bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
myosin heavy chain is a Individual_protein, actin is a Individual_protein	591_task0	Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]	Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.	[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]	[ "Individual_protein" ]
myosin heavy chain is a Individual_protein, actin is a Individual_protein	591_task1	Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please typing these entity words according to sentence: myosin heavy chain, actin Options: Individual_protein	[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]	Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.	[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]	[ "Individual_protein" ]
myosin heavy chain, actin	591_task2	Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]	Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.	[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]	[ "Individual_protein" ]
novel gene is a DNA_family_or_group, 3q21 is a DNA_domain_or_region, ecotropic viral insertion site I is a DNA_domain_or_region, leukemia is an other_name	53235_task0	Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, DNA_domain_or_region, other_name	[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]	Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.	[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]	[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]
novel gene is a DNA_family_or_group, 3q21 is a DNA_domain_or_region, ecotropic viral insertion site I is a DNA_domain_or_region, leukemia is an other_name	53235_task1	Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please typing these entity words according to sentence: novel gene, 3q21, ecotropic viral insertion site I, leukemia Options: DNA_family_or_group, DNA_domain_or_region, other_name	[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]	Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.	[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]	[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]
novel gene, 3q21, ecotropic viral insertion site I, leukemia	53235_task2	Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]	Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.	[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]	[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]
Heparin plus dipyridamole is a Intervention_Pharmacological, childhood is a Participant_Age, hemolytic - uremic syndrome is a Participant_Condition, 58 is a Participant_Sample-size, infants and children is a Participant_Age, heparin and dipyridamole is a Intervention_Pharmacological, incidence of anuria is a Outcome_Physical, faster recovery from hypertension is a Outcome_Physical, incidence and severity of the histologic lesions is a Outcome_Physical, blood pressure is a Outcome_Physical, creatinine clearance values is a Outcome_Physical, benefit over symptomatic therapy is a Outcome_Other	75054_task0	Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Age, Participant_Sample-size, Outcome_Other	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .	[ "Heparin", "plus", "dipyridamole", "in", "childhood", "hemolytic", "-", "uremic", "syndrome", ":", "a", "prospective", ",", "randomized", "study", ".", "From", "1976", "to", "1985", ",", "a", "total", "of", "58", "infants", "and", "children", "with", "the", "hemolytic", "-", "uremic", "syndrome", "were", "randomly", "assigned", "to", "treatment", "either", "with", "heparin", "and", "dipyridamole", "or", "with", "supportive", "management", "only", ".", "In", "the", "treatment", "group", ",", "two", "patients", "died", "in", "the", "early", "weeks", "of", "the", "disease", ".", "Analysis", "of", "clinical", "and", "laboratory", "data", "showed", "no", "significant", "difference", "between", "either", "group", "of", "patients", "as", "to", "the", "evolution", "of", "their", "illness", "except", "for", "a", "significantly", "higher", "incidence", "of", "anuria", "and", "a", "significantly", "faster", "recovery", "from", "hypertension", "in", "the", "treated", "group", ".", "Renal", "biopsy", "studies", "showed", "no", "differences", "between", "the", "two", "groups", "in", "terms", "of", "incidence", "and", "severity", "of", "the", "histologic", "lesions", ".", "The", "long", "-", "term", "data", "on", "blood", "pressure", "and", "creatinine", "clearance", "values", "in", "the", "survivors", "were", "similar", "in", "both", "groups", ".", "This", "study", "indicates", "that", "treatment", "with", "heparin", "and", "dipyridamole", "has", "no", "benefit", "over", "symptomatic", "therapy", "alone", "in", "the", "typical", "form", "of", "childhood", "hemolytic", "-", "uremic", "syndrome", "." ]	[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]
Heparin plus dipyridamole is a Intervention_Pharmacological, childhood is a Participant_Age, hemolytic - uremic syndrome is a Participant_Condition, 58 is a Participant_Sample-size, infants and children is a Participant_Age, heparin and dipyridamole is a Intervention_Pharmacological, incidence of anuria is a Outcome_Physical, faster recovery from hypertension is a Outcome_Physical, incidence and severity of the histologic lesions is a Outcome_Physical, blood pressure is a Outcome_Physical, creatinine clearance values is a Outcome_Physical, benefit over symptomatic therapy is a Outcome_Other	75054_task1	Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please typing these entity words according to sentence: Heparin plus dipyridamole, childhood, hemolytic - uremic syndrome, 58, infants and children, heparin and dipyridamole, incidence of anuria, faster recovery from hypertension, incidence and severity of the histologic lesions, blood pressure, creatinine clearance values, benefit over symptomatic therapy Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Age, Participant_Sample-size, Outcome_Other	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .	[ "Heparin", "plus", "dipyridamole", "in", "childhood", "hemolytic", "-", "uremic", "syndrome", ":", "a", "prospective", ",", "randomized", "study", ".", "From", "1976", "to", "1985", ",", "a", "total", "of", "58", "infants", "and", "children", "with", "the", "hemolytic", "-", "uremic", "syndrome", "were", "randomly", "assigned", "to", "treatment", "either", "with", "heparin", "and", "dipyridamole", "or", "with", "supportive", "management", "only", ".", "In", "the", "treatment", "group", ",", "two", "patients", "died", "in", "the", "early", "weeks", "of", "the", "disease", ".", "Analysis", "of", "clinical", "and", "laboratory", "data", "showed", "no", "significant", "difference", "between", "either", "group", "of", "patients", "as", "to", "the", "evolution", "of", "their", "illness", "except", "for", "a", "significantly", "higher", "incidence", "of", "anuria", "and", "a", "significantly", "faster", "recovery", "from", "hypertension", "in", "the", "treated", "group", ".", "Renal", "biopsy", "studies", "showed", "no", "differences", "between", "the", "two", "groups", "in", "terms", "of", "incidence", "and", "severity", "of", "the", "histologic", "lesions", ".", "The", "long", "-", "term", "data", "on", "blood", "pressure", "and", "creatinine", "clearance", "values", "in", "the", "survivors", "were", "similar", "in", "both", "groups", ".", "This", "study", "indicates", "that", "treatment", "with", "heparin", "and", "dipyridamole", "has", "no", "benefit", "over", "symptomatic", "therapy", "alone", "in", "the", "typical", "form", "of", "childhood", "hemolytic", "-", "uremic", "syndrome", "." ]	[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]
Heparin plus dipyridamole, childhood, hemolytic - uremic syndrome, 58, infants and children, heparin and dipyridamole, incidence of anuria, faster recovery from hypertension, incidence and severity of the histologic lesions, blood pressure, creatinine clearance values, benefit over symptomatic therapy	75054_task2	Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .	[ "Heparin", "plus", "dipyridamole", "in", "childhood", "hemolytic", "-", "uremic", "syndrome", ":", "a", "prospective", ",", "randomized", "study", ".", "From", "1976", "to", "1985", ",", "a", "total", "of", "58", "infants", "and", "children", "with", "the", "hemolytic", "-", "uremic", "syndrome", "were", "randomly", "assigned", "to", "treatment", "either", "with", "heparin", "and", "dipyridamole", "or", "with", "supportive", "management", "only", ".", "In", "the", "treatment", "group", ",", "two", "patients", "died", "in", "the", "early", "weeks", "of", "the", "disease", ".", "Analysis", "of", "clinical", "and", "laboratory", "data", "showed", "no", "significant", "difference", "between", "either", "group", "of", "patients", "as", "to", "the", "evolution", "of", "their", "illness", "except", "for", "a", "significantly", "higher", "incidence", "of", "anuria", "and", "a", "significantly", "faster", "recovery", "from", "hypertension", "in", "the", "treated", "group", ".", "Renal", "biopsy", "studies", "showed", "no", "differences", "between", "the", "two", "groups", "in", "terms", "of", "incidence", "and", "severity", "of", "the", "histologic", "lesions", ".", "The", "long", "-", "term", "data", "on", "blood", "pressure", "and", "creatinine", "clearance", "values", "in", "the", "survivors", "were", "similar", "in", "both", "groups", ".", "This", "study", "indicates", "that", "treatment", "with", "heparin", "and", "dipyridamole", "has", "no", "benefit", "over", "symptomatic", "therapy", "alone", "in", "the", "typical", "form", "of", "childhood", "hemolytic", "-", "uremic", "syndrome", "." ]	[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]
neoplasia is a MORFOLOGIA_NEOPLASIA, tumor de células germinales ( TCG ) mixto is a MORFOLOGIA_NEOPLASIA, carcinoma embrionario is a MORFOLOGIA_NEOPLASIA, teratoma is a MORFOLOGIA_NEOPLASIA, tumor del seno endodérmico is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, lesión retroperitoneal is a MORFOLOGIA_NEOPLASIA, lesiones pulmonares is a MORFOLOGIA_NEOPLASIA, nódulos pulmonares is a MORFOLOGIA_NEOPLASIA, masa retroperitoneal is a MORFOLOGIA_NEOPLASIA, teratoma maduro is a MORFOLOGIA_NEOPLASIA, micronódulos pulmonares is a MORFOLOGIA_NEOPLASIA	109_task0	Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. 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Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.	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neoplasia is a MORFOLOGIA_NEOPLASIA, tumor de células germinales ( TCG ) mixto is a MORFOLOGIA_NEOPLASIA, carcinoma embrionario is a MORFOLOGIA_NEOPLASIA, teratoma is a MORFOLOGIA_NEOPLASIA, tumor del seno endodérmico is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, lesión retroperitoneal is a MORFOLOGIA_NEOPLASIA, lesiones pulmonares is a MORFOLOGIA_NEOPLASIA, nódulos pulmonares is a MORFOLOGIA_NEOPLASIA, masa retroperitoneal is a MORFOLOGIA_NEOPLASIA, teratoma maduro is a MORFOLOGIA_NEOPLASIA, micronódulos pulmonares is a MORFOLOGIA_NEOPLASIA	109_task1	Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. 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Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.	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neoplasia, tumor de células germinales ( TCG ) mixto, carcinoma embrionario, teratoma, tumor del seno endodérmico, nódulo pulmonar, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a, nódulo pulmonar, tumoral, lesión retroperitoneal, lesiones pulmonares, nódulos pulmonares, masa retroperitoneal, teratoma maduro, micronódulos pulmonares	109_task2	Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. 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"I-MORFOLOGIA_NEOPLASIA", "O", "O" ]	Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.	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IL-4 is a GENE-Y, CXCL-8 is a GENE-Y, E - selectin is a GENE-Y, VEGF is a GENE-Y, inducible nitric oxide synthase is a GENE-Y	17494951_task0	Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.	[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
IL-4 is a GENE-Y, CXCL-8 is a GENE-Y, E - selectin is a GENE-Y, VEGF is a GENE-Y, inducible nitric oxide synthase is a GENE-Y	17494951_task1	Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please typing these entity words according to sentence: IL-4, CXCL-8, E - selectin, VEGF, inducible nitric oxide synthase Options: GENE-Y	[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.	[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
IL-4, CXCL-8, E - selectin, VEGF, inducible nitric oxide synthase	17494951_task2	Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please extract entity words from the input sentence	[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.	[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
outpatient treatment is an umlsterm, detoxification is an umlsterm, psychiatric hospitals is an umlsterm, link is an umlsterm, detoxification is an umlsterm, inpatient treatment is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, motivation is an umlsterm, patients is an umlsterm, treatment is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, treatment is an umlsterm, goal is an umlsterm, treatment is an umlsterm, inpatients is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, period is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, behavior is an umlsterm, patients is an umlsterm, probability is an umlsterm	DerNervenarzt.70680574.eng.abstr_task0	Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .	[ "In", "addition", "to", "psychiatric", "outpatient", "treatment", ",", "the", "detoxification", "of", "alcoholics", "in", "psychiatric", "hospitals", "is", "an", "important", "link", "between", "medical", "detoxification", "and", "psychosocial", "inpatient", "treatment", "aiming", "at", "abstinence", ".", "Integrated", "models", "of", "inpatient", "detoxification", "and", "motivation", "therapy", "focus", "on", "improvement", "of", "the", "motivation", "of", "patients", "towards", "further", "treatment", "of", "their", "alcoholism", "and", "towards", "abstinence", ".", "In", "our", "study", "529", "alcoholics", "underwent", "such", "treatment", "lasting", "between", "2", "to", "3", "weeks", ".", "A", "total", "of", "469", "patients", "(", "89", "%", ")", "were", "followed", "up", "after", "8", "months", ";", "242", "alcoholics", "(", "52", "%", "of", "the", "follow", "-", "up", "sample", ";", "46", "%", "of", "the", "whole", "sample", ")", "achieved", "the", "treatment", "goal", "and", "started", "further", "treatment", ",", "mainly", "as", "inpatients", ".", "Fifty", "-", "four", "of", "these", "patients", "relapsed", "before", "they", "started", "further", "alcoholism", "treatment", ",", "but", "achieved", "abstinence", "afterwards", ";", "60", "(", "25", "%", ")", "of", "these", "242", "patients", "relapsed", "after", "the", "specific", "alcoholism", "therapy", ";", "227", "alcoholics", "did", "not", "start", "further", "treatment", "after", "the", "initial", "detoxification", "and", "motivation", "therapy", ".", "In", "this", "subpopulation", ",", "113", "(", "50", "%", ")", "relapsed", "during", "the", "follow", "-", "up", "period", ".", "Although", "this", "is", "not", "a", "controlled", "study", ",", "it", "can", "be", "concluded", "that", "integrated", "inpatient", "detoxification", "and", "motivation", "therapy", "has", "positive", "effects", "on", "the", "treatment", "behavior", "of", "alcoholic", "patients", "and", "enhances", "the", "probability", "of", "further", "abstinence", "." ]	[ "umlsterm" ]
outpatient treatment is an umlsterm, detoxification is an umlsterm, psychiatric hospitals is an umlsterm, link is an umlsterm, detoxification is an umlsterm, inpatient treatment is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, motivation is an umlsterm, patients is an umlsterm, treatment is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, treatment is an umlsterm, goal is an umlsterm, treatment is an umlsterm, inpatients is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, period is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, behavior is an umlsterm, patients is an umlsterm, probability is an umlsterm	DerNervenarzt.70680574.eng.abstr_task1	Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please typing these entity words according to sentence: outpatient treatment, detoxification, psychiatric hospitals, link, detoxification, inpatient treatment, inpatient, detoxification, motivation, therapy, motivation, patients, treatment, alcoholism, treatment, patients, treatment, goal, treatment, inpatients, patients, alcoholism, treatment, patients, alcoholism, therapy, treatment, detoxification, motivation, therapy, period, inpatient, detoxification, motivation, therapy, treatment, behavior, patients, probability Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .	[ "In", "addition", "to", "psychiatric", "outpatient", "treatment", ",", "the", "detoxification", "of", "alcoholics", "in", "psychiatric", "hospitals", "is", "an", "important", "link", "between", "medical", "detoxification", "and", "psychosocial", "inpatient", "treatment", "aiming", "at", "abstinence", ".", "Integrated", "models", "of", "inpatient", "detoxification", "and", "motivation", "therapy", "focus", "on", "improvement", "of", "the", "motivation", "of", "patients", "towards", "further", "treatment", "of", "their", "alcoholism", "and", "towards", "abstinence", ".", "In", "our", "study", "529", "alcoholics", "underwent", "such", "treatment", "lasting", "between", "2", "to", "3", "weeks", ".", "A", "total", "of", "469", "patients", "(", "89", "%", ")", "were", "followed", "up", "after", "8", "months", ";", "242", "alcoholics", "(", "52", "%", "of", "the", "follow", "-", "up", "sample", ";", "46", "%", "of", "the", "whole", "sample", ")", "achieved", "the", "treatment", "goal", "and", "started", "further", "treatment", ",", "mainly", "as", "inpatients", ".", "Fifty", "-", "four", "of", "these", "patients", "relapsed", "before", "they", "started", "further", "alcoholism", "treatment", ",", "but", "achieved", "abstinence", "afterwards", ";", "60", "(", "25", "%", ")", "of", "these", "242", "patients", "relapsed", "after", "the", "specific", "alcoholism", "therapy", ";", "227", "alcoholics", "did", "not", "start", "further", "treatment", "after", "the", "initial", "detoxification", "and", "motivation", "therapy", ".", "In", "this", "subpopulation", ",", "113", "(", "50", "%", ")", "relapsed", "during", "the", "follow", "-", "up", "period", ".", "Although", "this", "is", "not", "a", "controlled", "study", ",", "it", "can", "be", "concluded", "that", "integrated", "inpatient", "detoxification", "and", "motivation", "therapy", "has", "positive", "effects", "on", "the", "treatment", "behavior", "of", "alcoholic", "patients", "and", "enhances", "the", "probability", "of", "further", "abstinence", "." ]	[ "umlsterm" ]
outpatient treatment, detoxification, psychiatric hospitals, link, detoxification, inpatient treatment, inpatient, detoxification, motivation, therapy, motivation, patients, treatment, alcoholism, treatment, patients, treatment, goal, treatment, inpatients, patients, alcoholism, treatment, patients, alcoholism, therapy, treatment, detoxification, motivation, therapy, period, inpatient, detoxification, motivation, therapy, treatment, behavior, patients, probability	DerNervenarzt.70680574.eng.abstr_task2	Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .	[ "In", "addition", "to", "psychiatric", "outpatient", "treatment", ",", "the", "detoxification", "of", "alcoholics", "in", "psychiatric", "hospitals", "is", "an", "important", "link", "between", "medical", "detoxification", "and", "psychosocial", "inpatient", "treatment", "aiming", "at", "abstinence", ".", "Integrated", "models", "of", "inpatient", "detoxification", "and", "motivation", "therapy", "focus", "on", "improvement", "of", "the", "motivation", "of", "patients", "towards", "further", "treatment", "of", "their", "alcoholism", "and", "towards", "abstinence", ".", "In", "our", "study", "529", "alcoholics", "underwent", "such", "treatment", "lasting", "between", "2", "to", "3", "weeks", ".", "A", "total", "of", "469", "patients", "(", "89", "%", ")", "were", "followed", "up", "after", "8", "months", ";", "242", "alcoholics", "(", "52", "%", "of", "the", "follow", "-", "up", "sample", ";", "46", "%", "of", "the", "whole", "sample", ")", "achieved", "the", "treatment", "goal", "and", "started", "further", "treatment", ",", "mainly", "as", "inpatients", ".", "Fifty", "-", "four", "of", "these", "patients", "relapsed", "before", "they", "started", "further", "alcoholism", "treatment", ",", "but", "achieved", "abstinence", "afterwards", ";", "60", "(", "25", "%", ")", "of", "these", "242", "patients", "relapsed", "after", "the", "specific", "alcoholism", "therapy", ";", "227", "alcoholics", "did", "not", "start", "further", "treatment", "after", "the", "initial", "detoxification", "and", "motivation", "therapy", ".", "In", "this", "subpopulation", ",", "113", "(", "50", "%", ")", "relapsed", "during", "the", "follow", "-", "up", "period", ".", "Although", "this", "is", "not", "a", "controlled", "study", ",", "it", "can", "be", "concluded", "that", "integrated", "inpatient", "detoxification", "and", "motivation", "therapy", "has", "positive", "effects", "on", "the", "treatment", "behavior", "of", "alcoholic", "patients", "and", "enhances", "the", "probability", "of", "further", "abstinence", "." ]	[ "umlsterm" ]
actin is a Individual_protein, myosin heavy chain is a Individual_protein	218_task0	Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]	Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.	[ "Cytoplasmic", "staining", "included", "stress", "fibers", "that", "colocalized", "with", "actin", ",", "probably", "as", "a", "consequence", "of", "the", "myosin", "heavy", "chain", "component", "of", "the", "fusion", "protein", "." ]	[ "Individual_protein" ]
actin is a Individual_protein, myosin heavy chain is a Individual_protein	218_task1	Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please typing these entity words according to sentence: actin, myosin heavy chain Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]	Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.	[ "Cytoplasmic", "staining", "included", "stress", "fibers", "that", "colocalized", "with", "actin", ",", "probably", "as", "a", "consequence", "of", "the", "myosin", "heavy", "chain", "component", "of", "the", "fusion", "protein", "." ]	[ "Individual_protein" ]
actin, myosin heavy chain	218_task2	Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]	Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.	[ "Cytoplasmic", "staining", "included", "stress", "fibers", "that", "colocalized", "with", "actin", ",", "probably", "as", "a", "consequence", "of", "the", "myosin", "heavy", "chain", "component", "of", "the", "fusion", "protein", "." ]	[ "Individual_protein" ]
Children is an umlsterm, occurrence is an umlsterm, hypothermia is an umlsterm, temperature is an umlsterm, general anaesthesia is an umlsterm, regulation is an umlsterm, adults is an umlsterm, heating is an umlsterm, devices is an umlsterm, children is an umlsterm, surgery is an umlsterm	DerAnaesthesist.80470475.eng.abstr_task0	Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .	[ "Children", "are", "very", "sensible", "to", "the", "occurrence", "of", "intraoperative", "hypothermia", "(", "HT", ")", "(", "core", "temperature", "=", "36", ".", "0", "C", ")", "during", "general", "anaesthesia", "because", "their", "regulation", "capacity", "is", "less", "effective", "than", "in", "adults", "and", "due", "to", "a", "large", "skin", "-", "surface", "area", "compared", "with", "their", "body", "mass", ".", "We", "compared", "the", "efficacy", "of", "different", "heating", "devices", "to", "prevent", "HT", "in", "children", "during", "surgery", "." ]	[ "umlsterm" ]
Children is an umlsterm, occurrence is an umlsterm, hypothermia is an umlsterm, temperature is an umlsterm, general anaesthesia is an umlsterm, regulation is an umlsterm, adults is an umlsterm, heating is an umlsterm, devices is an umlsterm, children is an umlsterm, surgery is an umlsterm	DerAnaesthesist.80470475.eng.abstr_task1	Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please typing these entity words according to sentence: Children, occurrence, hypothermia, temperature, general anaesthesia, regulation, adults, heating, devices, children, surgery Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .	[ "Children", "are", "very", "sensible", "to", "the", "occurrence", "of", "intraoperative", "hypothermia", "(", "HT", ")", "(", "core", "temperature", "=", "36", ".", "0", "C", ")", "during", "general", "anaesthesia", "because", "their", "regulation", "capacity", "is", "less", "effective", "than", "in", "adults", "and", "due", "to", "a", "large", "skin", "-", "surface", "area", "compared", "with", "their", "body", "mass", ".", "We", "compared", "the", "efficacy", "of", "different", "heating", "devices", "to", "prevent", "HT", "in", "children", "during", "surgery", "." ]	[ "umlsterm" ]
Children, occurrence, hypothermia, temperature, general anaesthesia, regulation, adults, heating, devices, children, surgery	DerAnaesthesist.80470475.eng.abstr_task2	Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .	[ "Children", "are", "very", "sensible", "to", "the", "occurrence", "of", "intraoperative", "hypothermia", "(", "HT", ")", "(", "core", "temperature", "=", "36", ".", "0", "C", ")", "during", "general", "anaesthesia", "because", "their", "regulation", "capacity", "is", "less", "effective", "than", "in", "adults", "and", "due", "to", "a", "large", "skin", "-", "surface", "area", "compared", "with", "their", "body", "mass", ".", "We", "compared", "the", "efficacy", "of", "different", "heating", "devices", "to", "prevent", "HT", "in", "children", "during", "surgery", "." ]	[ "umlsterm" ]
Early educational intervention is a Intervention_Educational, very low birth weight infants : is a Participant_Condition, Infant Health and Development Program . is a Intervention_Educational, early educational intervention is a Intervention_Educational, very low birth weight ( < or = 1500 gm ) infants . is a Participant_Condition, follow - up only is a Intervention_Control, intensive pediatric and developmental surveillance . is a Intervention_Educational, received home visits and center - based educational interventions is a Intervention_Educational, Cognitive development ( Stanford - Binet Intelligence Scale ) is a Outcome_Mental, behavioral competence ( Achebach Child Behavior Checklist ) is a Outcome_Mental, health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) is a Outcome_Physical, Cognitive development scores is a Outcome_Physical, neonatal morbidity is a Outcome_Physical, behavior , serious morbidity , functional status , or health rating is a Outcome_Physical, lower behavior problem scores is a Outcome_Physical, rates of less serious morbidity . is a Outcome_Physical	81866_task0	Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Participant_Condition, Intervention_Educational, Outcome_Physical, Outcome_Mental	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .	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Early educational intervention is a Intervention_Educational, very low birth weight infants : is a Participant_Condition, Infant Health and Development Program . is a Intervention_Educational, early educational intervention is a Intervention_Educational, very low birth weight ( < or = 1500 gm ) infants . is a Participant_Condition, follow - up only is a Intervention_Control, intensive pediatric and developmental surveillance . is a Intervention_Educational, received home visits and center - based educational interventions is a Intervention_Educational, Cognitive development ( Stanford - Binet Intelligence Scale ) is a Outcome_Mental, behavioral competence ( Achebach Child Behavior Checklist ) is a Outcome_Mental, health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) is a Outcome_Physical, Cognitive development scores is a Outcome_Physical, neonatal morbidity is a Outcome_Physical, behavior , serious morbidity , functional status , or health rating is a Outcome_Physical, lower behavior problem scores is a Outcome_Physical, rates of less serious morbidity . is a Outcome_Physical	81866_task1	Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please typing these entity words according to sentence: Early educational intervention, very low birth weight infants :, Infant Health and Development Program ., early educational intervention, very low birth weight ( < or = 1500 gm ) infants ., follow - up only, intensive pediatric and developmental surveillance ., received home visits and center - based educational interventions, Cognitive development ( Stanford - Binet Intelligence Scale ), behavioral competence ( Achebach Child Behavior Checklist ), health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ), Cognitive development scores, neonatal morbidity, behavior , serious morbidity , functional status , or health rating, lower behavior problem scores, rates of less serious morbidity . Options: Intervention_Control, Participant_Condition, Intervention_Educational, Outcome_Physical, Outcome_Mental	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .	[ "Early", "educational", "intervention", "for", "very", "low", "birth", "weight", "infants", ":", "results", "from", "the", "Infant", "Health", "and", "Development", "Program", ".", "OBJECTIVE", "To", "examine", "the", "effect", "of", "early", "educational", "intervention", "after", "discharge", "from", "the", "hospital", "on", "the", "health", "and", "developmental", "status", "of", "very", "low", "birth", "weight", "(", "<", "or", "=", "1500", "gm", ")", "infants", ".", "DESIGN", "Randomized", ",", "controlled", "trial", ",", "with", "post", "hoc", "analysis", ".", "SETTING", "Eight", "sites", ",", "heterogeneous", "for", "sociodemographic", "and", "health", "care", "use", ".", "PARTICIPANTS", "Infants", "(", "N", "=", "280", ")", "born", "weighing", "<", "or", "=", "1500", "gm", "and", "selected", "for", "the", "Infant", "Health", "and", "Development", "Program", ".", "Eligibility", "was", "limited", "primarily", "by", "geographic", "distance", "from", "the", "day", "care", "center", ".", "One", "third", "were", "randomly", "assigned", "to", "the", "intervention", "(", "INT", ")", "group", "and", "two", "thirds", "to", "follow", "-", "up", "only", ".", "INTERVENTIONS", "All", "children", "received", "intensive", "pediatric", "and", "developmental", "surveillance", ".", "The", "INT", "group", "received", "home", "visits", "and", "center", "-", "based", "educational", "interventions", "until", "36", "months", "of", "age", "(", "corrected", "for", "gestational", "age", "when", "final", "assessments", "were", "completed", ")", ".", "OUTCOMES", "Cognitive", "development", "(", "Stanford", "-", "Binet", "Intelligence", "Scale", ")", ",", "behavioral", "competence", "(", "Achebach", "Child", "Behavior", "Checklist", ")", ",", "and", "health", "status", "(", "indexes", "summarizing", "reported", "morbidity", ",", "the", "Functional", "Status", "II", "(", "R", ")", "Scale", ",", "and", "General", "Health", "Ratings", "Index", ")", ".", "RESULTS", "Cognitive", "development", "scores", "were", "7.2", "points", "higher", "(", "p", "=", "0.002", ")", "in", "the", "INT", "group", ",", "after", "adjustment", "for", "baseline", "differences", "in", "site", ",", "sociodemographic", "characteristics", ",", "and", "neonatal", "morbidity", ",", "and", "were", "9.4", "points", "higher", "(", "p", "<", "0.0003", ")", "when", "the", "29", "children", "with", "significant", "cerebral", "palsy", "were", "removed", ".", "No", "differences", "in", "behavior", ",", "serious", "morbidity", ",", "functional", "status", ",", "or", "health", "rating", "were", "found", "overall", ".", "The", "infants", "in", "the", "INT", "group", "who", "weighted", "<", "or", "=", "1000", "gm", "at", "birth", "had", "significantly", "lower", "behavior", "problem", "scores", "but", "no", "differences", "on", "other", "outcomes", ".", "All", "children", "in", "the", "INT", "group", "had", "slightly", "higher", "rates", "of", "less", "serious", "morbidity", ".", "CONCLUSION", "The", "advantage", "conferred", "by", "being", "in", "the", "INT", "group", ",", "as", "previously", "reported", "for", "heavier", "infants", ",", "extends", "to", "very", "low", "birth", "weight", "children", ",", "supporting", "the", "use", "of", "early", "intervention", "in", "this", "group", "." ]	[ "Outcome_Physical", "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Control" ]
