet, Patienten, Antiarrhythmika, medikamentoesen Therapie, Katheterablation, Therapie, Katheterablation, Leitungseigenschaften, AV - Knoten, Methoden, Therapie, Technik, Effizienz, Technik, Herzkammer Options: umlsterm

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Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .

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[ "umlsterm" ]

Vorhofflimmern, Personen, Herzrhythmusstoerung, Therapie, Antikoagulantien, Morbiditaet, Mortalitaet, Patienten, Antiarrhythmika, medikamentoesen Therapie, Katheterablation, Therapie, Katheterablation, Leitungseigenschaften, AV - Knoten, Methoden, Therapie, Technik, Effizienz, Technik, Herzkammer

Herzschrittmachertherapie.8009s031.ger.abstr_task2

Sentence: Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt . Instructions: please extract entity words from the input sentence

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Vorhofflimmern ist mit einer Haeufigkeit von 2-4% aller Personen aelter als 60 Jahre die am weitesten verbreitete Herzrhythmusstoerung . Die Therapie mit Antikoagulantien fuehrt zu einer deutlichen Reduktion der Morbiditaet und Mortalitaet bei diesen Patienten . Die Symptome sind sehr vielfaeltig ; die Reaktionen auf die Antiarrhythmika nicht vorhersehbar . Alternative Behandlungsmoeglichkeiten zur medikamentoesen Therapie sind die Katheterablation mittels Hochfrequenzstrom , der implantierbare Vorhofdefibrillator und die " Maze " -Operation . Der Einsatz des Vorhofdefibrillators wird derzeit untersucht , obwohl seine klinische Anwendbarkeit fragwuerdig ist . Die Maze " " -Operation hat sich als eine effektive kurative Therapie des permanenten und paroxymalen Vorhofflimmerns erwiesen . Allerdings ist dieses Verfahren nur bei ausgewaehlten Faellen indiziert und sollte nur in speziellen Zentren durchgefuehrt werden . Die Ziele der Katheterablation sind zweifach : 1 ) die Herabsetzung und Regulierung der Kammerfrequenz und 2 ) die primaere Beseitigung des anatomisch-elektrophysiologischen Substrates des Vorhofflimmerns . Der zuerst genannte Aspekt wird durch eine Modifikation der Leitungseigenschaften oder durch Ablation des AV-Knoten mit Implantation eines Schrittmachers erreicht . Bei beiden Methoden wurde von einer klinischen Verbesserung von 80% berichtet . Ein vielversprechendes Verfahren zur kurativen Therapie des Vorhofflimmerns stellt die Maze " " -Operation im Katheterlabor dar . Erste Ergebnisse zeigen , dass die Technik anwendbar ist , obwohl die Effizienz verbessert werden muss . Eine moegliche Anwendung dieser Technik wird erleichtert durch die kuerzlich eingefuehrte computergestuetzte Mapping-Technik , die eine dreidimensional elektroanatomische Rekonstruktion der Herzkammer erlaubt .

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[ "umlsterm" ]

CYP3A4 is a GENE-Y, CYP3A4 is a GENE-Y, P - glycoprotein is a GENE-N, Pgp is a GENE-N, Multidrug Resistance Associated Protein 2 is a GENE-Y, MRP-2 is a GENE-Y, Breast Cancer Resistance Protein is a GENE-Y, BCRP is a GENE-Y, MonoCarboxylate Transporter 1 is a GENE-Y, MCT1 is a GENE-Y, Organic Anion Transporting Polypeptide is a GENE-N, OATP is a GENE-N, Peptide transporter 1 is a GENE-Y, PepT1 is a GENE-Y, human immunodeficiency virus protease is a GENE-N, saquinavir is a CHEMICAL, ritonavir is a CHEMICAL, darunavir is a CHEMICAL, P - glycoprotein is a GENE-N, CYP3A4 is a GENE-Y

26575_task0

Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL, GENE-Y, GENE-N

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The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

CYP3A4 is a GENE-Y, CYP3A4 is a GENE-Y, P - glycoprotein is a GENE-N, Pgp is a GENE-N, Multidrug Resistance Associated Protein 2 is a GENE-Y, MRP-2 is a GENE-Y, Breast Cancer Resistance Protein is a GENE-Y, BCRP is a GENE-Y, MonoCarboxylate Transporter 1 is a GENE-Y, MCT1 is a GENE-Y, Organic Anion Transporting Polypeptide is a GENE-N, OATP is a GENE-N, Peptide transporter 1 is a GENE-Y, PepT1 is a GENE-Y, human immunodeficiency virus protease is a GENE-N, saquinavir is a CHEMICAL, ritonavir is a CHEMICAL, darunavir is a CHEMICAL, P - glycoprotein is a GENE-N, CYP3A4 is a GENE-Y

26575_task1

Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please typing these entity words according to sentence: CYP3A4, CYP3A4, P - glycoprotein, Pgp, Multidrug Resistance Associated Protein 2, MRP-2, Breast Cancer Resistance Protein, BCRP, MonoCarboxylate Transporter 1, MCT1, Organic Anion Transporting Polypeptide, OATP, Peptide transporter 1, PepT1, human immunodeficiency virus protease, saquinavir, ritonavir, darunavir, P - glycoprotein, CYP3A4 Options: CHEMICAL, GENE-Y, GENE-N

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The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

CYP3A4, CYP3A4, P - glycoprotein, Pgp, Multidrug Resistance Associated Protein 2, MRP-2, Breast Cancer Resistance Protein, BCRP, MonoCarboxylate Transporter 1, MCT1, Organic Anion Transporting Polypeptide, OATP, Peptide transporter 1, PepT1, human immunodeficiency virus protease, saquinavir, ritonavir, darunavir, P - glycoprotein, CYP3A4

26575_task2

Sentence: The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities. Instructions: please extract entity words from the input sentence

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The mechanisms responsible for garlic - drug interactions and their in vivo relevance. Garlic phytochemicals and garlic supplements influence the pharmacokinetic and pharmacodynamic behavior of concomitantly ingested drugs. In this paper we have summarized the mechanisms responsible for first-pass intestinal pharmacokinetic interactions by investigating the intestinal permeability of some cardiovascular, antiviral drugs, their transport with hepatic transporters and CYP3A4 metabolism. Transporter-enzyme interplay was studied with several in vitro models of varying complexity: rat small intestine and Caco-2 cell monolayers were used in studies of intestinal processes, and hepatic pharmacokinetics was monitored in HepG2 cells, isolated rat hepatocytes and rat liver slices. Garlic phytochemicals from aged garlic extract modified the activities of secretory and absorptive transporters in both intestine and liver and competitively inhibited CYP3A4 enzyme. The increased activities of the most important intestinal efflux (P-glycoprotein - Pgp, Multidrug Resistance Associated Protein 2 - MRP-2, Breast Cancer Resistance Protein - BCRP) and uptake (MonoCarboxylate Transporter 1 - MCT1, Organic Anion Transporting Polypeptide - OATP, Peptide transporter 1 - PepT1) transporters were caused by changes in electrophysiological membrane properties and by allosteric modifications. Because clinical studies investigating interactions between garlic and human immunodeficiency virus protease inhibitors saquinavir and ritonavir have already been performed, we used these in vivo data to evaluate the in vitro results and the reliability of the models employed as screening tools for forecasting the potential of first-pass intestinal metabolism changes. We also assessed the probability of pharmacokinetic interactions with garlic of the novel drug darunavir and other cardiovascular drugs. Finally, selected garlic phytochemicals were tested for their ability to influence P-glycoprotein and CYP3A4 activities.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Caucasian is a Person, male is a Person, female is a Person, At least 18 years is a Value, age is a Person, Weight is a Measurement, at least 45 kg is a Value, moderate or severe is a Scope, chronic atopic dermatitis is a Condition, Good general health is a Condition, ascertained by medical history , physical examination and laboratory determinations is a Qualifier, no is a Negation, signs of clinically significant findings is a Observation, except is a Negation, chronic atopic dermatitis is a Condition, Negative is a Value, pregnancy test is a Measurement, premenopausal female is a Scope

NCT01320579_inc_task0

Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Observation, Negation, Scope, Measurement

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Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose

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[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]

Caucasian is a Person, male is a Person, female is a Person, At least 18 years is a Value, age is a Person, Weight is a Measurement, at least 45 kg is a Value, moderate or severe is a Scope, chronic atopic dermatitis is a Condition, Good general health is a Condition, ascertained by medical history , physical examination and laboratory determinations is a Qualifier, no is a Negation, signs of clinically significant findings is a Observation, except is a Negation, chronic atopic dermatitis is a Condition, Negative is a Value, pregnancy test is a Measurement, premenopausal female is a Scope

NCT01320579_inc_task1

Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please typing these entity words according to sentence: Caucasian, male, female, At least 18 years, age, Weight, at least 45 kg, moderate or severe, chronic atopic dermatitis, Good general health, ascertained by medical history , physical examination and laboratory determinations, no, signs of clinically significant findings, except, chronic atopic dermatitis, Negative, pregnancy test, premenopausal female Options: Condition, Qualifier, Value, Person, Observation, Negation, Scope, Measurement

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Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose

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[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]

Caucasian, male, female, At least 18 years, age, Weight, at least 45 kg, moderate or severe, chronic atopic dermatitis, Good general health, ascertained by medical history , physical examination and laboratory determinations, no, signs of clinically significant findings, except, chronic atopic dermatitis, Negative, pregnancy test, premenopausal female

NCT01320579_inc_task2

Sentence: Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose Instructions: please extract entity words from the input sentence

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Informed consent obtained prior to any screening procedure Caucasian male or female patient At least 18 years of age Weight at least 45 kg Patient with moderate or severe chronic atopic dermatitis Good general health ascertained by medical history, physical examination and laboratory determinations, showing no signs of clinically significant findings, except chronic atopic dermatitis Negative pregnancy test (premenopausal female patient) at screening and use of adequate contraceptive measures (both male and female patients) throughout the study and 30 days after the last cis-UCA dose

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[ "Qualifier", "Observation", "Condition", "Procedure", "Scope", "Value", "Measurement", "Person", "Negation" ]

Glucocorticoid - resistance is an other_name, peripheral - blood lymphocytes is a cell_type, glucocorticoid - receptors is a protein_family_or_group, chronic renal failure is an other_name, patients is a multi_cell

65313_task0

Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, multi_cell, other_name

[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]

Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.

