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Genotype is a Measurement, 2 , 3 , 5 or 6 is a Value, infection is a Condition, Decompensated is a Qualifier, cirrhosis is a Condition, actual or previous is a Scope, clinical decompensation is a Condition, ascites is a Condition, hepatic encephalopathy is a Condition, variceal bleeding is a Condition, spontaneous bacterial peritonitis is a Condition, Child - Pugh is a Measurement, Hepatocellular carcinoma is a Condition, after liver transplantation is a Temporal, Total bilirubin is a Measurement, Immunosuppression is a Procedure, cyclosporine or an mTOR inhibitor ( everolimus or sirolimus ) is a Scope, Severe is a Qualifier, extrahepatic diseases is a Condition, cardiovascular , respiratory , cerebrovascular and poorly controlled diabetes is a Scope, Platelets is a Measurement, Neutrophil count is a Measurement, Hemoglobin is a Measurement, Albumin is a Measurement, HIV infection is a Condition, Hepatitis B infection is a Condition, Active intake is a Temporal, toxic amounts is a Multiplier, alcohol is a Condition, recreational drugs is a Condition, Females who are pregnant , become to be pregnant or breastfeeding is a Scope, males whose partners are pregnant , become to be pregnant or breastfeeding is a Scope, disallowed medications is a Drug, clarithromycin is a Drug, erythromycin is a Drug, telithromycin is a Drug, nafcillin is a Drug, rifampin is a Drug, itraconazole is a Drug, ketoconazole is a Drug, voriconazole is a Drug, nifedipine is a Drug, carbamazepine is a Drug, phenytoin is a Drug, phenobarbital is a Drug, Bosentan is a Drug, Modafinil is a Drug, St . Jonh 's Wort is a Drug, cyclosporin is a Drug, everolimus is a Drug, sirolimus is a Drug, glibenclamide is a Drug, glyburide is a Drug, gemfibrozil is a Drug, Eltrombopag is a Drug, Lapatinib is a Drug, efavirenz is a Drug, etravirine is a Drug, ritonavir boosted and unboosted is a Scope, HIV protease inhibitors is a Drug, simvastatin is a Drug, fluvastatin is a Drug, rosuvastatin is a Drug, doses greater than 10 mg / d is a Multiplier, atorvastatin is a Drug
|
NCT02890719_exc_task1
|
Sentence: Genotype 2, 3, 5 or 6 infection.
Decompensated cirrhosis defined by the presence of actual or previous history of clinical decompensation including ascites, hepatic encephalopathy, variceal bleeding or spontaneous bacterial peritonitis, or a Child-Pugh B or C.
Hepatocellular carcinoma after liver transplantation.
Total bilirubin > 3 mg/dL.
Immunosuppression with cyclosporine or an mTOR inhibitor (everolimus or sirolimus).
Severe extrahepatic diseases: cardiovascular, respiratory, cerebrovascular and poorly controlled diabetes.
Platelets < 75 x 109 cells/L.
Neutrophil count < 0.5 x 109 cells/L.
Hemoglobin < 9 g/dL.
Albumin < 3g/dL.
HIV infection.
Hepatitis B infection.
Active intake of toxic amounts of alcohol or recreational drugs.
Females who are pregnant, become to be pregnant or breastfeeding or males whose partners are pregnant, become to be pregnant or breastfeeding.
Intake of disallowed medications including(but not limited to):
1. Antibiotics: clarithromycin, erythromycin, telithromycin, nafcillin, rifampin
2. Antifungals: itraconazole, ketoconazole, voriconazole
3. Antihypertensives: nifedipine
4. Anticonvulsants: carbamazepine, phenytoin, phenobarbital
5. Bosentan
6. Modafinil
7. St.Jonh's Wort
8. Immunosuppressants: cyclosporin, everolimus, sirolimus
9. Diabetes agents: glibenclamide, glyburide
10. Lipid lowering agents: gemfibrozil
11. Eltrombopag
12. Lapatinib
13. HIV medications: efavirenz, etravirine, all ritonavir boosted and unboosted HIV protease inhibitors
14. Statins: simvastatin, fluvastatin, rosuvastatin at doses greater than 10 mg/d, atorvastatin at doses greater than 10 mg/d.
Instructions: please typing these entity words according to sentence: Genotype, 2 , 3 , 5 or 6, infection, Decompensated, cirrhosis, actual or previous, clinical decompensation, ascites, hepatic encephalopathy, variceal bleeding, spontaneous bacterial peritonitis, Child - Pugh, Hepatocellular carcinoma, after liver transplantation, Total bilirubin, Immunosuppression, cyclosporine or an mTOR inhibitor ( everolimus or sirolimus ), Severe, extrahepatic diseases, cardiovascular , respiratory , cerebrovascular and poorly controlled diabetes, Platelets, Neutrophil count, Hemoglobin, Albumin, HIV infection, Hepatitis B infection, Active intake, toxic amounts, alcohol, recreational drugs, Females who are pregnant , become to be pregnant or breastfeeding, males whose partners are pregnant , become to be pregnant or breastfeeding, disallowed medications, clarithromycin, erythromycin, telithromycin, nafcillin, rifampin, itraconazole, ketoconazole, voriconazole, nifedipine, carbamazepine, phenytoin, phenobarbital, Bosentan, Modafinil, St . Jonh 's Wort, cyclosporin, everolimus, sirolimus, glibenclamide, glyburide, gemfibrozil, Eltrombopag, Lapatinib, efavirenz, etravirine, ritonavir boosted and unboosted, HIV protease inhibitors, simvastatin, fluvastatin, rosuvastatin, doses greater than 10 mg / d, atorvastatin
Options: Temporal, Condition, Qualifier, Value, Multiplier, Procedure, Scope, Measurement, Drug
|
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] |
Genotype 2, 3, 5 or 6 infection.
Decompensated cirrhosis defined by the presence of actual or previous history of clinical decompensation including ascites, hepatic encephalopathy, variceal bleeding or spontaneous bacterial peritonitis, or a Child-Pugh B or C.
Hepatocellular carcinoma after liver transplantation.
Total bilirubin > 3 mg/dL.
Immunosuppression with cyclosporine or an mTOR inhibitor (everolimus or sirolimus).
Severe extrahepatic diseases: cardiovascular, respiratory, cerebrovascular and poorly controlled diabetes.
Platelets < 75 x 109 cells/L.
Neutrophil count < 0.5 x 109 cells/L.
Hemoglobin < 9 g/dL.
Albumin < 3g/dL.
HIV infection.
Hepatitis B infection.
Active intake of toxic amounts of alcohol or recreational drugs.
Females who are pregnant, become to be pregnant or breastfeeding or males whose partners are pregnant, become to be pregnant or breastfeeding.
Intake of disallowed medications including(but not limited to):
1. Antibiotics: clarithromycin, erythromycin, telithromycin, nafcillin, rifampin
2. Antifungals: itraconazole, ketoconazole, voriconazole
3. Antihypertensives: nifedipine
4. Anticonvulsants: carbamazepine, phenytoin, phenobarbital
5. Bosentan
6. Modafinil
7. St.Jonh's Wort
8. Immunosuppressants: cyclosporin, everolimus, sirolimus
9. Diabetes agents: glibenclamide, glyburide
10. Lipid lowering agents: gemfibrozil
11. Eltrombopag
12. Lapatinib
13. HIV medications: efavirenz, etravirine, all ritonavir boosted and unboosted HIV protease inhibitors
14. Statins: simvastatin, fluvastatin, rosuvastatin at doses greater than 10 mg/d, atorvastatin at doses greater than 10 mg/d.
|
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[
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Genotype, 2 , 3 , 5 or 6, infection, Decompensated, cirrhosis, actual or previous, clinical decompensation, ascites, hepatic encephalopathy, variceal bleeding, spontaneous bacterial peritonitis, Child - Pugh, Hepatocellular carcinoma, after liver transplantation, Total bilirubin, Immunosuppression, cyclosporine or an mTOR inhibitor ( everolimus or sirolimus ), Severe, extrahepatic diseases, cardiovascular , respiratory , cerebrovascular and poorly controlled diabetes, Platelets, Neutrophil count, Hemoglobin, Albumin, HIV infection, Hepatitis B infection, Active intake, toxic amounts, alcohol, recreational drugs, Females who are pregnant , become to be pregnant or breastfeeding, males whose partners are pregnant , become to be pregnant or breastfeeding, disallowed medications, clarithromycin, erythromycin, telithromycin, nafcillin, rifampin, itraconazole, ketoconazole, voriconazole, nifedipine, carbamazepine, phenytoin, phenobarbital, Bosentan, Modafinil, St . Jonh 's Wort, cyclosporin, everolimus, sirolimus, glibenclamide, glyburide, gemfibrozil, Eltrombopag, Lapatinib, efavirenz, etravirine, ritonavir boosted and unboosted, HIV protease inhibitors, simvastatin, fluvastatin, rosuvastatin, doses greater than 10 mg / d, atorvastatin
|
NCT02890719_exc_task2
|
Sentence: Genotype 2, 3, 5 or 6 infection.
Decompensated cirrhosis defined by the presence of actual or previous history of clinical decompensation including ascites, hepatic encephalopathy, variceal bleeding or spontaneous bacterial peritonitis, or a Child-Pugh B or C.
Hepatocellular carcinoma after liver transplantation.
Total bilirubin > 3 mg/dL.
Immunosuppression with cyclosporine or an mTOR inhibitor (everolimus or sirolimus).
Severe extrahepatic diseases: cardiovascular, respiratory, cerebrovascular and poorly controlled diabetes.
Platelets < 75 x 109 cells/L.
Neutrophil count < 0.5 x 109 cells/L.
Hemoglobin < 9 g/dL.
Albumin < 3g/dL.
HIV infection.
Hepatitis B infection.
Active intake of toxic amounts of alcohol or recreational drugs.
Females who are pregnant, become to be pregnant or breastfeeding or males whose partners are pregnant, become to be pregnant or breastfeeding.
Intake of disallowed medications including(but not limited to):
1. Antibiotics: clarithromycin, erythromycin, telithromycin, nafcillin, rifampin
2. Antifungals: itraconazole, ketoconazole, voriconazole
3. Antihypertensives: nifedipine
4. Anticonvulsants: carbamazepine, phenytoin, phenobarbital
5. Bosentan
6. Modafinil
7. St.Jonh's Wort
8. Immunosuppressants: cyclosporin, everolimus, sirolimus
9. Diabetes agents: glibenclamide, glyburide
10. Lipid lowering agents: gemfibrozil
11. Eltrombopag
12. Lapatinib
13. HIV medications: efavirenz, etravirine, all ritonavir boosted and unboosted HIV protease inhibitors
14. Statins: simvastatin, fluvastatin, rosuvastatin at doses greater than 10 mg/d, atorvastatin at doses greater than 10 mg/d.
Instructions: please extract entity words from the input sentence
|
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"O",
"O",
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"O",
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"O",
"O",
"B-Scope",
"I-Scope",
"I-Scope",
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"B-Drug",
"I-Drug",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Genotype 2, 3, 5 or 6 infection.
Decompensated cirrhosis defined by the presence of actual or previous history of clinical decompensation including ascites, hepatic encephalopathy, variceal bleeding or spontaneous bacterial peritonitis, or a Child-Pugh B or C.
Hepatocellular carcinoma after liver transplantation.
Total bilirubin > 3 mg/dL.
Immunosuppression with cyclosporine or an mTOR inhibitor (everolimus or sirolimus).
Severe extrahepatic diseases: cardiovascular, respiratory, cerebrovascular and poorly controlled diabetes.
Platelets < 75 x 109 cells/L.
Neutrophil count < 0.5 x 109 cells/L.
Hemoglobin < 9 g/dL.
Albumin < 3g/dL.
HIV infection.
Hepatitis B infection.
Active intake of toxic amounts of alcohol or recreational drugs.
Females who are pregnant, become to be pregnant or breastfeeding or males whose partners are pregnant, become to be pregnant or breastfeeding.
Intake of disallowed medications including(but not limited to):
1. Antibiotics: clarithromycin, erythromycin, telithromycin, nafcillin, rifampin
2. Antifungals: itraconazole, ketoconazole, voriconazole
3. Antihypertensives: nifedipine
4. Anticonvulsants: carbamazepine, phenytoin, phenobarbital
5. Bosentan
6. Modafinil
7. St.Jonh's Wort
8. Immunosuppressants: cyclosporin, everolimus, sirolimus
9. Diabetes agents: glibenclamide, glyburide
10. Lipid lowering agents: gemfibrozil
11. Eltrombopag
12. Lapatinib
13. HIV medications: efavirenz, etravirine, all ritonavir boosted and unboosted HIV protease inhibitors
14. Statins: simvastatin, fluvastatin, rosuvastatin at doses greater than 10 mg/d, atorvastatin at doses greater than 10 mg/d.
|
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",",
"telithromycin",
",",
"nafcillin",
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"rifampin",
"\n",
"2",
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"itraconazole",
",",
"ketoconazole",
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"voriconazole",
"\n",
"3",
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"4",
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"carbamazepine",
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"phenobarbital",
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":",
"glibenclamide",
",",
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"\n",
"10",
".",
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"lowering",
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":",
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"\n",
"11",
".",
"Eltrombopag",
"\n",
"12",
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"Lapatinib",
"\n",
"13",
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"HIV",
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":",
"efavirenz",
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"all",
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"HIV",
"protease",
"inhibitors",
"\n",
"14",
".",
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":",
"simvastatin",
",",
"fluvastatin",
",",
"rosuvastatin",
"at",
"doses",
"greater",
"than",
"10",
"mg",
"/",
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",",
"atorvastatin",
"at",
"doses",
"greater",
"than",
"10",
"mg",
"/",
"d.",
" \n \n"
] |
[
"Scope",
"Condition",
"Temporal",
"Multiplier",
"Drug",
"Procedure",
"Reference_point",
"Value",
"Qualifier",
"Measurement",
"Observation",
"Person"
] |
coffee is a Plant, colorectal cancer is a Disease, coffee is a Plant, colorectal cancer is a Disease, coffee is a Plant, coffee is a Plant, colonic cancer is a Disease, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, colon cancer is a Disease
|
10971235_task0
|
Sentence: BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Disease, Plant
|
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"B-Disease",
"I-Disease",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"B-Disease",
"I-Disease",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"B-Disease",
"I-Disease",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"B-Plant",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Disease",
"I-Disease",
"O",
"O",
"O",
"O",
"O",
"O"
] |
BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
|
[
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"."