Early educational intervention, very low birth weight infants :, Infant Health and Development Program ., early educational intervention, very low birth weight ( < or = 1500 gm ) infants ., follow - up only, intensive pediatric and developmental surveillance ., received home visits and center - based educational interventions, Cognitive development ( Stanford - Binet Intelligence Scale ), behavioral competence ( Achebach Child Behavior Checklist ), health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ), Cognitive development scores, neonatal morbidity, behavior , serious morbidity , functional status , or health rating, lower behavior problem scores, rates of less serious morbidity .	81866_task2	Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .	[ "Early", "educational", "intervention", "for", "very", "low", "birth", "weight", "infants", ":", "results", "from", "the", "Infant", "Health", "and", "Development", "Program", ".", "OBJECTIVE", "To", "examine", "the", "effect", "of", "early", "educational", "intervention", "after", "discharge", "from", "the", "hospital", "on", "the", "health", "and", "developmental", "status", "of", "very", "low", "birth", "weight", "(", "<", "or", "=", "1500", "gm", ")", "infants", ".", "DESIGN", "Randomized", ",", "controlled", "trial", ",", "with", "post", "hoc", "analysis", ".", "SETTING", "Eight", "sites", ",", "heterogeneous", "for", "sociodemographic", "and", "health", "care", "use", ".", "PARTICIPANTS", "Infants", "(", "N", "=", "280", ")", "born", "weighing", "<", "or", "=", "1500", "gm", "and", "selected", "for", "the", "Infant", "Health", "and", "Development", "Program", ".", "Eligibility", "was", "limited", "primarily", "by", "geographic", "distance", "from", "the", "day", "care", "center", ".", "One", "third", "were", "randomly", "assigned", "to", "the", "intervention", "(", "INT", ")", "group", "and", "two", "thirds", "to", "follow", "-", "up", "only", ".", "INTERVENTIONS", "All", "children", "received", "intensive", "pediatric", "and", "developmental", "surveillance", ".", "The", "INT", "group", "received", "home", "visits", "and", "center", "-", "based", "educational", "interventions", "until", "36", "months", "of", "age", "(", "corrected", "for", "gestational", "age", "when", "final", "assessments", "were", "completed", ")", ".", "OUTCOMES", "Cognitive", "development", "(", "Stanford", "-", "Binet", "Intelligence", "Scale", ")", ",", "behavioral", "competence", "(", "Achebach", "Child", "Behavior", "Checklist", ")", ",", "and", "health", "status", "(", "indexes", "summarizing", "reported", "morbidity", ",", "the", "Functional", "Status", "II", "(", "R", ")", "Scale", ",", "and", "General", "Health", "Ratings", "Index", ")", ".", "RESULTS", "Cognitive", "development", "scores", "were", "7.2", "points", "higher", "(", "p", "=", "0.002", ")", "in", "the", "INT", "group", ",", "after", "adjustment", "for", "baseline", "differences", "in", "site", ",", "sociodemographic", "characteristics", ",", "and", "neonatal", "morbidity", ",", "and", "were", "9.4", "points", "higher", "(", "p", "<", "0.0003", ")", "when", "the", "29", "children", "with", "significant", "cerebral", "palsy", "were", "removed", ".", "No", "differences", "in", "behavior", ",", "serious", "morbidity", ",", "functional", "status", ",", "or", "health", "rating", "were", "found", "overall", ".", "The", "infants", "in", "the", "INT", "group", "who", "weighted", "<", "or", "=", "1000", "gm", "at", "birth", "had", "significantly", "lower", "behavior", "problem", "scores", "but", "no", "differences", "on", "other", "outcomes", ".", "All", "children", "in", "the", "INT", "group", "had", "slightly", "higher", "rates", "of", "less", "serious", "morbidity", ".", "CONCLUSION", "The", "advantage", "conferred", "by", "being", "in", "the", "INT", "group", ",", "as", "previously", "reported", "for", "heavier", "infants", ",", "extends", "to", "very", "low", "birth", "weight", "children", ",", "supporting", "the", "use", "of", "early", "intervention", "in", "this", "group", "." ]	[ "Outcome_Physical", "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Control" ]
rotundic acid is a CHEMICAL	23558236_task0	Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]	Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.	[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]	[ "CHEMICAL", "GENE-Y" ]
rotundic acid is a CHEMICAL	23558236_task1	Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please typing these entity words according to sentence: rotundic acid Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]	Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.	[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]	[ "CHEMICAL", "GENE-Y" ]
rotundic acid	23558236_task2	Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]	Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.	[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]	[ "CHEMICAL", "GENE-Y" ]
age is a Person, < 45 or > 80 is a Value, allergies is a Condition, medications is a Drug, used in the study is a Qualifier, history is a Observation, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse is a Scope, definite is a Qualifier, radiographic evidence is a Mood, osteoarthritis is a Condition, glenohumeral joint is a Qualifier, inflammatory arthritis is a Condition, rheumatoid arthritis is a Condition, history is a Observation, acute trauma is a Condition, systemic conditions is a Condition, associated with chronic pain is a Qualifier, history is a Observation, infection is a Condition, inability to understand the questionnaires is a Observation	NCT02992028_exc_task0	Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Observation, Scope, Mood, Drug	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]	age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires	[ "age", "<", "45", "or", ">", "80", "\n", "allergies", "to", "medications", "used", "in", "the", "study", "\n", "history", "of", "renal", "diseases", ",", "a", "coagulation", "abnormality", ",", "a", "hepatic", "disease", ",", "or", "drug", "abuse", "\n", "definite", "radiographic", "evidence", "of", "osteoarthritis", "of", "the", "glenohumeral", "joint", "\n", "inflammatory", "arthritis", "including", "rheumatoid", "arthritis", "\n", "a", "history", "of", "acute", "trauma", "\n", "systemic", "conditions", "associated", "with", "chronic", "pain", "\n", "a", "history", "of", "infection", "\n", "an", "inability", "to", "understand", "the", "questionnaires", "\n" ]	[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]
age is a Person, < 45 or > 80 is a Value, allergies is a Condition, medications is a Drug, used in the study is a Qualifier, history is a Observation, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse is a Scope, definite is a Qualifier, radiographic evidence is a Mood, osteoarthritis is a Condition, glenohumeral joint is a Qualifier, inflammatory arthritis is a Condition, rheumatoid arthritis is a Condition, history is a Observation, acute trauma is a Condition, systemic conditions is a Condition, associated with chronic pain is a Qualifier, history is a Observation, infection is a Condition, inability to understand the questionnaires is a Observation	NCT02992028_exc_task1	Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please typing these entity words according to sentence: age, < 45 or > 80, allergies, medications, used in the study, history, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse, definite, radiographic evidence, osteoarthritis, glenohumeral joint, inflammatory arthritis, rheumatoid arthritis, history, acute trauma, systemic conditions, associated with chronic pain, history, infection, inability to understand the questionnaires Options: Condition, Qualifier, Value, Person, Observation, Scope, Mood, Drug	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]	age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires	[ "age", "<", "45", "or", ">", "80", "\n", "allergies", "to", "medications", "used", "in", "the", "study", "\n", "history", "of", "renal", "diseases", ",", "a", "coagulation", "abnormality", ",", "a", "hepatic", "disease", ",", "or", "drug", "abuse", "\n", "definite", "radiographic", "evidence", "of", "osteoarthritis", "of", "the", "glenohumeral", "joint", "\n", "inflammatory", "arthritis", "including", "rheumatoid", "arthritis", "\n", "a", "history", "of", "acute", "trauma", "\n", "systemic", "conditions", "associated", "with", "chronic", "pain", "\n", "a", "history", "of", "infection", "\n", "an", "inability", "to", "understand", "the", "questionnaires", "\n" ]	[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]
age, < 45 or > 80, allergies, medications, used in the study, history, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse, definite, radiographic evidence, osteoarthritis, glenohumeral joint, inflammatory arthritis, rheumatoid arthritis, history, acute trauma, systemic conditions, associated with chronic pain, history, infection, inability to understand the questionnaires	NCT02992028_exc_task2	Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please extract entity words from the input sentence	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]	age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires	[ "age", "<", "45", "or", ">", "80", "\n", "allergies", "to", "medications", "used", "in", "the", "study", "\n", "history", "of", "renal", "diseases", ",", "a", "coagulation", "abnormality", ",", "a", "hepatic", "disease", ",", "or", "drug", "abuse", "\n", "definite", "radiographic", "evidence", "of", "osteoarthritis", "of", "the", "glenohumeral", "joint", "\n", "inflammatory", "arthritis", "including", "rheumatoid", "arthritis", "\n", "a", "history", "of", "acute", "trauma", "\n", "systemic", "conditions", "associated", "with", "chronic", "pain", "\n", "a", "history", "of", "infection", "\n", "an", "inability", "to", "understand", "the", "questionnaires", "\n" ]	[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]
non - cystic fibrosis bronchiectasis is a Condition, high - resolution CT is a Procedure, sensitive is a Condition, amikacin is a Drug, Acute exacerbation of bronchiectasis is a Condition	NCT02509091_inc_task0	Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Procedure, Drug	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.	[ "Age=18", "years", "and", "=", "80", "years", ";", "\n", "Patients", "with", "non", "-", "cystic", "fibrosis", "bronchiectasis", "diagnosed", "by", "high", "-", "resolution", "CT", ";", "\n", "Are", "sensitive", "to", "amikacin", ";", "\n", "Acute", "exacerbation", "of", "bronchiectasis", ";", "\n", "Capable", "of", "the", "completion", "of", "bronchoscopy", ",", "alveolar", "lavage", ",", "pulmonary", "function", "testing", "etc", ";", "\n", "Willing", "to", "join", "in", "and", "sign", "the", "informed", "consent", "form", ".", "\n" ]	[ "Condition", "Value", "Procedure", "Drug", "Person" ]
non - cystic fibrosis bronchiectasis is a Condition, high - resolution CT is a Procedure, sensitive is a Condition, amikacin is a Drug, Acute exacerbation of bronchiectasis is a Condition	NCT02509091_inc_task1	Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please typing these entity words according to sentence: non - cystic fibrosis bronchiectasis, high - resolution CT, sensitive, amikacin, Acute exacerbation of bronchiectasis Options: Condition, Procedure, Drug	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.	[ "Age=18", "years", "and", "=", "80", "years", ";", "\n", "Patients", "with", "non", "-", "cystic", "fibrosis", "bronchiectasis", "diagnosed", "by", "high", "-", "resolution", "CT", ";", "\n", "Are", "sensitive", "to", "amikacin", ";", "\n", "Acute", "exacerbation", "of", "bronchiectasis", ";", "\n", "Capable", "of", "the", "completion", "of", "bronchoscopy", ",", "alveolar", "lavage", ",", "pulmonary", "function", "testing", "etc", ";", "\n", "Willing", "to", "join", "in", "and", "sign", "the", "informed", "consent", "form", ".", "\n" ]	[ "Condition", "Value", "Procedure", "Drug", "Person" ]
non - cystic fibrosis bronchiectasis, high - resolution CT, sensitive, amikacin, Acute exacerbation of bronchiectasis	NCT02509091_inc_task2	Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.	[ "Age=18", "years", "and", "=", "80", "years", ";", "\n", "Patients", "with", "non", "-", "cystic", "fibrosis", "bronchiectasis", "diagnosed", "by", "high", "-", "resolution", "CT", ";", "\n", "Are", "sensitive", "to", "amikacin", ";", "\n", "Acute", "exacerbation", "of", "bronchiectasis", ";", "\n", "Capable", "of", "the", "completion", "of", "bronchoscopy", ",", "alveolar", "lavage", ",", "pulmonary", "function", "testing", "etc", ";", "\n", "Willing", "to", "join", "in", "and", "sign", "the", "informed", "consent", "form", ".", "\n" ]	[ "Condition", "Value", "Procedure", "Drug", "Person" ]
Interferon - gamma is a protein_molecule, antiviral activity is an other_name, interferon - stimulated genes is a DNA_family_or_group, interferon - alpha in U937 cells is a cell_line	88913_task0	Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, other_name, cell_line, protein_molecule	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]	Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.	[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]	[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]
Interferon - gamma is a protein_molecule, antiviral activity is an other_name, interferon - stimulated genes is a DNA_family_or_group, interferon - alpha in U937 cells is a cell_line	88913_task1	Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please typing these entity words according to sentence: Interferon - gamma, antiviral activity, interferon - stimulated genes, interferon - alpha in U937 cells Options: DNA_family_or_group, other_name, cell_line, protein_molecule	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]	Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.	[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]	[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]
Interferon - gamma, antiviral activity, interferon - stimulated genes, interferon - alpha in U937 cells	88913_task2	Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please extract entity words from the input sentence	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]	Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.	[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]	[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]
Radiotherapie is an umlsterm, malignen Melanom is an umlsterm, Prognosefaktoren is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Patienten is an umlsterm, Histologie is an umlsterm, Melanoms is an umlsterm, Histologie is an umlsterm, Patienten is an umlsterm, Rezidivtumoren is an umlsterm, Tumorrest is an umlsterm, Patienten is an umlsterm, Lymphknoten- is an umlsterm, Fernmetastasen is an umlsterm, Erstdiagnose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Analyse is an umlsterm, Kopf - Hals - Bereich is an umlsterm, multivariater Analyse is an umlsterm, Prognosefaktor is an umlsterm, Tumorkontrolle is an umlsterm, Tumorkontrolle is an umlsterm	DerHautarzt.90500572.ger.abstr_task0	Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . 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Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .	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Radiotherapie is an umlsterm, malignen Melanom is an umlsterm, Prognosefaktoren is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Patienten is an umlsterm, Histologie is an umlsterm, Melanoms is an umlsterm, Histologie is an umlsterm, Patienten is an umlsterm, Rezidivtumoren is an umlsterm, Tumorrest is an umlsterm, Patienten is an umlsterm, Lymphknoten- is an umlsterm, Fernmetastasen is an umlsterm, Erstdiagnose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Analyse is an umlsterm, Kopf - Hals - Bereich is an umlsterm, multivariater Analyse is an umlsterm, Prognosefaktor is an umlsterm, Tumorkontrolle is an umlsterm, Tumorkontrolle is an umlsterm	DerHautarzt.90500572.ger.abstr_task1	Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . Instructions: please typing these entity words according to sentence: Radiotherapie, malignen Melanom, Prognosefaktoren, Patienten, Frauen, Maenner, Patienten, Histologie, Melanoms, Histologie, Patienten, Rezidivtumoren, Tumorrest, Patienten, Lymphknoten-, Fernmetastasen, Erstdiagnose, Patienten, Patienten, Patienten, Patienten, Patienten, Analyse, Kopf - Hals - Bereich, multivariater Analyse, Prognosefaktor, Tumorkontrolle, Tumorkontrolle Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .	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Radiotherapie, malignen Melanom, Prognosefaktoren, Patienten, Frauen, Maenner, Patienten, Histologie, Melanoms, Histologie, Patienten, Rezidivtumoren, Tumorrest, Patienten, Lymphknoten-, Fernmetastasen, Erstdiagnose, Patienten, Patienten, Patienten, Patienten, Patienten, Analyse, Kopf - Hals - Bereich, multivariater Analyse, Prognosefaktor, Tumorkontrolle, Tumorkontrolle	DerHautarzt.90500572.ger.abstr_task2	Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . 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Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .	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Stimulationsimpedanz is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwert is an umlsterm, Langzeitverlauf is an umlsterm, Patienten is an umlsterm, Impedanzaenderungen is an umlsterm, Implantations- is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwerte is an umlsterm, Implantationswert is an umlsterm, Impedanz is an umlsterm, Impedanzwerten is an umlsterm, Impedanzwerte is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Impedanzwerten is an umlsterm, Patienten is an umlsterm, Impedanzen is an umlsterm, Stimulanzimpedanz is an umlsterm, Patienten is an umlsterm, Stimulationsimpedanz is an umlsterm	ZfuerKardiologie.80870022.ger.abstr_task0	Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . 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Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .	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Stimulationsimpedanz is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwert is an umlsterm, Langzeitverlauf is an umlsterm, Patienten is an umlsterm, Impedanzaenderungen is an umlsterm, Implantations- is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwerte is an umlsterm, Implantationswert is an umlsterm, Impedanz is an umlsterm, Impedanzwerten is an umlsterm, Impedanzwerte is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Impedanzwerten is an umlsterm, Patienten is an umlsterm, Impedanzen is an umlsterm, Stimulanzimpedanz is an umlsterm, Patienten is an umlsterm, Stimulationsimpedanz is an umlsterm	ZfuerKardiologie.80870022.ger.abstr_task1	Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . Instructions: please typing these entity words according to sentence: Stimulationsimpedanz, Impedanzwerte, Impedanzwert, Langzeitverlauf, Patienten, Impedanzaenderungen, Implantations-, Impedanzwerte, Impedanzwerte, Implantationswert, Impedanz, Impedanzwerten, Impedanzwerte, Patienten, Patienten, Impedanzwerten, Patienten, Impedanzen, Stimulanzimpedanz, Patienten, Stimulationsimpedanz Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .	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Stimulationsimpedanz, Impedanzwerte, Impedanzwert, Langzeitverlauf, Patienten, Impedanzaenderungen, Implantations-, Impedanzwerte, Impedanzwerte, Implantationswert, Impedanz, Impedanzwerten, Impedanzwerte, Patienten, Patienten, Impedanzwerten, Patienten, Impedanzen, Stimulanzimpedanz, Patienten, Stimulationsimpedanz	ZfuerKardiologie.80870022.ger.abstr_task2	Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .	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volunteers is a Participant_Sample-size, prospective Le Fort I osteotomy is a Participant_Condition, multi - media tablet device delivering both graphic and verbal information is a Intervention_Educational, audio device delivering essentially the same information in verbal form only is a Intervention_Educational, efficiencies is a Outcome_Other, ability to recall the information is a Outcome_Mental	63913_task0	Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .	[ "Evaluation", "of", "an", "interactive", "multi", "-", "media", "device", "for", "delivering", "information", "on", "Le", "Fort", "I", "osteotomy", ".", "This", "study", "was", "carried", "out", "on", "volunteers", "to", "evaluate", "a", "newly", "developed", "interactive", "software", "package", "aimed", "at", "informing", "prospective", "Le", "Fort", "I", "osteotomy", "patients", "regarding", "the", "surgical", "technique", "and", "possible", "complications", ".", "The", "aim", "of", "the", "study", "was", "to", "compare", "two", "methods", "of", "information", "delivery", ";", "a", "multi", "-", "media", "tablet", "device", "delivering", "both", "graphic", "and", "verbal", "information", ",", "and", "an", "audio", "device", "delivering", "essentially", "the", "same", "information", "in", "verbal", "form", "only", ".", "The", "null", "hypothesis", "was", "that", "there", "would", "be", "no", "difference", "between", "the", "efficiencies", "of", "the", "two", "methods", ".", "The", "subjects", "'", "ability", "to", "recall", "the", "information", "delivered", "by", "both", "devices", "was", "assessed", "using", "a", "questionnaire", ".", "The", "tablet", "device", "participants", "scored", "an", "average", "of", "15.48", "points", ",", "while", "the", "audio", "device", "participants", "scored", "an", "average", "of", "268", "points", ".", "The", "difference", "was", "statistically", "significant", "(", "p", "<", "0.001", ")", ",", "suggesting", "that", "the", "multi", "-", "media", "tablet", "device", "was", "more", "effective", "method", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
volunteers is a Participant_Sample-size, prospective Le Fort I osteotomy is a Participant_Condition, multi - media tablet device delivering both graphic and verbal information is a Intervention_Educational, audio device delivering essentially the same information in verbal form only is a Intervention_Educational, efficiencies is a Outcome_Other, ability to recall the information is a Outcome_Mental	63913_task1	Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please typing these entity words according to sentence: volunteers, prospective Le Fort I osteotomy, multi - media tablet device delivering both graphic and verbal information, audio device delivering essentially the same information in verbal form only, efficiencies, ability to recall the information Options: Participant_Condition, Intervention_Educational, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .	[ "Evaluation", "of", "an", "interactive", "multi", "-", "media", "device", "for", "delivering", "information", "on", "Le", "Fort", "I", "osteotomy", ".", "This", "study", "was", "carried", "out", "on", "volunteers", "to", "evaluate", "a", "newly", "developed", "interactive", "software", "package", "aimed", "at", "informing", "prospective", "Le", "Fort", "I", "osteotomy", "patients", "regarding", "the", "surgical", "technique", "and", "possible", "complications", ".", "The", "aim", "of", "the", "study", "was", "to", "compare", "two", "methods", "of", "information", "delivery", ";", "a", "multi", "-", "media", "tablet", "device", "delivering", "both", "graphic", "and", "verbal", "information", ",", "and", "an", "audio", "device", "delivering", "essentially", "the", "same", "information", "in", "verbal", "form", "only", ".", "The", "null", "hypothesis", "was", "that", "there", "would", "be", "no", "difference", "between", "the", "efficiencies", "of", "the", "two", "methods", ".", "The", "subjects", "'", "ability", "to", "recall", "the", "information", "delivered", "by", "both", "devices", "was", "assessed", "using", "a", "questionnaire", ".", "The", "tablet", "device", "participants", "scored", "an", "average", "of", "15.48", "points", ",", "while", "the", "audio", "device", "participants", "scored", "an", "average", "of", "268", "points", ".", "The", "difference", "was", "statistically", "significant", "(", "p", "<", "0.001", ")", ",", "suggesting", "that", "the", "multi", "-", "media", "tablet", "device", "was", "more", "effective", "method", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
volunteers, prospective Le Fort I osteotomy, multi - media tablet device delivering both graphic and verbal information, audio device delivering essentially the same information in verbal form only, efficiencies, ability to recall the information	63913_task2	Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .	[ "Evaluation", "of", "an", "interactive", "multi", "-", "media", "device", "for", "delivering", "information", "on", "Le", "Fort", "I", "osteotomy", ".", "This", "study", "was", "carried", "out", "on", "volunteers", "to", "evaluate", "a", "newly", "developed", "interactive", "software", "package", "aimed", "at", "informing", "prospective", "Le", "Fort", "I", "osteotomy", "patients", "regarding", "the", "surgical", "technique", "and", "possible", "complications", ".", "The", "aim", "of", "the", "study", "was", "to", "compare", "two", "methods", "of", "information", "delivery", ";", "a", "multi", "-", "media", "tablet", "device", "delivering", "both", "graphic", "and", "verbal", "information", ",", "and", "an", "audio", "device", "delivering", "essentially", "the", "same", "information", "in", "verbal", "form", "only", ".", "The", "null", "hypothesis", "was", "that", "there", "would", "be", "no", "difference", "between", "the", "efficiencies", "of", "the", "two", "methods", ".", "The", "subjects", "'", "ability", "to", "recall", "the", "information", "delivered", "by", "both", "devices", "was", "assessed", "using", "a", "questionnaire", ".", "The", "tablet", "device", "participants", "scored", "an", "average", "of", "15.48", "points", ",", "while", "the", "audio", "device", "participants", "scored", "an", "average", "of", "268", "points", ".", "The", "difference", "was", "statistically", "significant", "(", "p", "<", "0.001", ")", ",", "suggesting", "that", "the", "multi", "-", "media", "tablet", "device", "was", "more", "effective", "method", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]
Biopsien is an umlsterm, Therapieverfahren is an umlsterm, MR - Tomographie is an umlsterm, MR - Tomographie is an umlsterm, Zeit is an umlsterm, MR - Tomographie is an umlsterm, Radiologie is an umlsterm, Therapie is an umlsterm	DerRadiologe.90390741.ger.abstr_task0	Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .	[ "Das", "Spektrum", "MR", "-", "gefuehrter", "Eingriffe", "reicht", "von", "Biopsien", ",", "thermischen", "Therapieverfahren", ",", "vaskulaeren", "Applikationen", "bis", "hin", "zum", "intraoperativen", "Einsatz", "der", "MR", "-", "Tomographie", ".", "Das", "Konzept", "der", "Steuerung", "durch", "die", "MR", "-", "Tomographie", "basiert", "auf", "der", "Kombination", "von", "exzellenter", "morphologischer", "und", "funktioneller", "Bildgebung", ".", "Die", "wichtigsten", "in", "letzter", "Zeit", "vorgelegten", "experimentellen", "und", "klinischen", "Ergebnisse", "werden", "diskutiert", ".", "Es", "ist", "davon", "auszugehen", ",", "dass", "die", "interventionelle", "MR", "-", "Tomographie", "einen", "hohen", "Stellenwert", "im", "Bereich", "der", "interventionellen", "Radiologie", ",", "der", "minimal", "-", "invasiven", "Therapie", "und", "der", "Ueberwachung", "von", "operativen", "Eingriffen", "erlangen", "wird", "." ]	[ "umlsterm" ]
Biopsien is an umlsterm, Therapieverfahren is an umlsterm, MR - Tomographie is an umlsterm, MR - Tomographie is an umlsterm, Zeit is an umlsterm, MR - Tomographie is an umlsterm, Radiologie is an umlsterm, Therapie is an umlsterm	DerRadiologe.90390741.ger.abstr_task1	Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please typing these entity words according to sentence: Biopsien, Therapieverfahren, MR - Tomographie, MR - Tomographie, Zeit, MR - Tomographie, Radiologie, Therapie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .	[ "Das", "Spektrum", "MR", "-", "gefuehrter", "Eingriffe", "reicht", "von", "Biopsien", ",", "thermischen", "Therapieverfahren", ",", "vaskulaeren", "Applikationen", "bis", "hin", "zum", "intraoperativen", "Einsatz", "der", "MR", "-", "Tomographie", ".", "Das", "Konzept", "der", "Steuerung", "durch", "die", "MR", "-", "Tomographie", "basiert", "auf", "der", "Kombination", "von", "exzellenter", "morphologischer", "und", "funktioneller", "Bildgebung", ".", "Die", "wichtigsten", "in", "letzter", "Zeit", "vorgelegten", "experimentellen", "und", "klinischen", "Ergebnisse", "werden", "diskutiert", ".", "Es", "ist", "davon", "auszugehen", ",", "dass", "die", "interventionelle", "MR", "-", "Tomographie", "einen", "hohen", "Stellenwert", "im", "Bereich", "der", "interventionellen", "Radiologie", ",", "der", "minimal", "-", "invasiven", "Therapie", "und", "der", "Ueberwachung", "von", "operativen", "Eingriffen", "erlangen", "wird", "." ]	[ "umlsterm" ]
Biopsien, Therapieverfahren, MR - Tomographie, MR - Tomographie, Zeit, MR - Tomographie, Radiologie, Therapie	DerRadiologe.90390741.ger.abstr_task2	Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .	[ "Das", "Spektrum", "MR", "-", "gefuehrter", "Eingriffe", "reicht", "von", "Biopsien", ",", "thermischen", "Therapieverfahren", ",", "vaskulaeren", "Applikationen", "bis", "hin", "zum", "intraoperativen", "Einsatz", "der", "MR", "-", "Tomographie", ".", "Das", "Konzept", "der", "Steuerung", "durch", "die", "MR", "-", "Tomographie", "basiert", "auf", "der", "Kombination", "von", "exzellenter", "morphologischer", "und", "funktioneller", "Bildgebung", ".", "Die", "wichtigsten", "in", "letzter", "Zeit", "vorgelegten", "experimentellen", "und", "klinischen", "Ergebnisse", "werden", "diskutiert", ".", "Es", "ist", "davon", "auszugehen", ",", "dass", "die", "interventionelle", "MR", "-", "Tomographie", "einen", "hohen", "Stellenwert", "im", "Bereich", "der", "interventionellen", "Radiologie", ",", "der", "minimal", "-", "invasiven", "Therapie", "und", "der", "Ueberwachung", "von", "operativen", "Eingriffen", "erlangen", "wird", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Verletzungen is an umlsterm, Trauma is an umlsterm, Rollenabbrueche is an umlsterm, Frakturen is an umlsterm, Fraktur is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, postoperative Behandlung is an umlsterm, Fusssohlenkontaktbelastung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Patienten is an umlsterm, Langzeitresultate is an umlsterm	DerChirurg.70680072.ger.abstr_task0	Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .	[ "Zusammenfassung", ".", "29", "Patienten", "mit", "moncondylaeren", "Frakturen", "des", "distalen", "Femurs", "wurden", "zwischen", "1981", "und", "1994", "im", "Bergmannsheil", "Bochum", "behandelt", ".", "Alle", "Patienten", "erlitten", "ihre", "Verletzungen", "von", "direktem", "Trauma", ".", "Es", "handelte", "sich", "um", "16", "laterale", "Condylenfrakturen", ",", "7", "mediale", "Condylenfrakturen", "und", "in", "6", "Faellen", "waren", "tangenitale", "Rollenabbrueche", "(", "Hoffa", "-", "Frakturen", ")", "vorhanden", ".", "28", "Frakturen", "waren", "geschlossen", ",", "und", "eine", "Fraktur", "war", "drittgradig", "offen", ".", "Elf", "Patienten", "erlitten", "Begleitverletzungen", "des", "musculoskelettaeren", "Systems", ".", "Alle", "Frakturen", "wurden", "mit", "offener", "anatomischer", "Reposition", "und", "stabiler", "interner", "Fixation", "mit", "Spongiosazugschrauben", "behandelt", ".", "Die", "postoperative", "Behandlung", "beinhaltete", "fruehe", "passive", "Bewegung", "auf", "der", "Elektroschiene", "und", "Fusssohlenkontaktbelastung", "fuer", "6", "-", "8", "Wochen", ".", "Der", "durchschnittliche", "Nachuntersuchungszeitraum", "betrug", "68", "Monate", ".", "Die", "Behandlungsergebnisse", "wurden", "nach", "dem", "Neer", "-", "Score", "bewertet", ".", "27", "von", "29", "Patienten", "konnten", "nachuntersucht", "werden", ".", "23", "Patienten", "hatten", "ein", "exzellentes", "Resultat", ",", "3", "Patienten", "ein", "befriedigendes", "Resultat", ",", "1", "Patient", "hatte", "ein", "unbefriedigendes", "Resultat", ".", "Alle", "Patienten", "ohne", "exzellentes", "Resultat", "hatten", "Begleitverletzungen", ".", "Die", "offene", "anatomische", "Reposition", "und", "interne", "Schraubenfixation", "bei", "monocondylaeren", "Femurfrakturen", "sorgt", "bei", "Monoverletzungen", "fuer", "hervorragende", "Langzeitresultate", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Verletzungen is an umlsterm, Trauma is an umlsterm, Rollenabbrueche is an umlsterm, Frakturen is an umlsterm, Fraktur is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, postoperative Behandlung is an umlsterm, Fusssohlenkontaktbelastung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Patienten is an umlsterm, Langzeitresultate is an umlsterm	DerChirurg.70680072.ger.abstr_task1	Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please typing these entity words according to sentence: Patienten, Frakturen, Patienten, Verletzungen, Trauma, Rollenabbrueche, Frakturen, Fraktur, Patienten, Frakturen, postoperative Behandlung, Fusssohlenkontaktbelastung, Patienten, Patienten, Patienten, Patient, Patienten, Langzeitresultate Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .	[ "Zusammenfassung", ".", "29", "Patienten", "mit", "moncondylaeren", "Frakturen", "des", "distalen", "Femurs", "wurden", "zwischen", "1981", "und", "1994", "im", "Bergmannsheil", "Bochum", "behandelt", ".", "Alle", "Patienten", "erlitten", "ihre", "Verletzungen", "von", "direktem", "Trauma", ".", "Es", "handelte", "sich", "um", "16", "laterale", "Condylenfrakturen", ",", "7", "mediale", "Condylenfrakturen", "und", "in", "6", "Faellen", "waren", "tangenitale", "Rollenabbrueche", "(", "Hoffa", "-", "Frakturen", ")", "vorhanden", ".", "28", "Frakturen", "waren", "geschlossen", ",", "und", "eine", "Fraktur", "war", "drittgradig", "offen", ".", "Elf", "Patienten", "erlitten", "Begleitverletzungen", "des", "musculoskelettaeren", "Systems", ".", "Alle", "Frakturen", "wurden", "mit", "offener", "anatomischer", "Reposition", "und", "stabiler", "interner", "Fixation", "mit", "Spongiosazugschrauben", "behandelt", ".", "Die", "postoperative", "Behandlung", "beinhaltete", "fruehe", "passive", "Bewegung", "auf", "der", "Elektroschiene", "und", "Fusssohlenkontaktbelastung", "fuer", "6", "-", "8", "Wochen", ".", "Der", "durchschnittliche", "Nachuntersuchungszeitraum", "betrug", "68", "Monate", ".", "Die", "Behandlungsergebnisse", "wurden", "nach", "dem", "Neer", "-", "Score", "bewertet", ".", "27", "von", "29", "Patienten", "konnten", "nachuntersucht", "werden", ".", "23", "Patienten", "hatten", "ein", "exzellentes", "Resultat", ",", "3", "Patienten", "ein", "befriedigendes", "Resultat", ",", "1", "Patient", "hatte", "ein", "unbefriedigendes", "Resultat", ".", "Alle", "Patienten", "ohne", "exzellentes", "Resultat", "hatten", "Begleitverletzungen", ".", "Die", "offene", "anatomische", "Reposition", "und", "interne", "Schraubenfixation", "bei", "monocondylaeren", "Femurfrakturen", "sorgt", "bei", "Monoverletzungen", "fuer", "hervorragende", "Langzeitresultate", "." ]	[ "umlsterm" ]
