bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
Glucose is a CHEMICAL	23585333_task1	Sentence: Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering. Instructions: please typing these entity words according to sentence: Glucose Options: CHEMICAL	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering.	[ "Tandem", "Assays", "of", "Protein", "and", "Glucose", "with", "Functionalized", "Core", "/", "Shell", "Particles", "Based", "on", "Magnetic", "Separation", "and", "Surface", "-", "Enhanced", "Raman", "Scattering", "." ]	[ "CHEMICAL" ]
Glucose	23585333_task2	Sentence: Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering.	[ "Tandem", "Assays", "of", "Protein", "and", "Glucose", "with", "Functionalized", "Core", "/", "Shell", "Particles", "Based", "on", "Magnetic", "Separation", "and", "Surface", "-", "Enhanced", "Raman", "Scattering", "." ]	[ "CHEMICAL" ]
clonidine is an umlsterm, afferent neurons is an umlsterm, horn is an umlsterm, spinal cord is an umlsterm, analgesia is an umlsterm, inhibition is an umlsterm, analgesic is an umlsterm, time is an umlsterm, pain is an umlsterm, clonidine is an umlsterm, analgesia is an umlsterm, heart rate is an umlsterm, cardiac output is an umlsterm, blood pressure is an umlsterm, baseline is an umlsterm, haemodynamic is an umlsterm, side effects is an umlsterm, supervision is an umlsterm, use is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, analgesic is an umlsterm, opioid is an umlsterm, local anaesthetics is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, clonidine is an umlsterm, opioid is an umlsterm, local anaesthetic is an umlsterm, interactions is an umlsterm, drugs is an umlsterm	DerSchmerz.60100057.eng.abstr_task0	Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .	[ "Spinal", "clonidine", "interacts", "with", "pre-", "and", "postsynaptic", "2-adrenoceptors", "on", "afferent", "neurons", "in", "the", "superficial", "dorsal", "horn", "of", "the", "spinal", "cord", ":", "it", "causes", "analgesia", "by", "inhibition", "of", "the", "synaptic", "and", "electrotonic", "neurotransmission", "of", "nociceptive", "impulses", ".", "Epidural", "doses", "higher", "than", "4", "µg", "/", "kg", "have", "an", "analgesic", "onset", "time", "of", "less", "than", "30", "min", ",", "reduce", "pain", "by", "more", "than", "70", "%", ";", "these", "effects", "last", "for", "4", "-", "5", "h", ".", "Epidural", "clonidine", "analgesia", "is", "accompanied", "by", "a", "reduction", "in", "heart", "rate", ",", "cardiac", "output", "and", "blood", "pressure", "of", "approximately", "20", "%", "compared", "with", "baseline", ".", "The", "haemodynamic", "side", "effects", "mean", "close", "supervision", "is", "needed", "during", "the", "first", "hour", "after", "epidural", "application", "and", "limit", "the", "use", "of", "epidural", "clonidine", "to", "patients", "who", "are", "refractory", "to", "the", "analgesic", "effects", "of", "epidural", "opioid", "or", "local", "anaesthetics", ".", "In", "these", "patients", "excellent", "results", "can", "be", "achieved", "either", "with", "clonidine", "alone", "or", "with", "a", "combination", "of", "clonidine", "and", "an", "opioid", "or", "a", "local", "anaesthetic", "to", "exploit", "the", "additive", "or", "supra", "-", "additive", "interactions", "of", "these", "drugs", "." ]	[ "umlsterm" ]
clonidine is an umlsterm, afferent neurons is an umlsterm, horn is an umlsterm, spinal cord is an umlsterm, analgesia is an umlsterm, inhibition is an umlsterm, analgesic is an umlsterm, time is an umlsterm, pain is an umlsterm, clonidine is an umlsterm, analgesia is an umlsterm, heart rate is an umlsterm, cardiac output is an umlsterm, blood pressure is an umlsterm, baseline is an umlsterm, haemodynamic is an umlsterm, side effects is an umlsterm, supervision is an umlsterm, use is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, analgesic is an umlsterm, opioid is an umlsterm, local anaesthetics is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, clonidine is an umlsterm, opioid is an umlsterm, local anaesthetic is an umlsterm, interactions is an umlsterm, drugs is an umlsterm	DerSchmerz.60100057.eng.abstr_task1	Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please typing these entity words according to sentence: clonidine, afferent neurons, horn, spinal cord, analgesia, inhibition, analgesic, time, pain, clonidine, analgesia, heart rate, cardiac output, blood pressure, baseline, haemodynamic, side effects, supervision, use, clonidine, patients, analgesic, opioid, local anaesthetics, patients, clonidine, clonidine, opioid, local anaesthetic, interactions, drugs Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .	[ "Spinal", "clonidine", "interacts", "with", "pre-", "and", "postsynaptic", "2-adrenoceptors", "on", "afferent", "neurons", "in", "the", "superficial", "dorsal", "horn", "of", "the", "spinal", "cord", ":", "it", "causes", "analgesia", "by", "inhibition", "of", "the", "synaptic", "and", "electrotonic", "neurotransmission", "of", "nociceptive", "impulses", ".", "Epidural", "doses", "higher", "than", "4", "µg", "/", "kg", "have", "an", "analgesic", "onset", "time", "of", "less", "than", "30", "min", ",", "reduce", "pain", "by", "more", "than", "70", "%", ";", "these", "effects", "last", "for", "4", "-", "5", "h", ".", "Epidural", "clonidine", "analgesia", "is", "accompanied", "by", "a", "reduction", "in", "heart", "rate", ",", "cardiac", "output", "and", "blood", "pressure", "of", "approximately", "20", "%", "compared", "with", "baseline", ".", "The", "haemodynamic", "side", "effects", "mean", "close", "supervision", "is", "needed", "during", "the", "first", "hour", "after", "epidural", "application", "and", "limit", "the", "use", "of", "epidural", "clonidine", "to", "patients", "who", "are", "refractory", "to", "the", "analgesic", "effects", "of", "epidural", "opioid", "or", "local", "anaesthetics", ".", "In", "these", "patients", "excellent", "results", "can", "be", "achieved", "either", "with", "clonidine", "alone", "or", "with", "a", "combination", "of", "clonidine", "and", "an", "opioid", "or", "a", "local", "anaesthetic", "to", "exploit", "the", "additive", "or", "supra", "-", "additive", "interactions", "of", "these", "drugs", "." ]	[ "umlsterm" ]
clonidine, afferent neurons, horn, spinal cord, analgesia, inhibition, analgesic, time, pain, clonidine, analgesia, heart rate, cardiac output, blood pressure, baseline, haemodynamic, side effects, supervision, use, clonidine, patients, analgesic, opioid, local anaesthetics, patients, clonidine, clonidine, opioid, local anaesthetic, interactions, drugs	DerSchmerz.60100057.eng.abstr_task2	Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .	[ "Spinal", "clonidine", "interacts", "with", "pre-", "and", "postsynaptic", "2-adrenoceptors", "on", "afferent", "neurons", "in", "the", "superficial", "dorsal", "horn", "of", "the", "spinal", "cord", ":", "it", "causes", "analgesia", "by", "inhibition", "of", "the", "synaptic", "and", "electrotonic", "neurotransmission", "of", "nociceptive", "impulses", ".", "Epidural", "doses", "higher", "than", "4", "µg", "/", "kg", "have", "an", "analgesic", "onset", "time", "of", "less", "than", "30", "min", ",", "reduce", "pain", "by", "more", "than", "70", "%", ";", "these", "effects", "last", "for", "4", "-", "5", "h", ".", "Epidural", "clonidine", "analgesia", "is", "accompanied", "by", "a", "reduction", "in", "heart", "rate", ",", "cardiac", "output", "and", "blood", "pressure", "of", "approximately", "20", "%", "compared", "with", "baseline", ".", "The", "haemodynamic", "side", "effects", "mean", "close", "supervision", "is", "needed", "during", "the", "first", "hour", "after", "epidural", "application", "and", "limit", "the", "use", "of", "epidural", "clonidine", "to", "patients", "who", "are", "refractory", "to", "the", "analgesic", "effects", "of", "epidural", "opioid", "or", "local", "anaesthetics", ".", "In", "these", "patients", "excellent", "results", "can", "be", "achieved", "either", "with", "clonidine", "alone", "or", "with", "a", "combination", "of", "clonidine", "and", "an", "opioid", "or", "a", "local", "anaesthetic", "to", "exploit", "the", "additive", "or", "supra", "-", "additive", "interactions", "of", "these", "drugs", "." ]	[ "umlsterm" ]
Tetrahydrobiopterin is a Intervention_Pharmacological, placebo - controlled is a Intervention_Control, Treatment - induced effects is a Outcome_Physical, Childhood Autism Rating Scale is a Outcome_Mental, total scores of Childhood Autism Rating Scale is a Outcome_Mental, social interaction , communication , and stereotyped behaviors is a Outcome_Mental, social interaction score is a Outcome_Mental, response of the social interaction score and IQ . is a Outcome_Mental	23558_task0	Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mental	[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .	[ "Tetrahydrobiopterin", "in", "the", "treatment", "of", "children", "with", "autistic", "disorder", ":", "a", "double", "-", "blind", "placebo", "-", "controlled", "crossover", "study", ".", "Twelve", "children", ",", "all", "boys", ",", "aged", "4", "to", "7", "years", ",", "with", "a", "diagnosis", "of", "autistic", "disorder", "and", "low", "concentrations", "of", "spinal", "6R", "-", "l", "-", "erythro-5,6,7,8-tetrahydrobiopterin", "(", "tetrahydrobiopterin", ")", "were", "selected", "to", "participate", "in", "a", "double", "-", "blind", ",", "randomized", ",", "placebo", "-", "controlled", ",", "crossover", "study", ".", "The", "children", "received", "a", "daily", "dose", "of", "3", "mg", "tetrahydrobiopterin", "per", "kilogram", "during", "6", "months", "alternating", "with", "placebo", ".", "Treatment", "-", "induced", "effects", "were", "assessed", "with", "the", "Childhood", "Autism", "Rating", "Scale", "every", "third", "month", ".", "The", "results", "showed", "small", "nonsignificant", "changes", "in", "the", "total", "scores", "of", "Childhood", "Autism", "Rating", "Scale", "after", "3-", "and", "6-month", "treatment", ".", "Post", "hoc", "analysis", "looking", "at", "the", "3", "core", "symptoms", "of", "autism", ",", "that", "is", ",", "social", "interaction", ",", "communication", ",", "and", "stereotyped", "behaviors", ",", "revealed", "a", "significant", "improvement", "of", "the", "social", "interaction", "score", "after", "6", "months", "of", "active", "treatment", ".", "In", "addition", ",", "a", "high", "positive", "correlation", "was", "found", "between", "response", "of", "the", "social", "interaction", "score", "and", "IQ", ".", "The", "results", "indicate", "a", "possible", "effect", "of", "tetrahydrobiopterin", "treatment", "." ]	[ "Outcome_Mental", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]
Tetrahydrobiopterin is a Intervention_Pharmacological, placebo - controlled is a Intervention_Control, Treatment - induced effects is a Outcome_Physical, Childhood Autism Rating Scale is a Outcome_Mental, total scores of Childhood Autism Rating Scale is a Outcome_Mental, social interaction , communication , and stereotyped behaviors is a Outcome_Mental, social interaction score is a Outcome_Mental, response of the social interaction score and IQ . is a Outcome_Mental	23558_task1	Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please typing these entity words according to sentence: Tetrahydrobiopterin, placebo - controlled, Treatment - induced effects, Childhood Autism Rating Scale, total scores of Childhood Autism Rating Scale, social interaction , communication , and stereotyped behaviors, social interaction score, response of the social interaction score and IQ . Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mental	[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .	[ "Tetrahydrobiopterin", "in", "the", "treatment", "of", "children", "with", "autistic", "disorder", ":", "a", "double", "-", "blind", "placebo", "-", "controlled", "crossover", "study", ".", "Twelve", "children", ",", "all", "boys", ",", "aged", "4", "to", "7", "years", ",", "with", "a", "diagnosis", "of", "autistic", "disorder", "and", "low", "concentrations", "of", "spinal", "6R", "-", "l", "-", "erythro-5,6,7,8-tetrahydrobiopterin", "(", "tetrahydrobiopterin", ")", "were", "selected", "to", "participate", "in", "a", "double", "-", "blind", ",", "randomized", ",", "placebo", "-", "controlled", ",", "crossover", "study", ".", "The", "children", "received", "a", "daily", "dose", "of", "3", "mg", "tetrahydrobiopterin", "per", "kilogram", "during", "6", "months", "alternating", "with", "placebo", ".", "Treatment", "-", "induced", "effects", "were", "assessed", "with", "the", "Childhood", "Autism", "Rating", "Scale", "every", "third", "month", ".", "The", "results", "showed", "small", "nonsignificant", "changes", "in", "the", "total", "scores", "of", "Childhood", "Autism", "Rating", "Scale", "after", "3-", "and", "6-month", "treatment", ".", "Post", "hoc", "analysis", "looking", "at", "the", "3", "core", "symptoms", "of", "autism", ",", "that", "is", ",", "social", "interaction", ",", "communication", ",", "and", "stereotyped", "behaviors", ",", "revealed", "a", "significant", "improvement", "of", "the", "social", "interaction", "score", "after", "6", "months", "of", "active", "treatment", ".", "In", "addition", ",", "a", "high", "positive", "correlation", "was", "found", "between", "response", "of", "the", "social", "interaction", "score", "and", "IQ", ".", "The", "results", "indicate", "a", "possible", "effect", "of", "tetrahydrobiopterin", "treatment", "." ]	[ "Outcome_Mental", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]
Tetrahydrobiopterin, placebo - controlled, Treatment - induced effects, Childhood Autism Rating Scale, total scores of Childhood Autism Rating Scale, social interaction , communication , and stereotyped behaviors, social interaction score, response of the social interaction score and IQ .	23558_task2	Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .	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guamerin - derived peptide is a Entity, guamerin - derived synthetic peptide is a Entity, GDSP is a Entity, cerulein is a Entity, GDSP is a Entity, nuclear factor KB is a Entity, NF - KB is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, N - formyl - methionine - leucine - phenyl - alanine is a Entity, fMLP is a Entity, GDSP is a Entity, GDSP is a Entity	357_task0	Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity	[ "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.	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guamerin - derived peptide is a Entity, guamerin - derived synthetic peptide is a Entity, GDSP is a Entity, cerulein is a Entity, GDSP is a Entity, nuclear factor KB is a Entity, NF - KB is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, N - formyl - methionine - leucine - phenyl - alanine is a Entity, fMLP is a Entity, GDSP is a Entity, GDSP is a Entity	357_task1	Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please typing these entity words according to sentence: guamerin - derived peptide, guamerin - derived synthetic peptide, GDSP, cerulein, GDSP, nuclear factor KB, NF - KB, GDSP, GDSP, GDSP, GDSP, N - formyl - methionine - leucine - phenyl - alanine, fMLP, GDSP, GDSP Options: Entity	[ "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.	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guamerin - derived peptide, guamerin - derived synthetic peptide, GDSP, cerulein, GDSP, nuclear factor KB, NF - KB, GDSP, GDSP, GDSP, GDSP, N - formyl - methionine - leucine - phenyl - alanine, fMLP, GDSP, GDSP	357_task2	Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.	[ "Amelioration", "of", "rat", "cerulein", "pancreatitis", "by", "guamerin", "-", "derived", "peptide", ",", "a", "novel", "elastase", "inhibitor", ".", "\n", "Increased", "activity", "of", "various", "proteases", "is", "observed", "in", "both", "human", "and", "experimental", "pancreatitis", ";", "however", ",", "the", "information", "on", "the", "effects", "of", "specific", "protease", "inhibitors", "on", "the", "disease", "is", "limited", ".", "In", "this", "study", "we", "show", "that", "a", "novel", "elastase", "inhibitor", ",", "guamerin", "-", "derived", "synthetic", "peptide", "(", "GDSP", ")", ",", "improves", "the", "parameters", "of", "cerulein", "-", "induced", "acute", "pancreatitis", "in", "the", "rat", ".", "The", "effects", "of", "GDSP", "on", "pancreatic", "weight", ",", "serum", "amylase", "and", "lipase", ",", "morphologic", "changes", "in", "the", "pancreas", ",", "neutrophil", "infiltration", ",", "and", "nuclear", "factor", "KB", "(", "NF", "-", "KB", ")", "activation", "were", "measured", "in", "rats", "infused", "with", "supramaximal", "dose", "of", "cerulein", "(", "5", "(", "g", "/", "kg", "/", "h", ")", "for", "6", "h.", "The", "effects", "of", "GDSP", "were", "also", "measured", "on", "superoxide", "formation", "by", "activated", "human", "neutrophils", ".", "The", "effects", "of", "GDSP", "were", "compared", "with", "those", "of", "another", "elastase", "inhibitor", ",", "elastatinal", ".", "GDSP", "significantly", "inhibited", "edema", "formation", ",", "neutrophil", "infiltration", ",", "acinar", "cell", "damage", ",", "and", "plasma", "lipase", "and", "amylase", "increases", "caused", "by", "cerulein", ".", "GDSP", "also", "completely", "inhibited", "superoxide", "formation", "in", "the", "human", "neutrophils", "stimulated", "by", "N", "-", "formyl", "-", "methionine", "-", "leucine", "-", "phenyl", "-", "alanine", "(", "fMLP", ")", "or", "12-O", "-", "tetradecanoylphorbol-13-acetate", "(", "TPA", ")", ".", "Elastatinal", "had", "some", "of", "the", "same", "effects", "as", "GDSP", "but", "was", "less", "potent", "and", "effective", ".", "These", "results", "demonstrate", "a", "beneficial", "effect", "of", "GDSP", ",", "a", "novel", "specific", "elastase", "inhibitor", ",", "on", "the", "development", "of", "rat", "cerulein", "pancreatitis", ".", "\n" ]	[ "Entity" ]
Pax5 is a protein_molecule, haploinsufficiency is an other_name, mammalian Pax genes is a DNA_family_or_group	34672_task0	Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, other_name, protein_molecule	[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]	Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?	[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]	[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]
Pax5 is a protein_molecule, haploinsufficiency is an other_name, mammalian Pax genes is a DNA_family_or_group	34672_task1	Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please typing these entity words according to sentence: Pax5, haploinsufficiency, mammalian Pax genes Options: DNA_family_or_group, other_name, protein_molecule	[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]	Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?	[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]	[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]
Pax5, haploinsufficiency, mammalian Pax genes	34672_task2	Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]	Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?	[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]	[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]
beta2 adrenergic receptors is a protein, glutathione is a compound, Nrf2 is a protein	DS.d1298_task0	Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.	[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]	[ "protein", "compound" ]
beta2 adrenergic receptors is a protein, glutathione is a compound, Nrf2 is a protein	DS.d1298_task1	Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please typing these entity words according to sentence: beta2 adrenergic receptors, glutathione, Nrf2 Options: compound, protein	[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.	[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]	[ "protein", "compound" ]
beta2 adrenergic receptors, glutathione, Nrf2	DS.d1298_task2	Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.	[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]	[ "protein", "compound" ]
quercetin content is a compound, kaempferol is a compound, F3'H is a protein	DS.d154_task0	Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.	[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]	[ "compound", "protein" ]
quercetin content is a compound, kaempferol is a compound, F3'H is a protein	DS.d154_task1	Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please typing these entity words according to sentence: quercetin content, kaempferol, F3'H Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.	[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]	[ "compound", "protein" ]
quercetin content, kaempferol, F3'H	DS.d154_task2	Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.	[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]	[ "compound", "protein" ]