] |
[
"Disease",
"Plant"
] |
coffee is a Plant, colorectal cancer is a Disease, coffee is a Plant, colorectal cancer is a Disease, coffee is a Plant, coffee is a Plant, colonic cancer is a Disease, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, coffee is a Plant, colon cancer is a Disease
|
10971235_task1
|
Sentence: BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
Instructions: please typing these entity words according to sentence: coffee, colorectal cancer, coffee, colorectal cancer, coffee, coffee, colonic cancer, coffee, coffee, coffee, coffee, coffee, coffee, colon cancer
Options: Disease, Plant
|
[
"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
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"O",
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"O",
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"O",
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"O",
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"O",
"O",
"O",
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BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
|
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] |
[
"Disease",
"Plant"
] |
coffee, colorectal cancer, coffee, colorectal cancer, coffee, coffee, colonic cancer, coffee, coffee, coffee, coffee, coffee, coffee, colon cancer
|
10971235_task2
|
Sentence: BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
Instructions: please extract entity words from the input sentence
|
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"B-Disease",
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] |
BACKGROUND: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies might be related to the type of coffee brew. OBJECTIVE: We studied the effect of unfiltered coffee consumption on putative biomarkers for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31 men and 33 women), with a mean age of 43 +/- 11 years were randomly assigned to two groups in a crossover design, with two intervention periods of 2 weeks separated by a washout period of 8 weeks. Treatments were 1 L of cafeti re (French press) coffee daily or no coffee. At the end of each intervention period, fasting blood samples, colorectal biopsies and 48 h faeces were collected. RESULTS: No effect of coffee on colorectal cell proliferation, assayed by estimating the Proliferating Cell Nuclear Antigen labelling index, was seen. Additionally, no effects were seen on the concentrations of faecal soluble bile acids and colorectal mucosal glutathione S-transferase activity. However, unfiltered coffee significantly increased the glutathione content in the colorectal mucosa by 8% and in plasma by 15%. Other aminothiols in plasma also increased on coffee. CONCLUSION: Unfiltered coffee does not influence the colorectal mucosal proliferation rate, but might increase the detoxification capacity and anti-mutagenic properties in the colorectal mucosa through an increase in glutathione concentration. Whether this effect indeed contributes to a lower colon cancer risk remains to be established.
|
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] |
[
"Disease",
"Plant"
] |
Pediatric is a Person, deep dental decay is a Condition, primary molars is a Qualifier, Teeth is a Qualifier, reversible pulpitis is a Condition
|
NCT02298504_inc_task0
|
Sentence: Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Person, Condition, Qualifier
|
[
"B-Person",
"O",
"O",
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"I-Condition",
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"O",
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"O",
"O",
"O",
"O",
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"B-Condition",
"I-Condition",
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] |
Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
|
[
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] |
[
"Condition",
"Qualifier",
"Person"
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Pediatric is a Person, deep dental decay is a Condition, primary molars is a Qualifier, Teeth is a Qualifier, reversible pulpitis is a Condition
|
NCT02298504_inc_task1
|
Sentence: Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
Instructions: please typing these entity words according to sentence: Pediatric, deep dental decay, primary molars, Teeth, reversible pulpitis
Options: Person, Condition, Qualifier
|
[
"B-Person",
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"O",
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"I-Condition",
"O"
] |
Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
|
[
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"patients",
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"decay",
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"pulpitis",
"\n"
] |
[
"Condition",
"Qualifier",
"Person"
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Pediatric, deep dental decay, primary molars, Teeth, reversible pulpitis
|
NCT02298504_inc_task2
|
Sentence: Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
Instructions: please extract entity words from the input sentence
|
[
"B-Person",
"O",
"O",
"B-Condition",
"I-Condition",
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"O",
"B-Qualifier",
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"O",
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"O",
"O",
"O",
"O",
"O",
"B-Condition",
"I-Condition",
"O"
] |
Pediatric patients with deep dental decay in primary molars
Teeth with signs and symptoms of reversible pulpitis
|
[
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] |
[
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prescription of is an umlsterm, general practitioners is an umlsterm, treatment is an umlsterm, pain is an umlsterm, prescriptions of is an umlsterm, opioids is an umlsterm, doctors is an umlsterm, patients is an umlsterm, patients is an umlsterm, prescription is an umlsterm, prescriptions is an umlsterm, patients is an umlsterm, prescriptions is an umlsterm, opioids is an umlsterm, cancer is an umlsterm, pain is an umlsterm, consumption is an umlsterm, morphine is an umlsterm, narcotics is an umlsterm, pain is an umlsterm, treatment is an umlsterm, general practitioners is an umlsterm, pain is an umlsterm, treatment is an umlsterm, value is an umlsterm, opioids is an umlsterm, patients is an umlsterm, physicians is an umlsterm, contrast is an umlsterm, prescription of is an umlsterm, levomethadone is an umlsterm, therapy is an umlsterm, patients is an umlsterm, physicians is an umlsterm, methadone is an umlsterm, therapy is an umlsterm, opioids is an umlsterm, prescriptions is an umlsterm, physicians is an umlsterm, pain is an umlsterm, treatment is an umlsterm, care is an umlsterm, pain is an umlsterm, treatment is an umlsterm, opioid analgesics is an umlsterm, training is an umlsterm, physicians is an umlsterm, narcotics is an umlsterm, narcotic is an umlsterm, prescription is an umlsterm, terminology is an umlsterm, pharmacology - related is an umlsterm, analgesic is an umlsterm, prescription is an umlsterm, regulations is an umlsterm, treatment is an umlsterm, prescription of is an umlsterm, opioids is an umlsterm
|
DerSchmerz.60100292.eng.abstr_task0
|
Sentence: The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
|
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[
"umlsterm"
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|
DerSchmerz.60100292.eng.abstr_task1
|
Sentence: The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
Instructions: please typing these entity words according to sentence: prescription of, general practitioners, treatment, pain, prescriptions of, opioids, doctors, patients, patients, prescription, prescriptions, patients, prescriptions, opioids, cancer, pain, consumption, morphine, narcotics, pain, treatment, general practitioners, pain, treatment, value, opioids, patients, physicians, contrast, prescription of, levomethadone, therapy, patients, physicians, methadone, therapy, opioids, prescriptions, physicians, pain, treatment, care, pain, treatment, opioid analgesics, training, physicians, narcotics, narcotic, prescription, terminology, pharmacology - related, analgesic, prescription, regulations, treatment, prescription of, opioids
Options: umlsterm
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The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
|
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[
"umlsterm"
] |
prescription of, general practitioners, treatment, pain, prescriptions of, opioids, doctors, patients, patients, prescription, prescriptions, patients, prescriptions, opioids, cancer, pain, consumption, morphine, narcotics, pain, treatment, general practitioners, pain, treatment, value, opioids, patients, physicians, contrast, prescription of, levomethadone, therapy, patients, physicians, methadone, therapy, opioids, prescriptions, physicians, pain, treatment, care, pain, treatment, opioid analgesics, training, physicians, narcotics, narcotic, prescription, terminology, pharmacology - related, analgesic, prescription, regulations, treatment, prescription of, opioids
|
DerSchmerz.60100292.eng.abstr_task2
|
Sentence: The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
Instructions: please extract entity words from the input sentence
|
[
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The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression " narcotic prescription " be changed related to the legislative terminology in the pharmacology-related expression " analgesic prescription " . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids .
|
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] |
[
"umlsterm"
] |
Literatur is an umlsterm, Tumors is an umlsterm, Rezidiven is an umlsterm, Kindes- is an umlsterm, Erwachsenenalters is an umlsterm, namensgebende is an umlsterm, Riesenzellen is an umlsterm, Neoplasie is an umlsterm
|
DerPathologe.40150049.ger.abstr_task0
|
Sentence: Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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"O",
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Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
|
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[
"umlsterm"
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Literatur is an umlsterm, Tumors is an umlsterm, Rezidiven is an umlsterm, Kindes- is an umlsterm, Erwachsenenalters is an umlsterm, namensgebende is an umlsterm, Riesenzellen is an umlsterm, Neoplasie is an umlsterm
|
DerPathologe.40150049.ger.abstr_task1
|
Sentence: Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
Instructions: please typing these entity words according to sentence: Literatur, Tumors, Rezidiven, Kindes-, Erwachsenenalters, namensgebende, Riesenzellen, Neoplasie
Options: umlsterm
|
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"O",
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Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
|
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[
"umlsterm"
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Literatur, Tumors, Rezidiven, Kindes-, Erwachsenenalters, namensgebende, Riesenzellen, Neoplasie
|
DerPathologe.40150049.ger.abstr_task2
|
Sentence: Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
Instructions: please extract entity words from the input sentence
|
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Zusammenfassung . Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors ( PFT ) . Diagnostische Kriterien dieser seltenen , vornehmlich subkutan lokalisierten und zu Rezidiven neigenden , insgesamt aber prognostisch guenstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp . Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Haemangioperizytoms weist auf die Moeglichkeit einer Strahleninduktion des PFT hin .
|
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[
"umlsterm"
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hereditary non - polyposis colon cancer is a disease, Hereditary non - polyposis colon cancer is a disease, HNPCC is a disease, autosomal dominant is a Concepts_Ideas, early development is a Disorder, cancers is a disease, colon is a body-part, rectum is a body-part, endometrium is a body-part, ovarium is a body-part, small bowel is a body-part, stomach is a body-part, urinary tract is a body-part, HNPCC is a disease, germline mutations in the DNA mismatch repair genes is a mutation, hMSH2 is a gene, hMLH1 is a gene, three is a size, first - degree relatives is a cohort-patient, mother is a gender, two is a size, sisters is a cohort-patient, male is a cohort-patient, colorectal is a body-part, adenocarcinoma is a disease, age of 23 is an age, family is a cohort-patient, extracolonic is a body-part, tumors is a disease, proband is a cohort-patient, his is a gender, Tumor is a disease, HNPCC is a disease, hMLH1 is a gene, hMSH2 is a gene, proband 's is a cohort-patient, tumor is a disease, his is a gender, tumor is a disease, high frequency microsatellite instability is a Disorder, MSI - H is a Disorder, HNPCC is a disease, family is a cohort-patient, missense ( c.1864C > A ) mutation in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, tumor is a disease
|
43_task0
|
Sentence: ** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: size, Concepts_Ideas, disease, cohort-patient, body-part, gender, Disorder, mutation, gene, age
|
[
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] |
** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
|
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[
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"Disorder",
"disease",
"cohort-patient",
"Concepts_Ideas",
"body-part",
"age",
"gender",
"size",
"gene"
] |
hereditary non - polyposis colon cancer is a disease, Hereditary non - polyposis colon cancer is a disease, HNPCC is a disease, autosomal dominant is a Concepts_Ideas, early development is a Disorder, cancers is a disease, colon is a body-part, rectum is a body-part, endometrium is a body-part, ovarium is a body-part, small bowel is a body-part, stomach is a body-part, urinary tract is a body-part, HNPCC is a disease, germline mutations in the DNA mismatch repair genes is a mutation, hMSH2 is a gene, hMLH1 is a gene, three is a size, first - degree relatives is a cohort-patient, mother is a gender, two is a size, sisters is a cohort-patient, male is a cohort-patient, colorectal is a body-part, adenocarcinoma is a disease, age of 23 is an age, family is a cohort-patient, extracolonic is a body-part, tumors is a disease, proband is a cohort-patient, his is a gender, Tumor is a disease, HNPCC is a disease, hMLH1 is a gene, hMSH2 is a gene, proband 's is a cohort-patient, tumor is a disease, his is a gender, tumor is a disease, high frequency microsatellite instability is a Disorder, MSI - H is a Disorder, HNPCC is a disease, family is a cohort-patient, missense ( c.1864C > A ) mutation in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, tumor is a disease
|
43_task1
|
Sentence: ** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
Instructions: please typing these entity words according to sentence: hereditary non - polyposis colon cancer, Hereditary non - polyposis colon cancer, HNPCC, autosomal dominant, early development, cancers, colon, rectum, endometrium, ovarium, small bowel, stomach, urinary tract, HNPCC, germline mutations in the DNA mismatch repair genes, hMSH2, hMLH1, three, first - degree relatives, mother, two, sisters, male, colorectal, adenocarcinoma, age of 23, family, extracolonic, tumors, proband, his, Tumor, HNPCC, hMLH1, hMSH2, proband 's, tumor, his, tumor, high frequency microsatellite instability, MSI - H, HNPCC, family, missense ( c.1864C > A ) mutation in exon 12, hMSH2, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution, tumor
Options: size, Concepts_Ideas, disease, cohort-patient, body-part, gender, Disorder, mutation, gene, age
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-disease",
"I-disease",
"I-disease",
"I-disease",
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** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
|
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] |
[
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"cohort-patient",
"Concepts_Ideas",
"body-part",
"age",
"gender",
"size",
"gene"
] |
hereditary non - polyposis colon cancer, Hereditary non - polyposis colon cancer, HNPCC, autosomal dominant, early development, cancers, colon, rectum, endometrium, ovarium, small bowel, stomach, urinary tract, HNPCC, germline mutations in the DNA mismatch repair genes, hMSH2, hMLH1, three, first - degree relatives, mother, two, sisters, male, colorectal, adenocarcinoma, age of 23, family, extracolonic, tumors, proband, his, Tumor, HNPCC, hMLH1, hMSH2, proband 's, tumor, his, tumor, high frequency microsatellite instability, MSI - H, HNPCC, family, missense ( c.1864C > A ) mutation in exon 12, hMSH2, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution, tumor
|
43_task2
|
Sentence: ** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
Instructions: please extract entity words from the input sentence
|
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** IGNORE LINE **
** IGNORE LINE **
** IGNORE LINE **
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue
Abstract
Background
Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1.
In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I) with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors.
Methods
Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250). Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed.
Results
Three of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H). We identified in the HNPCC family a novel germline missense (c.1864C>A) mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution.