Patienten, Frakturen, Patienten, Verletzungen, Trauma, Rollenabbrueche, Frakturen, Fraktur, Patienten, Frakturen, postoperative Behandlung, Fusssohlenkontaktbelastung, Patienten, Patienten, Patienten, Patient, Patienten, Langzeitresultate	DerChirurg.70680072.ger.abstr_task2	Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .	[ "Zusammenfassung", ".", "29", "Patienten", "mit", "moncondylaeren", "Frakturen", "des", "distalen", "Femurs", "wurden", "zwischen", "1981", "und", "1994", "im", "Bergmannsheil", "Bochum", "behandelt", ".", "Alle", "Patienten", "erlitten", "ihre", "Verletzungen", "von", "direktem", "Trauma", ".", "Es", "handelte", "sich", "um", "16", "laterale", "Condylenfrakturen", ",", "7", "mediale", "Condylenfrakturen", "und", "in", "6", "Faellen", "waren", "tangenitale", "Rollenabbrueche", "(", "Hoffa", "-", "Frakturen", ")", "vorhanden", ".", "28", "Frakturen", "waren", "geschlossen", ",", "und", "eine", "Fraktur", "war", "drittgradig", "offen", ".", "Elf", "Patienten", "erlitten", "Begleitverletzungen", "des", "musculoskelettaeren", "Systems", ".", "Alle", "Frakturen", "wurden", "mit", "offener", "anatomischer", "Reposition", "und", "stabiler", "interner", "Fixation", "mit", "Spongiosazugschrauben", "behandelt", ".", "Die", "postoperative", "Behandlung", "beinhaltete", "fruehe", "passive", "Bewegung", "auf", "der", "Elektroschiene", "und", "Fusssohlenkontaktbelastung", "fuer", "6", "-", "8", "Wochen", ".", "Der", "durchschnittliche", "Nachuntersuchungszeitraum", "betrug", "68", "Monate", ".", "Die", "Behandlungsergebnisse", "wurden", "nach", "dem", "Neer", "-", "Score", "bewertet", ".", "27", "von", "29", "Patienten", "konnten", "nachuntersucht", "werden", ".", "23", "Patienten", "hatten", "ein", "exzellentes", "Resultat", ",", "3", "Patienten", "ein", "befriedigendes", "Resultat", ",", "1", "Patient", "hatte", "ein", "unbefriedigendes", "Resultat", ".", "Alle", "Patienten", "ohne", "exzellentes", "Resultat", "hatten", "Begleitverletzungen", ".", "Die", "offene", "anatomische", "Reposition", "und", "interne", "Schraubenfixation", "bei", "monocondylaeren", "Femurfrakturen", "sorgt", "bei", "Monoverletzungen", "fuer", "hervorragende", "Langzeitresultate", "." ]	[ "umlsterm" ]
Myosin is an umlsterm	DerGynaekologe.00330344.ger.abstr_task0	Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .	[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]	[ "umlsterm" ]
Myosin is an umlsterm	DerGynaekologe.00330344.ger.abstr_task1	Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please typing these entity words according to sentence: Myosin Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .	[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]	[ "umlsterm" ]
Myosin	DerGynaekologe.00330344.ger.abstr_task2	Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .	[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]	[ "umlsterm" ]
RCC1 is a protein, serine is a compound, cdc2 is a protein	DS.d365_task0	Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]	Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.	[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]	[ "compound", "protein" ]
RCC1 is a protein, serine is a compound, cdc2 is a protein	DS.d365_task1	Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please typing these entity words according to sentence: RCC1, serine, cdc2 Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]	Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.	[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]	[ "compound", "protein" ]
RCC1, serine, cdc2	DS.d365_task2	Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]	Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.	[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]	[ "compound", "protein" ]
psychotherapy is an umlsterm, psychoanalytic therapy is an umlsterm, hand is an umlsterm, guidelines is an umlsterm, hand is an umlsterm, self - conception is an umlsterm, psychotherapy is an umlsterm, conflicts is an umlsterm, psychotherapy is an umlsterm, distance is an umlsterm, psychoanalytic therapy is an umlsterm, development is an umlsterm, psychotherapy is an umlsterm	ForumDerPsychoanalyse.80140258.eng.abstr_task0	Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .	[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]	[ "umlsterm" ]
psychotherapy is an umlsterm, psychoanalytic therapy is an umlsterm, hand is an umlsterm, guidelines is an umlsterm, hand is an umlsterm, self - conception is an umlsterm, psychotherapy is an umlsterm, conflicts is an umlsterm, psychotherapy is an umlsterm, distance is an umlsterm, psychoanalytic therapy is an umlsterm, development is an umlsterm, psychotherapy is an umlsterm	ForumDerPsychoanalyse.80140258.eng.abstr_task1	Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please typing these entity words according to sentence: psychotherapy, psychoanalytic therapy, hand, guidelines, hand, self - conception, psychotherapy, conflicts, psychotherapy, distance, psychoanalytic therapy, development, psychotherapy Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .	[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]	[ "umlsterm" ]
psychotherapy, psychoanalytic therapy, hand, guidelines, hand, self - conception, psychotherapy, conflicts, psychotherapy, distance, psychoanalytic therapy, development, psychotherapy	ForumDerPsychoanalyse.80140258.eng.abstr_task2	Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .	[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]	[ "umlsterm" ]
Psoriasis is an umlsterm, Entzuendung is an umlsterm, Tiermodellen is an umlsterm, Psoriasispathogenese is an umlsterm, Tiermodellen is an umlsterm, Psoriasis is an umlsterm, Elemente is an umlsterm, Transplantationsmodell is an umlsterm	DerHautarzt.70480707.ger.abstr_task0	Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .	[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]	[ "umlsterm" ]
Psoriasis is an umlsterm, Entzuendung is an umlsterm, Tiermodellen is an umlsterm, Psoriasispathogenese is an umlsterm, Tiermodellen is an umlsterm, Psoriasis is an umlsterm, Elemente is an umlsterm, Transplantationsmodell is an umlsterm	DerHautarzt.70480707.ger.abstr_task1	Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please typing these entity words according to sentence: Psoriasis, Entzuendung, Tiermodellen, Psoriasispathogenese, Tiermodellen, Psoriasis, Elemente, Transplantationsmodell Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .	[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]	[ "umlsterm" ]
Psoriasis, Entzuendung, Tiermodellen, Psoriasispathogenese, Tiermodellen, Psoriasis, Elemente, Transplantationsmodell	DerHautarzt.70480707.ger.abstr_task2	Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .	[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]	[ "umlsterm" ]
colágeno is a PROTEINAS, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, CD 68 is a PROTEINAS, Tc 99 m difosfato is a NORMALIZABLES, corticoides is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES	191_task0	Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.	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colágeno is a PROTEINAS, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, CD 68 is a PROTEINAS, Tc 99 m difosfato is a NORMALIZABLES, corticoides is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES	191_task1	Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. Instructions: please typing these entity words according to sentence: colágeno, metilprednisolona, Urbason, CD 68, Tc 99 m difosfato, corticoides, metilprednisolona, Urbason, metilprednisolona, Urbason Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.	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colágeno, metilprednisolona, Urbason, CD 68, Tc 99 m difosfato, corticoides, metilprednisolona, Urbason, metilprednisolona, Urbason	191_task2	Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. 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En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.	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anticholinergic drugs is a GROUP, anticholinergic drugs is a GROUP, decongestants is a GROUP, anesthetics is a GROUP, sympathomimetic amine is a GROUP, epinephrine is a DRUG, norepinephrine is a DRUG, tricyclic antidepressants is a GROUP, imipramine hydrochloride is a DRUG, Imipramine hydrochloride is a DRUG, CNS depressant drugs is a GROUP, imipramine is a DRUG, cimetidine is a DRUG, fluoxetine is a DRUG, barbiturates is a GROUP, phenytoin is a DRUG, imipramine is a DRUG, tricyclic antidepressants is a GROUP, TCAs is a GROUP, TCA is a GROUP, TCA is a GROUP, quinidine is a DRUG, cimetidine is a DRUG, antidepressants is a GROUP, phenothiazines is a GROUP, Type 1C antiarrhythmics is a GROUP, propafenone is a DRUG, flecainide is a DRUG, selective serotonin reuptake inhibitors is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, sertraline is a DRUG, paroxetine is a DRUG, SSRI is a GROUP, TCA is a GROUP, SSRI is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, tricyclic antidepressants is a GROUP, tricyclic antidepressant is a GROUP, tricyclic antidepressant is a GROUP, TCA is a GROUP, TCA is a GROUP	Imipramine_ddi_task0	Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.	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anticholinergic drugs is a GROUP, anticholinergic drugs is a GROUP, decongestants is a GROUP, anesthetics is a GROUP, sympathomimetic amine is a GROUP, epinephrine is a DRUG, norepinephrine is a DRUG, tricyclic antidepressants is a GROUP, imipramine hydrochloride is a DRUG, Imipramine hydrochloride is a DRUG, CNS depressant drugs is a GROUP, imipramine is a DRUG, cimetidine is a DRUG, fluoxetine is a DRUG, barbiturates is a GROUP, phenytoin is a DRUG, imipramine is a DRUG, tricyclic antidepressants is a GROUP, TCAs is a GROUP, TCA is a GROUP, TCA is a GROUP, quinidine is a DRUG, cimetidine is a DRUG, antidepressants is a GROUP, phenothiazines is a GROUP, Type 1C antiarrhythmics is a GROUP, propafenone is a DRUG, flecainide is a DRUG, selective serotonin reuptake inhibitors is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, sertraline is a DRUG, paroxetine is a DRUG, SSRI is a GROUP, TCA is a GROUP, SSRI is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, tricyclic antidepressants is a GROUP, tricyclic antidepressant is a GROUP, tricyclic antidepressant is a GROUP, TCA is a GROUP, TCA is a GROUP	Imipramine_ddi_task1	Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please typing these entity words according to sentence: anticholinergic drugs, anticholinergic drugs, decongestants, anesthetics, sympathomimetic amine, epinephrine, norepinephrine, tricyclic antidepressants, imipramine hydrochloride, Imipramine hydrochloride, CNS depressant drugs, imipramine, cimetidine, fluoxetine, barbiturates, phenytoin, imipramine, tricyclic antidepressants, TCAs, TCA, TCA, quinidine, cimetidine, antidepressants, phenothiazines, Type 1C antiarrhythmics, propafenone, flecainide, selective serotonin reuptake inhibitors, SSRIs, fluoxetine, sertraline, paroxetine, SSRI, TCA, SSRI, SSRIs, fluoxetine, tricyclic antidepressants, tricyclic antidepressant, tricyclic antidepressant, TCA, TCA Options: GROUP, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.	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"may", "become", "abruptly", "toxic", "when", "given", "one", "of", "these", "inhibiting", "drugs", "as", "concomitant", "therapy", ".", "The", "drugs", "that", "inhibit", "cytochrome", "P450", "2D6", "include", "some", "that", "are", "not", "metabolized", "by", "the", "enzyme", "(", "quinidine", ";", "cimetidine", ")", "and", "many", "that", "are", "substrates", "for", "P450", "2D6", "(", "many", "other", "antidepressants", ",", "phenothiazines", ",", "and", "the", "Type", "1C", "antiarrhythmics", "propafenone", "and", "flecainide", ")", ".", "While", "all", "the", "selective", "serotonin", "reuptake", "inhibitors", "(", "SSRIs", ")", ",", "e.", "g.", ",", "fluoxetine", ",", "sertraline", ",", "and", "paroxetine", ",", "inhibit", "P450", "2D6", ",", "they", "may", "vary", "in", "the", "extent", "of", "inhibition", ".", "The", "extent", "to", "which", "SSRI", "-", "TCA", "interactions", "may", "pose", "clinical", "problems", "will", "depend", "on", "the", "degree", "of", "inhibition", ",", "and", "the", "pharmacokinetics", "of", "the", "SSRI", "involved", ".", "Nevertheless", ",", "caution", "is", "indicated", "in", "the", "co", "-", "administration", "of", "TCA5", "with", "any", "of", "the", "SSRIs", "and", "also", "in", "switching", "from", "one", "class", "to", "the", "other", ".", "Of", "particular", "importance", ",", "sufficient", "time", "must", "elapse", "before", "initiating", "TCA", "treatment", "in", "a", "patient", "being", "withdrawn", "from", "fluoxetine", ",", "given", "the", "long", "half", "-", "life", "of", "the", "parent", "and", "active", "metabolite", "(", "at", "least", "5", "weeks", "may", "be", "necessary", ")", ".", "Concomitant", "use", "of", "tricyclic", "antidepressants", "with", "drugs", "that", "can", "inhibit", "cytochrome", "P450", "2D6", "may", "require", "lower", "doses", "than", "usually", "prescribed", "for", "either", "the", "tricyclic", "antidepressant", "or", "the", "other", "drug", ".", "Furthermore", ",", "whenever", "one", 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anticholinergic drugs, anticholinergic drugs, decongestants, anesthetics, sympathomimetic amine, epinephrine, norepinephrine, tricyclic antidepressants, imipramine hydrochloride, Imipramine hydrochloride, CNS depressant drugs, imipramine, cimetidine, fluoxetine, barbiturates, phenytoin, imipramine, tricyclic antidepressants, TCAs, TCA, TCA, quinidine, cimetidine, antidepressants, phenothiazines, Type 1C antiarrhythmics, propafenone, flecainide, selective serotonin reuptake inhibitors, SSRIs, fluoxetine, sertraline, paroxetine, SSRI, TCA, SSRI, SSRIs, fluoxetine, tricyclic antidepressants, tricyclic antidepressant, tricyclic antidepressant, TCA, TCA	Imipramine_ddi_task2	Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.	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breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean is a Plant, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean oil is a Plant, breast cancer is a Disease	12223422_task0	Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "I-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O" ]	Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.	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breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean is a Plant, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean oil is a Plant, breast cancer is a Disease	12223422_task1	Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please typing these entity words according to sentence: breast cancer, breast cancer, breast cancer, breast cancer, soybean, breast cancer, breast cancer, breast cancer, soybean oil, breast cancer Options: Disease, Plant	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "I-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O" ]	Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.	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breast cancer, breast cancer, breast cancer, breast cancer, soybean, breast cancer, breast cancer, breast cancer, soybean oil, breast cancer	12223422_task2	Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "I-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O" ]	Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.	[ "Cumulative", "evidence", "suggests", "a", "possible", "interaction", "of", "cooking", "methods", "with", "diet", "in", "the", "pathogenesis", "of", "breast", "cancer", ".", "Studies", ",", "however", ",", "are", "few", "and", "inconsistent", ".", "We", "evaluated", "the", "association", "of", "animal", "food", "intake", "and", "degree", "of", "browning", "by", "deep", "-", "frying", "with", "breast", "cancer", "risk", "in", "a", "population", "-", "based", "case", "-", "control", "study", "conducted", "during", "1996", "-", "1998", "among", "Chinese", "women", "in", "Shanghai", ",", "a", "population", "with", "a", "traditionally", "low", "risk", "of", "breast", "cancer", ".", "Included", "in", "the", "study", "were", "1459", "cases", "and", "1556", "age", "-", "frequency", "-", "matched", "controls", "with", "response", "rates", "of", "91.1", "and", "90.3", "%", ",", "respectively", ".", "A", "validated", "food", "frequency", "questionnaire", "was", "used", "to", "obtain", "information", "on", "usual", "intake", "of", "animal", "foods", "and", "cooking", "oils", "and", "usual", "cooking", "methods", ".", "Increasing", "intake", "of", "red", "meat", "and", "freshwater", "fish", "was", "related", "to", "a", "moderately", "elevated", "risk", "of", "breast", "cancer", "risk", ".", "Stratified", "analyses", "showed", "that", "the", "positive", "association", "with", "red", "meat", "intake", "was", "primarily", "restricted", "to", "those", "who", "used", "deep", "-", "frying", "cooking", "method", ",", "particularly", "among", "those", "who", "deep", "-", "fried", "foods", "to", "well", "-", "done", "(", "odds", "ratio", ",", "1.92", ";", "95", "%", "confidence", "interval", ",", "1.30", "-", "2.83", "for", "the", "highest", "versus", "the", "lowest", "quintile", ";", "P", "for", "trend", ",", "0.002", ")", ".", "On", "the", "other", "hand", ",", "high", "intake", "of", "nonhydrogenated", "soybean", "cooking", "oil", "was", "related", "to", "a", "reduced", "risk", "of", "breast", "cancer", "among", "women", "who", "never", "deep", "-", "fried", "animal", "foods", "(", "odds", "ratio", ",", "0.48", ";", "95", "%", "confidence", "interval", ",", "0.28", "-", "0.82", "for", "the", "highest", "versus", "the", "lowest", "quintile", ";", "P", "for", "trend", ",", "0.02", ")", ".", "The", "positive", "association", "of", "breast", "cancer", "risk", "with", "red", "meat", "intake", ",", "especially", "well", "-", "done", "red", "meat", ",", "was", "more", "pronounced", "among", "women", "with", "a", "high", "body", "mass", "index", "than", "those", "without", "this", "risk", "factor", ",", "and", "the", "test", "for", "multiplicative", "interaction", "was", "statistically", "significant", ".", "This", "study", "suggests", "that", "high", "intake", "of", "deep", "-", "fried", ",", "well", "-", "done", "red", "meat", "may", "be", "associated", "with", "an", "increased", "risk", "of", "breast", "cancer", ",", "and", "the", "positive", "association", "may", "be", "modified", "by", "body", "weight", ".", "This", "study", "also", "suggests", "that", "nonhydrogenated", "soybean", "oil", ",", "if", "not", "used", "in", "high", "-", "temperature", "cooking", ",", "may", "be", "associated", "with", "a", "reduced", "risk", "of", "breast", "cancer", "." ]	[ "Disease", "Plant" ]
Radiotherapy is an umlsterm, standard is an umlsterm, therapy is an umlsterm, stage is an umlsterm, testicular seminoma is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm, stage is an umlsterm, disease is an umlsterm, stage is an umlsterm, Disease is an umlsterm, survival is an umlsterm, radiotherapy is an umlsterm, treatment is an umlsterm, choice is an umlsterm, neoplasia is an umlsterm, TIN is an umlsterm, testis is an umlsterm, TIN is an umlsterm, carcinoma is an umlsterm, testis is an umlsterm, Objectives is an umlsterm, clinical research is an umlsterm, radiotherapy is an umlsterm, malignancies is an umlsterm, aim is an umlsterm, treatment is an umlsterm, side effects is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm	DerUrologeA.00390126.eng.abstr_task0	Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .	[ "Radiotherapy", "unequivocally", "has", "to", "be", "regarded", "as", "standard", "therapy", "in", "stage", "I", "and", "IIA", "/", "B", "testicular", "seminoma", ".", "Using", "low", "dose", "abdominal", "irradiation", "tumour", "control", "rates", "of", "95", "-", "98", "%", "in", "stage", "I", "disease", "and", "80", "-", "95", "%", "in", "stage", "IIA", "/", "B", "can", "be", "achieved", ".", "Disease", "specific", "survival", "reaches", "100", "%", ".", "Likewise", ",", "radiotherapy", "is", "treatment", "of", "first", "choice", "in", "case", "of", "testicular", "intraepithelial", "neoplasia", "(", "TIN", ")", "in", "a", "solitary", "testis", "or", "in", "case", "of", "a", "double", "-", "sided", "TIN", "yielding", "safe", "eradication", "of", "the", "in", "-", "situ", "carcinoma", "of", "the", "testis", ".", "Objectives", "of", "further", "clinical", "research", "in", "radiotherapy", "of", "testicular", "malignancies", "aim", "at", "reduction", "of", "treatment", "intensity", "in", "order", "to", "minimize", "acute", "and", "late", "side", "effects", "of", "irradiation", "without", "compromising", "tumour", "control", "rates", "." ]	[ "umlsterm" ]
Radiotherapy is an umlsterm, standard is an umlsterm, therapy is an umlsterm, stage is an umlsterm, testicular seminoma is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm, stage is an umlsterm, disease is an umlsterm, stage is an umlsterm, Disease is an umlsterm, survival is an umlsterm, radiotherapy is an umlsterm, treatment is an umlsterm, choice is an umlsterm, neoplasia is an umlsterm, TIN is an umlsterm, testis is an umlsterm, TIN is an umlsterm, carcinoma is an umlsterm, testis is an umlsterm, Objectives is an umlsterm, clinical research is an umlsterm, radiotherapy is an umlsterm, malignancies is an umlsterm, aim is an umlsterm, treatment is an umlsterm, side effects is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm	DerUrologeA.00390126.eng.abstr_task1	Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please typing these entity words according to sentence: Radiotherapy, standard, therapy, stage, testicular seminoma, irradiation, tumour, control, stage, disease, stage, Disease, survival, radiotherapy, treatment, choice, neoplasia, TIN, testis, TIN, carcinoma, testis, Objectives, clinical research, radiotherapy, malignancies, aim, treatment, side effects, irradiation, tumour, control Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .	[ "Radiotherapy", "unequivocally", "has", "to", "be", "regarded", "as", "standard", "therapy", "in", "stage", "I", "and", "IIA", "/", "B", "testicular", "seminoma", ".", "Using", "low", "dose", "abdominal", "irradiation", "tumour", "control", "rates", "of", "95", "-", "98", "%", "in", "stage", "I", "disease", "and", "80", "-", "95", "%", "in", "stage", "IIA", "/", "B", "can", "be", "achieved", ".", "Disease", "specific", "survival", "reaches", "100", "%", ".", "Likewise", ",", "radiotherapy", "is", "treatment", "of", "first", "choice", "in", "case", "of", "testicular", "intraepithelial", "neoplasia", "(", "TIN", ")", "in", "a", "solitary", "testis", "or", "in", "case", "of", "a", "double", "-", "sided", "TIN", "yielding", "safe", "eradication", "of", "the", "in", "-", "situ", "carcinoma", "of", "the", "testis", ".", "Objectives", "of", "further", "clinical", "research", "in", "radiotherapy", "of", "testicular", "malignancies", "aim", "at", "reduction", "of", "treatment", "intensity", "in", "order", "to", "minimize", "acute", "and", "late", "side", "effects", "of", "irradiation", "without", "compromising", "tumour", "control", "rates", "." ]	[ "umlsterm" ]
Radiotherapy, standard, therapy, stage, testicular seminoma, irradiation, tumour, control, stage, disease, stage, Disease, survival, radiotherapy, treatment, choice, neoplasia, TIN, testis, TIN, carcinoma, testis, Objectives, clinical research, radiotherapy, malignancies, aim, treatment, side effects, irradiation, tumour, control	DerUrologeA.00390126.eng.abstr_task2	Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .	[ "Radiotherapy", "unequivocally", "has", "to", "be", "regarded", "as", "standard", "therapy", "in", "stage", "I", "and", "IIA", "/", "B", "testicular", "seminoma", ".", "Using", "low", "dose", "abdominal", "irradiation", "tumour", "control", "rates", "of", "95", "-", "98", "%", "in", "stage", "I", "disease", "and", "80", "-", "95", "%", "in", "stage", "IIA", "/", "B", "can", "be", "achieved", ".", "Disease", "specific", "survival", "reaches", "100", "%", ".", "Likewise", ",", "radiotherapy", "is", "treatment", "of", "first", "choice", "in", "case", "of", "testicular", "intraepithelial", "neoplasia", "(", "TIN", ")", "in", "a", "solitary", "testis", "or", "in", "case", "of", "a", "double", "-", "sided", "TIN", "yielding", "safe", "eradication", "of", "the", "in", "-", "situ", "carcinoma", "of", "the", "testis", ".", "Objectives", "of", "further", "clinical", "research", "in", "radiotherapy", "of", "testicular", "malignancies", "aim", "at", "reduction", "of", "treatment", "intensity", "in", "order", "to", "minimize", "acute", "and", "late", "side", "effects", "of", "irradiation", "without", "compromising", "tumour", "control", "rates", "." ]	[ "umlsterm" ]
Sun protection behaviors is a Intervention_Educational, skin cancers is a Participant_Condition, 2,324 is a Participant_Sample-size, sun protection behaviors is a Intervention_Educational, avoid the sun during midday is a Intervention_Educational, sunscreen is a Intervention_Other, sun protective behaviors is a Intervention_Educational	5780_task0	Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Intervention_Other, Participant_Condition, Participant_Sample-size	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .	[ "Sun", "protection", "behaviors", "and", "stages", "of", "change", "for", "the", "primary", "prevention", "of", "skin", "cancers", "among", "beachgoers", "in", "southeastern", "New", "England", ".", "Sun", "exposure", "is", "the", "most", "important", "avoidable", "cause", "of", "skin", "cancers", ".", "We", "report", "characteristics", "of", "a", "representative", "sample", "(", "N", "=", "2,324", ")", "of", "beachgoers", "in", "Southeastern", "New", "England", "during", "the", "summer", "of", "1995", ".", "This", "sample", "was", "not", "employing", "adequate", "sun", "protection", "behaviors", "(", "83", "%", "did", "not", "often", "avoid", "the", "sun", "during", "midday", "and", "only", "45", "%", "often", "used", "sunscreen", ")", ".", "Important", "demographic", "and", "skin", "cancer", "risk", "factor", "differences", "in", "sun", "protective", "behaviors", "and", "stages", "of", "change", "for", "sun", "protection", "were", "found", ",", "especially", "differences", "based", "on", "age", ",", "gender", ",", "and", "degree", "of", "sun", "sensitivity", ".", "Consistent", "with", "previous", "research", ",", "increased", "age", ",", "female", "gender", ",", "and", "greater", "sun", "sensitivity", "were", "each", "independently", "associated", "with", "more", "sun", "protective", "behaviors", ".", "These", "findings", "underscore", "the", "need", "for", "interventions", "targeting", "high", "-", "risk", "populations", ",", "such", "as", "those", "receiving", "high", "-", "intensity", "sun", "exposures", "at", "the", "beach", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Other", "Participant_Sample-size" ]
Sun protection behaviors is a Intervention_Educational, skin cancers is a Participant_Condition, 2,324 is a Participant_Sample-size, sun protection behaviors is a Intervention_Educational, avoid the sun during midday is a Intervention_Educational, sunscreen is a Intervention_Other, sun protective behaviors is a Intervention_Educational	5780_task1	Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please typing these entity words according to sentence: Sun protection behaviors, skin cancers, 2,324, sun protection behaviors, avoid the sun during midday, sunscreen, sun protective behaviors Options: Intervention_Educational, Intervention_Other, Participant_Condition, Participant_Sample-size	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .	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Sun protection behaviors, skin cancers, 2,324, sun protection behaviors, avoid the sun during midday, sunscreen, sun protective behaviors	5780_task2	Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .	[ "Sun", "protection", "behaviors", "and", "stages", "of", "change", "for", "the", "primary", "prevention", "of", "skin", "cancers", "among", "beachgoers", "in", "southeastern", "New", "England", ".", "Sun", "exposure", "is", "the", "most", "important", "avoidable", "cause", "of", "skin", "cancers", ".", "We", "report", "characteristics", "of", "a", "representative", "sample", "(", "N", "=", "2,324", ")", "of", "beachgoers", "in", "Southeastern", "New", "England", "during", "the", "summer", "of", "1995", ".", "This", "sample", "was", "not", "employing", "adequate", "sun", "protection", "behaviors", "(", "83", "%", "did", "not", "often", "avoid", "the", "sun", "during", "midday", "and", "only", "45", "%", "often", "used", "sunscreen", ")", ".", "Important", "demographic", "and", "skin", "cancer", "risk", "factor", "differences", "in", "sun", "protective", "behaviors", "and", "stages", "of", "change", "for", "sun", "protection", "were", "found", ",", "especially", "differences", "based", "on", "age", ",", "gender", ",", "and", "degree", "of", "sun", "sensitivity", ".", "Consistent", "with", "previous", "research", ",", "increased", "age", ",", "female", "gender", ",", "and", "greater", "sun", "sensitivity", "were", "each", "independently", "associated", "with", "more", "sun", "protective", "behaviors", ".", "These", "findings", "underscore", "the", "need", "for", "interventions", "targeting", "high", "-", "risk", "populations", ",", "such", "as", "those", "receiving", "high", "-", "intensity", "sun", "exposures", "at", "the", "beach", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Other", "Participant_Sample-size" ]
defibrillation is an umlsterm, emergency is an umlsterm, Germany is an umlsterm, use is an umlsterm, physicians is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, EMT is an umlsterm, emergency medical technician is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, life is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, survival is an umlsterm, survival is an umlsterm, emergency is an umlsterm, defibrillation is an umlsterm, program is an umlsterm, personnel is an umlsterm, basic life support is an umlsterm, defibrillation is an umlsterm, emergency is an umlsterm, physician is an umlsterm, paramedics is an umlsterm, training is an umlsterm, use is an umlsterm, personnel is an umlsterm, use is an umlsterm, defibrillation is an umlsterm, programs is an umlsterm, American Heart Association is an umlsterm, Resuscitation is an umlsterm, use is an umlsterm, devices is an umlsterm, personnel is an umlsterm, policemen is an umlsterm, personnel is an umlsterm, recommendation is an umlsterm	IntensiveMedizin.00370062.eng.abstr_task0	Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .	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defibrillation is an umlsterm, emergency is an umlsterm, Germany is an umlsterm, use is an umlsterm, physicians is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, EMT is an umlsterm, emergency medical technician is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, life is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, survival is an umlsterm, survival is an umlsterm, emergency is an umlsterm, defibrillation is an umlsterm, program is an umlsterm, personnel is an umlsterm, basic life support is an umlsterm, defibrillation is an umlsterm, emergency is an umlsterm, physician is an umlsterm, paramedics is an umlsterm, training is an umlsterm, use is an umlsterm, personnel is an umlsterm, use is an umlsterm, defibrillation is an umlsterm, programs is an umlsterm, American Heart Association is an umlsterm, Resuscitation is an umlsterm, use is an umlsterm, devices is an umlsterm, personnel is an umlsterm, policemen is an umlsterm, personnel is an umlsterm, recommendation is an umlsterm	IntensiveMedizin.00370062.eng.abstr_task1	Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please typing these entity words according to sentence: defibrillation, emergency, Germany, use, physicians, defibrillation, defibrillation, EMT, emergency medical technician, defibrillation, defibrillation, defibrillation, life, defibrillation, defibrillation, survival, survival, emergency, defibrillation, program, personnel, basic life support, defibrillation, emergency, physician, paramedics, training, use, personnel, use, defibrillation, programs, American Heart Association, Resuscitation, use, devices, personnel, policemen, personnel, recommendation Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .	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defibrillation, emergency, Germany, use, physicians, defibrillation, defibrillation, EMT, emergency medical technician, defibrillation, defibrillation, defibrillation, life, defibrillation, defibrillation, survival, survival, emergency, defibrillation, program, personnel, basic life support, defibrillation, emergency, physician, paramedics, training, use, personnel, use, defibrillation, programs, American Heart Association, Resuscitation, use, devices, personnel, policemen, personnel, recommendation	IntensiveMedizin.00370062.eng.abstr_task2	Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .	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Blood pressure biofeedback treatment is a Intervention_Psychological, blood pressure is a Outcome_Physical, BP is a Outcome_Physical, biofeedback treatment ( BF ) is a Intervention_Psychological, Fifteen is a Participant_Sample-size, white - coat hypertensive is a Participant_Condition, 23 is a Participant_Sample-size, essential hypertensive is a Participant_Condition, visited the clinic is a Intervention_Physical, BPs of white - coat hypertensives and essential hypertensives is a Outcome_Physical, pulse is a Outcome_Physical, respiratory rates is a Outcome_Physical, elevation of diastolic BP due to mental stress testing is a Outcome_Physical	3063_task0	Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .	[ "Blood", "pressure", "biofeedback", "treatment", "of", "white", "-", "coat", "hypertension", ".", "OBJECTIVE", "The", "objective", "of", "the", "study", "was", "to", "compare", "blood", "pressure", "(", "BP", ")", "biofeedback", "treatment", "(", "BF", ")", "effects", "between", "white", "-", "coat", "hypertension", "and", "essential", "hypertension", ".", "METHODS", "Fifteen", "white", "-", "coat", "hypertensive", "out", "-", "patients", "and", "23", "essential", "hypertensive", "out", "-", "patients", "were", "randomly", "assigned", "to", "groups", "A", "or", "B", ".", "Subjects", "in", "group", "A", "underwent", "BF", "once", "a", "week", "for", "a", "total", "of", "four", "sessions", ".", "Those", "in", "group", "B", "visited", "the", "clinic", "only", "to", "measure", "BP", "and", "later", "underwent", "the", "same", "BF", ".", "RESULTS", "In", "group", "A", ",", "BPs", "of", "white", "-", "coat", "hypertensives", "and", "essential", "hypertensives", "were", "significantly", "reduced", "by", "22/11", "and", "14/8", "mmHg", ",", "respectively", ".", "In", "group", "B", ",", "they", "were", "unchanged", "during", "the", "same", "period", "but", "later", "suppressed", "by", "BF", ".", "Under", "BF", ",", "pulse", "and", "respiratory", "rates", "were", "significantly", "higher", ",", "and", "elevation", "of", "diastolic", "BP", "due", "to", "mental", "stress", "testing", "was", "better", "suppressed", "in", "white", "-", "coat", "hypertensives", "than", "in", "essential", "hypertensives", ".", "CONCLUSION", "This", "treatment", "was", "effective", "in", "both", "types", "of", "hypertension", ",", "and", "pressor", "response", "to", "stress", "seems", "to", "be", "important", "in", "the", "differentiated", "BF", "effect", "." ]	[ "Outcome_Physical", "Intervention_Psychological", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Other" ]
