bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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tazarotene	12942109_task2	Sentence: A phase 1 study of tazarotene in adults with advanced cancer. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O" ]	A phase 1 study of tazarotene in adults with advanced cancer.	[ "A", "phase", "1", "study", "of", "tazarotene", "in", "adults", "with", "advanced", "cancer", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Chloe is a NOMBRE_SUJETO_ASISTENCIA, Villanueva Marin is a NOMBRE_SUJETO_ASISTENCIA, 3785612 is a ID_SUJETO_ASISTENCIA, Calle Fernando Higueras , 27 is a CALLE, Las Palmas is a TERRITORIO, 35016 is a TERRITORIO, 27/03/2016 is a FECHAS, España is a PAIS, 8 dias is a EDAD_SUJETO_ASISTENCIA, 04/04/2016 is a FECHAS, 4375656 is a ID_CONTACTO_ASISTENCIAL, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, 35 35 20015 is a ID_TITULACION_PERSONAL_SANITARIO, Lactante is a ID_SUJETO_ASISTENCIA, ocho días is a EDAD_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, primera hija is a ID_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, dos días is a EDAD_SUJETO_ASISTENCIA, ocho meses is a EDAD_SUJETO_ASISTENCIA, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, Complejo Hospitalario Universitario Insular - Materno Infantil is a HOSPITAL, Avda . Marítima del Sur , sn is a CALLE, 35016 is a TERRITORIO, Las Palmas de Gran Canaria is a TERRITORIO, Islas Canarias is a TERRITORIO, España is a PAIS, aidacost@hotmail.com is a CORREO_ELECTRONICO	467_task0	Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO	[ "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "O", "O", "O", "O", "B-TERRITORIO", "I-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ID_CONTACTO_ASISTENCIAL", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "O", "B-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "B-TERRITORIO", "B-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "B-TERRITORIO", "I-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. 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Chloe is a NOMBRE_SUJETO_ASISTENCIA, Villanueva Marin is a NOMBRE_SUJETO_ASISTENCIA, 3785612 is a ID_SUJETO_ASISTENCIA, Calle Fernando Higueras , 27 is a CALLE, Las Palmas is a TERRITORIO, 35016 is a TERRITORIO, 27/03/2016 is a FECHAS, España is a PAIS, 8 dias is a EDAD_SUJETO_ASISTENCIA, 04/04/2016 is a FECHAS, 4375656 is a ID_CONTACTO_ASISTENCIAL, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, 35 35 20015 is a ID_TITULACION_PERSONAL_SANITARIO, Lactante is a ID_SUJETO_ASISTENCIA, ocho días is a EDAD_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, primera hija is a ID_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, dos días is a EDAD_SUJETO_ASISTENCIA, ocho meses is a EDAD_SUJETO_ASISTENCIA, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, Complejo Hospitalario Universitario Insular - Materno Infantil is a HOSPITAL, Avda . Marítima del Sur , sn is a CALLE, 35016 is a TERRITORIO, Las Palmas de Gran Canaria is a TERRITORIO, Islas Canarias is a TERRITORIO, España is a PAIS, aidacost@hotmail.com is a CORREO_ELECTRONICO	467_task1	Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please typing these entity words according to sentence: Chloe, Villanueva Marin, 3785612, Calle Fernando Higueras , 27, Las Palmas, 35016, 27/03/2016, España, 8 dias, 04/04/2016, 4375656, Aída Acosta Arencibia, 35 35 20015, Lactante, ocho días, padres, primera hija, padres, dos días, ocho meses, Aída Acosta Arencibia, Complejo Hospitalario Universitario Insular - Materno Infantil, Avda . 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Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. 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Chloe, Villanueva Marin, 3785612, Calle Fernando Higueras , 27, Las Palmas, 35016, 27/03/2016, España, 8 dias, 04/04/2016, 4375656, Aída Acosta Arencibia, 35 35 20015, Lactante, ocho días, padres, primera hija, padres, dos días, ocho meses, Aída Acosta Arencibia, Complejo Hospitalario Universitario Insular - Materno Infantil, Avda . Marítima del Sur , sn, 35016, Las Palmas de Gran Canaria, Islas Canarias, España, aidacost@hotmail.com	467_task2	Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "O", "O", "O", "O", "B-TERRITORIO", "I-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ID_CONTACTO_ASISTENCIAL", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "O", "O", "B-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "I-HOSPITAL", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "O", "B-TERRITORIO", "B-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "I-TERRITORIO", "B-TERRITORIO", "I-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com	[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", "Chloe", ".", "\n", "Apellidos", ":", "Villanueva", "Marin", ".", "\n", "NHC", ":", "3785612", ".", "\n", "Domicilio", ":", "Calle", "Fernando", "Higueras", ",", "27", ".", "\n", "Localidad/", "Provincia", ":", "Las", "Palmas", ".", "\n", "CP", ":", "35016", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "27/03/2016", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "8", "dias", "Sexo", ":", "M.", "\n", "Fecha", "de", "Ingreso", ":", "04/04/2016", ".", "\n", "Servicio", ":", "Cirugía", "Plástica", ".", "\n", "Episodio", ":", "4375656", ".", "\n", "Médico", ":", "Aída", "Acosta", "Arencibia", " ", "NºCol", ":", "35", "35", "20015", ".", "\n", "Historia", "Actual", ":", "Lactante", "de", "ocho", "días", "cuyos", "padres", "consultan", "por", "ombligo", "poco", "cicatrizado", ".", "Como", "antecedentes", "personales", ",", "se", "trata", "de", "la", "primera", "hija", "de", "padres", "sanos", ".", "Nacida", "a", "las", "39", "semanas", "de", "gestación", "por", "parto", "eutócico", ";", "Apgar", "9/10", ",", "peso", "2830", "gramos", ".", "No", "refieren", "antecedentes", "de", "interés", ",", "ni", "aportan", "el", "informe", "hospitalario", ".", "\n", "En", "la", "exploración", "se", "aprecia", "una", "implantación", "amplia", "del", "cordón", "umbilical", ",", "que", "tiene", "aspecto", "mucoso", ",", "y", "un", "pequeño", "desgarro", "en", "la", "base", "del", "mismo", ",", "sin", "signos", "de", "infección", "local", ".", "El", "resto", "de", "la", "exploración", "física", "es", "normal", ".", "No", "refiere", "ninguna", "manifestación", "clínica", "acompañante", ".", "Se", "aplica", "nitrato", "de", "plata", "y", "se", "cita", "para", "su", "control", "en", "48", "horas", ".", "\n", "En", "la", "visita", "de", "control", "aportan", "el", "informe", "de", "alta", "tras", "el", "nacimiento", ".", "Refleja", "que", "el", "cordón", "umbilical", "presentaba", "un", "quiste", ",", "diagnosticado", "en", "la", "ecografía", "prenatal", "del", "segundo", "trimestre", "y", "descrito", "como", "quiste", "de", "gelatina", "de", "Wharton", "de", "49", "x", "39", "mm", ".", "Al", "nacimiento", "fue", "valorada", "por", "un", "cirujano", ",", "que", "colocó", "una", "pinza", "proximal", "al", "quiste", ",", "que", "fue", "resecado", ".", "A", "los", "dos", "días", "de", "vida", "realizan", "una", "ecografía", "abdominal", "que", "fue", "normal", ".", "Durante", "el", "ingreso", "permaneció", "asintomática", "y", "dan", "el", "alta", "con", "normalidad", "clínica", ",", "excepto", "por", "un", "pequeño", "desgarro", "en", "base", "del", "cordón", ",", "que", "no", "presenta", "complicaciones", ".", "\n", "En", "la", "visita", "de", "control", "ambulatorio", "se", "observa", "una", "salida", "abundante", "de", "líquido", "claro", "del", "centro", "del", "ombligo", ",", "sin", "signos", "de", "infección", ".", "Se", "deriva", "para", "valoración", "por", "cirugía", "pediátrica", ".", "El", "cirujano", "liga", "el", "cordón", "umbilical", ",", "que", "está", "casi", "desprendido", "y", "con", "aspecto", "húmedo", ".", "Se", "comprueba", "la", "existencia", "de", "un", "trayecto", "fistuloso", ".", "Una", "nueva", "ecografía", "abdominal", "pone", "de", "manifiesto", "una", "estructura", "tubular", "tortuosa", "que", "comunica", "con", "la", "pared", "vesical", "superior", "y", "se", "diagnóstica", "de", "persistencia", "del", "uraco", "(", "tipo", "uraco", "permeable", ")", "y", "se", "decide", "observación", "y", "revaloración", "posterior", ".", "A", "los", "ocho", "meses", "de", "vida", "se", "ha", "producido", "el", "cierre", "espontáneo", ",", "y", "en", "los", "controles", "posteriores", "se", "evidencia", "la", "ausencia", "de", "la", "permeabilidad", "del", "uraco", ".", "\n", "Remitido", "por", ":", " ", "Dra", ".", "Aída", "Acosta", "Arencibia", "Servicio", "de", "Cirugía", "Plástica", "Complejo", "Hospitalario", "Universitario", "Insular", "-", "Materno", "Infantil", "Avda", ".", "Marítima", "del", "Sur", ",", "sn", ".", "35016", "Las", "Palmas", "de", "Gran", "Canaria", "Islas", "Canarias", ".", "España", "e", "-", "mail", ":", "aidacost@hotmail.com", "\n" ]	[ "HOSPITAL", "CALLE", "TERRITORIO", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "NOMBRE_SUJETO_ASISTENCIA", "ID_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "EDAD_SUJETO_ASISTENCIA", "FECHAS", "ID_CONTACTO_ASISTENCIAL", "PAIS", "FAMILIARES_SUJETO_ASISTENCIA", "SEXO_SUJETO_ASISTENCIA" ]
3 -15 years is a Value, old is a Person, Clinical symptoms suggestive of is a Mood, pharyngitis is a Condition, MC Isaac score is a Measurement, =3 is a Value, Rapid - antigen detection test is a Measurement, RADT is a Measurement, positive is a Value, GAS- is a Qualifier	NCT03264911_inc_task0	Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Measurement, Mood	[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form	[ "3", "-15", "years", "old", "\n", "Clinical", "symptoms", "suggestive", "of", "pharyngitis", "with", "MC", "Isaac", "score", "=3", "\n", "Rapid", "-", "antigen", "detection", "test", "(", "RADT", ")", "positive", "for", "GAS-", "\n", "Signed", "informed", "parental", "/", "patient", "consent", "form", "\n" ]	[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]
3 -15 years is a Value, old is a Person, Clinical symptoms suggestive of is a Mood, pharyngitis is a Condition, MC Isaac score is a Measurement, =3 is a Value, Rapid - antigen detection test is a Measurement, RADT is a Measurement, positive is a Value, GAS- is a Qualifier	NCT03264911_inc_task1	Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please typing these entity words according to sentence: 3 -15 years, old, Clinical symptoms suggestive of, pharyngitis, MC Isaac score, =3, Rapid - antigen detection test, RADT, positive, GAS- Options: Condition, Qualifier, Value, Person, Measurement, Mood	[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form	[ "3", "-15", "years", "old", "\n", "Clinical", "symptoms", "suggestive", "of", "pharyngitis", "with", "MC", "Isaac", "score", "=3", "\n", "Rapid", "-", "antigen", "detection", "test", "(", "RADT", ")", "positive", "for", "GAS-", "\n", "Signed", "informed", "parental", "/", "patient", "consent", "form", "\n" ]	[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]
3 -15 years, old, Clinical symptoms suggestive of, pharyngitis, MC Isaac score, =3, Rapid - antigen detection test, RADT, positive, GAS-	NCT03264911_inc_task2	Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please extract entity words from the input sentence	[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form	[ "3", "-15", "years", "old", "\n", "Clinical", "symptoms", "suggestive", "of", "pharyngitis", "with", "MC", "Isaac", "score", "=3", "\n", "Rapid", "-", "antigen", "detection", "test", "(", "RADT", ")", "positive", "for", "GAS-", "\n", "Signed", "informed", "parental", "/", "patient", "consent", "form", "\n" ]	[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]
Stent is an umlsterm, implantation is an umlsterm, aneurysms is an umlsterm, postmortem examinations is an umlsterm, Measurements is an umlsterm, criteria is an umlsterm, necks is an umlsterm, aneurysms is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, neck is an umlsterm, necks is an umlsterm, stent is an umlsterm, morphological is an umlsterm, neck is an umlsterm, Tube - Stent is an umlsterm, neck is an umlsterm, stent is an umlsterm, aneurysms is an umlsterm, stent is an umlsterm, implantation is an umlsterm, ulcerations is an umlsterm, secondary is an umlsterm, thrombi is an umlsterm, para - aneurysmal is an umlsterm, findings is an umlsterm, transport is an umlsterm, prosthesis is an umlsterm, implantation is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, aorta is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task0	Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .	[ "In", "view", "of", "a", "possible", "Stent", "implantation", ",", "20", "infrarenal", "abdominal", "aneurysms", "obtained", "consecutively", "during", "postmortem", "examinations", "were", "investigated", ".", "Measurements", "were", "performed", "according", "to", "toporegional", "criteria", "on", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysms", "as", "well", "as", "on", "their", "lengths", "and", "diameters", ".", "Then", "we", "correlated", "the", "extent", "of", "the", "proximal", "and", "distal", "necks", "to", "the", "aneurysmal", "lengths", "and", "diameters", ",", "respectively", ".", "The", "following", "results", "were", "obtained", ":", "1", ".", "Depending", "on", "the", "increase", "in", "length", "of", "the", "infrarenal", "abdominal", "aneurysm", ",", "there", "is", "an", "inproportional", "shortening", "of", "the", "proximal", "and", "distal", "neck", ".", "Up", "to", "an", "aneurysmal", "length", "of", "4", "cm", "both", "proximal", "and", "distant", "necks", "are", "suitable", "for", "stent", "fixation", "in", "all", "cases", ".", "2", ".", "With", "lengths", "of", "more", "than", "4", "cm", "according", "to", "the", "morphological", "results", ",", "the", "distal", "neck", "is", "almost", "always", "unsuitable", "for", "fixation", "of", "a", "simple", "Tube", "-", "Stent", ".", "3", ".", "The", "proximal", "neck", "is", "suitable", "for", "stent", "fixation", "in", "all", "cases", "up", "to", "an", "aneurysmal", "length", "of", "10", "cm", ".", "For", "longer", "aneurysms", ",", "only", "a", "quarter", "of", "all", "cases", "is", "suitable", "for", "stent", "implantation", ".", "In", "all", "cases", "investigated", "there", "were", "severe", "arteriosclerotic", "changes", "with", "atheromatous", "ulcerations", "and", "secondary", "wall", "-", "adherent", "thrombi", "of", "up", "to", "three", "centimeter", "thickness", "in", "the", "aneurysmal", "and", "para", "-", "aneurysmal", "regions", ".", "These", "findings", "have", "to", "be", "considered", ",", "with", "respect", "to", "the", "transluminal", "transport", "of", "the", "prosthesis", "as", "well", "as", "in", "the", "regions", "of", "the", "supposed", "implantation", "in", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysm", "with", "individually", "variable", "arteriosclerotic", "changes", "of", "the", "aorta", "." ]	[ "umlsterm" ]
Stent is an umlsterm, implantation is an umlsterm, aneurysms is an umlsterm, postmortem examinations is an umlsterm, Measurements is an umlsterm, criteria is an umlsterm, necks is an umlsterm, aneurysms is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, neck is an umlsterm, necks is an umlsterm, stent is an umlsterm, morphological is an umlsterm, neck is an umlsterm, Tube - Stent is an umlsterm, neck is an umlsterm, stent is an umlsterm, aneurysms is an umlsterm, stent is an umlsterm, implantation is an umlsterm, ulcerations is an umlsterm, secondary is an umlsterm, thrombi is an umlsterm, para - aneurysmal is an umlsterm, findings is an umlsterm, transport is an umlsterm, prosthesis is an umlsterm, implantation is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, aorta is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task1	Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please typing these entity words according to sentence: Stent, implantation, aneurysms, postmortem examinations, Measurements, criteria, necks, aneurysms, necks, aneurysm, neck, necks, stent, morphological, neck, Tube - Stent, neck, stent, aneurysms, stent, implantation, ulcerations, secondary, thrombi, para - aneurysmal, findings, transport, prosthesis, implantation, necks, aneurysm, aorta Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .	[ "In", "view", "of", "a", "possible", "Stent", "implantation", ",", "20", "infrarenal", "abdominal", "aneurysms", "obtained", "consecutively", "during", "postmortem", "examinations", "were", "investigated", ".", "Measurements", "were", "performed", "according", "to", "toporegional", "criteria", "on", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysms", "as", "well", "as", "on", "their", "lengths", "and", "diameters", ".", "Then", "we", "correlated", "the", "extent", "of", "the", "proximal", "and", "distal", "necks", "to", "the", "aneurysmal", "lengths", "and", "diameters", ",", "respectively", ".", "The", "following", "results", "were", "obtained", ":", "1", ".", "Depending", "on", "the", "increase", "in", "length", "of", "the", "infrarenal", "abdominal", "aneurysm", ",", "there", "is", "an", "inproportional", "shortening", "of", "the", "proximal", "and", "distal", "neck", ".", "Up", "to", "an", "aneurysmal", "length", "of", "4", "cm", "both", "proximal", "and", "distant", "necks", "are", "suitable", "for", "stent", "fixation", "in", "all", "cases", ".", "2", ".", "With", "lengths", "of", "more", "than", "4", "cm", "according", "to", "the", "morphological", "results", ",", "the", "distal", "neck", "is", "almost", "always", "unsuitable", "for", "fixation", "of", "a", "simple", "Tube", "-", "Stent", ".", "3", ".", "The", "proximal", "neck", "is", "suitable", "for", "stent", "fixation", "in", "all", "cases", "up", "to", "an", "aneurysmal", "length", "of", "10", "cm", ".", "For", "longer", "aneurysms", ",", "only", "a", "quarter", "of", "all", "cases", "is", "suitable", "for", "stent", "implantation", ".", "In", "all", "cases", "investigated", "there", "were", "severe", "arteriosclerotic", "changes", "with", "atheromatous", "ulcerations", "and", "secondary", "wall", "-", "adherent", "thrombi", "of", "up", "to", "three", "centimeter", "thickness", "in", "the", "aneurysmal", "and", "para", "-", "aneurysmal", "regions", ".", "These", "findings", "have", "to", "be", "considered", ",", "with", "respect", "to", "the", "transluminal", "transport", "of", "the", "prosthesis", "as", "well", "as", "in", "the", "regions", "of", "the", "supposed", "implantation", "in", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysm", "with", "individually", "variable", "arteriosclerotic", "changes", "of", "the", "aorta", "." ]	[ "umlsterm" ]
Stent, implantation, aneurysms, postmortem examinations, Measurements, criteria, necks, aneurysms, necks, aneurysm, neck, necks, stent, morphological, neck, Tube - Stent, neck, stent, aneurysms, stent, implantation, ulcerations, secondary, thrombi, para - aneurysmal, findings, transport, prosthesis, implantation, necks, aneurysm, aorta	ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task2	Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .	[ "In", "view", "of", "a", "possible", "Stent", "implantation", ",", "20", "infrarenal", "abdominal", "aneurysms", "obtained", "consecutively", "during", "postmortem", "examinations", "were", "investigated", ".", "Measurements", "were", "performed", "according", "to", "toporegional", "criteria", "on", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysms", "as", "well", "as", "on", "their", "lengths", "and", "diameters", ".", "Then", "we", "correlated", "the", "extent", "of", "the", "proximal", "and", "distal", "necks", "to", "the", "aneurysmal", "lengths", "and", "diameters", ",", "respectively", ".", "The", "following", "results", "were", "obtained", ":", "1", ".", "Depending", "on", "the", "increase", "in", "length", "of", "the", "infrarenal", "abdominal", "aneurysm", ",", "there", "is", "an", "inproportional", "shortening", "of", "the", "proximal", "and", "distal", "neck", ".", "Up", "to", "an", "aneurysmal", "length", "of", "4", "cm", "both", "proximal", "and", "distant", "necks", "are", "suitable", "for", "stent", "fixation", "in", "all", "cases", ".", "2", ".", "With", "lengths", "of", "more", "than", "4", "cm", "according", "to", "the", "morphological", "results", ",", "the", "distal", "neck", "is", "almost", "always", "unsuitable", "for", "fixation", "of", "a", "simple", "Tube", "-", "Stent", ".", "3", ".", "The", "proximal", "neck", "is", "suitable", "for", "stent", "fixation", "in", "all", "cases", "up", "to", "an", "aneurysmal", "length", "of", "10", "cm", ".", "For", "longer", "aneurysms", ",", "only", "a", "quarter", "of", "all", "cases", "is", "suitable", "for", "stent", "implantation", ".", "In", "all", "cases", "investigated", "there", "were", "severe", "arteriosclerotic", "changes", "with", "atheromatous", "ulcerations", "and", "secondary", "wall", "-", "adherent", "thrombi", "of", "up", "to", "three", "centimeter", "thickness", "in", "the", "aneurysmal", "and", "para", "-", "aneurysmal", "regions", ".", "These", "findings", "have", "to", "be", "considered", ",", "with", "respect", "to", "the", "transluminal", "transport", "of", "the", "prosthesis", "as", "well", "as", "in", "the", "regions", "of", "the", "supposed", "implantation", "in", "the", "proximal", "and", "distal", "necks", "of", "the", "aneurysm", "with", "individually", "variable", "arteriosclerotic", "changes", "of", "the", "aorta", "." ]	[ "umlsterm" ]
Angst is an umlsterm, Diagnose is an umlsterm, Aengste is an umlsterm, Aengsten is an umlsterm, Patienten is an umlsterm, depression is an umlsterm, Konzeption is an umlsterm, Therapie is an umlsterm, Depressionen is an umlsterm	DerNervenarzt.80690956.ger.abstr_task0	Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .	[ "Nach", "einer", "Darstellung", "der", "Symptomatologie", "des", "depressiven", "Wahns", "werden", "die", "einzelnen", "Themen", ",", "ihre", "Beziehungen", "zum", "depressiven", "Schulderleben", "und", "zur", "depressiven", "Angst", "sowie", "ihre", "Abgrenzung", "eroertert", ".", "Schuldwahn", "Armutswahn", "und", "Krankheitswahn", ",", "sind", "einschliesslich", "ihrer", "Vorstufen", "keineswegs", "seltene", "Symptome", ",", "die", "fuer", "die", "Diagnose", "Major", "depressive", "disorder", "/", "endogene", "Depression", "/", "Melancholie", "beweisend", "sind", ".", "Die", "Vorstufen", ",", "naemlich", "Verschuldungs-", ",", "Verarmungs-", "und", "hypochondrische", "Aengste", "sind", "ebenfalls", "charakteristische", "Symptome", ",", "die", "sich", "von", "den", "Aengsten", "der", "Patienten", "mit", "neurotischen", "Depressionen", "/", "Dysthymia", "mit", "hoher", "Trennschaerfe", "abgrenzen", "lassen", ".", "Delusional", "depression", "erwies", "sich", "zwar", "nicht", "als", "eine", "Krankheitseinheit", ",", "die", "Konzeption", "aber", "war", "von", "heuristischer", "Bedeutung", "im", "Hinblick", "auf", "die", "Therapie", ".", "Dem", "besonderen", "Schwere-", "und", "Auspraegungsgrad", "dieser", "Depressionen", "entsprechen", "spezielle", "therapeutische", "Vorgehensweisen", "." ]	[ "umlsterm" ]
Angst is an umlsterm, Diagnose is an umlsterm, Aengste is an umlsterm, Aengsten is an umlsterm, Patienten is an umlsterm, depression is an umlsterm, Konzeption is an umlsterm, Therapie is an umlsterm, Depressionen is an umlsterm	DerNervenarzt.80690956.ger.abstr_task1	Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please typing these entity words according to sentence: Angst, Diagnose, Aengste, Aengsten, Patienten, depression, Konzeption, Therapie, Depressionen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .	[ "Nach", "einer", "Darstellung", "der", "Symptomatologie", "des", "depressiven", "Wahns", "werden", "die", "einzelnen", "Themen", ",", "ihre", "Beziehungen", "zum", "depressiven", "Schulderleben", "und", "zur", "depressiven", "Angst", "sowie", "ihre", "Abgrenzung", "eroertert", ".", "Schuldwahn", "Armutswahn", "und", "Krankheitswahn", ",", "sind", "einschliesslich", "ihrer", "Vorstufen", "keineswegs", "seltene", "Symptome", ",", "die", "fuer", "die", "Diagnose", "Major", "depressive", "disorder", "/", "endogene", "Depression", "/", "Melancholie", "beweisend", "sind", ".", "Die", "Vorstufen", ",", "naemlich", "Verschuldungs-", ",", "Verarmungs-", "und", "hypochondrische", "Aengste", "sind", "ebenfalls", "charakteristische", "Symptome", ",", "die", "sich", "von", "den", "Aengsten", "der", "Patienten", "mit", "neurotischen", "Depressionen", "/", "Dysthymia", "mit", "hoher", "Trennschaerfe", "abgrenzen", "lassen", ".", "Delusional", "depression", "erwies", "sich", "zwar", "nicht", "als", "eine", "Krankheitseinheit", ",", "die", "Konzeption", "aber", "war", "von", "heuristischer", "Bedeutung", "im", "Hinblick", "auf", "die", "Therapie", ".", "Dem", "besonderen", "Schwere-", "und", "Auspraegungsgrad", "dieser", "Depressionen", "entsprechen", "spezielle", "therapeutische", "Vorgehensweisen", "." ]	[ "umlsterm" ]
Angst, Diagnose, Aengste, Aengsten, Patienten, depression, Konzeption, Therapie, Depressionen	DerNervenarzt.80690956.ger.abstr_task2	Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .	[ "Nach", "einer", "Darstellung", "der", "Symptomatologie", "des", "depressiven", "Wahns", "werden", "die", "einzelnen", "Themen", ",", "ihre", "Beziehungen", "zum", "depressiven", "Schulderleben", "und", "zur", "depressiven", "Angst", "sowie", "ihre", "Abgrenzung", "eroertert", ".", "Schuldwahn", "Armutswahn", "und", "Krankheitswahn", ",", "sind", "einschliesslich", "ihrer", "Vorstufen", "keineswegs", "seltene", "Symptome", ",", "die", "fuer", "die", "Diagnose", "Major", "depressive", "disorder", "/", "endogene", "Depression", "/", "Melancholie", "beweisend", "sind", ".", "Die", "Vorstufen", ",", "naemlich", "Verschuldungs-", ",", "Verarmungs-", "und", "hypochondrische", "Aengste", "sind", "ebenfalls", "charakteristische", "Symptome", ",", "die", "sich", "von", "den", "Aengsten", "der", "Patienten", "mit", "neurotischen", "Depressionen", "/", "Dysthymia", "mit", "hoher", "Trennschaerfe", "abgrenzen", "lassen", ".", "Delusional", "depression", "erwies", "sich", "zwar", "nicht", "als", "eine", "Krankheitseinheit", ",", "die", "Konzeption", "aber", "war", "von", "heuristischer", "Bedeutung", "im", "Hinblick", "auf", "die", "Therapie", ".", "Dem", "besonderen", "Schwere-", "und", "Auspraegungsgrad", "dieser", "Depressionen", "entsprechen", "spezielle", "therapeutische", "Vorgehensweisen", "." ]	[ "umlsterm" ]
Retinoid is a CHEMICAL	2922761_task0	Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.	[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Retinoid is a CHEMICAL	2922761_task1	Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please typing these entity words according to sentence: Retinoid Options: CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.	[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Retinoid	2922761_task2	Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.	[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
autistic is a Participant_Condition, children ' s is a Participant_Age, Thai Traditional Massage ( TTM ) is a Intervention_Educational, 60 is a Participant_Sample-size, 3 and 10 is a Participant_Age, Standard sensory integration therapy ( SI ) is a Intervention_Educational, major behavior disturbances is a Outcome_Mental, Conners ' Rating Scales is a Outcome_Mental, Sleep Diary ( SD ) is a Outcome_Mental, Sixty ( 60 ) is a Participant_Sample-size, 4.67 + /- 1.82 is a Participant_Age, Conners ' Teacher Questionnaire is a Outcome_Mental, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior is a Outcome_Mental, Conners ' Parent Questionnaire is a Outcome_Mental, anxiety is a Outcome_Physical, stereotypical behaviors is a Outcome_Mental	43283_task0	Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . 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OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .	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autistic is a Participant_Condition, children ' s is a Participant_Age, Thai Traditional Massage ( TTM ) is a Intervention_Educational, 60 is a Participant_Sample-size, 3 and 10 is a Participant_Age, Standard sensory integration therapy ( SI ) is a Intervention_Educational, major behavior disturbances is a Outcome_Mental, Conners ' Rating Scales is a Outcome_Mental, Sleep Diary ( SD ) is a Outcome_Mental, Sixty ( 60 ) is a Participant_Sample-size, 4.67 + /- 1.82 is a Participant_Age, Conners ' Teacher Questionnaire is a Outcome_Mental, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior is a Outcome_Mental, Conners ' Parent Questionnaire is a Outcome_Mental, anxiety is a Outcome_Physical, stereotypical behaviors is a Outcome_Mental	43283_task1	Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . 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OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .	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autistic, children ' s, Thai Traditional Massage ( TTM ), 60, 3 and 10, Standard sensory integration therapy ( SI ), major behavior disturbances, Conners ' Rating Scales, Sleep Diary ( SD ), Sixty ( 60 ), 4.67 + /- 1.82, Conners ' Teacher Questionnaire, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior, Conners ' Parent Questionnaire, anxiety, stereotypical behaviors	43283_task2	Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .	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topical and / or systemic medication or mechanical devices is a Scope, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses is a Scope, females is a Person, active sexual life is a Observation, not is a Negation, contraceptive method is a Procedure, Female is a Person, pregnant is a Condition, lactating is a Condition, Female is a Person, positive is a Value, urine pregnancy test is a Measurement, Positive drug addictions is a Condition, verbal interrogatory is a Procedure, mentally disabled is a Condition, Serious tear film dysfunction syndrome is a Condition, TBUT is a Measurement, < 5 s is a Value, Schirmer is a Measurement, < 4 mm is a Value, OSDI is a Measurement, > 30 pints is a Value, Corneal staining is a Measurement, > grade III is a Value, Oxford scale is a Qualifier, Non perforated is a Qualifier, corneal ulcer is a Condition, Perforated is a Qualifier, corneal ulcer is a Condition, Autoimmune is a Qualifier, corneal ulcer is a Condition, Ocular surface scarring diseases is a Condition, Fibro vascular proliferation lesions is a Condition, conjunctival and / or corneal surface is a Scope, pterygium is a Qualifier, Concomitant is a Temporal, chronic inflammatory diseases is a Condition, ocular structure is a Qualifier, Acute or infectious is a Scope, inflammatory disease is a Condition, Corneal disease is a Condition, potentially requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, Ocular surgical procedures is a Procedure, 3 months before the protocol inclusion is a Temporal, Treatments or procedures is a Scope, tear film dysfunction treatment is a Procedure, punctal silicone plugs is a Device, Posterior segment diseases is a Condition, requiring a treatment or threatening the visual prognosis is a Scope, Retinal diseases is a Condition, requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, History is a Observation, penetrating keratoplasty is a Procedure, Soft or hard contact lenses is a Scope, during the last month from inclusion day is a Temporal	NCT03223909_exc_task0	Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Negation, Scope, Measurement, Device, Mood	[ "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Person", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "B-Negation", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Person", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "B-Person", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Qualifier", "O", "O", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Mood", "I-Mood", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Device", "I-Device", "I-Device", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Mood", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Observation", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day	[ "Subjects", "with", "topical", "and", "/", "or", "systemic", "medication", "or", "mechanical", "devices", "that", "interfere", "determinedly", "on", "the", "results", "of", "the", "study", "(", "such", "as", "topical", "immunomodulators", ",", "punctal", "plugs", ",", "corticosteroids", ",", "preservative", "artificial", "tears", ",", "contact", "lenses", ")", ".", "\n", "Subjects", "(", "females", ")", "with", "active", "sexual", "life", "that", "do", "not", "use", "a", "contraceptive", "method", ".", "\n", "Female", "subjects", "who", "are", "pregnant", "or", "lactating", "\n", "Female", "subjects", "with", "a", "positive", "urine", "pregnancy", "test", "\n", "Positive", "drug", "addictions", "*", "(", "verbal", "interrogatory", ")", "\n", "Subjects", "who", "have", "participated", "on", "any", "other", "research", "clinical", "trials", "on", "the", "last", "40", "days", "\n", "Subjects", "legal", "or", "mentally", "disabled", "to", "give", "an", "informed", "consent", "for", "participating", "on", "this", "study", "\n", "Subjects", "who", "can't", "comply", "with", "the", "appointments", "or", "with", "every", "protocol", "requirement", ".", "\n", "Serious", "tear", "film", "dysfunction", "syndrome", "TBUT", "<", "5", "s", "Schirmer", ":", "<", "4", "mm", "OSDI", ">", "30", "pints", "Corneal", "staining", ">", "grade", "III", "on", "the", "Oxford", "scale", "\n", "Non", "perforated", "corneal", "ulcer", "\n", "Perforated", "corneal", "ulcer", "\n", "Autoimmune", "corneal", "ulcer", "\n", "Ocular", "surface", "scarring", "diseases", "\n", "Ocular", "surface", "or", "annexes", "metaplastic", "lesions", "\n", "Fibro", "vascular", "proliferation", "lesions", "on", "the", "conjunctival", "and", "/", "or", "corneal", "surface", "(", "i.e", ".", ":", "pterygium", ")", "\n", "Concomitant", "chronic", "inflammatory", "diseases", "on", "any", "ocular", "structure", "\n", "Acute", "or", "infectious", "inflammatory", "disease", "\n", "Corneal", "disease", "potentially", "requiring", "a", "treatment", "during", "the", "following", "3", "months", "\n", "Use", "of", "topical", "or", "systemic", "drug", "products", "classified", "as", "forbidden", "\n", "Ocular", "surgical", "procedures", "3", "months", "before", "the", "protocol", "inclusion", "\n", "Treatments", "or", "procedures", "indicated", "on", "the", "tear", "film", "dysfunction", "treatment", ",", "as", "punctal", "silicone", "plugs", ".", "\n", "Posterior", "segment", "diseases", "requiring", "a", "treatment", "or", "threatening", "the", "visual", "prognosis", "\n", "Retinal", "diseases", "potentially", "requiring", "treatment", "during", "the", "following", "3", "months", "\n", "History", "of", "penetrating", "keratoplasty", ".", "\n", "Soft", "or", "hard", "contact", "lenses", "use", "during", "the", "last", "month", "from", "inclusion", "day", "\n" ]	[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]