Conclusion
This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD) and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) Database this is the first report of this mutation.
|
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Txnip is a GENE-Y
|
23584857_task0
|
Sentence: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: GENE-Y
|
[
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Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
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Txnip is a GENE-Y
|
23584857_task1
|
Sentence: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
Instructions: please typing these entity words according to sentence: Txnip
Options: GENE-Y
|
[
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Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
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Txnip
|
23584857_task2
|
Sentence: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
Instructions: please extract entity words from the input sentence
|
[
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Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
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[
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CD4 is a Protein, CDR2-loop is a Entity, extracellular domain 1 is a Entity, CD4 is a Protein, gp120-anti - gp120 immune complexes is a Entity, NF - kappaB is a Entity, CD4 is a Protein, NF - kappaB is a Entity, CDR2-loop is a Entity, domain 1 is a Entity, D1 is a Entity, CD4 is a Protein, CD4 is a Protein, CD4 is a Protein, D1 is a Entity, D1 / CDR3-loop is a Entity, CD4 is a Protein, CD4 is a Protein, D1 / CDR2-loop is a Entity
|
468_task0
|
Sentence: HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Entity, Protein
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HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
|
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[
"Entity",
"Protein"
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CD4 is a Protein, CDR2-loop is a Entity, extracellular domain 1 is a Entity, CD4 is a Protein, gp120-anti - gp120 immune complexes is a Entity, NF - kappaB is a Entity, CD4 is a Protein, NF - kappaB is a Entity, CDR2-loop is a Entity, domain 1 is a Entity, D1 is a Entity, CD4 is a Protein, CD4 is a Protein, CD4 is a Protein, D1 is a Entity, D1 / CDR3-loop is a Entity, CD4 is a Protein, CD4 is a Protein, D1 / CDR2-loop is a Entity
|
468_task1
|
Sentence: HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
Instructions: please typing these entity words according to sentence: CD4, CDR2-loop, extracellular domain 1, CD4, gp120-anti - gp120 immune complexes, NF - kappaB, CD4, NF - kappaB, CDR2-loop, domain 1, D1, CD4, CD4, CD4, D1, D1 / CDR3-loop, CD4, CD4, D1 / CDR2-loop
Options: Entity, Protein
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HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
|
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[
"Entity",
"Protein"
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CD4, CDR2-loop, extracellular domain 1, CD4, gp120-anti - gp120 immune complexes, NF - kappaB, CD4, NF - kappaB, CDR2-loop, domain 1, D1, CD4, CD4, CD4, D1, D1 / CDR3-loop, CD4, CD4, D1 / CDR2-loop
|
468_task2
|
Sentence: HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
Instructions: please extract entity words from the input sentence
|
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HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9). In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli. Moreover, we further investigated the physiologic relevance of these observations. When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus. This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs. Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies). In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop. Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands. Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
|
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[
"Entity",
"Protein"
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Hyperforin is a Drug_or_compound, neutrophil is a Cell, matrix metalloproteinase-9 is a Gene_or_gene_product, lung is a Organ, Hyperforin is a Drug_or_compound, Hyp is a Drug_or_compound, John 's wort is a Organism, Hypericum perforatum is a Organism, lymphocyte is a Cell, tumor cell is a Cell, matrix proteinases is a Gene_or_gene_product, leukocyte elastase is a Gene_or_gene_product, LE is a Gene_or_gene_product, Hyp is a Drug_or_compound, polymorphonuclear neutrophil ( PMN ) leukocyte is a Cell, tissue is a Tissue, human is a Organism, PMN is a Cell, Hyp is a Drug_or_compound, dicyclohexylammonium salt is a Drug_or_compound, CD11b is a Gene_or_gene_product, formyl - Met - Leu - Phe is a Drug_or_compound, neutrophils is a Cell, LE is a Gene_or_gene_product, gelatinase matrix metalloproteinase-9 is a Gene_or_gene_product, PMN is a Cell, Hyp is a Drug_or_compound, murine is a Organism, Hyp is a Drug_or_compound, PMN is a Cell, bleomycin is a Drug_or_compound, Hyp is a Drug_or_compound
|
31_task0
|
Sentence: Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Tissue, Organ, Organism, Drug_or_compound, Gene_or_gene_product, Cell
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Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
|
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|
31_task1
|
Sentence: Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
Instructions: please typing these entity words according to sentence: Hyperforin, neutrophil, matrix metalloproteinase-9, lung, Hyperforin, Hyp, John 's wort, Hypericum perforatum, lymphocyte, tumor cell, matrix proteinases, leukocyte elastase, LE, Hyp, polymorphonuclear neutrophil ( PMN ) leukocyte, tissue, human, PMN, Hyp, dicyclohexylammonium salt, CD11b, formyl - Met - Leu - Phe, neutrophils, LE, gelatinase matrix metalloproteinase-9, PMN, Hyp, murine, Hyp, PMN, bleomycin, Hyp
Options: Tissue, Organ, Organism, Drug_or_compound, Gene_or_gene_product, Cell
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Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
|
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Hyperforin, neutrophil, matrix metalloproteinase-9, lung, Hyperforin, Hyp, John 's wort, Hypericum perforatum, lymphocyte, tumor cell, matrix proteinases, leukocyte elastase, LE, Hyp, polymorphonuclear neutrophil ( PMN ) leukocyte, tissue, human, PMN, Hyp, dicyclohexylammonium salt, CD11b, formyl - Met - Leu - Phe, neutrophils, LE, gelatinase matrix metalloproteinase-9, PMN, Hyp, murine, Hyp, PMN, bleomycin, Hyp
|
31_task2
|
Sentence: Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
Instructions: please extract entity words from the input sentence
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Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of the plant but also as an inhibitor of bacteria lymphocyte and tumor cell proliferation, and matrix proteinases. We tested whether as well as inhibiting leukocyte elastase (LE) activity, Hyp might be effective in containing both polymorphonuclear neutrophil (PMN) leukocyte recruitment and unfavorable eventual tissue responses. The results show that, without affecting in vitro human PMN viability and chemokine-receptor expression, Hyp (as stable dicyclohexylammonium salt) was able to inhibit in a dose-dependent manner their chemotaxis and chemoinvasion (IC50=1 microM for both); this effect was associated with a reduced expression of the adhesion molecule CD11b by formyl-Met-Leu-Phe-stimulated neutrophils and block of LE-triggered activation of the gelatinase matrix metalloproteinase-9. PMN-triggered angiogenesis is also blocked by both local injection and daily i.p. administration of the Hyp salt in an interleukin-8-induced murine model. Furthermore, i.p. treatment with Hyp reduces acute PMN recruitment and enhances resolution in a pulmonary bleomycin-induced inflammation model, significantly reducing consequent fibrosis. These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys.
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Abstract is an umlsterm, United States is an umlsterm, America is an umlsterm, Canada is an umlsterm, Germany is an umlsterm, recommendations is an umlsterm, procedures is an umlsterm, EPP is an umlsterm, persons is an umlsterm, virus is an umlsterm, HBV is an umlsterm, virus is an umlsterm, HCV is an umlsterm, HIV is an umlsterm, review is an umlsterm, EPP is an umlsterm, methods is an umlsterm, transmission is an umlsterm, blood - borne pathogens is an umlsterm, immunisation is an umlsterm, screening is an umlsterm, policies is an umlsterm, constitution is an umlsterm, regulations is an umlsterm
|
DerChirurg.00710396.eng.abstr_task0
|
Sentence: Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
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|
DerChirurg.00710396.eng.abstr_task1
|
Sentence: Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
Instructions: please typing these entity words according to sentence: Abstract, United States, America, Canada, Germany, recommendations, procedures, EPP, persons, virus, HBV, virus, HCV, HIV, review, EPP, methods, transmission, blood - borne pathogens, immunisation, screening, policies, constitution, regulations
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Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
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Abstract, United States, America, Canada, Germany, recommendations, procedures, EPP, persons, virus, HBV, virus, HCV, HIV, review, EPP, methods, transmission, blood - borne pathogens, immunisation, screening, policies, constitution, regulations
|
DerChirurg.00710396.eng.abstr_task2
|
Sentence: Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
Instructions: please extract entity words from the input sentence
|
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"I-umlsterm",
"I-umlsterm",
"I-umlsterm",
"O",
"B-umlsterm",
"O",
"B-umlsterm",
"B-umlsterm",
"O",
"B-umlsterm",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O"
] |
Abstract . In the United States of America ( 1991 ) , in Canada ( 1998 ) , in the UK ( 1993 , 1994 ) and in Germany ( 1999 ) recommendations have been published concerning performance of " exposure-prone procedures " ( EPP ) by persons infected with Hepatitis-B virus ( HBV ) , Hepatitis-C virus ( HCV ) or HIV . This review summarises the definition of EPP , methods to reduce the transmission of blood-borne pathogens , immunisation and screening policies , constitution of an advisory panel and the question of trace-back investigations described in these regulations .
|
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] |
[
"umlsterm"
] |
CCK is a GENE-Y, 5-HT receptor is a GENE-N
|
10517265_task0
|
Sentence: CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: GENE-Y, GENE-N
|
[
"B-GENE-Y",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-GENE-N",
"I-GENE-N",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
|
[
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"-",
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[
"CHEMICAL",
"GENE-N",
"GENE-Y"
] |
CCK is a GENE-Y, 5-HT receptor is a GENE-N
|
10517265_task1
|
Sentence: CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
Instructions: please typing these entity words according to sentence: CCK, 5-HT receptor
Options: GENE-Y, GENE-N
|
[
"B-GENE-Y",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-GENE-N",
"I-GENE-N",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
|
[
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[
"CHEMICAL",
"GENE-N",
"GENE-Y"
] |
CCK, 5-HT receptor
|
10517265_task2
|
Sentence: CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
Instructions: please extract entity words from the input sentence
|
[
"B-GENE-Y",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-GENE-N",
"I-GENE-N",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.
|
[
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[
"CHEMICAL",
"GENE-N",
"GENE-Y"
] |
Brevibacterium linens is a Microorganism, farmhouse cheeses is a Habitat, Brevibacterium spp . is a Microorganism, cheese from the industrial dairy is a Habitat
|
105_task0
|
Sentence: These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Microorganism, Habitat
|
[
"O",
"O",
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"O",
"O",
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"B-Microorganism",
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"I-Habitat",
"I-Habitat",
"I-Habitat",
"O"
] |
These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
|
[
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[
"Habitat",
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Brevibacterium linens is a Microorganism, farmhouse cheeses is a Habitat, Brevibacterium spp . is a Microorganism, cheese from the industrial dairy is a Habitat
|
105_task1
|
Sentence: These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
Instructions: please typing these entity words according to sentence: Brevibacterium linens, farmhouse cheeses, Brevibacterium spp ., cheese from the industrial dairy
Options: Microorganism, Habitat
|
[
"O",
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"B-Microorganism",
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"B-Habitat",
"I-Habitat",
"O",
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"O",
"O",
"B-Habitat",
"I-Habitat",
"I-Habitat",
"I-Habitat",
"I-Habitat",
"O"
] |
These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
|
[
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[
"Habitat",
"Microorganism"
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Brevibacterium linens, farmhouse cheeses, Brevibacterium spp ., cheese from the industrial dairy
|
105_task2
|
Sentence: These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
Instructions: please extract entity words from the input sentence
|
[
"O",
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"B-Microorganism",
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"O",
"O",
"B-Habitat",
"I-Habitat",
"I-Habitat",
"I-Habitat",
"I-Habitat",
"O"
] |
These observations were confirmed in the present study as Brevibacterium linens was found to be subdominant compared to other bacteria on the farmhouse cheeses, and no Brevibacterium spp. was found on the cheese from the industrial dairy.
|
[
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[
"Habitat",
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supplementation is an umlsterm, treatment is an umlsterm, osteoporosis is an umlsterm, aim is an umlsterm, alfacalcidol is an umlsterm, vitamin D is an umlsterm, patients is an umlsterm, vertebral fractures is an umlsterm, Patients is an umlsterm, glucocorticoid - therapy is an umlsterm, alfacalcidol is an umlsterm, calcium is an umlsterm, vitamin D is an umlsterm, calcium is an umlsterm, age is an umlsterm, sex distribution is an umlsterm, diseases is an umlsterm, bone mineral density is an umlsterm, values is an umlsterm, spine is an umlsterm, neck is an umlsterm, fractures is an umlsterm, treatment is an umlsterm, spine is an umlsterm, vertebral fractures is an umlsterm, patients is an umlsterm, patients is an umlsterm, back pain is an umlsterm, alfacalcidol is an umlsterm, treatment is an umlsterm, vitamin D is an umlsterm
|
ZfuerRheumatologie.00590176.eng.abstr_task0
|
Sentence: Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
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] |
Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
|
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] |
[
"umlsterm"
] |
supplementation is an umlsterm, treatment is an umlsterm, osteoporosis is an umlsterm, aim is an umlsterm, alfacalcidol is an umlsterm, vitamin D is an umlsterm, patients is an umlsterm, vertebral fractures is an umlsterm, Patients is an umlsterm, glucocorticoid - therapy is an umlsterm, alfacalcidol is an umlsterm, calcium is an umlsterm, vitamin D is an umlsterm, calcium is an umlsterm, age is an umlsterm, sex distribution is an umlsterm, diseases is an umlsterm, bone mineral density is an umlsterm, values is an umlsterm, spine is an umlsterm, neck is an umlsterm, fractures is an umlsterm, treatment is an umlsterm, spine is an umlsterm, vertebral fractures is an umlsterm, patients is an umlsterm, patients is an umlsterm, back pain is an umlsterm, alfacalcidol is an umlsterm, treatment is an umlsterm, vitamin D is an umlsterm
|
ZfuerRheumatologie.00590176.eng.abstr_task1
|
Sentence: Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
Instructions: please typing these entity words according to sentence: supplementation, treatment, osteoporosis, aim, alfacalcidol, vitamin D, patients, vertebral fractures, Patients, glucocorticoid - therapy, alfacalcidol, calcium, vitamin D, calcium, age, sex distribution, diseases, bone mineral density, values, spine, neck, fractures, treatment, spine, vertebral fractures, patients, patients, back pain, alfacalcidol, treatment, vitamin D
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Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
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[
"umlsterm"
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|
ZfuerRheumatologie.00590176.eng.abstr_task2
|
Sentence: Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
Instructions: please extract entity words from the input sentence
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Calcium/vitamin D supplementation is generally used as a first step treatment of glucocorticoid-induced osteoporosis ( GIOP ) . The aim of this trial was to compare the efficacy of the D-hormone alfacalcidol with plain vitamin D in patients with established GIOP with or without vertebral fractures . Patients on long-term glucocorticoid-therapy were treated either with 1µg alfacalcidol plus 5000mg calcium ( group A : n=43) or with 1000 IU vitamin D plus 500mg calcium ( group B : n=42). The two groups were not different in respect to initial characteristics such as age , sex distribution , concomittant diseases , bone mineral density ( mean T-score values at lumbar spine and femoral neck : -3 . 29 and -3 . 25 resp. ) , and in the number of prevalent vertebral and non-vertebral fractures . During the 3 years of treatment we found a significant increase in lumbar spine density in group A ( +2 . 0% , p 0.0001 ) , while no significant changes could be documented in group B at both measuring sites . After 3 years 12 new vertebral fractures had occurred in 10 patients of group A and 21 in 17 patients in group B ( ns ) . Correspondingly we registered a significant decrease of back pain only in group A ( p 0.0001 ) . We conclude that alfacalcidol treatment in superior to plain vitamin D in GIOP .