Blood pressure biofeedback treatment is a Intervention_Psychological, blood pressure is a Outcome_Physical, BP is a Outcome_Physical, biofeedback treatment ( BF ) is a Intervention_Psychological, Fifteen is a Participant_Sample-size, white - coat hypertensive is a Participant_Condition, 23 is a Participant_Sample-size, essential hypertensive is a Participant_Condition, visited the clinic is a Intervention_Physical, BPs of white - coat hypertensives and essential hypertensives is a Outcome_Physical, pulse is a Outcome_Physical, respiratory rates is a Outcome_Physical, elevation of diastolic BP due to mental stress testing is a Outcome_Physical	3063_task1	Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please typing these entity words according to sentence: Blood pressure biofeedback treatment, blood pressure, BP, biofeedback treatment ( BF ), Fifteen, white - coat hypertensive, 23, essential hypertensive, visited the clinic, BPs of white - coat hypertensives and essential hypertensives, pulse, respiratory rates, elevation of diastolic BP due to mental stress testing Options: Intervention_Psychological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .	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Blood pressure biofeedback treatment, blood pressure, BP, biofeedback treatment ( BF ), Fifteen, white - coat hypertensive, 23, essential hypertensive, visited the clinic, BPs of white - coat hypertensives and essential hypertensives, pulse, respiratory rates, elevation of diastolic BP due to mental stress testing	3063_task2	Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .	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Prophylactic cranial irradiation is a Intervention_Physical, patients with small - cell lung cancer in complete remission is a Participant_Condition, overall survival . is a Outcome_Mortality, patients in complete remission is a Participant_Condition, prophylactic cranial irradiation is a Intervention_Physical, brain metastasis , overall survival is a Outcome_Mortality, late - occurring toxic effects is a Outcome_Adverse-effects, 300 is a Participant_Sample-size, patients who had small - cell lung cancer that was in complete remission is a Participant_Condition, no prophylactic cranial irradiation ( control group ) is a Intervention_Physical, relapse is a Outcome_Mental, Two hundred ninety - four patients is a Participant_Sample-size, 2-year cumulative rate of brain metastasis is a Outcome_Mental, total 2-year rate of brain metastasis is a Outcome_Physical, 2-year overall survival rate is a Outcome_Mortality, neuropsychological function or abnormalities is a Outcome_Physical, patients who are in complete remission is a Participant_Condition	81986_task0	Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . 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BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .	[ "Prophylactic", "cranial", "irradiation", "for", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "BACKGROUND", "Prophylactic", "cranial", "irradiation", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "decreases", "the", "overall", "rate", "of", "brain", "metastases", "without", "an", "effect", "on", "overall", "survival", ".", "It", "has", "been", "suggested", "that", "this", "treatment", "may", "increase", "neuropsychological", "syndromes", "and", "brain", "abnormalities", "indicated", "by", "computed", "tomography", "scans", ".", "However", ",", "other", "retrospective", "data", "suggested", "a", "beneficial", "effect", "on", "overall", "survival", "for", "patients", "in", "complete", "remission", ".", "PURPOSE", "Our", "purpose", "was", "to", "evaluate", "the", "effects", "of", "prophylactic", "cranial", "irradiation", "on", "brain", "metastasis", ",", "overall", "survival", ",", "and", "late", "-", "occurring", "toxic", "effects", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "METHODS", "We", "conducted", "a", "prospective", "study", "of", "300", "patients", "who", "had", "small", "-", "cell", "lung", "cancer", "that", "was", "in", "complete", "remission", ".", "The", "patients", "were", "randomly", "assigned", "to", "receive", "either", "prophylactic", "cranial", "irradiation", "delivering", "24", "Gy", "in", "eight", "fractions", "during", "12", "days", "(", "treatment", "group", ")", "or", "no", "prophylactic", "cranial", "irradiation", "(", "control", "group", ")", ".", "A", "neuropsychological", "examination", "and", "a", "computed", "tomography", "scan", "of", "the", "brain", "were", "performed", "at", "the", "time", "of", "random", "assignment", "and", "repeatedly", "assessed", "at", "6", ",", "18", ",", "30", ",", "and", "48", "months", ".", "Patterns", "of", "failure", "were", "analyzed", "according", "to", "total", "event", "rates", "and", "also", "according", "to", "an", "isolated", "first", "site", "of", "relapse", ",", "using", "a", "competing", "-", "risk", "approach", ".", "RESULTS", "Two", "hundred", "ninety", "-", "four", "patients", "who", "did", "not", "have", "brain", "metastases", "at", "the", "time", "of", "random", "assignment", "were", "analyzed", ".", "The", "2-year", "cumulative", "rate", "of", "brain", "metastasis", "as", "an", "isolated", "first", "site", "of", "relapse", "was", "45", "%", "in", "the", "control", "group", "and", "19", "%", "in", "the", "treatment", "group", "(", "P", "<", "10", "(", "-6", ")", ")", ".", "The", "total", "2-year", "rate", "of", "brain", "metastasis", "was", "67", "%", "and", "40", "%", ",", "respectively", "(", "relative", "risk", "=", "0.35", ";", "P", "<", "10", "(", "-13", ")", ")", ".", "The", "2-year", "overall", "survival", "rate", "was", "21.5", "%", "in", "the", "control", "group", "and", "29", "%", "in", "the", "treatment", "group", "(", "relative", "risk", "=", "0.83", ";", "P", "=", ".14", ")", ".", "There", "were", "no", "significant", "differences", "between", "the", "two", "groups", "in", "terms", "of", "neuropsychological", "function", "or", "abnormalities", "indicated", "by", "computed", "tomography", "brain", "scans", ".", "CONCLUSIONS", "Prophylactic", "cranial", "irradiation", "given", "to", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", "decreases", "the", "risk", "of", "brain", "metastasis", "threefold", "without", "a", "significant", "increase", "in", "complications", ".", "A", "possible", "beneficial", "effect", "on", "overall", "survival", "should", "be", "tested", "with", "a", "higher", "statistical", "power", ".", "IMPLICATIONS", "The", "results", "of", "the", "trial", "favor", ",", "at", "present", ",", "the", "indication", "of", "prophylactic", "cranial", "irradiation", "for", "patients", "who", "are", "in", "complete", "remission", ".", "A", "longer", "follow", "-", "up", "and", "confirmatory", "trials", "are", "needed", "to", "fully", "assess", "late", "-", "occurring", "toxic", "effects", ".", "The", "possible", "effect", "on", "overall", "survival", "needs", "to", "be", "evaluated", "with", "a", "larger", "number", "of", "patients", "in", "complete", "remission", ",", "and", "a", "meta", "-", "analysis", "of", "similar", "trials", "is", "recommended", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]
Prophylactic cranial irradiation is a Intervention_Physical, patients with small - cell lung cancer in complete remission is a Participant_Condition, overall survival . is a Outcome_Mortality, patients in complete remission is a Participant_Condition, prophylactic cranial irradiation is a Intervention_Physical, brain metastasis , overall survival is a Outcome_Mortality, late - occurring toxic effects is a Outcome_Adverse-effects, 300 is a Participant_Sample-size, patients who had small - cell lung cancer that was in complete remission is a Participant_Condition, no prophylactic cranial irradiation ( control group ) is a Intervention_Physical, relapse is a Outcome_Mental, Two hundred ninety - four patients is a Participant_Sample-size, 2-year cumulative rate of brain metastasis is a Outcome_Mental, total 2-year rate of brain metastasis is a Outcome_Physical, 2-year overall survival rate is a Outcome_Mortality, neuropsychological function or abnormalities is a Outcome_Physical, patients who are in complete remission is a Participant_Condition	81986_task1	Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . Instructions: please typing these entity words according to sentence: Prophylactic cranial irradiation, patients with small - cell lung cancer in complete remission, overall survival ., patients in complete remission, prophylactic cranial irradiation, brain metastasis , overall survival, late - occurring toxic effects, 300, patients who had small - cell lung cancer that was in complete remission, no prophylactic cranial irradiation ( control group ), relapse, Two hundred ninety - four patients, 2-year cumulative rate of brain metastasis, total 2-year rate of brain metastasis, 2-year overall survival rate, neuropsychological function or abnormalities, patients who are in complete remission Options: Outcome_Adverse-effects, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Mental	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .	[ "Prophylactic", "cranial", "irradiation", "for", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "BACKGROUND", "Prophylactic", "cranial", "irradiation", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "decreases", "the", "overall", "rate", "of", "brain", "metastases", "without", "an", "effect", "on", "overall", "survival", ".", "It", "has", "been", "suggested", "that", "this", "treatment", "may", "increase", "neuropsychological", "syndromes", "and", "brain", "abnormalities", "indicated", "by", "computed", "tomography", "scans", ".", "However", ",", "other", "retrospective", "data", "suggested", "a", "beneficial", "effect", "on", "overall", "survival", "for", "patients", "in", "complete", "remission", ".", "PURPOSE", "Our", "purpose", "was", "to", "evaluate", "the", "effects", "of", "prophylactic", "cranial", "irradiation", "on", "brain", "metastasis", ",", "overall", "survival", ",", "and", "late", "-", "occurring", "toxic", "effects", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "METHODS", "We", "conducted", "a", "prospective", "study", "of", "300", "patients", "who", "had", "small", "-", "cell", "lung", "cancer", "that", "was", "in", "complete", "remission", ".", "The", "patients", "were", "randomly", "assigned", "to", "receive", "either", "prophylactic", "cranial", "irradiation", "delivering", "24", "Gy", "in", "eight", "fractions", "during", "12", "days", "(", "treatment", "group", ")", "or", "no", "prophylactic", "cranial", "irradiation", "(", "control", "group", ")", ".", "A", "neuropsychological", "examination", "and", "a", "computed", "tomography", "scan", "of", "the", "brain", "were", "performed", "at", "the", "time", "of", "random", "assignment", "and", "repeatedly", "assessed", "at", "6", ",", "18", ",", "30", ",", "and", "48", "months", ".", "Patterns", "of", "failure", "were", "analyzed", "according", "to", "total", "event", "rates", "and", "also", "according", "to", "an", "isolated", "first", "site", "of", "relapse", ",", "using", "a", "competing", "-", "risk", "approach", ".", "RESULTS", "Two", "hundred", "ninety", "-", "four", "patients", "who", "did", "not", "have", "brain", "metastases", "at", "the", "time", "of", "random", "assignment", "were", "analyzed", ".", "The", "2-year", "cumulative", "rate", "of", "brain", "metastasis", "as", "an", "isolated", "first", "site", "of", "relapse", "was", "45", "%", "in", "the", "control", "group", "and", "19", "%", "in", "the", "treatment", "group", "(", "P", "<", "10", "(", "-6", ")", ")", ".", "The", "total", "2-year", "rate", "of", "brain", "metastasis", "was", "67", "%", "and", "40", "%", ",", "respectively", "(", "relative", "risk", "=", "0.35", ";", "P", "<", "10", "(", "-13", ")", ")", ".", "The", "2-year", "overall", "survival", "rate", "was", "21.5", "%", "in", "the", "control", "group", "and", "29", "%", "in", "the", "treatment", "group", "(", "relative", "risk", "=", "0.83", ";", "P", "=", ".14", ")", ".", "There", "were", "no", "significant", "differences", "between", "the", "two", "groups", "in", "terms", "of", "neuropsychological", "function", "or", "abnormalities", "indicated", "by", "computed", "tomography", "brain", "scans", ".", "CONCLUSIONS", "Prophylactic", "cranial", "irradiation", "given", "to", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", "decreases", "the", "risk", "of", "brain", "metastasis", "threefold", "without", "a", "significant", "increase", "in", "complications", ".", "A", "possible", "beneficial", "effect", "on", "overall", "survival", "should", "be", "tested", "with", "a", "higher", "statistical", "power", ".", "IMPLICATIONS", "The", "results", "of", "the", "trial", "favor", ",", "at", "present", ",", "the", "indication", "of", "prophylactic", "cranial", "irradiation", "for", "patients", "who", "are", "in", "complete", "remission", ".", "A", "longer", "follow", "-", "up", "and", "confirmatory", "trials", "are", "needed", "to", "fully", "assess", "late", "-", "occurring", "toxic", "effects", ".", "The", "possible", "effect", "on", "overall", "survival", "needs", "to", "be", "evaluated", "with", "a", "larger", "number", "of", "patients", "in", "complete", "remission", ",", "and", "a", "meta", "-", "analysis", "of", "similar", "trials", "is", "recommended", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]
Prophylactic cranial irradiation, patients with small - cell lung cancer in complete remission, overall survival ., patients in complete remission, prophylactic cranial irradiation, brain metastasis , overall survival, late - occurring toxic effects, 300, patients who had small - cell lung cancer that was in complete remission, no prophylactic cranial irradiation ( control group ), relapse, Two hundred ninety - four patients, 2-year cumulative rate of brain metastasis, total 2-year rate of brain metastasis, 2-year overall survival rate, neuropsychological function or abnormalities, patients who are in complete remission	81986_task2	Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .	[ "Prophylactic", "cranial", "irradiation", "for", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "BACKGROUND", "Prophylactic", "cranial", "irradiation", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "decreases", "the", "overall", "rate", "of", "brain", "metastases", "without", "an", "effect", "on", "overall", "survival", ".", "It", "has", "been", "suggested", "that", "this", "treatment", "may", "increase", "neuropsychological", "syndromes", "and", "brain", "abnormalities", "indicated", "by", "computed", "tomography", "scans", ".", "However", ",", "other", "retrospective", "data", "suggested", "a", "beneficial", "effect", "on", "overall", "survival", "for", "patients", "in", "complete", "remission", ".", "PURPOSE", "Our", "purpose", "was", "to", "evaluate", "the", "effects", "of", "prophylactic", "cranial", "irradiation", "on", "brain", "metastasis", ",", "overall", "survival", ",", "and", "late", "-", "occurring", "toxic", "effects", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "METHODS", "We", "conducted", "a", "prospective", "study", "of", "300", "patients", "who", "had", "small", "-", "cell", "lung", "cancer", "that", "was", "in", "complete", "remission", ".", "The", "patients", "were", "randomly", "assigned", "to", "receive", "either", "prophylactic", "cranial", "irradiation", "delivering", "24", "Gy", "in", "eight", "fractions", "during", "12", "days", "(", "treatment", "group", ")", "or", "no", "prophylactic", "cranial", "irradiation", "(", "control", "group", ")", ".", "A", "neuropsychological", "examination", "and", "a", "computed", "tomography", "scan", "of", "the", "brain", "were", "performed", "at", "the", "time", "of", "random", "assignment", "and", "repeatedly", "assessed", "at", "6", ",", "18", ",", "30", ",", "and", "48", "months", ".", "Patterns", "of", "failure", "were", "analyzed", "according", "to", "total", "event", "rates", "and", "also", "according", "to", "an", "isolated", "first", "site", "of", "relapse", ",", "using", "a", "competing", "-", "risk", "approach", ".", "RESULTS", "Two", "hundred", "ninety", "-", "four", "patients", "who", "did", "not", "have", "brain", "metastases", "at", "the", "time", "of", "random", "assignment", "were", "analyzed", ".", "The", "2-year", "cumulative", "rate", "of", "brain", "metastasis", "as", "an", "isolated", "first", "site", "of", "relapse", "was", "45", "%", "in", "the", "control", "group", "and", "19", "%", "in", "the", "treatment", "group", "(", "P", "<", "10", "(", "-6", ")", ")", ".", "The", "total", "2-year", "rate", "of", "brain", "metastasis", "was", "67", "%", "and", "40", "%", ",", "respectively", "(", "relative", "risk", "=", "0.35", ";", "P", "<", "10", "(", "-13", ")", ")", ".", "The", "2-year", "overall", "survival", "rate", "was", "21.5", "%", "in", "the", "control", "group", "and", "29", "%", "in", "the", "treatment", "group", "(", "relative", "risk", "=", "0.83", ";", "P", "=", ".14", ")", ".", "There", "were", "no", "significant", "differences", "between", "the", "two", "groups", "in", "terms", "of", "neuropsychological", "function", "or", "abnormalities", "indicated", "by", "computed", "tomography", "brain", "scans", ".", "CONCLUSIONS", "Prophylactic", "cranial", "irradiation", "given", "to", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", "decreases", "the", "risk", "of", "brain", "metastasis", "threefold", "without", "a", "significant", "increase", "in", "complications", ".", "A", "possible", "beneficial", "effect", "on", "overall", "survival", "should", "be", "tested", "with", "a", "higher", "statistical", "power", ".", "IMPLICATIONS", "The", "results", "of", "the", "trial", "favor", ",", "at", "present", ",", "the", "indication", "of", "prophylactic", "cranial", "irradiation", "for", "patients", "who", "are", "in", "complete", "remission", ".", "A", "longer", "follow", "-", "up", "and", "confirmatory", "trials", "are", "needed", "to", "fully", "assess", "late", "-", "occurring", "toxic", "effects", ".", "The", "possible", "effect", "on", "overall", "survival", "needs", "to", "be", "evaluated", "with", "a", "larger", "number", "of", "patients", "in", "complete", "remission", ",", "and", "a", "meta", "-", "analysis", "of", "similar", "trials", "is", "recommended", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]
hypoglossal nerve palsy is an umlsterm, nasal septum is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, distance is an umlsterm, hypoglossal nerve is an umlsterm, surgery is an umlsterm, literature is an umlsterm, palsy is an umlsterm, endotracheal intubation is an umlsterm, use is an umlsterm, laryngeal mask airway is an umlsterm, bronchoscopy is an umlsterm, laryngoscopy is an umlsterm	DerAnaesthesist.70460034.eng.abstr_task0	Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .	[ "Background", ":", "We", "report", "a", "case", "of", "irreversible", "unilateral", "hypoglossal", "nerve", "palsy", "in", "connection", "with", "nasal", "septum", "surgery", "in", "intubation", "anaesthesia", ".", "On", "account", "of", "the", "spatial", "distance", ",", "there", "is", "no", "danger", "of", "injuring", "the", "hypoglossal", "nerve", "during", "nasal", "surgery", ".", "However", ",", "in", "the", "otorhinolaryngological", "and", "anaesthesiological", "literature", ",", "some", "cases", "of", "hypoglossal", "palsy", "following", "endotracheal", "intubation", ",", "use", "of", "the", "laryngeal", "mask", "airway", ",", "bronchoscopy", "and", "laryngoscopy", "are", "reported", "." ]	[ "umlsterm" ]
hypoglossal nerve palsy is an umlsterm, nasal septum is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, distance is an umlsterm, hypoglossal nerve is an umlsterm, surgery is an umlsterm, literature is an umlsterm, palsy is an umlsterm, endotracheal intubation is an umlsterm, use is an umlsterm, laryngeal mask airway is an umlsterm, bronchoscopy is an umlsterm, laryngoscopy is an umlsterm	DerAnaesthesist.70460034.eng.abstr_task1	Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please typing these entity words according to sentence: hypoglossal nerve palsy, nasal septum, surgery, intubation, distance, hypoglossal nerve, surgery, literature, palsy, endotracheal intubation, use, laryngeal mask airway, bronchoscopy, laryngoscopy Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .	[ "Background", ":", "We", "report", "a", "case", "of", "irreversible", "unilateral", "hypoglossal", "nerve", "palsy", "in", "connection", "with", "nasal", "septum", "surgery", "in", "intubation", "anaesthesia", ".", "On", "account", "of", "the", "spatial", "distance", ",", "there", "is", "no", "danger", "of", "injuring", "the", "hypoglossal", "nerve", "during", "nasal", "surgery", ".", "However", ",", "in", "the", "otorhinolaryngological", "and", "anaesthesiological", "literature", ",", "some", "cases", "of", "hypoglossal", "palsy", "following", "endotracheal", "intubation", ",", "use", "of", "the", "laryngeal", "mask", "airway", ",", "bronchoscopy", "and", "laryngoscopy", "are", "reported", "." ]	[ "umlsterm" ]
hypoglossal nerve palsy, nasal septum, surgery, intubation, distance, hypoglossal nerve, surgery, literature, palsy, endotracheal intubation, use, laryngeal mask airway, bronchoscopy, laryngoscopy	DerAnaesthesist.70460034.eng.abstr_task2	Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .	[ "Background", ":", "We", "report", "a", "case", "of", "irreversible", "unilateral", "hypoglossal", "nerve", "palsy", "in", "connection", "with", "nasal", "septum", "surgery", "in", "intubation", "anaesthesia", ".", "On", "account", "of", "the", "spatial", "distance", ",", "there", "is", "no", "danger", "of", "injuring", "the", "hypoglossal", "nerve", "during", "nasal", "surgery", ".", "However", ",", "in", "the", "otorhinolaryngological", "and", "anaesthesiological", "literature", ",", "some", "cases", "of", "hypoglossal", "palsy", "following", "endotracheal", "intubation", ",", "use", "of", "the", "laryngeal", "mask", "airway", ",", "bronchoscopy", "and", "laryngoscopy", "are", "reported", "." ]	[ "umlsterm" ]
contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) is a Intervention_Physical, hydrogel Acuvue 2 ( etafilcon A ) contact lenses is a Intervention_Physical, extended wear ( EW ) is a Participant_Condition, 55 is a Participant_Sample-size, 53 is a Participant_Sample-size, Lipid uptake is a Outcome_Physical, total lipid is a Outcome_Physical, cholesterol esters is a Outcome_Physical, triglycerides / phospholipids is a Outcome_Physical, fatty acid is a Outcome_Physical, ratio of the extracted lipids is a Outcome_Physical, fatty acids / di- and monoglycerides is a Outcome_Physical, Total lipid uptake is a Outcome_Physical, uptake of lipids is a Outcome_Physical	67094_task0	Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . 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PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .	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contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) is a Intervention_Physical, hydrogel Acuvue 2 ( etafilcon A ) contact lenses is a Intervention_Physical, extended wear ( EW ) is a Participant_Condition, 55 is a Participant_Sample-size, 53 is a Participant_Sample-size, Lipid uptake is a Outcome_Physical, total lipid is a Outcome_Physical, cholesterol esters is a Outcome_Physical, triglycerides / phospholipids is a Outcome_Physical, fatty acid is a Outcome_Physical, ratio of the extracted lipids is a Outcome_Physical, fatty acids / di- and monoglycerides is a Outcome_Physical, Total lipid uptake is a Outcome_Physical, uptake of lipids is a Outcome_Physical	67094_task1	Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . 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PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .	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contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ), hydrogel Acuvue 2 ( etafilcon A ) contact lenses, extended wear ( EW ), 55, 53, Lipid uptake, total lipid, cholesterol esters, triglycerides / phospholipids, fatty acid, ratio of the extracted lipids, fatty acids / di- and monoglycerides, Total lipid uptake, uptake of lipids	67094_task2	Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .	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infection is an umlsterm, infection is an umlsterm, signs is an umlsterm, cultures is an umlsterm, inflammation is an umlsterm, Scintigraphy is an umlsterm, white blood cells is an umlsterm, WBC is an umlsterm, diagnosis is an umlsterm, sepsis is an umlsterm, musculoskeletal system is an umlsterm, patients is an umlsterm, infection is an umlsterm, prospectively studied is an umlsterm, Infection is an umlsterm, hip joint prosthesis is an umlsterm, knee joint prosthesis is an umlsterm, shoulder is an umlsterm, joint prosthesis is an umlsterm, All is an umlsterm, WBC is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, infections is an umlsterm, culture is an umlsterm, histologic is an umlsterm, culture is an umlsterm, histologic is an umlsterm, sensitivity is an umlsterm, imaging is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, imaging is an umlsterm, diagnosis is an umlsterm, infection is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm	DerChirurg.70681181.eng.abstr_task0	Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O" ]	When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .	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infection is an umlsterm, infection is an umlsterm, signs is an umlsterm, cultures is an umlsterm, inflammation is an umlsterm, Scintigraphy is an umlsterm, white blood cells is an umlsterm, WBC is an umlsterm, diagnosis is an umlsterm, sepsis is an umlsterm, musculoskeletal system is an umlsterm, patients is an umlsterm, infection is an umlsterm, prospectively studied is an umlsterm, Infection is an umlsterm, hip joint prosthesis is an umlsterm, knee joint prosthesis is an umlsterm, shoulder is an umlsterm, joint prosthesis is an umlsterm, All is an umlsterm, WBC is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, infections is an umlsterm, culture is an umlsterm, histologic is an umlsterm, culture is an umlsterm, histologic is an umlsterm, sensitivity is an umlsterm, imaging is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, imaging is an umlsterm, diagnosis is an umlsterm, infection is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm	DerChirurg.70681181.eng.abstr_task1	Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please typing these entity words according to sentence: infection, infection, signs, cultures, inflammation, Scintigraphy, white blood cells, WBC, diagnosis, sepsis, musculoskeletal system, patients, infection, prospectively studied, Infection, hip joint prosthesis, knee joint prosthesis, shoulder, joint prosthesis, All, WBC, surgery, surgery, infections, culture, histologic, culture, histologic, sensitivity, imaging, patients, rheumatoid arthritis, WBC, imaging, standard, diagnostic, methods, patients, WBC, imaging, standard, diagnostic, methods, imaging, diagnosis, infection, imaging, standard, diagnostic, methods, patients, rheumatoid arthritis Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O" ]	When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .	[ "When", "infection", "of", "implants", "is", "suspected", ",", "optimal", "management", "requires", "accurate", "confirmation", "or", "exclusion", "of", "infection", ".", "However", ",", "in", "spite", "of", "demonstrative", "clinical", "signs", "cultures", "of", "smears", "or", "chemical", "parameters", "of", "inflammation", "frequently", "are", "ambiguous", ".", "Scintigraphy", "with", "indium", "-", "labeled", "white", "blood", "cells", "(", "WBC", ")", "has", "been", "reported", "to", "be", "sensitive", "and", "specific", "in", "the", "diagnosis", "of", "low", "-", "grade", "sepsis", "of", "the", "musculoskeletal", "system", ".", "Twenty", "-", "eight", "patients", "with", "possible", "infection", "were", "prospectively", "studied", ".", "Infection", "was", "suspected", "in", "19", "cases", "with", "total", "hip", "joint", "prosthesis", ",", "14", "cases", "with", "knee", "joint", "prosthesis", "and", "1", "case", "with", "shoulder", "joint", "prosthesis", ".", "All", "of", "them", "underwent", "scanning", "with", "indium-111-labeled", "WBC", "and", "subsequently", "underwent", "surgery", ".", "At", "surgery", "infections", "were", "determined", "by", "means", "of", "culture", "or", "histologic", "results", ".", "When", "correlated", "with", "culture", "and", "histologic", "results", "sensitivity", "of", "111-indium", "-", "WBC", "imaging", "was", "89", "%", ",", "with", "a", "specifity", "of", "67", "%", "and", "a", "predictive", "accuracy", "of", "77", "%", ".", "In", "patients", "with", "rheumatoid", "arthritis", ",", "however", ",", "predictive", "accuracy", "of", "111-indium", "-", "labeled", "WBC", "imaging", "was", "higher", "than", "with", "standard", "diagnostic", "methods", ".", "The", "difference", "was", "statistically", "significant", "(", "P", "0.05", ",", "2-test", ")", ".", "In", "the", "patients", "examined", "as", "a", "whole", ",", "predictive", "accuracy", "of", "111-indium", "-", "labeled", "WBC", "imaging", "does", "not", "differ", "from", "that", "of", "standard", "diagnostic", "methods", ".", "That", "is", "why", "expensive", "and", "time", "-", "consuming", "111-indium", "-", "WBC", "imaging", "is", "not", "justified", "generally", "in", "diagnosis", "of", "infection", "of", "implants", ".", "111-Indium", "-", "WBC", "imaging", "is", "well", "suited", "to", "supplement", "standard", "diagnostic", "methods", "in", "patients", "with", "rheumatoid", "arthritis", "." ]	[ "umlsterm" ]
infection, infection, signs, cultures, inflammation, Scintigraphy, white blood cells, WBC, diagnosis, sepsis, musculoskeletal system, patients, infection, prospectively studied, Infection, hip joint prosthesis, knee joint prosthesis, shoulder, joint prosthesis, All, WBC, surgery, surgery, infections, culture, histologic, culture, histologic, sensitivity, imaging, patients, rheumatoid arthritis, WBC, imaging, standard, diagnostic, methods, patients, WBC, imaging, standard, diagnostic, methods, imaging, diagnosis, infection, imaging, standard, diagnostic, methods, patients, rheumatoid arthritis	DerChirurg.70681181.eng.abstr_task2	Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O" ]	When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .	[ "When", "infection", "of", "implants", "is", "suspected", ",", "optimal", "management", "requires", "accurate", "confirmation", "or", "exclusion", "of", "infection", ".", "However", ",", "in", "spite", "of", "demonstrative", "clinical", "signs", "cultures", "of", "smears", "or", "chemical", "parameters", "of", "inflammation", "frequently", "are", "ambiguous", ".", "Scintigraphy", "with", "indium", "-", "labeled", "white", "blood", "cells", "(", "WBC", ")", "has", "been", "reported", "to", "be", "sensitive", "and", "specific", "in", "the", "diagnosis", "of", "low", "-", "grade", "sepsis", "of", "the", "musculoskeletal", "system", ".", "Twenty", "-", "eight", "patients", "with", "possible", "infection", "were", "prospectively", "studied", ".", "Infection", "was", "suspected", "in", "19", "cases", "with", "total", "hip", "joint", "prosthesis", ",", "14", "cases", "with", "knee", "joint", "prosthesis", "and", "1", "case", "with", "shoulder", "joint", "prosthesis", ".", "All", "of", "them", "underwent", "scanning", "with", "indium-111-labeled", "WBC", "and", "subsequently", "underwent", "surgery", ".", "At", "surgery", "infections", "were", "determined", "by", "means", "of", "culture", "or", "histologic", "results", ".", "When", "correlated", "with", "culture", "and", "histologic", "results", "sensitivity", "of", "111-indium", "-", "WBC", "imaging", "was", "89", "%", ",", "with", "a", "specifity", "of", "67", "%", "and", "a", "predictive", "accuracy", "of", "77", "%", ".", "In", "patients", "with", "rheumatoid", "arthritis", ",", "however", ",", "predictive", "accuracy", "of", "111-indium", "-", "labeled", "WBC", "imaging", "was", "higher", "than", "with", "standard", "diagnostic", "methods", ".", "The", "difference", "was", "statistically", "significant", "(", "P", "0.05", ",", "2-test", ")", ".", "In", "the", "patients", "examined", "as", "a", "whole", ",", "predictive", "accuracy", "of", "111-indium", "-", "labeled", "WBC", "imaging", "does", "not", "differ", "from", "that", "of", "standard", "diagnostic", "methods", ".", "That", "is", "why", "expensive", "and", "time", "-", "consuming", "111-indium", "-", "WBC", "imaging", "is", "not", "justified", "generally", "in", "diagnosis", "of", "infection", "of", "implants", ".", "111-Indium", "-", "WBC", "imaging", "is", "well", "suited", "to", "supplement", "standard", "diagnostic", "methods", "in", "patients", "with", "rheumatoid", "arthritis", "." ]	[ "umlsterm" ]
over 40 years is a Value, Medical examination is a Procedure, prior to participation in research is a Temporal, without is a Negation, history is a Observation, inner ear disease is a Condition	NCT02529475_inc_task0	Sentence: Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years) Informed consent signed Medical examination performed prior to participation in research Patients without history of inner ear disease Recipient of a French social security scheme Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Observation, Procedure, Negation	[ "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Negation", "B-Observation", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years) Informed consent signed Medical examination performed prior to participation in research Patients without history of inner ear disease Recipient of a French social security scheme	[ "Major", "subjects", "of", "over", "40", "years", "(", "mean", "age", "of", "Meniere", "'s", "disease", "40", "to", "50", "years", ")", "\n", "Informed", "consent", "signed", "\n", "Medical", "examination", "performed", "prior", "to", "participation", "in", "research", "\n", "Patients", "without", "history", "of", "inner", "ear", "disease", "\n", "Recipient", "of", "a", "French", "social", "security", "scheme", "\n" ]	[ "Temporal", "Procedure", "Condition", "Value", "Observation", "Negation", "Person" ]