Claudin-3 is a GENE-Y, claudin-4 is a GENE-Y, cisplatin is a CHEMICAL, copper and cisplatin influx transporter is a GENE-N, CTR1 is a GENE-Y	23053666_task0	Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL	[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]	Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.	[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Claudin-3 is a GENE-Y, claudin-4 is a GENE-Y, cisplatin is a CHEMICAL, copper and cisplatin influx transporter is a GENE-N, CTR1 is a GENE-Y	23053666_task1	Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please typing these entity words according to sentence: Claudin-3, claudin-4, cisplatin, copper and cisplatin influx transporter, CTR1 Options: GENE-N, GENE-Y, CHEMICAL	[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]	Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.	[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Claudin-3, claudin-4, cisplatin, copper and cisplatin influx transporter, CTR1	23053666_task2	Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please extract entity words from the input sentence	[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]	Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.	[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Komplikation is an umlsterm, vorderen Kreuzband is an umlsterm, Komplikation is an umlsterm, Verzoegerung is an umlsterm, Patientenselektion is an umlsterm, radiologischen is an umlsterm, Transplantatspannung is an umlsterm, Transplantatfixation is an umlsterm, Kniegelenks is an umlsterm, vorderen Kreuzband is an umlsterm	Arthroskopie.90120246.ger.abstr_task0	Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .	[ "Die", "Arthrofibrose", "ist", "eine", "bedeutende", "Komplikation", "nach", "Operationen", "am", "vorderen", "Kreuzband", ".", "Zur", "Prophylaxe", "dieser", "Komplikation", "dienen", "verschiedene", "prae-", ",", "intra-", "und", "postoperative", "Massnahmen", ".", "Praeoperative", "Massnahmen", "sind", "die", "Verzoegerung", "des", "Operationstermins", "bis", "zum", "Ende", "der", "inflammatorischen", "Phase", "nach", "dem", "Initialtrauma", ",", "ein", "praeoperatives", "Krankengymnastikprogramm", "sowie", "eine", "geeignete", "Patientenselektion", "und", "-aufklaerung", ".", "Intraoperative", "Massnahmen", "schliessen", "die", "exakte", "Plazierung", "der", "Bohrkanaele", "inklusive", "eines", "arthroskopischen", "und", "radiologischen", "Ausschlusses", "eines", "Transplantatimpingements", "ein", ".", "Weiterhin", "muss", "eine", "zu", "grosse", "Transplantatspannung", "zum", "Zeitpunkt", "der", "tibialen", "Transplantatfixation", "vermieden", "werden", ".", "Zu", "den", "postoperativen", "Massnahmen", "zaehlen", "die", "sofortige", "passive", "Strekkung", "des", "Kniegelenks", ",", "der", "fruehe", "Beginn", "eines", "Bewegungsprogramms", "und", "regelmaessige", "klinische", "Kontrollen", ".", "Aus", "der", "Erfahrung", "der", "eigenen", "Klinik", "kann", "bei", "Beruecksichtigung", "der", "genannten", "Massnahmen", "die", "Entwicklung", "einer", "Arthrofibrose", "nach", "Operationen", "am", "vorderen", "Kreuzband", "weitgehend", "vermieden", "werden", "." ]	[ "umlsterm" ]
Komplikation is an umlsterm, vorderen Kreuzband is an umlsterm, Komplikation is an umlsterm, Verzoegerung is an umlsterm, Patientenselektion is an umlsterm, radiologischen is an umlsterm, Transplantatspannung is an umlsterm, Transplantatfixation is an umlsterm, Kniegelenks is an umlsterm, vorderen Kreuzband is an umlsterm	Arthroskopie.90120246.ger.abstr_task1	Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please typing these entity words according to sentence: Komplikation, vorderen Kreuzband, Komplikation, Verzoegerung, Patientenselektion, radiologischen, Transplantatspannung, Transplantatfixation, Kniegelenks, vorderen Kreuzband Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .	[ "Die", "Arthrofibrose", "ist", "eine", "bedeutende", "Komplikation", "nach", "Operationen", "am", "vorderen", "Kreuzband", ".", "Zur", "Prophylaxe", "dieser", "Komplikation", "dienen", "verschiedene", "prae-", ",", "intra-", "und", "postoperative", "Massnahmen", ".", "Praeoperative", "Massnahmen", "sind", "die", "Verzoegerung", "des", "Operationstermins", "bis", "zum", "Ende", "der", "inflammatorischen", "Phase", "nach", "dem", "Initialtrauma", ",", "ein", "praeoperatives", "Krankengymnastikprogramm", "sowie", "eine", "geeignete", "Patientenselektion", "und", "-aufklaerung", ".", "Intraoperative", "Massnahmen", "schliessen", "die", "exakte", "Plazierung", "der", "Bohrkanaele", "inklusive", "eines", "arthroskopischen", "und", "radiologischen", "Ausschlusses", "eines", "Transplantatimpingements", "ein", ".", "Weiterhin", "muss", "eine", "zu", "grosse", "Transplantatspannung", "zum", "Zeitpunkt", "der", "tibialen", "Transplantatfixation", "vermieden", "werden", ".", "Zu", "den", "postoperativen", "Massnahmen", "zaehlen", "die", "sofortige", "passive", "Strekkung", "des", "Kniegelenks", ",", "der", "fruehe", "Beginn", "eines", "Bewegungsprogramms", "und", "regelmaessige", "klinische", "Kontrollen", ".", "Aus", "der", "Erfahrung", "der", "eigenen", "Klinik", "kann", "bei", "Beruecksichtigung", "der", "genannten", "Massnahmen", "die", "Entwicklung", "einer", "Arthrofibrose", "nach", "Operationen", "am", "vorderen", "Kreuzband", "weitgehend", "vermieden", "werden", "." ]	[ "umlsterm" ]
Komplikation, vorderen Kreuzband, Komplikation, Verzoegerung, Patientenselektion, radiologischen, Transplantatspannung, Transplantatfixation, Kniegelenks, vorderen Kreuzband	Arthroskopie.90120246.ger.abstr_task2	Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .	[ "Die", "Arthrofibrose", "ist", "eine", "bedeutende", "Komplikation", "nach", "Operationen", "am", "vorderen", "Kreuzband", ".", "Zur", "Prophylaxe", "dieser", "Komplikation", "dienen", "verschiedene", "prae-", ",", "intra-", "und", "postoperative", "Massnahmen", ".", "Praeoperative", "Massnahmen", "sind", "die", "Verzoegerung", "des", "Operationstermins", "bis", "zum", "Ende", "der", "inflammatorischen", "Phase", "nach", "dem", "Initialtrauma", ",", "ein", "praeoperatives", "Krankengymnastikprogramm", "sowie", "eine", "geeignete", "Patientenselektion", "und", "-aufklaerung", ".", "Intraoperative", "Massnahmen", "schliessen", "die", "exakte", "Plazierung", "der", "Bohrkanaele", "inklusive", "eines", "arthroskopischen", "und", "radiologischen", "Ausschlusses", "eines", "Transplantatimpingements", "ein", ".", "Weiterhin", "muss", "eine", "zu", "grosse", "Transplantatspannung", "zum", "Zeitpunkt", "der", "tibialen", "Transplantatfixation", "vermieden", "werden", ".", "Zu", "den", "postoperativen", "Massnahmen", "zaehlen", "die", "sofortige", "passive", "Strekkung", "des", "Kniegelenks", ",", "der", "fruehe", "Beginn", "eines", "Bewegungsprogramms", "und", "regelmaessige", "klinische", "Kontrollen", ".", "Aus", "der", "Erfahrung", "der", "eigenen", "Klinik", "kann", "bei", "Beruecksichtigung", "der", "genannten", "Massnahmen", "die", "Entwicklung", "einer", "Arthrofibrose", "nach", "Operationen", "am", "vorderen", "Kreuzband", "weitgehend", "vermieden", "werden", "." ]	[ "umlsterm" ]
Rehabilitation is an umlsterm, Praxis is an umlsterm, Fruehrehabilitation is an umlsterm, Akutkrankenhaus is an umlsterm, Rehabilitation is an umlsterm, Aktivbehandlung is an umlsterm, Rehabilitation is an umlsterm, Durchgangsarzt is an umlsterm, Rehabilitation is an umlsterm, Rehabilitation is an umlsterm, Hand is an umlsterm	Trauma+Berufskrankheit.0002s278.ger.abstr_task0	Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .	[ "Die", "Gesetze", "sehen", "eine", "fruehzeitige", "Vernetzung", "der", "umfassenden", "Rehabilitation", "vor", ".", "Diese", "Vorschriften", "werden", "in", "der", "Praxis", "nicht", "beachtet", ",", "was", "zur", "Folge", "hat", ",", "dass", "es", "fuer", "die", "Versicherten", "zu", "schlechten", "Ergebnissen", "kommt", ",", "die", "unnoetige", "Folgekosten", "von", "50.000", "DM", "und", "mehr", "verursachen", ",", "welche", "eingespart", "werden", "koennten", ".", "Das", "1", ".", "\"", "Rehabilitationsloch", "\"", "ist", ",", "dass", "es", "an", "einer", "Fruehrehabilitation", "im", "Akutkrankenhaus", "fehlt", ",", "das", "2", ".", ",", "dass", "eine", "Rehabilitation", "nach", "Aktivbehandlung", "gar", "nicht", ",", "zu", "spaet", "oder", "nicht", "umfassend", "stattfindet", ".", "Das", "3", ".", "\"", "Rehabilitationsloch", "\"", "ist", "dadurch", "charakterisiert", ",", "dass", "die", "medizinische", "Rehabilitation", "nicht", "berufsbezogen", "erfolgt", ",", "was", "dazu", "fuehrt", ",", "dass", "ein", "Beharrungszustand", "der", "Arbeitsunfaehigkeit", "ueber", "Monate", "hinweg", "eintritt", ".", "Die", "Rehabilitationsloecher", "\"", "\"", "koennten", "im", "Einzelfall", "dadurch", "vermieden", "werden", ",", "dass", "der", "Sachbearbeiter", "sich", "durch", "einen", "Facharzt", "fuer", "physikalische", "und", "Rehabilitationsmedizin", "beraten", "laesst", "und", "das", "Verfahren", "entsprechend", "steuert", ".", "Zukuenftig", "ist", "der", "Durchgangsarzt", "zum", "Thema", "Medizinische", "Rehabilitation", "aus-", "und", "weiterzubilden", ",", "damit", "er", "dann", "die", "medizinische", "Rehabilitation", "aus", "einer", "Hand", "steuern", "kann", "." ]	[ "umlsterm" ]
Rehabilitation is an umlsterm, Praxis is an umlsterm, Fruehrehabilitation is an umlsterm, Akutkrankenhaus is an umlsterm, Rehabilitation is an umlsterm, Aktivbehandlung is an umlsterm, Rehabilitation is an umlsterm, Durchgangsarzt is an umlsterm, Rehabilitation is an umlsterm, Rehabilitation is an umlsterm, Hand is an umlsterm	Trauma+Berufskrankheit.0002s278.ger.abstr_task1	Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please typing these entity words according to sentence: Rehabilitation, Praxis, Fruehrehabilitation, Akutkrankenhaus, Rehabilitation, Aktivbehandlung, Rehabilitation, Durchgangsarzt, Rehabilitation, Rehabilitation, Hand Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .	[ "Die", "Gesetze", "sehen", "eine", "fruehzeitige", "Vernetzung", "der", "umfassenden", "Rehabilitation", "vor", ".", "Diese", "Vorschriften", "werden", "in", "der", "Praxis", "nicht", "beachtet", ",", "was", "zur", "Folge", "hat", ",", "dass", "es", "fuer", "die", "Versicherten", "zu", "schlechten", "Ergebnissen", "kommt", ",", "die", "unnoetige", "Folgekosten", "von", "50.000", "DM", "und", "mehr", "verursachen", ",", "welche", "eingespart", "werden", "koennten", ".", "Das", "1", ".", "\"", "Rehabilitationsloch", "\"", "ist", ",", "dass", "es", "an", "einer", "Fruehrehabilitation", "im", "Akutkrankenhaus", "fehlt", ",", "das", "2", ".", ",", "dass", "eine", "Rehabilitation", "nach", "Aktivbehandlung", "gar", "nicht", ",", "zu", "spaet", "oder", "nicht", "umfassend", "stattfindet", ".", "Das", "3", ".", "\"", "Rehabilitationsloch", "\"", "ist", "dadurch", "charakterisiert", ",", "dass", "die", "medizinische", "Rehabilitation", "nicht", "berufsbezogen", "erfolgt", ",", "was", "dazu", "fuehrt", ",", "dass", "ein", "Beharrungszustand", "der", "Arbeitsunfaehigkeit", "ueber", "Monate", "hinweg", "eintritt", ".", "Die", "Rehabilitationsloecher", "\"", "\"", "koennten", "im", "Einzelfall", "dadurch", "vermieden", "werden", ",", "dass", "der", "Sachbearbeiter", "sich", "durch", "einen", "Facharzt", "fuer", "physikalische", "und", "Rehabilitationsmedizin", "beraten", "laesst", "und", "das", "Verfahren", "entsprechend", "steuert", ".", "Zukuenftig", "ist", "der", "Durchgangsarzt", "zum", "Thema", "Medizinische", "Rehabilitation", "aus-", "und", "weiterzubilden", ",", "damit", "er", "dann", "die", "medizinische", "Rehabilitation", "aus", "einer", "Hand", "steuern", "kann", "." ]	[ "umlsterm" ]
Rehabilitation, Praxis, Fruehrehabilitation, Akutkrankenhaus, Rehabilitation, Aktivbehandlung, Rehabilitation, Durchgangsarzt, Rehabilitation, Rehabilitation, Hand	Trauma+Berufskrankheit.0002s278.ger.abstr_task2	Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .	[ "Die", "Gesetze", "sehen", "eine", "fruehzeitige", "Vernetzung", "der", "umfassenden", "Rehabilitation", "vor", ".", "Diese", "Vorschriften", "werden", "in", "der", "Praxis", "nicht", "beachtet", ",", "was", "zur", "Folge", "hat", ",", "dass", "es", "fuer", "die", "Versicherten", "zu", "schlechten", "Ergebnissen", "kommt", ",", "die", "unnoetige", "Folgekosten", "von", "50.000", "DM", "und", "mehr", "verursachen", ",", "welche", "eingespart", "werden", "koennten", ".", "Das", "1", ".", "\"", "Rehabilitationsloch", "\"", "ist", ",", "dass", "es", "an", "einer", "Fruehrehabilitation", "im", "Akutkrankenhaus", "fehlt", ",", "das", "2", ".", ",", "dass", "eine", "Rehabilitation", "nach", "Aktivbehandlung", "gar", "nicht", ",", "zu", "spaet", "oder", "nicht", "umfassend", "stattfindet", ".", "Das", "3", ".", "\"", "Rehabilitationsloch", "\"", "ist", "dadurch", "charakterisiert", ",", "dass", "die", "medizinische", "Rehabilitation", "nicht", "berufsbezogen", "erfolgt", ",", "was", "dazu", "fuehrt", ",", "dass", "ein", "Beharrungszustand", "der", "Arbeitsunfaehigkeit", "ueber", "Monate", "hinweg", "eintritt", ".", "Die", "Rehabilitationsloecher", "\"", "\"", "koennten", "im", "Einzelfall", "dadurch", "vermieden", "werden", ",", "dass", "der", "Sachbearbeiter", "sich", "durch", "einen", "Facharzt", "fuer", "physikalische", "und", "Rehabilitationsmedizin", "beraten", "laesst", "und", "das", "Verfahren", "entsprechend", "steuert", ".", "Zukuenftig", "ist", "der", "Durchgangsarzt", "zum", "Thema", "Medizinische", "Rehabilitation", "aus-", "und", "weiterzubilden", ",", "damit", "er", "dann", "die", "medizinische", "Rehabilitation", "aus", "einer", "Hand", "steuern", "kann", "." ]	[ "umlsterm" ]
K+ channels is a protein_family_or_group, Ca2 + signaling is an other_name, gene expression is an other_name, T lymphocytes is a cell_type	72968_task0	Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, other_name	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.	[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]	[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]
K+ channels is a protein_family_or_group, Ca2 + signaling is an other_name, gene expression is an other_name, T lymphocytes is a cell_type	72968_task1	Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please typing these entity words according to sentence: K+ channels, Ca2 + signaling, gene expression, T lymphocytes Options: cell_type, protein_family_or_group, other_name	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.	[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]	[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]
K+ channels, Ca2 + signaling, gene expression, T lymphocytes	72968_task2	Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]	A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.	[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]	[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]
vein is an umlsterm, limb is an umlsterm, ischemia is an umlsterm, All is an umlsterm, patients is an umlsterm, program is an umlsterm, patients is an umlsterm, patients is an umlsterm, diabetes is an umlsterm, patients is an umlsterm, diabetes mellitus is an umlsterm, sex is an umlsterm, age is an umlsterm, limb is an umlsterm, limb is an umlsterm, limb is an umlsterm, amputations is an umlsterm, amputation is an umlsterm, foot is an umlsterm, infection is an umlsterm	Gefaesschirurgie.90040040.eng.abstr_task0	Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .	[ "In", "the", "last", "7", "years", "we", "have", "performed", "220", "infrainguinal", "vein", "bypasses", "associated", "with", "critical", "limb", "ischemia", ".", "All", "patients", "were", "prospectively", "controlled", "in", "a", "follow", "-", "up", "program", "3", "-", "72", "months", "postoperatively", ".", "The", "patients", "were", "divided", "into", "two", "groups", ":", "patients", "with", "diabetes", "mellitus", "(", "35", "%", ",", "group", "1", ")", "and", "patients", "without", "diabetes", "mellitus", "(", "65", "%", ",", "group", "2", ")", ".", "There", "was", "no", "difference", "in", "sex", ",", "age", "or", "localization", "of", "distal", "anastomosis", "(", "supra-", "or", "infragenicular", ")", "between", "the", "two", "groups", ".", "The", "primary", "and", "the", "primary", "-", "assisted", "patency", "rates", "were", "not", "statistically", "different", "after", "60", "months", ".", "There", "was", "a", "significant", "difference", "in", "limb", "salvage", ".", "The", "limb", "salvage", "of", "group", "1", "was", "75", "%", "after", "60", "months", ",", "while", "the", "limb", "salvage", "of", "group", "2", "was", "95", "%", "(", "P", "=", "0.0045", ")", ".", "The", "rate", "of", "major", "amputations", "was", "significantly", "higher", "in", "group", "1", "(", "15.6", "%", ")", "than", "in", "group", "2", "(", "4.9", "%", ",", "P", "=", "0.007", ")", ".", "The", "indication", "for", "amputation", "was", "persistent", "foot", "infection", "." ]	[ "umlsterm" ]
vein is an umlsterm, limb is an umlsterm, ischemia is an umlsterm, All is an umlsterm, patients is an umlsterm, program is an umlsterm, patients is an umlsterm, patients is an umlsterm, diabetes is an umlsterm, patients is an umlsterm, diabetes mellitus is an umlsterm, sex is an umlsterm, age is an umlsterm, limb is an umlsterm, limb is an umlsterm, limb is an umlsterm, amputations is an umlsterm, amputation is an umlsterm, foot is an umlsterm, infection is an umlsterm	Gefaesschirurgie.90040040.eng.abstr_task1	Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please typing these entity words according to sentence: vein, limb, ischemia, All, patients, program, patients, patients, diabetes, patients, diabetes mellitus, sex, age, limb, limb, limb, amputations, amputation, foot, infection Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .	[ "In", "the", "last", "7", "years", "we", "have", "performed", "220", "infrainguinal", "vein", "bypasses", "associated", "with", "critical", "limb", "ischemia", ".", "All", "patients", "were", "prospectively", "controlled", "in", "a", "follow", "-", "up", "program", "3", "-", "72", "months", "postoperatively", ".", "The", "patients", "were", "divided", "into", "two", "groups", ":", "patients", "with", "diabetes", "mellitus", "(", "35", "%", ",", "group", "1", ")", "and", "patients", "without", "diabetes", "mellitus", "(", "65", "%", ",", "group", "2", ")", ".", "There", "was", "no", "difference", "in", "sex", ",", "age", "or", "localization", "of", "distal", "anastomosis", "(", "supra-", "or", "infragenicular", ")", "between", "the", "two", "groups", ".", "The", "primary", "and", "the", "primary", "-", "assisted", "patency", "rates", "were", "not", "statistically", "different", "after", "60", "months", ".", "There", "was", "a", "significant", "difference", "in", "limb", "salvage", ".", "The", "limb", "salvage", "of", "group", "1", "was", "75", "%", "after", "60", "months", ",", "while", "the", "limb", "salvage", "of", "group", "2", "was", "95", "%", "(", "P", "=", "0.0045", ")", ".", "The", "rate", "of", "major", "amputations", "was", "significantly", "higher", "in", "group", "1", "(", "15.6", "%", ")", "than", "in", "group", "2", "(", "4.9", "%", ",", "P", "=", "0.007", ")", ".", "The", "indication", "for", "amputation", "was", "persistent", "foot", "infection", "." ]	[ "umlsterm" ]
vein, limb, ischemia, All, patients, program, patients, patients, diabetes, patients, diabetes mellitus, sex, age, limb, limb, limb, amputations, amputation, foot, infection	Gefaesschirurgie.90040040.eng.abstr_task2	Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .	[ "In", "the", "last", "7", "years", "we", "have", "performed", "220", "infrainguinal", "vein", "bypasses", "associated", "with", "critical", "limb", "ischemia", ".", "All", "patients", "were", "prospectively", "controlled", "in", "a", "follow", "-", "up", "program", "3", "-", "72", "months", "postoperatively", ".", "The", "patients", "were", "divided", "into", "two", "groups", ":", "patients", "with", "diabetes", "mellitus", "(", "35", "%", ",", "group", "1", ")", "and", "patients", "without", "diabetes", "mellitus", "(", "65", "%", ",", "group", "2", ")", ".", "There", "was", "no", "difference", "in", "sex", ",", "age", "or", "localization", "of", "distal", "anastomosis", "(", "supra-", "or", "infragenicular", ")", "between", "the", "two", "groups", ".", "The", "primary", "and", "the", "primary", "-", "assisted", "patency", "rates", "were", "not", "statistically", "different", "after", "60", "months", ".", "There", "was", "a", "significant", "difference", "in", "limb", "salvage", ".", "The", "limb", "salvage", "of", "group", "1", "was", "75", "%", "after", "60", "months", ",", "while", "the", "limb", "salvage", "of", "group", "2", "was", "95", "%", "(", "P", "=", "0.0045", ")", ".", "The", "rate", "of", "major", "amputations", "was", "significantly", "higher", "in", "group", "1", "(", "15.6", "%", ")", "than", "in", "group", "2", "(", "4.9", "%", ",", "P", "=", "0.007", ")", ".", "The", "indication", "for", "amputation", "was", "persistent", "foot", "infection", "." ]	[ "umlsterm" ]