|
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[
"umlsterm"
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review is an umlsterm, research is an umlsterm, development is an umlsterm, old is an umlsterm, age is an umlsterm, personality development is an umlsterm, old is an umlsterm, age is an umlsterm, old is an umlsterm, age is an umlsterm, research is an umlsterm, competence is an umlsterm, old is an umlsterm, age is an umlsterm, Independence is an umlsterm, life is an umlsterm, competence is an umlsterm, environments is an umlsterm, health is an umlsterm, death is an umlsterm, findings is an umlsterm, survey is an umlsterm
|
ZfuerGerontologie+Geriatrie.90320456.eng.abstr_task0
|
Sentence: In this four-part review article , an update covering the gero-psychological research since 1988 in German speaking countries is given as follows : Cognitive development in old age ( part I ) , personality development in old age ( part II ) , social relations in old age ( part III ) , age-related tasks , burdens , and border situations ( part IV ) . In part IV of the update presented in this issue , research contributing to a competence perspective of old age and aging is summarized under four main headings : ( 1 ) Independence , everyday life , and everyday competence ; ( 2 ) aging in spatial , physical , and technical environments ; ( 3 ) health and coping with illness ; ( 4 ) coping with death and dying . The article ends with a general discussion considering as well the findings of our survey addressing gerontologists from German speaking countries .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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ZfuerGerontologie+Geriatrie.90320456.eng.abstr_task1
|
Sentence: In this four-part review article , an update covering the gero-psychological research since 1988 in German speaking countries is given as follows : Cognitive development in old age ( part I ) , personality development in old age ( part II ) , social relations in old age ( part III ) , age-related tasks , burdens , and border situations ( part IV ) . In part IV of the update presented in this issue , research contributing to a competence perspective of old age and aging is summarized under four main headings : ( 1 ) Independence , everyday life , and everyday competence ; ( 2 ) aging in spatial , physical , and technical environments ; ( 3 ) health and coping with illness ; ( 4 ) coping with death and dying . The article ends with a general discussion considering as well the findings of our survey addressing gerontologists from German speaking countries .
Instructions: please typing these entity words according to sentence: review, research, development, old, age, personality development, old, age, old, age, research, competence, old, age, Independence, life, competence, environments, health, death, findings, survey
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In this four-part review article , an update covering the gero-psychological research since 1988 in German speaking countries is given as follows : Cognitive development in old age ( part I ) , personality development in old age ( part II ) , social relations in old age ( part III ) , age-related tasks , burdens , and border situations ( part IV ) . In part IV of the update presented in this issue , research contributing to a competence perspective of old age and aging is summarized under four main headings : ( 1 ) Independence , everyday life , and everyday competence ; ( 2 ) aging in spatial , physical , and technical environments ; ( 3 ) health and coping with illness ; ( 4 ) coping with death and dying . The article ends with a general discussion considering as well the findings of our survey addressing gerontologists from German speaking countries .
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ZfuerGerontologie+Geriatrie.90320456.eng.abstr_task2
|
Sentence: In this four-part review article , an update covering the gero-psychological research since 1988 in German speaking countries is given as follows : Cognitive development in old age ( part I ) , personality development in old age ( part II ) , social relations in old age ( part III ) , age-related tasks , burdens , and border situations ( part IV ) . In part IV of the update presented in this issue , research contributing to a competence perspective of old age and aging is summarized under four main headings : ( 1 ) Independence , everyday life , and everyday competence ; ( 2 ) aging in spatial , physical , and technical environments ; ( 3 ) health and coping with illness ; ( 4 ) coping with death and dying . The article ends with a general discussion considering as well the findings of our survey addressing gerontologists from German speaking countries .
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|
Glycopyrrolate_ddi_task0
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Sentence: The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects. Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
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Glycopyrrolate_ddi_task1
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Sentence: The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects. Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.
Instructions: please typing these entity words according to sentence: Robinul, anticholinergics, phenothiazines, antiparkinson drugs, tricyclic antidepressants, Robinul, potassium chloride
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[
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Robinul, anticholinergics, phenothiazines, antiparkinson drugs, tricyclic antidepressants, Robinul, potassium chloride
|
Glycopyrrolate_ddi_task2
|
Sentence: The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects. Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.
Instructions: please extract entity words from the input sentence
|
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The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects. Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.
|
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|
DerAnaesthesist.40430283.eng.abstr_task0
|
Sentence: The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
|
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[
"umlsterm"
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classification is an umlsterm, neuromuscular diseases is an umlsterm, use is an umlsterm, muscle is an umlsterm, abnormality is an umlsterm, syndromes is an umlsterm, denervation is an umlsterm, transmission is an umlsterm, disease is an umlsterm, Succinylcholine is an umlsterm, denervation is an umlsterm, syndrome is an umlsterm, hyperkalaemia is an umlsterm, time is an umlsterm, succinylcholine is an umlsterm, denervation is an umlsterm, exact is an umlsterm, period is an umlsterm, risk is an umlsterm, Patients is an umlsterm, sensitivity is an umlsterm, non - depolarising muscle relaxants is an umlsterm, motoneuron is an umlsterm, amyotrophic lateral sclerosis is an umlsterm, diseases is an umlsterm, motoneuron is an umlsterm, cerebral apoplexy is an umlsterm, muscle is an umlsterm, diseases is an umlsterm, neuromuscular junction is an umlsterm, myasthenia gravis is an umlsterm, sensitivity is an umlsterm, non - depolarising muscle relaxants is an umlsterm, complications is an umlsterm, use is an umlsterm, succinylcholine is an umlsterm, patients is an umlsterm, use is an umlsterm, succinylcholine is an umlsterm, Patients is an umlsterm, myopathy is an umlsterm, sensitivity is an umlsterm, non - depolarising muscle relaxants is an umlsterm, use is an umlsterm, drugs is an umlsterm, acetylcholine - like is an umlsterm, succinylcholine is an umlsterm, muscle spasms is an umlsterm, patients is an umlsterm, disease is an umlsterm, risk of is an umlsterm, rhabdomyolysis is an umlsterm, patients is an umlsterm, muscle disease is an umlsterm, muscle disease is an umlsterm, titration is an umlsterm, muscle is an umlsterm, nerve is an umlsterm, disease is an umlsterm, muscle is an umlsterm, choice is an umlsterm, atracurium is an umlsterm, vecuronium is an umlsterm, neuromuscular blockade is an umlsterm, patients is an umlsterm, sensitivity is an umlsterm, non - depolarising muscle relaxants is an umlsterm, ventilation is an umlsterm
|
DerAnaesthesist.40430283.eng.abstr_task1
|
Sentence: The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
Instructions: please typing these entity words according to sentence: classification, neuromuscular diseases, use, muscle, abnormality, syndromes, denervation, transmission, disease, Succinylcholine, denervation, syndrome, hyperkalaemia, time, succinylcholine, denervation, exact, period, risk, Patients, sensitivity, non - depolarising muscle relaxants, motoneuron, amyotrophic lateral sclerosis, diseases, motoneuron, cerebral apoplexy, muscle, diseases, neuromuscular junction, myasthenia gravis, sensitivity, non - depolarising muscle relaxants, complications, use, succinylcholine, patients, use, succinylcholine, Patients, myopathy, sensitivity, non - depolarising muscle relaxants, use, drugs, acetylcholine - like, succinylcholine, muscle spasms, patients, disease, risk of, rhabdomyolysis, patients, muscle disease, muscle disease, titration, muscle, nerve, disease, muscle, choice, atracurium, vecuronium, neuromuscular blockade, patients, sensitivity, non - depolarising muscle relaxants, ventilation
Options: umlsterm
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The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
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[
"umlsterm"
] |
classification, neuromuscular diseases, use, muscle, abnormality, syndromes, denervation, transmission, disease, Succinylcholine, denervation, syndrome, hyperkalaemia, time, succinylcholine, denervation, exact, period, risk, Patients, sensitivity, non - depolarising muscle relaxants, motoneuron, amyotrophic lateral sclerosis, diseases, motoneuron, cerebral apoplexy, muscle, diseases, neuromuscular junction, myasthenia gravis, sensitivity, non - depolarising muscle relaxants, complications, use, succinylcholine, patients, use, succinylcholine, Patients, myopathy, sensitivity, non - depolarising muscle relaxants, use, drugs, acetylcholine - like, succinylcholine, muscle spasms, patients, disease, risk of, rhabdomyolysis, patients, muscle disease, muscle disease, titration, muscle, nerve, disease, muscle, choice, atracurium, vecuronium, neuromuscular blockade, patients, sensitivity, non - depolarising muscle relaxants, ventilation
|
DerAnaesthesist.40430283.eng.abstr_task2
|
Sentence: The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
Instructions: please extract entity words from the input sentence
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The classification of neuromuscular diseases with regard to the use of muscle relaxants is based on the localisation of the particular abnormality . Three types of syndromes can be differentiated : ( 1 ) denervation states ; ( 2 ) disturbances of neuromuscular transmission ; and ( 3 ) intracellular disease . Succinylcholine should be avoided in all types of denervation syndrome due to the possibility of life-threatening hyperkalaemia . The time frame during which succinylcholine must be avoided following a traumatic denervation or burn begins 24 h after the event . The exact period of risk is unknown , but a duration of 6 months can be considered the absolute minimum . Patients may display increased sensitivity to non-depolarising muscle relaxants following damage to the second motoneuron ( e.g. , amyotrophic lateral sclerosis ) , whereas in diseases of the first motoneuron ( e.g. , cerebral apoplexy ) , increased resistance to muscle relaxants may be observed in the affected parts of the body . In diseases of the neuromuscular junction ( myasthenia gravis ) there is increased sensitivity to non-depolarising muscle relaxants . No complications have been described following the use of succinylcholine in these patients , however , the use of reversal agents may lead to prolongation of the effect of succinylcholine . Patients with a primary myopathy may display increased sensitivity to non-depolarising muscle relaxants . The use of drugs with acetylcholine-like actions ( succinylcholine , reversal agents ) should be avoided due to the danger of triggering muscle spasms in patients with myotonic disease and the risk of rhabdomyolysis in patients with dystrophic muscle disease . Irrespective of the type of muscle disease present , titration of the dose of muscle relaxant should always be done using a nerve stimulator . The doses required do not correlate with the clinical manifestations of the disease . The muscle relaxants of choice are those non-depolarising agents with the shortest possible duration of action , at present either atracurium or vecuronium . Reversal of prolonged neuromuscular blockade in patients with increased sensitivity to non-depolarising muscle relaxants should be avoided , and controlled ventilation should be continued until spontaneous recovery has occurred .
|
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[
"umlsterm"
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TbPRMT5 is a Protein, TbPRMT5 is a Protein, PRMT5 is a Protein, Skb1 is a Protein, TbPRMT5 is a Protein, RBP16 is a Protein, TbPRMT5 is a Protein, TbPRMT5 is a Protein, TbPRMT5 is a Protein, Ded1 is a Protein, TbPRMT5 is a Protein
|
245_task0
|
Sentence: Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
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Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
|
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[
"Protein"
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TbPRMT5 is a Protein, TbPRMT5 is a Protein, PRMT5 is a Protein, Skb1 is a Protein, TbPRMT5 is a Protein, RBP16 is a Protein, TbPRMT5 is a Protein, TbPRMT5 is a Protein, TbPRMT5 is a Protein, Ded1 is a Protein, TbPRMT5 is a Protein
|
245_task1
|
Sentence: Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
Instructions: please typing these entity words according to sentence: TbPRMT5, TbPRMT5, PRMT5, Skb1, TbPRMT5, RBP16, TbPRMT5, TbPRMT5, TbPRMT5, Ded1, TbPRMT5
Options: Protein
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Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
|
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[
"Protein"
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TbPRMT5, TbPRMT5, PRMT5, Skb1, TbPRMT5, RBP16, TbPRMT5, TbPRMT5, TbPRMT5, Ded1, TbPRMT5
|
245_task2
|
Sentence: Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
Instructions: please extract entity words from the input sentence
|
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Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.