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[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]

Glucocorticoid - resistance is an other_name, peripheral - blood lymphocytes is a cell_type, glucocorticoid - receptors is a protein_family_or_group, chronic renal failure is an other_name, patients is a multi_cell

65313_task1

Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please typing these entity words according to sentence: Glucocorticoid - resistance, peripheral - blood lymphocytes, glucocorticoid - receptors, chronic renal failure, patients Options: cell_type, protein_family_or_group, multi_cell, other_name

[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]

Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.

[ "Glucocorticoid", "-", "resistance", "in", "peripheral", "-", "blood", "lymphocytes", "does", "not", "correlate", "with", "number", "of", "affinity", "of", "glucocorticoid", "-", "receptors", "in", "chronic", "renal", "failure", "patients", "." ]

[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]

Glucocorticoid - resistance, peripheral - blood lymphocytes, glucocorticoid - receptors, chronic renal failure, patients

65313_task2

Sentence: Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients. Instructions: please extract entity words from the input sentence

[ "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "B-multi_cell", "O" ]

Glucocorticoid-resistance in peripheral-blood lymphocytes does not correlate with number of affinity of glucocorticoid-receptors in chronic renal failure patients.

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[ "cell_type", "other_name", "protein_family_or_group", "multi_cell", "lipid", "other_organic_compound" ]

association is an umlsterm, nevus flammeus is an umlsterm, mongolian is an umlsterm, spot is an umlsterm, nevus is an umlsterm, nevus is an umlsterm, frequency is an umlsterm, nevus is an umlsterm, phacomatosis is an umlsterm, co - workers is an umlsterm, literature is an umlsterm, Phacomatosis is an umlsterm, disorder is an umlsterm, syndromes is an umlsterm, Klippel - Trenaunay syndrome is an umlsterm, Sturge - Weber syndrome is an umlsterm, woman is an umlsterm, nevus flammeus is an umlsterm, back is an umlsterm, right is an umlsterm, arm is an umlsterm, nevus is an umlsterm, back is an umlsterm

DerHautarzt.70480653.eng.abstr_task0

Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .

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[ "umlsterm" ]

association is an umlsterm, nevus flammeus is an umlsterm, mongolian is an umlsterm, spot is an umlsterm, nevus is an umlsterm, nevus is an umlsterm, frequency is an umlsterm, nevus is an umlsterm, phacomatosis is an umlsterm, co - workers is an umlsterm, literature is an umlsterm, Phacomatosis is an umlsterm, disorder is an umlsterm, syndromes is an umlsterm, Klippel - Trenaunay syndrome is an umlsterm, Sturge - Weber syndrome is an umlsterm, woman is an umlsterm, nevus flammeus is an umlsterm, back is an umlsterm, right is an umlsterm, arm is an umlsterm, nevus is an umlsterm, back is an umlsterm

DerHautarzt.70480653.eng.abstr_task1

Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please typing these entity words according to sentence: association, nevus flammeus, mongolian, spot, nevus, nevus, frequency, nevus, phacomatosis, co - workers, literature, Phacomatosis, disorder, syndromes, Klippel - Trenaunay syndrome, Sturge - Weber syndrome, woman, nevus flammeus, back, right, arm, nevus, back Options: umlsterm

[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .

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[ "umlsterm" ]

association, nevus flammeus, mongolian, spot, nevus, nevus, frequency, nevus, phacomatosis, co - workers, literature, Phacomatosis, disorder, syndromes, Klippel - Trenaunay syndrome, Sturge - Weber syndrome, woman, nevus flammeus, back, right, arm, nevus, back

DerHautarzt.70480653.eng.abstr_task2

Sentence: The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

The association of nevus flammeus with mongolian spot , nevus fuscoceruleus , nevus spilus and , with variable frequency , with nevus anemicus has been termed phacomatosis pigmentovascularis , a genodermatosis first described by Ota and co-workers . Four different combinations have been specified . Most cases are reported from the Japanese literature . Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder , but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible . We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back .

[ "The", "association", "of", "nevus", "flammeus", "with", "mongolian", "spot", ",", "nevus", "fuscoceruleus", ",", "nevus", "spilus", "and", ",", "with", "variable", "frequency", ",", "with", "nevus", "anemicus", "has", "been", "termed", "phacomatosis", "pigmentovascularis", ",", "a", "genodermatosis", "first", "described", "by", "Ota", "and", "co", "-", "workers", ".", "Four", "different", "combinations", "have", "been", "specified", ".", "Most", "cases", "are", "reported", "from", "the", "Japanese", "literature", ".", "Phacomatosis", "pigmentovascularis", "may", "constitute", "an", "exclusively", "cutaneous", "disorder", ",", "but", "overlapping", "with", "other", "syndromes", "like", "Klippel", "-", "Trenaunay", "syndrome", "or", "Sturge", "-", "Weber", "syndrome", "is", "also", "possible", ".", "We", "report", "a", "30-year", "-", "old", "woman", "with", "nevus", "flammeus", "on", "the", "back", "and", "right", "arm", "associated", "with", "nevus", "fuscoceruleus", "on", "the", "back", "." ]

[ "umlsterm" ]

psychosexual development is an umlsterm, genitalia is an umlsterm, constitution is an umlsterm, female is an umlsterm, development is an umlsterm, light is an umlsterm, classification is an umlsterm, sexual dysfunctions is an umlsterm, men is an umlsterm, women is an umlsterm, sexual dysfunctions is an umlsterm, sexuality is an umlsterm, sexual dysfunction is an umlsterm, psychoanalysis is an umlsterm, symptoms is an umlsterm, conflicts is an umlsterm

Psychotherapeut.90440279.eng.abstr_task0

Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .

[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]

[ "umlsterm" ]

psychosexual development is an umlsterm, genitalia is an umlsterm, constitution is an umlsterm, female is an umlsterm, development is an umlsterm, light is an umlsterm, classification is an umlsterm, sexual dysfunctions is an umlsterm, men is an umlsterm, women is an umlsterm, sexual dysfunctions is an umlsterm, sexuality is an umlsterm, sexual dysfunction is an umlsterm, psychoanalysis is an umlsterm, symptoms is an umlsterm, conflicts is an umlsterm

Psychotherapeut.90440279.eng.abstr_task1

Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please typing these entity words according to sentence: psychosexual development, genitalia, constitution, female, development, light, classification, sexual dysfunctions, men, women, sexual dysfunctions, sexuality, sexual dysfunction, psychoanalysis, symptoms, conflicts Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .

[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]

[ "umlsterm" ]

psychosexual development, genitalia, constitution, female, development, light, classification, sexual dysfunctions, men, women, sexual dysfunctions, sexuality, sexual dysfunction, psychoanalysis, symptoms, conflicts

Psychotherapeut.90440279.eng.abstr_task2

Sentence: Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Aspects of the infantile psychosexual development are described concerning the discovering of the genitalia , the constitution of the body-image and the gender-role . Freud's theory of female sexual development is reviewed in the light of modern theories of femininity . A classification of sexual dysfunctions is presented . The psychodynamics of men and women with sexual dysfunctions and Kernbergs theory of sexuality in partnership are described . Finally the lack of interest in sexual dysfunction in psychoanalysis is delineated and the importance of treating sexual symptoms while considering underlying conflicts is pointed out .

[ "Aspects", "of", "the", "infantile", "psychosexual", "development", "are", "described", "concerning", "the", "discovering", "of", "the", "genitalia", ",", "the", "constitution", "of", "the", "body", "-", "image", "and", "the", "gender", "-", "role", ".", "Freud", "'s", "theory", "of", "female", "sexual", "development", "is", "reviewed", "in", "the", "light", "of", "modern", "theories", "of", "femininity", ".", "A", "classification", "of", "sexual", "dysfunctions", "is", "presented", ".", "The", "psychodynamics", "of", "men", "and", "women", "with", "sexual", "dysfunctions", "and", "Kernbergs", "theory", "of", "sexuality", "in", "partnership", "are", "described", ".", "Finally", "the", "lack", "of", "interest", "in", "sexual", "dysfunction", "in", "psychoanalysis", "is", "delineated", "and", "the", "importance", "of", "treating", "sexual", "symptoms", "while", "considering", "underlying", "conflicts", "is", "pointed", "out", "." ]

[ "umlsterm" ]

intraoperative complication is an umlsterm, cholecystectomy is an umlsterm, gallbladder is an umlsterm, gallstones is an umlsterm, woman is an umlsterm, tumor is an umlsterm, abscess is an umlsterm, gallstones is an umlsterm, cholecystectomy is an umlsterm, incidence is an umlsterm, abscesses is an umlsterm, gallstones is an umlsterm, symptoms is an umlsterm, diagnosis is an umlsterm, complications is an umlsterm, gallstones is an umlsterm, open is an umlsterm, procedure is an umlsterm

DerChirurg.60671047.eng.abstr_task0

Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .

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[ "umlsterm" ]

intraoperative complication is an umlsterm, cholecystectomy is an umlsterm, gallbladder is an umlsterm, gallstones is an umlsterm, woman is an umlsterm, tumor is an umlsterm, abscess is an umlsterm, gallstones is an umlsterm, cholecystectomy is an umlsterm, incidence is an umlsterm, abscesses is an umlsterm, gallstones is an umlsterm, symptoms is an umlsterm, diagnosis is an umlsterm, complications is an umlsterm, gallstones is an umlsterm, open is an umlsterm, procedure is an umlsterm

DerChirurg.60671047.eng.abstr_task1

Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please typing these entity words according to sentence: intraoperative complication, cholecystectomy, gallbladder, gallstones, woman, tumor, abscess, gallstones, cholecystectomy, incidence, abscesses, gallstones, symptoms, diagnosis, complications, gallstones, open, procedure Options: umlsterm

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A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .

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[ "umlsterm" ]

intraoperative complication, cholecystectomy, gallbladder, gallstones, woman, tumor, abscess, gallstones, cholecystectomy, incidence, abscesses, gallstones, symptoms, diagnosis, complications, gallstones, open, procedure

DerChirurg.60671047.eng.abstr_task2

Sentence: A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure . Instructions: please extract entity words from the input sentence

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A possible intraoperative complication of laparoscopic cholecystectomy is opening of the gallbladder with subsequent loss of gallstones . We report on a 61-year-old woman who was hospitalised with an obscure subhepatic tumor . Intraoperatively an abscess was found that had been caused by lost gallstones following after laparoscopic cholecystectomy 3 years previously . There is a low incidence of late abscesses caused by loss of gallstones , but because of the long latency and unspecific symptoms there may be problems in diagnosis . Taking into consideration possible complications caused by intraoperative loss of gallstones , all concrements should be retrieved , even though there is no indication for changing to an open procedure .