topical and / or systemic medication or mechanical devices is a Scope, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses is a Scope, females is a Person, active sexual life is a Observation, not is a Negation, contraceptive method is a Procedure, Female is a Person, pregnant is a Condition, lactating is a Condition, Female is a Person, positive is a Value, urine pregnancy test is a Measurement, Positive drug addictions is a Condition, verbal interrogatory is a Procedure, mentally disabled is a Condition, Serious tear film dysfunction syndrome is a Condition, TBUT is a Measurement, < 5 s is a Value, Schirmer is a Measurement, < 4 mm is a Value, OSDI is a Measurement, > 30 pints is a Value, Corneal staining is a Measurement, > grade III is a Value, Oxford scale is a Qualifier, Non perforated is a Qualifier, corneal ulcer is a Condition, Perforated is a Qualifier, corneal ulcer is a Condition, Autoimmune is a Qualifier, corneal ulcer is a Condition, Ocular surface scarring diseases is a Condition, Fibro vascular proliferation lesions is a Condition, conjunctival and / or corneal surface is a Scope, pterygium is a Qualifier, Concomitant is a Temporal, chronic inflammatory diseases is a Condition, ocular structure is a Qualifier, Acute or infectious is a Scope, inflammatory disease is a Condition, Corneal disease is a Condition, potentially requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, Ocular surgical procedures is a Procedure, 3 months before the protocol inclusion is a Temporal, Treatments or procedures is a Scope, tear film dysfunction treatment is a Procedure, punctal silicone plugs is a Device, Posterior segment diseases is a Condition, requiring a treatment or threatening the visual prognosis is a Scope, Retinal diseases is a Condition, requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, History is a Observation, penetrating keratoplasty is a Procedure, Soft or hard contact lenses is a Scope, during the last month from inclusion day is a Temporal	NCT03223909_exc_task1	Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please typing these entity words according to sentence: topical and / or systemic medication or mechanical devices, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses, females, active sexual life, not, contraceptive method, Female, pregnant, lactating, Female, positive, urine pregnancy test, Positive drug addictions, verbal interrogatory, mentally disabled, Serious tear film dysfunction syndrome, TBUT, < 5 s, Schirmer, < 4 mm, OSDI, > 30 pints, Corneal staining, > grade III, Oxford scale, Non perforated, corneal ulcer, Perforated, corneal ulcer, Autoimmune, corneal ulcer, Ocular surface scarring diseases, Fibro vascular proliferation lesions, conjunctival and / or corneal surface, pterygium, Concomitant, chronic inflammatory diseases, ocular structure, Acute or infectious, inflammatory disease, Corneal disease, potentially requiring, treatment, during the following 3 months, Ocular surgical procedures, 3 months before the protocol inclusion, Treatments or procedures, tear film dysfunction treatment, punctal silicone plugs, Posterior segment diseases, requiring a treatment or threatening the visual prognosis, Retinal diseases, requiring, treatment, during the following 3 months, History, penetrating keratoplasty, Soft or hard contact lenses, during the last month from inclusion day Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Negation, Scope, Measurement, Device, Mood	[ "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Person", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "B-Negation", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Person", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "B-Person", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Qualifier", "O", "O", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Mood", "I-Mood", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Device", "I-Device", "I-Device", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Mood", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Observation", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day	[ "Subjects", "with", "topical", "and", "/", "or", "systemic", "medication", "or", "mechanical", "devices", "that", "interfere", "determinedly", "on", "the", "results", "of", "the", "study", "(", "such", "as", "topical", "immunomodulators", ",", "punctal", "plugs", ",", "corticosteroids", ",", "preservative", "artificial", "tears", ",", "contact", "lenses", ")", ".", "\n", "Subjects", "(", "females", ")", "with", "active", "sexual", "life", "that", "do", "not", "use", "a", "contraceptive", "method", ".", "\n", "Female", "subjects", "who", "are", "pregnant", "or", "lactating", "\n", "Female", "subjects", "with", "a", "positive", "urine", "pregnancy", "test", "\n", "Positive", "drug", "addictions", "*", "(", "verbal", "interrogatory", ")", "\n", "Subjects", "who", "have", "participated", "on", "any", "other", "research", "clinical", "trials", "on", "the", "last", "40", "days", "\n", "Subjects", "legal", "or", "mentally", "disabled", "to", "give", "an", "informed", "consent", "for", "participating", "on", "this", "study", "\n", "Subjects", "who", "can't", "comply", "with", "the", "appointments", "or", "with", "every", "protocol", "requirement", ".", "\n", "Serious", "tear", "film", "dysfunction", "syndrome", "TBUT", "<", "5", "s", "Schirmer", ":", "<", "4", "mm", "OSDI", ">", "30", "pints", "Corneal", "staining", ">", "grade", "III", "on", "the", "Oxford", "scale", "\n", "Non", "perforated", "corneal", "ulcer", "\n", "Perforated", "corneal", "ulcer", "\n", "Autoimmune", "corneal", "ulcer", "\n", "Ocular", "surface", "scarring", "diseases", "\n", "Ocular", "surface", "or", "annexes", "metaplastic", "lesions", "\n", "Fibro", "vascular", "proliferation", "lesions", "on", "the", "conjunctival", "and", "/", "or", "corneal", "surface", "(", "i.e", ".", ":", "pterygium", ")", "\n", "Concomitant", "chronic", "inflammatory", "diseases", "on", "any", "ocular", "structure", "\n", "Acute", "or", "infectious", "inflammatory", "disease", "\n", "Corneal", "disease", "potentially", "requiring", "a", "treatment", "during", "the", "following", "3", "months", "\n", "Use", "of", "topical", "or", "systemic", "drug", "products", "classified", "as", "forbidden", "\n", "Ocular", "surgical", "procedures", "3", "months", "before", "the", "protocol", "inclusion", "\n", "Treatments", "or", "procedures", "indicated", "on", "the", "tear", "film", "dysfunction", "treatment", ",", "as", "punctal", "silicone", "plugs", ".", "\n", "Posterior", "segment", "diseases", "requiring", "a", "treatment", "or", "threatening", "the", "visual", "prognosis", "\n", "Retinal", "diseases", "potentially", "requiring", "treatment", "during", "the", "following", "3", "months", "\n", "History", "of", "penetrating", "keratoplasty", ".", "\n", "Soft", "or", "hard", "contact", "lenses", "use", "during", "the", "last", "month", "from", "inclusion", "day", "\n" ]	[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]
topical and / or systemic medication or mechanical devices, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses, females, active sexual life, not, contraceptive method, Female, pregnant, lactating, Female, positive, urine pregnancy test, Positive drug addictions, verbal interrogatory, mentally disabled, Serious tear film dysfunction syndrome, TBUT, < 5 s, Schirmer, < 4 mm, OSDI, > 30 pints, Corneal staining, > grade III, Oxford scale, Non perforated, corneal ulcer, Perforated, corneal ulcer, Autoimmune, corneal ulcer, Ocular surface scarring diseases, Fibro vascular proliferation lesions, conjunctival and / or corneal surface, pterygium, Concomitant, chronic inflammatory diseases, ocular structure, Acute or infectious, inflammatory disease, Corneal disease, potentially requiring, treatment, during the following 3 months, Ocular surgical procedures, 3 months before the protocol inclusion, Treatments or procedures, tear film dysfunction treatment, punctal silicone plugs, Posterior segment diseases, requiring a treatment or threatening the visual prognosis, Retinal diseases, requiring, treatment, during the following 3 months, History, penetrating keratoplasty, Soft or hard contact lenses, during the last month from inclusion day	NCT03223909_exc_task2	Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Person", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "B-Negation", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Person", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "B-Person", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Qualifier", "O", "O", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Mood", "I-Mood", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Device", "I-Device", "I-Device", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "O", "B-Mood", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Observation", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day	[ "Subjects", "with", "topical", "and", "/", "or", "systemic", "medication", "or", "mechanical", "devices", "that", "interfere", "determinedly", "on", "the", "results", "of", "the", "study", "(", "such", "as", "topical", "immunomodulators", ",", "punctal", "plugs", ",", "corticosteroids", ",", "preservative", "artificial", "tears", ",", "contact", "lenses", ")", ".", "\n", "Subjects", "(", "females", ")", "with", "active", "sexual", "life", "that", "do", "not", "use", "a", "contraceptive", "method", ".", "\n", "Female", "subjects", "who", "are", "pregnant", "or", "lactating", "\n", "Female", "subjects", "with", "a", "positive", "urine", "pregnancy", "test", "\n", "Positive", "drug", "addictions", "*", "(", "verbal", "interrogatory", ")", "\n", "Subjects", "who", "have", "participated", "on", "any", "other", "research", "clinical", "trials", "on", "the", "last", "40", "days", "\n", "Subjects", "legal", "or", "mentally", "disabled", "to", "give", "an", "informed", "consent", "for", "participating", "on", "this", "study", "\n", "Subjects", "who", "can't", "comply", "with", "the", "appointments", "or", "with", "every", "protocol", "requirement", ".", "\n", "Serious", "tear", "film", "dysfunction", "syndrome", "TBUT", "<", "5", "s", "Schirmer", ":", "<", "4", "mm", "OSDI", ">", "30", "pints", "Corneal", "staining", ">", "grade", "III", "on", "the", "Oxford", "scale", "\n", "Non", "perforated", "corneal", "ulcer", "\n", "Perforated", "corneal", "ulcer", "\n", "Autoimmune", "corneal", "ulcer", "\n", "Ocular", "surface", "scarring", "diseases", "\n", "Ocular", "surface", "or", "annexes", "metaplastic", "lesions", "\n", "Fibro", "vascular", "proliferation", "lesions", "on", "the", "conjunctival", "and", "/", "or", "corneal", "surface", "(", "i.e", ".", ":", "pterygium", ")", "\n", "Concomitant", "chronic", "inflammatory", "diseases", "on", "any", "ocular", "structure", "\n", "Acute", "or", "infectious", "inflammatory", "disease", "\n", "Corneal", "disease", "potentially", "requiring", "a", "treatment", "during", "the", "following", "3", "months", "\n", "Use", "of", "topical", "or", "systemic", "drug", "products", "classified", "as", "forbidden", "\n", "Ocular", "surgical", "procedures", "3", "months", "before", "the", "protocol", "inclusion", "\n", "Treatments", "or", "procedures", "indicated", "on", "the", "tear", "film", "dysfunction", "treatment", ",", "as", "punctal", "silicone", "plugs", ".", "\n", "Posterior", "segment", "diseases", "requiring", "a", "treatment", "or", "threatening", "the", "visual", "prognosis", "\n", "Retinal", "diseases", "potentially", "requiring", "treatment", "during", "the", "following", "3", "months", "\n", "History", "of", "penetrating", "keratoplasty", ".", "\n", "Soft", "or", "hard", "contact", "lenses", "use", "during", "the", "last", "month", "from", "inclusion", "day", "\n" ]	[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]
Kalkaneus is an umlsterm, Knochenzyste is an umlsterm, Fussskeletts is an umlsterm, Belastung is an umlsterm, Gelenkabstaende is an umlsterm, Zysten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, radiologisch is an umlsterm, Standardtherapie is an umlsterm, Becken is an umlsterm, Literatur is an umlsterm, Diagnostik is an umlsterm, Behandlung is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm	DerUnfallchirurg.91020576.ger.abstr_task0	Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .	[ "Der", "Kalkaneus", "ist", "eine", "ungewoehnliche", "Lokalisation", "fuer", "eine", "einkammrige", ",", "solitaere", "Knochenzyste", ".", "Aufgrund", "der", "Besonderheiten", "des", "Fussskeletts", "wie", "hoeherer", "statischer", "Belastung", "und", "geringer", "Gelenkabstaende", "kommt", "es", "hier", "schneller", "zu", "Beschwerden", "im", "Vergleich", "zu", "anderen", "Lokalisationen", ",", "deswegen", "beanspruchen", "diese", "Zysten", "meist", "eine", "chirurgische", "Behandlung", ",", "abhaengig", "natuerlich", "auch", "von", "der", "Groesse", "des", "Befunds", ".", "Wir", "berichten", "ueber", "2", "Patienten", "aus", "den", "Jahren", "1996", "und", "1997", "mit", "solitaeren", "Fersenbeinzysten", ".", "Die", "Diagnose", "wurde", "radiologisch", "und", "histologisch", "gesichert", ".", "Die", "Standardtherapie", "in", "beiden", "Faellen", "war", "die", "Kuerretage", "und", "die", "Auffuellung", "des", "Defekts", "mit", "autologer", "Spongiosa", "vom", "Becken", ".", "Der", "Autor", "gibt", "einen", "Ueberblick", "ueber", "die", "Literatur", ",", "ueber", "Diagnostik", "und", "Behandlung", "solitaerer", "Fersenbeinzysten", ".", "Die", "Diagnose", "kann", "nicht", "allein", "aufgrund", "des", "Roentgenbefunds", "sicher", "gestellt", "werden", ",", "da", "es", "weitgespannte", "Variationsmoeglichkeiten", ",", "wie", "z", ".", "B.", "verkalkende", "Fersenbeinzysten", "gibt", ".", "Deswegen", "ist", "die", "exakte", "histologische", "Diagnose", "zwingend", "erforderlich", "." ]	[ "umlsterm" ]
Kalkaneus is an umlsterm, Knochenzyste is an umlsterm, Fussskeletts is an umlsterm, Belastung is an umlsterm, Gelenkabstaende is an umlsterm, Zysten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, radiologisch is an umlsterm, Standardtherapie is an umlsterm, Becken is an umlsterm, Literatur is an umlsterm, Diagnostik is an umlsterm, Behandlung is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm	DerUnfallchirurg.91020576.ger.abstr_task1	Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please typing these entity words according to sentence: Kalkaneus, Knochenzyste, Fussskeletts, Belastung, Gelenkabstaende, Zysten, Behandlung, Patienten, Fersenbeinzysten, Diagnose, radiologisch, Standardtherapie, Becken, Literatur, Diagnostik, Behandlung, Fersenbeinzysten, Diagnose, Fersenbeinzysten, Diagnose Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .	[ "Der", "Kalkaneus", "ist", "eine", "ungewoehnliche", "Lokalisation", "fuer", "eine", "einkammrige", ",", "solitaere", "Knochenzyste", ".", "Aufgrund", "der", "Besonderheiten", "des", "Fussskeletts", "wie", "hoeherer", "statischer", "Belastung", "und", "geringer", "Gelenkabstaende", "kommt", "es", "hier", "schneller", "zu", "Beschwerden", "im", "Vergleich", "zu", "anderen", "Lokalisationen", ",", "deswegen", "beanspruchen", "diese", "Zysten", "meist", "eine", "chirurgische", "Behandlung", ",", "abhaengig", "natuerlich", "auch", "von", "der", "Groesse", "des", "Befunds", ".", "Wir", "berichten", "ueber", "2", "Patienten", "aus", "den", "Jahren", "1996", "und", "1997", "mit", "solitaeren", "Fersenbeinzysten", ".", "Die", "Diagnose", "wurde", "radiologisch", "und", "histologisch", "gesichert", ".", "Die", "Standardtherapie", "in", "beiden", "Faellen", "war", "die", "Kuerretage", "und", "die", "Auffuellung", "des", "Defekts", "mit", "autologer", "Spongiosa", "vom", "Becken", ".", "Der", "Autor", "gibt", "einen", "Ueberblick", "ueber", "die", "Literatur", ",", "ueber", "Diagnostik", "und", "Behandlung", "solitaerer", "Fersenbeinzysten", ".", "Die", "Diagnose", "kann", "nicht", "allein", "aufgrund", "des", "Roentgenbefunds", "sicher", "gestellt", "werden", ",", "da", "es", "weitgespannte", "Variationsmoeglichkeiten", ",", "wie", "z", ".", "B.", "verkalkende", "Fersenbeinzysten", "gibt", ".", "Deswegen", "ist", "die", "exakte", "histologische", "Diagnose", "zwingend", "erforderlich", "." ]	[ "umlsterm" ]
Kalkaneus, Knochenzyste, Fussskeletts, Belastung, Gelenkabstaende, Zysten, Behandlung, Patienten, Fersenbeinzysten, Diagnose, radiologisch, Standardtherapie, Becken, Literatur, Diagnostik, Behandlung, Fersenbeinzysten, Diagnose, Fersenbeinzysten, Diagnose	DerUnfallchirurg.91020576.ger.abstr_task2	Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .	[ "Der", "Kalkaneus", "ist", "eine", "ungewoehnliche", "Lokalisation", "fuer", "eine", "einkammrige", ",", "solitaere", "Knochenzyste", ".", "Aufgrund", "der", "Besonderheiten", "des", "Fussskeletts", "wie", "hoeherer", "statischer", "Belastung", "und", "geringer", "Gelenkabstaende", "kommt", "es", "hier", "schneller", "zu", "Beschwerden", "im", "Vergleich", "zu", "anderen", "Lokalisationen", ",", "deswegen", "beanspruchen", "diese", "Zysten", "meist", "eine", "chirurgische", "Behandlung", ",", "abhaengig", "natuerlich", "auch", "von", "der", "Groesse", "des", "Befunds", ".", "Wir", "berichten", "ueber", "2", "Patienten", "aus", "den", "Jahren", "1996", "und", "1997", "mit", "solitaeren", "Fersenbeinzysten", ".", "Die", "Diagnose", "wurde", "radiologisch", "und", "histologisch", "gesichert", ".", "Die", "Standardtherapie", "in", "beiden", "Faellen", "war", "die", "Kuerretage", "und", "die", "Auffuellung", "des", "Defekts", "mit", "autologer", "Spongiosa", "vom", "Becken", ".", "Der", "Autor", "gibt", "einen", "Ueberblick", "ueber", "die", "Literatur", ",", "ueber", "Diagnostik", "und", "Behandlung", "solitaerer", "Fersenbeinzysten", ".", "Die", "Diagnose", "kann", "nicht", "allein", "aufgrund", "des", "Roentgenbefunds", "sicher", "gestellt", "werden", ",", "da", "es", "weitgespannte", "Variationsmoeglichkeiten", ",", "wie", "z", ".", "B.", "verkalkende", "Fersenbeinzysten", "gibt", ".", "Deswegen", "ist", "die", "exakte", "histologische", "Diagnose", "zwingend", "erforderlich", "." ]	[ "umlsterm" ]
CLNO2 is a compound, lipopolysaccharide is a compound, interferon - gamma is a protein, NOS2 is a protein, nitric oxide synthase is a protein, N(G)-nitro - L - arginine methyl ester is a compound	DS.d672_task0	Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]	[ "compound", "protein" ]
CLNO2 is a compound, lipopolysaccharide is a compound, interferon - gamma is a protein, NOS2 is a protein, nitric oxide synthase is a protein, N(G)-nitro - L - arginine methyl ester is a compound	DS.d672_task1	Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please typing these entity words according to sentence: CLNO2, lipopolysaccharide, interferon - gamma, NOS2, nitric oxide synthase, N(G)-nitro - L - arginine methyl ester Options: compound, protein	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]	[ "compound", "protein" ]
CLNO2, lipopolysaccharide, interferon - gamma, NOS2, nitric oxide synthase, N(G)-nitro - L - arginine methyl ester	DS.d672_task2	Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please extract entity words from the input sentence	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]	[ "compound", "protein" ]
NF - kappaB - mediated up - regulation is a cell_type, Bcl - x is a protein_molecule, Bfl-1 / A1 is a protein_molecule, CD40 survival signaling is an other_name, B lymphocytes is a cell_type	34152_task0	Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, other_name, protein_molecule	[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.	[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]	[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]
NF - kappaB - mediated up - regulation is a cell_type, Bcl - x is a protein_molecule, Bfl-1 / A1 is a protein_molecule, CD40 survival signaling is an other_name, B lymphocytes is a cell_type	34152_task1	Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please typing these entity words according to sentence: NF - kappaB - mediated up - regulation, Bcl - x, Bfl-1 / A1, CD40 survival signaling, B lymphocytes Options: cell_type, other_name, protein_molecule	[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.	[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]	[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]
NF - kappaB - mediated up - regulation, Bcl - x, Bfl-1 / A1, CD40 survival signaling, B lymphocytes	34152_task2	Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please extract entity words from the input sentence	[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.	[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]	[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]
interleukin-8 AP-1 and kappa B - like sites is a (AND DNA_domain_or_region DNA_domain_or_region), FK506-sensitive pathway is an other_name, calcium mobilization is an other_name	13487_task0	Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: (AND DNA_domain_or_region DNA_domain_or_region), other_name	[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.	[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]
interleukin-8 AP-1 and kappa B - like sites is a (AND DNA_domain_or_region DNA_domain_or_region), FK506-sensitive pathway is an other_name, calcium mobilization is an other_name	13487_task1	Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please typing these entity words according to sentence: interleukin-8 AP-1 and kappa B - like sites, FK506-sensitive pathway, calcium mobilization Options: (AND DNA_domain_or_region DNA_domain_or_region), other_name	[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.	[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]
interleukin-8 AP-1 and kappa B - like sites, FK506-sensitive pathway, calcium mobilization	13487_task2	Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please extract entity words from the input sentence	[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.	[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]	[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]
choroidal neovascularization is a Condition, age - related is a Qualifier, macula degeneration is a Condition, no is a Negation, previous is a Temporal, treatment is a Procedure, follow - up is a Observation, at least 12 months is a Temporal, baseline is a Temporal, visual acuity is a Measurement, letter score of 0 to 70 is a Value, Early Treatment Diabetic Retinopathy Study chart is a Procedure	NCT01032109_inc_task0	Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Observation, Procedure, Negation, Measurement	[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]	choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart	[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]	[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]
choroidal neovascularization is a Condition, age - related is a Qualifier, macula degeneration is a Condition, no is a Negation, previous is a Temporal, treatment is a Procedure, follow - up is a Observation, at least 12 months is a Temporal, baseline is a Temporal, visual acuity is a Measurement, letter score of 0 to 70 is a Value, Early Treatment Diabetic Retinopathy Study chart is a Procedure	NCT01032109_inc_task1	Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please typing these entity words according to sentence: choroidal neovascularization, age - related, macula degeneration, no, previous, treatment, follow - up, at least 12 months, baseline, visual acuity, letter score of 0 to 70, Early Treatment Diabetic Retinopathy Study chart Options: Temporal, Condition, Qualifier, Value, Observation, Procedure, Negation, Measurement	[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]	choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart	[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]	[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]
choroidal neovascularization, age - related, macula degeneration, no, previous, treatment, follow - up, at least 12 months, baseline, visual acuity, letter score of 0 to 70, Early Treatment Diabetic Retinopathy Study chart	NCT01032109_inc_task2	Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please extract entity words from the input sentence	[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]	choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart	[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]	[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]
Kopfschmerz is an umlsterm, Meningismus is an umlsterm, Fieber is an umlsterm, Computertomographie is an umlsterm, Subarachnoidalblutung is an umlsterm, Blutung is an umlsterm, Hydrozephalus is an umlsterm, Tumor is an umlsterm, Liquorpunktion is an umlsterm, Meningitis is an umlsterm, Meningoenzephalitis is an umlsterm, chronischen Kopfschmerzen is an umlsterm, Diagnose is an umlsterm, Charakter is an umlsterm, Kopfschmerzen is an umlsterm, Kopfschmerzen is an umlsterm	DerSchmerz.60100135.ger.abstr_task0	Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .	[ "Ein", "erstmals", "akut", "einsetzender", "heftiger", "Kopfschmerz", "insbesondere", "mit", "Meningismus", "oder", "Fieber", "bedarf", "einer", "sofortigen", "Abklaerung", "mit", "Hilfe", "von", "Computertomographie", "(", "CT", "Ausschluss", "Subarachnoidalblutung", ",", "Blutung", ",", "Hydrozephalus", ",", "Tumor", ")", ",", "und", "im", "Falle", "eines", "Normalbefundes", "einer", "Liquorpunktion", "(", "Ausschluss", "Meningitis", ",", "Meningoenzephalitis", ")", ".", "Bei", "chronisch", "rezidivierenden", "oder", "chronischen", "Kopfschmerzen", "ohne", "neurologische", "Ausfaelle", "und", "ohne", "psychopathologische", "Auffaelligkeiten", "sind", "technische", "Zusatzuntersuchungen", "entbehrlich", ".", "Hier", "stuetzt", "sich", "die", "Diagnose", "auf", "Anamnese", "und", "sorgfaeltige", "klinische", "Untersuchung", ".", "Ein", "CT", "ist", "nur", "dann", "erforderlich", ",", "wenn", "sich", "der", "Charakter", "der", "Kopfschmerzen", "eindeutig", "aendert", "oder", "wenn", "die", "Kopfschmerzen", "mit", "persistierenden", "neurologi-", "schen", "Herdsymptomen", "einher-", "gehen", "." ]	[ "umlsterm" ]
Kopfschmerz is an umlsterm, Meningismus is an umlsterm, Fieber is an umlsterm, Computertomographie is an umlsterm, Subarachnoidalblutung is an umlsterm, Blutung is an umlsterm, Hydrozephalus is an umlsterm, Tumor is an umlsterm, Liquorpunktion is an umlsterm, Meningitis is an umlsterm, Meningoenzephalitis is an umlsterm, chronischen Kopfschmerzen is an umlsterm, Diagnose is an umlsterm, Charakter is an umlsterm, Kopfschmerzen is an umlsterm, Kopfschmerzen is an umlsterm	DerSchmerz.60100135.ger.abstr_task1	Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please typing these entity words according to sentence: Kopfschmerz, Meningismus, Fieber, Computertomographie, Subarachnoidalblutung, Blutung, Hydrozephalus, Tumor, Liquorpunktion, Meningitis, Meningoenzephalitis, chronischen Kopfschmerzen, Diagnose, Charakter, Kopfschmerzen, Kopfschmerzen Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .	[ "Ein", "erstmals", "akut", "einsetzender", "heftiger", "Kopfschmerz", "insbesondere", "mit", "Meningismus", "oder", "Fieber", "bedarf", "einer", "sofortigen", "Abklaerung", "mit", "Hilfe", "von", "Computertomographie", "(", "CT", "Ausschluss", "Subarachnoidalblutung", ",", "Blutung", ",", "Hydrozephalus", ",", "Tumor", ")", ",", "und", "im", "Falle", "eines", "Normalbefundes", "einer", "Liquorpunktion", "(", "Ausschluss", "Meningitis", ",", "Meningoenzephalitis", ")", ".", "Bei", "chronisch", "rezidivierenden", "oder", "chronischen", "Kopfschmerzen", "ohne", "neurologische", "Ausfaelle", "und", "ohne", "psychopathologische", "Auffaelligkeiten", "sind", "technische", "Zusatzuntersuchungen", "entbehrlich", ".", "Hier", "stuetzt", "sich", "die", "Diagnose", "auf", "Anamnese", "und", "sorgfaeltige", "klinische", "Untersuchung", ".", "Ein", "CT", "ist", "nur", "dann", "erforderlich", ",", "wenn", "sich", "der", "Charakter", "der", "Kopfschmerzen", "eindeutig", "aendert", "oder", "wenn", "die", "Kopfschmerzen", "mit", "persistierenden", "neurologi-", "schen", "Herdsymptomen", "einher-", "gehen", "." ]	[ "umlsterm" ]
Kopfschmerz, Meningismus, Fieber, Computertomographie, Subarachnoidalblutung, Blutung, Hydrozephalus, Tumor, Liquorpunktion, Meningitis, Meningoenzephalitis, chronischen Kopfschmerzen, Diagnose, Charakter, Kopfschmerzen, Kopfschmerzen	DerSchmerz.60100135.ger.abstr_task2	Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .	[ "Ein", "erstmals", "akut", "einsetzender", "heftiger", "Kopfschmerz", "insbesondere", "mit", "Meningismus", "oder", "Fieber", "bedarf", "einer", "sofortigen", "Abklaerung", "mit", "Hilfe", "von", "Computertomographie", "(", "CT", "Ausschluss", "Subarachnoidalblutung", ",", "Blutung", ",", "Hydrozephalus", ",", "Tumor", ")", ",", "und", "im", "Falle", "eines", "Normalbefundes", "einer", "Liquorpunktion", "(", "Ausschluss", "Meningitis", ",", "Meningoenzephalitis", ")", ".", "Bei", "chronisch", "rezidivierenden", "oder", "chronischen", "Kopfschmerzen", "ohne", "neurologische", "Ausfaelle", "und", "ohne", "psychopathologische", "Auffaelligkeiten", "sind", "technische", "Zusatzuntersuchungen", "entbehrlich", ".", "Hier", "stuetzt", "sich", "die", "Diagnose", "auf", "Anamnese", "und", "sorgfaeltige", "klinische", "Untersuchung", ".", "Ein", "CT", "ist", "nur", "dann", "erforderlich", ",", "wenn", "sich", "der", "Charakter", "der", "Kopfschmerzen", "eindeutig", "aendert", "oder", "wenn", "die", "Kopfschmerzen", "mit", "persistierenden", "neurologi-", "schen", "Herdsymptomen", "einher-", "gehen", "." ]	[ "umlsterm" ]