Healthy is a Condition, male is a Person, female is a Person, adolescents is a Person, age is a Person, 12 to 17 years is a Value, at Screening is a Temporal, body mass index ( BMI ) is a Measurement, greater than or equal to the United States - weighted mean of the 95th percentile is a Value, based on age and sex is a Scope, body weight is a Measurement, greater than 60 kilograms ( kg ) is a Value, HbA1c is a Measurement, = 6.5 % is a Value, fasting plasma glucose ( FPG ) is a Measurement, = 126 mg / dL is a Value, 7.0 mmol / L is a Value, not is a Negation, planning to move away is a Observation, for the duration of the study is a Temporal, able and willing to comply is a Scope, standardized , reduced calorie diet and an age appropriate , increased physical activity program is a Scope, stable health is a Observation, Able and willing to personally comply is a Scope, caregivers or guardians is a Scope	NCT03338296_inc_task0	Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Observation, Negation, Scope, Measurement	[ "B-Condition", "B-Person", "O", "B-Person", "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O" ]	Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians	[ "Healthy", "male", "or", "female", "adolescents", ",", "age", "12", "to", "17", "years", "(", "inclusive", ")", "at", "Screening", ",", "with", "a", "body", "mass", "index", "(", "BMI", ")", "that", "is", "greater", "than", "or", "equal", "to", "the", "United", "States", "-", "weighted", "mean", "of", "the", "95th", "percentile", "based", "on", "age", "and", "sex", "with", "a", "body", "weight", "greater", "than", "60", "kilograms", "(", "kg", ")", ".", "Participants", "with", "Type", "2", "diabetes", "mellitus", "(", "T2DM", ")", "may", "have", "a", "pre", "-", "existing", "or", "new", "diagnosis", "of", "T2DM", ".", "\n", "HbA1c", "=", "6.5", "%", "\n", "fasting", "plasma", "glucose", "(", "FPG", ")", "=", "126", "mg", "/", "dL", "(", "7.0", "mmol", "/", "L", ")", "\n", "Participants", "and", "their", "families", "not", "planning", "to", "move", "away", "from", "the", "area", "for", "the", "duration", "of", "the", "study", "\n", "Participants", "able", "and", "willing", "to", "comply", "with", "all", "aspects", "of", "the", "study", ",", "including", "a", "standardized", ",", "reduced", "calorie", "diet", "and", "an", "age", "appropriate", ",", "increased", "physical", "activity", "program", "\n", "Participants", "considered", "in", "stable", "health", "in", "the", "opinion", "of", "the", "investigator", "\n", "Able", "and", "willing", "to", "support", "and", "supervise", "study", "participation", "in", "the", "opinion", "of", "the", "investigator", ",", "including", "consideration", "of", "any", "existing", "physical", ",", "medical", ",", "or", "mental", "condition", "that", "prevents", "compliance", "with", "the", "protocol", "\n", "Able", "and", "willing", "to", "personally", "comply", "with", "and", "execute", "all", "aspects", "of", "the", "study", "requirements", "for", "the", "caregivers", "or", "guardians", "\n" ]	[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]
Healthy is a Condition, male is a Person, female is a Person, adolescents is a Person, age is a Person, 12 to 17 years is a Value, at Screening is a Temporal, body mass index ( BMI ) is a Measurement, greater than or equal to the United States - weighted mean of the 95th percentile is a Value, based on age and sex is a Scope, body weight is a Measurement, greater than 60 kilograms ( kg ) is a Value, HbA1c is a Measurement, = 6.5 % is a Value, fasting plasma glucose ( FPG ) is a Measurement, = 126 mg / dL is a Value, 7.0 mmol / L is a Value, not is a Negation, planning to move away is a Observation, for the duration of the study is a Temporal, able and willing to comply is a Scope, standardized , reduced calorie diet and an age appropriate , increased physical activity program is a Scope, stable health is a Observation, Able and willing to personally comply is a Scope, caregivers or guardians is a Scope	NCT03338296_inc_task1	Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please typing these entity words according to sentence: Healthy, male, female, adolescents, age, 12 to 17 years, at Screening, body mass index ( BMI ), greater than or equal to the United States - weighted mean of the 95th percentile, based on age and sex, body weight, greater than 60 kilograms ( kg ), HbA1c, = 6.5 %, fasting plasma glucose ( FPG ), = 126 mg / dL, 7.0 mmol / L, not, planning to move away, for the duration of the study, able and willing to comply, standardized , reduced calorie diet and an age appropriate , increased physical activity program, stable health, Able and willing to personally comply, caregivers or guardians Options: Temporal, Condition, Value, Person, Observation, Negation, Scope, Measurement	[ "B-Condition", "B-Person", "O", "B-Person", "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O" ]	Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians	[ "Healthy", "male", "or", "female", "adolescents", ",", "age", "12", "to", "17", "years", "(", "inclusive", ")", "at", "Screening", ",", "with", "a", "body", "mass", "index", "(", "BMI", ")", "that", "is", "greater", "than", "or", "equal", "to", "the", "United", "States", "-", "weighted", "mean", "of", "the", "95th", "percentile", "based", "on", "age", "and", "sex", "with", "a", "body", "weight", "greater", "than", "60", "kilograms", "(", "kg", ")", ".", "Participants", "with", "Type", "2", "diabetes", "mellitus", "(", "T2DM", ")", "may", "have", "a", "pre", "-", "existing", "or", "new", "diagnosis", "of", "T2DM", ".", "\n", "HbA1c", "=", "6.5", "%", "\n", "fasting", "plasma", "glucose", "(", "FPG", ")", "=", "126", "mg", "/", "dL", "(", "7.0", "mmol", "/", "L", ")", "\n", "Participants", "and", "their", "families", "not", "planning", "to", "move", "away", "from", "the", "area", "for", "the", "duration", "of", "the", "study", "\n", "Participants", "able", "and", "willing", "to", "comply", "with", "all", "aspects", "of", "the", "study", ",", "including", "a", "standardized", ",", "reduced", "calorie", "diet", "and", "an", "age", "appropriate", ",", "increased", "physical", "activity", "program", "\n", "Participants", "considered", "in", "stable", "health", "in", "the", "opinion", "of", "the", "investigator", "\n", "Able", "and", "willing", "to", "support", "and", "supervise", "study", "participation", "in", "the", "opinion", "of", "the", "investigator", ",", "including", "consideration", "of", "any", "existing", "physical", ",", "medical", ",", "or", "mental", "condition", "that", "prevents", "compliance", "with", "the", "protocol", "\n", "Able", "and", "willing", "to", "personally", "comply", "with", "and", "execute", "all", "aspects", "of", "the", "study", "requirements", "for", "the", "caregivers", "or", "guardians", "\n" ]	[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]
Healthy, male, female, adolescents, age, 12 to 17 years, at Screening, body mass index ( BMI ), greater than or equal to the United States - weighted mean of the 95th percentile, based on age and sex, body weight, greater than 60 kilograms ( kg ), HbA1c, = 6.5 %, fasting plasma glucose ( FPG ), = 126 mg / dL, 7.0 mmol / L, not, planning to move away, for the duration of the study, able and willing to comply, standardized , reduced calorie diet and an age appropriate , increased physical activity program, stable health, Able and willing to personally comply, caregivers or guardians	NCT03338296_inc_task2	Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please extract entity words from the input sentence	[ "B-Condition", "B-Person", "O", "B-Person", "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O" ]	Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians	[ "Healthy", "male", "or", "female", "adolescents", ",", "age", "12", "to", "17", "years", "(", "inclusive", ")", "at", "Screening", ",", "with", "a", "body", "mass", "index", "(", "BMI", ")", "that", "is", "greater", "than", "or", "equal", "to", "the", "United", "States", "-", "weighted", "mean", "of", "the", "95th", "percentile", "based", "on", "age", "and", "sex", "with", "a", "body", "weight", "greater", "than", "60", "kilograms", "(", "kg", ")", ".", "Participants", "with", "Type", "2", "diabetes", "mellitus", "(", "T2DM", ")", "may", "have", "a", "pre", "-", "existing", "or", "new", "diagnosis", "of", "T2DM", ".", "\n", "HbA1c", "=", "6.5", "%", "\n", "fasting", "plasma", "glucose", "(", "FPG", ")", "=", "126", "mg", "/", "dL", "(", "7.0", "mmol", "/", "L", ")", "\n", "Participants", "and", "their", "families", "not", "planning", "to", "move", "away", "from", "the", "area", "for", "the", "duration", "of", "the", "study", "\n", "Participants", "able", "and", "willing", "to", "comply", "with", "all", "aspects", "of", "the", "study", ",", "including", "a", "standardized", ",", "reduced", "calorie", "diet", "and", "an", "age", "appropriate", ",", "increased", "physical", "activity", "program", "\n", "Participants", "considered", "in", "stable", "health", "in", "the", "opinion", "of", "the", "investigator", "\n", "Able", "and", "willing", "to", "support", "and", "supervise", "study", "participation", "in", "the", "opinion", "of", "the", "investigator", ",", "including", "consideration", "of", "any", "existing", "physical", ",", "medical", ",", "or", "mental", "condition", "that", "prevents", "compliance", "with", "the", "protocol", "\n", "Able", "and", "willing", "to", "personally", "comply", "with", "and", "execute", "all", "aspects", "of", "the", "study", "requirements", "for", "the", "caregivers", "or", "guardians", "\n" ]	[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]
Infektionsprophylaxe is an umlsterm, hygienegerechtem is an umlsterm, Verhalten is an umlsterm, Boden is an umlsterm, Zeitplanung is an umlsterm, Technik is an umlsterm, Verhaltens is an umlsterm, Operationstechnik is an umlsterm, Hygiene is an umlsterm, Hand is an umlsterm, Infektionsstatistik is an umlsterm, Personals is an umlsterm, Patienten is an umlsterm, Infektionen is an umlsterm	DerChirurg.60671123.ger.abstr_task0	Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .	[ "Zusammenfassung", ".", "Perioperative", "Infektionsprophylaxe", "stellt", "ein", "Zusammenspiel", "aus", "technischem", "Equipment", ",", "gutem", "Operieren", "und", "hygienegerechtem", "Verhalten", "dar", ".", "Der", "Boden", ",", "auf", "dem", "dies", "waechst", ",", "ist", "ein", "ueberschaubarer", ",", "gut", "organisierter", "Betrieb", "mit", "bekannten", ",", "allgemein", "eingeuebten", "Funktionsablaeufen", "und", "mit", "einer", "soliden", ",", "einhaltbaren", "Zeitplanung", ".", "Die", "wichtigste", "Technik", "zur", "Ueberwachung", "und", "Verbesserung", "des", "Verhaltens", "(", "hinsichtlich", "Operationstechnik", "und", "Hygiene", ")", "ist", "das", "Vorbild", ",", "das", "Anwesend", "-", "sein", "(", "\"", "Inter", "-", "esse", "\"", ")", ".", "Hierbei", "werden", "gleichzeitig", "Detailfehler", "erkannt", ".", "Darueber", "hinaus", "dient", "zur", "Erfolgskontrolle", "(", "bzw", ".", "Misserfolgskontrolle", ")", "eine", "langfristig", "ehrlich", "und", "in", "einer", "Hand", "gefuehrte", "Infektionsstatistik", ",", "welche", "sich", "vorrangig", "mit", "den", "intern", "beeinflussbaren", "Faktoren", "zu", "beschaeftigen", "hat", "und", "welche", "zur", "externen", "Praesentation", "in", "der", "Regel", "nicht", "taugt", ".", "Dem", "Schutz", "des", "Personals", "kommt", "der", "selbe", "hohe", "Stellenwert", "zu", "wie", "dem", "Schutz", "der", "Patienten", "vor", "Infektionen", ".", "Ob", "antibiotische", "routinemaessige", "Prophylaxemassnahmen", "in", "der", "Unfallchirurgie", "unter", "heutigen", "Bedingungen", "eine", "Berechtigung", "haben", ",", "ist", "im", "Augenblick", "theoretisch", "nicht", "geklaert", "." ]	[ "umlsterm" ]
Infektionsprophylaxe is an umlsterm, hygienegerechtem is an umlsterm, Verhalten is an umlsterm, Boden is an umlsterm, Zeitplanung is an umlsterm, Technik is an umlsterm, Verhaltens is an umlsterm, Operationstechnik is an umlsterm, Hygiene is an umlsterm, Hand is an umlsterm, Infektionsstatistik is an umlsterm, Personals is an umlsterm, Patienten is an umlsterm, Infektionen is an umlsterm	DerChirurg.60671123.ger.abstr_task1	Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please typing these entity words according to sentence: Infektionsprophylaxe, hygienegerechtem, Verhalten, Boden, Zeitplanung, Technik, Verhaltens, Operationstechnik, Hygiene, Hand, Infektionsstatistik, Personals, Patienten, Infektionen Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .	[ "Zusammenfassung", ".", "Perioperative", "Infektionsprophylaxe", "stellt", "ein", "Zusammenspiel", "aus", "technischem", "Equipment", ",", "gutem", "Operieren", "und", "hygienegerechtem", "Verhalten", "dar", ".", "Der", "Boden", ",", "auf", "dem", "dies", "waechst", ",", "ist", "ein", "ueberschaubarer", ",", "gut", "organisierter", "Betrieb", "mit", "bekannten", ",", "allgemein", "eingeuebten", "Funktionsablaeufen", "und", "mit", "einer", "soliden", ",", "einhaltbaren", "Zeitplanung", ".", "Die", "wichtigste", "Technik", "zur", "Ueberwachung", "und", "Verbesserung", "des", "Verhaltens", "(", "hinsichtlich", "Operationstechnik", "und", "Hygiene", ")", "ist", "das", "Vorbild", ",", "das", "Anwesend", "-", "sein", "(", "\"", "Inter", "-", "esse", "\"", ")", ".", "Hierbei", "werden", "gleichzeitig", "Detailfehler", "erkannt", ".", "Darueber", "hinaus", "dient", "zur", "Erfolgskontrolle", "(", "bzw", ".", "Misserfolgskontrolle", ")", "eine", "langfristig", "ehrlich", "und", "in", "einer", "Hand", "gefuehrte", "Infektionsstatistik", ",", "welche", "sich", "vorrangig", "mit", "den", "intern", "beeinflussbaren", "Faktoren", "zu", "beschaeftigen", "hat", "und", "welche", "zur", "externen", "Praesentation", "in", "der", "Regel", "nicht", "taugt", ".", "Dem", "Schutz", "des", "Personals", "kommt", "der", "selbe", "hohe", "Stellenwert", "zu", "wie", "dem", "Schutz", "der", "Patienten", "vor", "Infektionen", ".", "Ob", "antibiotische", "routinemaessige", "Prophylaxemassnahmen", "in", "der", "Unfallchirurgie", "unter", "heutigen", "Bedingungen", "eine", "Berechtigung", "haben", ",", "ist", "im", "Augenblick", "theoretisch", "nicht", "geklaert", "." ]	[ "umlsterm" ]
Infektionsprophylaxe, hygienegerechtem, Verhalten, Boden, Zeitplanung, Technik, Verhaltens, Operationstechnik, Hygiene, Hand, Infektionsstatistik, Personals, Patienten, Infektionen	DerChirurg.60671123.ger.abstr_task2	Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .	[ "Zusammenfassung", ".", "Perioperative", "Infektionsprophylaxe", "stellt", "ein", "Zusammenspiel", "aus", "technischem", "Equipment", ",", "gutem", "Operieren", "und", "hygienegerechtem", "Verhalten", "dar", ".", "Der", "Boden", ",", "auf", "dem", "dies", "waechst", ",", "ist", "ein", "ueberschaubarer", ",", "gut", "organisierter", "Betrieb", "mit", "bekannten", ",", "allgemein", "eingeuebten", "Funktionsablaeufen", "und", "mit", "einer", "soliden", ",", "einhaltbaren", "Zeitplanung", ".", "Die", "wichtigste", "Technik", "zur", "Ueberwachung", "und", "Verbesserung", "des", "Verhaltens", "(", "hinsichtlich", "Operationstechnik", "und", "Hygiene", ")", "ist", "das", "Vorbild", ",", "das", "Anwesend", "-", "sein", "(", "\"", "Inter", "-", "esse", "\"", ")", ".", "Hierbei", "werden", "gleichzeitig", "Detailfehler", "erkannt", ".", "Darueber", "hinaus", "dient", "zur", "Erfolgskontrolle", "(", "bzw", ".", "Misserfolgskontrolle", ")", "eine", "langfristig", "ehrlich", "und", "in", "einer", "Hand", "gefuehrte", "Infektionsstatistik", ",", "welche", "sich", "vorrangig", "mit", "den", "intern", "beeinflussbaren", "Faktoren", "zu", "beschaeftigen", "hat", "und", "welche", "zur", "externen", "Praesentation", "in", "der", "Regel", "nicht", "taugt", ".", "Dem", "Schutz", "des", "Personals", "kommt", "der", "selbe", "hohe", "Stellenwert", "zu", "wie", "dem", "Schutz", "der", "Patienten", "vor", "Infektionen", ".", "Ob", "antibiotische", "routinemaessige", "Prophylaxemassnahmen", "in", "der", "Unfallchirurgie", "unter", "heutigen", "Bedingungen", "eine", "Berechtigung", "haben", ",", "ist", "im", "Augenblick", "theoretisch", "nicht", "geklaert", "." ]	[ "umlsterm" ]
development is an umlsterm, septorhinoplasty is an umlsterm, developments is an umlsterm, surgery is an umlsterm, open is an umlsterm, septorhinoplasty is an umlsterm, surgery is an umlsterm	HNO.00480562.eng.abstr_task0	Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .	[ "Looking", "back", "at", "150", "years", "of", "the", "development", "of", "septorhinoplasty", "-", "50", "of", "which", "I", "have", "experienced", "myself", "-", "one", "can", "conclude", "that", "recent", "developments", "go", "back", "to", "the", "nineteenth", "century", ".", "In", "the", "era", "of", "\"", "minimal", "invasive", "surgery", "\"", "the", "\"", "open", "approach", "\"", "to", "septorhinoplasty", "should", "no", "longer", "be", "indicated", ".", "The", "sublabial", "approach", "in", "the", "sense", "of", "minimal", "invasive", "surgery", "is", "recommended", "." ]	[ "umlsterm" ]
development is an umlsterm, septorhinoplasty is an umlsterm, developments is an umlsterm, surgery is an umlsterm, open is an umlsterm, septorhinoplasty is an umlsterm, surgery is an umlsterm	HNO.00480562.eng.abstr_task1	Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please typing these entity words according to sentence: development, septorhinoplasty, developments, surgery, open, septorhinoplasty, surgery Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .	[ "Looking", "back", "at", "150", "years", "of", "the", "development", "of", "septorhinoplasty", "-", "50", "of", "which", "I", "have", "experienced", "myself", "-", "one", "can", "conclude", "that", "recent", "developments", "go", "back", "to", "the", "nineteenth", "century", ".", "In", "the", "era", "of", "\"", "minimal", "invasive", "surgery", "\"", "the", "\"", "open", "approach", "\"", "to", "septorhinoplasty", "should", "no", "longer", "be", "indicated", ".", "The", "sublabial", "approach", "in", "the", "sense", "of", "minimal", "invasive", "surgery", "is", "recommended", "." ]	[ "umlsterm" ]
development, septorhinoplasty, developments, surgery, open, septorhinoplasty, surgery	HNO.00480562.eng.abstr_task2	Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .	[ "Looking", "back", "at", "150", "years", "of", "the", "development", "of", "septorhinoplasty", "-", "50", "of", "which", "I", "have", "experienced", "myself", "-", "one", "can", "conclude", "that", "recent", "developments", "go", "back", "to", "the", "nineteenth", "century", ".", "In", "the", "era", "of", "\"", "minimal", "invasive", "surgery", "\"", "the", "\"", "open", "approach", "\"", "to", "septorhinoplasty", "should", "no", "longer", "be", "indicated", ".", "The", "sublabial", "approach", "in", "the", "sense", "of", "minimal", "invasive", "surgery", "is", "recommended", "." ]	[ "umlsterm" ]
sexuell uebertragbaren Krankheiten is an umlsterm, Stadt is an umlsterm, Ruhr - Universitaet is an umlsterm, Beratung is an umlsterm, Geschlechtskranken is an umlsterm, anonyme is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Deutschland is an umlsterm, Frauen is an umlsterm, Kondome is an umlsterm, Kondome is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Gesundheitsbewusstsein is an umlsterm, Risikobereitschaft is an umlsterm, Frauen is an umlsterm	DerHautarzt.70480166.ger.abstr_task0	Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .	[ "Regelmaessige", "Untersuchungen", "von", "Prostituierten", "sind", "eine", "Moeglichkeit", "der", "Praevention", "von", "sexuell", "uebertragbaren", "Krankheiten", "(", "STD", ")", "in", "dieser", "Risikogruppe", ".", "Seit", "dem", "1.4.1988", "wird", "im", "Gesundheitsamt", "der", "Stadt", "Bochum", "in", "Kooperation", "mit", "der", "Dermatologischen", "Klinik", "der", "Ruhr", "-", "Universitaet", "Bochum", "eine", "Sprechstunde", "zur", "Beratung", "und", "Untersuchung", "von", "Geschlechtskranken", "angeboten", ".", "Ziel", "der", "vorliegenden", "Studie", "war", "es", ",", "die", "Effektivitaet", "und", "Akzeptanz", "dieser", "Einrichtung", "zu", "ueberpruefen", ".", "Aus", "diesem", "Grund", "wurden", "anonyme", "Frageboegen", "ausgelegt", ",", "die", "von", "80", "Frauen", "beantwortet", "wurden", ".", "Der", "Altersdurchschnitt", "lag", "bei", "31,4", "Jahren", ".", "67", "Frauen", "stammten", "aus", "Deutschland", ".", "78", "der", "80", "Frauen", "benutzten", "immer", "Kondome", ",", "71", "glaubten", "an", "einen", "Gesundheitsschutz", "durch", "Kondome", ".", "3", "der", "80", "Frauen", "gaben", "an", ",", "in", "den", "letzten", "12", "Monaten", "an", "einer", "STD", "erkrankt", "zu", "sein", ".", "75", "der", "80", "Frauen", "empfanden", "die", "Untersuchung", "ausdruecklich", "nicht", "als", "diskriminierend", ";", "71", "beurteilten", "die", "Qualitaet", "der", "Untersuchungen", "als", "gut", ".", "Aus", "diesen", "Ergebnissen", "laesst", "sich", "ableiten", ",", "dass", "die", "von", "Dermatologen", "im", "Gesundheitsamt", "durchgefuehrten", "regelmaessigen", ",", "obligatorischen", "Untersuchungen", "zu", "einem", "hohen", "Gesundheitsbewusstsein", "mit", "geringer", "Risikobereitschaft", "gefuehrt", "haben", "und", "von", "den", "Frauen", "gut", "akzeptiert", "werden", "." ]	[ "umlsterm" ]