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[ "umlsterm" ]

Raquel is a NOMBRE_SUJETO_ASISTENCIA, Cuenca Suarez is a NOMBRE_SUJETO_ASISTENCIA, 2783962 is a ID_SUJETO_ASISTENCIA, 28 89034672 35 is a ID_ASEGURAMIENTO, C/ Virgen del Cortijo,94 is a CALLE, Sevilla is a TERRITORIO, 41013 is a TERRITORIO, 08/03/19 is a FECHAS, España is a PAIS, 39 años is a EDAD_SUJETO_ASISTENCIA, 21/09/2012 is a FECHAS, 7435075 is a ID_CONTACTO_ASISTENCIAL, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, 41 41 57896 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 39 años is a EDAD_SUJETO_ASISTENCIA, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, Hospital Universitario Virgen del Rocío is a HOSPITAL, Avda . Manuel Siurot , s / n is a CALLE, 41013 is a TERRITORIO, Sevilla is a TERRITORIO, 955 012 000 is a NUMERO_TELEFONO, raqgores@yahoo.es is a CORREO_ELECTRONICO

85_task0

Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, NUMERO_TELEFONO, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es

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Raquel is a NOMBRE_SUJETO_ASISTENCIA, Cuenca Suarez is a NOMBRE_SUJETO_ASISTENCIA, 2783962 is a ID_SUJETO_ASISTENCIA, 28 89034672 35 is a ID_ASEGURAMIENTO, C/ Virgen del Cortijo,94 is a CALLE, Sevilla is a TERRITORIO, 41013 is a TERRITORIO, 08/03/19 is a FECHAS, España is a PAIS, 39 años is a EDAD_SUJETO_ASISTENCIA, 21/09/2012 is a FECHAS, 7435075 is a ID_CONTACTO_ASISTENCIAL, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, 41 41 57896 is a ID_TITULACION_PERSONAL_SANITARIO, Mujer is a SEXO_SUJETO_ASISTENCIA, 39 años is a EDAD_SUJETO_ASISTENCIA, Raquel González Resina is a NOMBRE_PERSONAL_SANITARIO, Hospital Universitario Virgen del Rocío is a HOSPITAL, Avda . Manuel Siurot , s / n is a CALLE, 41013 is a TERRITORIO, Sevilla is a TERRITORIO, 955 012 000 is a NUMERO_TELEFONO, raqgores@yahoo.es is a CORREO_ELECTRONICO

85_task1

Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es Instructions: please typing these entity words according to sentence: Raquel, Cuenca Suarez, 2783962, 28 89034672 35, C/ Virgen del Cortijo,94, Sevilla, 41013, 08/03/19, España, 39 años, 21/09/2012, 7435075, Raquel González Resina, 41 41 57896, Mujer, 39 años, Raquel González Resina, Hospital Universitario Virgen del Rocío, Avda . Manuel Siurot , s / n, 41013, Sevilla, 955 012 000, raqgores@yahoo.es Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, NUMERO_TELEFONO, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es

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Raquel, Cuenca Suarez, 2783962, 28 89034672 35, C/ Virgen del Cortijo,94, Sevilla, 41013, 08/03/19, España, 39 años, 21/09/2012, 7435075, Raquel González Resina, 41 41 57896, Mujer, 39 años, Raquel González Resina, Hospital Universitario Virgen del Rocío, Avda . Manuel Siurot , s / n, 41013, Sevilla, 955 012 000, raqgores@yahoo.es

85_task2

Sentence: Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es Instructions: please extract entity words from the input sentence

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Datos del paciente. Nombre: Raquel. Apellidos: Cuenca Suarez. NHC: 2783962. NASS: 28 89034672 35. Domicilio: C/ Virgen del Cortijo,94 . Localidad/ Provincia: Sevilla. CP: 41013. Datos asistenciales. Fecha de nacimiento: 08/03/19. País de nacimiento: España. Edad: 39 años Sexo: M. Fecha de Ingreso: 21/09/2012. Servicio: Urgencias. Episodio: 7435075. Médico: Raquel González Resina NºCol: 41 41 57896. Historia Actual:Mujer de 39 años acude a urgencias por lumbalgia y polaquiuria. En la ecografía abdominal realizada se objetivó una ureterohidronefrosis bilateral con parénquima renal izquierdo conservado y riñón derecho de cortical fina y desestructurada, así como una función renal con una creatinina sérica de 1,98 mg/dl. Por todo ello, se decide una derivación urinaria mediante nefrostomía percutánea del riñón izquierdo. Como antecedentes personales refiere tuberculosis pulmonar, cólicos nefríticos de repetición e incontinencia urinaria de esfuerzo. Se diagnostica de tuberculosis genitourinaria por cultivo de Lowestein positivo en la orina evacuada por la nefrostomía y se instaura tratamiento médico, con Rifampicina, Isoniacida y Pirazinamida durante 2 meses e Isoniacida y Rifampicina 4 meses más. Durante el seguimiento en consultas externas, se realiza una gammagrafía renal en la que se aprecia un riñón derecho sin función y el riñón izquierdo con morfología conservada y discreta ectasia del sistema calicial superior. También se obtiene una ecografía abdominal que corrobora los hallazgos de la gammagrafía renal. La paciente abandona el tratamiento antibiótico y el seguimiento en consultas a los 6 meses, por problemas sociales, a pesar de persistencia de enfermedad en los cultivos. Un año después del diagnóstico se reinicia el tratamiento médico que se mantuvo durante un año con seguimiento clínico adecuado. Se realiza una urografía intravenosa, con diagnostico de riñón mastic derecho y estenosis de los últimos cms de uréter izquierdo. Se procedió a nefrectomía derecha y se intentó reimplante uretero-vesical izquierdo durante el cual se produjo desinserción del uréter izquierdo a 1 cm por debajo de la unión pieloureteral, por lo que se decide una derivación urinaria permanente izquierda (nefrostomía en raqueta). Durante tres años se mantuvo con buena función renal y cambios periódicos de nefrostomía en raqueta con la evidente limitación y afectación de su calidad de vida. Pasado este tiempo y dado el buen estado físico y la edad de la paciente, se planteó reconstrucción de la vía excretora con ileon. La evaluación preoperatorio confirmó retracción vesical completa por lo que se planteó la sustitución simultánea de este órgano. La técnica quirúrgica realizada consistió en liberar y desfuncionalizar 60 cm de íleon con apertura de mesocolon izquierdo para permitir la anastomosis del extremo proximal del íleon a la pelvis del riñón izquierdo, con sutura a puntos sueltos y catéter de tutorización doble J. Posteriormente se realizó cistectomía e histerectomía de útero miomatoso por dificultar la anastomosis entre neovejiga y uretra, con destubulización de 30 cm de íleon distal en posición isoperistáltica, conformando una neovejiga en "U" con plegadura tipo Camey modificada de los 20 cm finales. El postoperatorio cursa sin incidencias con buena evolución clínica y retirada de tutor ureteral a los 21 días de la cirugía. Cistograma comprobándose la estanqueidad de la sutura vesical, aunque se observa la presencia de reflujo vésico-ureteral, con alta presión. Tras retirada de nefrostomía y sonda vesical fue alta hospitalaria con micción horaria y escapes entre micciones, precisando compresas y maniobra de Credé para vaciar vejiga. A los seis meses cistografía con vejiga de más capacidad y escaso reflujo, persistiendo incontinencia nocturna. Durante las revisiones periódicas que se realizan cada 6 meses, la paciente nos muestra su satisfacción por los resultados obtenidos tras la cirugía y su mejoría en la calidad de vida, ya que no tiene derivación urinaria y los escapes de orina son escasos y nocturnos. En la actualidad, tras 4 años de la última intervención quirúrgica, tiene micciones cada 2-3 horas con continencia diurna y una compresa nocturna, vaciado vesical a expensas de maniobra de Credé y Valsalva sin residuo posterior, necesitando para control metabólico adecuado 1 g diario de bicarbonato oral y una Creatinina plasmática de 1,1 mg/dl7. Responsable clínico: Dra. Raquel González Resina Servicio de Urología Hospital Universitario Virgen del Rocío Avda. Manuel Siurot, s/n - 41013 Sevilla Tel.: 955 012 000 E-mail autor: raqgores@yahoo.es

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"neovejiga", "en", "\"", "U", "\"", "con", "plegadura", "tipo", "Camey", "modificada", "de", "los", "20", "cm", "finales", ".", "\n", "El", "postoperatorio", "cursa", "sin", "incidencias", "con", "buena", "evolución", "clínica", "y", "retirada", "de", "tutor", "ureteral", "a", "los", "21", "días", "de", "la", "cirugía", ".", "Cistograma", "comprobándose", "la", "estanqueidad", "de", "la", "sutura", "vesical", ",", "aunque", "se", "observa", "la", "presencia", "de", "reflujo", "vésico", "-", "ureteral", ",", "con", "alta", "presión", ".", "Tras", "retirada", "de", "nefrostomía", "y", "sonda", "vesical", "fue", "alta", "hospitalaria", "con", "micción", "horaria", "y", "escapes", "entre", "micciones", ",", "precisando", "compresas", "y", "maniobra", "de", "Credé", "para", "vaciar", "vejiga", ".", "\n", "A", "los", "seis", "meses", "cistografía", "con", "vejiga", "de", "más", "capacidad", "y", "escaso", "reflujo", ",", "persistiendo", "incontinencia", "nocturna", ".", "\n", "Durante", "las", "revisiones", "periódicas", "que", "se", "realizan", "cada", "6", "meses", ",", "la", "paciente", "nos", "muestra", "su", "satisfacción", "por", "los", "resultados", "obtenidos", "tras", "la", "cirugía", "y", "su", "mejoría", "en", "la", "calidad", "de", "vida", ",", "ya", "que", "no", "tiene", "derivación", "urinaria", "y", "los", "escapes", "de", "orina", "son", "escasos", "y", "nocturnos", ".", "\n", "En", "la", "actualidad", ",", "tras", "4", "años", "de", "la", "última", "intervención", "quirúrgica", ",", "tiene", "micciones", "cada", "2", "-", "3", "horas", "con", "continencia", "diurna", "y", "una", "compresa", "nocturna", ",", "vaciado", "vesical", "a", "expensas", "de", "maniobra", "de", "Credé", "y", "Valsalva", "sin", "residuo", "posterior", ",", "necesitando", "para", "control", "metabólico", "adecuado", "1", "g", "diario", "de", "bicarbonato", "oral", "y", "una", "Creatinina", "plasmática", "de", "1,1", "mg", "/", "dl7", ".", "\n", "Responsable", "clínico", ":", "Dra", ".", "Raquel", "González", "Resina", "Servicio", "de", "Urología", "Hospital", "Universitario", "Virgen", "del", "Rocío", "Avda", ".", "Manuel", "Siurot", ",", "s", "/", "n", "-", "41013", "Sevilla", "Tel", ".", ":", "955", "012", "000", "E", "-", "mail", "autor", ":", "raqgores@yahoo.es", "\n" ]