tamoxifen is a Intervention_Pharmacological, reducing the incidence of invasive breast cancer is a Outcome_Physical, reducing breast cancer mortality is a Outcome_Mortality, reducing deaths from cardiovascular disease is a Outcome_Mortality, reducing bone fractures is a Outcome_Physical, side effects , is a Outcome_Adverse-effects, toxicity is a Outcome_Mortality, quality of life is a Outcome_Other	84175_task0	Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "B-Outcome_Mortality", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O" ]	National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .	[ "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", "'", "s", "Breast", "Cancer", "Prevention", "Trial", ".", "The", "Breast", "Cancer", "Prevention", "Trial", "is", "the", "largest", "breast", "cancer", "prevention", "study", "ever", "undertaken", ".", "Administered", "by", "the", "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", ",", "it", "is", "the", "first", "trial", "seeking", "to", "demonstrate", "whether", "a", "drug", ",", "tamoxifen", ",", "can", "prevent", "breast", "cancer", "in", "high", "-", "risk", "women", ".", "The", "objectives", "of", "this", "trial", "are", "to", "determine", "whether", "tamoxifen", "is", "effective", "in", "1", ")", "reducing", "the", "incidence", "of", "invasive", "breast", "cancer", ",", "2", ")", "reducing", "breast", "cancer", "mortality", ",", "3", ")", "reducing", "deaths", "from", "cardiovascular", "disease", ",", "and", "4", ")", "reducing", "bone", "fractures", ".", "In", "addition", ",", "the", "study", "will", "evaluate", "side", "effects", ",", "toxicity", ",", "and", "the", "quality", "of", "life", "of", "all", "study", "participants", "." ]	[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]
tamoxifen is a Intervention_Pharmacological, reducing the incidence of invasive breast cancer is a Outcome_Physical, reducing breast cancer mortality is a Outcome_Mortality, reducing deaths from cardiovascular disease is a Outcome_Mortality, reducing bone fractures is a Outcome_Physical, side effects , is a Outcome_Adverse-effects, toxicity is a Outcome_Mortality, quality of life is a Outcome_Other	84175_task1	Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please typing these entity words according to sentence: tamoxifen, reducing the incidence of invasive breast cancer, reducing breast cancer mortality, reducing deaths from cardiovascular disease, reducing bone fractures, side effects ,, toxicity, quality of life Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "B-Outcome_Mortality", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O" ]	National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .	[ "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", "'", "s", "Breast", "Cancer", "Prevention", "Trial", ".", "The", "Breast", "Cancer", "Prevention", "Trial", "is", "the", "largest", "breast", "cancer", "prevention", "study", "ever", "undertaken", ".", "Administered", "by", "the", "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", ",", "it", "is", "the", "first", "trial", "seeking", "to", "demonstrate", "whether", "a", "drug", ",", "tamoxifen", ",", "can", "prevent", "breast", "cancer", "in", "high", "-", "risk", "women", ".", "The", "objectives", "of", "this", "trial", "are", "to", "determine", "whether", "tamoxifen", "is", "effective", "in", "1", ")", "reducing", "the", "incidence", "of", "invasive", "breast", "cancer", ",", "2", ")", "reducing", "breast", "cancer", "mortality", ",", "3", ")", "reducing", "deaths", "from", "cardiovascular", "disease", ",", "and", "4", ")", "reducing", "bone", "fractures", ".", "In", "addition", ",", "the", "study", "will", "evaluate", "side", "effects", ",", "toxicity", ",", "and", "the", "quality", "of", "life", "of", "all", "study", "participants", "." ]	[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]
tamoxifen, reducing the incidence of invasive breast cancer, reducing breast cancer mortality, reducing deaths from cardiovascular disease, reducing bone fractures, side effects ,, toxicity, quality of life	84175_task2	Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "B-Outcome_Mortality", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O" ]	National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .	[ "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", "'", "s", "Breast", "Cancer", "Prevention", "Trial", ".", "The", "Breast", "Cancer", "Prevention", "Trial", "is", "the", "largest", "breast", "cancer", "prevention", "study", "ever", "undertaken", ".", "Administered", "by", "the", "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", ",", "it", "is", "the", "first", "trial", "seeking", "to", "demonstrate", "whether", "a", "drug", ",", "tamoxifen", ",", "can", "prevent", "breast", "cancer", "in", "high", "-", "risk", "women", ".", "The", "objectives", "of", "this", "trial", "are", "to", "determine", "whether", "tamoxifen", "is", "effective", "in", "1", ")", "reducing", "the", "incidence", "of", "invasive", "breast", "cancer", ",", "2", ")", "reducing", "breast", "cancer", "mortality", ",", "3", ")", "reducing", "deaths", "from", "cardiovascular", "disease", ",", "and", "4", ")", "reducing", "bone", "fractures", ".", "In", "addition", ",", "the", "study", "will", "evaluate", "side", "effects", ",", "toxicity", ",", "and", "the", "quality", "of", "life", "of", "all", "study", "participants", "." ]	[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]
development is an umlsterm, carcinoma is an umlsterm, pleomorphic adenoma is an umlsterm, minor salivary glands is an umlsterm, buccal mucosa is an umlsterm, female is an umlsterm, Tumor is an umlsterm, neoplasm is an umlsterm, pleomorphic adenoma is an umlsterm, minor is an umlsterm, carcinoma is an umlsterm, Recurrences is an umlsterm, tumor is an umlsterm, Histopathological is an umlsterm, tissue is an umlsterm, carcinoma is an umlsterm, minor salivary glands is an umlsterm, pleomorphic adenoma is an umlsterm, therapy is an umlsterm, diagnosis is an umlsterm, histopathology is an umlsterm, literature is an umlsterm	HNO.80460066.eng.abstr_task0	Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .	[ "We", "report", "the", "rare", "development", "of", "a", "myoepithelial", "carcinoma", "in", "a", "pleomorphic", "adenoma", "involving", "the", "minor", "salivary", "glands", "in", "the", "buccal", "mucosa", "of", "a", "78-year", "-", "old", "female", ".", "Tumor", "presented", "as", "a", "small", "asymptomatic", "left", "buccal", "mass", ".", "The", "initial", "dominant", "component", "of", "the", "neoplasm", "was", "a", "pleomorphic", "adenoma", ",", "while", "the", "minor", "component", "was", "a", "myoepithelial", "carcinoma", ".", "Recurrences", "of", "tumor", "after", "2", "and", "then", "5", "years", "were", "excised", ".", "Histopathological", "examination", "of", "the", "last", "tissue", "removed", "showed", "a", "pure", "myoepithelial", "carcinoma", "of", "the", "minor", "salivary", "glands", "without", "evidence", "for", "a", "pleomorphic", "adenoma", ".", "The", "clinical", "features", ",", "therapy", ",", "diagnosis", ",", "histopathology", "and", "literature", "are", "reviewed", "." ]	[ "umlsterm" ]
development is an umlsterm, carcinoma is an umlsterm, pleomorphic adenoma is an umlsterm, minor salivary glands is an umlsterm, buccal mucosa is an umlsterm, female is an umlsterm, Tumor is an umlsterm, neoplasm is an umlsterm, pleomorphic adenoma is an umlsterm, minor is an umlsterm, carcinoma is an umlsterm, Recurrences is an umlsterm, tumor is an umlsterm, Histopathological is an umlsterm, tissue is an umlsterm, carcinoma is an umlsterm, minor salivary glands is an umlsterm, pleomorphic adenoma is an umlsterm, therapy is an umlsterm, diagnosis is an umlsterm, histopathology is an umlsterm, literature is an umlsterm	HNO.80460066.eng.abstr_task1	Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please typing these entity words according to sentence: development, carcinoma, pleomorphic adenoma, minor salivary glands, buccal mucosa, female, Tumor, neoplasm, pleomorphic adenoma, minor, carcinoma, Recurrences, tumor, Histopathological, tissue, carcinoma, minor salivary glands, pleomorphic adenoma, therapy, diagnosis, histopathology, literature Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .	[ "We", "report", "the", "rare", "development", "of", "a", "myoepithelial", "carcinoma", "in", "a", "pleomorphic", "adenoma", "involving", "the", "minor", "salivary", "glands", "in", "the", "buccal", "mucosa", "of", "a", "78-year", "-", "old", "female", ".", "Tumor", "presented", "as", "a", "small", "asymptomatic", "left", "buccal", "mass", ".", "The", "initial", "dominant", "component", "of", "the", "neoplasm", "was", "a", "pleomorphic", "adenoma", ",", "while", "the", "minor", "component", "was", "a", "myoepithelial", "carcinoma", ".", "Recurrences", "of", "tumor", "after", "2", "and", "then", "5", "years", "were", "excised", ".", "Histopathological", "examination", "of", "the", "last", "tissue", "removed", "showed", "a", "pure", "myoepithelial", "carcinoma", "of", "the", "minor", "salivary", "glands", "without", "evidence", "for", "a", "pleomorphic", "adenoma", ".", "The", "clinical", "features", ",", "therapy", ",", "diagnosis", ",", "histopathology", "and", "literature", "are", "reviewed", "." ]	[ "umlsterm" ]
development, carcinoma, pleomorphic adenoma, minor salivary glands, buccal mucosa, female, Tumor, neoplasm, pleomorphic adenoma, minor, carcinoma, Recurrences, tumor, Histopathological, tissue, carcinoma, minor salivary glands, pleomorphic adenoma, therapy, diagnosis, histopathology, literature	HNO.80460066.eng.abstr_task2	Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .	[ "We", "report", "the", "rare", "development", "of", "a", "myoepithelial", "carcinoma", "in", "a", "pleomorphic", "adenoma", "involving", "the", "minor", "salivary", "glands", "in", "the", "buccal", "mucosa", "of", "a", "78-year", "-", "old", "female", ".", "Tumor", "presented", "as", "a", "small", "asymptomatic", "left", "buccal", "mass", ".", "The", "initial", "dominant", "component", "of", "the", "neoplasm", "was", "a", "pleomorphic", "adenoma", ",", "while", "the", "minor", "component", "was", "a", "myoepithelial", "carcinoma", ".", "Recurrences", "of", "tumor", "after", "2", "and", "then", "5", "years", "were", "excised", ".", "Histopathological", "examination", "of", "the", "last", "tissue", "removed", "showed", "a", "pure", "myoepithelial", "carcinoma", "of", "the", "minor", "salivary", "glands", "without", "evidence", "for", "a", "pleomorphic", "adenoma", ".", "The", "clinical", "features", ",", "therapy", ",", "diagnosis", ",", "histopathology", "and", "literature", "are", "reviewed", "." ]	[ "umlsterm" ]
female is an umlsterm, patient is an umlsterm, melena is an umlsterm, cecum is an umlsterm, biopsies is an umlsterm, histiocytes is an umlsterm, diagnosis is an umlsterm, malakoplakia is an umlsterm, colon is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, melena is an umlsterm, period is an umlsterm, Malakoplakia is an umlsterm, inflammation is an umlsterm, colon is an umlsterm, diseases is an umlsterm, disorders is an umlsterm, defect is an umlsterm, syndromes is an umlsterm, heroin abuse is an umlsterm, alcohol abuse is an umlsterm, disease is an umlsterm	DerPathologe.90200351.eng.abstr_task0	Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .	[ "We", "report", "on", "a", "62-year", "-", "old", "female", "patient", "with", "melena", "in", "which", "polypoid", "lesions", "of", "the", "cecum", "were", "discovered", "endoscopically", ".", "Histological", "examination", "of", "mucosal", "biopsies", "revealed", "an", "inflammatory", "process", "with", "lots", "of", "histiocytes", "and", "so", "-", "called", "Michaelis", "-", "Gutmann", "bodies", ",", "leading", "to", "the", "diagnosis", "of", "a", "malakoplakia", "of", "the", "colon", ".", "No", "other", "organs", "were", "found", "affected", ".", "In", "the", "course", "of", "an", "antibiotic", "therapy", ",", "there", "was", "no", "melena", "detectable", "over", "a", "period", "of", "six", "months", ".", "Malakoplakia", ",", "an", "inflammation", "usually", "affecting", "the", "urogenital", "tract", ",", "is", "rarely", "found", "in", "the", "colon", ",", "with", "only", "35", "cases", "published", "until", "now", ".", "It", "is", "frequently", "associated", "with", "other", "diseases", "like", "neoplastic", "or", "inflammatory", "disorders", ",", "immune", "defect", "syndromes", "or", "heroin", "abuse", ".", "This", "spectrum", "is", "expanded", "by", "our", "report", "in", "which", "a", "long", "-", "standing", "alcohol", "abuse", "was", "found", "as", "an", "attendant", "disease", "." ]	[ "umlsterm" ]
female is an umlsterm, patient is an umlsterm, melena is an umlsterm, cecum is an umlsterm, biopsies is an umlsterm, histiocytes is an umlsterm, diagnosis is an umlsterm, malakoplakia is an umlsterm, colon is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, melena is an umlsterm, period is an umlsterm, Malakoplakia is an umlsterm, inflammation is an umlsterm, colon is an umlsterm, diseases is an umlsterm, disorders is an umlsterm, defect is an umlsterm, syndromes is an umlsterm, heroin abuse is an umlsterm, alcohol abuse is an umlsterm, disease is an umlsterm	DerPathologe.90200351.eng.abstr_task1	Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please typing these entity words according to sentence: female, patient, melena, cecum, biopsies, histiocytes, diagnosis, malakoplakia, colon, antibiotic, therapy, melena, period, Malakoplakia, inflammation, colon, diseases, disorders, defect, syndromes, heroin abuse, alcohol abuse, disease Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .	[ "We", "report", "on", "a", "62-year", "-", "old", "female", "patient", "with", "melena", "in", "which", "polypoid", "lesions", "of", "the", "cecum", "were", "discovered", "endoscopically", ".", "Histological", "examination", "of", "mucosal", "biopsies", "revealed", "an", "inflammatory", "process", "with", "lots", "of", "histiocytes", "and", "so", "-", "called", "Michaelis", "-", "Gutmann", "bodies", ",", "leading", "to", "the", "diagnosis", "of", "a", "malakoplakia", "of", "the", "colon", ".", "No", "other", "organs", "were", "found", "affected", ".", "In", "the", "course", "of", "an", "antibiotic", "therapy", ",", "there", "was", "no", "melena", "detectable", "over", "a", "period", "of", "six", "months", ".", "Malakoplakia", ",", "an", "inflammation", "usually", "affecting", "the", "urogenital", "tract", ",", "is", "rarely", "found", "in", "the", "colon", ",", "with", "only", "35", "cases", "published", "until", "now", ".", "It", "is", "frequently", "associated", "with", "other", "diseases", "like", "neoplastic", "or", "inflammatory", "disorders", ",", "immune", "defect", "syndromes", "or", "heroin", "abuse", ".", "This", "spectrum", "is", "expanded", "by", "our", "report", "in", "which", "a", "long", "-", "standing", "alcohol", "abuse", "was", "found", "as", "an", "attendant", "disease", "." ]	[ "umlsterm" ]
female, patient, melena, cecum, biopsies, histiocytes, diagnosis, malakoplakia, colon, antibiotic, therapy, melena, period, Malakoplakia, inflammation, colon, diseases, disorders, defect, syndromes, heroin abuse, alcohol abuse, disease	DerPathologe.90200351.eng.abstr_task2	Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .	[ "We", "report", "on", "a", "62-year", "-", "old", "female", "patient", "with", "melena", "in", "which", "polypoid", "lesions", "of", "the", "cecum", "were", "discovered", "endoscopically", ".", "Histological", "examination", "of", "mucosal", "biopsies", "revealed", "an", "inflammatory", "process", "with", "lots", "of", "histiocytes", "and", "so", "-", "called", "Michaelis", "-", "Gutmann", "bodies", ",", "leading", "to", "the", "diagnosis", "of", "a", "malakoplakia", "of", "the", "colon", ".", "No", "other", "organs", "were", "found", "affected", ".", "In", "the", "course", "of", "an", "antibiotic", "therapy", ",", "there", "was", "no", "melena", "detectable", "over", "a", "period", "of", "six", "months", ".", "Malakoplakia", ",", "an", "inflammation", "usually", "affecting", "the", "urogenital", "tract", ",", "is", "rarely", "found", "in", "the", "colon", ",", "with", "only", "35", "cases", "published", "until", "now", ".", "It", "is", "frequently", "associated", "with", "other", "diseases", "like", "neoplastic", "or", "inflammatory", "disorders", ",", "immune", "defect", "syndromes", "or", "heroin", "abuse", ".", "This", "spectrum", "is", "expanded", "by", "our", "report", "in", "which", "a", "long", "-", "standing", "alcohol", "abuse", "was", "found", "as", "an", "attendant", "disease", "." ]	[ "umlsterm" ]
BAG4 is a protein, Hsc70 is a protein, BAG1 is a protein	1.0alpha7.train.580_task0	Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).	[ " ", "Hence", ",", "it", "can", "be", "predicted", "that", " ", "BAG4", "binds", " ", "Hsc70", "in", "a", "manner", "analogous", "to", " ", "BAG1", "(", "3", ",", " ", "15", ")", ".", " " ]	[ "protein" ]
BAG4 is a protein, Hsc70 is a protein, BAG1 is a protein	1.0alpha7.train.580_task1	Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please typing these entity words according to sentence: BAG4, Hsc70, BAG1 Options: protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).	[ " ", "Hence", ",", "it", "can", "be", "predicted", "that", " ", "BAG4", "binds", " ", "Hsc70", "in", "a", "manner", "analogous", "to", " ", "BAG1", "(", "3", ",", " ", "15", ")", ".", " " ]	[ "protein" ]
BAG4, Hsc70, BAG1	1.0alpha7.train.580_task2	Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).	[ " ", "Hence", ",", "it", "can", "be", "predicted", "that", " ", "BAG4", "binds", " ", "Hsc70", "in", "a", "manner", "analogous", "to", " ", "BAG1", "(", "3", ",", " ", "15", ")", ".", " " ]	[ "protein" ]
healing properties is a Outcome_Physical, superficial wounds . is a Participant_Condition, Ten is a Participant_Sample-size, polyurethane is a Intervention_Pharmacological, hydrocolloid is a Intervention_Pharmacological, hydrogel is a Intervention_Pharmacological, two standard plasters is a Intervention_Physical, Evaluation of wound healing is a Outcome_Physical, Visible re - epithelialisation is a Outcome_Physical, wound area had closed is a Outcome_Physical, cosmetic outcomes is a Outcome_Physical, Histological examination of biopsies is a Outcome_Physical, dermis remained intact is a Outcome_Physical, performance of plasters is a Outcome_Physical, healing outcomes is a Outcome_Physical, re - epithelialisation and overall cosmetic outcomes is a Outcome_Physical	39376_task0	Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .	[ "Using", "a", "novel", "wound", "model", "to", "investigate", "the", "healing", "properties", "of", "products", "for", "superficial", "wounds", ".", "OBJECTIVE", "To", "establish", "a", "new", "wound", "model", "that", "can", "induce", "uniform", "abrasions", "and", "use", "it", "to", "assess", "the", "healing", "properties", "of", "a", "range", "of", "products", "commonly", "applied", "to", "these", "wounds", ".", "METHOD", "Ten", "healthy", "volunteers", "were", "enrolled", "into", "an", "open", "-", "label", ",", "randomised", ",", "intra", "-", "individual", "comparison", "pilot", "study", ".", "Five", "standardised", ",", "superficial", "abrasions", "were", "induced", "on", "their", "forearms", "by", "repeatedly", "scrubbing", "the", "skin", "with", "a", "surgical", "brush", "until", "the", "first", "signs", "of", "uniform", "glistening", "and", "punctuate", "bleeding", "were", "observed", ".", "Three", "products", "that", "promote", "a", "moist", "wound", "environment", "(", "polyurethane", ",", "hydrocolloid", ",", "hydrogel", ")", "and", "two", "standard", "plasters", "were", "randomly", "allocated", "to", "the", "test", "areas", ".", "RESULTS", "Evaluation", "of", "wound", "healing", "on", "days", "2", ",", "5", ",", "8", "and", "14", "+", "/-", "1", "showed", "best", "results", "for", "the", "polyurethane", "and", "hydrocolloid", "plasters", ".", "Visible", "re", "-", "epithelialisation", "was", "recorded", "on", "days", "5", "and", "8", ".", "More", "than", "50", "%", "of", "the", "wound", "area", "had", "closed", ".", "Video", "microscope", "images", "support", "these", "findings", ".", "The", "investigator", "and", "volunteers", "assessed", "cosmetic", "outcomes", "on", "day", "31", "+", "/-", "2", ".", "Best", "results", "were", "obtained", "for", "the", "polyurethane", "and", "hydrocolloid", "products", ",", "which", "had", "high", "mean", "scores", "close", "to", "the", "maximum", "of", "10", ".", "Histological", "examination", "of", "biopsies", "taken", "from", "the", "abrasions", "of", "two", "volunteers", "showed", "the", "dermis", "remained", "intact", ",", "making", "the", "model", "highly", "suitable", "for", "the", "study", "of", "superficial", "wounds", ".", "CONCLUSION", "Uniform", "and", "identical", "standardised", "wounds", "created", "using", "an", "abrasive", "brush", "technique", "can", "be", "used", "to", "reliably", "detect", "differences", "in", "the", "performance", "of", "plasters", "intended", "for", "superficial", "wounds", ".", "In", "general", ",", "products", "that", "promote", "a", "moist", "wound", "environment", "produced", "better", "results", "than", "those", "that", "promote", "a", "dry", "wound", "environment", ",", "with", "an", "earlier", "onset", "of", "healing", "and", "better", "healing", "outcomes", ".", "Superficial", "cutaneous", "wounds", "treated", "with", "polyurethane", "or", "hydrocolloid", "products", "demonstrated", "superior", "rates", "of", "re", "-", "epithelialisation", "and", "overall", "cosmetic", "outcomes", ".", "DECLARATION", "OF", "INTEREST", "This", "study", "was", "funded", "by", "Beiersdorf", "AG", ".", "Neither", "author", "has", "any", "interest", "in", "the", "sponsor", "'", "s", "commercial", "activities", "." ]	[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
healing properties is a Outcome_Physical, superficial wounds . is a Participant_Condition, Ten is a Participant_Sample-size, polyurethane is a Intervention_Pharmacological, hydrocolloid is a Intervention_Pharmacological, hydrogel is a Intervention_Pharmacological, two standard plasters is a Intervention_Physical, Evaluation of wound healing is a Outcome_Physical, Visible re - epithelialisation is a Outcome_Physical, wound area had closed is a Outcome_Physical, cosmetic outcomes is a Outcome_Physical, Histological examination of biopsies is a Outcome_Physical, dermis remained intact is a Outcome_Physical, performance of plasters is a Outcome_Physical, healing outcomes is a Outcome_Physical, re - epithelialisation and overall cosmetic outcomes is a Outcome_Physical	39376_task1	Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please typing these entity words according to sentence: healing properties, superficial wounds ., Ten, polyurethane, hydrocolloid, hydrogel, two standard plasters, Evaluation of wound healing, Visible re - epithelialisation, wound area had closed, cosmetic outcomes, Histological examination of biopsies, dermis remained intact, performance of plasters, healing outcomes, re - epithelialisation and overall cosmetic outcomes Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .	[ "Using", "a", "novel", "wound", "model", "to", "investigate", "the", "healing", "properties", "of", "products", "for", "superficial", "wounds", ".", "OBJECTIVE", "To", "establish", "a", "new", "wound", "model", "that", "can", "induce", "uniform", "abrasions", "and", "use", "it", "to", "assess", "the", "healing", "properties", "of", "a", "range", "of", "products", "commonly", "applied", "to", "these", "wounds", ".", "METHOD", "Ten", "healthy", "volunteers", "were", "enrolled", "into", "an", "open", "-", "label", ",", "randomised", ",", "intra", "-", "individual", "comparison", "pilot", "study", ".", "Five", "standardised", ",", "superficial", "abrasions", "were", "induced", "on", "their", "forearms", "by", "repeatedly", "scrubbing", "the", "skin", "with", "a", "surgical", "brush", "until", "the", "first", "signs", "of", "uniform", "glistening", "and", "punctuate", "bleeding", "were", "observed", ".", "Three", "products", "that", "promote", "a", "moist", "wound", "environment", "(", "polyurethane", ",", "hydrocolloid", ",", "hydrogel", ")", "and", "two", "standard", "plasters", "were", "randomly", "allocated", "to", "the", "test", "areas", ".", "RESULTS", "Evaluation", "of", "wound", "healing", "on", "days", "2", ",", "5", ",", "8", "and", "14", "+", "/-", "1", "showed", "best", "results", "for", "the", "polyurethane", "and", "hydrocolloid", "plasters", ".", "Visible", "re", "-", "epithelialisation", "was", "recorded", "on", "days", "5", "and", "8", ".", "More", "than", "50", "%", "of", "the", "wound", "area", "had", "closed", ".", "Video", "microscope", "images", "support", "these", "findings", ".", "The", "investigator", "and", "volunteers", "assessed", "cosmetic", "outcomes", "on", "day", "31", "+", "/-", "2", ".", "Best", "results", "were", "obtained", "for", "the", "polyurethane", "and", "hydrocolloid", "products", ",", "which", "had", "high", "mean", "scores", "close", "to", "the", "maximum", "of", "10", ".", "Histological", "examination", "of", "biopsies", "taken", "from", "the", "abrasions", "of", "two", "volunteers", "showed", "the", "dermis", "remained", "intact", ",", "making", "the", "model", "highly", "suitable", "for", "the", "study", "of", "superficial", "wounds", ".", "CONCLUSION", "Uniform", "and", "identical", "standardised", "wounds", "created", "using", "an", "abrasive", "brush", "technique", "can", "be", "used", "to", "reliably", "detect", "differences", "in", "the", "performance", "of", "plasters", "intended", "for", "superficial", "wounds", ".", "In", "general", ",", "products", "that", "promote", "a", "moist", "wound", "environment", "produced", "better", "results", "than", "those", "that", "promote", "a", "dry", "wound", "environment", ",", "with", "an", "earlier", "onset", "of", "healing", "and", "better", "healing", "outcomes", ".", "Superficial", "cutaneous", "wounds", "treated", "with", "polyurethane", "or", "hydrocolloid", "products", "demonstrated", "superior", "rates", "of", "re", "-", "epithelialisation", "and", "overall", "cosmetic", "outcomes", ".", "DECLARATION", "OF", "INTEREST", "This", "study", "was", "funded", "by", "Beiersdorf", "AG", ".", "Neither", "author", "has", "any", "interest", "in", "the", "sponsor", "'", "s", "commercial", "activities", "." ]	[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
healing properties, superficial wounds ., Ten, polyurethane, hydrocolloid, hydrogel, two standard plasters, Evaluation of wound healing, Visible re - epithelialisation, wound area had closed, cosmetic outcomes, Histological examination of biopsies, dermis remained intact, performance of plasters, healing outcomes, re - epithelialisation and overall cosmetic outcomes	39376_task2	Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .	[ "Using", "a", "novel", "wound", "model", "to", "investigate", "the", "healing", "properties", "of", "products", "for", "superficial", "wounds", ".", "OBJECTIVE", "To", "establish", "a", "new", "wound", "model", "that", "can", "induce", "uniform", "abrasions", "and", "use", "it", "to", "assess", "the", "healing", "properties", "of", "a", "range", "of", "products", "commonly", "applied", "to", "these", "wounds", ".", "METHOD", "Ten", "healthy", "volunteers", "were", "enrolled", "into", "an", "open", "-", "label", ",", "randomised", ",", "intra", "-", "individual", "comparison", "pilot", "study", ".", "Five", "standardised", ",", "superficial", "abrasions", "were", "induced", "on", "their", "forearms", "by", "repeatedly", "scrubbing", "the", "skin", "with", "a", "surgical", "brush", "until", "the", "first", "signs", "of", "uniform", "glistening", "and", "punctuate", "bleeding", "were", "observed", ".", "Three", "products", "that", "promote", "a", "moist", "wound", "environment", "(", "polyurethane", ",", "hydrocolloid", ",", "hydrogel", ")", "and", "two", "standard", "plasters", "were", "randomly", "allocated", "to", "the", "test", "areas", ".", "RESULTS", "Evaluation", "of", "wound", "healing", "on", "days", "2", ",", "5", ",", "8", "and", "14", "+", "/-", "1", "showed", "best", "results", "for", "the", "polyurethane", "and", "hydrocolloid", "plasters", ".", "Visible", "re", "-", "epithelialisation", "was", "recorded", "on", "days", "5", "and", "8", ".", "More", "than", "50", "%", "of", "the", "wound", "area", "had", "closed", ".", "Video", "microscope", "images", "support", "these", "findings", ".", "The", "investigator", "and", "volunteers", "assessed", "cosmetic", "outcomes", "on", "day", "31", "+", "/-", "2", ".", "Best", "results", "were", "obtained", "for", "the", "polyurethane", "and", "hydrocolloid", "products", ",", "which", "had", "high", "mean", "scores", "close", "to", "the", "maximum", "of", "10", ".", "Histological", "examination", "of", "biopsies", "taken", "from", "the", "abrasions", "of", "two", "volunteers", "showed", "the", "dermis", "remained", "intact", ",", "making", "the", "model", "highly", "suitable", "for", "the", "study", "of", "superficial", "wounds", ".", "CONCLUSION", "Uniform", "and", "identical", "standardised", "wounds", "created", "using", "an", "abrasive", "brush", "technique", "can", "be", "used", "to", "reliably", "detect", "differences", "in", "the", "performance", "of", "plasters", "intended", "for", "superficial", "wounds", ".", "In", "general", ",", "products", "that", "promote", "a", "moist", "wound", "environment", "produced", "better", "results", "than", "those", "that", "promote", "a", "dry", "wound", "environment", ",", "with", "an", "earlier", "onset", "of", "healing", "and", "better", "healing", "outcomes", ".", "Superficial", "cutaneous", "wounds", "treated", "with", "polyurethane", "or", "hydrocolloid", "products", "demonstrated", "superior", "rates", "of", "re", "-", "epithelialisation", "and", "overall", "cosmetic", "outcomes", ".", "DECLARATION", "OF", "INTEREST", "This", "study", "was", "funded", "by", "Beiersdorf", "AG", ".", "Neither", "author", "has", "any", "interest", "in", "the", "sponsor", "'", "s", "commercial", "activities", "." ]	[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]
TRP channel is a GENE-N	23415228_task0	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TRP channel is a GENE-N	23415228_task1	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please typing these entity words according to sentence: TRP channel Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TRP channel	23415228_task2	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
COL5A1 is a Gene, COL5A1 is a Gene, COL5A2 is a Gene, COL5A1 is a Gene, IVS4 - 2A-->G is a SNP, COL5A1 is a Gene	305_task0	Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.	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COL5A1 is a Gene, COL5A1 is a Gene, COL5A2 is a Gene, COL5A1 is a Gene, IVS4 - 2A-->G is a SNP, COL5A1 is a Gene	305_task1	Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please typing these entity words according to sentence: COL5A1, COL5A1, COL5A2, COL5A1, IVS4 - 2A-->G, COL5A1 Options: Gene, SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.	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COL5A1, COL5A1, COL5A2, COL5A1, IVS4 - 2A-->G, COL5A1	305_task2	Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.	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ulna is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm	Trauma+Berufskrankheit.80010040.eng.abstr_task0	Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The significance of the styloid process of the ulna in the treatment of distal radius fractures .	[ "The", "significance", "of", "the", "styloid", "process", "of", "the", "ulna", "in", "the", "treatment", "of", "distal", "radius", "fractures", "." ]	[ "umlsterm" ]
ulna is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm	Trauma+Berufskrankheit.80010040.eng.abstr_task1	Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please typing these entity words according to sentence: ulna, treatment, radius fractures Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The significance of the styloid process of the ulna in the treatment of distal radius fractures .	[ "The", "significance", "of", "the", "styloid", "process", "of", "the", "ulna", "in", "the", "treatment", "of", "distal", "radius", "fractures", "." ]	[ "umlsterm" ]
ulna, treatment, radius fractures	Trauma+Berufskrankheit.80010040.eng.abstr_task2	Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The significance of the styloid process of the ulna in the treatment of distal radius fractures .	[ "The", "significance", "of", "the", "styloid", "process", "of", "the", "ulna", "in", "the", "treatment", "of", "distal", "radius", "fractures", "." ]	[ "umlsterm" ]