Protein arginine methylation is a posttranslational modification that impacts cellular functions, such as RNA processing, transcription, DNA repair, and signal transduction. The majority of our knowledge regarding arginine methylation derives from studies of yeast and mammals. Here, we describe a protein arginine N-methyltransferase (PRMT), TbPRMT5, from the early-branching eukaryote Trypanosoma brucei. TbPRMT5 shares the greatest sequence similarity with PRMT5 and Skb1 type II enzymes from humans and Schizosaccharomyces pombe, respectively, although it is significantly divergent at the amino acid level from its mammalian and yeast counterparts. Recombinant TbPRMT5 displays broad substrate specificity in vitro, including methylation of a mitochondrial-gene-regulatory protein, RBP16. TbPRMT5 catalyzes the formation of omega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine and does not require trypanosome cofactors for this activity. These data establish that type II PRMTs evolved early in the eukaryotic lineage. In vivo, TbPRMT5 is constitutively expressed in the bloodstream form and procyclic-form (insect host) life stages of the parasite and localizes to the cytoplasm. Genetic disruption via RNA interference in procyclic-form trypanosomes indicates that TbPRMT5 is not essential for growth in this life cycle stage. TbPRMT5-TAP ectopically expressed in procyclic-form trypanosomes is present in high-molecular-weight complexes and associates with an RG domain-containing DEAD box protein related to yeast Ded1 and two kinetoplastid-specific proteins. Thus, TbPRMT5 is likely to be involved in novel methylation-regulated functions in trypanosomes, some of which may include RNA processing and/or translation.
|
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[
"Protein"
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O - GlcNAc is a protein, OGT is a protein, UDP - GlcNAc is a compound
|
DS.d547_task0
|
Sentence: We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: compound, protein
|
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We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
|
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[
"compound",
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O - GlcNAc is a protein, OGT is a protein, UDP - GlcNAc is a compound
|
DS.d547_task1
|
Sentence: We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
Instructions: please typing these entity words according to sentence: O - GlcNAc, OGT, UDP - GlcNAc
Options: compound, protein
|
[
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We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
|
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[
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O - GlcNAc, OGT, UDP - GlcNAc
|
DS.d547_task2
|
Sentence: We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
Instructions: please extract entity words from the input sentence
|
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We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.
|
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imaging is an umlsterm, findings is an umlsterm, diseases is an umlsterm, pharynx is an umlsterm, complications is an umlsterm
|
DerRadiologe.00400619.eng.abstr_task0
|
Sentence: Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
"O",
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"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
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Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
|
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[
"umlsterm"
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imaging is an umlsterm, findings is an umlsterm, diseases is an umlsterm, pharynx is an umlsterm, complications is an umlsterm
|
DerRadiologe.00400619.eng.abstr_task1
|
Sentence: Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
Instructions: please typing these entity words according to sentence: imaging, findings, diseases, pharynx, complications
Options: umlsterm
|
[
"O",
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"O",
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"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
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"O"
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Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
|
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[
"umlsterm"
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imaging, findings, diseases, pharynx, complications
|
DerRadiologe.00400619.eng.abstr_task2
|
Sentence: Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
Instructions: please extract entity words from the input sentence
|
[
"O",
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"O",
"O",
"B-umlsterm",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O"
] |
Purpose . To demonstrate imaging findings in inflammatory diseases of the pharynx and possible complications .
|
[
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] |
[
"umlsterm"
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ubiquitin is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, tau is a Protein, SOD1 is a Protein, ubiquitin is a Protein, ubiquitin is a Protein
|
273_task0
|
Sentence: Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether the topology of ubiquitin linkages influences the dynamics of inclusions is not well explored. Here, we report that lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitination, as well as monoubiquitin modification contribute to the biogenesis of inclusions. K63-linked polyubiquitin is the most consistent enhancer of inclusions formation. Under basal conditions, ectopic expression of K63 mutant ubiquitin in cultured cells promotes the accumulation of proteins and the formation of intracellular inclusions in the apparent absence of proteasome impairment. When co-expressed with disease-associated tau and SOD1 mutants, K63 ubiquitin mutant facilitates the formation of tau- and SOD-1-positive inclusions. Moreover, K63-linked ubiquitination was found to selectively facilitate the clearance of inclusions via autophagy. These data indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system. Collectively, our results provide a novel mechanistic route that underlies the life cycle of an inclusion body. Harnessing this pathway may offer innovative approaches in the treatment of neurodegenerative disorders.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Protein
|
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Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
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|
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[
"Protein"
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ubiquitin is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, tau is a Protein, SOD1 is a Protein, ubiquitin is a Protein, ubiquitin is a Protein
|
273_task1
|
Sentence: Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether the topology of ubiquitin linkages influences the dynamics of inclusions is not well explored. Here, we report that lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitination, as well as monoubiquitin modification contribute to the biogenesis of inclusions. K63-linked polyubiquitin is the most consistent enhancer of inclusions formation. Under basal conditions, ectopic expression of K63 mutant ubiquitin in cultured cells promotes the accumulation of proteins and the formation of intracellular inclusions in the apparent absence of proteasome impairment. When co-expressed with disease-associated tau and SOD1 mutants, K63 ubiquitin mutant facilitates the formation of tau- and SOD-1-positive inclusions. Moreover, K63-linked ubiquitination was found to selectively facilitate the clearance of inclusions via autophagy. These data indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system. Collectively, our results provide a novel mechanistic route that underlies the life cycle of an inclusion body. Harnessing this pathway may offer innovative approaches in the treatment of neurodegenerative disorders.
Instructions: please typing these entity words according to sentence: ubiquitin, ubiquitin, ubiquitin, tau, SOD1, ubiquitin, ubiquitin
Options: Protein
|
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Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
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|
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[
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ubiquitin, ubiquitin, ubiquitin, tau, SOD1, ubiquitin, ubiquitin
|
273_task2
|
Sentence: Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether the topology of ubiquitin linkages influences the dynamics of inclusions is not well explored. Here, we report that lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitination, as well as monoubiquitin modification contribute to the biogenesis of inclusions. K63-linked polyubiquitin is the most consistent enhancer of inclusions formation. Under basal conditions, ectopic expression of K63 mutant ubiquitin in cultured cells promotes the accumulation of proteins and the formation of intracellular inclusions in the apparent absence of proteasome impairment. When co-expressed with disease-associated tau and SOD1 mutants, K63 ubiquitin mutant facilitates the formation of tau- and SOD-1-positive inclusions. Moreover, K63-linked ubiquitination was found to selectively facilitate the clearance of inclusions via autophagy. These data indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system. Collectively, our results provide a novel mechanistic route that underlies the life cycle of an inclusion body. Harnessing this pathway may offer innovative approaches in the treatment of neurodegenerative disorders.
Instructions: please extract entity words from the input sentence
|
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Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether the topology of ubiquitin linkages influences the dynamics of inclusions is not well explored. Here, we report that lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitination, as well as monoubiquitin modification contribute to the biogenesis of inclusions. K63-linked polyubiquitin is the most consistent enhancer of inclusions formation. Under basal conditions, ectopic expression of K63 mutant ubiquitin in cultured cells promotes the accumulation of proteins and the formation of intracellular inclusions in the apparent absence of proteasome impairment. When co-expressed with disease-associated tau and SOD1 mutants, K63 ubiquitin mutant facilitates the formation of tau- and SOD-1-positive inclusions. Moreover, K63-linked ubiquitination was found to selectively facilitate the clearance of inclusions via autophagy. These data indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system. Collectively, our results provide a novel mechanistic route that underlies the life cycle of an inclusion body. Harnessing this pathway may offer innovative approaches in the treatment of neurodegenerative disorders.
|
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[
"Protein"
] |
acetyltransferase is a protein, C3d is a compound
|
DS.d1703_task0
|
Sentence: Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: compound, protein
|
[
"O",
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"B-protein",
"O",
"B-compound",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
|
[
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"by",
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"a",
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"cell",
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"ligand",
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] |
[
"protein",
"compound"
] |
acetyltransferase is a protein, C3d is a compound
|
DS.d1703_task1
|
Sentence: Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
Instructions: please typing these entity words according to sentence: acetyltransferase, C3d
Options: compound, protein
|
[
"O",
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"O",
"B-compound",
"O",
"O",
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"O",
"O",
"O",
"O",
"O"
] |
Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
|
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"a",
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] |
[
"protein",
"compound"
] |
acetyltransferase, C3d
|
DS.d1703_task2
|
Sentence: Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
Instructions: please extract entity words from the input sentence
|
[
"O",
"O",
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"O",
"O",
"O",
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"O"
] |
Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.
|
[
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] |
[
"protein",
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Developments is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, complications is an umlsterm, literature is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, patients is an umlsterm, goitres is an umlsterm, operations is an umlsterm, disease is an umlsterm, malignant is an umlsterm, diseases is an umlsterm, operations is an umlsterm, literature is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, surgical treatment is an umlsterm, hyperthyroidism is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, patients is an umlsterm, disease is an umlsterm, operation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, malignancies is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, secondary is an umlsterm, operation is an umlsterm, postoperative is an umlsterm, attention is an umlsterm, asphyxia is an umlsterm, care is an umlsterm, treatment is an umlsterm
|
DerChirurg.90700999.eng.abstr_task0
|
Sentence: Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
|
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[
"umlsterm"
] |
Developments is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, complications is an umlsterm, literature is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, patients is an umlsterm, goitres is an umlsterm, operations is an umlsterm, disease is an umlsterm, malignant is an umlsterm, diseases is an umlsterm, operations is an umlsterm, literature is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, thyroid is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, surgical treatment is an umlsterm, hyperthyroidism is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, patients is an umlsterm, disease is an umlsterm, operation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, malignancies is an umlsterm, laryngeal nerve is an umlsterm, paralysis is an umlsterm, hypoparathyroidism is an umlsterm, secondary is an umlsterm, operation is an umlsterm, postoperative is an umlsterm, attention is an umlsterm, asphyxia is an umlsterm, care is an umlsterm, treatment is an umlsterm
|
DerChirurg.90700999.eng.abstr_task1
|
Sentence: Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
Instructions: please typing these entity words according to sentence: Developments, thyroid, surgery, complications, literature, laryngeal nerve, paralysis, hypoparathyroidism, patients, goitres, operations, disease, malignant, diseases, operations, literature, thyroid, surgery, laryngeal nerve, paralysis, thyroid, surgery, surgery, surgical treatment, hyperthyroidism, laryngeal nerve, paralysis, hypoparathyroidism, patients, disease, operation, patients, thyroid, malignancies, laryngeal nerve, paralysis, hypoparathyroidism, secondary, operation, postoperative, attention, asphyxia, care, treatment
Options: umlsterm
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Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
|
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[
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|
DerChirurg.90700999.eng.abstr_task2
|
Sentence: Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
Instructions: please extract entity words from the input sentence
|
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Developments in thyroid surgery during the last 20 years have reduced the number of complications significantly with rates from the literature of less than 1 % of laryngeal nerve paralysis and hypoparathyroidism . Specific problems are connected , however , with patients presenting with recurrent goitres , requiring extended operations for Graves ' disease and for malignant diseases . Our own experience in almost 6,000 operations during the last 12 years comfirms the results from the literature with regard to more complicated thyroid surgery . Thus , laryngeal nerve paralysis in recurrent thyroid surgery is between 2 and 8 % , depending on the extent of surgery , which is necessary . In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases . The same is true for patients with thyroid malignancies who suffer from permanent laryngeal nerve paralysis in 2-5 % and permanent hypoparathyroidism in 1-4 % , the range related to primary , secondary completion , or recurrent operation . The danger of postoperative bleeding still deserves special attention because it may be followed by life-threatening acute asphyxia . It is essential that surgeons also take care of all operative consequences at least by recommendating additional treatment .
|
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[
"umlsterm"
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Optune compliance is a Observation, < 75 % is a Multiplier, craniectomy is a Procedure, significant is a Qualifier, skull defect is a Condition, contraindication is a Condition, Optune is a Device, Active is a Qualifier, implantable medical device is a Device, DBS , spinal cord stimulator , pacemaker , defibrillator , vagus nerve stimulator , programmable shunt is a Scope, Karnofsky Performance Status is a Measurement, KPS is a Measurement, < 60 is a Value
|
NCT03297125_exc_task0
|
Sentence: Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Condition, Measurement, Qualifier, Value, Observation, Multiplier, Procedure, Scope, Device
|
[
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] |
Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
|
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] |
Optune compliance is a Observation, < 75 % is a Multiplier, craniectomy is a Procedure, significant is a Qualifier, skull defect is a Condition, contraindication is a Condition, Optune is a Device, Active is a Qualifier, implantable medical device is a Device, DBS , spinal cord stimulator , pacemaker , defibrillator , vagus nerve stimulator , programmable shunt is a Scope, Karnofsky Performance Status is a Measurement, KPS is a Measurement, < 60 is a Value
|
NCT03297125_exc_task1
|
Sentence: Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
Instructions: please typing these entity words according to sentence: Optune compliance, < 75 %, craniectomy, significant, skull defect, contraindication, Optune, Active, implantable medical device, DBS , spinal cord stimulator , pacemaker , defibrillator , vagus nerve stimulator , programmable shunt, Karnofsky Performance Status, KPS, < 60
Options: Condition, Measurement, Qualifier, Value, Observation, Multiplier, Procedure, Scope, Device
|
[
"B-Observation",
"I-Observation",
"B-Multiplier",
"I-Multiplier",
"I-Multiplier",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Procedure",
"O",
"B-Qualifier",
"B-Condition",
"I-Condition",
"O",
"B-Condition",
"O",
"B-Device",
"O",
"O",
"O",
"B-Qualifier",
"B-Device",
"I-Device",
"I-Device",
"O",
"O",
"O",
"B-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
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"O",
"O",
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"I-Measurement",
"I-Measurement",
"O",
"B-Measurement",
"O",
"B-Value",
"I-Value",
"O",
"O"
] |
Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
|
[
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[
"Scope",
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"Multiplier",
"Value"
] |
Optune compliance, < 75 %, craniectomy, significant, skull defect, contraindication, Optune, Active, implantable medical device, DBS , spinal cord stimulator , pacemaker , defibrillator , vagus nerve stimulator , programmable shunt, Karnofsky Performance Status, KPS, < 60
|
NCT03297125_exc_task2
|
Sentence: Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
Instructions: please extract entity words from the input sentence
|
[
"B-Observation",
"I-Observation",
"B-Multiplier",
"I-Multiplier",
"I-Multiplier",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-Procedure",
"O",
"B-Qualifier",
"B-Condition",
"I-Condition",
"O",
"B-Condition",
"O",
"B-Device",
"O",
"O",
"O",
"B-Qualifier",
"B-Device",
"I-Device",
"I-Device",
"O",
"O",
"O",
"B-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"I-Scope",
"O",
"O",
"O",
"B-Measurement",
"I-Measurement",
"I-Measurement",
"O",
"B-Measurement",
"O",
"B-Value",
"I-Value",
"O",
"O"
] |
Optune compliance < 75%; they would be excluded from the final analyses.
History of craniectomy or significant skull defect (contraindication to Optune).
Active implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).