[ "HOSPITAL", "CALLE", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "ID_ASEGURAMIENTO", "NOMBRE_SUJETO_ASISTENCIA", "NUMERO_TELEFONO", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "ID_CONTACTO_ASISTENCIAL", "ID_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]

granulocyte - macrophage colony - stimulating factor promoter is a DNA_domain_or_region, T cells is a cell_type, Elf-1 is a protein_molecule, AP-1 is a protein_molecule, transcription factors is a protein_family_or_group

17530_task0

Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_family_or_group, protein_molecule

[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]

Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.

[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]

[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]

granulocyte - macrophage colony - stimulating factor promoter is a DNA_domain_or_region, T cells is a cell_type, Elf-1 is a protein_molecule, AP-1 is a protein_molecule, transcription factors is a protein_family_or_group

17530_task1

Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please typing these entity words according to sentence: granulocyte - macrophage colony - stimulating factor promoter, T cells, Elf-1, AP-1, transcription factors Options: cell_type, DNA_domain_or_region, protein_family_or_group, protein_molecule

[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]

Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.

[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]

[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]

granulocyte - macrophage colony - stimulating factor promoter, T cells, Elf-1, AP-1, transcription factors

17530_task2

Sentence: Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "B-protein_family_or_group", "I-protein_family_or_group", "O" ]

Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.

[ "Activation", "of", "the", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", "promoter", "in", "T", "cells", "requires", "cooperative", "binding", "of", "Elf-1", "and", "AP-1", "transcription", "factors", "." ]

[ "DNA_domain_or_region", "protein_molecule", "protein_complex", "cell_type", "other_name", "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_family_or_group", "cell_line", "" ]

technique is an umlsterm, finger is an umlsterm, arthrodesis is an umlsterm, technique is an umlsterm, fingers is an umlsterm, method is an umlsterm, formaldehyde is an umlsterm, fingers is an umlsterm, fingers is an umlsterm, standard is an umlsterm, wire is an umlsterm, direction is an umlsterm, torque is an umlsterm, torque is an umlsterm, fracture is an umlsterm, method is an umlsterm, finger joint is an umlsterm, arthrodesis is an umlsterm

DerUnfallchirurg.91020466.eng.abstr_task0

Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .

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[ "umlsterm" ]

technique is an umlsterm, finger is an umlsterm, arthrodesis is an umlsterm, technique is an umlsterm, fingers is an umlsterm, method is an umlsterm, formaldehyde is an umlsterm, fingers is an umlsterm, fingers is an umlsterm, standard is an umlsterm, wire is an umlsterm, direction is an umlsterm, torque is an umlsterm, torque is an umlsterm, fracture is an umlsterm, method is an umlsterm, finger joint is an umlsterm, arthrodesis is an umlsterm

DerUnfallchirurg.91020466.eng.abstr_task1

Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please typing these entity words according to sentence: technique, finger, arthrodesis, technique, fingers, method, formaldehyde, fingers, fingers, standard, wire, direction, torque, torque, fracture, method, finger joint, arthrodesis Options: umlsterm

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Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .

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[ "umlsterm" ]

technique, finger, arthrodesis, technique, fingers, method, formaldehyde, fingers, fingers, standard, wire, direction, torque, torque, fracture, method, finger joint, arthrodesis

DerUnfallchirurg.91020466.eng.abstr_task2

Sentence: Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces . Instructions: please extract entity words from the input sentence

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Dorsal tension band fixation is a wide-spread technique of finger arthrodesis . When using a resorbable PDS-suture as tension band fixation a costly implant removal is not needed . Aim of this study is the investigation of the primary stability of this technique in combination with the cup-in-cone-procedure . Freeze-preserved fingers with thread tension band fixation using the PDS-material ( series 1 ) , the same fixating method on formaldehyde preserved fingers ( series 3 ) , freeze-preserved fingers with a standard tension band fixating ( wire loop , series 2 ) are load in a four-point-bending in the direction of palmarflexion . From 6 degrees onwards the wire-tension-system requires a higher torque for bending , but in case of higher torque frequently leads to fracture . The examination shows that the thread-tension-band method by PDS-loop for the stabilisation of finger joint arthrodesis has a sufficient initial stability against bending forces .

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[ "umlsterm" ]

weighted vests is a Intervention_Physical, second - grade is a Participant_Sample-size, with difficulty attending is a Participant_Condition, intervention is a Intervention_Physical, control is a Intervention_Control, time on task is a Outcome_Mental, with and without a vest is a Intervention_Other, Ten is a Participant_Sample-size, nonweighted vest is a Intervention_Other

53356_task0

Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Control, Participant_Condition, Intervention_Other, Participant_Sample-size, Outcome_Mental

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Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .

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[ "Participant_Condition", "Intervention_Other", "Intervention_Physical", "Outcome_Mental", "Participant_Sample-size", "Intervention_Control" ]

weighted vests is a Intervention_Physical, second - grade is a Participant_Sample-size, with difficulty attending is a Participant_Condition, intervention is a Intervention_Physical, control is a Intervention_Control, time on task is a Outcome_Mental, with and without a vest is a Intervention_Other, Ten is a Participant_Sample-size, nonweighted vest is a Intervention_Other

53356_task1

Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please typing these entity words according to sentence: weighted vests, second - grade, with difficulty attending, intervention, control, time on task, with and without a vest, Ten, nonweighted vest Options: Intervention_Physical, Intervention_Control, Participant_Condition, Intervention_Other, Participant_Sample-size, Outcome_Mental

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Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .

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[ "Participant_Condition", "Intervention_Other", "Intervention_Physical", "Outcome_Mental", "Participant_Sample-size", "Intervention_Control" ]

weighted vests, second - grade, with difficulty attending, intervention, control, time on task, with and without a vest, Ten, nonweighted vest

53356_task2

Sentence: Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process . Instructions: please extract entity words from the input sentence

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Pilot study of the effectiveness of weighted vests . OBJECTIVE In this pilot study , we determined the effectiveness of a weighted vest on attention to task for second-grade general education students with difficulty attending . METHOD We used an intervention and a control group and an ABA design to compare participants ' percentage of time on task with and without a vest . Ten participants from nine elementary schools in a suburban Texas school district were randomly assigned to an intervention or a control group . Control group participants wore a nonweighted vest . Participants , classroom teachers , and research assistants who coded the data were blind as to the group to which the participants were assigned . RESULTS A repeated measures analysis of variance indicated no significant differences between groups or between baseline , intervention , and withdrawal conditions . CONCLUSION Our results indicated that the weighted vests were not effective in increasing time on task . These results should be generalized cautiously owing to the small sample size and participant selection process .

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[ "Participant_Condition", "Intervention_Other", "Intervention_Physical", "Outcome_Mental", "Participant_Sample-size", "Intervention_Control" ]

Diagnostik is an umlsterm, Zeit is an umlsterm, Sicherheit is an umlsterm, Menschen is an umlsterm, Hirnregionen is an umlsterm, Elektrokrampftherapie is an umlsterm, Erweiterung is an umlsterm

DerNervenarzt.70680274.ger.abstr_task0

Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .

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[ "umlsterm" ]

Diagnostik is an umlsterm, Zeit is an umlsterm, Sicherheit is an umlsterm, Menschen is an umlsterm, Hirnregionen is an umlsterm, Elektrokrampftherapie is an umlsterm, Erweiterung is an umlsterm

DerNervenarzt.70680274.ger.abstr_task1

Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please typing these entity words according to sentence: Diagnostik, Zeit, Sicherheit, Menschen, Hirnregionen, Elektrokrampftherapie, Erweiterung Options: umlsterm

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Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .

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[ "umlsterm" ]

Diagnostik, Zeit, Sicherheit, Menschen, Hirnregionen, Elektrokrampftherapie, Erweiterung

DerNervenarzt.70680274.ger.abstr_task2

Sentence: Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte . Instructions: please extract entity words from the input sentence

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Die transkranielle Magnetstimulation ( TMS ) ist ein Verfahren , das seit nunmehr einer Dekade in der neurologischen Diagnostik zur Untersuchung der motorischen Bahnsysteme routinemaessig eingesetzt wird . Aus dieser Zeit ist die TMS bezueglich der Sicherheit in der Anwendung am Menschen gut untersucht und hat sich als sicher und nebenwirkungsfrei erwiesen . Seit wenigen Jahren wird die Moeglichkeit untersucht , mittels der TMS nichtinvasiv tiefere Hirnregionen elektrisch zu stimulieren und so , in Analogie zur Elektrokrampftherapie , eine antidepressive Wirkung zu erzielen . Dies haette grosse Vorteile , da dieses Verfahren schonend und ohne Narkose angewendet werden kann . Mehrere Einzelfallanwendungen , aber auch schon mehrere klinisch kontrollierte Studien lassen z . Z. die begruendete Hoffnung zu , dass dieses Verfahren zu einer Erweiterung des Spektrums antidepressiver Behandlungsverfahren fuehren koennte .

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[ "umlsterm" ]

complications is an umlsterm, chiropractic is an umlsterm, treatments is an umlsterm, articulations is an umlsterm, contraindications is an umlsterm, dislocation is an umlsterm, associations is an umlsterm, risks is an umlsterm, findings is an umlsterm, tumor is an umlsterm, bones is an umlsterm, patient is an umlsterm

ManuelleMedizin.90370197.eng.abstr_task0

Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .

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[ "umlsterm" ]

complications is an umlsterm, chiropractic is an umlsterm, treatments is an umlsterm, articulations is an umlsterm, contraindications is an umlsterm, dislocation is an umlsterm, associations is an umlsterm, risks is an umlsterm, findings is an umlsterm, tumor is an umlsterm, bones is an umlsterm, patient is an umlsterm

ManuelleMedizin.90370197.eng.abstr_task1

Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please typing these entity words according to sentence: complications, chiropractic, treatments, articulations, contraindications, dislocation, associations, risks, findings, tumor, bones, patient Options: umlsterm

[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .

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[ "umlsterm" ]

complications, chiropractic, treatments, articulations, contraindications, dislocation, associations, risks, findings, tumor, bones, patient

ManuelleMedizin.90370197.eng.abstr_task2

Sentence: Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Severe complications after chiropractic treatments rarely occur . They happen mostly when manipulating the atlantoaxial and the craniovertebral articulations or when not attending to the contraindications like partial dislocation and hemivertebra . Therefore , x-ray pictures from the part of the vertebral region to be treated are inevitable and likewise the medical scientific associations demand them uniformly to minimize the risks . Nevertheless , our case-report shows also inconspicuous radiological findings do not exclude local tumor infestation of the bones with possible deleterious results for the patient treated by the chiropractor .

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[ "umlsterm" ]

Abstract is an umlsterm, Biopsy is an umlsterm, skin is an umlsterm, patients is an umlsterm, lichen planus is an umlsterm, treatment is an umlsterm, murine is an umlsterm, monoclonal antibodies is an umlsterm, adhesion molecules is an umlsterm, contrast is an umlsterm, biopsies is an umlsterm, PUVA therapy is an umlsterm, skin is an umlsterm, HLA - DR is an umlsterm, keratinocytes is an umlsterm, cells is an umlsterm, cell - cell is an umlsterm, cell - matrix adhesion is an umlsterm, patients is an umlsterm

DerHautarzt.40450161.eng.abstr_task0

Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .

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[ "umlsterm" ]

Abstract is an umlsterm, Biopsy is an umlsterm, skin is an umlsterm, patients is an umlsterm, lichen planus is an umlsterm, treatment is an umlsterm, murine is an umlsterm, monoclonal antibodies is an umlsterm, adhesion molecules is an umlsterm, contrast is an umlsterm, biopsies is an umlsterm, PUVA therapy is an umlsterm, skin is an umlsterm, HLA - DR is an umlsterm, keratinocytes is an umlsterm, cells is an umlsterm, cell - cell is an umlsterm, cell - matrix adhesion is an umlsterm, patients is an umlsterm

DerHautarzt.40450161.eng.abstr_task1

Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please typing these entity words according to sentence: Abstract, Biopsy, skin, patients, lichen planus, treatment, murine, monoclonal antibodies, adhesion molecules, contrast, biopsies, PUVA therapy, skin, HLA - DR, keratinocytes, cells, cell - cell, cell - matrix adhesion, patients Options: umlsterm

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Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .

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[ "umlsterm" ]

Abstract, Biopsy, skin, patients, lichen planus, treatment, murine, monoclonal antibodies, adhesion molecules, contrast, biopsies, PUVA therapy, skin, HLA - DR, keratinocytes, cells, cell - cell, cell - matrix adhesion, patients

DerHautarzt.40450161.eng.abstr_task2

Sentence: Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP . Instructions: please extract entity words from the input sentence

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Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP .

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[ "umlsterm" ]

Patienten is an umlsterm, Diagnose is an umlsterm, Vena cava inferior is an umlsterm, Therapiemodalitaeten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Lymphknoten is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Dissektion is an umlsterm, therapieinduzierten is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm

DerUrologeA.90380460.ger.abstr_task0

Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .

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[ "umlsterm" ]

Patienten is an umlsterm, Diagnose is an umlsterm, Vena cava inferior is an umlsterm, Therapiemodalitaeten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Lymphknoten is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Dissektion is an umlsterm, therapieinduzierten is an umlsterm, Mortalitaet is an umlsterm, Patienten is an umlsterm

DerUrologeA.90380460.ger.abstr_task1

Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please typing these entity words according to sentence: Patienten, Diagnose, Vena cava inferior, Therapiemodalitaeten, Behandlung, Patienten, Lymphknoten, Fernmetastasen, Patienten, Dissektion, therapieinduzierten, Mortalitaet, Patienten Options: umlsterm

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Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .

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[ "umlsterm" ]

Patienten, Diagnose, Vena cava inferior, Therapiemodalitaeten, Behandlung, Patienten, Lymphknoten, Fernmetastasen, Patienten, Dissektion, therapieinduzierten, Mortalitaet, Patienten

DerUrologeA.90380460.ger.abstr_task2

Sentence: Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden . Instructions: please extract entity words from the input sentence

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Bei 4-10 % aller Patienten mit der Diagnose eines Nierenzellkarzinomes ( NCC ) wird die gleichzeitige Propagation eines Tumorthrombus in die Vena cava inferior bzw. das rechte Atrium beobachtet . Juengste Untersuchungen belegten die fehlende Bedeutung des Kavathrombus im Sinne einer biologischen Variable von unabhaengiger prognostischer Relevanz . Obwohl sich aufgrund der fehlenden Verfuegbarkeit suffizienter konservativ-medizinischer Therapiemodalitaeten in der Behandlung des NCC der Versuch einer moeglichst kompletten chirurgischen Sanierung von Patienten mit Kavathrombus und ohne gleichzeitigen Nachweis regionaler Lymphknoten - oder Fernmetastasen in der klinischen Routine weitgehend etabliert hat , bleiben verschiedene Fragen , diese therapeutische Strategie betreffend , Gegenstand aktueller Diskussion . In der vorliegenden Untersuchung an 92 Patienten mit Nierenzellkarzinom und Kavathrombus konnte gezeigt werden , dass im Vergleich mit konventionellen gefaesschirurgischen Behandlungsansaetzen insbesondere die Dissektion rechts-atrial propagierender Tumorthromben mittels extrakorporaler Zirkulation und kardialem Arrest offensichtlich nicht in einer hoeheren therapieinduzierten Mortalitaet resultiert . Demgegenueber wurde , wie juengst postuliert , eine aus dieser operativen Strategie resultierende positive Beeinflussung des Langzeitueberlebens der Patienten nicht beobachtet . Auch die unabhaengig vom Operationsverfahren wiederholt diskutierte prognostische Bedeutung der kranialen Thrombusextension konnte in der vorliegenden Untersuchung nicht bestaetigt werden .

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[ "umlsterm" ]

pulp is a Tissue, pulp is a Tissue, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulpal is a Tissue, tooth is a Organ, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, pulp is a Tissue

PMID-18565374_task0

Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Tissue, Organ

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Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.

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[ "Pathological_formation", "Tissue", "Organ" ]

pulp is a Tissue, pulp is a Tissue, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulpal is a Tissue, tooth is a Organ, teeth is a Organ, pulp is a Tissue, cariously is a Pathological_formation, teeth is a Organ, pulp is a Tissue, pulp is a Tissue

PMID-18565374_task1

Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please typing these entity words according to sentence: pulp, pulp, pulp, cariously, teeth, pulp, cariously, teeth, pulpal, tooth, teeth, pulp, cariously, teeth, pulp, pulp Options: Pathological_formation, Tissue, Organ

[ "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Pathological_formation", "O", "O", "B-Organ", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O" ]

Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.

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[ "Pathological_formation", "Tissue", "Organ" ]

pulp, pulp, pulp, cariously, teeth, pulp, cariously, teeth, pulpal, tooth, teeth, pulp, cariously, teeth, pulp, pulp

PMID-18565374_task2

Sentence: Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties. Instructions: please extract entity words from the input sentence

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Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric dentists and endodontists. Opinions on 3 areas were sought: pulp therapy for cariously involved primary teeth; indirect pulp treatment (IPT) for cariously involved immature permanent teeth; and innovative treatment options including pulpal revascularization and regeneration. Results were analyzed with chi2 tests. Comparisons of presymposium and postsymposium responses and between the 2 groups of attendees indicated that the pediatric dentistry and endodontic communities agree that formocresol will be replaced as a primary tooth pulpotomy agent, that mineral trioxide is the first choice to take its place, that IPT in primary teeth holds hope as a replacement for pulpotomy, and that IPT is an acceptable pulp therapy technique for cariously involved young permanent teeth. Both groups believe that pulp revascularization and regeneration will be viable treatment modalities in the future. The AAE and the AAPD are positioned to begin preparation of best practice guidelines that share common language and treatment recommendations for pulp therapies performed by both specialties.

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[ "Pathological_formation", "Tissue", "Organ" ]

actin - binding protein is a Gene/protein/RNA, talin is a Gene/protein/RNA, pp60src is a Gene/protein/RNA

36_task0

Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).

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[ "Gene/protein/RNA" ]

actin - binding protein is a Gene/protein/RNA, talin is a Gene/protein/RNA, pp60src is a Gene/protein/RNA

36_task1

Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please typing these entity words according to sentence: actin - binding protein, talin, pp60src Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).

[ "Addition", "of", "EGTA", "(", "3", "mM", ")", "to", "the", "extracellular", "media", "completely", "inhibited", "the", "cleavage", "of", "actin", "-", "binding", "protein", ",", "talin", ",", "and", "pp60src", "in", "response", "to", "A23187", "(", "1", "microM", ")", "." ]

[ "Gene/protein/RNA" ]

actin - binding protein, talin, pp60src

36_task2

Sentence: Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Addition of EGTA (3 mM) to the extracellular media completely inhibited the cleavage of actin-binding protein, talin, and pp60src in response to A23187 (1 microM).