myosin heavy chain is a Individual_protein, actin is a Individual_protein

591_task0

Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]

Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.

[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]

[ "Individual_protein" ]

myosin heavy chain is a Individual_protein, actin is a Individual_protein

591_task1

Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please typing these entity words according to sentence: myosin heavy chain, actin Options: Individual_protein

[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]

Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.

[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]

[ "Individual_protein" ]

myosin heavy chain, actin

591_task2

Sentence: Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]

Photochemical cleavage of myosin heavy chain and the effect on the interaction with actin.

[ "Photochemical", "cleavage", "of", "myosin", "heavy", "chain", "and", "the", "effect", "on", "the", "interaction", "with", "actin", "." ]

[ "Individual_protein" ]

novel gene is a DNA_family_or_group, 3q21 is a DNA_domain_or_region, ecotropic viral insertion site I is a DNA_domain_or_region, leukemia is an other_name

53235_task0

Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, DNA_domain_or_region, other_name

[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]

Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.

[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]

[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]

novel gene is a DNA_family_or_group, 3q21 is a DNA_domain_or_region, ecotropic viral insertion site I is a DNA_domain_or_region, leukemia is an other_name

53235_task1

Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please typing these entity words according to sentence: novel gene, 3q21, ecotropic viral insertion site I, leukemia Options: DNA_family_or_group, DNA_domain_or_region, other_name

[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]

Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.

[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]

[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]

novel gene, 3q21, ecotropic viral insertion site I, leukemia

53235_task2

Sentence: Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "O", "B-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "O" ]

Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.

[ "Activation", "of", "a", "novel", "gene", "in", "3q21", "and", "identification", "of", "intergenic", "fusion", "transcripts", "with", "ecotropic", "viral", "insertion", "site", "I", "in", "leukemia", "." ]

[ "DNA_domain_or_region", "other_name", "tissue", "cell_line", "RNA_family_or_group", "DNA_family_or_group" ]

Heparin plus dipyridamole is a Intervention_Pharmacological, childhood is a Participant_Age, hemolytic - uremic syndrome is a Participant_Condition, 58 is a Participant_Sample-size, infants and children is a Participant_Age, heparin and dipyridamole is a Intervention_Pharmacological, incidence of anuria is a Outcome_Physical, faster recovery from hypertension is a Outcome_Physical, incidence and severity of the histologic lesions is a Outcome_Physical, blood pressure is a Outcome_Physical, creatinine clearance values is a Outcome_Physical, benefit over symptomatic therapy is a Outcome_Other

75054_task0

Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Age, Participant_Sample-size, Outcome_Other

[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]

Heparin plus dipyridamole is a Intervention_Pharmacological, childhood is a Participant_Age, hemolytic - uremic syndrome is a Participant_Condition, 58 is a Participant_Sample-size, infants and children is a Participant_Age, heparin and dipyridamole is a Intervention_Pharmacological, incidence of anuria is a Outcome_Physical, faster recovery from hypertension is a Outcome_Physical, incidence and severity of the histologic lesions is a Outcome_Physical, blood pressure is a Outcome_Physical, creatinine clearance values is a Outcome_Physical, benefit over symptomatic therapy is a Outcome_Other

75054_task1

Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please typing these entity words according to sentence: Heparin plus dipyridamole, childhood, hemolytic - uremic syndrome, 58, infants and children, heparin and dipyridamole, incidence of anuria, faster recovery from hypertension, incidence and severity of the histologic lesions, blood pressure, creatinine clearance values, benefit over symptomatic therapy Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Age, Participant_Sample-size, Outcome_Other

[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]

Heparin plus dipyridamole, childhood, hemolytic - uremic syndrome, 58, infants and children, heparin and dipyridamole, incidence of anuria, faster recovery from hypertension, incidence and severity of the histologic lesions, blood pressure, creatinine clearance values, benefit over symptomatic therapy

75054_task2

Sentence: Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Age", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Intervention_Physical", "Participant_Sample-size" ]

neoplasia is a MORFOLOGIA_NEOPLASIA, tumor de células germinales ( TCG ) mixto is a MORFOLOGIA_NEOPLASIA, carcinoma embrionario is a MORFOLOGIA_NEOPLASIA, teratoma is a MORFOLOGIA_NEOPLASIA, tumor del seno endodérmico is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, lesión retroperitoneal is a MORFOLOGIA_NEOPLASIA, lesiones pulmonares is a MORFOLOGIA_NEOPLASIA, nódulos pulmonares is a MORFOLOGIA_NEOPLASIA, masa retroperitoneal is a MORFOLOGIA_NEOPLASIA, teratoma maduro is a MORFOLOGIA_NEOPLASIA, micronódulos pulmonares is a MORFOLOGIA_NEOPLASIA

109_task0

Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.

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[ "MORFOLOGIA_NEOPLASIA" ]

neoplasia is a MORFOLOGIA_NEOPLASIA, tumor de células germinales ( TCG ) mixto is a MORFOLOGIA_NEOPLASIA, carcinoma embrionario is a MORFOLOGIA_NEOPLASIA, teratoma is a MORFOLOGIA_NEOPLASIA, tumor del seno endodérmico is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, lesión retroperitoneal is a MORFOLOGIA_NEOPLASIA, lesiones pulmonares is a MORFOLOGIA_NEOPLASIA, nódulos pulmonares is a MORFOLOGIA_NEOPLASIA, masa retroperitoneal is a MORFOLOGIA_NEOPLASIA, teratoma maduro is a MORFOLOGIA_NEOPLASIA, micronódulos pulmonares is a MORFOLOGIA_NEOPLASIA

109_task1

Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. Instructions: please typing these entity words according to sentence: neoplasia, tumor de células germinales ( TCG ) mixto, carcinoma embrionario, teratoma, tumor del seno endodérmico, nódulo pulmonar, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a, nódulo pulmonar, tumoral, lesión retroperitoneal, lesiones pulmonares, nódulos pulmonares, masa retroperitoneal, teratoma maduro, micronódulos pulmonares Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.

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[ "MORFOLOGIA_NEOPLASIA" ]

neoplasia, tumor de células germinales ( TCG ) mixto, carcinoma embrionario, teratoma, tumor del seno endodérmico, nódulo pulmonar, tumor de células germinales no seminomatoso ( TCGNS ) T2 N3 M1a, nódulo pulmonar, tumoral, lesión retroperitoneal, lesiones pulmonares, nódulos pulmonares, masa retroperitoneal, teratoma maduro, micronódulos pulmonares

109_task2

Sentence: Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales. Instructions: please extract entity words from the input sentence

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Anamnesis Paciente varón de 40 años de edad, fumador (índice paquetes/año de 20), sin otros antecedentes personales ni familiares de interés (no criptorquidia ni otros antecedentes urológicos) que consulta en agosto del año 2013 por un cuadro de 3 meses de evolución consistente en aumento del tamaño testicular derecho, sin traumatismo previo, sin otra sintomatología asociada. Exploración física La exploración física en ese momento revelaba un importante aumento de tamaño del testículo referido de hasta 8 cm, sin otras anomalías en el testículo contralateral ni en el resto de la exploración física. Pruebas complementarias » Como parte del estudio inicial se realizó una ecografía escrotal, que objetivó la presencia de una gran masa sólida heterogénea, vascularizada y con zonas quísticas en su interior, ocupando todo el testículo derecho. » Analíticamente, destacaba la presencia de una alfa-fetoproteína (AFP) de 5.494 ng/ml (límites normales [LN] entre 0,6 y 8,5 ng/ml), una fracción beta de la gonadotropina coriónica humana (BHCG) de 126,3 mU/ml (LN entre 0,1 y 4) y lactato deshidrogenasa (LDH) de 293 U/l (LN entre 135 y 225 U/l). Diagnóstico Ante la sospecha diagnóstica de neoplasia testicular, se realizó una orquiectomía derecha vía inguinal el 14/8/2013. La anatomía patológica de la pieza quirúrgica fue informada como tumor de células germinales (TCG) mixto, compuesto por carcinoma embrionario (40%), teratoma (40%) y tumor del seno endodérmico (20%), con infiltración de todo el parénquima testicular, rete testis y epidídimo sin superar la albugínea, aunque con imágenes de infiltración linfática y venosa. Como parte del estudio de extensión se realizó una tomografía computarizada (TC) toracoabdominopélvica, objetivando la presencia de un gran conglomerado adenopático de 8 x 10 x 8,7 cm (ejes longitudinal, anteroposterior y transverso, respectivamente) y un nódulo pulmonar de 1,2 cm en la língula. Los marcadores tumorales postquirúrgicos eran AFP 4.164 ng/ml, beta-hCG 113,2 mU/ml y la LDH en ese momento era de 318. Tratamiento Con el diagnóstico de tumor de células germinales no seminomatoso (TCGNS) T2 N3 M1a S2, estadio IIIb (AJCC de 2002), de pronóstico intermedio según la clasificación de la IGCCCG (International Germ Cell Cancer Collaborative Group), se propuso inicio de tratamiento quimioterápico con BEP (bleomicina 30 mg semanal durante 12 semanas, etopósido 100 mg/m2 días 1 a 5 y cisplatino 20 mg/m2 días 1 a 5), recibiendo tres ciclos de BEP y 1 ciclo EP con buena tolerancia, presentando como toxicidades mucositis grado 1 y un episodio de neutropenia grado 3 afebril que condicionó un retraso de siete días en el inicio del tercer ciclo. Evolución En la TC de reevaluación tras tres ciclos de quimioterapia se objetivaba respuesta parcial del conglomerado adenopático retroperitoneal (5,6 x 7 x 7,6 cm) y del nódulo pulmonar (en ese momento de 0,8 cm de diámetro). En cuanto a los marcadores tumorales, aunque inicialmente presentaron un descenso adecuado, tras finalizar el tratamiento planeado persistía una elevación de la AFP (niveles de 258 ng/ml) con normalización de B-hCG y LDH. Ante la presencia de enfermedad tumoral residual y elevación persistente de los niveles de AFP, se plantea nueva línea de tratamiento esquema TIP (paclitaxel 175 mg/m2 día 1, ifosfamida 1.000 mg/m2/d días 1-5 y cisplatino 20 mg/m2/d días 1-5) con movilización de células CD34+ y aféresis. Tras los dos ciclos se objetivó respuesta parcial radiológica y bioquímica, por lo que el 4 de marzo de 2014 inicia quimioterapia a altas dosis (QAD) (paclitaxel 175 mg/m2 el día 1, carboplatino AUC 20 (área bajo la curva) y etopósido 1.500 mg/m2 repartidos en 6 dosis cada 12 horas) y posterior infusión de precursores hematopoyéticos. Como complicaciones del tratamiento, presentó mucositis grado 3 y diarrea grado 2; anemia grado 3 y trombopenia grado 4, que requirieron soporte con hemoderivados, así como neutropenia febril grado 4 sin aislamientos microbiológicos que requirió tratamiento empírico con antibiótico de amplio espectro. Tras la recuperación, se repitió una segunda dosis de QAD con soporte autólogo de progenitores hematopoyéticos. En la TC de reevaluación se objetivó persistencia de la lesión retroperitoneal, pero con aparición de nuevas lesiones pulmonares bilaterales milimétricas y ascenso progresivo de la AFP hasta 50 ng/ml. Ante los datos de progresión de la enfermedad, se solicitó tratamiento con etopósido oral (50 mg/m2 al día) como uso compasivo, que inició en mayo de 2014. Con ello se consiguió la negativización de los marcadores tumorales, la disminución de tamaño de los nódulos pulmonares y la estabilidad de la masa retroperitoneal. El paciente fue derivado al Servicio de Urología, realizándose resección del conglomerado retroperitoneal el día 24 de octubre de 2014. La anatomía patológica y la inmunohistoquímica de la pieza quirúrgica fue congruente con teratoma maduro, sin evidencia de otros componentes. Desde entonces el paciente mantiene tratamiento con etopósido oral diario, con buena tolerancia. Actualmente continúa en seguimiento, persistiendo la negatividad de los marcadores tumorales y sin evidencia de recidiva de la enfermedad en las pruebas de imagen. Mantiene micronódulos pulmonares bibasales.

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"y", "cisplatino", "20", "mg", "/", "m2", "días", "1", "a", "5", ")", ",", "recibiendo", "tres", "ciclos", "de", "BEP", "y", "1", "ciclo", "EP", "con", "buena", "tolerancia", ",", "presentando", "como", "toxicidades", "mucositis", "grado", "1", "y", "un", "episodio", "de", "neutropenia", "grado", "3", "afebril", "que", "condicionó", "un", "retraso", "de", "siete", "días", "en", "el", "inicio", "del", "tercer", "ciclo", ".", "\n\n", "Evolución", "\n", "En", "la", "TC", "de", "reevaluación", "tras", "tres", "ciclos", "de", "quimioterapia", "se", "objetivaba", "respuesta", "parcial", "del", "conglomerado", "adenopático", "retroperitoneal", "(", "5,6", "x", "7", "x", "7,6", "cm", ")", "y", "del", "nódulo", "pulmonar", "(", "en", "ese", "momento", "de", "0,8", "cm", "de", "diámetro", ")", ".", "En", "cuanto", "a", "los", "marcadores", "tumorales", ",", "aunque", "inicialmente", "presentaron", "un", "descenso", "adecuado", ",", "tras", "finalizar", "el", "tratamiento", "planeado", "persistía", "una", "elevación", "de", "la", "AFP", "(", "niveles", "de", "258", "ng", "/", "ml", ")", "con", "normalización", "de", "B", "-", "hCG", "y", "LDH", ".", "\n\n", "Ante", "la", "presencia", "de", "enfermedad", "tumoral", "residual", "y", "elevación", "persistente", "de", "los", "niveles", "de", "AFP", ",", "se", "plantea", "nueva", "línea", "de", "tratamiento", "esquema", "TIP", "(", "paclitaxel", "175", "mg", "/", "m2", "día", "1", ",", "ifosfamida", "1.000", "mg", "/", "m2", "/", "d", "días", "1", "-", "5", "y", "cisplatino", "20", "mg", "/", "m2", "/", "d", "días", "1", "-", "5", ")", "con", "movilización", "de", "células", "CD34", "+", "y", "aféresis", ".", "Tras", "los", "dos", "ciclos", "se", "objetivó", "respuesta", "parcial", "radiológica", "y", "bioquímica", ",", "por", "lo", "que", "el", "4", "de", "marzo", "de", "2014", "inicia", "quimioterapia", "a", "altas", "dosis", "(", "QAD", ")", "(", "paclitaxel", "175", "mg", "/", "m2", "el", "día", "1", ",", "carboplatino", "AUC", "20", "(", "área", "bajo", "la", "curva", ")", "y", "etopósido", "1.500", "mg", "/", "m2", "repartidos", "en", "6", "dosis", "cada", "12", "horas", ")", "y", "posterior", "infusión", "de", "precursores", "hematopoyéticos", ".", "Como", "complicaciones", "del", "tratamiento", ",", "presentó", "mucositis", "grado", "3", "y", "diarrea", "grado", "2", ";", "anemia", "grado", "3", "y", "trombopenia", "grado", "4", ",", "que", "requirieron", "soporte", "con", "hemoderivados", ",", "así", "como", "neutropenia", "febril", "grado", "4", "sin", "aislamientos", "microbiológicos", "que", "requirió", "tratamiento", "empírico", "con", "antibiótico", "de", "amplio", "espectro", ".", "Tras", "la", "recuperación", ",", "se", "repitió", "una", "segunda", "dosis", "de", "QAD", "con", "soporte", "autólogo", "de", "progenitores", "hematopoyéticos", ".", "\n\n", "En", "la", "TC", "de", "reevaluación", "se", "objetivó", "persistencia", "de", "la", "lesión", "retroperitoneal", ",", "pero", "con", "aparición", "de", "nuevas", "lesiones", "pulmonares", "bilaterales", "milimétricas", "y", "ascenso", "progresivo", "de", "la", "AFP", "hasta", "50", "ng", "/", "ml", ".", "\n\n", "Ante", "los", "datos", "de", "progresión", "de", "la", "enfermedad", ",", "se", "solicitó", "tratamiento", "con", "etopósido", "oral", "(", "50", "mg", "/", "m2", "al", "día", ")", "como", "uso", "compasivo", ",", "que", "inició", "en", "mayo", "de", "2014", ".", "Con", "ello", "se", "consiguió", "la", "negativización", "de", "los", "marcadores", "tumorales", ",", "la", "disminución", "de", "tamaño", "de", "los", "nódulos", "pulmonares", "y", "la", "estabilidad", "de", "la", "masa", "retroperitoneal", ".", "\n\n", "El", "paciente", "fue", "derivado", "al", "Servicio", "de", "Urología", ",", "realizándose", "resección", "del", "conglomerado", "retroperitoneal", "el", "día", "24", "de", "octubre", "de", "2014", ".", "La", "anatomía", "patológica", "y", "la", "inmunohistoquímica", "de", "la", "pieza", "quirúrgica", "fue", "congruente", "con", "teratoma", "maduro", ",", "sin", "evidencia", "de", "otros", "componentes", ".", "\n\n", "Desde", "entonces", "el", "paciente", "mantiene", "tratamiento", "con", "etopósido", "oral", "diario", ",", "con", "buena", "tolerancia", ".", "Actualmente", "continúa", "en", "seguimiento", ",", "persistiendo", "la", "negatividad", "de", "los", "marcadores", "tumorales", "y", "sin", "evidencia", "de", "recidiva", "de", "la", "enfermedad", "en", "las", "pruebas", "de", "imagen", ".", "Mantiene", "micronódulos", "pulmonares", "bibasales", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

IL-4 is a GENE-Y, CXCL-8 is a GENE-Y, E - selectin is a GENE-Y, VEGF is a GENE-Y, inducible nitric oxide synthase is a GENE-Y

17494951_task0

Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]

IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.

[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

IL-4 is a GENE-Y, CXCL-8 is a GENE-Y, E - selectin is a GENE-Y, VEGF is a GENE-Y, inducible nitric oxide synthase is a GENE-Y

17494951_task1

Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please typing these entity words according to sentence: IL-4, CXCL-8, E - selectin, VEGF, inducible nitric oxide synthase Options: GENE-Y

[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]

IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.

[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

IL-4, CXCL-8, E - selectin, VEGF, inducible nitric oxide synthase

17494951_task2

Sentence: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Instructions: please extract entity words from the input sentence

[ "B-GENE-Y", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O" ]

IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells.

[ "IL-4", "stimulates", "the", "expression", "of", "CXCL-8", ",", "E", "-", "selectin", ",", "VEGF", ",", "and", "inducible", "nitric", "oxide", "synthase", "mRNA", "by", "equine", "pulmonary", "artery", "endothelial", "cells", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

outpatient treatment is an umlsterm, detoxification is an umlsterm, psychiatric hospitals is an umlsterm, link is an umlsterm, detoxification is an umlsterm, inpatient treatment is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, motivation is an umlsterm, patients is an umlsterm, treatment is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, treatment is an umlsterm, goal is an umlsterm, treatment is an umlsterm, inpatients is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, period is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, behavior is an umlsterm, patients is an umlsterm, probability is an umlsterm

DerNervenarzt.70680574.eng.abstr_task0

Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .

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[ "umlsterm" ]

outpatient treatment is an umlsterm, detoxification is an umlsterm, psychiatric hospitals is an umlsterm, link is an umlsterm, detoxification is an umlsterm, inpatient treatment is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, motivation is an umlsterm, patients is an umlsterm, treatment is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, treatment is an umlsterm, goal is an umlsterm, treatment is an umlsterm, inpatients is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, treatment is an umlsterm, patients is an umlsterm, alcoholism is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, period is an umlsterm, inpatient is an umlsterm, detoxification is an umlsterm, motivation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, behavior is an umlsterm, patients is an umlsterm, probability is an umlsterm

DerNervenarzt.70680574.eng.abstr_task1

Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please typing these entity words according to sentence: outpatient treatment, detoxification, psychiatric hospitals, link, detoxification, inpatient treatment, inpatient, detoxification, motivation, therapy, motivation, patients, treatment, alcoholism, treatment, patients, treatment, goal, treatment, inpatients, patients, alcoholism, treatment, patients, alcoholism, therapy, treatment, detoxification, motivation, therapy, period, inpatient, detoxification, motivation, therapy, treatment, behavior, patients, probability Options: umlsterm

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In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .

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[ "umlsterm" ]

outpatient treatment, detoxification, psychiatric hospitals, link, detoxification, inpatient treatment, inpatient, detoxification, motivation, therapy, motivation, patients, treatment, alcoholism, treatment, patients, treatment, goal, treatment, inpatients, patients, alcoholism, treatment, patients, alcoholism, therapy, treatment, detoxification, motivation, therapy, period, inpatient, detoxification, motivation, therapy, treatment, behavior, patients, probability

DerNervenarzt.70680574.eng.abstr_task2

Sentence: In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence . Instructions: please extract entity words from the input sentence

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In addition to psychiatric outpatient treatment , the detoxification of alcoholics in psychiatric hospitals is an important link between medical detoxification and psychosocial inpatient treatment aiming at abstinence . Integrated models of inpatient detoxification and motivation therapy focus on improvement of the motivation of patients towards further treatment of their alcoholism and towards abstinence . In our study 529 alcoholics underwent such treatment lasting between 2 to 3 weeks . A total of 469 patients ( 89% ) were followed up after 8 months ; 242 alcoholics ( 52% of the follow-up sample ; 46% of the whole sample ) achieved the treatment goal and started further treatment , mainly as inpatients . Fifty-four of these patients relapsed before they started further alcoholism treatment , but achieved abstinence afterwards ; 60 ( 25% ) of these 242 patients relapsed after the specific alcoholism therapy ; 227 alcoholics did not start further treatment after the initial detoxification and motivation therapy . In this subpopulation , 113 ( 50% ) relapsed during the follow-up period . Although this is not a controlled study , it can be concluded that integrated inpatient detoxification and motivation therapy has positive effects on the treatment behavior of alcoholic patients and enhances the probability of further abstinence .

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[ "umlsterm" ]

actin is a Individual_protein, myosin heavy chain is a Individual_protein

218_task0

Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]

Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.

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[ "Individual_protein" ]

actin is a Individual_protein, myosin heavy chain is a Individual_protein

218_task1

Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please typing these entity words according to sentence: actin, myosin heavy chain Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]

Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.

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[ "Individual_protein" ]

actin, myosin heavy chain

218_task2

Sentence: Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O" ]

Cytoplasmic staining included stress fibers that colocalized with actin, probably as a consequence of the myosin heavy chain component of the fusion protein.

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[ "Individual_protein" ]

Children is an umlsterm, occurrence is an umlsterm, hypothermia is an umlsterm, temperature is an umlsterm, general anaesthesia is an umlsterm, regulation is an umlsterm, adults is an umlsterm, heating is an umlsterm, devices is an umlsterm, children is an umlsterm, surgery is an umlsterm

DerAnaesthesist.80470475.eng.abstr_task0

Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .

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[ "umlsterm" ]

Children is an umlsterm, occurrence is an umlsterm, hypothermia is an umlsterm, temperature is an umlsterm, general anaesthesia is an umlsterm, regulation is an umlsterm, adults is an umlsterm, heating is an umlsterm, devices is an umlsterm, children is an umlsterm, surgery is an umlsterm

DerAnaesthesist.80470475.eng.abstr_task1

Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please typing these entity words according to sentence: Children, occurrence, hypothermia, temperature, general anaesthesia, regulation, adults, heating, devices, children, surgery Options: umlsterm

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Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .

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[ "umlsterm" ]

Children, occurrence, hypothermia, temperature, general anaesthesia, regulation, adults, heating, devices, children, surgery

DerAnaesthesist.80470475.eng.abstr_task2

Sentence: Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery . Instructions: please extract entity words from the input sentence

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Children are very sensible to the occurrence of intraoperative hypothermia ( HT ) ( core temperature =36 . 0 C ) during general anaesthesia because their regulation capacity is less effective than in adults and due to a large skin-surface area compared with their body mass . We compared the efficacy of different heating devices to prevent HT in children during surgery .

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[ "umlsterm" ]

Early educational intervention is a Intervention_Educational, very low birth weight infants : is a Participant_Condition, Infant Health and Development Program . is a Intervention_Educational, early educational intervention is a Intervention_Educational, very low birth weight ( < or = 1500 gm ) infants . is a Participant_Condition, follow - up only is a Intervention_Control, intensive pediatric and developmental surveillance . is a Intervention_Educational, received home visits and center - based educational interventions is a Intervention_Educational, Cognitive development ( Stanford - Binet Intelligence Scale ) is a Outcome_Mental, behavioral competence ( Achebach Child Behavior Checklist ) is a Outcome_Mental, health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) is a Outcome_Physical, Cognitive development scores is a Outcome_Physical, neonatal morbidity is a Outcome_Physical, behavior , serious morbidity , functional status , or health rating is a Outcome_Physical, lower behavior problem scores is a Outcome_Physical, rates of less serious morbidity . is a Outcome_Physical

81866_task0

Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Participant_Condition, Intervention_Educational, Outcome_Physical, Outcome_Mental

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Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .

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[ "Outcome_Physical", "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Control" ]

Early educational intervention is a Intervention_Educational, very low birth weight infants : is a Participant_Condition, Infant Health and Development Program . is a Intervention_Educational, early educational intervention is a Intervention_Educational, very low birth weight ( < or = 1500 gm ) infants . is a Participant_Condition, follow - up only is a Intervention_Control, intensive pediatric and developmental surveillance . is a Intervention_Educational, received home visits and center - based educational interventions is a Intervention_Educational, Cognitive development ( Stanford - Binet Intelligence Scale ) is a Outcome_Mental, behavioral competence ( Achebach Child Behavior Checklist ) is a Outcome_Mental, health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) is a Outcome_Physical, Cognitive development scores is a Outcome_Physical, neonatal morbidity is a Outcome_Physical, behavior , serious morbidity , functional status , or health rating is a Outcome_Physical, lower behavior problem scores is a Outcome_Physical, rates of less serious morbidity . is a Outcome_Physical

81866_task1

Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please typing these entity words according to sentence: Early educational intervention, very low birth weight infants :, Infant Health and Development Program ., early educational intervention, very low birth weight ( < or = 1500 gm ) infants ., follow - up only, intensive pediatric and developmental surveillance ., received home visits and center - based educational interventions, Cognitive development ( Stanford - Binet Intelligence Scale ), behavioral competence ( Achebach Child Behavior Checklist ), health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ), Cognitive development scores, neonatal morbidity, behavior , serious morbidity , functional status , or health rating, lower behavior problem scores, rates of less serious morbidity . Options: Intervention_Control, Participant_Condition, Intervention_Educational, Outcome_Physical, Outcome_Mental

[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .

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[ "Outcome_Physical", "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Control" ]

Early educational intervention, very low birth weight infants :, Infant Health and Development Program ., early educational intervention, very low birth weight ( < or = 1500 gm ) infants ., follow - up only, intensive pediatric and developmental surveillance ., received home visits and center - based educational interventions, Cognitive development ( Stanford - Binet Intelligence Scale ), behavioral competence ( Achebach Child Behavior Checklist ), health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ), Cognitive development scores, neonatal morbidity, behavior , serious morbidity , functional status , or health rating, lower behavior problem scores, rates of less serious morbidity .

81866_task2

Sentence: Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Early educational intervention for very low birth weight infants : results from the Infant Health and Development Program . OBJECTIVE To examine the effect of early educational intervention after discharge from the hospital on the health and developmental status of very low birth weight ( < or = 1500 gm ) infants . DESIGN Randomized , controlled trial , with post hoc analysis . SETTING Eight sites , heterogeneous for sociodemographic and health care use . PARTICIPANTS Infants ( N = 280 ) born weighing < or = 1500 gm and selected for the Infant Health and Development Program . Eligibility was limited primarily by geographic distance from the day care center . One third were randomly assigned to the intervention ( INT ) group and two thirds to follow-up only . INTERVENTIONS All children received intensive pediatric and developmental surveillance . The INT group received home visits and center-based educational interventions until 36 months of age ( corrected for gestational age when final assessments were completed ) . OUTCOMES Cognitive development ( Stanford-Binet Intelligence Scale ) , behavioral competence ( Achebach Child Behavior Checklist ) , and health status ( indexes summarizing reported morbidity , the Functional Status II ( R ) Scale , and General Health Ratings Index ) . RESULTS Cognitive development scores were 7.2 points higher ( p = 0.002 ) in the INT group , after adjustment for baseline differences in site , sociodemographic characteristics , and neonatal morbidity , and were 9.4 points higher ( p < 0.0003 ) when the 29 children with significant cerebral palsy were removed . No differences in behavior , serious morbidity , functional status , or health rating were found overall . The infants in the INT group who weighted < or = 1000 gm at birth had significantly lower behavior problem scores but no differences on other outcomes . All children in the INT group had slightly higher rates of less serious morbidity . CONCLUSION The advantage conferred by being in the INT group , as previously reported for heavier infants , extends to very low birth weight children , supporting the use of early intervention in this group .

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[ "Outcome_Physical", "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Control" ]

rotundic acid is a CHEMICAL

23558236_task0

Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]

Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.

[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]

[ "CHEMICAL", "GENE-Y" ]

rotundic acid is a CHEMICAL

23558236_task1

Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please typing these entity words according to sentence: rotundic acid Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]

Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.

[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]

[ "CHEMICAL", "GENE-Y" ]

rotundic acid

23558236_task2

Sentence: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O" ]

Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives.

[ "Design", ",", "synthesis", "and", "cytotoxicity", "of", "cell", "death", "mechanism", "of", "rotundic", "acid", "derivatives", "." ]

[ "CHEMICAL", "GENE-Y" ]

age is a Person, < 45 or > 80 is a Value, allergies is a Condition, medications is a Drug, used in the study is a Qualifier, history is a Observation, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse is a Scope, definite is a Qualifier, radiographic evidence is a Mood, osteoarthritis is a Condition, glenohumeral joint is a Qualifier, inflammatory arthritis is a Condition, rheumatoid arthritis is a Condition, history is a Observation, acute trauma is a Condition, systemic conditions is a Condition, associated with chronic pain is a Qualifier, history is a Observation, infection is a Condition, inability to understand the questionnaires is a Observation

NCT02992028_exc_task0

Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Observation, Scope, Mood, Drug

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]

age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires

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[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]

age is a Person, < 45 or > 80 is a Value, allergies is a Condition, medications is a Drug, used in the study is a Qualifier, history is a Observation, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse is a Scope, definite is a Qualifier, radiographic evidence is a Mood, osteoarthritis is a Condition, glenohumeral joint is a Qualifier, inflammatory arthritis is a Condition, rheumatoid arthritis is a Condition, history is a Observation, acute trauma is a Condition, systemic conditions is a Condition, associated with chronic pain is a Qualifier, history is a Observation, infection is a Condition, inability to understand the questionnaires is a Observation

NCT02992028_exc_task1

Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please typing these entity words according to sentence: age, < 45 or > 80, allergies, medications, used in the study, history, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse, definite, radiographic evidence, osteoarthritis, glenohumeral joint, inflammatory arthritis, rheumatoid arthritis, history, acute trauma, systemic conditions, associated with chronic pain, history, infection, inability to understand the questionnaires Options: Condition, Qualifier, Value, Person, Observation, Scope, Mood, Drug

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]

age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires

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[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]

age, < 45 or > 80, allergies, medications, used in the study, history, renal diseases , a coagulation abnormality , a hepatic disease , or drug abuse, definite, radiographic evidence, osteoarthritis, glenohumeral joint, inflammatory arthritis, rheumatoid arthritis, history, acute trauma, systemic conditions, associated with chronic pain, history, infection, inability to understand the questionnaires

NCT02992028_exc_task2

Sentence: age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires Instructions: please extract entity words from the input sentence

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Condition", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Observation", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "B-Mood", "I-Mood", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Observation", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Observation", "O", "B-Condition", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]

age <45 or >80 allergies to medications used in the study history of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse definite radiographic evidence of osteoarthritis of the glenohumeral joint inflammatory arthritis including rheumatoid arthritis a history of acute trauma systemic conditions associated with chronic pain a history of infection an inability to understand the questionnaires

[ "age", "<", "45", "or", ">", "80", "\n", "allergies", "to", "medications", "used", "in", "the", "study", "\n", "history", "of", "renal", "diseases", ",", "a", "coagulation", "abnormality", ",", "a", "hepatic", "disease", ",", "or", "drug", "abuse", "\n", "definite", "radiographic", "evidence", "of", "osteoarthritis", "of", "the", "glenohumeral", "joint", "\n", "inflammatory", "arthritis", "including", "rheumatoid", "arthritis", "\n", "a", "history", "of", "acute", "trauma", "\n", "systemic", "conditions", "associated", "with", "chronic", "pain", "\n", "a", "history", "of", "infection", "\n", "an", "inability", "to", "understand", "the", "questionnaires", "\n" ]

[ "Scope", "Observation", "Qualifier", "Condition", "Mood", "Procedure", "Drug", "Value", "Person" ]

non - cystic fibrosis bronchiectasis is a Condition, high - resolution CT is a Procedure, sensitive is a Condition, amikacin is a Drug, Acute exacerbation of bronchiectasis is a Condition

NCT02509091_inc_task0

Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Procedure, Drug

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.

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[ "Condition", "Value", "Procedure", "Drug", "Person" ]

non - cystic fibrosis bronchiectasis is a Condition, high - resolution CT is a Procedure, sensitive is a Condition, amikacin is a Drug, Acute exacerbation of bronchiectasis is a Condition

NCT02509091_inc_task1

Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please typing these entity words according to sentence: non - cystic fibrosis bronchiectasis, high - resolution CT, sensitive, amikacin, Acute exacerbation of bronchiectasis Options: Condition, Procedure, Drug

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.

[ "Age=18", "years", "and", "=", "80", "years", ";", "\n", "Patients", "with", "non", "-", "cystic", "fibrosis", "bronchiectasis", "diagnosed", "by", "high", "-", "resolution", "CT", ";", "\n", "Are", "sensitive", "to", "amikacin", ";", "\n", "Acute", "exacerbation", "of", "bronchiectasis", ";", "\n", "Capable", "of", "the", "completion", "of", "bronchoscopy", ",", "alveolar", "lavage", ",", "pulmonary", "function", "testing", "etc", ";", "\n", "Willing", "to", "join", "in", "and", "sign", "the", "informed", "consent", "form", ".", "\n" ]

[ "Condition", "Value", "Procedure", "Drug", "Person" ]

non - cystic fibrosis bronchiectasis, high - resolution CT, sensitive, amikacin, Acute exacerbation of bronchiectasis

NCT02509091_inc_task2

Sentence: Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age=18 years and =80 years; Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT; Are sensitive to amikacin; Acute exacerbation of bronchiectasis; Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc; Willing to join in and sign the informed consent form.

[ "Age=18", "years", "and", "=", "80", "years", ";", "\n", "Patients", "with", "non", "-", "cystic", "fibrosis", "bronchiectasis", "diagnosed", "by", "high", "-", "resolution", "CT", ";", "\n", "Are", "sensitive", "to", "amikacin", ";", "\n", "Acute", "exacerbation", "of", "bronchiectasis", ";", "\n", "Capable", "of", "the", "completion", "of", "bronchoscopy", ",", "alveolar", "lavage", ",", "pulmonary", "function", "testing", "etc", ";", "\n", "Willing", "to", "join", "in", "and", "sign", "the", "informed", "consent", "form", ".", "\n" ]

[ "Condition", "Value", "Procedure", "Drug", "Person" ]

Interferon - gamma is a protein_molecule, antiviral activity is an other_name, interferon - stimulated genes is a DNA_family_or_group, interferon - alpha in U937 cells is a cell_line

88913_task0

Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, other_name, cell_line, protein_molecule

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]

Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.

[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]

[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]

Interferon - gamma is a protein_molecule, antiviral activity is an other_name, interferon - stimulated genes is a DNA_family_or_group, interferon - alpha in U937 cells is a cell_line

88913_task1

Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please typing these entity words according to sentence: Interferon - gamma, antiviral activity, interferon - stimulated genes, interferon - alpha in U937 cells Options: DNA_family_or_group, other_name, cell_line, protein_molecule

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]

Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.

[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]

[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]

Interferon - gamma, antiviral activity, interferon - stimulated genes, interferon - alpha in U937 cells

88913_task2

Sentence: Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. Instructions: please extract entity words from the input sentence

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-other_name", "I-other_name", "O", "O", "O", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "I-cell_line", "O" ]

Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.

[ "Interferon", "-", "gamma", "potentiates", "the", "antiviral", "activity", "and", "the", "expression", "of", "interferon", "-", "stimulated", "genes", "induced", "by", "interferon", "-", "alpha", "in", "U937", "cells", "." ]

[ "protein_family_or_group", "other_name", "DNA_domain_or_region", "cell_line", "protein_molecule", "DNA_family_or_group", "cell_type", "cell_component", "RNA_molecule" ]

Radiotherapie is an umlsterm, malignen Melanom is an umlsterm, Prognosefaktoren is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Patienten is an umlsterm, Histologie is an umlsterm, Melanoms is an umlsterm, Histologie is an umlsterm, Patienten is an umlsterm, Rezidivtumoren is an umlsterm, Tumorrest is an umlsterm, Patienten is an umlsterm, Lymphknoten- is an umlsterm, Fernmetastasen is an umlsterm, Erstdiagnose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Analyse is an umlsterm, Kopf - Hals - Bereich is an umlsterm, multivariater Analyse is an umlsterm, Prognosefaktor is an umlsterm, Tumorkontrolle is an umlsterm, Tumorkontrolle is an umlsterm

DerHautarzt.90500572.ger.abstr_task0

Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .

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[ "umlsterm" ]

Radiotherapie is an umlsterm, malignen Melanom is an umlsterm, Prognosefaktoren is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Patienten is an umlsterm, Histologie is an umlsterm, Melanoms is an umlsterm, Histologie is an umlsterm, Patienten is an umlsterm, Rezidivtumoren is an umlsterm, Tumorrest is an umlsterm, Patienten is an umlsterm, Lymphknoten- is an umlsterm, Fernmetastasen is an umlsterm, Erstdiagnose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Analyse is an umlsterm, Kopf - Hals - Bereich is an umlsterm, multivariater Analyse is an umlsterm, Prognosefaktor is an umlsterm, Tumorkontrolle is an umlsterm, Tumorkontrolle is an umlsterm

DerHautarzt.90500572.ger.abstr_task1

Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . Instructions: please typing these entity words according to sentence: Radiotherapie, malignen Melanom, Prognosefaktoren, Patienten, Frauen, Maenner, Patienten, Histologie, Melanoms, Histologie, Patienten, Rezidivtumoren, Tumorrest, Patienten, Lymphknoten-, Fernmetastasen, Erstdiagnose, Patienten, Patienten, Patienten, Patienten, Patienten, Analyse, Kopf - Hals - Bereich, multivariater Analyse, Prognosefaktor, Tumorkontrolle, Tumorkontrolle Options: umlsterm

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Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .

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[ "umlsterm" ]

Radiotherapie, malignen Melanom, Prognosefaktoren, Patienten, Frauen, Maenner, Patienten, Histologie, Melanoms, Histologie, Patienten, Rezidivtumoren, Tumorrest, Patienten, Lymphknoten-, Fernmetastasen, Erstdiagnose, Patienten, Patienten, Patienten, Patienten, Patienten, Analyse, Kopf - Hals - Bereich, multivariater Analyse, Prognosefaktor, Tumorkontrolle, Tumorkontrolle

DerHautarzt.90500572.ger.abstr_task2

Sentence: Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv . Instructions: please extract entity words from the input sentence

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Diese Studie stellt 20 Jahre klinische Erfahrungen mit der Radiotherapie ( RT ) beim lokal fortgeschrittenen , rezidivierten und metastasierten malignen Melanom ( MM ) vor und untersucht dabei verschiedene Endpunkte und Prognosefaktoren . Von 1977 bis 1995 wurde bei 121 Patienten ( 56 Frauen , 65 Maenner ) aus 2917 Patienten des lokalen MM-Registers eine palliative RT bei fortgeschrittenem MM indiziert . Die Histologie des primaeren Melanoms war nodulaer ( n=51), superfiziell spreitend n=35), akral-lentiginoes ( ( n=8) oder vom lentigo maligna Typ ( n=4); bei 22 fehlte die primaere Histologie oder sie war nicht klar zuzuordnen . Elf Patienten mit Primaer- oder Rezidivtumoren waren inoperabel oder wiesen einen makroskopischen Tumorrest ( R2) nach Resektion auf UICC IIB ) ; ( 57 Patienten hatten Lymphknoten- n=33) oder In-transit-Metastasen ( n=24) ( UICC III ) ; 53 ( hatten Fernmetastasen ( 7 M 1a und 46 M 1b , UICC IV ) . Das Intervall von der Erstdiagnose bis zum RT-Beginn betrug im Mittel 19 ( median : 18 ; Spanne 3-186 ) Monate . Es wurde eine mittlere Gesamtdosis von 45 ( median : 48 ; Spanne 20-66 ) Gy appliziert . Eine komplettes und/oder partielles Ansprechen ( CR/CR+PR) nach 3 Monaten erreichten 7 ( 64% ) bzw. alle ( 100% ) Patienten im Stadium UICC IIB , 25 ( 44% ) /44 ( 77% ) im Stadium UICC III , und 9 ( 17% ) /26 ( 49% ) im Stadium UICC IV . Progredient waren 25 21% ) ( Patienten . Patienten mit CR ueberlebten laenger ( median : 40 Monate ) als ohne CR ( 10 Monate ) ( p 0,01 ) . Am Stichtag ( 31.12.1996 ) lebten noch 26 Patienten : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , 3 ( 6% ) UICC IV Patienten ( p 0,01 ) . In univariater Analyse ergaben sich fuer die Endpunkte CR und Ueberleben folgende prognostisch guenstige Faktoren : niedriges UICC Stadium ( p 0,001 ) , Lokalisation im Kopf-Hals-Bereich , Gesamtdosis > 40 Gy ( alle p 0,05 ) . In multivariater Analyse war das UICC Stadium der einzige unabhaengige guenstige Prognosefaktor fuer das Erreichen einer CR und das langfristige Ueberleben ( p 0,001 ) . Die perkutane RT erzielt nicht nur eine effektive Palliation , sondern auch eine langfristige Tumorkontrolle beim MM im UICC Stadium IIB-IV . Das aktuelle UICC-Staging-System ist nicht nur initial , sondern auch bei der Metastasierung fuer die initiale und langfristige Tumorkontrolle praediktiv .

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[ "umlsterm" ]

Stimulationsimpedanz is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwert is an umlsterm, Langzeitverlauf is an umlsterm, Patienten is an umlsterm, Impedanzaenderungen is an umlsterm, Implantations- is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwerte is an umlsterm, Implantationswert is an umlsterm, Impedanz is an umlsterm, Impedanzwerten is an umlsterm, Impedanzwerte is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Impedanzwerten is an umlsterm, Patienten is an umlsterm, Impedanzen is an umlsterm, Stimulanzimpedanz is an umlsterm, Patienten is an umlsterm, Stimulationsimpedanz is an umlsterm

ZfuerKardiologie.80870022.ger.abstr_task0

Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .

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[ "umlsterm" ]

Stimulationsimpedanz is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwert is an umlsterm, Langzeitverlauf is an umlsterm, Patienten is an umlsterm, Impedanzaenderungen is an umlsterm, Implantations- is an umlsterm, Impedanzwerte is an umlsterm, Impedanzwerte is an umlsterm, Implantationswert is an umlsterm, Impedanz is an umlsterm, Impedanzwerten is an umlsterm, Impedanzwerte is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Impedanzwerten is an umlsterm, Patienten is an umlsterm, Impedanzen is an umlsterm, Stimulanzimpedanz is an umlsterm, Patienten is an umlsterm, Stimulationsimpedanz is an umlsterm

ZfuerKardiologie.80870022.ger.abstr_task1

Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . Instructions: please typing these entity words according to sentence: Stimulationsimpedanz, Impedanzwerte, Impedanzwert, Langzeitverlauf, Patienten, Impedanzaenderungen, Implantations-, Impedanzwerte, Impedanzwerte, Implantationswert, Impedanz, Impedanzwerten, Impedanzwerte, Patienten, Patienten, Impedanzwerten, Patienten, Impedanzen, Stimulanzimpedanz, Patienten, Stimulationsimpedanz Options: umlsterm

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Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .

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[ "umlsterm" ]

Stimulationsimpedanz, Impedanzwerte, Impedanzwert, Langzeitverlauf, Patienten, Impedanzaenderungen, Implantations-, Impedanzwerte, Impedanzwerte, Implantationswert, Impedanz, Impedanzwerten, Impedanzwerte, Patienten, Patienten, Impedanzwerten, Patienten, Impedanzen, Stimulanzimpedanz, Patienten, Stimulationsimpedanz

ZfuerKardiologie.80870022.ger.abstr_task2

Sentence: Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen . Instructions: please extract entity words from the input sentence

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Da sich die Stimulationsimpedanz invers zum Stimulationsstrom verhaelt , senken hohe Impedanzwerte bei gleichbleibenden Stimulationsimpulsen zusaetzlich den Stimulationsstrom . Inwieweit der intraoperativ gemessene Impedanzwert der Ventrikelstimulation repraesentativ fuer den Langzeitverlauf ist , wurde bei 87 Patienten untersucht , die die VDD-Einzelelektrode UniPass 425 und den Schrittmacher Unity ( Sulzer Intermedics ) erhalten hatten . Es wurden die Impedanzaenderungen zwischen Implantations- und 6-Monats-Zeitpunkt ermittelt . Als gleiche Impedanzwerte wurde definiert , wenn beide Messwerte = +/- 100 voneinander abwichen . Kleinere bzw. groessere Impedanzwerte lagen 6 Monate nach Implantation vor , wenn sie sich > +/- 100 vom Implantationswert unterschieden . Intraoperativ betrug die Impedanz 535 +/- 98 ( Spannweite : 333-811 ) und war nach 6 Monaten signifikant auf 604 +/- 160 ( Spannweite : 361-1150 ) angestiegen . Der Unterschied zwischen den beiden Impedanzwerten betrug 69 +/- 162 ( Spannweite : -336 bis +560 ) . Gleiche Impedanzwerte lagen bei 43 ( Implantation : 527 +/- 75 , 6 Monate : 531 +/- 87 kleinere ) , bei 11 ( Implantation : 660 +/- 83 6 Monate : , 494 +/- 73 ) und groessere bei 33 Patienten ( Implantation : 503 +/- 99 , 6 Monate : 735 +/- 168 ) vor . Im Vergleich zu den Patienten mit gleichbleibenden Impedanzwerten hatten Patienten mit niedrigeren Impedanzen bei Implantation signifikant hoehere Ausgangswerte . Schlussfolgerungen : Die Stimulanzimpedanz nimmt im Laufe von 6 Monaten nach Implantation signifikant zu . Bei 51% der Patienten kommt es zu deutlichen Veraenderungen der Stimulationsimpedanz . Diese lassen sich in der Tendenz , aber nicht im Einzelfall voraussagen .

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[ "umlsterm" ]

volunteers is a Participant_Sample-size, prospective Le Fort I osteotomy is a Participant_Condition, multi - media tablet device delivering both graphic and verbal information is a Intervention_Educational, audio device delivering essentially the same information in verbal form only is a Intervention_Educational, efficiencies is a Outcome_Other, ability to recall the information is a Outcome_Mental

63913_task0

Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]

volunteers is a Participant_Sample-size, prospective Le Fort I osteotomy is a Participant_Condition, multi - media tablet device delivering both graphic and verbal information is a Intervention_Educational, audio device delivering essentially the same information in verbal form only is a Intervention_Educational, efficiencies is a Outcome_Other, ability to recall the information is a Outcome_Mental

63913_task1

Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please typing these entity words according to sentence: volunteers, prospective Le Fort I osteotomy, multi - media tablet device delivering both graphic and verbal information, audio device delivering essentially the same information in verbal form only, efficiencies, ability to recall the information Options: Participant_Condition, Intervention_Educational, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]

volunteers, prospective Le Fort I osteotomy, multi - media tablet device delivering both graphic and verbal information, audio device delivering essentially the same information in verbal form only, efficiencies, ability to recall the information

63913_task2

Sentence: Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method . Instructions: please extract entity words from the input sentence

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Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy . This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications . The aim of the study was to compare two methods of information delivery ; a multi-media tablet device delivering both graphic and verbal information , and an audio device delivering essentially the same information in verbal form only . The null hypothesis was that there would be no difference between the efficiencies of the two methods . The subjects ' ability to recall the information delivered by both devices was assessed using a questionnaire . The tablet device participants scored an average of 15.48 points , while the audio device participants scored an average of 268 points . The difference was statistically significant ( p < 0.001 ) , suggesting that the multi-media tablet device was more effective method .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Outcome_Other", "Participant_Sample-size" ]

Biopsien is an umlsterm, Therapieverfahren is an umlsterm, MR - Tomographie is an umlsterm, MR - Tomographie is an umlsterm, Zeit is an umlsterm, MR - Tomographie is an umlsterm, Radiologie is an umlsterm, Therapie is an umlsterm

DerRadiologe.90390741.ger.abstr_task0

Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .

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[ "umlsterm" ]

Biopsien is an umlsterm, Therapieverfahren is an umlsterm, MR - Tomographie is an umlsterm, MR - Tomographie is an umlsterm, Zeit is an umlsterm, MR - Tomographie is an umlsterm, Radiologie is an umlsterm, Therapie is an umlsterm

DerRadiologe.90390741.ger.abstr_task1

Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please typing these entity words according to sentence: Biopsien, Therapieverfahren, MR - Tomographie, MR - Tomographie, Zeit, MR - Tomographie, Radiologie, Therapie Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .

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[ "umlsterm" ]

Biopsien, Therapieverfahren, MR - Tomographie, MR - Tomographie, Zeit, MR - Tomographie, Radiologie, Therapie

DerRadiologe.90390741.ger.abstr_task2

Sentence: Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird . Instructions: please extract entity words from the input sentence

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Das Spektrum MR-gefuehrter Eingriffe reicht von Biopsien , thermischen Therapieverfahren , vaskulaeren Applikationen bis hin zum intraoperativen Einsatz der MR-Tomographie . Das Konzept der Steuerung durch die MR-Tomographie basiert auf der Kombination von exzellenter morphologischer und funktioneller Bildgebung . Die wichtigsten in letzter Zeit vorgelegten experimentellen und klinischen Ergebnisse werden diskutiert . Es ist davon auszugehen , dass die interventionelle MR-Tomographie einen hohen Stellenwert im Bereich der interventionellen Radiologie , der minimal-invasiven Therapie und der Ueberwachung von operativen Eingriffen erlangen wird .