dual - axis rotational coronary angiography ( XPERSWING ) is a Intervention_Physical, conventional is a Intervention_Physical, Rotational angiography is a Intervention_Physical, conventional coronary angiography ( A ) vs rotational angiography is a Intervention_Physical, amount of contrast administered is a Outcome_Other, total procedure time is a Outcome_Other, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized is a Participant_Condition, radiation exposure is a Outcome_Other, Angioplasty is a Outcome_Physical, Contrast reduction is a Outcome_Other, contrast dose is a Outcome_Other	54342_task0	Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Other, Outcome_Physical, Participant_Condition	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .	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dual - axis rotational coronary angiography ( XPERSWING ) is a Intervention_Physical, conventional is a Intervention_Physical, Rotational angiography is a Intervention_Physical, conventional coronary angiography ( A ) vs rotational angiography is a Intervention_Physical, amount of contrast administered is a Outcome_Other, total procedure time is a Outcome_Other, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized is a Participant_Condition, radiation exposure is a Outcome_Other, Angioplasty is a Outcome_Physical, Contrast reduction is a Outcome_Other, contrast dose is a Outcome_Other	54342_task1	Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please typing these entity words according to sentence: dual - axis rotational coronary angiography ( XPERSWING ), conventional, Rotational angiography, conventional coronary angiography ( A ) vs rotational angiography, amount of contrast administered, total procedure time, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized, radiation exposure, Angioplasty, Contrast reduction, contrast dose Options: Intervention_Physical, Outcome_Other, Outcome_Physical, Participant_Condition	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .	[ "Comparison", "of", "dual", "-", "axis", "rotational", "coronary", "angiography", "(", "XPERSWING", ")", "versus", "conventional", "technique", "in", "routine", "practice", ".", "INTRODUCTION", "AND", "OBJECTIVES", "Coronary", "angiography", "is", "the", "gold", "standard", "for", "the", "study", "of", "coronary", "artery", "disease", ".", "This", "technique", "requires", "several", "orthogonal", "projections", ".", "Rotational", "angiography", "is", "a", "new", "technique", "which", "involves", "pre", "-", "set", "rotation", "of", "the", "X", "-", "ray", "tube", "around", "the", "patient", "and", "allows", "visualization", "of", "each", "coronary", "artery", "in", "different", "views", ",", "using", "a", "single", "contrast", "injection", ".", "The", "purpose", "of", "this", "study", "was", "to", "compare", "conventional", "coronary", "angiography", "(", "A", ")", "vs", "rotational", "angiography", "(", "B", ")", ",", "focusing", "on", "radiation", "dose", ",", "amount", "of", "contrast", "administered", ",", "and", "total", "procedure", "time", "for", "both", "diagnostic", "and", "therapeutic", "percutaneous", "coronary", "interventions", ".", "METHODS", "Prospective", "study", "of", "104", "consecutive", "patients", "undergoing", "coronary", "angiography", "who", "were", "randomized", "to", "one", "of", "these", "techniques", ".", "RESULTS", "We", "found", "a", "significant", "reduction", "in", "the", "amount", "of", "contrast", "administered", "(", "A", "vs", "B", ",", "93.1", "[", "41.7", "]", "vs", "50.9", "[", "14.7", "]", "mL", ";", "P", "<", ".0001", ")", "and", "radiation", "exposure", "(", "27.6", "[", "11.5", "]", "vs", "18", "[", "6.4", "]", "mGycm", "(", "2", ")", ";", "P", "<", ".0001", ")", ".", "A", "significant", "increase", "in", "total", "procedure", "time", "was", "noted", "in", "the", "rotational", "angiography", "arm", ".", "However", ",", "when", "only", "the", "last", "50", "patients", "were", "analyzed", ",", "we", "found", "no", "difference", "in", "procedure", "time", "between", "the", "groups", ",", "probably", "related", "to", "the", "learning", "curve", "of", "the", "operators", ".", "Angioplasty", "was", "performed", "in", "29", "patients", "in", "group", "A", "and", "28", "patients", "in", "group", "B", ".", "Contrast", "reduction", "was", "maintained", "in", "the", "rotational", "angiography", "group", "compared", "to", "the", "conventional", "technique", "(", "A", "vs", "B", ",", "335.1", "[", "192.1", "]", "vs", "238.5", "[", "114.4", "]", "mL", ";", "P=.02", ")", ".", "CONCLUSIONS", "The", "rotational", "angiography", "technique", "leads", "to", "a", "significant", "decrease", "in", "radiation", "exposure", "and", "contrast", "dose", "administered", "for", "diagnostic", "procedures", "when", "compared", "to", "conventional", "coronary", "angiography", ".", "In", "patients", "who", "undergo", "percutaneous", "coronary", "intervention", ",", "contrast", "reduction", "remains", "significant", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Other", "Outcome_Physical" ]
dual - axis rotational coronary angiography ( XPERSWING ), conventional, Rotational angiography, conventional coronary angiography ( A ) vs rotational angiography, amount of contrast administered, total procedure time, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized, radiation exposure, Angioplasty, Contrast reduction, contrast dose	54342_task2	Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .	[ "Comparison", "of", "dual", "-", "axis", "rotational", "coronary", "angiography", "(", "XPERSWING", ")", "versus", "conventional", "technique", "in", "routine", "practice", ".", "INTRODUCTION", "AND", "OBJECTIVES", "Coronary", "angiography", "is", "the", "gold", "standard", "for", "the", "study", "of", "coronary", "artery", "disease", ".", "This", "technique", "requires", "several", "orthogonal", "projections", ".", "Rotational", "angiography", "is", "a", "new", "technique", "which", "involves", "pre", "-", "set", "rotation", "of", "the", "X", "-", "ray", "tube", "around", "the", "patient", "and", "allows", "visualization", "of", "each", "coronary", "artery", "in", "different", "views", ",", "using", "a", "single", "contrast", "injection", ".", "The", "purpose", "of", "this", "study", "was", "to", "compare", "conventional", "coronary", "angiography", "(", "A", ")", "vs", "rotational", "angiography", "(", "B", ")", ",", "focusing", "on", "radiation", "dose", ",", "amount", "of", "contrast", "administered", ",", "and", "total", "procedure", "time", "for", "both", "diagnostic", "and", "therapeutic", "percutaneous", "coronary", "interventions", ".", "METHODS", "Prospective", "study", "of", "104", "consecutive", "patients", "undergoing", "coronary", "angiography", "who", "were", "randomized", "to", "one", "of", "these", "techniques", ".", "RESULTS", "We", "found", "a", "significant", "reduction", "in", "the", "amount", "of", "contrast", "administered", "(", "A", "vs", "B", ",", "93.1", "[", "41.7", "]", "vs", "50.9", "[", "14.7", "]", "mL", ";", "P", "<", ".0001", ")", "and", "radiation", "exposure", "(", "27.6", "[", "11.5", "]", "vs", "18", "[", "6.4", "]", "mGycm", "(", "2", ")", ";", "P", "<", ".0001", ")", ".", "A", "significant", "increase", "in", "total", "procedure", "time", "was", "noted", "in", "the", "rotational", "angiography", "arm", ".", "However", ",", "when", "only", "the", "last", "50", "patients", "were", "analyzed", ",", "we", "found", "no", "difference", "in", "procedure", "time", "between", "the", "groups", ",", "probably", "related", "to", "the", "learning", "curve", "of", "the", "operators", ".", "Angioplasty", "was", "performed", "in", "29", "patients", "in", "group", "A", "and", "28", "patients", "in", "group", "B", ".", "Contrast", "reduction", "was", "maintained", "in", "the", "rotational", "angiography", "group", "compared", "to", "the", "conventional", "technique", "(", "A", "vs", "B", ",", "335.1", "[", "192.1", "]", "vs", "238.5", "[", "114.4", "]", "mL", ";", "P=.02", ")", ".", "CONCLUSIONS", "The", "rotational", "angiography", "technique", "leads", "to", "a", "significant", "decrease", "in", "radiation", "exposure", "and", "contrast", "dose", "administered", "for", "diagnostic", "procedures", "when", "compared", "to", "conventional", "coronary", "angiography", ".", "In", "patients", "who", "undergo", "percutaneous", "coronary", "intervention", ",", "contrast", "reduction", "remains", "significant", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Other", "Outcome_Physical" ]
Mitogen activation is an other_name, human peripheral T lymphocytes is a cell_type, cyclic AMP response element - binding protein nuclear complexes is a protein_complex	12099_task0	Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_complex, cell_type, other_name	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.	[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]	[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]
Mitogen activation is an other_name, human peripheral T lymphocytes is a cell_type, cyclic AMP response element - binding protein nuclear complexes is a protein_complex	12099_task1	Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please typing these entity words according to sentence: Mitogen activation, human peripheral T lymphocytes, cyclic AMP response element - binding protein nuclear complexes Options: protein_complex, cell_type, other_name	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.	[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]	[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]
Mitogen activation, human peripheral T lymphocytes, cyclic AMP response element - binding protein nuclear complexes	12099_task2	Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please extract entity words from the input sentence	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.	[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]	[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]
rehabilitation is an umlsterm, defects is an umlsterm, malformations is an umlsterm, development is an umlsterm, silicones is an umlsterm, titanium is an umlsterm, prostheses is an umlsterm, production is an umlsterm, techniques is an umlsterm, defects is an umlsterm, ear is an umlsterm, nose is an umlsterm, orbit is an umlsterm, prostheses is an umlsterm, plastic surgery is an umlsterm, recognition is an umlsterm, recurrences is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, contraindications is an umlsterm, patients is an umlsterm, prostheses is an umlsterm, University is an umlsterm, Germany is an umlsterm	HNO.80460569.eng.abstr_task0	Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .	[ "The", "prosthetic", "rehabilitation", "of", "cranio", "-", "facial", "defects", "and", "malformations", "has", "made", "enormous", "progress", "with", "the", "development", "of", "currently", "available", "silicones", "and", "the", "discovery", "of", "titanium", "as", "an", "optimally", "bicompatible", "implant", "material", ".", "This", "allows", "for", "a", "reliable", ",", "solid", "fixation", "of", "cranio", "-", "facial", "prostheses", ",", "which", ",", "due", "to", "modern", "production", "techniques", ",", "give", "outstanding", "camouflage", "to", "defects", ".", "To", "reconstruct", "such", "complex", "aesthetic", "entities", "as", "the", "ear", ",", "nose", "and", "orbit", ",", "bone", "-", "anchored", "prostheses", "now", "represent", "more", "than", "just", "an", "alternative", "to", "plastic", "surgery", ".", "Their", "removal", "also", "allows", "early", "recognition", "of", "recurrences", "following", "tumor", "surgery", ".", "The", "principles", "of", "implantology", "and", "all", "commercially", "available", "systems", "are", "presented", ",", "as", "well", "as", "indications", ",", "contraindications", "and", "our", "personal", "experience", "with", "120", "patients", "who", "received", "bone", "-", "anchored", "prostheses", "at", "the", "ENT", "Department", "of", "the", "University", "of", "Saarland", "in", "Homburg", ",", "Germany", "." ]	[ "umlsterm" ]
rehabilitation is an umlsterm, defects is an umlsterm, malformations is an umlsterm, development is an umlsterm, silicones is an umlsterm, titanium is an umlsterm, prostheses is an umlsterm, production is an umlsterm, techniques is an umlsterm, defects is an umlsterm, ear is an umlsterm, nose is an umlsterm, orbit is an umlsterm, prostheses is an umlsterm, plastic surgery is an umlsterm, recognition is an umlsterm, recurrences is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, contraindications is an umlsterm, patients is an umlsterm, prostheses is an umlsterm, University is an umlsterm, Germany is an umlsterm	HNO.80460569.eng.abstr_task1	Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please typing these entity words according to sentence: rehabilitation, defects, malformations, development, silicones, titanium, prostheses, production, techniques, defects, ear, nose, orbit, prostheses, plastic surgery, recognition, recurrences, tumor, surgery, contraindications, patients, prostheses, University, Germany Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .	[ "The", "prosthetic", "rehabilitation", "of", "cranio", "-", "facial", "defects", "and", "malformations", "has", "made", "enormous", "progress", "with", "the", "development", "of", "currently", "available", "silicones", "and", "the", "discovery", "of", "titanium", "as", "an", "optimally", "bicompatible", "implant", "material", ".", "This", "allows", "for", "a", "reliable", ",", "solid", "fixation", "of", "cranio", "-", "facial", "prostheses", ",", "which", ",", "due", "to", "modern", "production", "techniques", ",", "give", "outstanding", "camouflage", "to", "defects", ".", "To", "reconstruct", "such", "complex", "aesthetic", "entities", "as", "the", "ear", ",", "nose", "and", "orbit", ",", "bone", "-", "anchored", "prostheses", "now", "represent", "more", "than", "just", "an", "alternative", "to", "plastic", "surgery", ".", "Their", "removal", "also", "allows", "early", "recognition", "of", "recurrences", "following", "tumor", "surgery", ".", "The", "principles", "of", "implantology", "and", "all", "commercially", "available", "systems", "are", "presented", ",", "as", "well", "as", "indications", ",", "contraindications", "and", "our", "personal", "experience", "with", "120", "patients", "who", "received", "bone", "-", "anchored", "prostheses", "at", "the", "ENT", "Department", "of", "the", "University", "of", "Saarland", "in", "Homburg", ",", "Germany", "." ]	[ "umlsterm" ]
rehabilitation, defects, malformations, development, silicones, titanium, prostheses, production, techniques, defects, ear, nose, orbit, prostheses, plastic surgery, recognition, recurrences, tumor, surgery, contraindications, patients, prostheses, University, Germany	HNO.80460569.eng.abstr_task2	Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .	[ "The", "prosthetic", "rehabilitation", "of", "cranio", "-", "facial", "defects", "and", "malformations", "has", "made", "enormous", "progress", "with", "the", "development", "of", "currently", "available", "silicones", "and", "the", "discovery", "of", "titanium", "as", "an", "optimally", "bicompatible", "implant", "material", ".", "This", "allows", "for", "a", "reliable", ",", "solid", "fixation", "of", "cranio", "-", "facial", "prostheses", ",", "which", ",", "due", "to", "modern", "production", "techniques", ",", "give", "outstanding", "camouflage", "to", "defects", ".", "To", "reconstruct", "such", "complex", "aesthetic", "entities", "as", "the", "ear", ",", "nose", "and", "orbit", ",", "bone", "-", "anchored", "prostheses", "now", "represent", "more", "than", "just", "an", "alternative", "to", "plastic", "surgery", ".", "Their", "removal", "also", "allows", "early", "recognition", "of", "recurrences", "following", "tumor", "surgery", ".", "The", "principles", "of", "implantology", "and", "all", "commercially", "available", "systems", "are", "presented", ",", "as", "well", "as", "indications", ",", "contraindications", "and", "our", "personal", "experience", "with", "120", "patients", "who", "received", "bone", "-", "anchored", "prostheses", "at", "the", "ENT", "Department", "of", "the", "University", "of", "Saarland", "in", "Homburg", ",", "Germany", "." ]	[ "umlsterm" ]
Ikaros is a protein_molecule, Aiolos is a protein_molecule, histone deacetylase complexes is a protein_complex	39289_task0	Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_complex, protein_molecule	[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]	[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]
Ikaros is a protein_molecule, Aiolos is a protein_molecule, histone deacetylase complexes is a protein_complex	39289_task1	Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please typing these entity words according to sentence: Ikaros, Aiolos, histone deacetylase complexes Options: protein_complex, protein_molecule	[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]	[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]
Ikaros, Aiolos, histone deacetylase complexes	39289_task2	Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]	[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]
histologic is an umlsterm, determination is an umlsterm, tissue is an umlsterm, anaplasia is an umlsterm, malignancy is an umlsterm, gliomas is an umlsterm, mitoses is an umlsterm, tumor is an umlsterm, necrosis is an umlsterm, weighting is an umlsterm, criteria is an umlsterm, weighting is an umlsterm, procedure is an umlsterm, classification is an umlsterm, brain tumors is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, mixed gliomas is an umlsterm, glioma is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, glioma is an umlsterm, tumor is an umlsterm, contrast is an umlsterm, MRI is an umlsterm, criterion is an umlsterm, tumor is an umlsterm, malignancy is an umlsterm	DerPathologe.80190259.eng.abstr_task0	Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .	[ "The", "histologic", "determination", "of", "the", "degree", "of", "tissue", "anaplasia", "and", "grade", "of", "malignancy", "of", "gliomas", "is", "based", "upon", "qualitative", "histological", "features", "(", "nuclear", "pleomorphism", ",", "mitoses", ",", "endothelial", "proliferation", ",", "tumor", "necrosis", ")", ".", "This", "grading", "approach", "is", "influenced", "by", "the", "subjective", "interpretation", "of", "the", "pathologist", ",", "especially", "concerning", "the", "weighting", "of", "criteria", "(", "scant", ",", "moderate", ",", "pronounced", ")", ".", "An", "observer", "-", "independent", "approach", "seems", "to", "be", "feasible", "by", "abandoning", "the", "concept", "of", "parameter", "weighting", "in", "favor", "of", "an", "binary", "approach", "noting", "only", "the", "presence", "or", "absence", "of", "these", "structure", "parameters", ".", "This", "grading", "procedure", "is", "recognized", "in", "the", "revised", "WHO", "classification", "of", "brain", "tumors", "for", "common", "type", "astrocytomas", "(", "Ste", ".", "Anne", "-", "Mayo", "System", ",", "SAMS", ")", ".", "Our", "results", "indicate", "that", "a", "similiar", "approach", "is", "also", "suitable", "for", "grading", "purposes", "of", "oligodendrogliomas", "and", "mixed", "gliomas", ".", "Our", "recent", "investigations", "on", "glioma", "grading", "showed", ",", "both", "for", "astrocytomas", "and", "oligodendrogliomas", ",", "that", "a", "two", "-", "tiered", "grading", "scheme", "distinguishing", "only", "\"", "low", "-", "grade", "\"", "and", "\"", "high", "-", "grade", "\"", "cases", "was", "prognostically", "relevant", ".", "For", "all", "glioma", "entities", "the", "onset", "of", "tumor", "angiogenesis", "with", "endothelial", "proliferation", "and", "contrast", "enhancement", "in", "CT", "and", "MRI", "seems", "to", "be", "the", "key", "criterion", "indicating", "irreversible", "tumor", "progression", "to", "the", "\"", "high", "\"", "malignancy", "grade", "." ]	[ "umlsterm" ]
histologic is an umlsterm, determination is an umlsterm, tissue is an umlsterm, anaplasia is an umlsterm, malignancy is an umlsterm, gliomas is an umlsterm, mitoses is an umlsterm, tumor is an umlsterm, necrosis is an umlsterm, weighting is an umlsterm, criteria is an umlsterm, weighting is an umlsterm, procedure is an umlsterm, classification is an umlsterm, brain tumors is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, mixed gliomas is an umlsterm, glioma is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, glioma is an umlsterm, tumor is an umlsterm, contrast is an umlsterm, MRI is an umlsterm, criterion is an umlsterm, tumor is an umlsterm, malignancy is an umlsterm	DerPathologe.80190259.eng.abstr_task1	Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please typing these entity words according to sentence: histologic, determination, tissue, anaplasia, malignancy, gliomas, mitoses, tumor, necrosis, weighting, criteria, weighting, procedure, classification, brain tumors, astrocytomas, oligodendrogliomas, mixed gliomas, glioma, astrocytomas, oligodendrogliomas, glioma, tumor, contrast, MRI, criterion, tumor, malignancy Options: umlsterm	[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .	[ "The", "histologic", "determination", "of", "the", "degree", "of", "tissue", "anaplasia", "and", "grade", "of", "malignancy", "of", "gliomas", "is", "based", "upon", "qualitative", "histological", "features", "(", "nuclear", "pleomorphism", ",", "mitoses", ",", "endothelial", "proliferation", ",", "tumor", "necrosis", ")", ".", "This", "grading", "approach", "is", "influenced", "by", "the", "subjective", "interpretation", "of", "the", "pathologist", ",", "especially", "concerning", "the", "weighting", "of", "criteria", "(", "scant", ",", "moderate", ",", "pronounced", ")", ".", "An", "observer", "-", "independent", "approach", "seems", "to", "be", "feasible", "by", "abandoning", "the", "concept", "of", "parameter", "weighting", "in", "favor", "of", "an", "binary", "approach", "noting", "only", "the", "presence", "or", "absence", "of", "these", "structure", "parameters", ".", "This", "grading", "procedure", "is", "recognized", "in", "the", "revised", "WHO", "classification", "of", "brain", "tumors", "for", "common", "type", "astrocytomas", "(", "Ste", ".", "Anne", "-", "Mayo", "System", ",", "SAMS", ")", ".", "Our", "results", "indicate", "that", "a", "similiar", "approach", "is", "also", "suitable", "for", "grading", "purposes", "of", "oligodendrogliomas", "and", "mixed", "gliomas", ".", "Our", "recent", "investigations", "on", "glioma", "grading", "showed", ",", "both", "for", "astrocytomas", "and", "oligodendrogliomas", ",", "that", "a", "two", "-", "tiered", "grading", "scheme", "distinguishing", "only", "\"", "low", "-", "grade", "\"", "and", "\"", "high", "-", "grade", "\"", "cases", "was", "prognostically", "relevant", ".", "For", "all", "glioma", "entities", "the", "onset", "of", "tumor", "angiogenesis", "with", "endothelial", "proliferation", "and", "contrast", "enhancement", "in", "CT", "and", "MRI", "seems", "to", "be", "the", "key", "criterion", "indicating", "irreversible", "tumor", "progression", "to", "the", "\"", "high", "\"", "malignancy", "grade", "." ]	[ "umlsterm" ]
histologic, determination, tissue, anaplasia, malignancy, gliomas, mitoses, tumor, necrosis, weighting, criteria, weighting, procedure, classification, brain tumors, astrocytomas, oligodendrogliomas, mixed gliomas, glioma, astrocytomas, oligodendrogliomas, glioma, tumor, contrast, MRI, criterion, tumor, malignancy	DerPathologe.80190259.eng.abstr_task2	Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .	[ "The", "histologic", "determination", "of", "the", "degree", "of", "tissue", "anaplasia", "and", "grade", "of", "malignancy", "of", "gliomas", "is", "based", "upon", "qualitative", "histological", "features", "(", "nuclear", "pleomorphism", ",", "mitoses", ",", "endothelial", "proliferation", ",", "tumor", "necrosis", ")", ".", "This", "grading", "approach", "is", "influenced", "by", "the", "subjective", "interpretation", "of", "the", "pathologist", ",", "especially", "concerning", "the", "weighting", "of", "criteria", "(", "scant", ",", "moderate", ",", "pronounced", ")", ".", "An", "observer", "-", "independent", "approach", "seems", "to", "be", "feasible", "by", "abandoning", "the", "concept", "of", "parameter", "weighting", "in", "favor", "of", "an", "binary", "approach", "noting", "only", "the", "presence", "or", "absence", "of", "these", "structure", "parameters", ".", "This", "grading", "procedure", "is", "recognized", "in", "the", "revised", "WHO", "classification", "of", "brain", "tumors", "for", "common", "type", "astrocytomas", "(", "Ste", ".", "Anne", "-", "Mayo", "System", ",", "SAMS", ")", ".", "Our", "results", "indicate", "that", "a", "similiar", "approach", "is", "also", "suitable", "for", "grading", "purposes", "of", "oligodendrogliomas", "and", "mixed", "gliomas", ".", "Our", "recent", "investigations", "on", "glioma", "grading", "showed", ",", "both", "for", "astrocytomas", "and", "oligodendrogliomas", ",", "that", "a", "two", "-", "tiered", "grading", "scheme", "distinguishing", "only", "\"", "low", "-", "grade", "\"", "and", "\"", "high", "-", "grade", "\"", "cases", "was", "prognostically", "relevant", ".", "For", "all", "glioma", "entities", "the", "onset", "of", "tumor", "angiogenesis", "with", "endothelial", "proliferation", "and", "contrast", "enhancement", "in", "CT", "and", "MRI", "seems", "to", "be", "the", "key", "criterion", "indicating", "irreversible", "tumor", "progression", "to", "the", "\"", "high", "\"", "malignancy", "grade", "." ]	[ "umlsterm" ]
Kerlone is a BRAND, cimetidine is a DRUG, nifedipine is a DRUG, chlorthalidone is a DRUG, hydrochlorothiazide is a DRUG, Kerlone is a BRAND, anticoagulant is a GROUP, warfarin is a DRUG, warfarin is a DRUG, reserpine is a DRUG, beta - blocking is a DRUG, beta - adrenergic receptor blocking agent is a GROUP, beta - blockers is a GROUP, clonidine is a DRUG, beta - blocker is a GROUP, clonidine is a DRUG, calcium antagonists is a GROUP, beta - adrenergic blocking agents is a GROUP, beta - adrenergic blocking agents is a GROUP, calcium antagonist is a GROUP, calcium antagonist is a GROUP, dihydropyridine derivative is a GROUP, nifedipine is a DRUG, verapamil is a DRUG, diltiazem is a DRUG, beta - blockers is a GROUP, epinephrine is a DRUG, beta - blockers is a GROUP, beta - blockers is a GROUP, epinephrine is a DRUG	Betaxolol_ddi_task0	Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG, BRAND	[ "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O" ]	The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.	[ "The", "following", "drugs", "have", "been", "coadministered", "with", "Kerlone", "and", "have", "not", "altered", "its", "pharmacokinetics", ":", "cimetidine", ",", "nifedipine", ",", "chlorthalidone", ",", "and", "hydrochlorothiazide", ".", "Concomitant", "administration", "of", "Kerlone", "with", "the", "oral", "anticoagulant", "warfarin", "has", "been", "shown", "not", "to", "potentiate", "the", "anticoagulant", "effect", "of", "warfarin", ".", "Catecholamine", "-", "depleting", "drugs", "(", "e.g", ".", ",", "reserpine", ")", "may", "have", "an", "additive", "effect", "when", "given", "with", "beta", "-", "blocking", "agents", ".", "Patients", "treated", "with", "a", "beta", "-", "adrenergic", "receptor", "blocking", "agent", "plus", "a", "catecholamine", "depletor", "should", "therefore", "be", "closely", "observed", "for", "evidence", "of", "hypotension", "or", "marked", "bradycardia", ",", "which", "may", "produce", "vertigo", ",", "syncope", ",", "or", "postural", "hypotension", ".", "Should", "it", "be", "decided", "to", "discontinue", "therapy", "in", "patients", "receiving", "beta", "-", "blockers", "and", "clonidine", "concurrently", ",", "the", "beta", "-", "blocker", "should", "be", "discontinued", "slowly", "over", "several", "days", "before", "the", "gradual", "withdrawal", "of", "clonidine", ".", "Literature", "reports", "suggest", "that", "oral", "calcium", "antagonists", "may", "be", "used", "in", "combination", "with", "beta", "-", "adrenergic", "blocking", "agents", "when", "heart", "function", "is", "normal", ",", "but", "should", "be", "avoided", "in", "patients", "with", "impaired", "cardiac", "function", ".", "Hypotension", ",", "AV", "conduction", "disturbances", ",", "and", "left", "ventricular", "failure", "have", "been", "reported", "in", "some", "patients", "receiving", "beta", "-", "adrenergic", "blocking", "agents", "when", "an", "oral", "calcium", "antagonist", "was", "added", "to", "the", "treatment", "regimen", ".", "Hypotension", "was", "more", "likely", "to", "occur", "if", "the", "calcium", "antagonist", "were", "a", "dihydropyridine", "derivative", ",", "e.g", ".", ",", "nifedipine", ",", "while", "left", "ventricular", "failure", "and", "AV", "conduction", "disturbances", ",", "including", "complete", "heart", "block", ",", "were", "more", "likely", "to", "occur", "with", "either", "verapamil", "or", "diltiazem", ".", "Risk", "of", "Anaphylactic", "Reaction", ":", "Although", "it", "is", "known", "that", "patients", "on", "beta", "-", "blockers", "may", "be", "refractory", "to", "epinephrine", "in", "the", "treatment", "of", "anaphylactic", "shock", ",", "beta", "-", "blockers", "can", ",", "in", "addition", ",", "interfere", "with", "the", "modulation", "of", "allergic", "reaction", "and", "lead", "to", "an", "increased", "severity", "and", "/", "or", "frequency", "of", "attacks", ".", "Severe", "allergic", "reactions", "including", "anaphylaxis", "have", "been", "reported", "in", "patients", "exposed", "to", "a", "variety", "of", "allergens", "either", "by", "repeated", "challenge", ",", "or", "accidental", "contact", ",", "and", "with", "diagnostic", "or", "therapeutic", "agents", "while", "receiving", "beta", "-", "blockers", ".", "Such", "patients", "may", "be", "unresponsive", "to", "the", "usual", "doses", "of", "epinephrine", "used", "to", "treat", "allergic", "reaction", "." ]	[ "GROUP", "DRUG", "BRAND" ]
Kerlone is a BRAND, cimetidine is a DRUG, nifedipine is a DRUG, chlorthalidone is a DRUG, hydrochlorothiazide is a DRUG, Kerlone is a BRAND, anticoagulant is a GROUP, warfarin is a DRUG, warfarin is a DRUG, reserpine is a DRUG, beta - blocking is a DRUG, beta - adrenergic receptor blocking agent is a GROUP, beta - blockers is a GROUP, clonidine is a DRUG, beta - blocker is a GROUP, clonidine is a DRUG, calcium antagonists is a GROUP, beta - adrenergic blocking agents is a GROUP, beta - adrenergic blocking agents is a GROUP, calcium antagonist is a GROUP, calcium antagonist is a GROUP, dihydropyridine derivative is a GROUP, nifedipine is a DRUG, verapamil is a DRUG, diltiazem is a DRUG, beta - blockers is a GROUP, epinephrine is a DRUG, beta - blockers is a GROUP, beta - blockers is a GROUP, epinephrine is a DRUG	Betaxolol_ddi_task1	Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please typing these entity words according to sentence: Kerlone, cimetidine, nifedipine, chlorthalidone, hydrochlorothiazide, Kerlone, anticoagulant, warfarin, warfarin, reserpine, beta - blocking, beta - adrenergic receptor blocking agent, beta - blockers, clonidine, beta - blocker, clonidine, calcium antagonists, beta - adrenergic blocking agents, beta - adrenergic blocking agents, calcium antagonist, calcium antagonist, dihydropyridine derivative, nifedipine, verapamil, diltiazem, beta - blockers, epinephrine, beta - blockers, beta - blockers, epinephrine Options: GROUP, DRUG, BRAND	[ "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O" ]	The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.	[ "The", "following", "drugs", "have", "been", "coadministered", "with", "Kerlone", "and", "have", "not", "altered", "its", "pharmacokinetics", ":", "cimetidine", ",", "nifedipine", ",", "chlorthalidone", ",", "and", "hydrochlorothiazide", ".", "Concomitant", "administration", "of", "Kerlone", "with", "the", "oral", "anticoagulant", "warfarin", "has", "been", "shown", "not", "to", "potentiate", "the", "anticoagulant", "effect", "of", "warfarin", ".", "Catecholamine", "-", "depleting", "drugs", "(", "e.g", ".", ",", "reserpine", ")", "may", "have", "an", "additive", "effect", "when", "given", "with", "beta", "-", "blocking", "agents", ".", "Patients", "treated", "with", "a", "beta", "-", "adrenergic", "receptor", "blocking", "agent", "plus", "a", "catecholamine", "depletor", "should", "therefore", "be", "closely", "observed", "for", "evidence", "of", "hypotension", "or", "marked", "bradycardia", ",", "which", "may", "produce", "vertigo", ",", "syncope", ",", "or", "postural", "hypotension", ".", "Should", "it", "be", "decided", "to", "discontinue", "therapy", "in", "patients", "receiving", "beta", "-", "blockers", "and", "clonidine", "concurrently", ",", "the", "beta", "-", "blocker", "should", "be", "discontinued", "slowly", "over", "several", "days", "before", "the", "gradual", "withdrawal", "of", "clonidine", ".", "Literature", "reports", "suggest", "that", "oral", "calcium", "antagonists", "may", "be", "used", "in", "combination", "with", "beta", "-", "adrenergic", "blocking", "agents", "when", "heart", "function", "is", "normal", ",", "but", "should", "be", "avoided", "in", "patients", "with", "impaired", "cardiac", "function", ".", "Hypotension", ",", "AV", "conduction", "disturbances", ",", "and", "left", "ventricular", "failure", "have", "been", "reported", "in", "some", "patients", "receiving", "beta", "-", "adrenergic", "blocking", "agents", "when", "an", "oral", "calcium", "antagonist", "was", "added", "to", "the", "treatment", "regimen", ".", "Hypotension", "was", "more", "likely", "to", "occur", "if", "the", "calcium", "antagonist", "were", "a", "dihydropyridine", "derivative", ",", "e.g", ".", ",", "nifedipine", ",", "while", "left", "ventricular", "failure", "and", "AV", "conduction", "disturbances", ",", "including", "complete", "heart", "block", ",", "were", "more", "likely", "to", "occur", "with", "either", "verapamil", "or", "diltiazem", ".", "Risk", "of", "Anaphylactic", "Reaction", ":", "Although", "it", "is", "known", "that", "patients", "on", "beta", "-", "blockers", "may", "be", "refractory", "to", "epinephrine", "in", "the", "treatment", "of", "anaphylactic", "shock", ",", "beta", "-", "blockers", "can", ",", "in", "addition", ",", "interfere", "with", "the", "modulation", "of", "allergic", "reaction", "and", "lead", "to", "an", "increased", "severity", "and", "/", "or", "frequency", "of", "attacks", ".", "Severe", "allergic", "reactions", "including", "anaphylaxis", "have", "been", "reported", "in", "patients", "exposed", "to", "a", "variety", "of", "allergens", "either", "by", "repeated", "challenge", ",", "or", "accidental", "contact", ",", "and", "with", "diagnostic", "or", "therapeutic", "agents", "while", "receiving", "beta", "-", "blockers", ".", "Such", "patients", "may", "be", "unresponsive", "to", "the", "usual", "doses", "of", "epinephrine", "used", "to", "treat", "allergic", "reaction", "." ]	[ "GROUP", "DRUG", "BRAND" ]