Karnofsky Performance Status (KPS) < 60.
|
[
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[
"Scope",
"Measurement",
"Device",
"Observation",
"Condition",
"Procedure",
"Qualifier",
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"Value"
] |
Innenohrschwerhoerigen is an umlsterm, selbst is an umlsterm, Hoergeraetetechnik is an umlsterm, Patienten is an umlsterm, Hoergeraete is an umlsterm, Hoergeraeten is an umlsterm, Klangtreue is an umlsterm, Sprachverstaendlichkeit is an umlsterm, Kopf is an umlsterm, Raumorientierung is an umlsterm, aeusseren Gehoergangs is an umlsterm, trommelfellnahes is an umlsterm, Gehoergangshaut is an umlsterm, Ambosskoerper is an umlsterm, Patienten is an umlsterm, Sprache is an umlsterm, Musik is an umlsterm, Stoerlaerm is an umlsterm, Sprachverstaendnis is an umlsterm, Implantationserfahrungen is an umlsterm
|
HNO.80460844.ger.abstr_task0
|
Sentence: Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"I-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
|
[
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] |
[
"umlsterm"
] |
Innenohrschwerhoerigen is an umlsterm, selbst is an umlsterm, Hoergeraetetechnik is an umlsterm, Patienten is an umlsterm, Hoergeraete is an umlsterm, Hoergeraeten is an umlsterm, Klangtreue is an umlsterm, Sprachverstaendlichkeit is an umlsterm, Kopf is an umlsterm, Raumorientierung is an umlsterm, aeusseren Gehoergangs is an umlsterm, trommelfellnahes is an umlsterm, Gehoergangshaut is an umlsterm, Ambosskoerper is an umlsterm, Patienten is an umlsterm, Sprache is an umlsterm, Musik is an umlsterm, Stoerlaerm is an umlsterm, Sprachverstaendnis is an umlsterm, Implantationserfahrungen is an umlsterm
|
HNO.80460844.ger.abstr_task1
|
Sentence: Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
Instructions: please typing these entity words according to sentence: Innenohrschwerhoerigen, selbst, Hoergeraetetechnik, Patienten, Hoergeraete, Hoergeraeten, Klangtreue, Sprachverstaendlichkeit, Kopf, Raumorientierung, aeusseren Gehoergangs, trommelfellnahes, Gehoergangshaut, Ambosskoerper, Patienten, Sprache, Musik, Stoerlaerm, Sprachverstaendnis, Implantationserfahrungen
Options: umlsterm
|
[
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"O",
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"B-umlsterm",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
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"O",
"O",
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"O",
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"O",
"O",
"O",
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"O",
"O",
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"O",
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"B-umlsterm",
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"B-umlsterm",
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"O",
"O",
"O",
"O",
"O"
] |
Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
|
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[
"umlsterm"
] |
Innenohrschwerhoerigen, selbst, Hoergeraetetechnik, Patienten, Hoergeraete, Hoergeraeten, Klangtreue, Sprachverstaendlichkeit, Kopf, Raumorientierung, aeusseren Gehoergangs, trommelfellnahes, Gehoergangshaut, Ambosskoerper, Patienten, Sprache, Musik, Stoerlaerm, Sprachverstaendnis, Implantationserfahrungen
|
HNO.80460844.ger.abstr_task2
|
Sentence: Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
Instructions: please extract entity words from the input sentence
|
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Zusammenfassung : Fuer die Mehrzahl der Innenohrschwerhoerigen kann selbst mit modernster Hoergeraetetechnik keine die Patienten zufriedenstellende Hoerrehabilitation erzielt werden . Fuer diese grosse Zahl von Betroffenen ohne adaequate Versorgung sind teilimplantierbare Hoergeraete entwickelt worden , die konventionellen Hoergeraeten besonders bei Klangtreue und Sprachverstaendlichkeit deutlich ueberlegen sein koennen . Allerdings koennen sie den Kranken durch aussen an Kopf oder Koerper zu tragende Teile stigmatisieren . Auch nutzen sie die Stoerschallunterdrueckung als auch die auditorische Raumorientierung mittels des aeusseren Gehoergangs noch nicht aus . Hier berichten wir ueber die ersten Implantationen eines neuartigen , vollstaendig implantierbaren Hoersystems ( TICA LZ 3001 ) bei Innenohrschwerhoerigen . Es nimmt den Schall ueber ein trommelfellnahes Mikrophon durch die intakte Gehoergangshaut auf . Ein retroaurikulaer subkutan implantierter , mehrkanaliger digital programmierbarer Audioprozessor verarbeitet das Signal und gibt es ueber einen piezoelektronischen Wandler im Mastoid an den Ambosskoerper weiter . Energie wird durch eine implantierbare Batterie bereitgestellt . Implantierte Patienten empfinden das Gehoerte als verzerrungsfrei und transparent . Sie verstehen Sprache und empfinden Musik besser als ohne Implantat . Insbesondere im Stoerlaerm kann z.T. ein erheblich verbessertes Sprachverstaendnis erreicht werden . Die bisherigen Ergebnisse ermutigen , weitere Implantationserfahrungen mit dem vollstaendig implantierbaren Hoersystem zu sammeln .
|
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[
"umlsterm"
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prevalence is an umlsterm, disorders is an umlsterm, patients is an umlsterm, implantable cardioverter - defibrillator is an umlsterm, arrhythmia is an umlsterm, recurrence is an umlsterm, arrhythmia is an umlsterm, variation is an umlsterm, mortality is an umlsterm, cardiac disease is an umlsterm, history is an umlsterm, tachyarrhythmias is an umlsterm, polysomnography is an umlsterm, patients is an umlsterm, Index is an umlsterm, patients is an umlsterm, sleep apneas is an umlsterm, patients is an umlsterm, Cheyne - Stokes respiration is an umlsterm, patients is an umlsterm, obstructive sleep apneas is an umlsterm, patients is an umlsterm, patients is an umlsterm, Patients is an umlsterm, ventricular ejection fraction is an umlsterm, classification is an umlsterm, cardiac disease is an umlsterm, medication is an umlsterm, tachyarrhythmias is an umlsterm, patients is an umlsterm, patients is an umlsterm, patients is an umlsterm, variation is an umlsterm, patients is an umlsterm, mortality is an umlsterm, patients is an umlsterm, patients is an umlsterm, patients is an umlsterm, prevalence is an umlsterm, patients is an umlsterm, heart is an umlsterm, history is an umlsterm, malignant is an umlsterm, tachyarrhythmias is an umlsterm, occurrence is an umlsterm, mortality is an umlsterm, patients is an umlsterm, arrhythmia is an umlsterm, recurrence is an umlsterm, variation is an umlsterm
|
ZfuerKardiologie.80870826.eng.abstr_task0
|
Sentence: The purpose of our study was to determine the prevalence of sleep related breathing disorders ( SRBD ) in patients with an implantable cardioverter-defibrillator ( ICD ) and to evaluate prospectively the possible influence of SRBD on arrhythmia recurrence and circadian arrhythmia variation as well as on cardiac mortality during long-term follow-up . Forty consecutive ICD recipients with cardiac disease and a documented history of spontaneous , life-threatening , ventricular tachyarrhythmias underwent fullnight polysomnography and were followed for 2 years . In 16 of 40 patients ( 40% ) , SRBD were diagnosed ( Apnea/Hypopnea Index ( AHI ) > 10 ) ; in 9 of these 16 patients ( 56% ) central sleep apneas ( CSA ) occurred ( in 8 of these 9 patients in combination with Cheyne-Stokes respiration ) . Seven of the 16 patients with SRBD ( 44% ) revealed obstructive sleep apneas ( OSA ) . AHI was 32 +/- 15 ( 12-60 ) in patients with CSA and 32 +/- 27 ( 11-86 ) in patients with OSA . Patients with and without SRBD were comparable concerning left ventricular ejection fraction , NYHA classification , cardiac disease , ICD indication , and concomitant medication . ICD registered ventricular tachyarrhythmias occurred in 10 of 24 patients ( 42% ) without SRBD , in 4 of 9 patients ( 44% ) with CSA , and in 3 of 7 patients ( 44% ) with OSA . The numbers and circadian variation of episodes registered during follow-up in patients without SRBD , with OSA or CSA were comparable ( 14 +/- 25 , median 4 vs 15 +/- 15 , median 7 vs 4 +/- 5 , median 2.5 ) . The 2-year cardiac mortality was highest in patients with CSA ( 4/9 ( 44% ) vs 0/7 patients ( 0% ) with OSA vs 3/24 patients ( 12.5% ) without SRBD . Thus , the prevalence of SRBD in patients with chronic heart failure and a history of malignant ventricular tachyarrhythmias is high ( 40% ) and the occurrence of CSA seems to be predictive for cardiac mortality in these patients . An influence of moderate SRBD on arrhythmia recurrence and circadian variation of spontaneous sustained tachyarrhythmic events could not be demonstrated .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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The purpose of our study was to determine the prevalence of sleep related breathing disorders ( SRBD ) in patients with an implantable cardioverter-defibrillator ( ICD ) and to evaluate prospectively the possible influence of SRBD on arrhythmia recurrence and circadian arrhythmia variation as well as on cardiac mortality during long-term follow-up . Forty consecutive ICD recipients with cardiac disease and a documented history of spontaneous , life-threatening , ventricular tachyarrhythmias underwent fullnight polysomnography and were followed for 2 years . In 16 of 40 patients ( 40% ) , SRBD were diagnosed ( Apnea/Hypopnea Index ( AHI ) > 10 ) ; in 9 of these 16 patients ( 56% ) central sleep apneas ( CSA ) occurred ( in 8 of these 9 patients in combination with Cheyne-Stokes respiration ) . Seven of the 16 patients with SRBD ( 44% ) revealed obstructive sleep apneas ( OSA ) . AHI was 32 +/- 15 ( 12-60 ) in patients with CSA and 32 +/- 27 ( 11-86 ) in patients with OSA . Patients with and without SRBD were comparable concerning left ventricular ejection fraction , NYHA classification , cardiac disease , ICD indication , and concomitant medication . ICD registered ventricular tachyarrhythmias occurred in 10 of 24 patients ( 42% ) without SRBD , in 4 of 9 patients ( 44% ) with CSA , and in 3 of 7 patients ( 44% ) with OSA . The numbers and circadian variation of episodes registered during follow-up in patients without SRBD , with OSA or CSA were comparable ( 14 +/- 25 , median 4 vs 15 +/- 15 , median 7 vs 4 +/- 5 , median 2.5 ) . The 2-year cardiac mortality was highest in patients with CSA ( 4/9 ( 44% ) vs 0/7 patients ( 0% ) with OSA vs 3/24 patients ( 12.5% ) without SRBD . Thus , the prevalence of SRBD in patients with chronic heart failure and a history of malignant ventricular tachyarrhythmias is high ( 40% ) and the occurrence of CSA seems to be predictive for cardiac mortality in these patients . An influence of moderate SRBD on arrhythmia recurrence and circadian variation of spontaneous sustained tachyarrhythmic events could not be demonstrated .
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ZfuerKardiologie.80870826.eng.abstr_task1
|
Sentence: The purpose of our study was to determine the prevalence of sleep related breathing disorders ( SRBD ) in patients with an implantable cardioverter-defibrillator ( ICD ) and to evaluate prospectively the possible influence of SRBD on arrhythmia recurrence and circadian arrhythmia variation as well as on cardiac mortality during long-term follow-up . Forty consecutive ICD recipients with cardiac disease and a documented history of spontaneous , life-threatening , ventricular tachyarrhythmias underwent fullnight polysomnography and were followed for 2 years . In 16 of 40 patients ( 40% ) , SRBD were diagnosed ( Apnea/Hypopnea Index ( AHI ) > 10 ) ; in 9 of these 16 patients ( 56% ) central sleep apneas ( CSA ) occurred ( in 8 of these 9 patients in combination with Cheyne-Stokes respiration ) . Seven of the 16 patients with SRBD ( 44% ) revealed obstructive sleep apneas ( OSA ) . AHI was 32 +/- 15 ( 12-60 ) in patients with CSA and 32 +/- 27 ( 11-86 ) in patients with OSA . Patients with and without SRBD were comparable concerning left ventricular ejection fraction , NYHA classification , cardiac disease , ICD indication , and concomitant medication . ICD registered ventricular tachyarrhythmias occurred in 10 of 24 patients ( 42% ) without SRBD , in 4 of 9 patients ( 44% ) with CSA , and in 3 of 7 patients ( 44% ) with OSA . The numbers and circadian variation of episodes registered during follow-up in patients without SRBD , with OSA or CSA were comparable ( 14 +/- 25 , median 4 vs 15 +/- 15 , median 7 vs 4 +/- 5 , median 2.5 ) . The 2-year cardiac mortality was highest in patients with CSA ( 4/9 ( 44% ) vs 0/7 patients ( 0% ) with OSA vs 3/24 patients ( 12.5% ) without SRBD . Thus , the prevalence of SRBD in patients with chronic heart failure and a history of malignant ventricular tachyarrhythmias is high ( 40% ) and the occurrence of CSA seems to be predictive for cardiac mortality in these patients . An influence of moderate SRBD on arrhythmia recurrence and circadian variation of spontaneous sustained tachyarrhythmic events could not be demonstrated .