sexuell uebertragbaren Krankheiten is an umlsterm, Stadt is an umlsterm, Ruhr - Universitaet is an umlsterm, Beratung is an umlsterm, Geschlechtskranken is an umlsterm, anonyme is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Deutschland is an umlsterm, Frauen is an umlsterm, Kondome is an umlsterm, Kondome is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Gesundheitsbewusstsein is an umlsterm, Risikobereitschaft is an umlsterm, Frauen is an umlsterm	DerHautarzt.70480166.ger.abstr_task1	Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please typing these entity words according to sentence: sexuell uebertragbaren Krankheiten, Stadt, Ruhr - Universitaet, Beratung, Geschlechtskranken, anonyme, Frauen, Frauen, Deutschland, Frauen, Kondome, Kondome, Frauen, Frauen, Gesundheitsbewusstsein, Risikobereitschaft, Frauen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .	[ "Regelmaessige", "Untersuchungen", "von", "Prostituierten", "sind", "eine", "Moeglichkeit", "der", "Praevention", "von", "sexuell", "uebertragbaren", "Krankheiten", "(", "STD", ")", "in", "dieser", "Risikogruppe", ".", "Seit", "dem", "1.4.1988", "wird", "im", "Gesundheitsamt", "der", "Stadt", "Bochum", "in", "Kooperation", "mit", "der", "Dermatologischen", "Klinik", "der", "Ruhr", "-", "Universitaet", "Bochum", "eine", "Sprechstunde", "zur", "Beratung", "und", "Untersuchung", "von", "Geschlechtskranken", "angeboten", ".", "Ziel", "der", "vorliegenden", "Studie", "war", "es", ",", "die", "Effektivitaet", "und", "Akzeptanz", "dieser", "Einrichtung", "zu", "ueberpruefen", ".", "Aus", "diesem", "Grund", "wurden", "anonyme", "Frageboegen", "ausgelegt", ",", "die", "von", "80", "Frauen", "beantwortet", "wurden", ".", "Der", "Altersdurchschnitt", "lag", "bei", "31,4", "Jahren", ".", "67", "Frauen", "stammten", "aus", "Deutschland", ".", "78", "der", "80", "Frauen", "benutzten", "immer", "Kondome", ",", "71", "glaubten", "an", "einen", "Gesundheitsschutz", "durch", "Kondome", ".", "3", "der", "80", "Frauen", "gaben", "an", ",", "in", "den", "letzten", "12", "Monaten", "an", "einer", "STD", "erkrankt", "zu", "sein", ".", "75", "der", "80", "Frauen", "empfanden", "die", "Untersuchung", "ausdruecklich", "nicht", "als", "diskriminierend", ";", "71", "beurteilten", "die", "Qualitaet", "der", "Untersuchungen", "als", "gut", ".", "Aus", "diesen", "Ergebnissen", "laesst", "sich", "ableiten", ",", "dass", "die", "von", "Dermatologen", "im", "Gesundheitsamt", "durchgefuehrten", "regelmaessigen", ",", "obligatorischen", "Untersuchungen", "zu", "einem", "hohen", "Gesundheitsbewusstsein", "mit", "geringer", "Risikobereitschaft", "gefuehrt", "haben", "und", "von", "den", "Frauen", "gut", "akzeptiert", "werden", "." ]	[ "umlsterm" ]
sexuell uebertragbaren Krankheiten, Stadt, Ruhr - Universitaet, Beratung, Geschlechtskranken, anonyme, Frauen, Frauen, Deutschland, Frauen, Kondome, Kondome, Frauen, Frauen, Gesundheitsbewusstsein, Risikobereitschaft, Frauen	DerHautarzt.70480166.ger.abstr_task2	Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .	[ "Regelmaessige", "Untersuchungen", "von", "Prostituierten", "sind", "eine", "Moeglichkeit", "der", "Praevention", "von", "sexuell", "uebertragbaren", "Krankheiten", "(", "STD", ")", "in", "dieser", "Risikogruppe", ".", "Seit", "dem", "1.4.1988", "wird", "im", "Gesundheitsamt", "der", "Stadt", "Bochum", "in", "Kooperation", "mit", "der", "Dermatologischen", "Klinik", "der", "Ruhr", "-", "Universitaet", "Bochum", "eine", "Sprechstunde", "zur", "Beratung", "und", "Untersuchung", "von", "Geschlechtskranken", "angeboten", ".", "Ziel", "der", "vorliegenden", "Studie", "war", "es", ",", "die", "Effektivitaet", "und", "Akzeptanz", "dieser", "Einrichtung", "zu", "ueberpruefen", ".", "Aus", "diesem", "Grund", "wurden", "anonyme", "Frageboegen", "ausgelegt", ",", "die", "von", "80", "Frauen", "beantwortet", "wurden", ".", "Der", "Altersdurchschnitt", "lag", "bei", "31,4", "Jahren", ".", "67", "Frauen", "stammten", "aus", "Deutschland", ".", "78", "der", "80", "Frauen", "benutzten", "immer", "Kondome", ",", "71", "glaubten", "an", "einen", "Gesundheitsschutz", "durch", "Kondome", ".", "3", "der", "80", "Frauen", "gaben", "an", ",", "in", "den", "letzten", "12", "Monaten", "an", "einer", "STD", "erkrankt", "zu", "sein", ".", "75", "der", "80", "Frauen", "empfanden", "die", "Untersuchung", "ausdruecklich", "nicht", "als", "diskriminierend", ";", "71", "beurteilten", "die", "Qualitaet", "der", "Untersuchungen", "als", "gut", ".", "Aus", "diesen", "Ergebnissen", "laesst", "sich", "ableiten", ",", "dass", "die", "von", "Dermatologen", "im", "Gesundheitsamt", "durchgefuehrten", "regelmaessigen", ",", "obligatorischen", "Untersuchungen", "zu", "einem", "hohen", "Gesundheitsbewusstsein", "mit", "geringer", "Risikobereitschaft", "gefuehrt", "haben", "und", "von", "den", "Frauen", "gut", "akzeptiert", "werden", "." ]	[ "umlsterm" ]
Thrombozytenwerte is an umlsterm, weisser is an umlsterm, Heparin - induzierter is an umlsterm, Thrombozytopenie is an umlsterm, Heparin - induzierten is an umlsterm, Heparin - Therapie is an umlsterm, Phenprocoumon is an umlsterm, Revisionseingriffs is an umlsterm, Hirudin is an umlsterm, Diagnosestellung is an umlsterm, Therapie is an umlsterm	Gefaesschirurgie.00050125.ger.abstr_task0	Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .	[ "Zusammenfassung", "Es", "wird", "ueber", "den", "Verlauf", "bei", "einer", "71jaehrigen", "Patientin", "berichtet", ",", "bei", "der", "es", "nach", "Anlage", "eines", "femoropoplitealen", "Bypasses", "sowie", "mehrfachen", "Revisions", "-", "operationen", "zu", "fruehen", "Bypassverschluessen", "und", "peripheren", "Gefaessokklusionen", "kam", ".", "Ein", "zusaetzli-", "cher", "Abfall", "der", "Thrombozytenwerte", "unter", "50", "%", "der", "Ausgangswerte", "in", "Zusammenhang", "mit", "dem", "intraoperativem", "Befund", "\"", "weisser", "Thromben", "\"", "lenkte", "den", "Verdacht", "auf", "ein", "White", "-", "clot", "-", "Syndrom", "'", "bei", "Heparin", "-", "induzierter", "Thrombozytopenie", "Typ", "II", ",", "welche", "sich", "im", "Heparin", "-", "induzierten", "Plaettchenaggregationstest", "(", "HIPA", ")", "bestaetigte", ".", "Nach", "Umsetzen", "der", "Heparin", "-", "Therapie", "auf", "Danaparoid", "-", "Na", "(", "Orgaran", ")", "kam", "es", "zu", "einem", "weiteren", "Abfall", "derThrombozyten", ".", "Der", "klini", "-", "sche", "Verdacht", "auf", "Kreuzreaktivitaet", "zu", "Danaparoid", "-", "Na", "wurde", "im", "HIPA", "-", "Test", "verifiziert", ".", "Im", "weiterem", "Verlauf", "erfolgte", "zunaechst", "die", "Antikoagula-", "tion", "mit", "Phenprocoumon", "(", "Marcumar", ")", "und", "dann", "im", "Rahmen", "eines", "Revisionseingriffs", "mit", "rekombinantem", "Hirudin", "(", "Refludan", ",", "Fa", ".", "Hoechst", ")", ".", "Die", "Probleme", "bezueglich", "rechtzeitiger", "Diagnosestellung", "und", "antikoagu", "-", "lativer", "Therapie", "bei", "Kreuzreaktivitaet", "mit", "Orgaran", "werden", "diskutiert", "." ]	[ "umlsterm" ]
Thrombozytenwerte is an umlsterm, weisser is an umlsterm, Heparin - induzierter is an umlsterm, Thrombozytopenie is an umlsterm, Heparin - induzierten is an umlsterm, Heparin - Therapie is an umlsterm, Phenprocoumon is an umlsterm, Revisionseingriffs is an umlsterm, Hirudin is an umlsterm, Diagnosestellung is an umlsterm, Therapie is an umlsterm	Gefaesschirurgie.00050125.ger.abstr_task1	Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please typing these entity words according to sentence: Thrombozytenwerte, weisser, Heparin - induzierter, Thrombozytopenie, Heparin - induzierten, Heparin - Therapie, Phenprocoumon, Revisionseingriffs, Hirudin, Diagnosestellung, Therapie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .	[ "Zusammenfassung", "Es", "wird", "ueber", "den", "Verlauf", "bei", "einer", "71jaehrigen", "Patientin", "berichtet", ",", "bei", "der", "es", "nach", "Anlage", "eines", "femoropoplitealen", "Bypasses", "sowie", "mehrfachen", "Revisions", "-", "operationen", "zu", "fruehen", "Bypassverschluessen", "und", "peripheren", "Gefaessokklusionen", "kam", ".", "Ein", "zusaetzli-", "cher", "Abfall", "der", "Thrombozytenwerte", "unter", "50", "%", "der", "Ausgangswerte", "in", "Zusammenhang", "mit", "dem", "intraoperativem", "Befund", "\"", "weisser", "Thromben", "\"", "lenkte", "den", "Verdacht", "auf", "ein", "White", "-", "clot", "-", "Syndrom", "'", "bei", "Heparin", "-", "induzierter", "Thrombozytopenie", "Typ", "II", ",", "welche", "sich", "im", "Heparin", "-", "induzierten", "Plaettchenaggregationstest", "(", "HIPA", ")", "bestaetigte", ".", "Nach", "Umsetzen", "der", "Heparin", "-", "Therapie", "auf", "Danaparoid", "-", "Na", "(", "Orgaran", ")", "kam", "es", "zu", "einem", "weiteren", "Abfall", "derThrombozyten", ".", "Der", "klini", "-", "sche", "Verdacht", "auf", "Kreuzreaktivitaet", "zu", "Danaparoid", "-", "Na", "wurde", "im", "HIPA", "-", "Test", "verifiziert", ".", "Im", "weiterem", "Verlauf", "erfolgte", "zunaechst", "die", "Antikoagula-", "tion", "mit", "Phenprocoumon", "(", "Marcumar", ")", "und", "dann", "im", "Rahmen", "eines", "Revisionseingriffs", "mit", "rekombinantem", "Hirudin", "(", "Refludan", ",", "Fa", ".", "Hoechst", ")", ".", "Die", "Probleme", "bezueglich", "rechtzeitiger", "Diagnosestellung", "und", "antikoagu", "-", "lativer", "Therapie", "bei", "Kreuzreaktivitaet", "mit", "Orgaran", "werden", "diskutiert", "." ]	[ "umlsterm" ]
Thrombozytenwerte, weisser, Heparin - induzierter, Thrombozytopenie, Heparin - induzierten, Heparin - Therapie, Phenprocoumon, Revisionseingriffs, Hirudin, Diagnosestellung, Therapie	Gefaesschirurgie.00050125.ger.abstr_task2	Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .	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Venensystems is an umlsterm, Diagnostik is an umlsterm, Therapiekontrolle is an umlsterm, Kompressionssonographie is an umlsterm, Diagnostik is an umlsterm, tiefen Venenthrombose is an umlsterm, Thrombosen is an umlsterm, Syndrom is an umlsterm, Phlebographie is an umlsterm, Venenerkrankungen is an umlsterm, Halses is an umlsterm, Arme is an umlsterm, Beine is an umlsterm, Patienten is an umlsterm, Intensivstationen is an umlsterm, Beurteilung is an umlsterm, Dialyseshunts is an umlsterm, Diagnostik is an umlsterm, Ultraschalluntersuchungen is an umlsterm, Venenerkrankungen is an umlsterm	DerRadiologe.80380560.ger.abstr_task0	Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .	[ "Die", "Haeufigkeit", "akuter", "und", "chronischer", "Erkrankungen", "des", "Venensystems", "erfordert", "fuer", "die", "Diagnostik", "und", "Therapiekontrolle", "zuverlaessige", "nichtinvasive", "und", "moeglichst", "kostenguenstige", "Untersuchungsverfahren", ".", ",", "Bereits", "Mitte", "der", "80er", "Jahre", "hat", "sich", "die", "Kompressionssonographie", "als", "wertvolle", "Bereicherung", "bei", "der", "Diagnostik", "der", "tiefen", "Venenthrombose", "etabliert", ".", "Dopplersonographische", "Untersuchungsmethoden", "haben", "insbesondere", "seit", "Einfuehrung", "der", "Farbduplexsonographie", "einen", "hohen", "Stellenwert", "erreicht", ".", "Bei", "Thrombosen", ",", "beim", "postthrombotischen", "Syndrom", "und", "bei", "der", "primaeren", "Varikosis", "verdraengt", "die", "Farbduplexsonographie", "zunehmend", "die", "Phlebographie", ".", "Venenerkrankungen", "des", "Halses", ",", "der", "Arme", "und", "Beine", "koennen", "heute", "mittels", "Farbduplexsonographie", "zuverlaessig", "erkannt", "werden", ".", "Neuere", "Einsatzgebiete", "fuer", "die", "Duplex-", "bzw", ".", "Farbduplexsonographie", "schliessen", "das", "venoese", "Gefaesssystem", "bei", "Patienten", "auf", "Intensivstationen", ",", "die", "Beurteilung", "von", "transplantierten", "Organen", "und", "die", "Darstellung", "der", "Stroemungsverhaeltnisse", "in", "Dialyseshunts", "ein", ".", "Angesichts", "der", "Kostenentwicklung", "bei", "der", "bildgebenden", "Diagnostik", ",", "an", "der", "die", "drastische", "Zunahme", "der", "Ultraschalluntersuchungen", "einen", "grossen", "Anteil", "hat", ",", "ist", "allerdings", "eine", "kritische", "Indikationsstellung", "zum", "Einsatz", "der", "Doppler-", "und", "Duplexsonographieverfahren", "auch", "bei", "der", "Untersuchung", "von", "Venenerkrankungen", "zu", "fordern", "." ]	[ "umlsterm" ]
Venensystems is an umlsterm, Diagnostik is an umlsterm, Therapiekontrolle is an umlsterm, Kompressionssonographie is an umlsterm, Diagnostik is an umlsterm, tiefen Venenthrombose is an umlsterm, Thrombosen is an umlsterm, Syndrom is an umlsterm, Phlebographie is an umlsterm, Venenerkrankungen is an umlsterm, Halses is an umlsterm, Arme is an umlsterm, Beine is an umlsterm, Patienten is an umlsterm, Intensivstationen is an umlsterm, Beurteilung is an umlsterm, Dialyseshunts is an umlsterm, Diagnostik is an umlsterm, Ultraschalluntersuchungen is an umlsterm, Venenerkrankungen is an umlsterm	DerRadiologe.80380560.ger.abstr_task1	Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please typing these entity words according to sentence: Venensystems, Diagnostik, Therapiekontrolle, Kompressionssonographie, Diagnostik, tiefen Venenthrombose, Thrombosen, Syndrom, Phlebographie, Venenerkrankungen, Halses, Arme, Beine, Patienten, Intensivstationen, Beurteilung, Dialyseshunts, Diagnostik, Ultraschalluntersuchungen, Venenerkrankungen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .	[ "Die", "Haeufigkeit", "akuter", "und", "chronischer", "Erkrankungen", "des", "Venensystems", "erfordert", "fuer", "die", "Diagnostik", "und", "Therapiekontrolle", "zuverlaessige", "nichtinvasive", "und", "moeglichst", "kostenguenstige", "Untersuchungsverfahren", ".", ",", "Bereits", "Mitte", "der", "80er", "Jahre", "hat", "sich", "die", "Kompressionssonographie", "als", "wertvolle", "Bereicherung", "bei", "der", "Diagnostik", "der", "tiefen", "Venenthrombose", "etabliert", ".", "Dopplersonographische", "Untersuchungsmethoden", "haben", "insbesondere", "seit", "Einfuehrung", "der", "Farbduplexsonographie", "einen", "hohen", "Stellenwert", "erreicht", ".", "Bei", "Thrombosen", ",", "beim", "postthrombotischen", "Syndrom", "und", "bei", "der", "primaeren", "Varikosis", "verdraengt", "die", "Farbduplexsonographie", "zunehmend", "die", "Phlebographie", ".", "Venenerkrankungen", "des", "Halses", ",", "der", "Arme", "und", "Beine", "koennen", "heute", "mittels", "Farbduplexsonographie", "zuverlaessig", "erkannt", "werden", ".", "Neuere", "Einsatzgebiete", "fuer", "die", "Duplex-", "bzw", ".", "Farbduplexsonographie", "schliessen", "das", "venoese", "Gefaesssystem", "bei", "Patienten", "auf", "Intensivstationen", ",", "die", "Beurteilung", "von", "transplantierten", "Organen", "und", "die", "Darstellung", "der", "Stroemungsverhaeltnisse", "in", "Dialyseshunts", "ein", ".", "Angesichts", "der", "Kostenentwicklung", "bei", "der", "bildgebenden", "Diagnostik", ",", "an", "der", "die", "drastische", "Zunahme", "der", "Ultraschalluntersuchungen", "einen", "grossen", "Anteil", "hat", ",", "ist", "allerdings", "eine", "kritische", "Indikationsstellung", "zum", "Einsatz", "der", "Doppler-", "und", "Duplexsonographieverfahren", "auch", "bei", "der", "Untersuchung", "von", "Venenerkrankungen", "zu", "fordern", "." ]	[ "umlsterm" ]
Venensystems, Diagnostik, Therapiekontrolle, Kompressionssonographie, Diagnostik, tiefen Venenthrombose, Thrombosen, Syndrom, Phlebographie, Venenerkrankungen, Halses, Arme, Beine, Patienten, Intensivstationen, Beurteilung, Dialyseshunts, Diagnostik, Ultraschalluntersuchungen, Venenerkrankungen	DerRadiologe.80380560.ger.abstr_task2	Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .	[ "Die", "Haeufigkeit", "akuter", "und", "chronischer", "Erkrankungen", "des", "Venensystems", "erfordert", "fuer", "die", "Diagnostik", "und", "Therapiekontrolle", "zuverlaessige", "nichtinvasive", "und", "moeglichst", "kostenguenstige", "Untersuchungsverfahren", ".", ",", "Bereits", "Mitte", "der", "80er", "Jahre", "hat", "sich", "die", "Kompressionssonographie", "als", "wertvolle", "Bereicherung", "bei", "der", "Diagnostik", "der", "tiefen", "Venenthrombose", "etabliert", ".", "Dopplersonographische", "Untersuchungsmethoden", "haben", "insbesondere", "seit", "Einfuehrung", "der", "Farbduplexsonographie", "einen", "hohen", "Stellenwert", "erreicht", ".", "Bei", "Thrombosen", ",", "beim", "postthrombotischen", "Syndrom", "und", "bei", "der", "primaeren", "Varikosis", "verdraengt", "die", "Farbduplexsonographie", "zunehmend", "die", "Phlebographie", ".", "Venenerkrankungen", "des", "Halses", ",", "der", "Arme", "und", "Beine", "koennen", "heute", "mittels", "Farbduplexsonographie", "zuverlaessig", "erkannt", "werden", ".", "Neuere", "Einsatzgebiete", "fuer", "die", "Duplex-", "bzw", ".", "Farbduplexsonographie", "schliessen", "das", "venoese", "Gefaesssystem", "bei", "Patienten", "auf", "Intensivstationen", ",", "die", "Beurteilung", "von", "transplantierten", "Organen", "und", "die", "Darstellung", "der", "Stroemungsverhaeltnisse", "in", "Dialyseshunts", "ein", ".", "Angesichts", "der", "Kostenentwicklung", "bei", "der", "bildgebenden", "Diagnostik", ",", "an", "der", "die", "drastische", "Zunahme", "der", "Ultraschalluntersuchungen", "einen", "grossen", "Anteil", "hat", ",", "ist", "allerdings", "eine", "kritische", "Indikationsstellung", "zum", "Einsatz", "der", "Doppler-", "und", "Duplexsonographieverfahren", "auch", "bei", "der", "Untersuchung", "von", "Venenerkrankungen", "zu", "fordern", "." ]	[ "umlsterm" ]
Bacterial peptidoglycan is a carbohydrate, CD14-dependent activation is an other_name, transcription factors is a protein_family_or_group, CREB / ATF is a protein_molecule, AP-1 is a protein_molecule	38927_task0	Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: carbohydrate, protein_family_or_group, protein_molecule, other_name	[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]	Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.	[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]	[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]
Bacterial peptidoglycan is a carbohydrate, CD14-dependent activation is an other_name, transcription factors is a protein_family_or_group, CREB / ATF is a protein_molecule, AP-1 is a protein_molecule	38927_task1	Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please typing these entity words according to sentence: Bacterial peptidoglycan, CD14-dependent activation, transcription factors, CREB / ATF, AP-1 Options: carbohydrate, protein_family_or_group, protein_molecule, other_name	[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]	Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.	[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]	[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]
Bacterial peptidoglycan, CD14-dependent activation, transcription factors, CREB / ATF, AP-1	38927_task2	Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please extract entity words from the input sentence	[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]	Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.	[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]	[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]