[ "Addition", "of", "EGTA", "(", "3", "mM", ")", "to", "the", "extracellular", "media", "completely", "inhibited", "the", "cleavage", "of", "actin", "-", "binding", "protein", ",", "talin", ",", "and", "pp60src", "in", "response", "to", "A23187", "(", "1", "microM", ")", "." ]

[ "Gene/protein/RNA" ]

rivastigmine is a CHEMICAL, acetylcholine is a CHEMICAL, acetylcholinesterase is a GENE-Y, AchE is a GENE-Y, C - reactive protein is a GENE-Y, CRP is a GENE-Y, nuclear factor kappa - B is a GENE-N, NF - κB is a GENE-N, monocyte chemoattractant protein-1 is a GENE-Y, MCP-1 is a GENE-Y, AlCl3 is a CHEMICAL, AchE is a GENE-Y, CRP is a GENE-Y, NF - κB is a GENE-N, MCP-1 is a GENE-Y

13699_task0

Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL

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Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

rivastigmine is a CHEMICAL, acetylcholine is a CHEMICAL, acetylcholinesterase is a GENE-Y, AchE is a GENE-Y, C - reactive protein is a GENE-Y, CRP is a GENE-Y, nuclear factor kappa - B is a GENE-N, NF - κB is a GENE-N, monocyte chemoattractant protein-1 is a GENE-Y, MCP-1 is a GENE-Y, AlCl3 is a CHEMICAL, AchE is a GENE-Y, CRP is a GENE-Y, NF - κB is a GENE-N, MCP-1 is a GENE-Y

13699_task1

Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. Instructions: please typing these entity words according to sentence: rivastigmine, acetylcholine, acetylcholinesterase, AchE, C - reactive protein, CRP, nuclear factor kappa - B, NF - κB, monocyte chemoattractant protein-1, MCP-1, AlCl3, AchE, CRP, NF - κB, MCP-1 Options: GENE-N, GENE-Y, CHEMICAL

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Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

rivastigmine, acetylcholine, acetylcholinesterase, AchE, C - reactive protein, CRP, nuclear factor kappa - B, NF - κB, monocyte chemoattractant protein-1, MCP-1, AlCl3, AchE, CRP, NF - κB, MCP-1

13699_task2

Sentence: Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. Instructions: please extract entity words from the input sentence

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Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. Abstract This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Patienten is an umlsterm, Pharmaka is an umlsterm, Medikamenten is an umlsterm, Gensequenzen is an umlsterm, ionisierender Strahlung is an umlsterm, Patientenzahlen is an umlsterm, Strahlentherapie is an umlsterm, Therapie is an umlsterm, Therapieform is an umlsterm

ZfuerKardiologie.8087s166.ger.abstr_task0

Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .

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[ "umlsterm" ]

Patienten is an umlsterm, Pharmaka is an umlsterm, Medikamenten is an umlsterm, Gensequenzen is an umlsterm, ionisierender Strahlung is an umlsterm, Patientenzahlen is an umlsterm, Strahlentherapie is an umlsterm, Therapie is an umlsterm, Therapieform is an umlsterm

ZfuerKardiologie.8087s166.ger.abstr_task1

Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please typing these entity words according to sentence: Patienten, Pharmaka, Medikamenten, Gensequenzen, ionisierender Strahlung, Patientenzahlen, Strahlentherapie, Therapie, Therapieform Options: umlsterm

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Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .

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[ "umlsterm" ]

Patienten, Pharmaka, Medikamenten, Gensequenzen, ionisierender Strahlung, Patientenzahlen, Strahlentherapie, Therapie, Therapieform

ZfuerKardiologie.8087s166.ger.abstr_task2

Sentence: Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann . Instructions: please extract entity words from the input sentence

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Die Restenose nach Koronarangioplastie ist ein klinisches Problem , welches bei 20-50% der behandelten Patienten auftritt . Es zeigte sich in den vergangenen Jahren , dass durch die systemische Gabe einer Vielzahl von Pharmaka die Restenoserate unter klinischen Bedingungen nicht signifikant gesenkt werden kann . Neue vielversprechende Ansaetze , eroeffnen sich durch die lokale , kathetergestuetzte Applikation von Medikamenten , von antiproliferativ wirkenden Gensequenzen oder von ionisierender Strahlung . Experimentelle Untersuchungen und vorlaeufige klinische Studien mit kleinen Patientenzahlen legen nahe , dass durch die kathetergestuetzte Strahlentherapie eine sichere und effektive Therapie der Restenose moeglich ist . Weitere randomisierte , multizentrische Studien mit langer Nachbeobachtungszeit muessen jedoch folgen , bevor diese Therapieform generell empfohlen werden kann .

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[ "umlsterm" ]

free radical disturbances and endotoxicosis is a Outcome_Physical, complex antioxidant cytoflavin is a Intervention_Pharmacological, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level is a Outcome_Physical, artificial lung ventilation is a Outcome_Other, staying in critical condition is a Outcome_Other, course of complications is a Outcome_Adverse-effects

53458_task0

Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Outcome_Adverse-effects

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[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]

free radical disturbances and endotoxicosis is a Outcome_Physical, complex antioxidant cytoflavin is a Intervention_Pharmacological, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level is a Outcome_Physical, artificial lung ventilation is a Outcome_Other, staying in critical condition is a Outcome_Other, course of complications is a Outcome_Adverse-effects

53458_task1

Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please typing these entity words according to sentence: free radical disturbances and endotoxicosis, complex antioxidant cytoflavin, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level, artificial lung ventilation, staying in critical condition, course of complications Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Outcome_Adverse-effects

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[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]

free radical disturbances and endotoxicosis, complex antioxidant cytoflavin, recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level, artificial lung ventilation, staying in critical condition, course of complications

53458_task2

Sentence: [ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications . Instructions: please extract entity words from the input sentence

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[ Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period ] . The examination and treatment of 64 patients have shown that inclusion of complex antioxidant cytoflavin in intensive therapy at the postoperative period of diffuse peritonitis allows the hypoxia degree to be decreased that in its turn results in quicker recovery of the antioxidant system and decreased activity of peroxidation and endotoxicosis level . The clinical course of the postoperative period of diffuse peritonitis with cytoflavin included in intensive therapy is characterized by shorter terms of artificial lung ventilation , shorter time of staying in critical condition , more favorable course of complications .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Adverse-effects" ]

Audiometrie is an umlsterm, Kindern is an umlsterm, Audiometriekopfhoerer is an umlsterm, Hoerschwellenpegel is an umlsterm, Schalldruckpegel is an umlsterm, Kindern is an umlsterm, Hoerschwellen is an umlsterm, Kindern is an umlsterm, normalhoerender is an umlsterm, Laerm is an umlsterm, Audiometriebereich is an umlsterm, Ohres is an umlsterm

HNO.70450147.ger.abstr_task0

Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .

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[ "umlsterm" ]

Audiometrie is an umlsterm, Kindern is an umlsterm, Audiometriekopfhoerer is an umlsterm, Hoerschwellenpegel is an umlsterm, Schalldruckpegel is an umlsterm, Kindern is an umlsterm, Hoerschwellen is an umlsterm, Kindern is an umlsterm, normalhoerender is an umlsterm, Laerm is an umlsterm, Audiometriebereich is an umlsterm, Ohres is an umlsterm

HNO.70450147.ger.abstr_task1

Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please typing these entity words according to sentence: Audiometrie, Kindern, Audiometriekopfhoerer, Hoerschwellenpegel, Schalldruckpegel, Kindern, Hoerschwellen, Kindern, normalhoerender, Laerm, Audiometriebereich, Ohres Options: umlsterm

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Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .

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[ "umlsterm" ]

Audiometrie, Kindern, Audiometriekopfhoerer, Hoerschwellenpegel, Schalldruckpegel, Kindern, Hoerschwellen, Kindern, normalhoerender, Laerm, Audiometriebereich, Ohres

HNO.70450147.ger.abstr_task2

Sentence: Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu . Instructions: please extract entity words from the input sentence

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Nach Entwicklung von geeigneten Kopfhoerern ist die Audiometrie im erweiterten Hochtonbereich ( 8 kHz-16 kHz ) auch unter klinischen Bedingungen moeglich . Bei der vorliegenden Untersuchung wurde das Hoervermoegen von 35 Kindern im Vorschulalter ( 4-7 Jahre ) im Frequenzbereich von 8 kHz-16 kHz mit dem neuen Audiometriekopfhoerer HDA 200 ( Fa. Sennheiser ) geprueft . Die mittleren Hoerschwellenpegel ergeben am Kuppler B&K 4153 ( entsprechend Normentwurf IEC 29/299/CD) im Median mit Standardabweichung bei 10 kHz einen Schalldruckpegel von 25 dB +/- 12 dB , bei 12,5 kHz : 35 dB +/- 12 dB und bei 16 kHz : 50 dB +/- 15 dB . Bei den aelteren Kindern des Kollektivs ( > 5 Jahre ) waren die Hoerschwellen zuverlaessiger zu ermitteln und lagen um ca. 10 dB guenstiger als bei juengeren Kindern ( 5 Jahre ) . Bei 10 kHz-14 kHz entsprechen sie etwa denen normalhoerender junger Erwachsener und sind aber bei 16 kHz um 10 dB-15 dB empfindlicher . Da im Bereich ueber 10 kHz das Gehoer durch Alter , Laerm und toxische Einfluesse in groesserem Ausmass als im konventionellem Audiometriebereich geschaedigt wird , lassen diese Untersuchungen Rueckschluesse auf ein physiologisches Normalgehoer " " des ( noch ) ungeschaedigten Ohres zu .

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[ "umlsterm" ]

REST is a Genes/Proteins

1751_task0

Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes/Proteins

[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The transcription factor REST silences neuronal gene expression in non-neuronal cells.

[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]

REST is a Genes/Proteins

1751_task1

Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please typing these entity words according to sentence: REST Options: Genes/Proteins

[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The transcription factor REST silences neuronal gene expression in non-neuronal cells.

[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]

REST

1751_task2

Sentence: The transcription factor REST silences neuronal gene expression in non-neuronal cells. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The transcription factor REST silences neuronal gene expression in non-neuronal cells.

[ "The", "transcription", "factor", "REST", "silences", "neuronal", "gene", "expression", "in", "non", "-", "neuronal", "cells", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Non-Specific_miRNAs", "Species", "Specific_miRNAs" ]

active physical training is a Intervention_Physical, adductor - related groin pain is a Participant_Condition, athletes is a Participant_Condition, active training programme ( AT ) is a Intervention_Physical, physiotherapy treatment without active training ( PT ) is a Intervention_Physical, 68 is a Participant_Sample-size, full return to sports at the same level without groin pain is a Outcome_Pain

93794_task0

Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Pain, Participant_Condition, Participant_Sample-size

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Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .

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[ "Outcome_Pain", "Intervention_Physical", "Participant_Condition", "Participant_Sample-size" ]

active physical training is a Intervention_Physical, adductor - related groin pain is a Participant_Condition, athletes is a Participant_Condition, active training programme ( AT ) is a Intervention_Physical, physiotherapy treatment without active training ( PT ) is a Intervention_Physical, 68 is a Participant_Sample-size, full return to sports at the same level without groin pain is a Outcome_Pain

93794_task1

Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please typing these entity words according to sentence: active physical training, adductor - related groin pain, athletes, active training programme ( AT ), physiotherapy treatment without active training ( PT ), 68, full return to sports at the same level without groin pain Options: Intervention_Physical, Outcome_Pain, Participant_Condition, Participant_Sample-size

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Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .

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[ "Outcome_Pain", "Intervention_Physical", "Participant_Condition", "Participant_Sample-size" ]

active physical training, adductor - related groin pain, athletes, active training programme ( AT ), physiotherapy treatment without active training ( PT ), 68, full return to sports at the same level without groin pain

93794_task2

Sentence: Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials . Instructions: please extract entity words from the input sentence

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Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes : randomised trial . BACKGROUND Groin pain is common among athletes . A major cause of long-standing problems is adductor-related groin pain . The purpose of this randomised clinical trial was to compare an active training programme ( AT ) with a physiotherapy treatment without active training ( PT ) in the treatment of adductor-related groin pain in athletes . METHODS 68 athletes with long-standing ( median 40 weeks ) adductor-related groin pain -- after examination according to a standardised protocol -- were randomly assigned to AT or PT . The treatment period was 8-12 weeks . 4 months after the end of treatment a standardised examination was done . The examining physician was unaware of the treatment allocation . The ultimate outcome measure was full return to sports at the same level without groin pain . Analyses were by intention to treat . FINDINGS 23 patients in the AT group and four in the PT group returned to sports without groin pain ( odds ratio , multiple-logistic-regression analysis , 12.7 [ 95 % CI 3.4-47.2 ] ) . The subjective global assessments of the effect of the treatments showed a significant ( p=0.006 ) linear trend towards a better effect in the AT group . A per-protocol analysis did not show appreciably different results . INTERPRETATION AT with a programme aimed at improving strength and coordination of the muscles acting on the pelvis , in particular the adductor muscles , is very effective in the treatment of athletes with long-standing adductor-related groin pain . The potential preventive value of a short programme based upon the principles of AT should be assessed in future , randomised , clinical trials .

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[ "Outcome_Pain", "Intervention_Physical", "Participant_Condition", "Participant_Sample-size" ]

Ala797Thr is a SNP, beta - myosin heavy - chain gene is a Gene, betaMHC is a Gene, Arg92Trp is a SNP, cardiac troponin T gene is a Gene, cTnT is a Gene, Arg645His is a SNP, myosin - binding protein C gene is a Gene, betaMHC is a Gene, Arg403Trp is a SNP, Arg249Gln is a SNP, Gln499Lys is a SNP, betaMHC is a Gene, Val896Met is a SNP, Deltac756 is a SNP, MyBPC - and is a Gene, betaMHC is a Gene, Arg719Gln is a SNP, betaMHC is a Gene, Arg403Trp is a SNP, Ala797Thr is a SNP, Arg92Trp is a SNP, betaMHC is a Gene, Arg92Trp is a SNP

163_task0

Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP

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The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.

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[ "Gene", "SNP" ]

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163_task1

Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please typing these entity words according to sentence: Ala797Thr, beta - myosin heavy - chain gene, betaMHC, Arg92Trp, cardiac troponin T gene, cTnT, Arg645His, myosin - binding protein C gene, betaMHC, Arg403Trp, Arg249Gln, Gln499Lys, betaMHC, Val896Met, Deltac756, MyBPC - and, betaMHC, Arg719Gln, betaMHC, Arg403Trp, Ala797Thr, Arg92Trp, betaMHC, Arg92Trp Options: Gene, SNP

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The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.

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[ "Gene", "SNP" ]

Ala797Thr, beta - myosin heavy - chain gene, betaMHC, Arg92Trp, cardiac troponin T gene, cTnT, Arg645His, myosin - binding protein C gene, betaMHC, Arg403Trp, Arg249Gln, Gln499Lys, betaMHC, Val896Met, Deltac756, MyBPC - and, betaMHC, Arg719Gln, betaMHC, Arg403Trp, Ala797Thr, Arg92Trp, betaMHC, Arg92Trp

163_task2

Sentence: The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation. Instructions: please extract entity words from the input sentence

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The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk of sudden cardiac death, mostly as adolescents or young adults. The reproductive disadvantage incurred may explain both the global occurrence of diverse independent HCM-associated mutations and the rare reports of founder effects within populations. We have investigated whether this holds true for two South African subpopulations, one of mixed ancestry and one of northern-European descent. Previously, we had detected three novel mutations-Ala797Thr in the beta-myosin heavy-chain gene (betaMHC), Arg92Trp in the cardiac troponin T gene (cTnT), and Arg645His in the myosin-binding protein C gene (MyBPC)-and two documented betaMHC mutations (Arg403Trp and Arg249Gln). Here we report three additional novel mutations-Gln499Lys in betaMHC and Val896Met and Deltac756 in MyBPC-and the documented betaMHC Arg719Gln mutation. Seven of the nine HCM-causing mutations arose independently; no conclusions can be drawn for the remaining two. However, the betaMHC Arg403Trp and Ala797Thr and cTnT Arg92Trp mutations were detected in another one, eight, and four probands, respectively, and haplotype analysis in families carrying these recurring mutations inferred their origin from three common ancestors. The milder phenotype of the betaMHC mutations may account for the presence of these founder effects, whereas population dynamics alone may have overridden the reproductive disadvantage incurred by the more lethal, cTnT Arg92Trp mutation.

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[ "Gene", "SNP" ]

ganciclovir is a NORMALIZABLES, corticoides is a NORMALIZABLES, ciclosporina is a NORMALIZABLES, azatioprina is a NORMALIZABLES, Imurel is a NORMALIZABLES

433_task0

Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES

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Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).

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[ "NORMALIZABLES" ]

ganciclovir is a NORMALIZABLES, corticoides is a NORMALIZABLES, ciclosporina is a NORMALIZABLES, azatioprina is a NORMALIZABLES, Imurel is a NORMALIZABLES

433_task1

Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please typing these entity words according to sentence: ganciclovir, corticoides, ciclosporina, azatioprina, Imurel Options: NORMALIZABLES

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Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).

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[ "NORMALIZABLES" ]

ganciclovir, corticoides, ciclosporina, azatioprina, Imurel

433_task2

Sentence: Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®). Instructions: please extract entity words from the input sentence

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Paciente de 42 años diagnosticado de pancolitis ulcerosa en el año 2003, corticodependiente, con un primer episodio cortirrefractario en agosto de 2003 y con sobreinfección por citomegalovirus, que se trató con ganciclovir iv. En mayo de 2004, presentó un brote moderado con diarrea con sangre roja (2 deposiciones diarias) y desde entonces anemia ferropénica crónica que trata con ferroterapia. En el estudio endoscópico se aprecia pancolitis ulcerosa con afectación grave. Recibe tratamiento con corticoides e inmunosupresores. En junio de 2007 presenta un nuevo brote de actividad de la enfermedad con 10-12 deposiciones líquidas diarias, dolor abdominal y fiebre. Debido al empeoramiento clínico y analítico progresivo presentado por el paciente y la mala respuesta al tratamiento convencional, se decide iniciar el tratamiento con granulocitoaféresis asociado a ciclosporina iv. Mientras el paciente estuvo ingresado se realizaron 4 sesiones, siendo precisa la colocación de un catéter de doble luz en la yugular derecha. Hubo que realizar un cambio de catéter central por infección MARSA se realizó aislamiento de contacto).Las 3 sesiones restantes las recibió de forma ambulatoria. Durante estos meses, el paciente ha presentado una mejoría clínica y endoscópica de evolución rápida. Actualmente recibe tratamiento con azatioprina (Imurel®).

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[ "NORMALIZABLES" ]

kidney is a Organ, renal is a Organ, kidney is a Organ, renal is a Organ, renal tubular is a Multi-tissue_structure, tubular cell is a Cell, epithelial cells is a Cell, tubules is a Multi-tissue_structure, tubular is a Multi-tissue_structure, interstitial is a Immaterial_anatomical_entity, tubule is a Multi-tissue_structure, tubular is a Multi-tissue_structure, kidney is a Organ, renal tubular epithelial cells is a Cell

PMID-10644902_task0

Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Multi-tissue_structure, Immaterial_anatomical_entity, Organ, Cell

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Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.

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[ "Cell", "Multi-tissue_structure", "Immaterial_anatomical_entity", "Organ" ]

kidney is a Organ, renal is a Organ, kidney is a Organ, renal is a Organ, renal tubular is a Multi-tissue_structure, tubular cell is a Cell, epithelial cells is a Cell, tubules is a Multi-tissue_structure, tubular is a Multi-tissue_structure, interstitial is a Immaterial_anatomical_entity, tubule is a Multi-tissue_structure, tubular is a Multi-tissue_structure, kidney is a Organ, renal tubular epithelial cells is a Cell

PMID-10644902_task1

Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please typing these entity words according to sentence: kidney, renal, kidney, renal, renal tubular, tubular cell, epithelial cells, tubules, tubular, interstitial, tubule, tubular, kidney, renal tubular epithelial cells Options: Multi-tissue_structure, Immaterial_anatomical_entity, Organ, Cell

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Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.