Kerlone, cimetidine, nifedipine, chlorthalidone, hydrochlorothiazide, Kerlone, anticoagulant, warfarin, warfarin, reserpine, beta - blocking, beta - adrenergic receptor blocking agent, beta - blockers, clonidine, beta - blocker, clonidine, calcium antagonists, beta - adrenergic blocking agents, beta - adrenergic blocking agents, calcium antagonist, calcium antagonist, dihydropyridine derivative, nifedipine, verapamil, diltiazem, beta - blockers, epinephrine, beta - blockers, beta - blockers, epinephrine	Betaxolol_ddi_task2	Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "B-GROUP", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O" ]	The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.	[ "The", "following", "drugs", "have", "been", "coadministered", "with", "Kerlone", "and", "have", "not", "altered", "its", "pharmacokinetics", ":", "cimetidine", ",", "nifedipine", ",", "chlorthalidone", ",", "and", "hydrochlorothiazide", ".", "Concomitant", "administration", "of", "Kerlone", "with", "the", "oral", "anticoagulant", "warfarin", "has", "been", "shown", "not", "to", "potentiate", "the", "anticoagulant", "effect", "of", "warfarin", ".", "Catecholamine", "-", "depleting", "drugs", "(", "e.g", ".", ",", "reserpine", ")", "may", "have", "an", "additive", "effect", "when", "given", "with", "beta", "-", "blocking", "agents", ".", "Patients", "treated", "with", "a", "beta", "-", "adrenergic", "receptor", "blocking", "agent", "plus", "a", "catecholamine", "depletor", "should", "therefore", "be", "closely", "observed", "for", "evidence", "of", "hypotension", "or", "marked", "bradycardia", ",", "which", "may", "produce", "vertigo", ",", "syncope", ",", "or", "postural", "hypotension", ".", "Should", "it", "be", "decided", "to", "discontinue", "therapy", "in", "patients", "receiving", "beta", "-", "blockers", "and", "clonidine", "concurrently", ",", "the", "beta", "-", "blocker", "should", "be", "discontinued", "slowly", "over", "several", "days", "before", "the", "gradual", "withdrawal", "of", "clonidine", ".", "Literature", "reports", "suggest", "that", "oral", "calcium", "antagonists", "may", "be", "used", "in", "combination", "with", "beta", "-", "adrenergic", "blocking", "agents", "when", "heart", "function", "is", "normal", ",", "but", "should", "be", "avoided", "in", "patients", "with", "impaired", "cardiac", "function", ".", "Hypotension", ",", "AV", "conduction", "disturbances", ",", "and", "left", "ventricular", "failure", "have", "been", "reported", "in", "some", "patients", "receiving", "beta", "-", "adrenergic", "blocking", "agents", "when", "an", "oral", "calcium", "antagonist", "was", "added", "to", "the", "treatment", "regimen", ".", "Hypotension", "was", "more", "likely", "to", "occur", "if", "the", "calcium", "antagonist", "were", "a", "dihydropyridine", "derivative", ",", "e.g", ".", ",", "nifedipine", ",", "while", "left", "ventricular", "failure", "and", "AV", "conduction", "disturbances", ",", "including", "complete", "heart", "block", ",", "were", "more", "likely", "to", "occur", "with", "either", "verapamil", "or", "diltiazem", ".", "Risk", "of", "Anaphylactic", "Reaction", ":", "Although", "it", "is", "known", "that", "patients", "on", "beta", "-", "blockers", "may", "be", "refractory", "to", "epinephrine", "in", "the", "treatment", "of", "anaphylactic", "shock", ",", "beta", "-", "blockers", "can", ",", "in", "addition", ",", "interfere", "with", "the", "modulation", "of", "allergic", "reaction", "and", "lead", "to", "an", "increased", "severity", "and", "/", "or", "frequency", "of", "attacks", ".", "Severe", "allergic", "reactions", "including", "anaphylaxis", "have", "been", "reported", "in", "patients", "exposed", "to", "a", "variety", "of", "allergens", "either", "by", "repeated", "challenge", ",", "or", "accidental", "contact", ",", "and", "with", "diagnostic", "or", "therapeutic", "agents", "while", "receiving", "beta", "-", "blockers", ".", "Such", "patients", "may", "be", "unresponsive", "to", "the", "usual", "doses", "of", "epinephrine", "used", "to", "treat", "allergic", "reaction", "." ]	[ "GROUP", "DRUG", "BRAND" ]
NADA is a compound, cytochrome P450 is a protein	DS.d1295_task0	Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.	[ "To", "investigate", "the", "metabolism", "of", "NADA", "through", "the", "cytochrome", "P450", "(", "CYP450", ")", "metabolic", "pathway", ",", "we", "studied", "the", "in", "vitro", "rat", "liver", "microsomal", "production", "of", "hydroxylated", "metabolites", "and", "their", "activity", "at", "recombinant", "human", "TRPV(1", ")", "receptors", "." ]	[ "protein", "compound" ]
NADA is a compound, cytochrome P450 is a protein	DS.d1295_task1	Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please typing these entity words according to sentence: NADA, cytochrome P450 Options: compound, protein	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.	[ "To", "investigate", "the", "metabolism", "of", "NADA", "through", "the", "cytochrome", "P450", "(", "CYP450", ")", "metabolic", "pathway", ",", "we", "studied", "the", "in", "vitro", "rat", "liver", "microsomal", "production", "of", "hydroxylated", "metabolites", "and", "their", "activity", "at", "recombinant", "human", "TRPV(1", ")", "receptors", "." ]	[ "protein", "compound" ]
NADA, cytochrome P450	DS.d1295_task2	Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.	[ "To", "investigate", "the", "metabolism", "of", "NADA", "through", "the", "cytochrome", "P450", "(", "CYP450", ")", "metabolic", "pathway", ",", "we", "studied", "the", "in", "vitro", "rat", "liver", "microsomal", "production", "of", "hydroxylated", "metabolites", "and", "their", "activity", "at", "recombinant", "human", "TRPV(1", ")", "receptors", "." ]	[ "protein", "compound" ]
ambulanter Chirurgie is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Maennern is an umlsterm, Maenner is an umlsterm, Aengstlichkeit is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerzempfindung is an umlsterm, Atemdepression is an umlsterm, Sauerstoffsaettigung is an umlsterm, Blutdruck is an umlsterm, Konzentrationstest is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm, Sicherheit is an umlsterm, Patienten is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm	DerAnaesthesist.60450826.ger.abstr_task0	Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .	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ambulanter Chirurgie is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Maennern is an umlsterm, Maenner is an umlsterm, Aengstlichkeit is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerzempfindung is an umlsterm, Atemdepression is an umlsterm, Sauerstoffsaettigung is an umlsterm, Blutdruck is an umlsterm, Konzentrationstest is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm, Sicherheit is an umlsterm, Patienten is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm	DerAnaesthesist.60450826.ger.abstr_task1	Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please typing these entity words according to sentence: ambulanter Chirurgie, Praemedikation, Midazolam, Maennern, Maenner, Aengstlichkeit, Merkfaehigkeit, Schmerzempfindung, Atemdepression, Sauerstoffsaettigung, Blutdruck, Konzentrationstest, Praemedikation, Praemedikation, Praemedikation, Midazolam, Patienten, Sicherheit, Patienten, Midazolam, Patienten Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .	[ "Insbesondere", "unter", "dem", "Aspekt", "ambulanter", "Chirurgie", "sollte", "ueberprueft", "werden", ",", "inwieweit", "eine", "orale", "Praemedikation", "mit", "3,75", "mg", "Midazolam", "bei", "Maennern", "ueber", "60", "Jahre", "perioperativ", "kognitive", "und", "physiologische", "Funktionen", "veraendert", ".", "In", "einer", "randomisierten", ",", "doppelt", "maskierten", "und", "plazebokontrollierten", "Studie", "wurden", "insgesamt", "47", "Maenner", "(", "Alter", ">", "60", "Jahre", ",", "Gewicht", "50", "bis", "90", "kg", ")", "untersucht", ",", "bei", "denen", "ein", "intraokularer", "Eingriff", "in", "Retrobulbaeranaesthesie", "durchgefuehrt", "wurde", ".", "Folgende", "Messgroessen", "wurden", "bestimmt", "Sedierung", "(", ":", "Rangskalierung", "mit", "5", "Stufen", "Aengstlichkeit", "(", "visuelle", "Analogskala", ")", ",", "Merkfaehigkeit", "(", ")", ",", "Zahlennachsprechen", "Konzentrationsfaehigkeit", "(", ")", ",", "Revisionstest", "nach", "Stender", "u.", "Marschner", "Langzeitgedaechtnis", "(", "Wortmerktest", ")", "und", "Schmerzempfindung", "(", ")", ",", "visuelle", "Analogskala", ")", ".", "Zur", "Erfassung", "einer", "intraoperativen", "Atemdepression", "wurden", "intraoperativ", "pulsoxymetrische", "Sauerstoffsaettigung", "und", "endexspiratorischer", "pCO2", "(", "nasal", ")", "kontrolliert", ".", "Eine", "halbe", "Stunde", "nach", "Midazolam", "-", "Praemedikation", "war", "die", "Sedierung", "signifikant", "staerker", "(", "p", "0,01", ")", "ausgepraegt", "und", "der", "systolische", "Blutdruck", "signifikant", "niedriger", "(", "p", "0,05", ")", "als", "in", "der", "Plazebogruppe", ".", "Bei", "den", "kognitiven", "Funktionstests", "fanden", "sich", "nur", "1/2", "h", "nach", "Midazolam", "-", "Praemedikation", "signifikante", "Unterschiede", "im", "Konzentrationstest", "nach", "Stender", "u.", "Marschner", "(", "p", "0,05", ")", ".", "2", "h", "nach", "Operation", "(", "293", "+", "/-", "41", "min", "nach", "Praemedikation", ")", "zeigten", "sich", "keine", "Veraenderungen", "der", "physiologischen", "und", "kognitiven", "Funktionen", ".", "Da", "kognitive", "und", "physiologische", "Funktionen", "unmittelbar", "nach", "der", "Praemedikation", "geringfuegig", "eingeschraenkt", "sind", ",", "postoperativ", "aber", "keine", "Veraenderungen", "dieser", "Funktionen", "nachzuweisen", "sind", ",", "erscheint", "eine", "orale", "Praemedikation", "mit", "durchschnittlich", "0,049", "+", "/-", "0,006", "mg", "/", "kg", "Midazolam", "fuer", "ambulante", "Eingriffe", "bei", "aelteren", "Patienten", "geeignet", "zu", "sein", ".", "Zugunsten", "der", "Sicherheit", "des", "Patienten", "ist", "bei", "routinemaessigem", "Einsatz", "von", "3,75", "mg", "Midazolam", "die", "Praemedikationsdosis", "bei", "einem", "Teil", "der", "Patienten", "vermutlich", "zu", "niedrig", "." ]	[ "umlsterm" ]
ambulanter Chirurgie, Praemedikation, Midazolam, Maennern, Maenner, Aengstlichkeit, Merkfaehigkeit, Schmerzempfindung, Atemdepression, Sauerstoffsaettigung, Blutdruck, Konzentrationstest, Praemedikation, Praemedikation, Praemedikation, Midazolam, Patienten, Sicherheit, Patienten, Midazolam, Patienten	DerAnaesthesist.60450826.ger.abstr_task2	Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .	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Gestationsalter is an umlsterm, Bupivacain is an umlsterm, Leistenhernienoperation is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Adrenalin is an umlsterm, Zeit is an umlsterm, Injektion is an umlsterm, Beine is an umlsterm, EKG is an umlsterm, Blutdruckwerte is an umlsterm, Lumbalpunktion is an umlsterm, Injektion is an umlsterm, Blutdruckwerten is an umlsterm	DerAnaesthesist.40430026.ger.abstr_task0	Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .	[ "Bei", "10", "ehemaligen", "Fruehgeborenen", "mit", "einem", "Gestationsalter", "zwischen", "38", "und", "48", "Wochen", "am", "Operationstag", "und", "einem", "Gewicht", "zwischen", "2,10", "und", "3,22", "kg", ",", "die", "postpartal", "respiratorische", "Adaptationsstoerungen", "aufwiesen", ",", "wurde", "nach", "elterlichem", "Einverstaendnis", "eine", "Spinalanaesthesie", "mit", "0,6", "ml", "Bupivacain", "0,5", "%", "fuer", "eine", "Leistenhernienoperation", "durchgefuehrt", ".", "Jeweils", "5", "Patienten", "erhielten", "Bupivacain", "ohne", "Adrenalinzusatz", "(", "Gruppe", "I", ")", "bzw", ".", "mit", "Adrenalin", "1", "200", "000=5", "µg", "/", "ml", "(", ":", "Gruppe", "II", ")", ".", "Die", "Wirkdauer", "wurde", "definiert", "als", "Zeit", "von", "der", "Injektion", "bis", "zur", "ersten", "Bewegung", "der", "Beine", ":", "Die", "ueber", "das", "EKG", "registrierte", "Herzfrequenz", "und", "die", "oszillometrisch", "gemessenen", "Blutdruckwerte", "wurden", "vor", "Lagerung", "zur", "Lumbalpunktion", "sowie", "2", ",", "5", ",", "10", "und", "20", "min", "nach", "der", "Injektion", "des", "Lokalanaesthetikums", "erhoben", ".", "Die", "Wirkdauer", "einer", "Spinalanaesthesie", "war", "im", "Median", "in", "der", "Gruppe", "II", "mit", "95", "min", "(", "60", "-", "120", ")", "signifikant", "laenger", "als", "in", "der", "Gruppe", "I", "mit", "50", "min", "(", "37", "-", "85", ")", ".", "Keine", "signifikanten", "Unterschiede", "zeigten", "sich", "bei", "Herzfrequenz", "und", "Blutdruckwerten", "-", "weder", "zwischen", "den", "Gruppen", "noch", "im", "zeitlichen", "Verlauf", "einer", "Gruppe", "." ]	[ "umlsterm" ]
Gestationsalter is an umlsterm, Bupivacain is an umlsterm, Leistenhernienoperation is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Adrenalin is an umlsterm, Zeit is an umlsterm, Injektion is an umlsterm, Beine is an umlsterm, EKG is an umlsterm, Blutdruckwerte is an umlsterm, Lumbalpunktion is an umlsterm, Injektion is an umlsterm, Blutdruckwerten is an umlsterm	DerAnaesthesist.40430026.ger.abstr_task1	Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please typing these entity words according to sentence: Gestationsalter, Bupivacain, Leistenhernienoperation, Patienten, Bupivacain, Adrenalin, Zeit, Injektion, Beine, EKG, Blutdruckwerte, Lumbalpunktion, Injektion, Blutdruckwerten Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .	[ "Bei", "10", "ehemaligen", "Fruehgeborenen", "mit", "einem", "Gestationsalter", "zwischen", "38", "und", "48", "Wochen", "am", "Operationstag", "und", "einem", "Gewicht", "zwischen", "2,10", "und", "3,22", "kg", ",", "die", "postpartal", "respiratorische", "Adaptationsstoerungen", "aufwiesen", ",", "wurde", "nach", "elterlichem", "Einverstaendnis", "eine", "Spinalanaesthesie", "mit", "0,6", "ml", "Bupivacain", "0,5", "%", "fuer", "eine", "Leistenhernienoperation", "durchgefuehrt", ".", "Jeweils", "5", "Patienten", "erhielten", "Bupivacain", "ohne", "Adrenalinzusatz", "(", "Gruppe", "I", ")", "bzw", ".", "mit", "Adrenalin", "1", "200", "000=5", "µg", "/", "ml", "(", ":", "Gruppe", "II", ")", ".", "Die", "Wirkdauer", "wurde", "definiert", "als", "Zeit", "von", "der", "Injektion", "bis", "zur", "ersten", "Bewegung", "der", "Beine", ":", "Die", "ueber", "das", "EKG", "registrierte", "Herzfrequenz", "und", "die", "oszillometrisch", "gemessenen", "Blutdruckwerte", "wurden", "vor", "Lagerung", "zur", "Lumbalpunktion", "sowie", "2", ",", "5", ",", "10", "und", "20", "min", "nach", "der", "Injektion", "des", "Lokalanaesthetikums", "erhoben", ".", "Die", "Wirkdauer", "einer", "Spinalanaesthesie", "war", "im", "Median", "in", "der", "Gruppe", "II", "mit", "95", "min", "(", "60", "-", "120", ")", "signifikant", "laenger", "als", "in", "der", "Gruppe", "I", "mit", "50", "min", "(", "37", "-", "85", ")", ".", "Keine", "signifikanten", "Unterschiede", "zeigten", "sich", "bei", "Herzfrequenz", "und", "Blutdruckwerten", "-", "weder", "zwischen", "den", "Gruppen", "noch", "im", "zeitlichen", "Verlauf", "einer", "Gruppe", "." ]	[ "umlsterm" ]
Gestationsalter, Bupivacain, Leistenhernienoperation, Patienten, Bupivacain, Adrenalin, Zeit, Injektion, Beine, EKG, Blutdruckwerte, Lumbalpunktion, Injektion, Blutdruckwerten	DerAnaesthesist.40430026.ger.abstr_task2	Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .	[ "Bei", "10", "ehemaligen", "Fruehgeborenen", "mit", "einem", "Gestationsalter", "zwischen", "38", "und", "48", "Wochen", "am", "Operationstag", "und", "einem", "Gewicht", "zwischen", "2,10", "und", "3,22", "kg", ",", "die", "postpartal", "respiratorische", "Adaptationsstoerungen", "aufwiesen", ",", "wurde", "nach", "elterlichem", "Einverstaendnis", "eine", "Spinalanaesthesie", "mit", "0,6", "ml", "Bupivacain", "0,5", "%", "fuer", "eine", "Leistenhernienoperation", "durchgefuehrt", ".", "Jeweils", "5", "Patienten", "erhielten", "Bupivacain", "ohne", "Adrenalinzusatz", "(", "Gruppe", "I", ")", "bzw", ".", "mit", "Adrenalin", "1", "200", "000=5", "µg", "/", "ml", "(", ":", "Gruppe", "II", ")", ".", "Die", "Wirkdauer", "wurde", "definiert", "als", "Zeit", "von", "der", "Injektion", "bis", "zur", "ersten", "Bewegung", "der", "Beine", ":", "Die", "ueber", "das", "EKG", "registrierte", "Herzfrequenz", "und", "die", "oszillometrisch", "gemessenen", "Blutdruckwerte", "wurden", "vor", "Lagerung", "zur", "Lumbalpunktion", "sowie", "2", ",", "5", ",", "10", "und", "20", "min", "nach", "der", "Injektion", "des", "Lokalanaesthetikums", "erhoben", ".", "Die", "Wirkdauer", "einer", "Spinalanaesthesie", "war", "im", "Median", "in", "der", "Gruppe", "II", "mit", "95", "min", "(", "60", "-", "120", ")", "signifikant", "laenger", "als", "in", "der", "Gruppe", "I", "mit", "50", "min", "(", "37", "-", "85", ")", ".", "Keine", "signifikanten", "Unterschiede", "zeigten", "sich", "bei", "Herzfrequenz", "und", "Blutdruckwerten", "-", "weder", "zwischen", "den", "Gruppen", "noch", "im", "zeitlichen", "Verlauf", "einer", "Gruppe", "." ]	[ "umlsterm" ]
anticuerpos antitransglutaminasa is a PROTEINAS, gluten is a UNCLEAR, anticuerpos anticardiolipina is a PROTEINAS, IgG is a PROTEINAS, anticardiolipina is a PROTEINAS, IgM is a PROTEINAS, ácido acetilsalicílico is a NORMALIZABLES	291_task0	Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: UNCLEAR, NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-UNCLEAR", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.	[ "Paciente", "mujer", ",", "edad", "26", "años", ",", "diagnosticada", "de", "enfermedad", "celiaca", "con", "anticuerpos", "antitransglutaminasa", "73", "U", "(", "valor", "normal", "hasta", "10", ")", "y", "biopsia", "duodenal", "con", "enteropatía", "con", "atrofia", "vellocitaria", "severa", "(", "grado", "III", ")", ".", "Presentó", "buena", "evolución", "con", "dieta", "libre", "de", "gluten", ",", "desapareciendo", "diarrea", "y", "mejorando", "estado", "nutricional", ".", "Seis", "meses", "después", "la", "paciente", "queda", "embarazada", ",", "presentando", "muerte", "fetal", "a", "las", "36", "semanas", ".", "Al", "año", "siguiente", "presenta", "nuevo", "embarazo", ".", "Se", "determinan", "anticuerpos", "anticardiolipina", "IgG", ":", "20", "GPL", "U", "/", "ml", "(", "v.n", ".", "<", "11", ")", "y", "anticardiolipina", "IgM", ":", "9", "MPL", "U", "/", "ml", "(", "v.n", ".", "<", "10", ")", ".", "El", "estudio", "hematológico", "no", "evidenció", "otras", "alteraciones", "protrombóticas", ".", "Se", "la", "medica", "con", "ácido", "acetilsalicílico", "a", "dosis", "de", "200", "mg", "/", "día", "presentando", "embarazo", "y", "nacimiento", "por", "cesárea", "normales", ".", "\n\n" ]	[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]
anticuerpos antitransglutaminasa is a PROTEINAS, gluten is a UNCLEAR, anticuerpos anticardiolipina is a PROTEINAS, IgG is a PROTEINAS, anticardiolipina is a PROTEINAS, IgM is a PROTEINAS, ácido acetilsalicílico is a NORMALIZABLES	291_task1	Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please typing these entity words according to sentence: anticuerpos antitransglutaminasa, gluten, anticuerpos anticardiolipina, IgG, anticardiolipina, IgM, ácido acetilsalicílico Options: UNCLEAR, NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-UNCLEAR", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.	[ "Paciente", "mujer", ",", "edad", "26", "años", ",", "diagnosticada", "de", "enfermedad", "celiaca", "con", "anticuerpos", "antitransglutaminasa", "73", "U", "(", "valor", "normal", "hasta", "10", ")", "y", "biopsia", "duodenal", "con", "enteropatía", "con", "atrofia", "vellocitaria", "severa", "(", "grado", "III", ")", ".", "Presentó", "buena", "evolución", "con", "dieta", "libre", "de", "gluten", ",", "desapareciendo", "diarrea", "y", "mejorando", "estado", "nutricional", ".", "Seis", "meses", "después", "la", "paciente", "queda", "embarazada", ",", "presentando", "muerte", "fetal", "a", "las", "36", "semanas", ".", "Al", "año", "siguiente", "presenta", "nuevo", "embarazo", ".", "Se", "determinan", "anticuerpos", "anticardiolipina", "IgG", ":", "20", "GPL", "U", "/", "ml", "(", "v.n", ".", "<", "11", ")", "y", "anticardiolipina", "IgM", ":", "9", "MPL", "U", "/", "ml", "(", "v.n", ".", "<", "10", ")", ".", "El", "estudio", "hematológico", "no", "evidenció", "otras", "alteraciones", "protrombóticas", ".", "Se", "la", "medica", "con", "ácido", "acetilsalicílico", "a", "dosis", "de", "200", "mg", "/", "día", "presentando", "embarazo", "y", "nacimiento", "por", "cesárea", "normales", ".", "\n\n" ]	[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]
anticuerpos antitransglutaminasa, gluten, anticuerpos anticardiolipina, IgG, anticardiolipina, IgM, ácido acetilsalicílico	291_task2	Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-UNCLEAR", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.	[ "Paciente", "mujer", ",", "edad", "26", "años", ",", "diagnosticada", "de", "enfermedad", "celiaca", "con", "anticuerpos", "antitransglutaminasa", "73", "U", "(", "valor", "normal", "hasta", "10", ")", "y", "biopsia", "duodenal", "con", "enteropatía", "con", "atrofia", "vellocitaria", "severa", "(", "grado", "III", ")", ".", "Presentó", "buena", "evolución", "con", "dieta", "libre", "de", "gluten", ",", "desapareciendo", "diarrea", "y", "mejorando", "estado", "nutricional", ".", "Seis", "meses", "después", "la", "paciente", "queda", "embarazada", ",", "presentando", "muerte", "fetal", "a", "las", "36", "semanas", ".", "Al", "año", "siguiente", "presenta", "nuevo", "embarazo", ".", "Se", "determinan", "anticuerpos", "anticardiolipina", "IgG", ":", "20", "GPL", "U", "/", "ml", "(", "v.n", ".", "<", "11", ")", "y", "anticardiolipina", "IgM", ":", "9", "MPL", "U", "/", "ml", "(", "v.n", ".", "<", "10", ")", ".", "El", "estudio", "hematológico", "no", "evidenció", "otras", "alteraciones", "protrombóticas", ".", "Se", "la", "medica", "con", "ácido", "acetilsalicílico", "a", "dosis", "de", "200", "mg", "/", "día", "presentando", "embarazo", "y", "nacimiento", "por", "cesárea", "normales", ".", "\n\n" ]	[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]
Magnetic resonance imaging is a Intervention_Physical, otospongiosis : is a Participant_Condition, magnetic resonance imaging ( MRI ) is a Intervention_Physical, Twenty - six is a Participant_Sample-size, n = 42 ears is a Participant_Sample-size, otosclerosis is a Participant_Condition, computed tomography is a Intervention_Physical, placebo is a Intervention_Control, sodium alendronate is a Intervention_Pharmacological, sodium fluoride is a Intervention_Pharmacological	70571_task0	Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Intervention_Control, Participant_Condition, Participant_Sample-size	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .	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Magnetic resonance imaging is a Intervention_Physical, otospongiosis : is a Participant_Condition, magnetic resonance imaging ( MRI ) is a Intervention_Physical, Twenty - six is a Participant_Sample-size, n = 42 ears is a Participant_Sample-size, otosclerosis is a Participant_Condition, computed tomography is a Intervention_Physical, placebo is a Intervention_Control, sodium alendronate is a Intervention_Pharmacological, sodium fluoride is a Intervention_Pharmacological	70571_task1	Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please typing these entity words according to sentence: Magnetic resonance imaging, otospongiosis :, magnetic resonance imaging ( MRI ), Twenty - six, n = 42 ears, otosclerosis, computed tomography, placebo, sodium alendronate, sodium fluoride Options: Intervention_Pharmacological, Intervention_Physical, Intervention_Control, Participant_Condition, Participant_Sample-size	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .	[ "Magnetic", "resonance", "imaging", "in", "the", "evaluation", "of", "clinical", "treatment", "of", "otospongiosis", ":", "a", "pilot", "study", ".", "OBJECTIVES", "To", "evaluate", "the", "applicability", "of", "magnetic", "resonance", "imaging", "(", "MRI", ")", "as", "a", "method", "for", "monitoring", "the", "activity", "of", "otospongiotic", "lesions", "before", "and", "after", "clinical", "treatment", ".", "STUDY", "DESIGN", "Prospective", ",", "randomized", ",", "controlled", ",", "double", "-", "blind", "study", ".", "SETTING", "One", "single", "tertiary", "care", "institution", "in", "a", "large", ",", "cosmopolitan", "city", ".", "METHODS", "Twenty", "-", "six", "patients", "(", "n", "=", "42", "ears", ")", "with", "clinical", ",", "audiometric", ",", "and", "tomographic", "diagnosis", "of", "otosclerosis", "were", "enrolled", ".", "If", "computed", "tomography", "(", "CT", ")", "demonstrated", "active", "lesions", ",", "these", "patients", "underwent", "MRI", "to", "detect", "otospongiotic", "foci", ",", "seen", "as", "areas", "of", "gadolinium", "enhancement", ".", "Patients", "were", "divided", "into", "3", "groups", "and", "received", "treatment", "with", "placebo", ",", "sodium", "alendronate", ",", "or", "sodium", "fluoride", "for", "6", "months", ".", "After", "this", "period", ",", "clinical", "and", "audiometric", "evaluations", "and", "a", "second", "MRI", "were", "performed", ".", "Each", "MRI", "was", "evaluated", "by", "both", "a", "neuroradiologist", "and", "an", "otolaryngologist", "in", "a", "subjective", "(", "visual", ")", "and", "objective", "(", "using", "specific", "eFilm", "Workstation", "software", ")", "manner", ".", "RESULTS", "Otospongiosis", "was", "most", "predominantly", "identified", "in", "the", "region", "anterior", "to", "the", "oval", "window", ",", "and", "this", "site", "was", "reliable", "for", "comparing", "pre-", "and", "posttreatment", "scans", ".", "The", "patients", "in", "the", "alendronate", "and", "sodium", "fluoride", "groups", "had", "MRI", "findings", "that", "suggested", "a", "decrease", "in", "activity", "of", "otospongiotic", "lesions", ",", "more", "relevant", "in", "the", "alendronate", "group", ".", "These", "findings", "were", "statistically", "significant", "for", "both", "subjective", "and", "objective", "MRI", "evaluations", ".", "CONCLUSIONS", "MRI", "shows", "higher", "sensitivity", "than", "clinical", "or", "audiometric", "assessment", "for", "detecting", "reduction", "in", "activity", "of", "otospongiosis", ".", "The", "objective", "MRI", "evaluation", "based", "on", "software", "analysis", "was", "the", "most", "accurate", "method", "of", "monitoring", "clinical", "treatment", "response", "in", "otospongiosis", "." ]	[ "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size", "Intervention_Control" ]
Magnetic resonance imaging, otospongiosis :, magnetic resonance imaging ( MRI ), Twenty - six, n = 42 ears, otosclerosis, computed tomography, placebo, sodium alendronate, sodium fluoride	70571_task2	Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .	[ "Magnetic", "resonance", "imaging", "in", "the", "evaluation", "of", "clinical", "treatment", "of", "otospongiosis", ":", "a", "pilot", "study", ".", "OBJECTIVES", "To", "evaluate", "the", "applicability", "of", "magnetic", "resonance", "imaging", "(", "MRI", ")", "as", "a", "method", "for", "monitoring", "the", "activity", "of", "otospongiotic", "lesions", "before", "and", "after", "clinical", "treatment", ".", "STUDY", "DESIGN", "Prospective", ",", "randomized", ",", "controlled", ",", "double", "-", "blind", "study", ".", "SETTING", "One", "single", "tertiary", "care", "institution", "in", "a", "large", ",", "cosmopolitan", "city", ".", "METHODS", "Twenty", "-", "six", "patients", "(", "n", "=", "42", "ears", ")", "with", "clinical", ",", "audiometric", ",", "and", "tomographic", "diagnosis", "of", "otosclerosis", "were", "enrolled", ".", "If", "computed", "tomography", "(", "CT", ")", "demonstrated", "active", "lesions", ",", "these", "patients", "underwent", "MRI", "to", "detect", "otospongiotic", "foci", ",", "seen", "as", "areas", "of", "gadolinium", "enhancement", ".", "Patients", "were", "divided", "into", "3", "groups", "and", "received", "treatment", "with", "placebo", ",", "sodium", "alendronate", ",", "or", "sodium", "fluoride", "for", "6", "months", ".", "After", "this", "period", ",", "clinical", "and", "audiometric", "evaluations", "and", "a", "second", "MRI", "were", "performed", ".", "Each", "MRI", "was", "evaluated", "by", "both", "a", "neuroradiologist", "and", "an", "otolaryngologist", "in", "a", "subjective", "(", "visual", ")", "and", "objective", "(", "using", "specific", "eFilm", "Workstation", "software", ")", "manner", ".", "RESULTS", "Otospongiosis", "was", "most", "predominantly", "identified", "in", "the", "region", "anterior", "to", "the", "oval", "window", ",", "and", "this", "site", "was", "reliable", "for", "comparing", "pre-", "and", "posttreatment", "scans", ".", "The", "patients", "in", "the", "alendronate", "and", "sodium", "fluoride", "groups", "had", "MRI", "findings", "that", "suggested", "a", "decrease", "in", "activity", "of", "otospongiotic", "lesions", ",", "more", "relevant", "in", "the", "alendronate", "group", ".", "These", "findings", "were", "statistically", "significant", "for", "both", "subjective", "and", "objective", "MRI", "evaluations", ".", "CONCLUSIONS", "MRI", "shows", "higher", "sensitivity", "than", "clinical", "or", "audiometric", "assessment", "for", "detecting", "reduction", "in", "activity", "of", "otospongiosis", ".", "The", "objective", "MRI", "evaluation", "based", "on", "software", "analysis", "was", "the", "most", "accurate", "method", "of", "monitoring", "clinical", "treatment", "response", "in", "otospongiosis", "." ]	[ "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size", "Intervention_Control" ]
LYSP100-associated nuclear domains is a cell_component, LANDs is a cell_component, subnuclear structures is a cell_component, PML nuclear bodies is a cell_component	25253_task0	Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_component	[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]	LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.	[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]	[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]
LYSP100-associated nuclear domains is a cell_component, LANDs is a cell_component, subnuclear structures is a cell_component, PML nuclear bodies is a cell_component	25253_task1	Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please typing these entity words according to sentence: LYSP100-associated nuclear domains, LANDs, subnuclear structures, PML nuclear bodies Options: cell_component	[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]	LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.	[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]	[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]
LYSP100-associated nuclear domains, LANDs, subnuclear structures, PML nuclear bodies	25253_task2	Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please extract entity words from the input sentence	[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]	LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.	[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]	[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]