melanoma is a Participant_Condition, behavioral intervention project is a Intervention_Educational, report is a Outcome_Other, individual and family - level factors is a Outcome_Mental, participation is a Outcome_Mental, web - based communication and support intervention is a Intervention_Educational, three family members per family is a Participant_Sample-size, 18 or younger is a Participant_Age, 1380 is a Participant_Sample-size, 313 is a Participant_Sample-size, refusal is a Outcome_Other, higher educational attainment . is a Outcome_Mental, diagnosed more recently is a Outcome_Physical, parent was partnered is a Outcome_Other, parent lived in the same city as the case is a Outcome_Mental	52244_task0	Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .	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melanoma is a Participant_Condition, behavioral intervention project is a Intervention_Educational, report is a Outcome_Other, individual and family - level factors is a Outcome_Mental, participation is a Outcome_Mental, web - based communication and support intervention is a Intervention_Educational, three family members per family is a Participant_Sample-size, 18 or younger is a Participant_Age, 1380 is a Participant_Sample-size, 313 is a Participant_Sample-size, refusal is a Outcome_Other, higher educational attainment . is a Outcome_Mental, diagnosed more recently is a Outcome_Physical, parent was partnered is a Outcome_Other, parent lived in the same city as the case is a Outcome_Mental	52244_task1	Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please typing these entity words according to sentence: melanoma, behavioral intervention project, report, individual and family - level factors, participation, web - based communication and support intervention, three family members per family, 18 or younger, 1380, 313, refusal, higher educational attainment ., diagnosed more recently, parent was partnered, parent lived in the same city as the case Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .	[ "Predictors", "of", "recruited", "melanoma", "families", "into", "a", "behavioral", "intervention", "project", ".", "BACKGROUND", "Examination", "of", "families", "represents", "an", "important", "priority", "in", "health", "research", ".", "In", "this", "paper", "we", "report", "on", "individual", "and", "family", "-", "level", "factors", "associated", "with", "enrollment", "in", "a", "cancer", "prevention", "research", "project", ".", "We", "approached", "families", "affected", "by", "melanoma", "for", "possible", "participation", "in", "a", "randomized", "controlled", "trial", "of", "a", "web", "-", "based", "communication", "and", "support", "intervention", ".", "METHODS", "We", "recruited", "three", "family", "members", "per", "family", "for", "assessment", "-", "the", "melanoma", "case", ",", "a", "first", "-", "degree", "relative", "(", "FDR", ")", ",", "and", "a", "relative", "who", "is", "a", "parent", "of", "a", "child", "age", "18", "or", "younger", ".", "Recruitment", "involved", "three", "steps", ":", "requesting", "the", "physician", "'", "s", "consent", "to", "approach", "the", "melanoma", "case", ",", "approaching", "the", "case", "to", "request", "their", "participation", "and", "family", "contact", "information", ",", "and", "they", "approaching", "the", "FDRs", "and", "parents", ".", "RESULTS", "Of", "the", "1380", "families", "approached", ",", "313", "were", "enrolled", ",", "263", "were", "excluded", "because", "we", "could", "not", "find", "or", "contact", "a", "family", "member", "(", "FDR", "or", "parent", ")", ",", "331", "did", "not", "have", "eligible", "family", "members", ",", "and", "473", "refused", ".", "The", "most", "frequently", "noted", "reason", "for", "refusal", "was", "being", "too", "busy", "or", "having", "no", "time", ".", "The", "primary", "predictors", "of", "participation", "for", "cases", "(", "OR=1.6", ";", "CI=1.01", "-", "2.51", ")", "and", "FDRs", "(", "OR=2.15", ";", "CI=1.11", "-", "4.13", ")", "included", "higher", "educational", "attainment", ".", "FDRs", "were", "more", "likely", "to", "enroll", "if", "they", "were", "female", "(", "OR=1.77", ";", "CI=1.1-.85", ")", "and", "parents", "were", "more", "likely", "to", "enroll", "if", "the", "case", "had", "been", "diagnosed", "more", "recently", "(", "OR=3.3", ";", "CI=1.9", "-", "5.93", ")", ",", "if", "the", "parent", "was", "partnered", "(", "OR=4.37", ";", "CI=1.86", "-", "10.26", ")", ",", "and", "if", "the", "parent", "lived", "in", "the", "same", "city", "as", "the", "case", "(", "OR=2.88", ";", "CI=1.08", "-", "7.68", ")", ".", "CONCLUSIONS", "The", "results", "can", "provide", "information", "on", "potential", "directions", "for", "future", "family", "recruitment", "." ]	[ "Intervention_Educational", "Outcome_Mental", "Participant_Sample-size", "Outcome_Physical", "Outcome_Other", "Participant_Age", "Participant_Condition" ]
melanoma, behavioral intervention project, report, individual and family - level factors, participation, web - based communication and support intervention, three family members per family, 18 or younger, 1380, 313, refusal, higher educational attainment ., diagnosed more recently, parent was partnered, parent lived in the same city as the case	52244_task2	Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .	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Pregnant is a Condition, American Society of Anesthesiologists risk classification is a Measurement, I and II is a Value, Age is a Person, > 18 years is a Value, Non - laboring is a Value, elective is a Qualifier, cesarean sections is a Procedure	NCT02872935_inc_task0	Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Procedure, Measurement	[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]	Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections	[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]	[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]
Pregnant is a Condition, American Society of Anesthesiologists risk classification is a Measurement, I and II is a Value, Age is a Person, > 18 years is a Value, Non - laboring is a Value, elective is a Qualifier, cesarean sections is a Procedure	NCT02872935_inc_task1	Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please typing these entity words according to sentence: Pregnant, American Society of Anesthesiologists risk classification, I and II, Age, > 18 years, Non - laboring, elective, cesarean sections Options: Condition, Qualifier, Value, Person, Procedure, Measurement	[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]	Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections	[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]	[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]
Pregnant, American Society of Anesthesiologists risk classification, I and II, Age, > 18 years, Non - laboring, elective, cesarean sections	NCT02872935_inc_task2	Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please extract entity words from the input sentence	[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]	Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections	[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]	[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]
digoxin is a DRUG, amiodarone is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, amiodarone is a DRUG, digoxin is a DRUG, Digoxin is a DRUG, Digoxin is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, digoxin is a DRUG	3964797_task0	Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DRUG	[ "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.	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digoxin is a DRUG, amiodarone is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, amiodarone is a DRUG, digoxin is a DRUG, Digoxin is a DRUG, Digoxin is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, digoxin is a DRUG	3964797_task1	Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please typing these entity words according to sentence: digoxin, amiodarone, Amiodarone, digoxin, digoxin, digoxin, amiodarone, amiodarone, digoxin, Digoxin, Digoxin, Amiodarone, digoxin, digoxin, amiodarone, digoxin Options: DRUG	[ "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.	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digoxin, amiodarone, Amiodarone, digoxin, digoxin, digoxin, amiodarone, amiodarone, digoxin, Digoxin, Digoxin, Amiodarone, digoxin, digoxin, amiodarone, digoxin	3964797_task2	Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.	[ "Pharmacokinetic", "evaluation", "of", "the", "digoxin", "-", "amiodarone", "interaction", ".", "Amiodarone", "is", "known", "to", "raise", "serum", "digoxin", "levels", ".", "This", "study", "was", "designed", "to", "evaluate", "the", "pharmacokinetic", "basis", "of", "this", "interaction", "in", "10", "normal", "subjects", ".", "The", "pharmacokinetic", "variables", "for", "digoxin", "were", "determined", "after", "a", "1.0", "mg", "intravenous", "dose", "of", "digoxin", "in", "each", "subject", ",", "before", "and", "after", "oral", "amiodarone", ",", "400", "mg", "daily", "for", "3", "weeks", ".", "During", "amiodarone", "administration", ",", "systemic", "clearance", "of", "digoxin", "was", "reduced", "from", "234", "+", "/-", "72", "ml", "/", "min", "(", "mean", "+", "/-", "standard", "deviation", ")", "to", "172", "+", "/-", "33", "ml", "/", "min", "(", "p", "less", "than", "0.01", ")", ".", "This", "was", "due", "to", "reductions", "in", "both", "renal", "clearance", "(", "from", "105", "+", "/-", "39", "to", "84", "+", "/-", "15", "ml", "/", "min", ")", "(", "p", "less", "than", "0.05", ")", "and", "nonrenal", "clearance", "(", "from", "130", "+", "/-", "38", "to", "88", "+", "/-", "20", "ml", "/", "min", ")", "(", "p", "less", "than", "0.01", ")", ".", "Digoxin", "half", "-", "life", "of", "elimination", "was", "prolonged", "from", "34", "+", "/-", "13", "to", "40", "+", "/-", "16", "hours", "(", "p", "less", "than", "0.05", ")", ".", "Digoxin", "volume", "of", "distribution", "was", "not", "significantly", "changed", ".", "Amiodarone", "caused", "a", "three-", "to", "fivefold", "increase", "in", "serum", "reverse", "triiodothyronine", "levels", ",", "but", "changes", "in", "thyroid", "function", "were", "not", "quantitatively", "related", "to", "the", "changes", "in", "digoxin", "pharmacokinetics", ".", "These", "alterations", "in", "digoxin", "pharmacokinetics", "produced", "by", "amiodarone", "explain", "the", "increase", "in", "serum", "digoxin", "level", "that", "has", "been", "observed", "when", "this", "drug", "combination", "has", "been", "used", "clinically", "." ]	[ "DRUG" ]
Patienten is an umlsterm, Patientengut is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Schmerzmittel is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Selbst is an umlsterm	DerChirurg.70680613.ger.abstr_task0	Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .	[ "Zusammenfassung", ".", "In", "einer", "prospektiven", "Beobachtungsstudie", "wurden", "140", "Patienten", "erfasst", ",", "die", "rein", "ambulant", "laparoskopisch", "cholecystektomiert", "wurden", ".", "Das", "Patientengut", "entspricht", "im", "wesentlichen", "den", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Es", "gab", "keine", "relevanten", "intra-", "und", "postoperativen", "Komplikationen", ".", "Postoperativ", "brauchten", "die", "Patienten", "weniger", "Schmerzmittel", ",", "erholten", "sich", "schneller", "und", "waren", "schneller", "wieder", "arbeitsfaehig", "als", "Patienten", "in", "vergleichbaren", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Die", "ambulante", "laparoskopische", "Cholecystektomie", "ist", "eine", "gute", "Alternative", "fuer", "Patienten", "mit", "geringem", "oder", "mittlerem", "Risiko", ".", "Selbst", "bei", "verbesserter", "Ertragssituation", "fuer", "die", "Operationseinrichtung", "eroeffnet", "sie", "ausserdem", "Einsparpotentiale", "im", "Gesundheitssystem", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Patientengut is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Schmerzmittel is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Selbst is an umlsterm	DerChirurg.70680613.ger.abstr_task1	Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please typing these entity words according to sentence: Patienten, Patientengut, Patienten, Komplikationen, Patienten, Schmerzmittel, Patienten, Patienten, Patienten, Risiko, Selbst Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .	[ "Zusammenfassung", ".", "In", "einer", "prospektiven", "Beobachtungsstudie", "wurden", "140", "Patienten", "erfasst", ",", "die", "rein", "ambulant", "laparoskopisch", "cholecystektomiert", "wurden", ".", "Das", "Patientengut", "entspricht", "im", "wesentlichen", "den", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Es", "gab", "keine", "relevanten", "intra-", "und", "postoperativen", "Komplikationen", ".", "Postoperativ", "brauchten", "die", "Patienten", "weniger", "Schmerzmittel", ",", "erholten", "sich", "schneller", "und", "waren", "schneller", "wieder", "arbeitsfaehig", "als", "Patienten", "in", "vergleichbaren", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Die", "ambulante", "laparoskopische", "Cholecystektomie", "ist", "eine", "gute", "Alternative", "fuer", "Patienten", "mit", "geringem", "oder", "mittlerem", "Risiko", ".", "Selbst", "bei", "verbesserter", "Ertragssituation", "fuer", "die", "Operationseinrichtung", "eroeffnet", "sie", "ausserdem", "Einsparpotentiale", "im", "Gesundheitssystem", "." ]	[ "umlsterm" ]
Patienten, Patientengut, Patienten, Komplikationen, Patienten, Schmerzmittel, Patienten, Patienten, Patienten, Risiko, Selbst	DerChirurg.70680613.ger.abstr_task2	Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .	[ "Zusammenfassung", ".", "In", "einer", "prospektiven", "Beobachtungsstudie", "wurden", "140", "Patienten", "erfasst", ",", "die", "rein", "ambulant", "laparoskopisch", "cholecystektomiert", "wurden", ".", "Das", "Patientengut", "entspricht", "im", "wesentlichen", "den", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Es", "gab", "keine", "relevanten", "intra-", "und", "postoperativen", "Komplikationen", ".", "Postoperativ", "brauchten", "die", "Patienten", "weniger", "Schmerzmittel", ",", "erholten", "sich", "schneller", "und", "waren", "schneller", "wieder", "arbeitsfaehig", "als", "Patienten", "in", "vergleichbaren", "Veroeffentlichungen", "stationaer", "operierter", "Patienten", ".", "Die", "ambulante", "laparoskopische", "Cholecystektomie", "ist", "eine", "gute", "Alternative", "fuer", "Patienten", "mit", "geringem", "oder", "mittlerem", "Risiko", ".", "Selbst", "bei", "verbesserter", "Ertragssituation", "fuer", "die", "Operationseinrichtung", "eroeffnet", "sie", "ausserdem", "Einsparpotentiale", "im", "Gesundheitssystem", "." ]	[ "umlsterm" ]
saline solution load test is a Intervention_Educational, appropriate volume is a Outcome_Other, needle location is a Outcome_Other, Fifty - six is a Participant_Sample-size, patients is a Participant_Sample-size, scheduled for knee arthroscopy is a Participant_Condition, single stab incision with use of a number-11 blade is a Intervention_Physical, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle is a Intervention_Pharmacological, thirty - one is a Participant_Sample-size, female is a Participant_Sex, patients and twenty - five is a Participant_Sample-size, average age of fifty years is a Participant_Age, average body mass index is a Outcome_Physical, diagnose 50 % of the arthrotomies is a Outcome_Other, volumes that were needed in order to effectively diagnose is a Outcome_Other, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations is a Outcome_Physical, significantly less fluid is a Outcome_Other	38515_task0	Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Sex", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .	[ "Detection", "of", "traumatic", "arthrotomy", "of", "the", "knee", "using", "the", "saline", "solution", "load", "test", ".", "BACKGROUND", "The", "saline", "solution", "load", "test", "helps", "to", "determine", "if", "a", "wound", "extends", "into", "the", "knee", "joint", ".", "Little", "is", "known", "about", "the", "volume", "of", "injected", "intra", "-", "articular", "saline", "solution", "that", "is", "needed", "to", "effectively", "rule", "in", "or", "rule", "out", "a", "traumatic", "arthrotomy", "of", "the", "knee", ".", "The", "purpose", "of", "the", "present", "study", "was", "to", "determine", "the", "appropriate", "volume", "and", "needle", "location", "for", "the", "diagnosis", "of", "a", "traumatic", "knee", "arthrotomy", "and", "to", "assess", "the", "effect", "of", "associated", "variables", ",", "including", "knee", "circumference", ",", "body", "mass", "index", ",", "and", "sex", ".", "METHODS", "Fifty", "-", "six", "consecutive", "patients", "scheduled", "for", "knee", "arthroscopy", "were", "enrolled", ".", "A", "standard", "inferolateral", "arthroscopic", "portal", "was", "made", "with", "a", "single", "stab", "incision", "with", "use", "of", "a", "number-11", "blade", ".", "Injection", "sites", "were", "randomized", "to", "either", "a", "superomedial", "or", "inferomedial", "location", ".", "The", "injection", "of", "normal", "saline", "solution", "at", "a", "rate", "of", "5", "mL", "/", "sec", "through", "an", "18-gauge", "needle", "was", "continued", "while", "the", "knee", "was", "moved", "through", "a", "range", "of", "motion", "until", "fluid", "extravasated", "from", "the", "iatrogenic", "laceration", ".", "The", "volume", "of", "injected", "fluid", "was", "recorded", ".", "RESULTS", "The", "study", "group", "included", "thirty", "-", "one", "female", "patients", "and", "twenty", "-", "five", "male", "patients", "with", "a", "combined", "average", "age", "of", "fifty", "years", "and", "an", "average", "body", "mass", "index", "of", "30.9", ".", "In", "order", "to", "effectively", "diagnose", "50", "%", "of", "the", "arthrotomies", ",", "75", "mL", "of", "injected", "fluid", "was", "needed", ";", "the", "volumes", "that", "were", "needed", "in", "order", "to", "effectively", "diagnose", "75", "%", ",", "90", "%", ",", "95", "%", ",", "and", "99", "%", "of", "the", "arthrotomies", "were", "110", ",", "145", ",", "155", ",", "and", "175", "mL", ",", "respectively", ".", "The", "mean", "volumes", "of", "injected", "fluid", "needed", "for", "a", "positive", "result", "at", "the", "inferomedial", "and", "superomedial", "needle", "locations", "were", "64.0", "and", "95.2", "mL", ",", "respectively", ";", "this", "difference", "was", "significant", "(", "p", "=", "0.01", ")", ".", "There", "was", "no", "correlation", "between", "necessary", "injection", "volume", "and", "sex", ",", "body", "mass", "index", ",", "or", "knee", "circumference", ".", "CONCLUSIONS", "In", "order", "to", "detect", "95", "%", "of", "1-cm", "inferolateral", "arthrotomies", "of", "the", "knee", "with", "use", "of", "the", "saline", "solution", "load", "test", ",", "155", "mL", "must", "be", "injected", ".", "An", "inferomedial", "injection", "location", "requires", "significantly", "less", "fluid", "than", "a", "superomedial", "injection", "location", "does", "for", "the", "diagnosis", "of", "inferolateral", "arthrotomies", "of", "the", "knee", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Physical", "Participant_Condition", "Participant_Age", "Intervention_Educational", "Participant_Sample-size", "Participant_Sex" ]
saline solution load test is a Intervention_Educational, appropriate volume is a Outcome_Other, needle location is a Outcome_Other, Fifty - six is a Participant_Sample-size, patients is a Participant_Sample-size, scheduled for knee arthroscopy is a Participant_Condition, single stab incision with use of a number-11 blade is a Intervention_Physical, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle is a Intervention_Pharmacological, thirty - one is a Participant_Sample-size, female is a Participant_Sex, patients and twenty - five is a Participant_Sample-size, average age of fifty years is a Participant_Age, average body mass index is a Outcome_Physical, diagnose 50 % of the arthrotomies is a Outcome_Other, volumes that were needed in order to effectively diagnose is a Outcome_Other, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations is a Outcome_Physical, significantly less fluid is a Outcome_Other	38515_task1	Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please typing these entity words according to sentence: saline solution load test, appropriate volume, needle location, Fifty - six, patients, scheduled for knee arthroscopy, single stab incision with use of a number-11 blade, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle, thirty - one, female, patients and twenty - five, average age of fifty years, average body mass index, diagnose 50 % of the arthrotomies, volumes that were needed in order to effectively diagnose, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations, significantly less fluid Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Sex", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .	[ "Detection", "of", "traumatic", "arthrotomy", "of", "the", "knee", "using", "the", "saline", "solution", "load", "test", ".", "BACKGROUND", "The", "saline", "solution", "load", "test", "helps", "to", "determine", "if", "a", "wound", "extends", "into", "the", "knee", "joint", ".", "Little", "is", "known", "about", "the", "volume", "of", "injected", "intra", "-", "articular", "saline", "solution", "that", "is", "needed", "to", "effectively", "rule", "in", "or", "rule", "out", "a", "traumatic", "arthrotomy", "of", "the", "knee", ".", "The", "purpose", "of", "the", "present", "study", "was", "to", "determine", "the", "appropriate", "volume", "and", "needle", "location", "for", "the", "diagnosis", "of", "a", "traumatic", "knee", "arthrotomy", "and", "to", "assess", "the", "effect", "of", "associated", "variables", ",", "including", "knee", "circumference", ",", "body", "mass", "index", ",", "and", "sex", ".", "METHODS", "Fifty", "-", "six", "consecutive", "patients", "scheduled", "for", "knee", "arthroscopy", "were", "enrolled", ".", "A", "standard", "inferolateral", "arthroscopic", "portal", "was", "made", "with", "a", "single", "stab", "incision", "with", "use", "of", "a", "number-11", "blade", ".", "Injection", "sites", "were", "randomized", "to", "either", "a", "superomedial", "or", "inferomedial", "location", ".", "The", "injection", "of", "normal", "saline", "solution", "at", "a", "rate", "of", "5", "mL", "/", "sec", "through", "an", "18-gauge", "needle", "was", "continued", "while", "the", "knee", "was", "moved", "through", "a", "range", "of", "motion", "until", "fluid", "extravasated", "from", "the", "iatrogenic", "laceration", ".", "The", "volume", "of", "injected", "fluid", "was", "recorded", ".", "RESULTS", "The", "study", "group", "included", "thirty", "-", "one", "female", "patients", "and", "twenty", "-", "five", "male", "patients", "with", "a", "combined", "average", "age", "of", "fifty", "years", "and", "an", "average", "body", "mass", "index", "of", "30.9", ".", "In", "order", "to", "effectively", "diagnose", "50", "%", "of", "the", "arthrotomies", ",", "75", "mL", "of", "injected", "fluid", "was", "needed", ";", "the", "volumes", "that", "were", "needed", "in", "order", "to", "effectively", "diagnose", "75", "%", ",", "90", "%", ",", "95", "%", ",", "and", "99", "%", "of", "the", "arthrotomies", "were", "110", ",", "145", ",", "155", ",", "and", "175", "mL", ",", "respectively", ".", "The", "mean", "volumes", "of", "injected", "fluid", "needed", "for", "a", "positive", "result", "at", "the", "inferomedial", "and", "superomedial", "needle", "locations", "were", "64.0", "and", "95.2", "mL", ",", "respectively", ";", "this", "difference", "was", "significant", "(", "p", "=", "0.01", ")", ".", "There", "was", "no", "correlation", "between", "necessary", "injection", "volume", "and", "sex", ",", "body", "mass", "index", ",", "or", "knee", "circumference", ".", "CONCLUSIONS", "In", "order", "to", "detect", "95", "%", "of", "1-cm", "inferolateral", "arthrotomies", "of", "the", "knee", "with", "use", "of", "the", "saline", "solution", "load", "test", ",", "155", "mL", "must", "be", "injected", ".", "An", "inferomedial", "injection", "location", "requires", "significantly", "less", "fluid", "than", "a", "superomedial", "injection", "location", "does", "for", "the", "diagnosis", "of", "inferolateral", "arthrotomies", "of", "the", "knee", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Physical", "Participant_Condition", "Participant_Age", "Intervention_Educational", "Participant_Sample-size", "Participant_Sex" ]