[ "Obstructive", "nephropathy", ":", "lessons", "from", "cystic", "kidney", "disease", ".", "\n", "Obstructive", "nephropathy", "is", "one", "of", "the", "most", "important", "causes", "of", "renal", "failure", "in", "infants", "and", "children", ",", "while", "polycystic", "kidney", "disease", "(", "PKD", ")", "is", "a", "major", "cause", "of", "renal", "failure", "in", "the", "adult", "population", ".", "This", "review", "summarizes", "the", "evidence", "that", "there", "may", "be", "a", "number", "of", "mechanisms", "common", "to", "the", "pathophysiology", "of", "both", "conditions", ".", "In", "animal", "models", "of", "obstructive", "nephropathy", "and", "PKD", ",", "the", "renal", "tubular", "expression", "of", "epidermal", "growth", "factor", "is", "suppressed", ",", "and", "expression", "of", "clusterin", "is", "increased", ",", "both", "of", "which", "suggest", "arrested", "maturation", "or", "dedifferentiation", "of", "the", "tubular", "cell", ".", "There", "is", "a", "marked", "increase", "in", "apoptosis", "of", "epithelial", "cells", "in", "dilated", "tubules", ",", "associated", "with", "an", "increase", "in", "apoptotic", "stimuli", ".", "The", "renin", "-", "angiotensin", "system", "is", "activated", "in", "both", "obstructive", "nephropathy", "and", "PKD", ",", "which", "may", "contribute", "to", "tubular", "atrophy", "and", "interstitial", "fibrosis", ",", "which", "characterize", "the", "progression", "of", "both", "conditions", ".", "Focal", "cystic", "dilatation", "of", "the", "tubule", "is", "found", "in", "obstructive", "nephropathy", ",", "while", "tubular", "obstruction", "is", "present", "in", "cystic", "kidney", "disease", ".", "It", "is", "therefore", "likely", "that", "elucidation", "of", "the", "effects", "of", "mechanical", "stretch", "on", "renal", "tubular", "epithelial", "cells", "will", "contribute", "to", "our", "understanding", "of", "both", "conditions", ".", "\n" ]

[ "Cell", "Multi-tissue_structure", "Immaterial_anatomical_entity", "Organ" ]

kidney, renal, kidney, renal, renal tubular, tubular cell, epithelial cells, tubules, tubular, interstitial, tubule, tubular, kidney, renal tubular epithelial cells

PMID-10644902_task2

Sentence: Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "B-Immaterial_anatomical_entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Obstructive nephropathy: lessons from cystic kidney disease. Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.

[ "Obstructive", "nephropathy", ":", "lessons", "from", "cystic", "kidney", "disease", ".", "\n", "Obstructive", "nephropathy", "is", "one", "of", "the", "most", "important", "causes", "of", "renal", "failure", "in", "infants", "and", "children", ",", "while", "polycystic", "kidney", "disease", "(", "PKD", ")", "is", "a", "major", "cause", "of", "renal", "failure", "in", "the", "adult", "population", ".", "This", "review", "summarizes", "the", "evidence", "that", "there", "may", "be", "a", "number", "of", "mechanisms", "common", "to", "the", "pathophysiology", "of", "both", "conditions", ".", "In", "animal", "models", "of", "obstructive", "nephropathy", "and", "PKD", ",", "the", "renal", "tubular", "expression", "of", "epidermal", "growth", "factor", "is", "suppressed", ",", "and", "expression", "of", "clusterin", "is", "increased", ",", "both", "of", "which", "suggest", "arrested", "maturation", "or", "dedifferentiation", "of", "the", "tubular", "cell", ".", "There", "is", "a", "marked", "increase", "in", "apoptosis", "of", "epithelial", "cells", "in", "dilated", "tubules", ",", "associated", "with", "an", "increase", "in", "apoptotic", "stimuli", ".", "The", "renin", "-", "angiotensin", "system", "is", "activated", "in", "both", "obstructive", "nephropathy", "and", "PKD", ",", "which", "may", "contribute", "to", "tubular", "atrophy", "and", "interstitial", "fibrosis", ",", "which", "characterize", "the", "progression", "of", "both", "conditions", ".", "Focal", "cystic", "dilatation", "of", "the", "tubule", "is", "found", "in", "obstructive", "nephropathy", ",", "while", "tubular", "obstruction", "is", "present", "in", "cystic", "kidney", "disease", ".", "It", "is", "therefore", "likely", "that", "elucidation", "of", "the", "effects", "of", "mechanical", "stretch", "on", "renal", "tubular", "epithelial", "cells", "will", "contribute", "to", "our", "understanding", "of", "both", "conditions", ".", "\n" ]

[ "Cell", "Multi-tissue_structure", "Immaterial_anatomical_entity", "Organ" ]

poly(ethylene carbonate ) is a CHEMICAL

23639738_task0

Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]

Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.

[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]

[ "CHEMICAL", "GENE-Y" ]

poly(ethylene carbonate ) is a CHEMICAL

23639738_task1

Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please typing these entity words according to sentence: poly(ethylene carbonate ) Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]

Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.

[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]

[ "CHEMICAL", "GENE-Y" ]

poly(ethylene carbonate )

23639738_task2

Sentence: Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O" ]

Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release.

[ "Enzyme", "-", "responsive", "surface", "erosion", "of", "poly(ethylene", "carbonate", ")", "for", "controlled", "drug", "release", "." ]

[ "CHEMICAL", "GENE-Y" ]

Augeninnendruck is an umlsterm, Phakoemulsifikation is an umlsterm

DerOpthalmologe.00970331.ger.abstr_task0

Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .

[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]

[ "umlsterm" ]

Augeninnendruck is an umlsterm, Phakoemulsifikation is an umlsterm

DerOpthalmologe.00970331.ger.abstr_task1

Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please typing these entity words according to sentence: Augeninnendruck, Phakoemulsifikation Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .

[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]

[ "umlsterm" ]

Augeninnendruck, Phakoemulsifikation

DerOpthalmologe.00970331.ger.abstr_task2

Sentence: Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : In einer prospektiven , randomisierten Studie soll ueberprueft werden , ob verschiedene Viskoelastika ( adatocel Amvisc Plus und Healon ) , einen unterschiedlichen postoperativen Augeninnendruck nach Phakoemulsifikation und IOL-Implantation hervorrufen .

[ "Fragestellung", ":", "In", "einer", "prospektiven", ",", "randomisierten", "Studie", "soll", "ueberprueft", "werden", ",", "ob", "verschiedene", "Viskoelastika", "(", "adatocel", "Amvisc", "Plus", "und", "Healon", ")", ",", "einen", "unterschiedlichen", "postoperativen", "Augeninnendruck", "nach", "Phakoemulsifikation", "und", "IOL", "-", "Implantation", "hervorrufen", "." ]

[ "umlsterm" ]

Leukotriene C4 is a compound, IL-8 is a protein, MCP-1 is a protein

DS.d360_task0

Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.

[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]

[ "compound", "protein" ]

Leukotriene C4 is a compound, IL-8 is a protein, MCP-1 is a protein

DS.d360_task1

Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please typing these entity words according to sentence: Leukotriene C4, IL-8, MCP-1 Options: compound, protein

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.

[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]

[ "compound", "protein" ]

Leukotriene C4, IL-8, MCP-1

DS.d360_task2

Sentence: Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. Instructions: please extract entity words from the input sentence

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.

[ "Leukotriene", "C4", "release", "and", "gene", "expressions", "of", "IL-8", "and", "MCP-1", "in", "porcine", "alveolar", "epithelial", "type", "II", "cells", "." ]

[ "compound", "protein" ]

MIP is an umlsterm, diagnostic is an umlsterm, chest is an umlsterm, evaluation is an umlsterm, anatomy is an umlsterm, pathology is an umlsterm

DerRadiologe.90390952.eng.abstr_task0

Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .

[ "Purpose", ":", "To", "test", ",", "whether", "axial", ",", "coronal", "and", "sagittal", "MIP", "and", "MPR", "reconstructions", "of", "diagnostic", "quality", "can", "be", "obtained", "from", "1-mm", "collimation", "MSCT", "data", "of", "the", "chest", "for", "the", "evaluation", "of", "thoracic", "anatomy", "and", "pathology", "." ]

[ "umlsterm" ]

MIP is an umlsterm, diagnostic is an umlsterm, chest is an umlsterm, evaluation is an umlsterm, anatomy is an umlsterm, pathology is an umlsterm

DerRadiologe.90390952.eng.abstr_task1

Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please typing these entity words according to sentence: MIP, diagnostic, chest, evaluation, anatomy, pathology Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .

[ "Purpose", ":", "To", "test", ",", "whether", "axial", ",", "coronal", "and", "sagittal", "MIP", "and", "MPR", "reconstructions", "of", "diagnostic", "quality", "can", "be", "obtained", "from", "1-mm", "collimation", "MSCT", "data", "of", "the", "chest", "for", "the", "evaluation", "of", "thoracic", "anatomy", "and", "pathology", "." ]

[ "umlsterm" ]

MIP, diagnostic, chest, evaluation, anatomy, pathology

DerRadiologe.90390952.eng.abstr_task2

Sentence: Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Purpose : To test , whether axial , coronal and sagittal MIP and MPR reconstructions of diagnostic quality can be obtained from 1-mm collimation MSCT data of the chest for the evaluation of thoracic anatomy and pathology .

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[ "umlsterm" ]

galactose is a compound, beta galactosidase is a protein

DS.d373_task0

Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.

[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]

[ "protein", "compound" ]

galactose is a compound, beta galactosidase is a protein

DS.d373_task1

Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please typing these entity words according to sentence: galactose, beta galactosidase Options: compound, protein

[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.

[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]

[ "protein", "compound" ]

galactose, beta galactosidase

DS.d373_task2

Sentence: The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.

[ "The", "potential", "action", "of", "galactose", "as", "a", "\"", "chemical", "chaperone", "\"", ":", "increase", "of", "beta", "galactosidase", "activity", "in", "fibroblasts", "from", "an", "adult", "GM1-gangliosidosis", "patient", "." ]

[ "protein", "compound" ]

TCR repertoire is a protein_family_or_group, Epstein - Barr virus - encoded transactivator protein is a protein_family_or_group, BZLF1 is a protein_molecule, CD8 + cytotoxic T lymphocytes is a cell_type

55581_task0

Sentence: Selection of a diverse TCR repertoire in response to an Epstein-Barr virus-encoded transactivator protein BZLF1 by CD8+ cytotoxic T lymphocytes during primary and persistent infection. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, protein_molecule

[ "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O" ]

Selection of a diverse TCR repertoire in response to an Epstein-Barr virus-encoded transactivator protein BZLF1 by CD8+ cytotoxic T lymphocytes during primary and persistent infection.

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[ "cell_line", "protein_family_or_group", "multi_cell", "cell_type", "(AND virus virus)", "other_name", "(OR other_name other_name)", "peptide", "(AND cell_line cell_line)", "virus", "protein_domain_or_region", "RNA_molecule", "", "protein_subunit", "DNA_domain_or_region", "protein_molecule" ]