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[ "umlsterm" ]

Patienten is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Verletzungen is an umlsterm, Trauma is an umlsterm, Rollenabbrueche is an umlsterm, Frakturen is an umlsterm, Fraktur is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, postoperative Behandlung is an umlsterm, Fusssohlenkontaktbelastung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Patienten is an umlsterm, Langzeitresultate is an umlsterm

DerChirurg.70680072.ger.abstr_task0

Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .

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[ "umlsterm" ]

Patienten is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Verletzungen is an umlsterm, Trauma is an umlsterm, Rollenabbrueche is an umlsterm, Frakturen is an umlsterm, Fraktur is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, postoperative Behandlung is an umlsterm, Fusssohlenkontaktbelastung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Patienten is an umlsterm, Langzeitresultate is an umlsterm

DerChirurg.70680072.ger.abstr_task1

Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please typing these entity words according to sentence: Patienten, Frakturen, Patienten, Verletzungen, Trauma, Rollenabbrueche, Frakturen, Fraktur, Patienten, Frakturen, postoperative Behandlung, Fusssohlenkontaktbelastung, Patienten, Patienten, Patienten, Patient, Patienten, Langzeitresultate Options: umlsterm

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Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .

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[ "umlsterm" ]

Patienten, Frakturen, Patienten, Verletzungen, Trauma, Rollenabbrueche, Frakturen, Fraktur, Patienten, Frakturen, postoperative Behandlung, Fusssohlenkontaktbelastung, Patienten, Patienten, Patienten, Patient, Patienten, Langzeitresultate

DerChirurg.70680072.ger.abstr_task2

Sentence: Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Zusammenfassung . 29 Patienten mit moncondylaeren Frakturen des distalen Femurs wurden zwischen 1981 und 1994 im Bergmannsheil Bochum behandelt . Alle Patienten erlitten ihre Verletzungen von direktem Trauma . Es handelte sich um 16 laterale Condylenfrakturen , 7 mediale Condylenfrakturen und in 6 Faellen waren tangenitale Rollenabbrueche ( Hoffa-Frakturen ) vorhanden . 28 Frakturen waren geschlossen , und eine Fraktur war drittgradig offen . Elf Patienten erlitten Begleitverletzungen des musculoskelettaeren Systems . Alle Frakturen wurden mit offener anatomischer Reposition und stabiler interner Fixation mit Spongiosazugschrauben behandelt . Die postoperative Behandlung beinhaltete fruehe passive Bewegung auf der Elektroschiene und Fusssohlenkontaktbelastung fuer 6-8 Wochen . Der durchschnittliche Nachuntersuchungszeitraum betrug 68 Monate . Die Behandlungsergebnisse wurden nach dem Neer-Score bewertet . 27 von 29 Patienten konnten nachuntersucht werden . 23 Patienten hatten ein exzellentes Resultat , 3 Patienten ein befriedigendes Resultat , 1 Patient hatte ein unbefriedigendes Resultat . Alle Patienten ohne exzellentes Resultat hatten Begleitverletzungen . Die offene anatomische Reposition und interne Schraubenfixation bei monocondylaeren Femurfrakturen sorgt bei Monoverletzungen fuer hervorragende Langzeitresultate .

[ "Zusammenfassung", ".", "29", "Patienten", "mit", "moncondylaeren", "Frakturen", "des", "distalen", "Femurs", "wurden", "zwischen", "1981", "und", "1994", "im", "Bergmannsheil", "Bochum", "behandelt", ".", "Alle", "Patienten", "erlitten", "ihre", "Verletzungen", "von", "direktem", "Trauma", ".", "Es", "handelte", "sich", "um", "16", "laterale", "Condylenfrakturen", ",", "7", "mediale", "Condylenfrakturen", "und", "in", "6", "Faellen", "waren", "tangenitale", "Rollenabbrueche", "(", "Hoffa", "-", "Frakturen", ")", "vorhanden", ".", "28", "Frakturen", "waren", "geschlossen", ",", "und", "eine", "Fraktur", "war", "drittgradig", "offen", ".", "Elf", "Patienten", "erlitten", "Begleitverletzungen", "des", "musculoskelettaeren", "Systems", ".", "Alle", "Frakturen", "wurden", "mit", "offener", "anatomischer", "Reposition", "und", "stabiler", "interner", "Fixation", "mit", "Spongiosazugschrauben", "behandelt", ".", "Die", "postoperative", "Behandlung", "beinhaltete", "fruehe", "passive", "Bewegung", "auf", "der", "Elektroschiene", "und", "Fusssohlenkontaktbelastung", "fuer", "6", "-", "8", "Wochen", ".", "Der", "durchschnittliche", "Nachuntersuchungszeitraum", "betrug", "68", "Monate", ".", "Die", "Behandlungsergebnisse", "wurden", "nach", "dem", "Neer", "-", "Score", "bewertet", ".", "27", "von", "29", "Patienten", "konnten", "nachuntersucht", "werden", ".", "23", "Patienten", "hatten", "ein", "exzellentes", "Resultat", ",", "3", "Patienten", "ein", "befriedigendes", "Resultat", ",", "1", "Patient", "hatte", "ein", "unbefriedigendes", "Resultat", ".", "Alle", "Patienten", "ohne", "exzellentes", "Resultat", "hatten", "Begleitverletzungen", ".", "Die", "offene", "anatomische", "Reposition", "und", "interne", "Schraubenfixation", "bei", "monocondylaeren", "Femurfrakturen", "sorgt", "bei", "Monoverletzungen", "fuer", "hervorragende", "Langzeitresultate", "." ]

[ "umlsterm" ]

Myosin is an umlsterm

DerGynaekologe.00330344.ger.abstr_task0

Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .

[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]

[ "umlsterm" ]

Myosin is an umlsterm

DerGynaekologe.00330344.ger.abstr_task1

Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please typing these entity words according to sentence: Myosin Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .

[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]

[ "umlsterm" ]

Myosin

DerGynaekologe.00330344.ger.abstr_task2

Sentence: Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Bisher bestehen keine nennenswerten molekularen Kenntnisse ueber den ultrastrukturellen Aufbau des Myometriums ; es konnte lediglich das kontraktile Filamentsystem Aktin und Myosin nachgewiesen werden .

[ "Bisher", "bestehen", "keine", "nennenswerten", "molekularen", "Kenntnisse", "ueber", "den", "ultrastrukturellen", "Aufbau", "des", "Myometriums", ";", "es", "konnte", "lediglich", "das", "kontraktile", "Filamentsystem", "Aktin", "und", "Myosin", "nachgewiesen", "werden", "." ]

[ "umlsterm" ]

RCC1 is a protein, serine is a compound, cdc2 is a protein

DS.d365_task0

Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]

Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.

[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]

[ "compound", "protein" ]

RCC1 is a protein, serine is a compound, cdc2 is a protein

DS.d365_task1

Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please typing these entity words according to sentence: RCC1, serine, cdc2 Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]

Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.

[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]

[ "compound", "protein" ]

RCC1, serine, cdc2

DS.d365_task2

Sentence: Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O" ]

Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.

[ "Ran", "GTPase", "guanine", "nucleotide", "exchange", "factor", "RCC1", "is", "phosphorylated", "on", "serine", "11", "by", "cdc2", "kinase", "in", "vitro", "." ]

[ "compound", "protein" ]

psychotherapy is an umlsterm, psychoanalytic therapy is an umlsterm, hand is an umlsterm, guidelines is an umlsterm, hand is an umlsterm, self - conception is an umlsterm, psychotherapy is an umlsterm, conflicts is an umlsterm, psychotherapy is an umlsterm, distance is an umlsterm, psychoanalytic therapy is an umlsterm, development is an umlsterm, psychotherapy is an umlsterm

ForumDerPsychoanalyse.80140258.eng.abstr_task0

Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .

[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]

[ "umlsterm" ]

psychotherapy is an umlsterm, psychoanalytic therapy is an umlsterm, hand is an umlsterm, guidelines is an umlsterm, hand is an umlsterm, self - conception is an umlsterm, psychotherapy is an umlsterm, conflicts is an umlsterm, psychotherapy is an umlsterm, distance is an umlsterm, psychoanalytic therapy is an umlsterm, development is an umlsterm, psychotherapy is an umlsterm

ForumDerPsychoanalyse.80140258.eng.abstr_task1

Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please typing these entity words according to sentence: psychotherapy, psychoanalytic therapy, hand, guidelines, hand, self - conception, psychotherapy, conflicts, psychotherapy, distance, psychoanalytic therapy, development, psychotherapy Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .

[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]

[ "umlsterm" ]

psychotherapy, psychoanalytic therapy, hand, guidelines, hand, self - conception, psychotherapy, conflicts, psychotherapy, distance, psychoanalytic therapy, development, psychotherapy

ForumDerPsychoanalyse.80140258.eng.abstr_task2

Sentence: Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Up till now psychoanalytic psychotherapy confronted itself not very often with the challenges of quality assurance . Moreover , in the rare articles about this topic the specific characteristics of psychoanalytic therapy were not considered . The reasons for this strained relationship are on the one hand the difficulties between the conceptual guidelines of quality assurance and on the other hand the self-conception of psychoanalytic psychotherapy and inner conflicts of psycho-analytic psychotherapy revived through quality assurance . These problems lead to lack of interest and distance of the psychoanalytic therapy towards quality assur-ance . In case of unavoidable confrontation intense aggressive affects emerge , which impair the institutional self-assertion and the further conceptual development of psychoanalytic psychotherapy .

[ "Up", "till", "now", "psychoanalytic", "psychotherapy", "confronted", "itself", "not", "very", "often", "with", "the", "challenges", "of", "quality", "assurance", ".", "Moreover", ",", "in", "the", "rare", "articles", "about", "this", "topic", "the", "specific", "characteristics", "of", "psychoanalytic", "therapy", "were", "not", "considered", ".", "The", "reasons", "for", "this", "strained", "relationship", "are", "on", "the", "one", "hand", "the", "difficulties", "between", "the", "conceptual", "guidelines", "of", "quality", "assurance", "and", "on", "the", "other", "hand", "the", "self", "-", "conception", "of", "psychoanalytic", "psychotherapy", "and", "inner", "conflicts", "of", "psycho", "-", "analytic", "psychotherapy", "revived", "through", "quality", "assurance", ".", "These", "problems", "lead", "to", "lack", "of", "interest", "and", "distance", "of", "the", "psychoanalytic", "therapy", "towards", "quality", "assur", "-", "ance", ".", "In", "case", "of", "unavoidable", "confrontation", "intense", "aggressive", "affects", "emerge", ",", "which", "impair", "the", "institutional", "self", "-", "assertion", "and", "the", "further", "conceptual", "development", "of", "psychoanalytic", "psychotherapy", "." ]

[ "umlsterm" ]

Psoriasis is an umlsterm, Entzuendung is an umlsterm, Tiermodellen is an umlsterm, Psoriasispathogenese is an umlsterm, Tiermodellen is an umlsterm, Psoriasis is an umlsterm, Elemente is an umlsterm, Transplantationsmodell is an umlsterm

DerHautarzt.70480707.ger.abstr_task0

Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .

[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]

[ "umlsterm" ]

Psoriasis is an umlsterm, Entzuendung is an umlsterm, Tiermodellen is an umlsterm, Psoriasispathogenese is an umlsterm, Tiermodellen is an umlsterm, Psoriasis is an umlsterm, Elemente is an umlsterm, Transplantationsmodell is an umlsterm

DerHautarzt.70480707.ger.abstr_task1

Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please typing these entity words according to sentence: Psoriasis, Entzuendung, Tiermodellen, Psoriasispathogenese, Tiermodellen, Psoriasis, Elemente, Transplantationsmodell Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .

[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]

[ "umlsterm" ]

Psoriasis, Entzuendung, Tiermodellen, Psoriasispathogenese, Tiermodellen, Psoriasis, Elemente, Transplantationsmodell

DerHautarzt.70480707.ger.abstr_task2

Sentence: Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Das fuer die Psoriasis charakteristische Nebeneinander von Entzuendung und epidermaler Hyperproliferation konnte mittlerweile in mehreren Tiermodellen unter Verfolgung unterschiedlicher Strategien reproduziert werden . Diese Modelle gewaehren punktuell Einblick in die multifaktorielle Psoriasispathogenese . Basierend auf den in Tiermodellen erhobenen Befunden wird eine Hypothese zur Pathogenese der Psoriasis vorgeschlagen , deren Elemente sich in einem juengst etablierten xenogenen Transplantationsmodell ueberpruefen lassen .

[ "Das", "fuer", "die", "Psoriasis", "charakteristische", "Nebeneinander", "von", "Entzuendung", "und", "epidermaler", "Hyperproliferation", "konnte", "mittlerweile", "in", "mehreren", "Tiermodellen", "unter", "Verfolgung", "unterschiedlicher", "Strategien", "reproduziert", "werden", ".", "Diese", "Modelle", "gewaehren", "punktuell", "Einblick", "in", "die", "multifaktorielle", "Psoriasispathogenese", ".", "Basierend", "auf", "den", "in", "Tiermodellen", "erhobenen", "Befunden", "wird", "eine", "Hypothese", "zur", "Pathogenese", "der", "Psoriasis", "vorgeschlagen", ",", "deren", "Elemente", "sich", "in", "einem", "juengst", "etablierten", "xenogenen", "Transplantationsmodell", "ueberpruefen", "lassen", "." ]

[ "umlsterm" ]

colágeno is a PROTEINAS, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, CD 68 is a PROTEINAS, Tc 99 m difosfato is a NORMALIZABLES, corticoides is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES

191_task0

Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS

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Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.

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[ "NORMALIZABLES", "PROTEINAS" ]

colágeno is a PROTEINAS, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, CD 68 is a PROTEINAS, Tc 99 m difosfato is a NORMALIZABLES, corticoides is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES, metilprednisolona is a NORMALIZABLES, Urbason is a NORMALIZABLES

191_task1

Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. Instructions: please typing these entity words according to sentence: colágeno, metilprednisolona, Urbason, CD 68, Tc 99 m difosfato, corticoides, metilprednisolona, Urbason, metilprednisolona, Urbason Options: NORMALIZABLES, PROTEINAS

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Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.

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[ "NORMALIZABLES", "PROTEINAS" ]

colágeno, metilprednisolona, Urbason, CD 68, Tc 99 m difosfato, corticoides, metilprednisolona, Urbason, metilprednisolona, Urbason

191_task2

Sentence: Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable. Instructions: please extract entity words from the input sentence

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Paciente mujer de 26 años que acudió a nuestro servicio por edema bilateral de párpados superiores, de 2 años de evolución. En la exploración oftalmológica se observaban, en la parte nasal de ambos párpados superiores, lesiones de límites imprecisos (aspecto infiltrante de la epidermis), con tonalidad anaranjada en la zona temporal, de consistencia firme, y que se extendían a lo largo del pliegue palpebral. Eran masas no móviles ni dolorosas, que no superaban el reborde orbitario. El resto de la exploración era normal. Para intentar realizar diagnóstico diferencial entre entidades como pseudotumor orbitario, enfermedad del colágeno, sarcoidosis, etc., se realizó una exploración sistémica, resultando todos los estudios normales. En la Resonancia Nuclear Magnética (RNM) de órbita realizada, dichas masas eran prácticamente simétricas y llegaban a infiltrar el músculo elevador del párpado superior, sin afectación del globo ocular. Se instauró tratamiento corticoideo (pensando en un proceso inflamatorio localizado a nivel palpebral), con dosis elevadas de metilprednisolona (1 gr de Urbason®, HOECHST FARMA), que hicieron disminuir el tamaño de las tumoraciones pero con recidiva de las mismas al suspender dicha medicación. Ante esto, y al no haber llegado a un diagnóstico, se realizó una biopsia incisional, obteniendo tres piezas de tejido de coloración rosado-amarillento. El estudio histológico mostró tejido conectivo laxo que en su práctica totalidad se encontraba infiltrado por células histiocitarias características de la xantogranulomatosis, que tendían a formar un patrón granulomatoso. Las tinciones inmunohistoquímicas para células histiocitarias (CD 68) resultaron positivas. Con todo esto se llegó al diagnóstico de xantogranulomatosis palpebral. Se realizaron más pruebas para descartar afectación multiorgánica: TC abdomino-torácico, TC craneal y orbitario, Rx torácica, ecografía abdomino-pélvica y Scan óseo con Tc 99m difosfato. Todas fueron normales. Es, por tanto, un caso de xantogranulomatosis, o enfermedad de Erdheim-Chester, orbitaria pura sin manifestaciones sistémicas. En la actualidad, tras un nuevo ciclo de corticoides (metilprednisolona 80 mg/24 horas, Urbason®) y con una dosis de mantenimiento (metilprednisolona 4 mg/48 horas, Urbason®) de forma continua, el proceso permanece relativamente estable.

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[ "NORMALIZABLES", "PROTEINAS" ]

anticholinergic drugs is a GROUP, anticholinergic drugs is a GROUP, decongestants is a GROUP, anesthetics is a GROUP, sympathomimetic amine is a GROUP, epinephrine is a DRUG, norepinephrine is a DRUG, tricyclic antidepressants is a GROUP, imipramine hydrochloride is a DRUG, Imipramine hydrochloride is a DRUG, CNS depressant drugs is a GROUP, imipramine is a DRUG, cimetidine is a DRUG, fluoxetine is a DRUG, barbiturates is a GROUP, phenytoin is a DRUG, imipramine is a DRUG, tricyclic antidepressants is a GROUP, TCAs is a GROUP, TCA is a GROUP, TCA is a GROUP, quinidine is a DRUG, cimetidine is a DRUG, antidepressants is a GROUP, phenothiazines is a GROUP, Type 1C antiarrhythmics is a GROUP, propafenone is a DRUG, flecainide is a DRUG, selective serotonin reuptake inhibitors is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, sertraline is a DRUG, paroxetine is a DRUG, SSRI is a GROUP, TCA is a GROUP, SSRI is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, tricyclic antidepressants is a GROUP, tricyclic antidepressant is a GROUP, tricyclic antidepressant is a GROUP, TCA is a GROUP, TCA is a GROUP

Imipramine_ddi_task0

Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG

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In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.

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[ "GROUP", "DRUG" ]

anticholinergic drugs is a GROUP, anticholinergic drugs is a GROUP, decongestants is a GROUP, anesthetics is a GROUP, sympathomimetic amine is a GROUP, epinephrine is a DRUG, norepinephrine is a DRUG, tricyclic antidepressants is a GROUP, imipramine hydrochloride is a DRUG, Imipramine hydrochloride is a DRUG, CNS depressant drugs is a GROUP, imipramine is a DRUG, cimetidine is a DRUG, fluoxetine is a DRUG, barbiturates is a GROUP, phenytoin is a DRUG, imipramine is a DRUG, tricyclic antidepressants is a GROUP, TCAs is a GROUP, TCA is a GROUP, TCA is a GROUP, quinidine is a DRUG, cimetidine is a DRUG, antidepressants is a GROUP, phenothiazines is a GROUP, Type 1C antiarrhythmics is a GROUP, propafenone is a DRUG, flecainide is a DRUG, selective serotonin reuptake inhibitors is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, sertraline is a DRUG, paroxetine is a DRUG, SSRI is a GROUP, TCA is a GROUP, SSRI is a GROUP, SSRIs is a GROUP, fluoxetine is a DRUG, tricyclic antidepressants is a GROUP, tricyclic antidepressant is a GROUP, tricyclic antidepressant is a GROUP, TCA is a GROUP, TCA is a GROUP

Imipramine_ddi_task1

Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please typing these entity words according to sentence: anticholinergic drugs, anticholinergic drugs, decongestants, anesthetics, sympathomimetic amine, epinephrine, norepinephrine, tricyclic antidepressants, imipramine hydrochloride, Imipramine hydrochloride, CNS depressant drugs, imipramine, cimetidine, fluoxetine, barbiturates, phenytoin, imipramine, tricyclic antidepressants, TCAs, TCA, TCA, quinidine, cimetidine, antidepressants, phenothiazines, Type 1C antiarrhythmics, propafenone, flecainide, selective serotonin reuptake inhibitors, SSRIs, fluoxetine, sertraline, paroxetine, SSRI, TCA, SSRI, SSRIs, fluoxetine, tricyclic antidepressants, tricyclic antidepressant, tricyclic antidepressant, TCA, TCA Options: GROUP, DRUG

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In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.

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"may", "become", "abruptly", "toxic", "when", "given", "one", "of", "these", "inhibiting", "drugs", "as", "concomitant", "therapy", ".", "The", "drugs", "that", "inhibit", "cytochrome", "P450", "2D6", "include", "some", "that", "are", "not", "metabolized", "by", "the", "enzyme", "(", "quinidine", ";", "cimetidine", ")", "and", "many", "that", "are", "substrates", "for", "P450", "2D6", "(", "many", "other", "antidepressants", ",", "phenothiazines", ",", "and", "the", "Type", "1C", "antiarrhythmics", "propafenone", "and", "flecainide", ")", ".", "While", "all", "the", "selective", "serotonin", "reuptake", "inhibitors", "(", "SSRIs", ")", ",", "e.", "g.", ",", "fluoxetine", ",", "sertraline", ",", "and", "paroxetine", ",", "inhibit", "P450", "2D6", ",", "they", "may", "vary", "in", "the", "extent", "of", "inhibition", ".", "The", "extent", "to", "which", "SSRI", "-", "TCA", "interactions", "may", "pose", "clinical", "problems", "will", "depend", "on", "the", "degree", "of", "inhibition", ",", "and", "the", "pharmacokinetics", "of", "the", "SSRI", "involved", ".", "Nevertheless", ",", "caution", "is", "indicated", "in", "the", "co", "-", "administration", "of", "TCA5", "with", "any", "of", "the", "SSRIs", "and", "also", "in", "switching", "from", "one", "class", "to", "the", "other", ".", "Of", "particular", "importance", ",", "sufficient", "time", "must", "elapse", "before", "initiating", "TCA", "treatment", "in", "a", "patient", "being", "withdrawn", "from", "fluoxetine", ",", "given", "the", "long", "half", "-", "life", "of", "the", "parent", "and", "active", "metabolite", "(", "at", "least", "5", "weeks", "may", "be", "necessary", ")", ".", "Concomitant", "use", "of", "tricyclic", "antidepressants", "with", "drugs", "that", "can", "inhibit", "cytochrome", "P450", "2D6", "may", "require", "lower", "doses", "than", "usually", "prescribed", "for", "either", "the", "tricyclic", "antidepressant", "or", "the", "other", "drug", ".", "Furthermore", ",", "whenever", "one", "of", "these", "other", "drugs", "is", "withdrawn", "from", "cotherapy", ",", "an", "increased", "dose", "of", "tricyclic", "antidepressant", "may", "be", "required", ".", "It", "is", "desirable", "to", "monitor", "TCA", "plasma", "levels", "whenever", "a", "TCA", "is", "going", "to", "be", "co", "-", "administered", "with", "another", "drug", "known", "to", "be", "an", "inhibitor", "of", "P450", "2D6", "." ]

[ "GROUP", "DRUG" ]

anticholinergic drugs, anticholinergic drugs, decongestants, anesthetics, sympathomimetic amine, epinephrine, norepinephrine, tricyclic antidepressants, imipramine hydrochloride, Imipramine hydrochloride, CNS depressant drugs, imipramine, cimetidine, fluoxetine, barbiturates, phenytoin, imipramine, tricyclic antidepressants, TCAs, TCA, TCA, quinidine, cimetidine, antidepressants, phenothiazines, Type 1C antiarrhythmics, propafenone, flecainide, selective serotonin reuptake inhibitors, SSRIs, fluoxetine, sertraline, paroxetine, SSRI, TCA, SSRI, SSRIs, fluoxetine, tricyclic antidepressants, tricyclic antidepressant, tricyclic antidepressant, TCA, TCA

Imipramine_ddi_task2

Sentence: In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6. Instructions: please extract entity words from the input sentence

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In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus). Close supervision and careful adjustment of dosage is required when this drug is administered concomitantly with anticholinergic drugs. Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure. Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. Drugs Metabolized by P450 2D6 The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called poor metabolizers); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA). In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e. g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCA5 with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.

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[ "GROUP", "DRUG" ]

breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean is a Plant, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean oil is a Plant, breast cancer is a Disease

12223422_task0

Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant

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Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.

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[ "Disease", "Plant" ]

breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean is a Plant, breast cancer is a Disease, breast cancer is a Disease, breast cancer is a Disease, soybean oil is a Plant, breast cancer is a Disease

12223422_task1

Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please typing these entity words according to sentence: breast cancer, breast cancer, breast cancer, breast cancer, soybean, breast cancer, breast cancer, breast cancer, soybean oil, breast cancer Options: Disease, Plant

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Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.

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[ "Disease", "Plant" ]

breast cancer, breast cancer, breast cancer, breast cancer, soybean, breast cancer, breast cancer, breast cancer, soybean oil, breast cancer

12223422_task2

Sentence: Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer. Instructions: please extract entity words from the input sentence

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Cumulative evidence suggests a possible interaction of cooking methods with diet in the pathogenesis of breast cancer. Studies, however, are few and inconsistent. We evaluated the association of animal food intake and degree of browning by deep-frying with breast cancer risk in a population-based case-control study conducted during 1996-1998 among Chinese women in Shanghai, a population with a traditionally low risk of breast cancer. Included in the study were 1459 cases and 1556 age-frequency-matched controls with response rates of 91.1 and 90.3%, respectively. A validated food frequency questionnaire was used to obtain information on usual intake of animal foods and cooking oils and usual cooking methods. Increasing intake of red meat and freshwater fish was related to a moderately elevated risk of breast cancer risk. Stratified analyses showed that the positive association with red meat intake was primarily restricted to those who used deep-frying cooking method, particularly among those who deep-fried foods to well-done (odds ratio, 1.92; 95% confidence interval, 1.30-2.83 for the highest versus the lowest quintile; P for trend, 0.002). On the other hand, high intake of nonhydrogenated soybean cooking oil was related to a reduced risk of breast cancer among women who never deep-fried animal foods (odds ratio, 0.48; 95% confidence interval, 0.28-0.82 for the highest versus the lowest quintile; P for trend, 0.02). The positive association of breast cancer risk with red meat intake, especially well-done red meat, was more pronounced among women with a high body mass index than those without this risk factor, and the test for multiplicative interaction was statistically significant. This study suggests that high intake of deep-fried, well-done red meat may be associated with an increased risk of breast cancer, and the positive association may be modified by body weight. This study also suggests that nonhydrogenated soybean oil, if not used in high-temperature cooking, may be associated with a reduced risk of breast cancer.

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[ "Disease", "Plant" ]

Radiotherapy is an umlsterm, standard is an umlsterm, therapy is an umlsterm, stage is an umlsterm, testicular seminoma is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm, stage is an umlsterm, disease is an umlsterm, stage is an umlsterm, Disease is an umlsterm, survival is an umlsterm, radiotherapy is an umlsterm, treatment is an umlsterm, choice is an umlsterm, neoplasia is an umlsterm, TIN is an umlsterm, testis is an umlsterm, TIN is an umlsterm, carcinoma is an umlsterm, testis is an umlsterm, Objectives is an umlsterm, clinical research is an umlsterm, radiotherapy is an umlsterm, malignancies is an umlsterm, aim is an umlsterm, treatment is an umlsterm, side effects is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm

DerUrologeA.00390126.eng.abstr_task0

Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .

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[ "umlsterm" ]

Radiotherapy is an umlsterm, standard is an umlsterm, therapy is an umlsterm, stage is an umlsterm, testicular seminoma is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm, stage is an umlsterm, disease is an umlsterm, stage is an umlsterm, Disease is an umlsterm, survival is an umlsterm, radiotherapy is an umlsterm, treatment is an umlsterm, choice is an umlsterm, neoplasia is an umlsterm, TIN is an umlsterm, testis is an umlsterm, TIN is an umlsterm, carcinoma is an umlsterm, testis is an umlsterm, Objectives is an umlsterm, clinical research is an umlsterm, radiotherapy is an umlsterm, malignancies is an umlsterm, aim is an umlsterm, treatment is an umlsterm, side effects is an umlsterm, irradiation is an umlsterm, tumour is an umlsterm, control is an umlsterm

DerUrologeA.00390126.eng.abstr_task1

Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please typing these entity words according to sentence: Radiotherapy, standard, therapy, stage, testicular seminoma, irradiation, tumour, control, stage, disease, stage, Disease, survival, radiotherapy, treatment, choice, neoplasia, TIN, testis, TIN, carcinoma, testis, Objectives, clinical research, radiotherapy, malignancies, aim, treatment, side effects, irradiation, tumour, control Options: umlsterm

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Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .

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[ "umlsterm" ]

Radiotherapy, standard, therapy, stage, testicular seminoma, irradiation, tumour, control, stage, disease, stage, Disease, survival, radiotherapy, treatment, choice, neoplasia, TIN, testis, TIN, carcinoma, testis, Objectives, clinical research, radiotherapy, malignancies, aim, treatment, side effects, irradiation, tumour, control

DerUrologeA.00390126.eng.abstr_task2

Sentence: Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates . Instructions: please extract entity words from the input sentence

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Radiotherapy unequivocally has to be regarded as standard therapy in stage I and IIA/B testicular seminoma . Using low dose abdominal irradiation tumour control rates of 95-98 % in stage I disease and 80-95 % in stage IIA/B can be achieved . Disease specific survival reaches 100 % . Likewise , radiotherapy is treatment of first choice in case of testicular intraepithelial neoplasia ( TIN ) in a solitary testis or in case of a double-sided TIN yielding safe eradication of the in-situ carcinoma of the testis . Objectives of further clinical research in radiotherapy of testicular malignancies aim at reduction of treatment intensity in order to minimize acute and late side effects of irradiation without compromising tumour control rates .