saline solution load test, appropriate volume, needle location, Fifty - six, patients, scheduled for knee arthroscopy, single stab incision with use of a number-11 blade, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle, thirty - one, female, patients and twenty - five, average age of fifty years, average body mass index, diagnose 50 % of the arthrotomies, volumes that were needed in order to effectively diagnose, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations, significantly less fluid	38515_task2	Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Sex", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .	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Neubildungen is an umlsterm, Pleura is an umlsterm, Perikards is an umlsterm, Deutschland is an umlsterm, Asbestgefaehrdung is an umlsterm, Berufskrankheiten is an umlsterm, Aetiologie is an umlsterm, Standard is an umlsterm, Diagnostik is an umlsterm, Chirurgie is an umlsterm, chromosomale is an umlsterm, Tumorentstehung is an umlsterm, Diagnose is an umlsterm, gezielter is an umlsterm, Biopsieentnahme is an umlsterm, Chirurgie is an umlsterm, Diagnostik is an umlsterm, Tumoren is an umlsterm, Haeute is an umlsterm	DerChirurg.00710877.ger.abstr_task0	Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .	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Neubildungen is an umlsterm, Pleura is an umlsterm, Perikards is an umlsterm, Deutschland is an umlsterm, Asbestgefaehrdung is an umlsterm, Berufskrankheiten is an umlsterm, Aetiologie is an umlsterm, Standard is an umlsterm, Diagnostik is an umlsterm, Chirurgie is an umlsterm, chromosomale is an umlsterm, Tumorentstehung is an umlsterm, Diagnose is an umlsterm, gezielter is an umlsterm, Biopsieentnahme is an umlsterm, Chirurgie is an umlsterm, Diagnostik is an umlsterm, Tumoren is an umlsterm, Haeute is an umlsterm	DerChirurg.00710877.ger.abstr_task1	Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please typing these entity words according to sentence: Neubildungen, Pleura, Perikards, Deutschland, Asbestgefaehrdung, Berufskrankheiten, Aetiologie, Standard, Diagnostik, Chirurgie, chromosomale, Tumorentstehung, Diagnose, gezielter, Biopsieentnahme, Chirurgie, Diagnostik, Tumoren, Haeute Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .	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Neubildungen, Pleura, Perikards, Deutschland, Asbestgefaehrdung, Berufskrankheiten, Aetiologie, Standard, Diagnostik, Chirurgie, chromosomale, Tumorentstehung, Diagnose, gezielter, Biopsieentnahme, Chirurgie, Diagnostik, Tumoren, Haeute	DerChirurg.00710877.ger.abstr_task2	Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .	[ "Zusammenfassung", ".", "Die", "Incidenz", "primaerer", "maligner", "Neubildungen", "der", "Pleura", ",", "des", "Perikards", "und", "des", "Peritoneums", "steigt", "seit", "Mitte", "der", "80", "er", "Jahre", "aufgrund", "der", "in", "Deutschland", "zwischen", "1965", "und", "1980", "teilweise", "erheblichen", "Asbestgefaehrdung", "in", "zahlreichen", "Industriezweigen", "kontinuierlich", "an", ".", "Mit", "einem", "weiteren", "Anstieg", "bis", "etwa", "2020", "ist", "zu", "rechnen", ".", "Etwa", "90", "%", "aller", "im", "Deutschen", "Mesotheliomregister", "erfassten", "Mesotheliome", "sind", "asbestassoziiert", "und", "somit", "als", "potenzielle", "Berufskrankheiten", "einzuordnen", ".", "Derzeit", "werden", "im", "Deutschen", "Mesotheliomregister", "in", "Bochum", "jaehrlich", "mehr", "als", "500", "Mesotheliome", "erfasst", ".", "Im", "ersten", "Teil", "der", "Serie", "ueber", "Mesotheliome", "werden", "aktuelle", "Konzepte", "zu", "Aetiologie", "und", "Pathogenese", "sowie", "der", "derzeitige", "Standard", "der", "Diagnostik", "vor", "dem", "Hintergrund", "der", "zunehmenden", "Aktualitaet", "fuer", "das", "Fachgebiet", "der", "Chirurgie", "referiert", ".", "Spezifische", "chromosomale", "oder", "genetische", "Defekte", ",", "die", "konstant", "zur", "Entwicklung", "maligner", "Mesotheliome", "fuehren", ",", "sind", "derzeit", "nicht", "bekannt", ".", "Vielmehr", "handelt", "es", "sich", "bei", "der", "Tumorentstehung", "um", "einen", "komplexen", "Vorgang", ",", "dem", "individuell", "unterschiedliche", "genetische", "Veraenderungen", "zugrundeliegen", ".", "Basis", "fuer", "therapeutische", ",", "prognostische", "und", "versicherungsmedizinische", "Konsequenzen", "ist", "eine", "verlaessliche", "Diagnose", ",", "die", "in", "der", "Regel", "zuverlaessig", "durch", "thoracoskopische", "Inspektionen", "mit", "gezielter", "Biopsieentnahme", "erzielt", "werden", "kann", ".", "Die", "Chirurgie", "kann", "unter", "der", "Voraussetzung", "einer", "verbesserten", "Diagnostik", "mit", "Erfassung", "frueher", "Entwicklungsphasen", "maligner", "Tumoren", "der", "seroesen", "Haeute", "zunehmende", "Bedeutung", "im", "Hinblick", "auf", "operative", "therapeutische", "Verfahren", "nicht", "nur", "zur", "Palliation", ",", "sondern", "auch", "unter", "kurativen", "Gesichtspunkten", "gewinnen", "." ]	[ "umlsterm" ]
Interleukin-3 expression is an other_name, activated T cells is a cell_type, T - cell - specific factor is a protein_family_or_group, octamer binding protein is a protein_domain_or_region	84492_task0	Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, protein_domain_or_region, other_name	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.	[ "Interleukin-3", "expression", "by", "activated", "T", "cells", "involves", "an", "inducible", ",", "T", "-", "cell", "-", "specific", "factor", "and", "an", "octamer", "binding", "protein", "." ]	[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]
Interleukin-3 expression is an other_name, activated T cells is a cell_type, T - cell - specific factor is a protein_family_or_group, octamer binding protein is a protein_domain_or_region	84492_task1	Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please typing these entity words according to sentence: Interleukin-3 expression, activated T cells, T - cell - specific factor, octamer binding protein Options: cell_type, protein_family_or_group, protein_domain_or_region, other_name	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.	[ "Interleukin-3", "expression", "by", "activated", "T", "cells", "involves", "an", "inducible", ",", "T", "-", "cell", "-", "specific", "factor", "and", "an", "octamer", "binding", "protein", "." ]	[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]
Interleukin-3 expression, activated T cells, T - cell - specific factor, octamer binding protein	84492_task2	Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please extract entity words from the input sentence	[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.	[ "Interleukin-3", "expression", "by", "activated", "T", "cells", "involves", "an", "inducible", ",", "T", "-", "cell", "-", "specific", "factor", "and", "an", "octamer", "binding", "protein", "." ]	[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]
Behandlung is an umlsterm, Radiusfrakturen is an umlsterm, Frakturreposition is an umlsterm, Zusatzverletzungen is an umlsterm, Bandverbindungen is an umlsterm, Zusatzverletzungen is an umlsterm, Therapie is an umlsterm, Radiusfrakturen is an umlsterm, Frakturen is an umlsterm, Bandlaesionen is an umlsterm, Patienten is an umlsterm	DerUnfallchirurg.71000430.ger.abstr_task0	Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .	[ "Das", "Endergebnis", "der", "Behandlung", "distaler", "intraartikulaerer", "Radiusfrakturen", "ist", "sowohl", "von", "der", "Frakturreposition", "als", "auch", "von", "eventuellen", "Zusatzverletzungen", "abhaengig", ".", "Vor", "allem", "Laesionen", "der", "karpalen", "Bandverbindungen", "fuehren", "unbehandelt", "zu", "ausgepraegten", "degenerativen", "Schaedigungen", ".", "Durch", "zunehmenden", "Einsatz", "der", "Handgelenkarthroskopie", "koennen", "diese", "Zusatzverletzungen", "fruehzeitig", "diagnostiziert", "und", "einer", "adaequaten", "Therapie", "zugefuehrt", "werden", ".", "Seit", "1993", "haben", "wir", "23", "distale", "intraartikulaere", "Radiusfrakturen", "(", "vornehmlich", "C", "-", "Frakturen", "nach", "AO", "bzw", ".", "Frakturen", "der", "Gruppen", "VII", "und", "VIII", "nach", "Frykman", ")", "arthroskopisch", "assistiert", "versorgt", ",", "wobei", "wir", "in", "11", "Faellen", "(", "47,8", "%", "skapholunaere", "Bandlaesionen", ")", "feststellen", "konnten", ";", "7", "dieser", "Patienten", "(", "64", "%", ")", "waren", "arthroskopisch", "und", "bei", "der", "intraoperativen", "Pruefung", "instabil", "und", "wurden", "in", "der", "selben", "Sitzung", "minimal", "-", "invasiv", "stabilisiert", "." ]	[ "umlsterm" ]
Behandlung is an umlsterm, Radiusfrakturen is an umlsterm, Frakturreposition is an umlsterm, Zusatzverletzungen is an umlsterm, Bandverbindungen is an umlsterm, Zusatzverletzungen is an umlsterm, Therapie is an umlsterm, Radiusfrakturen is an umlsterm, Frakturen is an umlsterm, Bandlaesionen is an umlsterm, Patienten is an umlsterm	DerUnfallchirurg.71000430.ger.abstr_task1	Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please typing these entity words according to sentence: Behandlung, Radiusfrakturen, Frakturreposition, Zusatzverletzungen, Bandverbindungen, Zusatzverletzungen, Therapie, Radiusfrakturen, Frakturen, Bandlaesionen, Patienten Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .	[ "Das", "Endergebnis", "der", "Behandlung", "distaler", "intraartikulaerer", "Radiusfrakturen", "ist", "sowohl", "von", "der", "Frakturreposition", "als", "auch", "von", "eventuellen", "Zusatzverletzungen", "abhaengig", ".", "Vor", "allem", "Laesionen", "der", "karpalen", "Bandverbindungen", "fuehren", "unbehandelt", "zu", "ausgepraegten", "degenerativen", "Schaedigungen", ".", "Durch", "zunehmenden", "Einsatz", "der", "Handgelenkarthroskopie", "koennen", "diese", "Zusatzverletzungen", "fruehzeitig", "diagnostiziert", "und", "einer", "adaequaten", "Therapie", "zugefuehrt", "werden", ".", "Seit", "1993", "haben", "wir", "23", "distale", "intraartikulaere", "Radiusfrakturen", "(", "vornehmlich", "C", "-", "Frakturen", "nach", "AO", "bzw", ".", "Frakturen", "der", "Gruppen", "VII", "und", "VIII", "nach", "Frykman", ")", "arthroskopisch", "assistiert", "versorgt", ",", "wobei", "wir", "in", "11", "Faellen", "(", "47,8", "%", "skapholunaere", "Bandlaesionen", ")", "feststellen", "konnten", ";", "7", "dieser", "Patienten", "(", "64", "%", ")", "waren", "arthroskopisch", "und", "bei", "der", "intraoperativen", "Pruefung", "instabil", "und", "wurden", "in", "der", "selben", "Sitzung", "minimal", "-", "invasiv", "stabilisiert", "." ]	[ "umlsterm" ]
Behandlung, Radiusfrakturen, Frakturreposition, Zusatzverletzungen, Bandverbindungen, Zusatzverletzungen, Therapie, Radiusfrakturen, Frakturen, Bandlaesionen, Patienten	DerUnfallchirurg.71000430.ger.abstr_task2	Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .	[ "Das", "Endergebnis", "der", "Behandlung", "distaler", "intraartikulaerer", "Radiusfrakturen", "ist", "sowohl", "von", "der", "Frakturreposition", "als", "auch", "von", "eventuellen", "Zusatzverletzungen", "abhaengig", ".", "Vor", "allem", "Laesionen", "der", "karpalen", "Bandverbindungen", "fuehren", "unbehandelt", "zu", "ausgepraegten", "degenerativen", "Schaedigungen", ".", "Durch", "zunehmenden", "Einsatz", "der", "Handgelenkarthroskopie", "koennen", "diese", "Zusatzverletzungen", "fruehzeitig", "diagnostiziert", "und", "einer", "adaequaten", "Therapie", "zugefuehrt", "werden", ".", "Seit", "1993", "haben", "wir", "23", "distale", "intraartikulaere", "Radiusfrakturen", "(", "vornehmlich", "C", "-", "Frakturen", "nach", "AO", "bzw", ".", "Frakturen", "der", "Gruppen", "VII", "und", "VIII", "nach", "Frykman", ")", "arthroskopisch", "assistiert", "versorgt", ",", "wobei", "wir", "in", "11", "Faellen", "(", "47,8", "%", "skapholunaere", "Bandlaesionen", ")", "feststellen", "konnten", ";", "7", "dieser", "Patienten", "(", "64", "%", ")", "waren", "arthroskopisch", "und", "bei", "der", "intraoperativen", "Pruefung", "instabil", "und", "wurden", "in", "der", "selben", "Sitzung", "minimal", "-", "invasiv", "stabilisiert", "." ]	[ "umlsterm" ]
XIST is a Protein, XIST is a Protein, XIST is a Protein, histone H4 is a Protein, ZXDA is a Protein, ZXDB is a Protein, PHKA1 is a Protein, XIST is a Protein, XIST is a Protein	8079992_task0	Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "The", "severe", "phenotype", "of", "females", "with", "tiny", "ring", "X", "chromosomes", "is", "associated", "with", "inability", "of", "these", "chromosomes", "to", "undergo", "X", "inactivation", ".", "\n", "Mental", "retardation", "and", "a", "constellation", "of", "congenital", "malformations", "not", "usually", "associated", "with", "Turner", "syndrome", "are", "seen", "in", "some", "females", "with", "a", "mosaic", "45,X/46,X", ",", "r(X", ")", "karyotype", ".", "Studies", "of", "these", "females", "show", "that", "the", "XIST", "locus", "on", "their", "tiny", "ring", "X", "chromosomes", "is", "either", "not", "present", "or", "not", "expressed", ".", "As", "XIST", "transcription", "is", "well", "correlated", "with", "inactivation", "of", "the", "X", "chromosome", "in", "female", "somatic", "cells", "and", "spermatogonia", ",", "nonexpression", "of", "the", "locus", "even", "when", "it", "is", "present", "suggests", "that", "these", "chromosomes", "are", "transcriptionally", "active", ".", "We", "examined", "the", "transcriptional", "activity", "of", "ring", "X", "chromosomes", "lacking", "XIST", "expression", "(", "XISTE-", ")", ",", "from", "three", "females", "with", "severe", "phenotypes", ".", "The", "two", "tiny", "ring", "X", "chromosomes", "studied", "with", "an", "antibody", "specific", "for", "the", "acetylated", "isoforms", "of", "histone", "H4", "marking", "transcribed", "chromatin", "domains", "were", "labeled", "at", "a", "level", "consistent", "with", "their", "being", "active", ".", "We", "also", "examined", "tow", "of", "the", "XISTE-", "ring", "chromosomes", "to", "determine", "whether", "genes", "that", "are", "normally", "silent", "on", "an", "inactive", "X", "are", "expressed", "from", "these", "chromosomes", ".", "Analyses", "of", "hybrid", "cells", "show", "that", "TIMP", ",", "ZXDA", ",", "and", "ZXDB", "loci", "on", "the", "proximal", "short", "arm", ",", "and", "AR", "and", "PHKA1", "loci", "on", "the", "long", "arm", ",", "are", "well", "expressed", "from", "the", "tiny", "ring", "X", "chromosome", "lacking", "XIST", "DNA", ".", "Studies", "of", "the", "ring", "chromosome", "that", "has", "XIST", "DNA", "but", "does", "not", "transcribe", "it", "show", "that", "its", "AR", "allele", "is", "transcribed", "along", "with", "the", "one", "on", "the", "normal", "X", "allele", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
XIST is a Protein, XIST is a Protein, XIST is a Protein, histone H4 is a Protein, ZXDA is a Protein, ZXDB is a Protein, PHKA1 is a Protein, XIST is a Protein, XIST is a Protein	8079992_task1	Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: XIST, XIST, XIST, histone H4, ZXDA, ZXDB, PHKA1, XIST, XIST Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "The", "severe", "phenotype", "of", "females", "with", "tiny", "ring", "X", "chromosomes", "is", "associated", "with", "inability", "of", "these", "chromosomes", "to", "undergo", "X", "inactivation", ".", "\n", "Mental", "retardation", "and", "a", "constellation", "of", "congenital", "malformations", "not", "usually", "associated", "with", "Turner", "syndrome", "are", "seen", "in", "some", "females", "with", "a", "mosaic", "45,X/46,X", ",", "r(X", ")", "karyotype", ".", "Studies", "of", "these", "females", "show", "that", "the", "XIST", "locus", "on", "their", "tiny", "ring", "X", "chromosomes", "is", "either", "not", "present", "or", "not", "expressed", ".", "As", "XIST", "transcription", "is", "well", "correlated", "with", "inactivation", "of", "the", "X", "chromosome", "in", "female", "somatic", "cells", "and", "spermatogonia", ",", "nonexpression", "of", "the", "locus", "even", "when", "it", "is", "present", "suggests", "that", "these", "chromosomes", "are", "transcriptionally", "active", ".", "We", "examined", "the", "transcriptional", "activity", "of", "ring", "X", "chromosomes", "lacking", "XIST", "expression", "(", "XISTE-", ")", ",", "from", "three", "females", "with", "severe", "phenotypes", ".", "The", "two", "tiny", "ring", "X", "chromosomes", "studied", "with", "an", "antibody", "specific", "for", "the", "acetylated", "isoforms", "of", "histone", "H4", "marking", "transcribed", "chromatin", "domains", "were", "labeled", "at", "a", "level", "consistent", "with", "their", "being", "active", ".", "We", "also", "examined", "tow", "of", "the", "XISTE-", "ring", "chromosomes", "to", "determine", "whether", "genes", "that", "are", "normally", "silent", "on", "an", "inactive", "X", "are", "expressed", "from", "these", "chromosomes", ".", "Analyses", "of", "hybrid", "cells", "show", "that", "TIMP", ",", "ZXDA", ",", "and", "ZXDB", "loci", "on", "the", "proximal", "short", "arm", ",", "and", "AR", "and", "PHKA1", "loci", "on", "the", "long", "arm", ",", "are", "well", "expressed", "from", "the", "tiny", "ring", "X", "chromosome", "lacking", "XIST", "DNA", ".", "Studies", "of", "the", "ring", "chromosome", "that", "has", "XIST", "DNA", "but", "does", "not", "transcribe", "it", "show", "that", "its", "AR", "allele", "is", "transcribed", "along", "with", "the", "one", "on", "the", "normal", "X", "allele", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
XIST, XIST, XIST, histone H4, ZXDA, ZXDB, PHKA1, XIST, XIST	8079992_task2	Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "The", "severe", "phenotype", "of", "females", "with", "tiny", "ring", "X", "chromosomes", "is", "associated", "with", "inability", "of", "these", "chromosomes", "to", "undergo", "X", "inactivation", ".", "\n", "Mental", "retardation", "and", "a", "constellation", "of", "congenital", "malformations", "not", "usually", "associated", "with", "Turner", "syndrome", "are", "seen", "in", "some", "females", "with", "a", "mosaic", "45,X/46,X", ",", "r(X", ")", "karyotype", ".", "Studies", "of", "these", "females", "show", "that", "the", "XIST", "locus", "on", "their", "tiny", "ring", "X", "chromosomes", "is", "either", "not", "present", "or", "not", "expressed", ".", "As", "XIST", "transcription", "is", "well", "correlated", "with", "inactivation", "of", "the", "X", "chromosome", "in", "female", "somatic", "cells", "and", "spermatogonia", ",", "nonexpression", "of", "the", "locus", "even", "when", "it", "is", "present", "suggests", "that", "these", "chromosomes", "are", "transcriptionally", "active", ".", "We", "examined", "the", "transcriptional", "activity", "of", "ring", "X", "chromosomes", "lacking", "XIST", "expression", "(", "XISTE-", ")", ",", "from", "three", "females", "with", "severe", "phenotypes", ".", "The", "two", "tiny", "ring", "X", "chromosomes", "studied", "with", "an", "antibody", "specific", "for", "the", "acetylated", "isoforms", "of", "histone", "H4", "marking", "transcribed", "chromatin", "domains", "were", "labeled", "at", "a", "level", "consistent", "with", "their", "being", "active", ".", "We", "also", "examined", "tow", "of", "the", "XISTE-", "ring", "chromosomes", "to", "determine", "whether", "genes", "that", "are", "normally", "silent", "on", "an", "inactive", "X", "are", "expressed", "from", "these", "chromosomes", ".", "Analyses", "of", "hybrid", "cells", "show", "that", "TIMP", ",", "ZXDA", ",", "and", "ZXDB", "loci", "on", "the", "proximal", "short", "arm", ",", "and", "AR", "and", "PHKA1", "loci", "on", "the", "long", "arm", ",", "are", "well", "expressed", "from", "the", "tiny", "ring", "X", "chromosome", "lacking", "XIST", "DNA", ".", "Studies", "of", "the", "ring", "chromosome", "that", "has", "XIST", "DNA", "but", "does", "not", "transcribe", "it", "show", "that", "its", "AR", "allele", "is", "transcribed", "along", "with", "the", "one", "on", "the", "normal", "X", "allele", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