tazarotene

12942109_task2

Sentence: A phase 1 study of tazarotene in adults with advanced cancer. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O" ]

A phase 1 study of tazarotene in adults with advanced cancer.

[ "A", "phase", "1", "study", "of", "tazarotene", "in", "adults", "with", "advanced", "cancer", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Chloe is a NOMBRE_SUJETO_ASISTENCIA, Villanueva Marin is a NOMBRE_SUJETO_ASISTENCIA, 3785612 is a ID_SUJETO_ASISTENCIA, Calle Fernando Higueras , 27 is a CALLE, Las Palmas is a TERRITORIO, 35016 is a TERRITORIO, 27/03/2016 is a FECHAS, España is a PAIS, 8 dias is a EDAD_SUJETO_ASISTENCIA, 04/04/2016 is a FECHAS, 4375656 is a ID_CONTACTO_ASISTENCIAL, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, 35 35 20015 is a ID_TITULACION_PERSONAL_SANITARIO, Lactante is a ID_SUJETO_ASISTENCIA, ocho días is a EDAD_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, primera hija is a ID_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, dos días is a EDAD_SUJETO_ASISTENCIA, ocho meses is a EDAD_SUJETO_ASISTENCIA, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, Complejo Hospitalario Universitario Insular - Materno Infantil is a HOSPITAL, Avda . Marítima del Sur , sn is a CALLE, 35016 is a TERRITORIO, Las Palmas de Gran Canaria is a TERRITORIO, Islas Canarias is a TERRITORIO, España is a PAIS, aidacost@hotmail.com is a CORREO_ELECTRONICO

467_task0

Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com

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[ "HOSPITAL", "CALLE", "TERRITORIO", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "NOMBRE_SUJETO_ASISTENCIA", "ID_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "EDAD_SUJETO_ASISTENCIA", "FECHAS", "ID_CONTACTO_ASISTENCIAL", "PAIS", "FAMILIARES_SUJETO_ASISTENCIA", "SEXO_SUJETO_ASISTENCIA" ]

Chloe is a NOMBRE_SUJETO_ASISTENCIA, Villanueva Marin is a NOMBRE_SUJETO_ASISTENCIA, 3785612 is a ID_SUJETO_ASISTENCIA, Calle Fernando Higueras , 27 is a CALLE, Las Palmas is a TERRITORIO, 35016 is a TERRITORIO, 27/03/2016 is a FECHAS, España is a PAIS, 8 dias is a EDAD_SUJETO_ASISTENCIA, 04/04/2016 is a FECHAS, 4375656 is a ID_CONTACTO_ASISTENCIAL, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, 35 35 20015 is a ID_TITULACION_PERSONAL_SANITARIO, Lactante is a ID_SUJETO_ASISTENCIA, ocho días is a EDAD_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, primera hija is a ID_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, dos días is a EDAD_SUJETO_ASISTENCIA, ocho meses is a EDAD_SUJETO_ASISTENCIA, Aída Acosta Arencibia is a NOMBRE_PERSONAL_SANITARIO, Complejo Hospitalario Universitario Insular - Materno Infantil is a HOSPITAL, Avda . Marítima del Sur , sn is a CALLE, 35016 is a TERRITORIO, Las Palmas de Gran Canaria is a TERRITORIO, Islas Canarias is a TERRITORIO, España is a PAIS, aidacost@hotmail.com is a CORREO_ELECTRONICO

467_task1

Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please typing these entity words according to sentence: Chloe, Villanueva Marin, 3785612, Calle Fernando Higueras , 27, Las Palmas, 35016, 27/03/2016, España, 8 dias, 04/04/2016, 4375656, Aída Acosta Arencibia, 35 35 20015, Lactante, ocho días, padres, primera hija, padres, dos días, ocho meses, Aída Acosta Arencibia, Complejo Hospitalario Universitario Insular - Materno Infantil, Avda . Marítima del Sur , sn, 35016, Las Palmas de Gran Canaria, Islas Canarias, España, aidacost@hotmail.com Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, HOSPITAL, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, ID_CONTACTO_ASISTENCIAL, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

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Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com

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[ "HOSPITAL", "CALLE", "TERRITORIO", "NOMBRE_PERSONAL_SANITARIO", "CORREO_ELECTRONICO", "NOMBRE_SUJETO_ASISTENCIA", "ID_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "EDAD_SUJETO_ASISTENCIA", "FECHAS", "ID_CONTACTO_ASISTENCIAL", "PAIS", "FAMILIARES_SUJETO_ASISTENCIA", "SEXO_SUJETO_ASISTENCIA" ]

Chloe, Villanueva Marin, 3785612, Calle Fernando Higueras , 27, Las Palmas, 35016, 27/03/2016, España, 8 dias, 04/04/2016, 4375656, Aída Acosta Arencibia, 35 35 20015, Lactante, ocho días, padres, primera hija, padres, dos días, ocho meses, Aída Acosta Arencibia, Complejo Hospitalario Universitario Insular - Materno Infantil, Avda . Marítima del Sur , sn, 35016, Las Palmas de Gran Canaria, Islas Canarias, España, aidacost@hotmail.com

467_task2

Sentence: Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com Instructions: please extract entity words from the input sentence

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Datos del paciente. Nombre: Chloe. Apellidos: Villanueva Marin. NHC: 3785612. Domicilio: Calle Fernando Higueras, 27. Localidad/ Provincia: Las Palmas. CP: 35016. Datos asistenciales. Fecha de nacimiento: 27/03/2016. País: España. Edad: 8 dias Sexo: M. Fecha de Ingreso: 04/04/2016. Servicio: Cirugía Plástica . Episodio: 4375656. Médico:Aída Acosta Arencibia NºCol: 35 35 20015. Historia Actual: Lactante de ocho días cuyos padres consultan por ombligo poco cicatrizado. Como antecedentes personales, se trata de la primera hija de padres sanos. Nacida a las 39 semanas de gestación por parto eutócico; Apgar 9/10, peso 2830 gramos. No refieren antecedentes de interés, ni aportan el informe hospitalario. En la exploración se aprecia una implantación amplia del cordón umbilical, que tiene aspecto mucoso, y un pequeño desgarro en la base del mismo, sin signos de infección local. El resto de la exploración física es normal. No refiere ninguna manifestación clínica acompañante. Se aplica nitrato de plata y se cita para su control en 48 horas. En la visita de control aportan el informe de alta tras el nacimiento. Refleja que el cordón umbilical presentaba un quiste, diagnosticado en la ecografía prenatal del segundo trimestre y descrito como quiste de gelatina de Wharton de 49 x 39 mm. Al nacimiento fue valorada por un cirujano, que colocó una pinza proximal al quiste, que fue resecado. A los dos días de vida realizan una ecografía abdominal que fue normal. Durante el ingreso permaneció asintomática y dan el alta con normalidad clínica, excepto por un pequeño desgarro en base del cordón, que no presenta complicaciones. En la visita de control ambulatorio se observa una salida abundante de líquido claro del centro del ombligo, sin signos de infección. Se deriva para valoración por cirugía pediátrica. El cirujano liga el cordón umbilical, que está casi desprendido y con aspecto húmedo. Se comprueba la existencia de un trayecto fistuloso. Una nueva ecografía abdominal pone de manifiesto una estructura tubular tortuosa que comunica con la pared vesical superior y se diagnóstica de persistencia del uraco (tipo uraco permeable) y se decide observación y revaloración posterior. A los ocho meses de vida se ha producido el cierre espontáneo, y en los controles posteriores se evidencia la ausencia de la permeabilidad del uraco. Remitido por: Dra. Aída Acosta Arencibia Servicio de Cirugía Plástica Complejo Hospitalario Universitario Insular-Materno Infantil Avda. Marítima del Sur, sn. 35016 Las Palmas de Gran Canaria Islas Canarias. España e-mail: aidacost@hotmail.com

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3 -15 years is a Value, old is a Person, Clinical symptoms suggestive of is a Mood, pharyngitis is a Condition, MC Isaac score is a Measurement, =3 is a Value, Rapid - antigen detection test is a Measurement, RADT is a Measurement, positive is a Value, GAS- is a Qualifier

NCT03264911_inc_task0

Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Measurement, Mood

[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form

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[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]

3 -15 years is a Value, old is a Person, Clinical symptoms suggestive of is a Mood, pharyngitis is a Condition, MC Isaac score is a Measurement, =3 is a Value, Rapid - antigen detection test is a Measurement, RADT is a Measurement, positive is a Value, GAS- is a Qualifier

NCT03264911_inc_task1

Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please typing these entity words according to sentence: 3 -15 years, old, Clinical symptoms suggestive of, pharyngitis, MC Isaac score, =3, Rapid - antigen detection test, RADT, positive, GAS- Options: Condition, Qualifier, Value, Person, Measurement, Mood

[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form

[ "3", "-15", "years", "old", "\n", "Clinical", "symptoms", "suggestive", "of", "pharyngitis", "with", "MC", "Isaac", "score", "=3", "\n", "Rapid", "-", "antigen", "detection", "test", "(", "RADT", ")", "positive", "for", "GAS-", "\n", "Signed", "informed", "parental", "/", "patient", "consent", "form", "\n" ]

[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]

3 -15 years, old, Clinical symptoms suggestive of, pharyngitis, MC Isaac score, =3, Rapid - antigen detection test, RADT, positive, GAS-

NCT03264911_inc_task2

Sentence: 3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form Instructions: please extract entity words from the input sentence

[ "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "I-Mood", "I-Mood", "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Value", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

3 -15 years old Clinical symptoms suggestive of pharyngitis with MC Isaac score =3 Rapid-antigen detection test (RADT) positive for GAS- Signed informed parental/patient consent form

[ "3", "-15", "years", "old", "\n", "Clinical", "symptoms", "suggestive", "of", "pharyngitis", "with", "MC", "Isaac", "score", "=3", "\n", "Rapid", "-", "antigen", "detection", "test", "(", "RADT", ")", "positive", "for", "GAS-", "\n", "Signed", "informed", "parental", "/", "patient", "consent", "form", "\n" ]

[ "Mood", "Measurement", "Value", "Condition", "Qualifier", "Person" ]

Stent is an umlsterm, implantation is an umlsterm, aneurysms is an umlsterm, postmortem examinations is an umlsterm, Measurements is an umlsterm, criteria is an umlsterm, necks is an umlsterm, aneurysms is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, neck is an umlsterm, necks is an umlsterm, stent is an umlsterm, morphological is an umlsterm, neck is an umlsterm, Tube - Stent is an umlsterm, neck is an umlsterm, stent is an umlsterm, aneurysms is an umlsterm, stent is an umlsterm, implantation is an umlsterm, ulcerations is an umlsterm, secondary is an umlsterm, thrombi is an umlsterm, para - aneurysmal is an umlsterm, findings is an umlsterm, transport is an umlsterm, prosthesis is an umlsterm, implantation is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, aorta is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task0

Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .

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[ "umlsterm" ]

Stent is an umlsterm, implantation is an umlsterm, aneurysms is an umlsterm, postmortem examinations is an umlsterm, Measurements is an umlsterm, criteria is an umlsterm, necks is an umlsterm, aneurysms is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, neck is an umlsterm, necks is an umlsterm, stent is an umlsterm, morphological is an umlsterm, neck is an umlsterm, Tube - Stent is an umlsterm, neck is an umlsterm, stent is an umlsterm, aneurysms is an umlsterm, stent is an umlsterm, implantation is an umlsterm, ulcerations is an umlsterm, secondary is an umlsterm, thrombi is an umlsterm, para - aneurysmal is an umlsterm, findings is an umlsterm, transport is an umlsterm, prosthesis is an umlsterm, implantation is an umlsterm, necks is an umlsterm, aneurysm is an umlsterm, aorta is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task1

Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please typing these entity words according to sentence: Stent, implantation, aneurysms, postmortem examinations, Measurements, criteria, necks, aneurysms, necks, aneurysm, neck, necks, stent, morphological, neck, Tube - Stent, neck, stent, aneurysms, stent, implantation, ulcerations, secondary, thrombi, para - aneurysmal, findings, transport, prosthesis, implantation, necks, aneurysm, aorta Options: umlsterm

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In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .

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[ "umlsterm" ]

Stent, implantation, aneurysms, postmortem examinations, Measurements, criteria, necks, aneurysms, necks, aneurysm, neck, necks, stent, morphological, neck, Tube - Stent, neck, stent, aneurysms, stent, implantation, ulcerations, secondary, thrombi, para - aneurysmal, findings, transport, prosthesis, implantation, necks, aneurysm, aorta

ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr_task2

Sentence: In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta . Instructions: please extract entity words from the input sentence

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In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta .

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[ "umlsterm" ]

Angst is an umlsterm, Diagnose is an umlsterm, Aengste is an umlsterm, Aengsten is an umlsterm, Patienten is an umlsterm, depression is an umlsterm, Konzeption is an umlsterm, Therapie is an umlsterm, Depressionen is an umlsterm

DerNervenarzt.80690956.ger.abstr_task0

Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .

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[ "umlsterm" ]

Angst is an umlsterm, Diagnose is an umlsterm, Aengste is an umlsterm, Aengsten is an umlsterm, Patienten is an umlsterm, depression is an umlsterm, Konzeption is an umlsterm, Therapie is an umlsterm, Depressionen is an umlsterm

DerNervenarzt.80690956.ger.abstr_task1

Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please typing these entity words according to sentence: Angst, Diagnose, Aengste, Aengsten, Patienten, depression, Konzeption, Therapie, Depressionen Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .

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[ "umlsterm" ]

Angst, Diagnose, Aengste, Aengsten, Patienten, depression, Konzeption, Therapie, Depressionen

DerNervenarzt.80690956.ger.abstr_task2

Sentence: Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen . Instructions: please extract entity words from the input sentence

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Nach einer Darstellung der Symptomatologie des depressiven Wahns werden die einzelnen Themen , ihre Beziehungen zum depressiven Schulderleben und zur depressiven Angst sowie ihre Abgrenzung eroertert . Schuldwahn Armutswahn und Krankheitswahn , sind einschliesslich ihrer Vorstufen keineswegs seltene Symptome , die fuer die Diagnose Major depressive disorder/endogene Depression/Melancholie beweisend sind . Die Vorstufen , naemlich Verschuldungs- , Verarmungs- und hypochondrische Aengste sind ebenfalls charakteristische Symptome , die sich von den Aengsten der Patienten mit neurotischen Depressionen/Dysthymia mit hoher Trennschaerfe abgrenzen lassen . Delusional depression erwies sich zwar nicht als eine Krankheitseinheit , die Konzeption aber war von heuristischer Bedeutung im Hinblick auf die Therapie . Dem besonderen Schwere- und Auspraegungsgrad dieser Depressionen entsprechen spezielle therapeutische Vorgehensweisen .

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[ "umlsterm" ]

Retinoid is a CHEMICAL

2922761_task0

Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.

[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Retinoid is a CHEMICAL

2922761_task1

Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please typing these entity words according to sentence: Retinoid Options: CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.

[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Retinoid

2922761_task2

Sentence: Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K.

[ "Retinoid", "-", "induced", "hemorrhaging", "and", "bone", "toxicity", "in", "rats", "fed", "diets", "deficient", "in", "vitamin", "K." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

autistic is a Participant_Condition, children ' s is a Participant_Age, Thai Traditional Massage ( TTM ) is a Intervention_Educational, 60 is a Participant_Sample-size, 3 and 10 is a Participant_Age, Standard sensory integration therapy ( SI ) is a Intervention_Educational, major behavior disturbances is a Outcome_Mental, Conners ' Rating Scales is a Outcome_Mental, Sleep Diary ( SD ) is a Outcome_Mental, Sixty ( 60 ) is a Participant_Sample-size, 4.67 + /- 1.82 is a Participant_Age, Conners ' Teacher Questionnaire is a Outcome_Mental, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior is a Outcome_Mental, Conners ' Parent Questionnaire is a Outcome_Mental, anxiety is a Outcome_Physical, stereotypical behaviors is a Outcome_Mental

43283_task0

Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .

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[ "Outcome_Mental", "Intervention_Educational", "Participant_Age", "Participant_Sample-size", "Participant_Condition", "Outcome_Physical" ]

autistic is a Participant_Condition, children ' s is a Participant_Age, Thai Traditional Massage ( TTM ) is a Intervention_Educational, 60 is a Participant_Sample-size, 3 and 10 is a Participant_Age, Standard sensory integration therapy ( SI ) is a Intervention_Educational, major behavior disturbances is a Outcome_Mental, Conners ' Rating Scales is a Outcome_Mental, Sleep Diary ( SD ) is a Outcome_Mental, Sixty ( 60 ) is a Participant_Sample-size, 4.67 + /- 1.82 is a Participant_Age, Conners ' Teacher Questionnaire is a Outcome_Mental, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior is a Outcome_Mental, Conners ' Parent Questionnaire is a Outcome_Mental, anxiety is a Outcome_Physical, stereotypical behaviors is a Outcome_Mental

43283_task1

Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . Instructions: please typing these entity words according to sentence: autistic, children ' s, Thai Traditional Massage ( TTM ), 60, 3 and 10, Standard sensory integration therapy ( SI ), major behavior disturbances, Conners ' Rating Scales, Sleep Diary ( SD ), Sixty ( 60 ), 4.67 + /- 1.82, Conners ' Teacher Questionnaire, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior, Conners ' Parent Questionnaire, anxiety, stereotypical behaviors Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .

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[ "Outcome_Mental", "Intervention_Educational", "Participant_Age", "Participant_Sample-size", "Participant_Condition", "Outcome_Physical" ]

autistic, children ' s, Thai Traditional Massage ( TTM ), 60, 3 and 10, Standard sensory integration therapy ( SI ), major behavior disturbances, Conners ' Rating Scales, Sleep Diary ( SD ), Sixty ( 60 ), 4.67 + /- 1.82, Conners ' Teacher Questionnaire, conduct problem , hyperactivity , inattention - passivity , hyperactivity index , and sleeping behavior, Conners ' Parent Questionnaire, anxiety, stereotypical behaviors

43283_task2

Sentence: Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand . Instructions: please extract entity words from the input sentence

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Effects of Thai traditional massage on autistic children 's behavior . OBJECTIVES The objective of this study was to access whether there were any therapeutic effects of Thai Traditional Massage ( TTM ) on major behavioral and emotional disturbances in Thai autistic children . DESIGN This was a randomized controlled trial study . SETTINGS/LOCATION The study was conducted at the Rehabilitation Centre of the Thai Red Cross Society . SUBJECTS A total of 60 autistic children between the ages of 3 and 10 completed this study . INTERVENTIONS Standard sensory integration therapy ( SI ) was compared to the SI with TTM treatments . OUTCOME MEASURES Parents and teachers assessed major behavior disturbances using the Conners ' Rating Scales at 0 and 8 weeks . Sleep Diary ( SD ) , recorded by the parents , assessed the patient 's sleeping patterns every week . RESULTS Sixty ( 60 ) autistic children , mean age 4.67 +/- 1.82 , were recruited . No statistical differences were seen in the demographic and baseline data among both groups . From both the Conners ' Teacher Questionnaire and SD , statistical improvement was detected for conduct problem , hyperactivity , inattention-passivity , hyperactivity index , and sleeping behavior . However , results from the Conners ' Parent Questionnaire revealed an improvement only for anxiety ( p = 0.04 ) in the massage group , whereas when both groups were compared , a significant improvement in conduct problem ( p = 0.03 ) and anxiety ( p = 0.01 ) was found . Results indicated that TTM may have a positive effect in improving stereotypical behaviors in autistic children . CONCLUSIONS Over a period of 8 weeks , our findings suggested that TTM could be used as a complementary therapy for autistic children in Thailand .

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[ "Outcome_Mental", "Intervention_Educational", "Participant_Age", "Participant_Sample-size", "Participant_Condition", "Outcome_Physical" ]

topical and / or systemic medication or mechanical devices is a Scope, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses is a Scope, females is a Person, active sexual life is a Observation, not is a Negation, contraceptive method is a Procedure, Female is a Person, pregnant is a Condition, lactating is a Condition, Female is a Person, positive is a Value, urine pregnancy test is a Measurement, Positive drug addictions is a Condition, verbal interrogatory is a Procedure, mentally disabled is a Condition, Serious tear film dysfunction syndrome is a Condition, TBUT is a Measurement, < 5 s is a Value, Schirmer is a Measurement, < 4 mm is a Value, OSDI is a Measurement, > 30 pints is a Value, Corneal staining is a Measurement, > grade III is a Value, Oxford scale is a Qualifier, Non perforated is a Qualifier, corneal ulcer is a Condition, Perforated is a Qualifier, corneal ulcer is a Condition, Autoimmune is a Qualifier, corneal ulcer is a Condition, Ocular surface scarring diseases is a Condition, Fibro vascular proliferation lesions is a Condition, conjunctival and / or corneal surface is a Scope, pterygium is a Qualifier, Concomitant is a Temporal, chronic inflammatory diseases is a Condition, ocular structure is a Qualifier, Acute or infectious is a Scope, inflammatory disease is a Condition, Corneal disease is a Condition, potentially requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, Ocular surgical procedures is a Procedure, 3 months before the protocol inclusion is a Temporal, Treatments or procedures is a Scope, tear film dysfunction treatment is a Procedure, punctal silicone plugs is a Device, Posterior segment diseases is a Condition, requiring a treatment or threatening the visual prognosis is a Scope, Retinal diseases is a Condition, requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, History is a Observation, penetrating keratoplasty is a Procedure, Soft or hard contact lenses is a Scope, during the last month from inclusion day is a Temporal

NCT03223909_exc_task0

Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Negation, Scope, Measurement, Device, Mood

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Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day

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[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]

topical and / or systemic medication or mechanical devices is a Scope, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses is a Scope, females is a Person, active sexual life is a Observation, not is a Negation, contraceptive method is a Procedure, Female is a Person, pregnant is a Condition, lactating is a Condition, Female is a Person, positive is a Value, urine pregnancy test is a Measurement, Positive drug addictions is a Condition, verbal interrogatory is a Procedure, mentally disabled is a Condition, Serious tear film dysfunction syndrome is a Condition, TBUT is a Measurement, < 5 s is a Value, Schirmer is a Measurement, < 4 mm is a Value, OSDI is a Measurement, > 30 pints is a Value, Corneal staining is a Measurement, > grade III is a Value, Oxford scale is a Qualifier, Non perforated is a Qualifier, corneal ulcer is a Condition, Perforated is a Qualifier, corneal ulcer is a Condition, Autoimmune is a Qualifier, corneal ulcer is a Condition, Ocular surface scarring diseases is a Condition, Fibro vascular proliferation lesions is a Condition, conjunctival and / or corneal surface is a Scope, pterygium is a Qualifier, Concomitant is a Temporal, chronic inflammatory diseases is a Condition, ocular structure is a Qualifier, Acute or infectious is a Scope, inflammatory disease is a Condition, Corneal disease is a Condition, potentially requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, Ocular surgical procedures is a Procedure, 3 months before the protocol inclusion is a Temporal, Treatments or procedures is a Scope, tear film dysfunction treatment is a Procedure, punctal silicone plugs is a Device, Posterior segment diseases is a Condition, requiring a treatment or threatening the visual prognosis is a Scope, Retinal diseases is a Condition, requiring is a Mood, treatment is a Procedure, during the following 3 months is a Temporal, History is a Observation, penetrating keratoplasty is a Procedure, Soft or hard contact lenses is a Scope, during the last month from inclusion day is a Temporal

NCT03223909_exc_task1

Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please typing these entity words according to sentence: topical and / or systemic medication or mechanical devices, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses, females, active sexual life, not, contraceptive method, Female, pregnant, lactating, Female, positive, urine pregnancy test, Positive drug addictions, verbal interrogatory, mentally disabled, Serious tear film dysfunction syndrome, TBUT, < 5 s, Schirmer, < 4 mm, OSDI, > 30 pints, Corneal staining, > grade III, Oxford scale, Non perforated, corneal ulcer, Perforated, corneal ulcer, Autoimmune, corneal ulcer, Ocular surface scarring diseases, Fibro vascular proliferation lesions, conjunctival and / or corneal surface, pterygium, Concomitant, chronic inflammatory diseases, ocular structure, Acute or infectious, inflammatory disease, Corneal disease, potentially requiring, treatment, during the following 3 months, Ocular surgical procedures, 3 months before the protocol inclusion, Treatments or procedures, tear film dysfunction treatment, punctal silicone plugs, Posterior segment diseases, requiring a treatment or threatening the visual prognosis, Retinal diseases, requiring, treatment, during the following 3 months, History, penetrating keratoplasty, Soft or hard contact lenses, during the last month from inclusion day Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Negation, Scope, Measurement, Device, Mood

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Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day

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[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]

topical and / or systemic medication or mechanical devices, topical immunomodulators , punctal plugs , corticosteroids , preservative artificial tears , contact lenses, females, active sexual life, not, contraceptive method, Female, pregnant, lactating, Female, positive, urine pregnancy test, Positive drug addictions, verbal interrogatory, mentally disabled, Serious tear film dysfunction syndrome, TBUT, < 5 s, Schirmer, < 4 mm, OSDI, > 30 pints, Corneal staining, > grade III, Oxford scale, Non perforated, corneal ulcer, Perforated, corneal ulcer, Autoimmune, corneal ulcer, Ocular surface scarring diseases, Fibro vascular proliferation lesions, conjunctival and / or corneal surface, pterygium, Concomitant, chronic inflammatory diseases, ocular structure, Acute or infectious, inflammatory disease, Corneal disease, potentially requiring, treatment, during the following 3 months, Ocular surgical procedures, 3 months before the protocol inclusion, Treatments or procedures, tear film dysfunction treatment, punctal silicone plugs, Posterior segment diseases, requiring a treatment or threatening the visual prognosis, Retinal diseases, requiring, treatment, during the following 3 months, History, penetrating keratoplasty, Soft or hard contact lenses, during the last month from inclusion day

NCT03223909_exc_task2

Sentence: Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day Instructions: please extract entity words from the input sentence

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Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses). Subjects (females) with active sexual life that do not use a contraceptive method. Female subjects who are pregnant or lactating Female subjects with a positive urine pregnancy test Positive drug addictions* (verbal interrogatory) Subjects who have participated on any other research clinical trials on the last 40 days Subjects legal or mentally disabled to give an informed consent for participating on this study Subjects who can't comply with the appointments or with every protocol requirement. Serious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale Non perforated corneal ulcer Perforated corneal ulcer Autoimmune corneal ulcer Ocular surface scarring diseases Ocular surface or annexes metaplastic lesions Fibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium) Concomitant chronic inflammatory diseases on any ocular structure Acute or infectious inflammatory disease Corneal disease potentially requiring a treatment during the following 3 months Use of topical or systemic drug products classified as forbidden Ocular surgical procedures 3 months before the protocol inclusion Treatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs. Posterior segment diseases requiring a treatment or threatening the visual prognosis Retinal diseases potentially requiring treatment during the following 3 months History of penetrating keratoplasty. Soft or hard contact lenses use during the last month from inclusion day

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[ "Scope", "Temporal", "Condition", "Procedure", "Drug", "Device", "Mood", "Measurement", "Observation", "Reference_point", "Qualifier", "Value", "Person", "Negation" ]

Kalkaneus is an umlsterm, Knochenzyste is an umlsterm, Fussskeletts is an umlsterm, Belastung is an umlsterm, Gelenkabstaende is an umlsterm, Zysten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, radiologisch is an umlsterm, Standardtherapie is an umlsterm, Becken is an umlsterm, Literatur is an umlsterm, Diagnostik is an umlsterm, Behandlung is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm

DerUnfallchirurg.91020576.ger.abstr_task0

Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .

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[ "umlsterm" ]

Kalkaneus is an umlsterm, Knochenzyste is an umlsterm, Fussskeletts is an umlsterm, Belastung is an umlsterm, Gelenkabstaende is an umlsterm, Zysten is an umlsterm, Behandlung is an umlsterm, Patienten is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, radiologisch is an umlsterm, Standardtherapie is an umlsterm, Becken is an umlsterm, Literatur is an umlsterm, Diagnostik is an umlsterm, Behandlung is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm, Fersenbeinzysten is an umlsterm, Diagnose is an umlsterm

DerUnfallchirurg.91020576.ger.abstr_task1

Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please typing these entity words according to sentence: Kalkaneus, Knochenzyste, Fussskeletts, Belastung, Gelenkabstaende, Zysten, Behandlung, Patienten, Fersenbeinzysten, Diagnose, radiologisch, Standardtherapie, Becken, Literatur, Diagnostik, Behandlung, Fersenbeinzysten, Diagnose, Fersenbeinzysten, Diagnose Options: umlsterm

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Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .

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[ "umlsterm" ]

Kalkaneus, Knochenzyste, Fussskeletts, Belastung, Gelenkabstaende, Zysten, Behandlung, Patienten, Fersenbeinzysten, Diagnose, radiologisch, Standardtherapie, Becken, Literatur, Diagnostik, Behandlung, Fersenbeinzysten, Diagnose, Fersenbeinzysten, Diagnose

DerUnfallchirurg.91020576.ger.abstr_task2

Sentence: Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich . Instructions: please extract entity words from the input sentence

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Der Kalkaneus ist eine ungewoehnliche Lokalisation fuer eine einkammrige , solitaere Knochenzyste . Aufgrund der Besonderheiten des Fussskeletts wie hoeherer statischer Belastung und geringer Gelenkabstaende kommt es hier schneller zu Beschwerden im Vergleich zu anderen Lokalisationen , deswegen beanspruchen diese Zysten meist eine chirurgische Behandlung , abhaengig natuerlich auch von der Groesse des Befunds . Wir berichten ueber 2 Patienten aus den Jahren 1996 und 1997 mit solitaeren Fersenbeinzysten . Die Diagnose wurde radiologisch und histologisch gesichert . Die Standardtherapie in beiden Faellen war die Kuerretage und die Auffuellung des Defekts mit autologer Spongiosa vom Becken . Der Autor gibt einen Ueberblick ueber die Literatur , ueber Diagnostik und Behandlung solitaerer Fersenbeinzysten . Die Diagnose kann nicht allein aufgrund des Roentgenbefunds sicher gestellt werden , da es weitgespannte Variationsmoeglichkeiten , wie z . B. verkalkende Fersenbeinzysten gibt . Deswegen ist die exakte histologische Diagnose zwingend erforderlich .

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[ "umlsterm" ]

CLNO2 is a compound, lipopolysaccharide is a compound, interferon - gamma is a protein, NOS2 is a protein, nitric oxide synthase is a protein, N(G)-nitro - L - arginine methyl ester is a compound

DS.d672_task0

Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]

CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).

[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]

[ "compound", "protein" ]

CLNO2 is a compound, lipopolysaccharide is a compound, interferon - gamma is a protein, NOS2 is a protein, nitric oxide synthase is a protein, N(G)-nitro - L - arginine methyl ester is a compound

DS.d672_task1

Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please typing these entity words according to sentence: CLNO2, lipopolysaccharide, interferon - gamma, NOS2, nitric oxide synthase, N(G)-nitro - L - arginine methyl ester Options: compound, protein

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]

CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).

[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]

[ "compound", "protein" ]

CLNO2, lipopolysaccharide, interferon - gamma, NOS2, nitric oxide synthase, N(G)-nitro - L - arginine methyl ester

DS.d672_task2

Sentence: CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester). Instructions: please extract entity words from the input sentence

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "I-compound", "O", "O" ]

CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).

[ "CLNO2", "levels", "were", "found", "to", "increase", "approximately", "20-fold", "24", "h", "after", "macrophage", "activation", "with", "Escherichia", "coli", "lipopolysaccharide", "plus", "interferon", "-", "gamma", ";", "this", "response", "was", "concurrent", "with", "an", "increase", "in", "the", "expression", "of", "NOS2", "(", "inducible", "nitric", "oxide", "synthase", ")", "and", "was", "inhibited", "by", "the", "(", "*", ")", "NO", "(", "nitric", "oxide", ")", "inhibitor", "L", "-", "NAME", "(", "N(G)-nitro", "-", "L", "-", "arginine", "methyl", "ester", ")", "." ]

[ "compound", "protein" ]

NF - kappaB - mediated up - regulation is a cell_type, Bcl - x is a protein_molecule, Bfl-1 / A1 is a protein_molecule, CD40 survival signaling is an other_name, B lymphocytes is a cell_type

34152_task0

Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, other_name, protein_molecule

[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.

[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]

[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]

NF - kappaB - mediated up - regulation is a cell_type, Bcl - x is a protein_molecule, Bfl-1 / A1 is a protein_molecule, CD40 survival signaling is an other_name, B lymphocytes is a cell_type

34152_task1

Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please typing these entity words according to sentence: NF - kappaB - mediated up - regulation, Bcl - x, Bfl-1 / A1, CD40 survival signaling, B lymphocytes Options: cell_type, other_name, protein_molecule

[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.

[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]

[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]

NF - kappaB - mediated up - regulation, Bcl - x, Bfl-1 / A1, CD40 survival signaling, B lymphocytes

34152_task2

Sentence: NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Instructions: please extract entity words from the input sentence

[ "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.

[ "NF", "-", "kappaB", "-", "mediated", "up", "-", "regulation", "of", "Bcl", "-", "x", "and", "Bfl-1", "/", "A1", "is", "required", "for", "CD40", "survival", "signaling", "in", "B", "lymphocytes", "." ]

[ "other_name", "protein_molecule", "cell_type", "DNA_domain_or_region", "protein_family_or_group", "protein_complex" ]

interleukin-8 AP-1 and kappa B - like sites is a (AND DNA_domain_or_region DNA_domain_or_region), FK506-sensitive pathway is an other_name, calcium mobilization is an other_name

13487_task0

Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: (AND DNA_domain_or_region DNA_domain_or_region), other_name

[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]

interleukin-8 AP-1 and kappa B - like sites is a (AND DNA_domain_or_region DNA_domain_or_region), FK506-sensitive pathway is an other_name, calcium mobilization is an other_name

13487_task1

Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please typing these entity words according to sentence: interleukin-8 AP-1 and kappa B - like sites, FK506-sensitive pathway, calcium mobilization Options: (AND DNA_domain_or_region DNA_domain_or_region), other_name

[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]

interleukin-8 AP-1 and kappa B - like sites, FK506-sensitive pathway, calcium mobilization

13487_task2

Sentence: The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. Instructions: please extract entity words from the input sentence

[ "O", "B-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "I-(AND DNA_domain_or_region DNA_domain_or_region)", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O" ]

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

[ "The", "interleukin-8", "AP-1", "and", "kappa", "B", "-", "like", "sites", "are", "genetic", "end", "targets", "of", "FK506-sensitive", "pathway", "accompanied", "by", "calcium", "mobilization", "." ]

[ "(AND DNA_domain_or_region DNA_domain_or_region)", "protein_complex", "other_organic_compound", "DNA_domain_or_region", "protein_family_or_group", "other_name", "", "cell_line", "cell_type", "protein_molecule", "atom" ]

choroidal neovascularization is a Condition, age - related is a Qualifier, macula degeneration is a Condition, no is a Negation, previous is a Temporal, treatment is a Procedure, follow - up is a Observation, at least 12 months is a Temporal, baseline is a Temporal, visual acuity is a Measurement, letter score of 0 to 70 is a Value, Early Treatment Diabetic Retinopathy Study chart is a Procedure

NCT01032109_inc_task0

Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Observation, Procedure, Negation, Measurement

[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]

choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart

[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]

[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]

choroidal neovascularization is a Condition, age - related is a Qualifier, macula degeneration is a Condition, no is a Negation, previous is a Temporal, treatment is a Procedure, follow - up is a Observation, at least 12 months is a Temporal, baseline is a Temporal, visual acuity is a Measurement, letter score of 0 to 70 is a Value, Early Treatment Diabetic Retinopathy Study chart is a Procedure

NCT01032109_inc_task1

Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please typing these entity words according to sentence: choroidal neovascularization, age - related, macula degeneration, no, previous, treatment, follow - up, at least 12 months, baseline, visual acuity, letter score of 0 to 70, Early Treatment Diabetic Retinopathy Study chart Options: Temporal, Condition, Qualifier, Value, Observation, Procedure, Negation, Measurement

[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]

choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart

[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]

[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]

choroidal neovascularization, age - related, macula degeneration, no, previous, treatment, follow - up, at least 12 months, baseline, visual acuity, letter score of 0 to 70, Early Treatment Diabetic Retinopathy Study chart

NCT01032109_inc_task2

Sentence: choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart Instructions: please extract entity words from the input sentence

[ "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Negation", "B-Temporal", "B-Procedure", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Temporal", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O" ]

choroidal neovascularization caused by age-related macula degeneration no previous treatment a follow-up at least 12 months a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart

[ "choroidal", "neovascularization", "caused", "by", "age", "-", "related", "macula", "degeneration", "\n", "no", "previous", "treatment", "\n", "a", "follow", "-", "up", "at", "least", "12", "months", "\n", "a", "baseline", "visual", "acuity", "ranging", "from", "a", "letter", "score", "of", "0", "to", "70", "on", "the", "Early", "Treatment", "Diabetic", "Retinopathy", "Study", "chart", "\n" ]

[ "Procedure", "Condition", "Value", "Temporal", "Measurement", "Qualifier", "Observation", "Negation" ]

Kopfschmerz is an umlsterm, Meningismus is an umlsterm, Fieber is an umlsterm, Computertomographie is an umlsterm, Subarachnoidalblutung is an umlsterm, Blutung is an umlsterm, Hydrozephalus is an umlsterm, Tumor is an umlsterm, Liquorpunktion is an umlsterm, Meningitis is an umlsterm, Meningoenzephalitis is an umlsterm, chronischen Kopfschmerzen is an umlsterm, Diagnose is an umlsterm, Charakter is an umlsterm, Kopfschmerzen is an umlsterm, Kopfschmerzen is an umlsterm

DerSchmerz.60100135.ger.abstr_task0

Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .

[ "Ein", "erstmals", "akut", "einsetzender", "heftiger", "Kopfschmerz", "insbesondere", "mit", "Meningismus", "oder", "Fieber", "bedarf", "einer", "sofortigen", "Abklaerung", "mit", "Hilfe", "von", "Computertomographie", "(", "CT", "Ausschluss", "Subarachnoidalblutung", ",", "Blutung", ",", "Hydrozephalus", ",", "Tumor", ")", ",", "und", "im", "Falle", "eines", "Normalbefundes", "einer", "Liquorpunktion", "(", "Ausschluss", "Meningitis", ",", "Meningoenzephalitis", ")", ".", "Bei", "chronisch", "rezidivierenden", "oder", "chronischen", "Kopfschmerzen", "ohne", "neurologische", "Ausfaelle", "und", "ohne", "psychopathologische", "Auffaelligkeiten", "sind", "technische", "Zusatzuntersuchungen", "entbehrlich", ".", "Hier", "stuetzt", "sich", "die", "Diagnose", "auf", "Anamnese", "und", "sorgfaeltige", "klinische", "Untersuchung", ".", "Ein", "CT", "ist", "nur", "dann", "erforderlich", ",", "wenn", "sich", "der", "Charakter", "der", "Kopfschmerzen", "eindeutig", "aendert", "oder", "wenn", "die", "Kopfschmerzen", "mit", "persistierenden", "neurologi-", "schen", "Herdsymptomen", "einher-", "gehen", "." ]

[ "umlsterm" ]

Kopfschmerz is an umlsterm, Meningismus is an umlsterm, Fieber is an umlsterm, Computertomographie is an umlsterm, Subarachnoidalblutung is an umlsterm, Blutung is an umlsterm, Hydrozephalus is an umlsterm, Tumor is an umlsterm, Liquorpunktion is an umlsterm, Meningitis is an umlsterm, Meningoenzephalitis is an umlsterm, chronischen Kopfschmerzen is an umlsterm, Diagnose is an umlsterm, Charakter is an umlsterm, Kopfschmerzen is an umlsterm, Kopfschmerzen is an umlsterm

DerSchmerz.60100135.ger.abstr_task1

Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please typing these entity words according to sentence: Kopfschmerz, Meningismus, Fieber, Computertomographie, Subarachnoidalblutung, Blutung, Hydrozephalus, Tumor, Liquorpunktion, Meningitis, Meningoenzephalitis, chronischen Kopfschmerzen, Diagnose, Charakter, Kopfschmerzen, Kopfschmerzen Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .

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[ "umlsterm" ]

Kopfschmerz, Meningismus, Fieber, Computertomographie, Subarachnoidalblutung, Blutung, Hydrozephalus, Tumor, Liquorpunktion, Meningitis, Meningoenzephalitis, chronischen Kopfschmerzen, Diagnose, Charakter, Kopfschmerzen, Kopfschmerzen

DerSchmerz.60100135.ger.abstr_task2

Sentence: Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen . Instructions: please extract entity words from the input sentence

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Ein erstmals akut einsetzender heftiger Kopfschmerz insbesondere mit Meningismus oder Fieber bedarf einer sofortigen Abklaerung mit Hilfe von Computertomographie ( CT Ausschluss Subarachnoidalblutung , Blutung , Hydrozephalus , Tumor ) , und im Falle eines Normalbefundes einer Liquorpunktion ( Ausschluss Meningitis , Meningoenzephalitis ) . Bei chronisch rezidivierenden oder chronischen Kopfschmerzen ohne neurologische Ausfaelle und ohne psychopathologische Auffaelligkeiten sind technische Zusatzuntersuchungen entbehrlich . Hier stuetzt sich die Diagnose auf Anamnese und sorgfaeltige klinische Untersuchung . Ein CT ist nur dann erforderlich , wenn sich der Charakter der Kopfschmerzen eindeutig aendert oder wenn die Kopfschmerzen mit persistierenden neurologi- schen Herdsymptomen einher- gehen .

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[ "umlsterm" ]

tamoxifen is a Intervention_Pharmacological, reducing the incidence of invasive breast cancer is a Outcome_Physical, reducing breast cancer mortality is a Outcome_Mortality, reducing deaths from cardiovascular disease is a Outcome_Mortality, reducing bone fractures is a Outcome_Physical, side effects , is a Outcome_Adverse-effects, toxicity is a Outcome_Mortality, quality of life is a Outcome_Other

84175_task0

Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Outcome_Other

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "B-Outcome_Mortality", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O" ]

National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .

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[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]

tamoxifen is a Intervention_Pharmacological, reducing the incidence of invasive breast cancer is a Outcome_Physical, reducing breast cancer mortality is a Outcome_Mortality, reducing deaths from cardiovascular disease is a Outcome_Mortality, reducing bone fractures is a Outcome_Physical, side effects , is a Outcome_Adverse-effects, toxicity is a Outcome_Mortality, quality of life is a Outcome_Other

84175_task1

Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please typing these entity words according to sentence: tamoxifen, reducing the incidence of invasive breast cancer, reducing breast cancer mortality, reducing deaths from cardiovascular disease, reducing bone fractures, side effects ,, toxicity, quality of life Options: Intervention_Pharmacological, Outcome_Adverse-effects, Outcome_Mortality, Outcome_Physical, Outcome_Other

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National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .

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[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]

tamoxifen, reducing the incidence of invasive breast cancer, reducing breast cancer mortality, reducing deaths from cardiovascular disease, reducing bone fractures, side effects ,, toxicity, quality of life

84175_task2

Sentence: National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants . Instructions: please extract entity words from the input sentence

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National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug , tamoxifen , can prevent breast cancer in high-risk women . The objectives of this trial are to determine whether tamoxifen is effective in 1 ) reducing the incidence of invasive breast cancer , 2 ) reducing breast cancer mortality , 3 ) reducing deaths from cardiovascular disease , and 4 ) reducing bone fractures . In addition , the study will evaluate side effects , toxicity , and the quality of life of all study participants .

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[ "Outcome_Physical", "Outcome_Mortality", "Outcome_Other", "Outcome_Adverse-effects", "Intervention_Pharmacological", "Participant_Condition" ]

development is an umlsterm, carcinoma is an umlsterm, pleomorphic adenoma is an umlsterm, minor salivary glands is an umlsterm, buccal mucosa is an umlsterm, female is an umlsterm, Tumor is an umlsterm, neoplasm is an umlsterm, pleomorphic adenoma is an umlsterm, minor is an umlsterm, carcinoma is an umlsterm, Recurrences is an umlsterm, tumor is an umlsterm, Histopathological is an umlsterm, tissue is an umlsterm, carcinoma is an umlsterm, minor salivary glands is an umlsterm, pleomorphic adenoma is an umlsterm, therapy is an umlsterm, diagnosis is an umlsterm, histopathology is an umlsterm, literature is an umlsterm

HNO.80460066.eng.abstr_task0

Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .

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[ "umlsterm" ]

development is an umlsterm, carcinoma is an umlsterm, pleomorphic adenoma is an umlsterm, minor salivary glands is an umlsterm, buccal mucosa is an umlsterm, female is an umlsterm, Tumor is an umlsterm, neoplasm is an umlsterm, pleomorphic adenoma is an umlsterm, minor is an umlsterm, carcinoma is an umlsterm, Recurrences is an umlsterm, tumor is an umlsterm, Histopathological is an umlsterm, tissue is an umlsterm, carcinoma is an umlsterm, minor salivary glands is an umlsterm, pleomorphic adenoma is an umlsterm, therapy is an umlsterm, diagnosis is an umlsterm, histopathology is an umlsterm, literature is an umlsterm

HNO.80460066.eng.abstr_task1

Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please typing these entity words according to sentence: development, carcinoma, pleomorphic adenoma, minor salivary glands, buccal mucosa, female, Tumor, neoplasm, pleomorphic adenoma, minor, carcinoma, Recurrences, tumor, Histopathological, tissue, carcinoma, minor salivary glands, pleomorphic adenoma, therapy, diagnosis, histopathology, literature Options: umlsterm

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We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .

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[ "umlsterm" ]

development, carcinoma, pleomorphic adenoma, minor salivary glands, buccal mucosa, female, Tumor, neoplasm, pleomorphic adenoma, minor, carcinoma, Recurrences, tumor, Histopathological, tissue, carcinoma, minor salivary glands, pleomorphic adenoma, therapy, diagnosis, histopathology, literature

HNO.80460066.eng.abstr_task2

Sentence: We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed . Instructions: please extract entity words from the input sentence

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We report the rare development of a myoepithelial carcinoma in a pleomorphic adenoma involving the minor salivary glands in the buccal mucosa of a 78-year-old female . Tumor presented as a small asymptomatic left buccal mass . The initial dominant component of the neoplasm was a pleomorphic adenoma , while the minor component was a myoepithelial carcinoma . Recurrences of tumor after 2 and then 5 years were excised . Histopathological examination of the last tissue removed showed a pure myoepithelial carcinoma of the minor salivary glands without evidence for a pleomorphic adenoma . The clinical features , therapy , diagnosis , histopathology and literature are reviewed .

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[ "umlsterm" ]

female is an umlsterm, patient is an umlsterm, melena is an umlsterm, cecum is an umlsterm, biopsies is an umlsterm, histiocytes is an umlsterm, diagnosis is an umlsterm, malakoplakia is an umlsterm, colon is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, melena is an umlsterm, period is an umlsterm, Malakoplakia is an umlsterm, inflammation is an umlsterm, colon is an umlsterm, diseases is an umlsterm, disorders is an umlsterm, defect is an umlsterm, syndromes is an umlsterm, heroin abuse is an umlsterm, alcohol abuse is an umlsterm, disease is an umlsterm

DerPathologe.90200351.eng.abstr_task0

Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .

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[ "umlsterm" ]

female is an umlsterm, patient is an umlsterm, melena is an umlsterm, cecum is an umlsterm, biopsies is an umlsterm, histiocytes is an umlsterm, diagnosis is an umlsterm, malakoplakia is an umlsterm, colon is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, melena is an umlsterm, period is an umlsterm, Malakoplakia is an umlsterm, inflammation is an umlsterm, colon is an umlsterm, diseases is an umlsterm, disorders is an umlsterm, defect is an umlsterm, syndromes is an umlsterm, heroin abuse is an umlsterm, alcohol abuse is an umlsterm, disease is an umlsterm

DerPathologe.90200351.eng.abstr_task1

Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please typing these entity words according to sentence: female, patient, melena, cecum, biopsies, histiocytes, diagnosis, malakoplakia, colon, antibiotic, therapy, melena, period, Malakoplakia, inflammation, colon, diseases, disorders, defect, syndromes, heroin abuse, alcohol abuse, disease Options: umlsterm

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We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .

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[ "umlsterm" ]

female, patient, melena, cecum, biopsies, histiocytes, diagnosis, malakoplakia, colon, antibiotic, therapy, melena, period, Malakoplakia, inflammation, colon, diseases, disorders, defect, syndromes, heroin abuse, alcohol abuse, disease

DerPathologe.90200351.eng.abstr_task2

Sentence: We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease . Instructions: please extract entity words from the input sentence

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We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease .

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[ "umlsterm" ]

BAG4 is a protein, Hsc70 is a protein, BAG1 is a protein

1.0alpha7.train.580_task0

Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).

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[ "protein" ]

BAG4 is a protein, Hsc70 is a protein, BAG1 is a protein

1.0alpha7.train.580_task1

Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please typing these entity words according to sentence: BAG4, Hsc70, BAG1 Options: protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).

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[ "protein" ]

BAG4, Hsc70, BAG1

1.0alpha7.train.580_task2

Sentence: Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hence, it can be predicted that BAG4 binds Hsc70 in a manner analogous to BAG1 ( 3, 15).

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[ "protein" ]

healing properties is a Outcome_Physical, superficial wounds . is a Participant_Condition, Ten is a Participant_Sample-size, polyurethane is a Intervention_Pharmacological, hydrocolloid is a Intervention_Pharmacological, hydrogel is a Intervention_Pharmacological, two standard plasters is a Intervention_Physical, Evaluation of wound healing is a Outcome_Physical, Visible re - epithelialisation is a Outcome_Physical, wound area had closed is a Outcome_Physical, cosmetic outcomes is a Outcome_Physical, Histological examination of biopsies is a Outcome_Physical, dermis remained intact is a Outcome_Physical, performance of plasters is a Outcome_Physical, healing outcomes is a Outcome_Physical, re - epithelialisation and overall cosmetic outcomes is a Outcome_Physical

39376_task0

Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size

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Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]

healing properties is a Outcome_Physical, superficial wounds . is a Participant_Condition, Ten is a Participant_Sample-size, polyurethane is a Intervention_Pharmacological, hydrocolloid is a Intervention_Pharmacological, hydrogel is a Intervention_Pharmacological, two standard plasters is a Intervention_Physical, Evaluation of wound healing is a Outcome_Physical, Visible re - epithelialisation is a Outcome_Physical, wound area had closed is a Outcome_Physical, cosmetic outcomes is a Outcome_Physical, Histological examination of biopsies is a Outcome_Physical, dermis remained intact is a Outcome_Physical, performance of plasters is a Outcome_Physical, healing outcomes is a Outcome_Physical, re - epithelialisation and overall cosmetic outcomes is a Outcome_Physical

39376_task1

Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please typing these entity words according to sentence: healing properties, superficial wounds ., Ten, polyurethane, hydrocolloid, hydrogel, two standard plasters, Evaluation of wound healing, Visible re - epithelialisation, wound area had closed, cosmetic outcomes, Histological examination of biopsies, dermis remained intact, performance of plasters, healing outcomes, re - epithelialisation and overall cosmetic outcomes Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size

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Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]

healing properties, superficial wounds ., Ten, polyurethane, hydrocolloid, hydrogel, two standard plasters, Evaluation of wound healing, Visible re - epithelialisation, wound area had closed, cosmetic outcomes, Histological examination of biopsies, dermis remained intact, performance of plasters, healing outcomes, re - epithelialisation and overall cosmetic outcomes

39376_task2

Sentence: Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities . Instructions: please extract entity words from the input sentence

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Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Intervention_Pharmacological", "Participant_Sample-size" ]

TRP channel is a GENE-N

23415228_task0

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]

A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.

[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TRP channel is a GENE-N

23415228_task1

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please typing these entity words according to sentence: TRP channel Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]

A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.

[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TRP channel

23415228_task2

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O" ]

A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.

[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

COL5A1 is a Gene, COL5A1 is a Gene, COL5A2 is a Gene, COL5A1 is a Gene, IVS4 - 2A-->G is a SNP, COL5A1 is a Gene

305_task0

Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP

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Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.

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[ "SNP", "Gene" ]

COL5A1 is a Gene, COL5A1 is a Gene, COL5A2 is a Gene, COL5A1 is a Gene, IVS4 - 2A-->G is a SNP, COL5A1 is a Gene

305_task1

Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please typing these entity words according to sentence: COL5A1, COL5A1, COL5A2, COL5A1, IVS4 - 2A-->G, COL5A1 Options: Gene, SNP

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Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.

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[ "SNP", "Gene" ]

COL5A1, COL5A1, COL5A2, COL5A1, IVS4 - 2A-->G, COL5A1

305_task2

Sentence: Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. Instructions: please extract entity words from the input sentence

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Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.

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[ "SNP", "Gene" ]

ulna is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm

Trauma+Berufskrankheit.80010040.eng.abstr_task0

Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The significance of the styloid process of the ulna in the treatment of distal radius fractures .

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[ "umlsterm" ]

ulna is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm

Trauma+Berufskrankheit.80010040.eng.abstr_task1

Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please typing these entity words according to sentence: ulna, treatment, radius fractures Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The significance of the styloid process of the ulna in the treatment of distal radius fractures .

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[ "umlsterm" ]

ulna, treatment, radius fractures

Trauma+Berufskrankheit.80010040.eng.abstr_task2

Sentence: The significance of the styloid process of the ulna in the treatment of distal radius fractures . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The significance of the styloid process of the ulna in the treatment of distal radius fractures .

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[ "umlsterm" ]

dual - axis rotational coronary angiography ( XPERSWING ) is a Intervention_Physical, conventional is a Intervention_Physical, Rotational angiography is a Intervention_Physical, conventional coronary angiography ( A ) vs rotational angiography is a Intervention_Physical, amount of contrast administered is a Outcome_Other, total procedure time is a Outcome_Other, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized is a Participant_Condition, radiation exposure is a Outcome_Other, Angioplasty is a Outcome_Physical, Contrast reduction is a Outcome_Other, contrast dose is a Outcome_Other

54342_task0

Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Other, Outcome_Physical, Participant_Condition

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Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Other", "Outcome_Physical" ]

dual - axis rotational coronary angiography ( XPERSWING ) is a Intervention_Physical, conventional is a Intervention_Physical, Rotational angiography is a Intervention_Physical, conventional coronary angiography ( A ) vs rotational angiography is a Intervention_Physical, amount of contrast administered is a Outcome_Other, total procedure time is a Outcome_Other, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized is a Participant_Condition, radiation exposure is a Outcome_Other, Angioplasty is a Outcome_Physical, Contrast reduction is a Outcome_Other, contrast dose is a Outcome_Other

54342_task1

Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please typing these entity words according to sentence: dual - axis rotational coronary angiography ( XPERSWING ), conventional, Rotational angiography, conventional coronary angiography ( A ) vs rotational angiography, amount of contrast administered, total procedure time, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized, radiation exposure, Angioplasty, Contrast reduction, contrast dose Options: Intervention_Physical, Outcome_Other, Outcome_Physical, Participant_Condition

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Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Other", "Outcome_Physical" ]

dual - axis rotational coronary angiography ( XPERSWING ), conventional, Rotational angiography, conventional coronary angiography ( A ) vs rotational angiography, amount of contrast administered, total procedure time, Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized, radiation exposure, Angioplasty, Contrast reduction, contrast dose

54342_task2

Sentence: Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Comparison of dual-axis rotational coronary angiography ( XPERSWING ) versus conventional technique in routine practice . INTRODUCTION AND OBJECTIVES Coronary angiography is the gold standard for the study of coronary artery disease . This technique requires several orthogonal projections . Rotational angiography is a new technique which involves pre-set rotation of the X-ray tube around the patient and allows visualization of each coronary artery in different views , using a single contrast injection . The purpose of this study was to compare conventional coronary angiography ( A ) vs rotational angiography ( B ) , focusing on radiation dose , amount of contrast administered , and total procedure time for both diagnostic and therapeutic percutaneous coronary interventions . METHODS Prospective study of 104 consecutive patients undergoing coronary angiography who were randomized to one of these techniques . RESULTS We found a significant reduction in the amount of contrast administered ( A vs B , 93.1 [ 41.7 ] vs 50.9 [ 14.7 ] mL ; P < .0001 ) and radiation exposure ( 27.6 [ 11.5 ] vs 18 [ 6.4 ] mGycm ( 2 ) ; P < .0001 ) . A significant increase in total procedure time was noted in the rotational angiography arm . However , when only the last 50 patients were analyzed , we found no difference in procedure time between the groups , probably related to the learning curve of the operators . Angioplasty was performed in 29 patients in group A and 28 patients in group B . Contrast reduction was maintained in the rotational angiography group compared to the conventional technique ( A vs B , 335.1 [ 192.1 ] vs 238.5 [ 114.4 ] mL ; P=.02 ) . CONCLUSIONS The rotational angiography technique leads to a significant decrease in radiation exposure and contrast dose administered for diagnostic procedures when compared to conventional coronary angiography . In patients who undergo percutaneous coronary intervention , contrast reduction remains significant .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Other", "Outcome_Physical" ]

Mitogen activation is an other_name, human peripheral T lymphocytes is a cell_type, cyclic AMP response element - binding protein nuclear complexes is a protein_complex

12099_task0

Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_complex, cell_type, other_name

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.