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[ "umlsterm" ]

Sun protection behaviors is a Intervention_Educational, skin cancers is a Participant_Condition, 2,324 is a Participant_Sample-size, sun protection behaviors is a Intervention_Educational, avoid the sun during midday is a Intervention_Educational, sunscreen is a Intervention_Other, sun protective behaviors is a Intervention_Educational

5780_task0

Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Intervention_Other, Participant_Condition, Participant_Sample-size

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Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Other", "Participant_Sample-size" ]

Sun protection behaviors is a Intervention_Educational, skin cancers is a Participant_Condition, 2,324 is a Participant_Sample-size, sun protection behaviors is a Intervention_Educational, avoid the sun during midday is a Intervention_Educational, sunscreen is a Intervention_Other, sun protective behaviors is a Intervention_Educational

5780_task1

Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please typing these entity words according to sentence: Sun protection behaviors, skin cancers, 2,324, sun protection behaviors, avoid the sun during midday, sunscreen, sun protective behaviors Options: Intervention_Educational, Intervention_Other, Participant_Condition, Participant_Sample-size

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Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Other", "Participant_Sample-size" ]

Sun protection behaviors, skin cancers, 2,324, sun protection behaviors, avoid the sun during midday, sunscreen, sun protective behaviors

5780_task2

Sentence: Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach . Instructions: please extract entity words from the input sentence

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Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England . Sun exposure is the most important avoidable cause of skin cancers . We report characteristics of a representative sample ( N = 2,324 ) of beachgoers in Southeastern New England during the summer of 1995 . This sample was not employing adequate sun protection behaviors ( 83 % did not often avoid the sun during midday and only 45 % often used sunscreen ) . Important demographic and skin cancer risk factor differences in sun protective behaviors and stages of change for sun protection were found , especially differences based on age , gender , and degree of sun sensitivity . Consistent with previous research , increased age , female gender , and greater sun sensitivity were each independently associated with more sun protective behaviors . These findings underscore the need for interventions targeting high-risk populations , such as those receiving high-intensity sun exposures at the beach .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Condition", "Intervention_Other", "Participant_Sample-size" ]

defibrillation is an umlsterm, emergency is an umlsterm, Germany is an umlsterm, use is an umlsterm, physicians is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, EMT is an umlsterm, emergency medical technician is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, life is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, survival is an umlsterm, survival is an umlsterm, emergency is an umlsterm, defibrillation is an umlsterm, program is an umlsterm, personnel is an umlsterm, basic life support is an umlsterm, defibrillation is an umlsterm, emergency is an umlsterm, physician is an umlsterm, paramedics is an umlsterm, training is an umlsterm, use is an umlsterm, personnel is an umlsterm, use is an umlsterm, defibrillation is an umlsterm, programs is an umlsterm, American Heart Association is an umlsterm, Resuscitation is an umlsterm, use is an umlsterm, devices is an umlsterm, personnel is an umlsterm, policemen is an umlsterm, personnel is an umlsterm, recommendation is an umlsterm

IntensiveMedizin.00370062.eng.abstr_task0

Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .

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[ "umlsterm" ]

defibrillation is an umlsterm, emergency is an umlsterm, Germany is an umlsterm, use is an umlsterm, physicians is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, EMT is an umlsterm, emergency medical technician is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, life is an umlsterm, defibrillation is an umlsterm, defibrillation is an umlsterm, survival is an umlsterm, survival is an umlsterm, emergency is an umlsterm, defibrillation is an umlsterm, program is an umlsterm, personnel is an umlsterm, basic life support is an umlsterm, defibrillation is an umlsterm, emergency is an umlsterm, physician is an umlsterm, paramedics is an umlsterm, training is an umlsterm, use is an umlsterm, personnel is an umlsterm, use is an umlsterm, defibrillation is an umlsterm, programs is an umlsterm, American Heart Association is an umlsterm, Resuscitation is an umlsterm, use is an umlsterm, devices is an umlsterm, personnel is an umlsterm, policemen is an umlsterm, personnel is an umlsterm, recommendation is an umlsterm

IntensiveMedizin.00370062.eng.abstr_task1

Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please typing these entity words according to sentence: defibrillation, emergency, Germany, use, physicians, defibrillation, defibrillation, EMT, emergency medical technician, defibrillation, defibrillation, defibrillation, life, defibrillation, defibrillation, survival, survival, emergency, defibrillation, program, personnel, basic life support, defibrillation, emergency, physician, paramedics, training, use, personnel, use, defibrillation, programs, American Heart Association, Resuscitation, use, devices, personnel, policemen, personnel, recommendation Options: umlsterm

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The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .

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[ "umlsterm" ]

defibrillation, emergency, Germany, use, physicians, defibrillation, defibrillation, EMT, emergency medical technician, defibrillation, defibrillation, defibrillation, life, defibrillation, defibrillation, survival, survival, emergency, defibrillation, program, personnel, basic life support, defibrillation, emergency, physician, paramedics, training, use, personnel, use, defibrillation, programs, American Heart Association, Resuscitation, use, devices, personnel, policemen, personnel, recommendation

IntensiveMedizin.00370062.eng.abstr_task2

Sentence: The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation . Instructions: please extract entity words from the input sentence

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The introduction of " early defibrillation " by emergency technicians ( nonphysicians ) in Germany led to a very emotional and controversial discussion , since the use of a defibrillator had previously been restricted to physicians . " Early defibrillation " by definition signifies immediate defibrillation by first-arriving nonphysician rescuers . The alternative term is EMT ( emergency medical technician ) defibrillation . The term early defibrillation is suggestive of very early defibrillation . Even if this is seldom achieved in real life , it points to the fact that this means the earliest possible defibrillation . " Early defibrillation " is closely related to the chain of survival concept . The clearly structured optimized chain of survival , a tiered emergency medical system , is a precondition for an effective early defibrillation program . In the tiered system of densely stationed , basically qualified rescue personnel , basic life support including defibrillation with semi-automatic defibrillators is started until the emergency physician ( in other countries paramedics ) arrives at the scene . Only a few hours of training are necessary to enable safe and effective use of semi-automatic defibrillators by basic rescue personnel . The use of semi-automatic defibrillators in early defibrillation programs is recommended by the American Heart Association and by the European Resuscitation Council . Even the use of these devices by minimally trained non-rescue personnel ( e.g. , policemen and other security personnel ) is a second-step recommendation .

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[ "umlsterm" ]

Blood pressure biofeedback treatment is a Intervention_Psychological, blood pressure is a Outcome_Physical, BP is a Outcome_Physical, biofeedback treatment ( BF ) is a Intervention_Psychological, Fifteen is a Participant_Sample-size, white - coat hypertensive is a Participant_Condition, 23 is a Participant_Sample-size, essential hypertensive is a Participant_Condition, visited the clinic is a Intervention_Physical, BPs of white - coat hypertensives and essential hypertensives is a Outcome_Physical, pulse is a Outcome_Physical, respiratory rates is a Outcome_Physical, elevation of diastolic BP due to mental stress testing is a Outcome_Physical

3063_task0

Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size

[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .

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[ "Outcome_Physical", "Intervention_Psychological", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Other" ]

Blood pressure biofeedback treatment is a Intervention_Psychological, blood pressure is a Outcome_Physical, BP is a Outcome_Physical, biofeedback treatment ( BF ) is a Intervention_Psychological, Fifteen is a Participant_Sample-size, white - coat hypertensive is a Participant_Condition, 23 is a Participant_Sample-size, essential hypertensive is a Participant_Condition, visited the clinic is a Intervention_Physical, BPs of white - coat hypertensives and essential hypertensives is a Outcome_Physical, pulse is a Outcome_Physical, respiratory rates is a Outcome_Physical, elevation of diastolic BP due to mental stress testing is a Outcome_Physical

3063_task1

Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please typing these entity words according to sentence: Blood pressure biofeedback treatment, blood pressure, BP, biofeedback treatment ( BF ), Fifteen, white - coat hypertensive, 23, essential hypertensive, visited the clinic, BPs of white - coat hypertensives and essential hypertensives, pulse, respiratory rates, elevation of diastolic BP due to mental stress testing Options: Intervention_Psychological, Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size

[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .

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[ "Outcome_Physical", "Intervention_Psychological", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Other" ]

Blood pressure biofeedback treatment, blood pressure, BP, biofeedback treatment ( BF ), Fifteen, white - coat hypertensive, 23, essential hypertensive, visited the clinic, BPs of white - coat hypertensives and essential hypertensives, pulse, respiratory rates, elevation of diastolic BP due to mental stress testing

3063_task2

Sentence: Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Blood pressure biofeedback treatment of white-coat hypertension . OBJECTIVE The objective of the study was to compare blood pressure ( BP ) biofeedback treatment ( BF ) effects between white-coat hypertension and essential hypertension . METHODS Fifteen white-coat hypertensive out-patients and 23 essential hypertensive out-patients were randomly assigned to groups A or B . Subjects in group A underwent BF once a week for a total of four sessions . Those in group B visited the clinic only to measure BP and later underwent the same BF . RESULTS In group A , BPs of white-coat hypertensives and essential hypertensives were significantly reduced by 22/11 and 14/8 mmHg , respectively . In group B , they were unchanged during the same period but later suppressed by BF . Under BF , pulse and respiratory rates were significantly higher , and elevation of diastolic BP due to mental stress testing was better suppressed in white-coat hypertensives than in essential hypertensives . CONCLUSION This treatment was effective in both types of hypertension , and pressor response to stress seems to be important in the differentiated BF effect .

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[ "Outcome_Physical", "Intervention_Psychological", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Other" ]

Prophylactic cranial irradiation is a Intervention_Physical, patients with small - cell lung cancer in complete remission is a Participant_Condition, overall survival . is a Outcome_Mortality, patients in complete remission is a Participant_Condition, prophylactic cranial irradiation is a Intervention_Physical, brain metastasis , overall survival is a Outcome_Mortality, late - occurring toxic effects is a Outcome_Adverse-effects, 300 is a Participant_Sample-size, patients who had small - cell lung cancer that was in complete remission is a Participant_Condition, no prophylactic cranial irradiation ( control group ) is a Intervention_Physical, relapse is a Outcome_Mental, Two hundred ninety - four patients is a Participant_Sample-size, 2-year cumulative rate of brain metastasis is a Outcome_Mental, total 2-year rate of brain metastasis is a Outcome_Physical, 2-year overall survival rate is a Outcome_Mortality, neuropsychological function or abnormalities is a Outcome_Physical, patients who are in complete remission is a Participant_Condition

81986_task0

Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Adverse-effects, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]

Prophylactic cranial irradiation is a Intervention_Physical, patients with small - cell lung cancer in complete remission is a Participant_Condition, overall survival . is a Outcome_Mortality, patients in complete remission is a Participant_Condition, prophylactic cranial irradiation is a Intervention_Physical, brain metastasis , overall survival is a Outcome_Mortality, late - occurring toxic effects is a Outcome_Adverse-effects, 300 is a Participant_Sample-size, patients who had small - cell lung cancer that was in complete remission is a Participant_Condition, no prophylactic cranial irradiation ( control group ) is a Intervention_Physical, relapse is a Outcome_Mental, Two hundred ninety - four patients is a Participant_Sample-size, 2-year cumulative rate of brain metastasis is a Outcome_Mental, total 2-year rate of brain metastasis is a Outcome_Physical, 2-year overall survival rate is a Outcome_Mortality, neuropsychological function or abnormalities is a Outcome_Physical, patients who are in complete remission is a Participant_Condition

81986_task1

Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . Instructions: please typing these entity words according to sentence: Prophylactic cranial irradiation, patients with small - cell lung cancer in complete remission, overall survival ., patients in complete remission, prophylactic cranial irradiation, brain metastasis , overall survival, late - occurring toxic effects, 300, patients who had small - cell lung cancer that was in complete remission, no prophylactic cranial irradiation ( control group ), relapse, Two hundred ninety - four patients, 2-year cumulative rate of brain metastasis, total 2-year rate of brain metastasis, 2-year overall survival rate, neuropsychological function or abnormalities, patients who are in complete remission Options: Outcome_Adverse-effects, Intervention_Physical, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]

Prophylactic cranial irradiation, patients with small - cell lung cancer in complete remission, overall survival ., patients in complete remission, prophylactic cranial irradiation, brain metastasis , overall survival, late - occurring toxic effects, 300, patients who had small - cell lung cancer that was in complete remission, no prophylactic cranial irradiation ( control group ), relapse, Two hundred ninety - four patients, 2-year cumulative rate of brain metastasis, total 2-year rate of brain metastasis, 2-year overall survival rate, neuropsychological function or abnormalities, patients who are in complete remission

81986_task2

Sentence: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended . Instructions: please extract entity words from the input sentence

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Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission . BACKGROUND Prophylactic cranial irradiation in patients with small-cell lung cancer decreases the overall rate of brain metastases without an effect on overall survival . It has been suggested that this treatment may increase neuropsychological syndromes and brain abnormalities indicated by computed tomography scans . However , other retrospective data suggested a beneficial effect on overall survival for patients in complete remission . PURPOSE Our purpose was to evaluate the effects of prophylactic cranial irradiation on brain metastasis , overall survival , and late-occurring toxic effects in patients with small-cell lung cancer in complete remission . METHODS We conducted a prospective study of 300 patients who had small-cell lung cancer that was in complete remission . The patients were randomly assigned to receive either prophylactic cranial irradiation delivering 24 Gy in eight fractions during 12 days ( treatment group ) or no prophylactic cranial irradiation ( control group ) . A neuropsychological examination and a computed tomography scan of the brain were performed at the time of random assignment and repeatedly assessed at 6 , 18 , 30 , and 48 months . Patterns of failure were analyzed according to total event rates and also according to an isolated first site of relapse , using a competing-risk approach . RESULTS Two hundred ninety-four patients who did not have brain metastases at the time of random assignment were analyzed . The 2-year cumulative rate of brain metastasis as an isolated first site of relapse was 45 % in the control group and 19 % in the treatment group ( P < 10 ( -6 ) ) . The total 2-year rate of brain metastasis was 67 % and 40 % , respectively ( relative risk = 0.35 ; P < 10 ( -13 ) ) . The 2-year overall survival rate was 21.5 % in the control group and 29 % in the treatment group ( relative risk = 0.83 ; P = .14 ) . There were no significant differences between the two groups in terms of neuropsychological function or abnormalities indicated by computed tomography brain scans . CONCLUSIONS Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications . A possible beneficial effect on overall survival should be tested with a higher statistical power . IMPLICATIONS The results of the trial favor , at present , the indication of prophylactic cranial irradiation for patients who are in complete remission . A longer follow-up and confirmatory trials are needed to fully assess late-occurring toxic effects . The possible effect on overall survival needs to be evaluated with a larger number of patients in complete remission , and a meta-analysis of similar trials is recommended .

[ "Prophylactic", "cranial", "irradiation", "for", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "BACKGROUND", "Prophylactic", "cranial", "irradiation", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "decreases", "the", "overall", "rate", "of", "brain", "metastases", "without", "an", "effect", "on", "overall", "survival", ".", "It", "has", "been", "suggested", "that", "this", "treatment", "may", "increase", "neuropsychological", "syndromes", "and", "brain", "abnormalities", "indicated", "by", "computed", "tomography", "scans", ".", "However", ",", "other", "retrospective", "data", "suggested", "a", "beneficial", "effect", "on", "overall", "survival", "for", "patients", "in", "complete", "remission", ".", "PURPOSE", "Our", "purpose", "was", "to", "evaluate", "the", "effects", "of", "prophylactic", "cranial", "irradiation", "on", "brain", "metastasis", ",", "overall", "survival", ",", "and", "late", "-", "occurring", "toxic", "effects", "in", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", ".", "METHODS", "We", "conducted", "a", "prospective", "study", "of", "300", "patients", "who", "had", "small", "-", "cell", "lung", "cancer", "that", "was", "in", "complete", "remission", ".", "The", "patients", "were", "randomly", "assigned", "to", "receive", "either", "prophylactic", "cranial", "irradiation", "delivering", "24", "Gy", "in", "eight", "fractions", "during", "12", "days", "(", "treatment", "group", ")", "or", "no", "prophylactic", "cranial", "irradiation", "(", "control", "group", ")", ".", "A", "neuropsychological", "examination", "and", "a", "computed", "tomography", "scan", "of", "the", "brain", "were", "performed", "at", "the", "time", "of", "random", "assignment", "and", "repeatedly", "assessed", "at", "6", ",", "18", ",", "30", ",", "and", "48", "months", ".", "Patterns", "of", "failure", "were", "analyzed", "according", "to", "total", "event", "rates", "and", "also", "according", "to", "an", "isolated", "first", "site", "of", "relapse", ",", "using", "a", "competing", "-", "risk", "approach", ".", "RESULTS", "Two", "hundred", "ninety", "-", "four", "patients", "who", "did", "not", "have", "brain", "metastases", "at", "the", "time", "of", "random", "assignment", "were", "analyzed", ".", "The", "2-year", "cumulative", "rate", "of", "brain", "metastasis", "as", "an", "isolated", "first", "site", "of", "relapse", "was", "45", "%", "in", "the", "control", "group", "and", "19", "%", "in", "the", "treatment", "group", "(", "P", "<", "10", "(", "-6", ")", ")", ".", "The", "total", "2-year", "rate", "of", "brain", "metastasis", "was", "67", "%", "and", "40", "%", ",", "respectively", "(", "relative", "risk", "=", "0.35", ";", "P", "<", "10", "(", "-13", ")", ")", ".", "The", "2-year", "overall", "survival", "rate", "was", "21.5", "%", "in", "the", "control", "group", "and", "29", "%", "in", "the", "treatment", "group", "(", "relative", "risk", "=", "0.83", ";", "P", "=", ".14", ")", ".", "There", "were", "no", "significant", "differences", "between", "the", "two", "groups", "in", "terms", "of", "neuropsychological", "function", "or", "abnormalities", "indicated", "by", "computed", "tomography", "brain", "scans", ".", "CONCLUSIONS", "Prophylactic", "cranial", "irradiation", "given", "to", "patients", "with", "small", "-", "cell", "lung", "cancer", "in", "complete", "remission", "decreases", "the", "risk", "of", "brain", "metastasis", "threefold", "without", "a", "significant", "increase", "in", "complications", ".", "A", "possible", "beneficial", "effect", "on", "overall", "survival", "should", "be", "tested", "with", "a", "higher", "statistical", "power", ".", "IMPLICATIONS", "The", "results", "of", "the", "trial", "favor", ",", "at", "present", ",", "the", "indication", "of", "prophylactic", "cranial", "irradiation", "for", "patients", "who", "are", "in", "complete", "remission", ".", "A", "longer", "follow", "-", "up", "and", "confirmatory", "trials", "are", "needed", "to", "fully", "assess", "late", "-", "occurring", "toxic", "effects", ".", "The", "possible", "effect", "on", "overall", "survival", "needs", "to", "be", "evaluated", "with", "a", "larger", "number", "of", "patients", "in", "complete", "remission", ",", "and", "a", "meta", "-", "analysis", "of", "similar", "trials", "is", "recommended", "." ]

[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Outcome_Mental", "Outcome_Mortality", "Participant_Sample-size", "Outcome_Adverse-effects" ]

hypoglossal nerve palsy is an umlsterm, nasal septum is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, distance is an umlsterm, hypoglossal nerve is an umlsterm, surgery is an umlsterm, literature is an umlsterm, palsy is an umlsterm, endotracheal intubation is an umlsterm, use is an umlsterm, laryngeal mask airway is an umlsterm, bronchoscopy is an umlsterm, laryngoscopy is an umlsterm

DerAnaesthesist.70460034.eng.abstr_task0

Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]

Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .

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[ "umlsterm" ]

hypoglossal nerve palsy is an umlsterm, nasal septum is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, distance is an umlsterm, hypoglossal nerve is an umlsterm, surgery is an umlsterm, literature is an umlsterm, palsy is an umlsterm, endotracheal intubation is an umlsterm, use is an umlsterm, laryngeal mask airway is an umlsterm, bronchoscopy is an umlsterm, laryngoscopy is an umlsterm

DerAnaesthesist.70460034.eng.abstr_task1

Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please typing these entity words according to sentence: hypoglossal nerve palsy, nasal septum, surgery, intubation, distance, hypoglossal nerve, surgery, literature, palsy, endotracheal intubation, use, laryngeal mask airway, bronchoscopy, laryngoscopy Options: umlsterm

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Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .

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[ "umlsterm" ]

hypoglossal nerve palsy, nasal septum, surgery, intubation, distance, hypoglossal nerve, surgery, literature, palsy, endotracheal intubation, use, laryngeal mask airway, bronchoscopy, laryngoscopy

DerAnaesthesist.70460034.eng.abstr_task2

Sentence: Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]

Background : We report a case of irreversible unilateral hypoglossal nerve palsy in connection with nasal septum surgery in intubation anaesthesia . On account of the spatial distance , there is no danger of injuring the hypoglossal nerve during nasal surgery . However , in the otorhinolaryngological and anaesthesiological literature , some cases of hypoglossal palsy following endotracheal intubation , use of the laryngeal mask airway , bronchoscopy and laryngoscopy are reported .

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[ "umlsterm" ]

contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) is a Intervention_Physical, hydrogel Acuvue 2 ( etafilcon A ) contact lenses is a Intervention_Physical, extended wear ( EW ) is a Participant_Condition, 55 is a Participant_Sample-size, 53 is a Participant_Sample-size, Lipid uptake is a Outcome_Physical, total lipid is a Outcome_Physical, cholesterol esters is a Outcome_Physical, triglycerides / phospholipids is a Outcome_Physical, fatty acid is a Outcome_Physical, ratio of the extracted lipids is a Outcome_Physical, fatty acids / di- and monoglycerides is a Outcome_Physical, Total lipid uptake is a Outcome_Physical, uptake of lipids is a Outcome_Physical

67094_task0

Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size

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Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) is a Intervention_Physical, hydrogel Acuvue 2 ( etafilcon A ) contact lenses is a Intervention_Physical, extended wear ( EW ) is a Participant_Condition, 55 is a Participant_Sample-size, 53 is a Participant_Sample-size, Lipid uptake is a Outcome_Physical, total lipid is a Outcome_Physical, cholesterol esters is a Outcome_Physical, triglycerides / phospholipids is a Outcome_Physical, fatty acid is a Outcome_Physical, ratio of the extracted lipids is a Outcome_Physical, fatty acids / di- and monoglycerides is a Outcome_Physical, Total lipid uptake is a Outcome_Physical, uptake of lipids is a Outcome_Physical

67094_task1

Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . Instructions: please typing these entity words according to sentence: contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ), hydrogel Acuvue 2 ( etafilcon A ) contact lenses, extended wear ( EW ), 55, 53, Lipid uptake, total lipid, cholesterol esters, triglycerides / phospholipids, fatty acid, ratio of the extracted lipids, fatty acids / di- and monoglycerides, Total lipid uptake, uptake of lipids Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size

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Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ), hydrogel Acuvue 2 ( etafilcon A ) contact lenses, extended wear ( EW ), 55, 53, Lipid uptake, total lipid, cholesterol esters, triglycerides / phospholipids, fatty acid, ratio of the extracted lipids, fatty acids / di- and monoglycerides, Total lipid uptake, uptake of lipids

67094_task2

Sentence: Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect . Instructions: please extract entity words from the input sentence

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Contact lens lipid spoliation of hydrogel and silicone hydrogel lenses . PURPOSE The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue 2 ( etafilcon A ) contact lenses worn for 10 hours single use ( DD ) and 7 days of extended wear ( EW ) . METHODS Two similar study populations ( DD , n = 55 ; EW , n = 53 ) , were enrolled at four study sites . In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed . Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) . RESULTS Lipid uptake was different for the two materials : total lipid ( p < 0.007 ) , cholesterol esters ( p < 0.001 ) , cholesterol ( p < 0.001 EW only ) , and triglycerides/phospholipids ( p < 0.001 ) were higher for balafilcon A , whereas fatty acid ( p < 0.0025 EW only ) was higher for etafilcon A . The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < 0.001 ) and cholesterol ( p < 0.001 EW only ) for balafilcon A and higher percentages of fatty acids/di- and monoglycerides ( p < 0.014 ) for etafilcon A . CONCLUSIONS Total lipid uptake was highly material dependent . Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only 10 hours of DD . Total lipid uptake was greater after 7 days of EW compared with 10 hours of DD . Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity . Whereas greater differentiation between materials was possible after 7 days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

infection is an umlsterm, infection is an umlsterm, signs is an umlsterm, cultures is an umlsterm, inflammation is an umlsterm, Scintigraphy is an umlsterm, white blood cells is an umlsterm, WBC is an umlsterm, diagnosis is an umlsterm, sepsis is an umlsterm, musculoskeletal system is an umlsterm, patients is an umlsterm, infection is an umlsterm, prospectively studied is an umlsterm, Infection is an umlsterm, hip joint prosthesis is an umlsterm, knee joint prosthesis is an umlsterm, shoulder is an umlsterm, joint prosthesis is an umlsterm, All is an umlsterm, WBC is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, infections is an umlsterm, culture is an umlsterm, histologic is an umlsterm, culture is an umlsterm, histologic is an umlsterm, sensitivity is an umlsterm, imaging is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, imaging is an umlsterm, diagnosis is an umlsterm, infection is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm

DerChirurg.70681181.eng.abstr_task0

Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .

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[ "umlsterm" ]

infection is an umlsterm, infection is an umlsterm, signs is an umlsterm, cultures is an umlsterm, inflammation is an umlsterm, Scintigraphy is an umlsterm, white blood cells is an umlsterm, WBC is an umlsterm, diagnosis is an umlsterm, sepsis is an umlsterm, musculoskeletal system is an umlsterm, patients is an umlsterm, infection is an umlsterm, prospectively studied is an umlsterm, Infection is an umlsterm, hip joint prosthesis is an umlsterm, knee joint prosthesis is an umlsterm, shoulder is an umlsterm, joint prosthesis is an umlsterm, All is an umlsterm, WBC is an umlsterm, surgery is an umlsterm, surgery is an umlsterm, infections is an umlsterm, culture is an umlsterm, histologic is an umlsterm, culture is an umlsterm, histologic is an umlsterm, sensitivity is an umlsterm, imaging is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, WBC is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, imaging is an umlsterm, diagnosis is an umlsterm, infection is an umlsterm, imaging is an umlsterm, standard is an umlsterm, diagnostic is an umlsterm, methods is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm

DerChirurg.70681181.eng.abstr_task1

Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please typing these entity words according to sentence: infection, infection, signs, cultures, inflammation, Scintigraphy, white blood cells, WBC, diagnosis, sepsis, musculoskeletal system, patients, infection, prospectively studied, Infection, hip joint prosthesis, knee joint prosthesis, shoulder, joint prosthesis, All, WBC, surgery, surgery, infections, culture, histologic, culture, histologic, sensitivity, imaging, patients, rheumatoid arthritis, WBC, imaging, standard, diagnostic, methods, patients, WBC, imaging, standard, diagnostic, methods, imaging, diagnosis, infection, imaging, standard, diagnostic, methods, patients, rheumatoid arthritis Options: umlsterm

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When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .

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[ "umlsterm" ]

infection, infection, signs, cultures, inflammation, Scintigraphy, white blood cells, WBC, diagnosis, sepsis, musculoskeletal system, patients, infection, prospectively studied, Infection, hip joint prosthesis, knee joint prosthesis, shoulder, joint prosthesis, All, WBC, surgery, surgery, infections, culture, histologic, culture, histologic, sensitivity, imaging, patients, rheumatoid arthritis, WBC, imaging, standard, diagnostic, methods, patients, WBC, imaging, standard, diagnostic, methods, imaging, diagnosis, infection, imaging, standard, diagnostic, methods, patients, rheumatoid arthritis

DerChirurg.70681181.eng.abstr_task2

Sentence: When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis . Instructions: please extract entity words from the input sentence

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When infection of implants is suspected , optimal management requires accurate confirmation or exclusion of infection . However , in spite of demonstrative clinical signs cultures of smears or chemical parameters of inflammation frequently are ambiguous . Scintigraphy with indium-labeled white blood cells ( WBC ) has been reported to be sensitive and specific in the diagnosis of low-grade sepsis of the musculoskeletal system . Twenty-eight patients with possible infection were prospectively studied . Infection was suspected in 19 cases with total hip joint prosthesis , 14 cases with knee joint prosthesis and 1 case with shoulder joint prosthesis . All of them underwent scanning with indium-111-labeled WBC and subsequently underwent surgery . At surgery infections were determined by means of culture or histologic results . When correlated with culture and histologic results sensitivity of 111-indium-WBC imaging was 89 % , with a specifity of 67 % and a predictive accuracy of 77 % . In patients with rheumatoid arthritis , however , predictive accuracy of 111-indium-labeled WBC imaging was higher than with standard diagnostic methods . The difference was statistically significant ( P 0.05 , 2-test ) . In the patients examined as a whole , predictive accuracy of 111-indium-labeled WBC imaging does not differ from that of standard diagnostic methods . That is why expensive and time-consuming 111-indium-WBC imaging is not justified generally in diagnosis of infection of implants . 111-Indium-WBC imaging is well suited to supplement standard diagnostic methods in patients with rheumatoid arthritis .

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[ "umlsterm" ]

over 40 years is a Value, Medical examination is a Procedure, prior to participation in research is a Temporal, without is a Negation, history is a Observation, inner ear disease is a Condition

NCT02529475_inc_task0

Sentence: Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years) Informed consent signed Medical examination performed prior to participation in research Patients without history of inner ear disease Recipient of a French social security scheme Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Observation, Procedure, Negation

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Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years) Informed consent signed Medical examination performed prior to participation in research Patients without history of inner ear disease Recipient of a French social security scheme

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