bone marrow of patients with acute myeloid leukemia . is a Participant_Condition, immunohistochemical analysis of bone marrow biopsies is a Intervention_Physical, Expression of VEGF and VEGFR-2 is a Outcome_Physical, remission is a Outcome_Physical, induction chemotherapy is a Intervention_Pharmacological, VEGFR-2 staining levels is a Outcome_Physical, VEGF / VEGFR-2 of leukemic blasts is a Outcome_Physical, antiangiogenic is a Intervention_Other	9728_task0	Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Intervention_Other, Outcome_Physical	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O" ]	Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .	[ "Overexpression", "of", "vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "KDR", "(", "VEGFR-2", ")", "in", "the", "bone", "marrow", "of", "patients", "with", "acute", "myeloid", "leukemia", ".", "Vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "VEGFR-2", "have", "been", "implicated", "as", "the", "main", "endothelial", "pathway", "required", "for", "tumor", "neovascularization", ".", "However", ",", "the", "importance", "of", "the", "VEGF", "/", "VEGFR-2", "system", "for", "angiogenesis", "in", "hematologic", "malignancies", "such", "as", "AML", "remains", "to", "be", "elucidated", ".", "In", "32", "patients", "with", "newly", "diagnosed", "untreated", "AML", ",", "we", "observed", "by", "immunohistochemical", "analysis", "of", "bone", "marrow", "biopsies", "significantly", "higher", "levels", "of", "VEGF", "and", "VEGFR-2", "expression", "than", "in", "10", "control", "patients", "(", "P", "<", "0.001", ")", ".", "In", "contrast", ",", "VEGFR-1", "staining", "levels", "in", "AML", "patients", "were", "in", "the", "same", "range", "as", "in", "the", "controls", ".", "Expression", "of", "VEGF", "and", "VEGFR-2", "was", "significantly", "higher", "in", "patients", "with", "a", "high", "degree", "of", "microvessel", "density", "compared", "to", "those", "with", "a", "low", "degree", "(", "VEGF", ":", "P", "=", "0.024", ";", "VEGFR-2", ":", "P", "=", "0.040", ")", "and", "correlated", "well", "with", "bone", "marrow", "microvessel", "density", "(", "r", "(", "s", ")", "=", "0.566", "and", "0.609", ",", "respectively", ";", "P", "<", "0.001", ")", ".", "Furthermore", ",", "in", "patients", "who", "achieved", "a", "complete", "remission", "following", "induction", "chemotherapy", "VEGFR-2", "staining", "levels", "decreased", "into", "the", "normal", "range", ".", "In", "conclusion", ",", "our", "results", "provide", "evidence", "for", "increased", "expression", "of", "VEGF", "/", "VEGFR-2", "of", "leukemic", "blasts", "and", "correlation", "with", "angiogenesis", "in", "the", "bone", "marrow", "of", "AML", "patients", ".", "Thus", ",", "VEGF", "/", "VEGFR-2", "might", "constitute", "promising", "targets", "for", "antiangiogenic", "and", "antileukemic", "treatment", "strategies", "in", "AML", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]
bone marrow of patients with acute myeloid leukemia . is a Participant_Condition, immunohistochemical analysis of bone marrow biopsies is a Intervention_Physical, Expression of VEGF and VEGFR-2 is a Outcome_Physical, remission is a Outcome_Physical, induction chemotherapy is a Intervention_Pharmacological, VEGFR-2 staining levels is a Outcome_Physical, VEGF / VEGFR-2 of leukemic blasts is a Outcome_Physical, antiangiogenic is a Intervention_Other	9728_task1	Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please typing these entity words according to sentence: bone marrow of patients with acute myeloid leukemia ., immunohistochemical analysis of bone marrow biopsies, Expression of VEGF and VEGFR-2, remission, induction chemotherapy, VEGFR-2 staining levels, VEGF / VEGFR-2 of leukemic blasts, antiangiogenic Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Intervention_Other, Outcome_Physical	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O" ]	Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .	[ "Overexpression", "of", "vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "KDR", "(", "VEGFR-2", ")", "in", "the", "bone", "marrow", "of", "patients", "with", "acute", "myeloid", "leukemia", ".", "Vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "VEGFR-2", "have", "been", "implicated", "as", "the", "main", "endothelial", "pathway", "required", "for", "tumor", "neovascularization", ".", "However", ",", "the", "importance", "of", "the", "VEGF", "/", "VEGFR-2", "system", "for", "angiogenesis", "in", "hematologic", "malignancies", "such", "as", "AML", "remains", "to", "be", "elucidated", ".", "In", "32", "patients", "with", "newly", "diagnosed", "untreated", "AML", ",", "we", "observed", "by", "immunohistochemical", "analysis", "of", "bone", "marrow", "biopsies", "significantly", "higher", "levels", "of", "VEGF", "and", "VEGFR-2", "expression", "than", "in", "10", "control", "patients", "(", "P", "<", "0.001", ")", ".", "In", "contrast", ",", "VEGFR-1", "staining", "levels", "in", "AML", "patients", "were", "in", "the", "same", "range", "as", "in", "the", "controls", ".", "Expression", "of", "VEGF", "and", "VEGFR-2", "was", "significantly", "higher", "in", "patients", "with", "a", "high", "degree", "of", "microvessel", "density", "compared", "to", "those", "with", "a", "low", "degree", "(", "VEGF", ":", "P", "=", "0.024", ";", "VEGFR-2", ":", "P", "=", "0.040", ")", "and", "correlated", "well", "with", "bone", "marrow", "microvessel", "density", "(", "r", "(", "s", ")", "=", "0.566", "and", "0.609", ",", "respectively", ";", "P", "<", "0.001", ")", ".", "Furthermore", ",", "in", "patients", "who", "achieved", "a", "complete", "remission", "following", "induction", "chemotherapy", "VEGFR-2", "staining", "levels", "decreased", "into", "the", "normal", "range", ".", "In", "conclusion", ",", "our", "results", "provide", "evidence", "for", "increased", "expression", "of", "VEGF", "/", "VEGFR-2", "of", "leukemic", "blasts", "and", "correlation", "with", "angiogenesis", "in", "the", "bone", "marrow", "of", "AML", "patients", ".", "Thus", ",", "VEGF", "/", "VEGFR-2", "might", "constitute", "promising", "targets", "for", "antiangiogenic", "and", "antileukemic", "treatment", "strategies", "in", "AML", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]
bone marrow of patients with acute myeloid leukemia ., immunohistochemical analysis of bone marrow biopsies, Expression of VEGF and VEGFR-2, remission, induction chemotherapy, VEGFR-2 staining levels, VEGF / VEGFR-2 of leukemic blasts, antiangiogenic	9728_task2	Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O" ]	Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .	[ "Overexpression", "of", "vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "KDR", "(", "VEGFR-2", ")", "in", "the", "bone", "marrow", "of", "patients", "with", "acute", "myeloid", "leukemia", ".", "Vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", "and", "its", "cellular", "receptor", "VEGFR-2", "have", "been", "implicated", "as", "the", "main", "endothelial", "pathway", "required", "for", "tumor", "neovascularization", ".", "However", ",", "the", "importance", "of", "the", "VEGF", "/", "VEGFR-2", "system", "for", "angiogenesis", "in", "hematologic", "malignancies", "such", "as", "AML", "remains", "to", "be", "elucidated", ".", "In", "32", "patients", "with", "newly", "diagnosed", "untreated", "AML", ",", "we", "observed", "by", "immunohistochemical", "analysis", "of", "bone", "marrow", "biopsies", "significantly", "higher", "levels", "of", "VEGF", "and", "VEGFR-2", "expression", "than", "in", "10", "control", "patients", "(", "P", "<", "0.001", ")", ".", "In", "contrast", ",", "VEGFR-1", "staining", "levels", "in", "AML", "patients", "were", "in", "the", "same", "range", "as", "in", "the", "controls", ".", "Expression", "of", "VEGF", "and", "VEGFR-2", "was", "significantly", "higher", "in", "patients", "with", "a", "high", "degree", "of", "microvessel", "density", "compared", "to", "those", "with", "a", "low", "degree", "(", "VEGF", ":", "P", "=", "0.024", ";", "VEGFR-2", ":", "P", "=", "0.040", ")", "and", "correlated", "well", "with", "bone", "marrow", "microvessel", "density", "(", "r", "(", "s", ")", "=", "0.566", "and", "0.609", ",", "respectively", ";", "P", "<", "0.001", ")", ".", "Furthermore", ",", "in", "patients", "who", "achieved", "a", "complete", "remission", "following", "induction", "chemotherapy", "VEGFR-2", "staining", "levels", "decreased", "into", "the", "normal", "range", ".", "In", "conclusion", ",", "our", "results", "provide", "evidence", "for", "increased", "expression", "of", "VEGF", "/", "VEGFR-2", "of", "leukemic", "blasts", "and", "correlation", "with", "angiogenesis", "in", "the", "bone", "marrow", "of", "AML", "patients", ".", "Thus", ",", "VEGF", "/", "VEGFR-2", "might", "constitute", "promising", "targets", "for", "antiangiogenic", "and", "antileukemic", "treatment", "strategies", "in", "AML", "." ]	[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]
Patienten is an umlsterm, rueckenmarknaher is an umlsterm, Regionalanaesthesie is an umlsterm, Sauerstoffpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Haemodynamik is an umlsterm, Blutdruck is an umlsterm	DerAnaesthesist.90480379.ger.abstr_task0	Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .	[ "Fragestellung", ":", "Ziel", "unserer", "Untersuchung", "war", "es", ",", "moegliche", "kognitive", "Funktionsdefizite", "geriatrischer", "Patienten", "nach", "Allgemein-", "und", "rueckenmarknaher", "Regionalanaesthesie", "mit", "Parametern", "des", "Gasaustauschs", "(", "Sauerstoffpartialdruck", "paO2", ",", "Sauerstoffsaettigung", "SatO2", ")", "und", "der", "Haemodynamik", "(", "arterieller", "systolischer", "und", "mittlerer", "Blutdruck", "RRs", "und", "MAP", ")", "in", "Beziehung", "zu", "setzen", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, rueckenmarknaher is an umlsterm, Regionalanaesthesie is an umlsterm, Sauerstoffpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Haemodynamik is an umlsterm, Blutdruck is an umlsterm	DerAnaesthesist.90480379.ger.abstr_task1	Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please typing these entity words according to sentence: Patienten, rueckenmarknaher, Regionalanaesthesie, Sauerstoffpartialdruck, Sauerstoffsaettigung, Haemodynamik, Blutdruck Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .	[ "Fragestellung", ":", "Ziel", "unserer", "Untersuchung", "war", "es", ",", "moegliche", "kognitive", "Funktionsdefizite", "geriatrischer", "Patienten", "nach", "Allgemein-", "und", "rueckenmarknaher", "Regionalanaesthesie", "mit", "Parametern", "des", "Gasaustauschs", "(", "Sauerstoffpartialdruck", "paO2", ",", "Sauerstoffsaettigung", "SatO2", ")", "und", "der", "Haemodynamik", "(", "arterieller", "systolischer", "und", "mittlerer", "Blutdruck", "RRs", "und", "MAP", ")", "in", "Beziehung", "zu", "setzen", "." ]	[ "umlsterm" ]
Patienten, rueckenmarknaher, Regionalanaesthesie, Sauerstoffpartialdruck, Sauerstoffsaettigung, Haemodynamik, Blutdruck	DerAnaesthesist.90480379.ger.abstr_task2	Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .	[ "Fragestellung", ":", "Ziel", "unserer", "Untersuchung", "war", "es", ",", "moegliche", "kognitive", "Funktionsdefizite", "geriatrischer", "Patienten", "nach", "Allgemein-", "und", "rueckenmarknaher", "Regionalanaesthesie", "mit", "Parametern", "des", "Gasaustauschs", "(", "Sauerstoffpartialdruck", "paO2", ",", "Sauerstoffsaettigung", "SatO2", ")", "und", "der", "Haemodynamik", "(", "arterieller", "systolischer", "und", "mittlerer", "Blutdruck", "RRs", "und", "MAP", ")", "in", "Beziehung", "zu", "setzen", "." ]	[ "umlsterm" ]
devices is an umlsterm, heart is an umlsterm, devices is an umlsterm, patients is an umlsterm, heart transplantation is an umlsterm, devices is an umlsterm, patient selection is an umlsterm, patient care is an umlsterm, device is an umlsterm, maintenance is an umlsterm, patients is an umlsterm, devices is an umlsterm, secondary is an umlsterm, heart is an umlsterm, function is an umlsterm, patients is an umlsterm, costs is an umlsterm, patients is an umlsterm	ZfuerKardiologie.0089vii91.eng.abstr_task0	Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .	[ "Mechanical", "circulatory", "support", "devices", "were", "first", "developed", "to", "permanently", "replace", "the", "failing", "heart", ".", "Today", ",", "however", ",", "the", "majority", "of", "these", "devices", "are", "used", "as", "a", "mechanical", "bridge", "in", "patients", "awaiting", "heart", "transplantation", ".", "With", "this", "indication", ",", "important", "information", "on", "using", "mechanical", "assist", "devices", "has", "been", "assembled", ".", "We", "present", "our", "experience", ",", "which", "has", "been", "gained", "since", "1987", "in", "the", "area", "of", "patient", "selection", ",", "post", "-", "implant", "patient", "care", "and", "device", "maintenance", ".", "More", "than", "450", "patients", "have", "since", "been", "implanted", "with", "assist", "devices", "at", "our", "institution", ".", "Mechanical", "circulatory", "support", "may", "not", "only", "lead", "to", "recovery", "from", "secondary", "organ", "failure", ",", "but", "also", "to", "myocardial", "reremodeling", "and", "recovery", "of", "the", "heart", "function", "in", "some", "patients", ".", "Additionally", "we", "report", "our", "experience", "with", "a", "newly", "developed", "implantable", "axial", "flow", "pump", "and", "discuss", "the", "possibility", "and", "costs", "of", "permanent", "support", "in", "some", "patients", "." ]	[ "umlsterm" ]
devices is an umlsterm, heart is an umlsterm, devices is an umlsterm, patients is an umlsterm, heart transplantation is an umlsterm, devices is an umlsterm, patient selection is an umlsterm, patient care is an umlsterm, device is an umlsterm, maintenance is an umlsterm, patients is an umlsterm, devices is an umlsterm, secondary is an umlsterm, heart is an umlsterm, function is an umlsterm, patients is an umlsterm, costs is an umlsterm, patients is an umlsterm	ZfuerKardiologie.0089vii91.eng.abstr_task1	Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please typing these entity words according to sentence: devices, heart, devices, patients, heart transplantation, devices, patient selection, patient care, device, maintenance, patients, devices, secondary, heart, function, patients, costs, patients Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .	[ "Mechanical", "circulatory", "support", "devices", "were", "first", "developed", "to", "permanently", "replace", "the", "failing", "heart", ".", "Today", ",", "however", ",", "the", "majority", "of", "these", "devices", "are", "used", "as", "a", "mechanical", "bridge", "in", "patients", "awaiting", "heart", "transplantation", ".", "With", "this", "indication", ",", "important", "information", "on", "using", "mechanical", "assist", "devices", "has", "been", "assembled", ".", "We", "present", "our", "experience", ",", "which", "has", "been", "gained", "since", "1987", "in", "the", "area", "of", "patient", "selection", ",", "post", "-", "implant", "patient", "care", "and", "device", "maintenance", ".", "More", "than", "450", "patients", "have", "since", "been", "implanted", "with", "assist", "devices", "at", "our", "institution", ".", "Mechanical", "circulatory", "support", "may", "not", "only", "lead", "to", "recovery", "from", "secondary", "organ", "failure", ",", "but", "also", "to", "myocardial", "reremodeling", "and", "recovery", "of", "the", "heart", "function", "in", "some", "patients", ".", "Additionally", "we", "report", "our", "experience", "with", "a", "newly", "developed", "implantable", "axial", "flow", "pump", "and", "discuss", "the", "possibility", "and", "costs", "of", "permanent", "support", "in", "some", "patients", "." ]	[ "umlsterm" ]
devices, heart, devices, patients, heart transplantation, devices, patient selection, patient care, device, maintenance, patients, devices, secondary, heart, function, patients, costs, patients	ZfuerKardiologie.0089vii91.eng.abstr_task2	Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .	[ "Mechanical", "circulatory", "support", "devices", "were", "first", "developed", "to", "permanently", "replace", "the", "failing", "heart", ".", "Today", ",", "however", ",", "the", "majority", "of", "these", "devices", "are", "used", "as", "a", "mechanical", "bridge", "in", "patients", "awaiting", "heart", "transplantation", ".", "With", "this", "indication", ",", "important", "information", "on", "using", "mechanical", "assist", "devices", "has", "been", "assembled", ".", "We", "present", "our", "experience", ",", "which", "has", "been", "gained", "since", "1987", "in", "the", "area", "of", "patient", "selection", ",", "post", "-", "implant", "patient", "care", "and", "device", "maintenance", ".", "More", "than", "450", "patients", "have", "since", "been", "implanted", "with", "assist", "devices", "at", "our", "institution", ".", "Mechanical", "circulatory", "support", "may", "not", "only", "lead", "to", "recovery", "from", "secondary", "organ", "failure", ",", "but", "also", "to", "myocardial", "reremodeling", "and", "recovery", "of", "the", "heart", "function", "in", "some", "patients", ".", "Additionally", "we", "report", "our", "experience", "with", "a", "newly", "developed", "implantable", "axial", "flow", "pump", "and", "discuss", "the", "possibility", "and", "costs", "of", "permanent", "support", "in", "some", "patients", "." ]	[ "umlsterm" ]
carbon is a CHEMICAL	12668769_task0	Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.	[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
carbon is a CHEMICAL	12668769_task1	Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please typing these entity words according to sentence: carbon Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.	[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
carbon	12668769_task2	Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.	[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
EUROSCAN is a Intervention_Physical	31917_task0	Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical	[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]	The EUROSCAN Study . EUROSCAN Steering Committee .	[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]	[ "Intervention_Physical", "Participant_Condition" ]
EUROSCAN is a Intervention_Physical	31917_task1	Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please typing these entity words according to sentence: EUROSCAN Options: Intervention_Physical	[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]	The EUROSCAN Study . EUROSCAN Steering Committee .	[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]	[ "Intervention_Physical", "Participant_Condition" ]
EUROSCAN	31917_task2	Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please extract entity words from the input sentence	[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]	The EUROSCAN Study . EUROSCAN Steering Committee .	[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]	[ "Intervention_Physical", "Participant_Condition" ]
Estrogen receptor concentration is an other_name, social factors is an other_name, natural killer cell activity is an other_name, early - stage breast cancer patients is a multi_cell	100587_task0	Sentence: Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: multi_cell, other_name	[ "B-other_name", "I-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "O", "O", "O", "O", "O", "O" ]	Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model.	[ "Estrogen", "receptor", "concentration", "and", "social", "factors", "as", "predictors", "of", "natural", "killer", "cell", "activity", "in", "early", "-", "stage", "breast", "cancer", "patients", ".", "Confirmation", "of", "a", "model", "." ]	[ "other_name", "(AND multi_cell multi_cell)", "multi_cell", "", "protein_family_or_group", "cell_type", "tissue" ]
Estrogen receptor concentration is an other_name, social factors is an other_name, natural killer cell activity is an other_name, early - stage breast cancer patients is a multi_cell	100587_task1	Sentence: Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model. Instructions: please typing these entity words according to sentence: Estrogen receptor concentration, social factors, natural killer cell activity, early - stage breast cancer patients Options: multi_cell, other_name	[ "B-other_name", "I-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "O", "O", "O", "O", "O", "O" ]	Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model.	[ "Estrogen", "receptor", "concentration", "and", "social", "factors", "as", "predictors", "of", "natural", "killer", "cell", "activity", "in", "early", "-", "stage", "breast", "cancer", "patients", ".", "Confirmation", "of", "a", "model", "." ]	[ "other_name", "(AND multi_cell multi_cell)", "multi_cell", "", "protein_family_or_group", "cell_type", "tissue" ]