[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]

[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]

Mitogen activation is an other_name, human peripheral T lymphocytes is a cell_type, cyclic AMP response element - binding protein nuclear complexes is a protein_complex

12099_task1

Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please typing these entity words according to sentence: Mitogen activation, human peripheral T lymphocytes, cyclic AMP response element - binding protein nuclear complexes Options: protein_complex, cell_type, other_name

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.

[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]

[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]

Mitogen activation, human peripheral T lymphocytes, cyclic AMP response element - binding protein nuclear complexes

12099_task2

Sentence: Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes. Instructions: please extract entity words from the input sentence

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.

[ "Mitogen", "activation", "of", "human", "peripheral", "T", "lymphocytes", "induces", "the", "formation", "of", "new", "cyclic", "AMP", "response", "element", "-", "binding", "protein", "nuclear", "complexes", "." ]

[ "protein_complex", "protein_molecule", "DNA_domain_or_region", "other_name", "cell_type", "protein_family_or_group", "cell_component", "polynucleotide", "cell_line", "nucleotide", "other_organic_compound" ]

rehabilitation is an umlsterm, defects is an umlsterm, malformations is an umlsterm, development is an umlsterm, silicones is an umlsterm, titanium is an umlsterm, prostheses is an umlsterm, production is an umlsterm, techniques is an umlsterm, defects is an umlsterm, ear is an umlsterm, nose is an umlsterm, orbit is an umlsterm, prostheses is an umlsterm, plastic surgery is an umlsterm, recognition is an umlsterm, recurrences is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, contraindications is an umlsterm, patients is an umlsterm, prostheses is an umlsterm, University is an umlsterm, Germany is an umlsterm

HNO.80460569.eng.abstr_task0

Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .

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[ "umlsterm" ]

rehabilitation is an umlsterm, defects is an umlsterm, malformations is an umlsterm, development is an umlsterm, silicones is an umlsterm, titanium is an umlsterm, prostheses is an umlsterm, production is an umlsterm, techniques is an umlsterm, defects is an umlsterm, ear is an umlsterm, nose is an umlsterm, orbit is an umlsterm, prostheses is an umlsterm, plastic surgery is an umlsterm, recognition is an umlsterm, recurrences is an umlsterm, tumor is an umlsterm, surgery is an umlsterm, contraindications is an umlsterm, patients is an umlsterm, prostheses is an umlsterm, University is an umlsterm, Germany is an umlsterm

HNO.80460569.eng.abstr_task1

Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please typing these entity words according to sentence: rehabilitation, defects, malformations, development, silicones, titanium, prostheses, production, techniques, defects, ear, nose, orbit, prostheses, plastic surgery, recognition, recurrences, tumor, surgery, contraindications, patients, prostheses, University, Germany Options: umlsterm

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The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .

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[ "umlsterm" ]

rehabilitation, defects, malformations, development, silicones, titanium, prostheses, production, techniques, defects, ear, nose, orbit, prostheses, plastic surgery, recognition, recurrences, tumor, surgery, contraindications, patients, prostheses, University, Germany

HNO.80460569.eng.abstr_task2

Sentence: The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The prosthetic rehabilitation of cranio-facial defects and malformations has made enormous progress with the development of currently available silicones and the discovery of titanium as an optimally bicompatible implant material . This allows for a reliable , solid fixation of cranio-facial prostheses , which , due to modern production techniques , give outstanding camouflage to defects . To reconstruct such complex aesthetic entities as the ear , nose and orbit , bone-anchored prostheses now represent more than just an alternative to plastic surgery . Their removal also allows early recognition of recurrences following tumor surgery . The principles of implantology and all commercially available systems are presented , as well as indications , contraindications and our personal experience with 120 patients who received bone-anchored prostheses at the ENT Department of the University of Saarland in Homburg , Germany .

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[ "umlsterm" ]

Ikaros is a protein_molecule, Aiolos is a protein_molecule, histone deacetylase complexes is a protein_complex

39289_task0

Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_complex, protein_molecule

[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]

[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]

Ikaros is a protein_molecule, Aiolos is a protein_molecule, histone deacetylase complexes is a protein_complex

39289_task1

Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please typing these entity words according to sentence: Ikaros, Aiolos, histone deacetylase complexes Options: protein_complex, protein_molecule

[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]

[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]

Ikaros, Aiolos, histone deacetylase complexes

39289_task2

Sentence: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "B-protein_complex", "I-protein_complex", "I-protein_complex", "O" ]

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

[ "Repression", "by", "Ikaros", "and", "Aiolos", "is", "mediated", "through", "histone", "deacetylase", "complexes", "." ]

[ "protein_family_or_group", "other_organic_compound", "protein_complex", "other_name", "protein_molecule", "protein_domain_or_region", "DNA_domain_or_region" ]

histologic is an umlsterm, determination is an umlsterm, tissue is an umlsterm, anaplasia is an umlsterm, malignancy is an umlsterm, gliomas is an umlsterm, mitoses is an umlsterm, tumor is an umlsterm, necrosis is an umlsterm, weighting is an umlsterm, criteria is an umlsterm, weighting is an umlsterm, procedure is an umlsterm, classification is an umlsterm, brain tumors is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, mixed gliomas is an umlsterm, glioma is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, glioma is an umlsterm, tumor is an umlsterm, contrast is an umlsterm, MRI is an umlsterm, criterion is an umlsterm, tumor is an umlsterm, malignancy is an umlsterm

DerPathologe.80190259.eng.abstr_task0

Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .

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[ "umlsterm" ]

histologic is an umlsterm, determination is an umlsterm, tissue is an umlsterm, anaplasia is an umlsterm, malignancy is an umlsterm, gliomas is an umlsterm, mitoses is an umlsterm, tumor is an umlsterm, necrosis is an umlsterm, weighting is an umlsterm, criteria is an umlsterm, weighting is an umlsterm, procedure is an umlsterm, classification is an umlsterm, brain tumors is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, mixed gliomas is an umlsterm, glioma is an umlsterm, astrocytomas is an umlsterm, oligodendrogliomas is an umlsterm, glioma is an umlsterm, tumor is an umlsterm, contrast is an umlsterm, MRI is an umlsterm, criterion is an umlsterm, tumor is an umlsterm, malignancy is an umlsterm

DerPathologe.80190259.eng.abstr_task1

Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please typing these entity words according to sentence: histologic, determination, tissue, anaplasia, malignancy, gliomas, mitoses, tumor, necrosis, weighting, criteria, weighting, procedure, classification, brain tumors, astrocytomas, oligodendrogliomas, mixed gliomas, glioma, astrocytomas, oligodendrogliomas, glioma, tumor, contrast, MRI, criterion, tumor, malignancy Options: umlsterm

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The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .

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[ "umlsterm" ]

histologic, determination, tissue, anaplasia, malignancy, gliomas, mitoses, tumor, necrosis, weighting, criteria, weighting, procedure, classification, brain tumors, astrocytomas, oligodendrogliomas, mixed gliomas, glioma, astrocytomas, oligodendrogliomas, glioma, tumor, contrast, MRI, criterion, tumor, malignancy

DerPathologe.80190259.eng.abstr_task2

Sentence: The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade . Instructions: please extract entity words from the input sentence

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The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only " low-grade " and " high-grade " cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the " high " malignancy grade .

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[ "umlsterm" ]

Kerlone is a BRAND, cimetidine is a DRUG, nifedipine is a DRUG, chlorthalidone is a DRUG, hydrochlorothiazide is a DRUG, Kerlone is a BRAND, anticoagulant is a GROUP, warfarin is a DRUG, warfarin is a DRUG, reserpine is a DRUG, beta - blocking is a DRUG, beta - adrenergic receptor blocking agent is a GROUP, beta - blockers is a GROUP, clonidine is a DRUG, beta - blocker is a GROUP, clonidine is a DRUG, calcium antagonists is a GROUP, beta - adrenergic blocking agents is a GROUP, beta - adrenergic blocking agents is a GROUP, calcium antagonist is a GROUP, calcium antagonist is a GROUP, dihydropyridine derivative is a GROUP, nifedipine is a DRUG, verapamil is a DRUG, diltiazem is a DRUG, beta - blockers is a GROUP, epinephrine is a DRUG, beta - blockers is a GROUP, beta - blockers is a GROUP, epinephrine is a DRUG

Betaxolol_ddi_task0

Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG, BRAND

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The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.

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[ "GROUP", "DRUG", "BRAND" ]

Kerlone is a BRAND, cimetidine is a DRUG, nifedipine is a DRUG, chlorthalidone is a DRUG, hydrochlorothiazide is a DRUG, Kerlone is a BRAND, anticoagulant is a GROUP, warfarin is a DRUG, warfarin is a DRUG, reserpine is a DRUG, beta - blocking is a DRUG, beta - adrenergic receptor blocking agent is a GROUP, beta - blockers is a GROUP, clonidine is a DRUG, beta - blocker is a GROUP, clonidine is a DRUG, calcium antagonists is a GROUP, beta - adrenergic blocking agents is a GROUP, beta - adrenergic blocking agents is a GROUP, calcium antagonist is a GROUP, calcium antagonist is a GROUP, dihydropyridine derivative is a GROUP, nifedipine is a DRUG, verapamil is a DRUG, diltiazem is a DRUG, beta - blockers is a GROUP, epinephrine is a DRUG, beta - blockers is a GROUP, beta - blockers is a GROUP, epinephrine is a DRUG

Betaxolol_ddi_task1

Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please typing these entity words according to sentence: Kerlone, cimetidine, nifedipine, chlorthalidone, hydrochlorothiazide, Kerlone, anticoagulant, warfarin, warfarin, reserpine, beta - blocking, beta - adrenergic receptor blocking agent, beta - blockers, clonidine, beta - blocker, clonidine, calcium antagonists, beta - adrenergic blocking agents, beta - adrenergic blocking agents, calcium antagonist, calcium antagonist, dihydropyridine derivative, nifedipine, verapamil, diltiazem, beta - blockers, epinephrine, beta - blockers, beta - blockers, epinephrine Options: GROUP, DRUG, BRAND

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The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.

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[ "GROUP", "DRUG", "BRAND" ]

Kerlone, cimetidine, nifedipine, chlorthalidone, hydrochlorothiazide, Kerlone, anticoagulant, warfarin, warfarin, reserpine, beta - blocking, beta - adrenergic receptor blocking agent, beta - blockers, clonidine, beta - blocker, clonidine, calcium antagonists, beta - adrenergic blocking agents, beta - adrenergic blocking agents, calcium antagonist, calcium antagonist, dihydropyridine derivative, nifedipine, verapamil, diltiazem, beta - blockers, epinephrine, beta - blockers, beta - blockers, epinephrine

Betaxolol_ddi_task2

Sentence: The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. Instructions: please extract entity words from the input sentence

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The following drugs have been coadministered with Kerlone and have not altered its pharmacokinetics: cimetidine, nifedipine, chlorthalidone, and hydrochlorothiazide. Concomitant administration of Kerlone with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with a beta-adrenergic receptor blocking agent plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine. Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen. Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e.g., nifedipine, while left ventricular failure and AV conduction disturbances, including complete heart block, were more likely to occur with either verapamil or diltiazem. Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks. Severe allergic reactions including anaphylaxis have been reported in patients exposed to a variety of allergens either by repeated challenge, or accidental contact, and with diagnostic or therapeutic agents while receiving beta-blockers. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.

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[ "GROUP", "DRUG", "BRAND" ]

NADA is a compound, cytochrome P450 is a protein

DS.d1295_task0

Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.

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[ "protein", "compound" ]

NADA is a compound, cytochrome P450 is a protein

DS.d1295_task1

Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please typing these entity words according to sentence: NADA, cytochrome P450 Options: compound, protein

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.

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[ "protein", "compound" ]

NADA, cytochrome P450

DS.d1295_task2

Sentence: To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.

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[ "protein", "compound" ]

ambulanter Chirurgie is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Maennern is an umlsterm, Maenner is an umlsterm, Aengstlichkeit is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerzempfindung is an umlsterm, Atemdepression is an umlsterm, Sauerstoffsaettigung is an umlsterm, Blutdruck is an umlsterm, Konzentrationstest is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm, Sicherheit is an umlsterm, Patienten is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm

DerAnaesthesist.60450826.ger.abstr_task0

Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .

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[ "umlsterm" ]

ambulanter Chirurgie is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Maennern is an umlsterm, Maenner is an umlsterm, Aengstlichkeit is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerzempfindung is an umlsterm, Atemdepression is an umlsterm, Sauerstoffsaettigung is an umlsterm, Blutdruck is an umlsterm, Konzentrationstest is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Praemedikation is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm, Sicherheit is an umlsterm, Patienten is an umlsterm, Midazolam is an umlsterm, Patienten is an umlsterm

DerAnaesthesist.60450826.ger.abstr_task1

Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please typing these entity words according to sentence: ambulanter Chirurgie, Praemedikation, Midazolam, Maennern, Maenner, Aengstlichkeit, Merkfaehigkeit, Schmerzempfindung, Atemdepression, Sauerstoffsaettigung, Blutdruck, Konzentrationstest, Praemedikation, Praemedikation, Praemedikation, Midazolam, Patienten, Sicherheit, Patienten, Midazolam, Patienten Options: umlsterm

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Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .

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[ "umlsterm" ]

ambulanter Chirurgie, Praemedikation, Midazolam, Maennern, Maenner, Aengstlichkeit, Merkfaehigkeit, Schmerzempfindung, Atemdepression, Sauerstoffsaettigung, Blutdruck, Konzentrationstest, Praemedikation, Praemedikation, Praemedikation, Midazolam, Patienten, Sicherheit, Patienten, Midazolam, Patienten

DerAnaesthesist.60450826.ger.abstr_task2

Sentence: Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig . Instructions: please extract entity words from the input sentence

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Insbesondere unter dem Aspekt ambulanter Chirurgie sollte ueberprueft werden , inwieweit eine orale Praemedikation mit 3,75 mg Midazolam bei Maennern ueber 60 Jahre perioperativ kognitive und physiologische Funktionen veraendert . In einer randomisierten , doppelt maskierten und plazebokontrollierten Studie wurden insgesamt 47 Maenner ( Alter > 60 Jahre , Gewicht 50 bis 90 kg ) untersucht , bei denen ein intraokularer Eingriff in Retrobulbaeranaesthesie durchgefuehrt wurde . Folgende Messgroessen wurden bestimmt Sedierung ( : Rangskalierung mit 5 Stufen Aengstlichkeit ( visuelle Analogskala ) , Merkfaehigkeit ( ) , Zahlennachsprechen Konzentrationsfaehigkeit ( ) , Revisionstest nach Stender u. Marschner Langzeitgedaechtnis ( Wortmerktest ) und Schmerzempfindung ( ) , visuelle Analogskala ) . Zur Erfassung einer intraoperativen Atemdepression wurden intraoperativ pulsoxymetrische Sauerstoffsaettigung und endexspiratorischer pCO2 ( nasal ) kontrolliert . Eine halbe Stunde nach Midazolam-Praemedikation war die Sedierung signifikant staerker ( p 0,01 ) ausgepraegt und der systolische Blutdruck signifikant niedriger ( p 0,05 ) als in der Plazebogruppe . Bei den kognitiven Funktionstests fanden sich nur 1/2 h nach Midazolam-Praemedikation signifikante Unterschiede im Konzentrationstest nach Stender u. Marschner ( p 0,05 ) . 2 h nach Operation ( 293 +/- 41 min nach Praemedikation ) zeigten sich keine Veraenderungen der physiologischen und kognitiven Funktionen . Da kognitive und physiologische Funktionen unmittelbar nach der Praemedikation geringfuegig eingeschraenkt sind , postoperativ aber keine Veraenderungen dieser Funktionen nachzuweisen sind , erscheint eine orale Praemedikation mit durchschnittlich 0,049 +/- 0,006 mg/kg Midazolam fuer ambulante Eingriffe bei aelteren Patienten geeignet zu sein . Zugunsten der Sicherheit des Patienten ist bei routinemaessigem Einsatz von 3,75 mg Midazolam die Praemedikationsdosis bei einem Teil der Patienten vermutlich zu niedrig .

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[ "umlsterm" ]

Gestationsalter is an umlsterm, Bupivacain is an umlsterm, Leistenhernienoperation is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Adrenalin is an umlsterm, Zeit is an umlsterm, Injektion is an umlsterm, Beine is an umlsterm, EKG is an umlsterm, Blutdruckwerte is an umlsterm, Lumbalpunktion is an umlsterm, Injektion is an umlsterm, Blutdruckwerten is an umlsterm

DerAnaesthesist.40430026.ger.abstr_task0

Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .

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[ "umlsterm" ]

Gestationsalter is an umlsterm, Bupivacain is an umlsterm, Leistenhernienoperation is an umlsterm, Patienten is an umlsterm, Bupivacain is an umlsterm, Adrenalin is an umlsterm, Zeit is an umlsterm, Injektion is an umlsterm, Beine is an umlsterm, EKG is an umlsterm, Blutdruckwerte is an umlsterm, Lumbalpunktion is an umlsterm, Injektion is an umlsterm, Blutdruckwerten is an umlsterm

DerAnaesthesist.40430026.ger.abstr_task1

Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please typing these entity words according to sentence: Gestationsalter, Bupivacain, Leistenhernienoperation, Patienten, Bupivacain, Adrenalin, Zeit, Injektion, Beine, EKG, Blutdruckwerte, Lumbalpunktion, Injektion, Blutdruckwerten Options: umlsterm

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Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .

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[ "umlsterm" ]

Gestationsalter, Bupivacain, Leistenhernienoperation, Patienten, Bupivacain, Adrenalin, Zeit, Injektion, Beine, EKG, Blutdruckwerte, Lumbalpunktion, Injektion, Blutdruckwerten

DerAnaesthesist.40430026.ger.abstr_task2

Sentence: Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe . Instructions: please extract entity words from the input sentence

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Bei 10 ehemaligen Fruehgeborenen mit einem Gestationsalter zwischen 38 und 48 Wochen am Operationstag und einem Gewicht zwischen 2,10 und 3,22 kg , die postpartal respiratorische Adaptationsstoerungen aufwiesen , wurde nach elterlichem Einverstaendnis eine Spinalanaesthesie mit 0,6 ml Bupivacain 0,5% fuer eine Leistenhernienoperation durchgefuehrt . Jeweils 5 Patienten erhielten Bupivacain ohne Adrenalinzusatz ( Gruppe I ) bzw. mit Adrenalin 1 200 000=5 µg/ml ( : Gruppe II ) . Die Wirkdauer wurde definiert als Zeit von der Injektion bis zur ersten Bewegung der Beine : Die ueber das EKG registrierte Herzfrequenz und die oszillometrisch gemessenen Blutdruckwerte wurden vor Lagerung zur Lumbalpunktion sowie 2 , 5 , 10 und 20 min nach der Injektion des Lokalanaesthetikums erhoben . Die Wirkdauer einer Spinalanaesthesie war im Median in der Gruppe II mit 95 min ( 60 - 120 ) signifikant laenger als in der Gruppe I mit 50 min ( 37 - 85 ) . Keine signifikanten Unterschiede zeigten sich bei Herzfrequenz und Blutdruckwerten - weder zwischen den Gruppen noch im zeitlichen Verlauf einer Gruppe .

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[ "umlsterm" ]

anticuerpos antitransglutaminasa is a PROTEINAS, gluten is a UNCLEAR, anticuerpos anticardiolipina is a PROTEINAS, IgG is a PROTEINAS, anticardiolipina is a PROTEINAS, IgM is a PROTEINAS, ácido acetilsalicílico is a NORMALIZABLES

291_task0

Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: UNCLEAR, NORMALIZABLES, PROTEINAS

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Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.

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[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]

anticuerpos antitransglutaminasa is a PROTEINAS, gluten is a UNCLEAR, anticuerpos anticardiolipina is a PROTEINAS, IgG is a PROTEINAS, anticardiolipina is a PROTEINAS, IgM is a PROTEINAS, ácido acetilsalicílico is a NORMALIZABLES

291_task1

Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please typing these entity words according to sentence: anticuerpos antitransglutaminasa, gluten, anticuerpos anticardiolipina, IgG, anticardiolipina, IgM, ácido acetilsalicílico Options: UNCLEAR, NORMALIZABLES, PROTEINAS

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Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.

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[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]

anticuerpos antitransglutaminasa, gluten, anticuerpos anticardiolipina, IgG, anticardiolipina, IgM, ácido acetilsalicílico

291_task2

Sentence: Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-UNCLEAR", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Paciente mujer, edad 26 años, diagnosticada de enfermedad celiaca con anticuerpos antitransglutaminasa 73 U (valor normal hasta 10) y biopsia duodenal con enteropatía con atrofia vellocitaria severa (grado III). Presentó buena evolución con dieta libre de gluten, desapareciendo diarrea y mejorando estado nutricional. Seis meses después la paciente queda embarazada, presentando muerte fetal a las 36 semanas. Al año siguiente presenta nuevo embarazo. Se determinan anticuerpos anticardiolipina IgG: 20 GPL U/ml (v.n. < 11) y anticardiolipina IgM: 9 MPL U/ml (v.n. < 10). El estudio hematológico no evidenció otras alteraciones protrombóticas. Se la medica con ácido acetilsalicílico a dosis de 200 mg/día presentando embarazo y nacimiento por cesárea normales.

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[ "PROTEINAS", "NORMALIZABLES", "UNCLEAR" ]

Magnetic resonance imaging is a Intervention_Physical, otospongiosis : is a Participant_Condition, magnetic resonance imaging ( MRI ) is a Intervention_Physical, Twenty - six is a Participant_Sample-size, n = 42 ears is a Participant_Sample-size, otosclerosis is a Participant_Condition, computed tomography is a Intervention_Physical, placebo is a Intervention_Control, sodium alendronate is a Intervention_Pharmacological, sodium fluoride is a Intervention_Pharmacological

70571_task0

Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Intervention_Control, Participant_Condition, Participant_Sample-size

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Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .

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[ "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size", "Intervention_Control" ]

Magnetic resonance imaging is a Intervention_Physical, otospongiosis : is a Participant_Condition, magnetic resonance imaging ( MRI ) is a Intervention_Physical, Twenty - six is a Participant_Sample-size, n = 42 ears is a Participant_Sample-size, otosclerosis is a Participant_Condition, computed tomography is a Intervention_Physical, placebo is a Intervention_Control, sodium alendronate is a Intervention_Pharmacological, sodium fluoride is a Intervention_Pharmacological

70571_task1

Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please typing these entity words according to sentence: Magnetic resonance imaging, otospongiosis :, magnetic resonance imaging ( MRI ), Twenty - six, n = 42 ears, otosclerosis, computed tomography, placebo, sodium alendronate, sodium fluoride Options: Intervention_Pharmacological, Intervention_Physical, Intervention_Control, Participant_Condition, Participant_Sample-size

[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .

[ "Magnetic", "resonance", "imaging", "in", "the", "evaluation", "of", "clinical", "treatment", "of", "otospongiosis", ":", "a", "pilot", "study", ".", "OBJECTIVES", "To", "evaluate", "the", "applicability", "of", "magnetic", "resonance", "imaging", "(", "MRI", ")", "as", "a", "method", "for", "monitoring", "the", "activity", "of", "otospongiotic", "lesions", "before", "and", "after", "clinical", "treatment", ".", "STUDY", "DESIGN", "Prospective", ",", "randomized", ",", "controlled", ",", "double", "-", "blind", "study", ".", "SETTING", "One", "single", "tertiary", "care", "institution", "in", "a", "large", ",", "cosmopolitan", "city", ".", "METHODS", "Twenty", "-", "six", "patients", "(", "n", "=", "42", "ears", ")", "with", "clinical", ",", "audiometric", ",", "and", "tomographic", "diagnosis", "of", "otosclerosis", "were", "enrolled", ".", "If", "computed", "tomography", "(", "CT", ")", "demonstrated", "active", "lesions", ",", "these", "patients", "underwent", "MRI", "to", "detect", "otospongiotic", "foci", ",", "seen", "as", "areas", "of", "gadolinium", "enhancement", ".", "Patients", "were", "divided", "into", "3", "groups", "and", "received", "treatment", "with", "placebo", ",", "sodium", "alendronate", ",", "or", "sodium", "fluoride", "for", "6", "months", ".", "After", "this", "period", ",", "clinical", "and", "audiometric", "evaluations", "and", "a", "second", "MRI", "were", "performed", ".", "Each", "MRI", "was", "evaluated", "by", "both", "a", "neuroradiologist", "and", "an", "otolaryngologist", "in", "a", "subjective", "(", "visual", ")", "and", "objective", "(", "using", "specific", "eFilm", "Workstation", "software", ")", "manner", ".", "RESULTS", "Otospongiosis", "was", "most", "predominantly", "identified", "in", "the", "region", "anterior", "to", "the", "oval", "window", ",", "and", "this", "site", "was", "reliable", "for", "comparing", "pre-", "and", "posttreatment", "scans", ".", "The", "patients", "in", "the", "alendronate", "and", "sodium", "fluoride", "groups", "had", "MRI", "findings", "that", "suggested", "a", "decrease", "in", "activity", "of", "otospongiotic", "lesions", ",", "more", "relevant", "in", "the", "alendronate", "group", ".", "These", "findings", "were", "statistically", "significant", "for", "both", "subjective", "and", "objective", "MRI", "evaluations", ".", "CONCLUSIONS", "MRI", "shows", "higher", "sensitivity", "than", "clinical", "or", "audiometric", "assessment", "for", "detecting", "reduction", "in", "activity", "of", "otospongiosis", ".", "The", "objective", "MRI", "evaluation", "based", "on", "software", "analysis", "was", "the", "most", "accurate", "method", "of", "monitoring", "clinical", "treatment", "response", "in", "otospongiosis", "." ]

[ "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size", "Intervention_Control" ]

Magnetic resonance imaging, otospongiosis :, magnetic resonance imaging ( MRI ), Twenty - six, n = 42 ears, otosclerosis, computed tomography, placebo, sodium alendronate, sodium fluoride

70571_task2

Sentence: Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis : a pilot study . OBJECTIVES To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment . STUDY DESIGN Prospective , randomized , controlled , double-blind study . SETTING One single tertiary care institution in a large , cosmopolitan city . METHODS Twenty-six patients ( n = 42 ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled . If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement . Patients were divided into 3 groups and received treatment with placebo , sodium alendronate , or sodium fluoride for 6 months . After this period , clinical and audiometric evaluations and a second MRI were performed . Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner . RESULTS Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre- and posttreatment scans . The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group . These findings were statistically significant for both subjective and objective MRI evaluations . CONCLUSIONS MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .

[ "Magnetic", "resonance", "imaging", "in", "the", "evaluation", "of", "clinical", "treatment", "of", "otospongiosis", ":", "a", "pilot", "study", ".", "OBJECTIVES", "To", "evaluate", "the", "applicability", "of", "magnetic", "resonance", "imaging", "(", "MRI", ")", "as", "a", "method", "for", "monitoring", "the", "activity", "of", "otospongiotic", "lesions", "before", "and", "after", "clinical", "treatment", ".", "STUDY", "DESIGN", "Prospective", ",", "randomized", ",", "controlled", ",", "double", "-", "blind", "study", ".", "SETTING", "One", "single", "tertiary", "care", "institution", "in", "a", "large", ",", "cosmopolitan", "city", ".", "METHODS", "Twenty", "-", "six", "patients", "(", "n", "=", "42", "ears", ")", "with", "clinical", ",", "audiometric", ",", "and", "tomographic", "diagnosis", "of", "otosclerosis", "were", "enrolled", ".", "If", "computed", "tomography", "(", "CT", ")", "demonstrated", "active", "lesions", ",", "these", "patients", "underwent", "MRI", "to", "detect", "otospongiotic", "foci", ",", "seen", "as", "areas", "of", "gadolinium", "enhancement", ".", "Patients", "were", "divided", "into", "3", "groups", "and", "received", "treatment", "with", "placebo", ",", "sodium", "alendronate", ",", "or", "sodium", "fluoride", "for", "6", "months", ".", "After", "this", "period", ",", "clinical", "and", "audiometric", "evaluations", "and", "a", "second", "MRI", "were", "performed", ".", "Each", "MRI", "was", "evaluated", "by", "both", "a", "neuroradiologist", "and", "an", "otolaryngologist", "in", "a", "subjective", "(", "visual", ")", "and", "objective", "(", "using", "specific", "eFilm", "Workstation", "software", ")", "manner", ".", "RESULTS", "Otospongiosis", "was", "most", "predominantly", "identified", "in", "the", "region", "anterior", "to", "the", "oval", "window", ",", "and", "this", "site", "was", "reliable", "for", "comparing", "pre-", "and", "posttreatment", "scans", ".", "The", "patients", "in", "the", "alendronate", "and", "sodium", "fluoride", "groups", "had", "MRI", "findings", "that", "suggested", "a", "decrease", "in", "activity", "of", "otospongiotic", "lesions", ",", "more", "relevant", "in", "the", "alendronate", "group", ".", "These", "findings", "were", "statistically", "significant", "for", "both", "subjective", "and", "objective", "MRI", "evaluations", ".", "CONCLUSIONS", "MRI", "shows", "higher", "sensitivity", "than", "clinical", "or", "audiometric", "assessment", "for", "detecting", "reduction", "in", "activity", "of", "otospongiosis", ".", "The", "objective", "MRI", "evaluation", "based", "on", "software", "analysis", "was", "the", "most", "accurate", "method", "of", "monitoring", "clinical", "treatment", "response", "in", "otospongiosis", "." ]

[ "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Sample-size", "Intervention_Control" ]

LYSP100-associated nuclear domains is a cell_component, LANDs is a cell_component, subnuclear structures is a cell_component, PML nuclear bodies is a cell_component

25253_task0

Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_component

[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.

[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]

[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]

LYSP100-associated nuclear domains is a cell_component, LANDs is a cell_component, subnuclear structures is a cell_component, PML nuclear bodies is a cell_component

25253_task1

Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please typing these entity words according to sentence: LYSP100-associated nuclear domains, LANDs, subnuclear structures, PML nuclear bodies Options: cell_component

[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.

[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]

[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]

LYSP100-associated nuclear domains, LANDs, subnuclear structures, PML nuclear bodies

25253_task2

Sentence: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Instructions: please extract entity words from the input sentence

[ "B-cell_component", "I-cell_component", "I-cell_component", "O", "B-cell_component", "O", "O", "O", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "B-cell_component", "I-cell_component", "I-cell_component", "O" ]

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.

[ "LYSP100-associated", "nuclear", "domains", "(", "LANDs", "):", "description", "of", "a", "new", "class", "of", "subnuclear", "structures", "and", "their", "relationship", "to", "PML", "nuclear", "bodies", "." ]

[ "DNA_domain_or_region", "other_name", "protein_family_or_group", "cell_component", "protein_molecule", "cell_line", "DNA_family_or_group", "DNA_molecule", "protein_domain_or_region", "cell_type" ]