Instructions: please typing these entity words according to sentence: prevalence, disorders, patients, implantable cardioverter - defibrillator, arrhythmia, recurrence, arrhythmia, variation, mortality, cardiac disease, history, tachyarrhythmias, polysomnography, patients, Index, patients, sleep apneas, patients, Cheyne - Stokes respiration, patients, obstructive sleep apneas, patients, patients, Patients, ventricular ejection fraction, classification, cardiac disease, medication, tachyarrhythmias, patients, patients, patients, variation, patients, mortality, patients, patients, patients, prevalence, patients, heart, history, malignant, tachyarrhythmias, occurrence, mortality, patients, arrhythmia, recurrence, variation
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[
"umlsterm"
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prevalence, disorders, patients, implantable cardioverter - defibrillator, arrhythmia, recurrence, arrhythmia, variation, mortality, cardiac disease, history, tachyarrhythmias, polysomnography, patients, Index, patients, sleep apneas, patients, Cheyne - Stokes respiration, patients, obstructive sleep apneas, patients, patients, Patients, ventricular ejection fraction, classification, cardiac disease, medication, tachyarrhythmias, patients, patients, patients, variation, patients, mortality, patients, patients, patients, prevalence, patients, heart, history, malignant, tachyarrhythmias, occurrence, mortality, patients, arrhythmia, recurrence, variation
|
ZfuerKardiologie.80870826.eng.abstr_task2
|
Sentence: The purpose of our study was to determine the prevalence of sleep related breathing disorders ( SRBD ) in patients with an implantable cardioverter-defibrillator ( ICD ) and to evaluate prospectively the possible influence of SRBD on arrhythmia recurrence and circadian arrhythmia variation as well as on cardiac mortality during long-term follow-up . Forty consecutive ICD recipients with cardiac disease and a documented history of spontaneous , life-threatening , ventricular tachyarrhythmias underwent fullnight polysomnography and were followed for 2 years . In 16 of 40 patients ( 40% ) , SRBD were diagnosed ( Apnea/Hypopnea Index ( AHI ) > 10 ) ; in 9 of these 16 patients ( 56% ) central sleep apneas ( CSA ) occurred ( in 8 of these 9 patients in combination with Cheyne-Stokes respiration ) . Seven of the 16 patients with SRBD ( 44% ) revealed obstructive sleep apneas ( OSA ) . AHI was 32 +/- 15 ( 12-60 ) in patients with CSA and 32 +/- 27 ( 11-86 ) in patients with OSA . Patients with and without SRBD were comparable concerning left ventricular ejection fraction , NYHA classification , cardiac disease , ICD indication , and concomitant medication . ICD registered ventricular tachyarrhythmias occurred in 10 of 24 patients ( 42% ) without SRBD , in 4 of 9 patients ( 44% ) with CSA , and in 3 of 7 patients ( 44% ) with OSA . The numbers and circadian variation of episodes registered during follow-up in patients without SRBD , with OSA or CSA were comparable ( 14 +/- 25 , median 4 vs 15 +/- 15 , median 7 vs 4 +/- 5 , median 2.5 ) . The 2-year cardiac mortality was highest in patients with CSA ( 4/9 ( 44% ) vs 0/7 patients ( 0% ) with OSA vs 3/24 patients ( 12.5% ) without SRBD . Thus , the prevalence of SRBD in patients with chronic heart failure and a history of malignant ventricular tachyarrhythmias is high ( 40% ) and the occurrence of CSA seems to be predictive for cardiac mortality in these patients . An influence of moderate SRBD on arrhythmia recurrence and circadian variation of spontaneous sustained tachyarrhythmic events could not be demonstrated .
Instructions: please extract entity words from the input sentence
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The purpose of our study was to determine the prevalence of sleep related breathing disorders ( SRBD ) in patients with an implantable cardioverter-defibrillator ( ICD ) and to evaluate prospectively the possible influence of SRBD on arrhythmia recurrence and circadian arrhythmia variation as well as on cardiac mortality during long-term follow-up . Forty consecutive ICD recipients with cardiac disease and a documented history of spontaneous , life-threatening , ventricular tachyarrhythmias underwent fullnight polysomnography and were followed for 2 years . In 16 of 40 patients ( 40% ) , SRBD were diagnosed ( Apnea/Hypopnea Index ( AHI ) > 10 ) ; in 9 of these 16 patients ( 56% ) central sleep apneas ( CSA ) occurred ( in 8 of these 9 patients in combination with Cheyne-Stokes respiration ) . Seven of the 16 patients with SRBD ( 44% ) revealed obstructive sleep apneas ( OSA ) . AHI was 32 +/- 15 ( 12-60 ) in patients with CSA and 32 +/- 27 ( 11-86 ) in patients with OSA . Patients with and without SRBD were comparable concerning left ventricular ejection fraction , NYHA classification , cardiac disease , ICD indication , and concomitant medication . ICD registered ventricular tachyarrhythmias occurred in 10 of 24 patients ( 42% ) without SRBD , in 4 of 9 patients ( 44% ) with CSA , and in 3 of 7 patients ( 44% ) with OSA . The numbers and circadian variation of episodes registered during follow-up in patients without SRBD , with OSA or CSA were comparable ( 14 +/- 25 , median 4 vs 15 +/- 15 , median 7 vs 4 +/- 5 , median 2.5 ) . The 2-year cardiac mortality was highest in patients with CSA ( 4/9 ( 44% ) vs 0/7 patients ( 0% ) with OSA vs 3/24 patients ( 12.5% ) without SRBD . Thus , the prevalence of SRBD in patients with chronic heart failure and a history of malignant ventricular tachyarrhythmias is high ( 40% ) and the occurrence of CSA seems to be predictive for cardiac mortality in these patients . An influence of moderate SRBD on arrhythmia recurrence and circadian variation of spontaneous sustained tachyarrhythmic events could not be demonstrated .
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[
"umlsterm"
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single - stage is an umlsterm, defects is an umlsterm, head is an umlsterm, neck is an umlsterm, forearm is an umlsterm, flaps is an umlsterm, pectoralis is an umlsterm, flaps is an umlsterm, flap is an umlsterm, forearm is an umlsterm, flap is an umlsterm, time is an umlsterm, operations is an umlsterm, Pectoralis is an umlsterm, flaps is an umlsterm, forearm is an umlsterm, flaps is an umlsterm, risks is an umlsterm
|
HNO.60440612.eng.abstr_task0
|
Sentence: The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
|
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[
"umlsterm"
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|
HNO.60440612.eng.abstr_task1
|
Sentence: The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
Instructions: please typing these entity words according to sentence: single - stage, defects, head, neck, forearm, flaps, pectoralis, flaps, flap, forearm, flap, time, operations, Pectoralis, flaps, forearm, flaps, risks
Options: umlsterm
|
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The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
|
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[
"umlsterm"
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single - stage, defects, head, neck, forearm, flaps, pectoralis, flaps, flap, forearm, flap, time, operations, Pectoralis, flaps, forearm, flaps, risks
|
HNO.60440612.eng.abstr_task2
|
Sentence: The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
Instructions: please extract entity words from the input sentence
|
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The results of 13 single-stage reconstructions of large and complex defects in the head and neck by using eight free radial forearm flaps as well as five pectoralis major myocutaneous flaps were analyzed . No complete flap loss occurred in any case . The results with radial forearm flap reconstructions proved to be better functionally and aesthetically . Due to the time needed for the microvascular anastomoses , the length of the operations was sometimes prolonged . Pectoralis major flaps were found to be more difficult to handle and were used in those cases in which the application of free radial forearm flaps was expected to produce higher risks .
|
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[
"umlsterm"
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Lymphomen is an umlsterm, Lymphom - Studiengruppe is an umlsterm, Klassifikation is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, lymphatischen Gewebes is an umlsterm, Diagnose is an umlsterm, Biopsien is an umlsterm, Diagnostik is an umlsterm
|
DerPathologe.50160328.ger.abstr_task0
|
Sentence: Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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] |
Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
|
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[
"umlsterm"
] |
Lymphomen is an umlsterm, Lymphom - Studiengruppe is an umlsterm, Klassifikation is an umlsterm, Neoplasien is an umlsterm, Neoplasien is an umlsterm, lymphatischen Gewebes is an umlsterm, Diagnose is an umlsterm, Biopsien is an umlsterm, Diagnostik is an umlsterm
|
DerPathologe.50160328.ger.abstr_task1
|
Sentence: Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
Instructions: please typing these entity words according to sentence: Lymphomen, Lymphom - Studiengruppe, Klassifikation, Neoplasien, Neoplasien, lymphatischen Gewebes, Diagnose, Biopsien, Diagnostik
Options: umlsterm
|
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"O",
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] |
Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
|
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[
"umlsterm"
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Lymphomen, Lymphom - Studiengruppe, Klassifikation, Neoplasien, Neoplasien, lymphatischen Gewebes, Diagnose, Biopsien, Diagnostik
|
DerPathologe.50160328.ger.abstr_task2
|
Sentence: Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
Instructions: please extract entity words from the input sentence
|
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Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen , molekulargenetischen und klinischen Eigenschaften . Nach den Vorschlaegen der Internationalen Lymphom-Studiengruppe fuer eine revidierte europaeisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert , die einen niedrigeren oder hoeheren Malignitaetsgrad aufweisen koennen . Wir wandten dieses Klassifikationskonzept auf 24 Faelle primaerer pulmonaler B-Zell-Lymphome an . Alle Faelle zeigten histologische Merkmale niedrigmaligner ( n = 20 ) und/oder hochmaligner Neoplasien ( n = 4 ) , die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes ( BALT ) rekapitulierten . Nach unserer Erfahrung , ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten , sondern auch an Biopsien in der praktischen Diagnostik moeglich und reproduzierbar .
|
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[
"umlsterm"
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aelterer Menschen is an umlsterm, Gesamtbevoelkerung is an umlsterm, Herzen is an umlsterm, Patienten is an umlsterm, Langzeitergebnisse is an umlsterm, Myokardrevaskularisation is an umlsterm, Lebensdekade is an umlsterm
|
ZfuerGerontologie+Geriatrie.00330381.ger.abstr_task0
|
Sentence: Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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] |
Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
|
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[
"umlsterm"
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aelterer Menschen is an umlsterm, Gesamtbevoelkerung is an umlsterm, Herzen is an umlsterm, Patienten is an umlsterm, Langzeitergebnisse is an umlsterm, Myokardrevaskularisation is an umlsterm, Lebensdekade is an umlsterm
|
ZfuerGerontologie+Geriatrie.00330381.ger.abstr_task1
|
Sentence: Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
Instructions: please typing these entity words according to sentence: aelterer Menschen, Gesamtbevoelkerung, Herzen, Patienten, Langzeitergebnisse, Myokardrevaskularisation, Lebensdekade
Options: umlsterm
|
[
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"O"
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Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
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[
"umlsterm"
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aelterer Menschen, Gesamtbevoelkerung, Herzen, Patienten, Langzeitergebnisse, Myokardrevaskularisation, Lebensdekade
|
ZfuerGerontologie+Geriatrie.00330381.ger.abstr_task2
|
Sentence: Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
Instructions: please extract entity words from the input sentence
|
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Bei einem zunehmenden Anteil aelterer Menschen an der Gesamtbevoelkerung und infolge des medizinisch-technischen Fortschritts waechst das Durchschnittsalter der am Herzen operierten Patienten . Wir haben daher die Kurz- und Langzeitergebnisse der isolierten Myokardrevaskularisation in der neunten Lebensdekade untersucht .
|
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|
ZfuerRheumatologie.90580207.eng.abstr_task0
|
Sentence: In rheumatic diseases , radiation synovectomy is a reliable method . Meanwhile , radiation synovectomy is an outpatient therapy . In addition , combination with arthroscopic synovectomy is an increasing therapeutic modality . In comparison to the hitherto inpatient modality , a greater lymphatic emigration of the radionuclide and , therefore , a higher radiation exposure is possible . In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy , resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 ( 0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalitites resulted in no statistical difference ( p > 0.05 ) . Because of the found radionuclide emigration , a radiation dose of 0.1 ( 0.05-0,18) mSv in women and 0.2 ( 0.1-0.38) mSv in men was calculated . For lymph nodes , liver , spleen and whole body radiation doses of 619 ( 154-1644 ) mSv , 62 ( 15-165 ) mSv , 62 ( 15-165 ) mSv and 37 ( 9-99 ) mSv were calculated . Gonadal radiation dose can be neglected and the morbidity rate for tumors bacause of the whole body radiation dose is low with a value of 0.4 per thousand . Therefore , radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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] |
In rheumatic diseases , radiation synovectomy is a reliable method . Meanwhile , radiation synovectomy is an outpatient therapy . In addition , combination with arthroscopic synovectomy is an increasing therapeutic modality . In comparison to the hitherto inpatient modality , a greater lymphatic emigration of the radionuclide and , therefore , a higher radiation exposure is possible . In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy , resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 ( 0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalitites resulted in no statistical difference ( p > 0.05 ) . Because of the found radionuclide emigration , a radiation dose of 0.1 ( 0.05-0,18) mSv in women and 0.2 ( 0.1-0.38) mSv in men was calculated . For lymph nodes , liver , spleen and whole body radiation doses of 619 ( 154-1644 ) mSv , 62 ( 15-165 ) mSv , 62 ( 15-165 ) mSv and 37 ( 9-99 ) mSv were calculated . Gonadal radiation dose can be neglected and the morbidity rate for tumors bacause of the whole body radiation dose is low with a value of 0.4 per thousand . Therefore , radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality .
|
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|
ZfuerRheumatologie.90580207.eng.abstr_task1
|
Sentence: In rheumatic diseases , radiation synovectomy is a reliable method . Meanwhile , radiation synovectomy is an outpatient therapy . In addition , combination with arthroscopic synovectomy is an increasing therapeutic modality . In comparison to the hitherto inpatient modality , a greater lymphatic emigration of the radionuclide and , therefore , a higher radiation exposure is possible . In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy , resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 ( 0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalitites resulted in no statistical difference ( p > 0.05 ) . Because of the found radionuclide emigration , a radiation dose of 0.1 ( 0.05-0,18) mSv in women and 0.2 ( 0.1-0.38) mSv in men was calculated . For lymph nodes , liver , spleen and whole body radiation doses of 619 ( 154-1644 ) mSv , 62 ( 15-165 ) mSv , 62 ( 15-165 ) mSv and 37 ( 9-99 ) mSv were calculated . Gonadal radiation dose can be neglected and the morbidity rate for tumors bacause of the whole body radiation dose is low with a value of 0.4 per thousand . Therefore , radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality .
Instructions: please typing these entity words according to sentence: rheumatic diseases, radiation, method, radiation, outpatient, therapy, therapeutic, inpatient, emigration, radionuclide, radiation, patients, radionuclide, emigration, scintigraphy, therapy, radionuclide, emigration, radiation, women, men, lymph nodes, liver, spleen, whole body radiation, radiation, morbidity, tumors, whole body radiation, value, radiation, patients, age, therapeutic
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In rheumatic diseases , radiation synovectomy is a reliable method . Meanwhile , radiation synovectomy is an outpatient therapy . In addition , combination with arthroscopic synovectomy is an increasing therapeutic modality . In comparison to the hitherto inpatient modality , a greater lymphatic emigration of the radionuclide and , therefore , a higher radiation exposure is possible . In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy , resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 ( 0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalitites resulted in no statistical difference ( p > 0.05 ) . Because of the found radionuclide emigration , a radiation dose of 0.1 ( 0.05-0,18) mSv in women and 0.2 ( 0.1-0.38) mSv in men was calculated . For lymph nodes , liver , spleen and whole body radiation doses of 619 ( 154-1644 ) mSv , 62 ( 15-165 ) mSv , 62 ( 15-165 ) mSv and 37 ( 9-99 ) mSv were calculated . Gonadal radiation dose can be neglected and the morbidity rate for tumors bacause of the whole body radiation dose is low with a value of 0.4 per thousand . Therefore , radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality .
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|
ZfuerRheumatologie.90580207.eng.abstr_task2
|
Sentence: In rheumatic diseases , radiation synovectomy is a reliable method . Meanwhile , radiation synovectomy is an outpatient therapy . In addition , combination with arthroscopic synovectomy is an increasing therapeutic modality . In comparison to the hitherto inpatient modality , a greater lymphatic emigration of the radionuclide and , therefore , a higher radiation exposure is possible . In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy , resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 ( 0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalitites resulted in no statistical difference ( p > 0.05 ) . Because of the found radionuclide emigration , a radiation dose of 0.1 ( 0.05-0,18) mSv in women and 0.2 ( 0.1-0.38) mSv in men was calculated . For lymph nodes , liver , spleen and whole body radiation doses of 619 ( 154-1644 ) mSv , 62 ( 15-165 ) mSv , 62 ( 15-165 ) mSv and 37 ( 9-99 ) mSv were calculated . Gonadal radiation dose can be neglected and the morbidity rate for tumors bacause of the whole body radiation dose is low with a value of 0.4 per thousand . Therefore , radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality .
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|
Reproduktionsmedizin.90150336.ger.abstr_task0
|
Sentence: Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
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Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
|
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Praeimplantationsdiagnostik is an umlsterm, Deutschland is an umlsterm, Technik is an umlsterm, Analysen is an umlsterm, Schwangerschaftsabbrueche is an umlsterm, Technik is an umlsterm
|
Reproduktionsmedizin.90150336.ger.abstr_task1
|
Sentence: Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
Instructions: please typing these entity words according to sentence: Praeimplantationsdiagnostik, Deutschland, Technik, Analysen, Schwangerschaftsabbrueche, Technik
Options: umlsterm
|
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Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
|
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[
"umlsterm"
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Praeimplantationsdiagnostik, Deutschland, Technik, Analysen, Schwangerschaftsabbrueche, Technik
|
Reproduktionsmedizin.90150336.ger.abstr_task2
|
Sentence: Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
Instructions: please extract entity words from the input sentence
|
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Gegen die Einfuehrung der Praeimplantationsdiagnostik ( PID ) in Deutschland werden rechtliche und moralische Bedenken vorgebracht . Dieser Artikel stellt die ethischen Argumente fuer und gegen die PID vor und diskutiert sie . Nach Ansicht des Autors lassen weder die Tatsache , dass die PID noch keine ausgereifte Technik ist , noch die Fehleranfaelligkeit genetischer Analysen von Einzelzellen den Schluss zu , dass eine Einfuehrung der PID moralisch unzulaessig ist . Auf Inkonsistenzen in ethischen Positionen , die Schwangerschaftsabbrueche rechtfertigen , den Einsatz der PID hingegen fuer nicht akzeptabel halten , wird hingewiesen . Der Umgang mit Argumenten , die gegen die PID moegliche gesellschaftliche Folgen ihrer Etablierung anfuehren , wird kritisiert . Um den Paaren , die die neue Technik nutzen moechten , eine autonome Entscheidung zu ermoeglichen , wird eine umfassende Aufklaerung vor jeder PID gefordert .
|
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[
"umlsterm"
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postoperative Komplikationen is an umlsterm, Fachgesellschaften is an umlsterm
|
DerChirurg.00710912.ger.abstr_task0
|
Sentence: Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
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] |
Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
|
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] |
[
"umlsterm"
] |
postoperative Komplikationen is an umlsterm, Fachgesellschaften is an umlsterm
|
DerChirurg.00710912.ger.abstr_task1
|
Sentence: Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
Instructions: please typing these entity words according to sentence: postoperative Komplikationen, Fachgesellschaften
Options: umlsterm
|
[
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"O",
"O",
"O",
"O",
"O"
] |
Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
|
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[
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postoperative Komplikationen, Fachgesellschaften
|
DerChirurg.00710912.ger.abstr_task2
|
Sentence: Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
Instructions: please extract entity words from the input sentence
|
[
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"I-umlsterm",
"O",
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"O"
] |
Zusammenfassung . Ziel der perioperativen Antibioticaprophylaxe ( PAP ) ist es , postoperative Komplikationen zu reduzieren . 1994 wurde von US-amerikanischen Fachgesellschaften ein Qualitaetsstandard fuer die PAP entwickelt , wobei die einzelnen Empfehlungen nach ihrem Evidenzgrad in verschiedene Kategorien eingeteilt wurden . Ergaenzt durch die Ergebnisse neuerer randomisierter , kontrollierter Studien sollen die Empfehlungen in tabellarischer Uebersicht dargestellt werden .
|
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[
"umlsterm"
] |
Glukokortikoide is an umlsterm, Geweben is an umlsterm, Saeugetieren is an umlsterm, Energiestoffwechsels is an umlsterm, Wachstums is an umlsterm
|
ZfuerRheumatologie.0059i0i6.ger.abstr_task0
|
Sentence: Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
"B-umlsterm",
"O",
"O",
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"B-umlsterm",
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"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
|
[
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[
"umlsterm"
] |
Glukokortikoide is an umlsterm, Geweben is an umlsterm, Saeugetieren is an umlsterm, Energiestoffwechsels is an umlsterm, Wachstums is an umlsterm
|
ZfuerRheumatologie.0059i0i6.ger.abstr_task1
|
Sentence: Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
Instructions: please typing these entity words according to sentence: Glukokortikoide, Geweben, Saeugetieren, Energiestoffwechsels, Wachstums
Options: umlsterm
|
[
"B-umlsterm",
"O",
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"O",
"O",
"B-umlsterm",
"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
|
[
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[
"umlsterm"
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Glukokortikoide, Geweben, Saeugetieren, Energiestoffwechsels, Wachstums
|
ZfuerRheumatologie.0059i0i6.ger.abstr_task2
|
Sentence: Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
Instructions: please extract entity words from the input sentence
|
[
"B-umlsterm",
"O",
"O",
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"O",
"O",
"B-umlsterm",
"O",
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"O",
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"O",
"B-umlsterm",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
] |
Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung .
|
[
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[
"umlsterm"
] |
AMPA receptor is a GENE-N, [ 3H]LY395153 is a CHEMICAL, AMPA receptors is a GENE-N
|
11406192_task0
|
Sentence: Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: GENE-N, CHEMICAL
|
[
"O",
"O",
"O",
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"I-GENE-N",
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"I-CHEMICAL",
"O",
"O",
"O",
"O",
"O",
"B-GENE-N",
"I-GENE-N",
"O"
] |
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
|
[
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[
"GENE-N",
"CHEMICAL",
"GENE-Y"
] |
AMPA receptor is a GENE-N, [ 3H]LY395153 is a CHEMICAL, AMPA receptors is a GENE-N
|
11406192_task1
|
Sentence: Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
Instructions: please typing these entity words according to sentence: AMPA receptor, [ 3H]LY395153, AMPA receptors
Options: GENE-N, CHEMICAL
|
[
"O",
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"I-CHEMICAL",
"O",
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"O",
"O",
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"O"
] |
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
|
[
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[
"GENE-N",
"CHEMICAL",
"GENE-Y"
] |
AMPA receptor, [ 3H]LY395153, AMPA receptors
|
11406192_task2
|
Sentence: Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
Instructions: please extract entity words from the input sentence
|
[
"O",
"O",
"O",
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"I-GENE-N",
"O",
"O",
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"I-CHEMICAL",
"O",
"O",
"O",
"O",
"O",
"B-GENE-N",
"I-GENE-N",
"O"
] |
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.
|
[
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[
"GENE-N",
"CHEMICAL",
"GENE-Y"
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Praevalenzraten is an umlsterm, Praevalenzraten is an umlsterm, Faehigkeiten is an umlsterm, Testleistungen is an umlsterm, Einkommensniveau is an umlsterm
|
DerNervenarzt.80690975.ger.abstr_task0
|
Sentence: Mit dem Terminus " leichte kognitive Beeintraechtigung im Alter " werden kognitive Defizite bezeichnet , die ueber normale Altersbegleiterscheinungen hinausgehen , aber nicht an den Schweregrad einer dementiellen Erkrankung heranreichen . Anhand der Daten von 202 gesunden 60- bis 64jaehrigen Teilnehmern der Interdisziplinaeren Langzeitstudie fuer Erwachsene ( ILSE ) wurden die Praevalenzraten von 4 aktuellen Konzepten der leichten kognitiven Beeintraechtigung verglichen sowie Zusammenhaenge mit moeglichen soziodemographischen und psychologischen Merkmalen untersucht . Die Praevalenzraten betrugen fuer age-associated memory impairment " " 13,5% , fuer age-consistent memory impairment " " 6,5% , fuer late-life forgetfulness " 1,5% " und fuer aging associated cognitive decline " 23,5% . " Es fand sich kein Zusammenhang zwischen den subjektiven Angaben ueber nachlassende kognitive Faehigkeiten und den Ergebnissen der neuropsychologischen Testungen . Dagegen bestanden Zusammenhaenge zwischen subjektiven Beschwerden und psychologischen Variablen wie Depressivitaet und Neurotizismus sowie zwischen niedrigeren Testleistungen und soziodemographischen Variablen wie geringerem Bildungsgrad und Einkommensniveau . Der praediktive Wert der hier untersuchten Konzepte kann erst durch Langzeitstudien definitiv beurteilt werden .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
|
[
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"B-umlsterm",
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Mit dem Terminus " leichte kognitive Beeintraechtigung im Alter " werden kognitive Defizite bezeichnet , die ueber normale Altersbegleiterscheinungen hinausgehen , aber nicht an den Schweregrad einer dementiellen Erkrankung heranreichen . Anhand der Daten von 202 gesunden 60- bis 64jaehrigen Teilnehmern der Interdisziplinaeren Langzeitstudie fuer Erwachsene ( ILSE ) wurden die Praevalenzraten von 4 aktuellen Konzepten der leichten kognitiven Beeintraechtigung verglichen sowie Zusammenhaenge mit moeglichen soziodemographischen und psychologischen Merkmalen untersucht . Die Praevalenzraten betrugen fuer age-associated memory impairment " " 13,5% , fuer age-consistent memory impairment " " 6,5% , fuer late-life forgetfulness " 1,5% " und fuer aging associated cognitive decline " 23,5% . " Es fand sich kein Zusammenhang zwischen den subjektiven Angaben ueber nachlassende kognitive Faehigkeiten und den Ergebnissen der neuropsychologischen Testungen . Dagegen bestanden Zusammenhaenge zwischen subjektiven Beschwerden und psychologischen Variablen wie Depressivitaet und Neurotizismus sowie zwischen niedrigeren Testleistungen und soziodemographischen Variablen wie geringerem Bildungsgrad und Einkommensniveau . Der praediktive Wert der hier untersuchten Konzepte kann erst durch Langzeitstudien definitiv beurteilt werden .
|
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[
"umlsterm"
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Praevalenzraten is an umlsterm, Praevalenzraten is an umlsterm, Faehigkeiten is an umlsterm, Testleistungen is an umlsterm, Einkommensniveau is an umlsterm
|
DerNervenarzt.80690975.ger.abstr_task1
|
Sentence: Mit dem Terminus " leichte kognitive Beeintraechtigung im Alter " werden kognitive Defizite bezeichnet , die ueber normale Altersbegleiterscheinungen hinausgehen , aber nicht an den Schweregrad einer dementiellen Erkrankung heranreichen . Anhand der Daten von 202 gesunden 60- bis 64jaehrigen Teilnehmern der Interdisziplinaeren Langzeitstudie fuer Erwachsene ( ILSE ) wurden die Praevalenzraten von 4 aktuellen Konzepten der leichten kognitiven Beeintraechtigung verglichen sowie Zusammenhaenge mit moeglichen soziodemographischen und psychologischen Merkmalen untersucht . Die Praevalenzraten betrugen fuer age-associated memory impairment " " 13,5% , fuer age-consistent memory impairment " " 6,5% , fuer late-life forgetfulness " 1,5% " und fuer aging associated cognitive decline " 23,5% . " Es fand sich kein Zusammenhang zwischen den subjektiven Angaben ueber nachlassende kognitive Faehigkeiten und den Ergebnissen der neuropsychologischen Testungen . Dagegen bestanden Zusammenhaenge zwischen subjektiven Beschwerden und psychologischen Variablen wie Depressivitaet und Neurotizismus sowie zwischen niedrigeren Testleistungen und soziodemographischen Variablen wie geringerem Bildungsgrad und Einkommensniveau . Der praediktive Wert der hier untersuchten Konzepte kann erst durch Langzeitstudien definitiv beurteilt werden .
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Options: umlsterm
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Mit dem Terminus " leichte kognitive Beeintraechtigung im Alter " werden kognitive Defizite bezeichnet , die ueber normale Altersbegleiterscheinungen hinausgehen , aber nicht an den Schweregrad einer dementiellen Erkrankung heranreichen . Anhand der Daten von 202 gesunden 60- bis 64jaehrigen Teilnehmern der Interdisziplinaeren Langzeitstudie fuer Erwachsene ( ILSE ) wurden die Praevalenzraten von 4 aktuellen Konzepten der leichten kognitiven Beeintraechtigung verglichen sowie Zusammenhaenge mit moeglichen soziodemographischen und psychologischen Merkmalen untersucht . Die Praevalenzraten betrugen fuer age-associated memory impairment " " 13,5% , fuer age-consistent memory impairment " " 6,5% , fuer late-life forgetfulness " 1,5% " und fuer aging associated cognitive decline " 23,5% . " Es fand sich kein Zusammenhang zwischen den subjektiven Angaben ueber nachlassende kognitive Faehigkeiten und den Ergebnissen der neuropsychologischen Testungen . Dagegen bestanden Zusammenhaenge zwischen subjektiven Beschwerden und psychologischen Variablen wie Depressivitaet und Neurotizismus sowie zwischen niedrigeren Testleistungen und soziodemographischen Variablen wie geringerem Bildungsgrad und Einkommensniveau . Der praediktive Wert der hier untersuchten Konzepte kann erst durch Langzeitstudien definitiv beurteilt werden .
|
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