Glucose is a CHEMICAL

23585333_task1

Sentence: Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering. Instructions: please typing these entity words according to sentence: Glucose Options: CHEMICAL

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering.

[ "Tandem", "Assays", "of", "Protein", "and", "Glucose", "with", "Functionalized", "Core", "/", "Shell", "Particles", "Based", "on", "Magnetic", "Separation", "and", "Surface", "-", "Enhanced", "Raman", "Scattering", "." ]

[ "CHEMICAL" ]

Glucose

23585333_task2

Sentence: Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering.

[ "Tandem", "Assays", "of", "Protein", "and", "Glucose", "with", "Functionalized", "Core", "/", "Shell", "Particles", "Based", "on", "Magnetic", "Separation", "and", "Surface", "-", "Enhanced", "Raman", "Scattering", "." ]

[ "CHEMICAL" ]

clonidine is an umlsterm, afferent neurons is an umlsterm, horn is an umlsterm, spinal cord is an umlsterm, analgesia is an umlsterm, inhibition is an umlsterm, analgesic is an umlsterm, time is an umlsterm, pain is an umlsterm, clonidine is an umlsterm, analgesia is an umlsterm, heart rate is an umlsterm, cardiac output is an umlsterm, blood pressure is an umlsterm, baseline is an umlsterm, haemodynamic is an umlsterm, side effects is an umlsterm, supervision is an umlsterm, use is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, analgesic is an umlsterm, opioid is an umlsterm, local anaesthetics is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, clonidine is an umlsterm, opioid is an umlsterm, local anaesthetic is an umlsterm, interactions is an umlsterm, drugs is an umlsterm

DerSchmerz.60100057.eng.abstr_task0

Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .

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[ "umlsterm" ]

clonidine is an umlsterm, afferent neurons is an umlsterm, horn is an umlsterm, spinal cord is an umlsterm, analgesia is an umlsterm, inhibition is an umlsterm, analgesic is an umlsterm, time is an umlsterm, pain is an umlsterm, clonidine is an umlsterm, analgesia is an umlsterm, heart rate is an umlsterm, cardiac output is an umlsterm, blood pressure is an umlsterm, baseline is an umlsterm, haemodynamic is an umlsterm, side effects is an umlsterm, supervision is an umlsterm, use is an umlsterm, clonidine is an umlsterm, patients is an umlsterm, analgesic is an umlsterm, opioid is an umlsterm, local anaesthetics is an umlsterm, patients is an umlsterm, clonidine is an umlsterm, clonidine is an umlsterm, opioid is an umlsterm, local anaesthetic is an umlsterm, interactions is an umlsterm, drugs is an umlsterm

DerSchmerz.60100057.eng.abstr_task1

Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please typing these entity words according to sentence: clonidine, afferent neurons, horn, spinal cord, analgesia, inhibition, analgesic, time, pain, clonidine, analgesia, heart rate, cardiac output, blood pressure, baseline, haemodynamic, side effects, supervision, use, clonidine, patients, analgesic, opioid, local anaesthetics, patients, clonidine, clonidine, opioid, local anaesthetic, interactions, drugs Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .

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[ "umlsterm" ]

clonidine, afferent neurons, horn, spinal cord, analgesia, inhibition, analgesic, time, pain, clonidine, analgesia, heart rate, cardiac output, blood pressure, baseline, haemodynamic, side effects, supervision, use, clonidine, patients, analgesic, opioid, local anaesthetics, patients, clonidine, clonidine, opioid, local anaesthetic, interactions, drugs

DerSchmerz.60100057.eng.abstr_task2

Sentence: Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs . Instructions: please extract entity words from the input sentence

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Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs .

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[ "umlsterm" ]

Tetrahydrobiopterin is a Intervention_Pharmacological, placebo - controlled is a Intervention_Control, Treatment - induced effects is a Outcome_Physical, Childhood Autism Rating Scale is a Outcome_Mental, total scores of Childhood Autism Rating Scale is a Outcome_Mental, social interaction , communication , and stereotyped behaviors is a Outcome_Mental, social interaction score is a Outcome_Mental, response of the social interaction score and IQ . is a Outcome_Mental

23558_task0

Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mental

[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .

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[ "Outcome_Mental", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

Tetrahydrobiopterin is a Intervention_Pharmacological, placebo - controlled is a Intervention_Control, Treatment - induced effects is a Outcome_Physical, Childhood Autism Rating Scale is a Outcome_Mental, total scores of Childhood Autism Rating Scale is a Outcome_Mental, social interaction , communication , and stereotyped behaviors is a Outcome_Mental, social interaction score is a Outcome_Mental, response of the social interaction score and IQ . is a Outcome_Mental

23558_task1

Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please typing these entity words according to sentence: Tetrahydrobiopterin, placebo - controlled, Treatment - induced effects, Childhood Autism Rating Scale, total scores of Childhood Autism Rating Scale, social interaction , communication , and stereotyped behaviors, social interaction score, response of the social interaction score and IQ . Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mental

[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .

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[ "Outcome_Mental", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

Tetrahydrobiopterin, placebo - controlled, Treatment - induced effects, Childhood Autism Rating Scale, total scores of Childhood Autism Rating Scale, social interaction , communication , and stereotyped behaviors, social interaction score, response of the social interaction score and IQ .

23558_task2

Sentence: Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .

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[ "Outcome_Mental", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

guamerin - derived peptide is a Entity, guamerin - derived synthetic peptide is a Entity, GDSP is a Entity, cerulein is a Entity, GDSP is a Entity, nuclear factor KB is a Entity, NF - KB is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, N - formyl - methionine - leucine - phenyl - alanine is a Entity, fMLP is a Entity, GDSP is a Entity, GDSP is a Entity

357_task0

Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity

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Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.

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[ "Entity" ]

guamerin - derived peptide is a Entity, guamerin - derived synthetic peptide is a Entity, GDSP is a Entity, cerulein is a Entity, GDSP is a Entity, nuclear factor KB is a Entity, NF - KB is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, GDSP is a Entity, N - formyl - methionine - leucine - phenyl - alanine is a Entity, fMLP is a Entity, GDSP is a Entity, GDSP is a Entity

357_task1

Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please typing these entity words according to sentence: guamerin - derived peptide, guamerin - derived synthetic peptide, GDSP, cerulein, GDSP, nuclear factor KB, NF - KB, GDSP, GDSP, GDSP, GDSP, N - formyl - methionine - leucine - phenyl - alanine, fMLP, GDSP, GDSP Options: Entity

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Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.

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[ "Entity" ]

guamerin - derived peptide, guamerin - derived synthetic peptide, GDSP, cerulein, GDSP, nuclear factor KB, NF - KB, GDSP, GDSP, GDSP, GDSP, N - formyl - methionine - leucine - phenyl - alanine, fMLP, GDSP, GDSP

357_task2

Sentence: Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis. Instructions: please extract entity words from the input sentence

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Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat. The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h. The effects of GDSP were also measured on superoxide formation by activated human neutrophils. The effects of GDSP were compared with those of another elastase inhibitor, elastatinal. GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein. GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA). Elastatinal had some of the same effects as GDSP but was less potent and effective. These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.

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[ "Entity" ]

Pax5 is a protein_molecule, haploinsufficiency is an other_name, mammalian Pax genes is a DNA_family_or_group

34672_task0

Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, other_name, protein_molecule

[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?

[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]

[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]

Pax5 is a protein_molecule, haploinsufficiency is an other_name, mammalian Pax genes is a DNA_family_or_group

34672_task1

Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please typing these entity words according to sentence: Pax5, haploinsufficiency, mammalian Pax genes Options: DNA_family_or_group, other_name, protein_molecule

[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?

[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]

[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]

Pax5, haploinsufficiency, mammalian Pax genes

34672_task2

Sentence: Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes? Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "B-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O" ]

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?

[ "Monoallelic", "expression", "of", "Pax5", ":", "a", "paradigm", "for", "the", "haploinsufficiency", "of", "mammalian", "Pax", "genes", "?" ]

[ "cell_type", "other_name", "(AND cell_type cell_type)", "DNA_family_or_group", "tissue", "DNA_domain_or_region", "", "protein_molecule" ]

beta2 adrenergic receptors is a protein, glutathione is a compound, Nrf2 is a protein

DS.d1298_task0

Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.

[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]

[ "protein", "compound" ]

beta2 adrenergic receptors is a protein, glutathione is a compound, Nrf2 is a protein

DS.d1298_task1

Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please typing these entity words according to sentence: beta2 adrenergic receptors, glutathione, Nrf2 Options: compound, protein

[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.

[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]

[ "protein", "compound" ]

beta2 adrenergic receptors, glutathione, Nrf2

DS.d1298_task2

Sentence: Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.

[ "Functional", "expression", "of", "beta2", "adrenergic", "receptors", "responsible", "for", "protection", "against", "oxidative", "stress", "through", "promotion", "of", "glutathione", "synthesis", "after", "Nrf2", "upregulation", "in", "undifferentiated", "mesenchymal", "C3H10T1/2", "stem", "cells", "." ]

[ "protein", "compound" ]

quercetin content is a compound, kaempferol is a compound, F3'H is a protein

DS.d154_task0

Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.

[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]

[ "compound", "protein" ]

quercetin content is a compound, kaempferol is a compound, F3'H is a protein

DS.d154_task1

Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please typing these entity words according to sentence: quercetin content, kaempferol, F3'H Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.

[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]

[ "compound", "protein" ]

quercetin content, kaempferol, F3'H

DS.d154_task2

Sentence: We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.

[ "We", "detected", "a", "marked", "decrease", "in", "target", "mRNA", ",", "an", "accumulation", "of", "short", "interfering", "RNAs", "(", "siRNAs", ")", ",", "and", "a", "decrease", "in", "quercetin", "content", "relative", "to", "kaempferol", "in", "leaf", "tissues", ",", "indicating", "that", "sequence", "-", "specific", "mRNA", "degradation", "of", "the", "F3'H", "gene", "was", "induced", "." ]

[ "compound", "protein" ]

Claudin-3 is a GENE-Y, claudin-4 is a GENE-Y, cisplatin is a CHEMICAL, copper and cisplatin influx transporter is a GENE-N, CTR1 is a GENE-Y

23053666_task0

Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL

[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]

Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.

[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Claudin-3 is a GENE-Y, claudin-4 is a GENE-Y, cisplatin is a CHEMICAL, copper and cisplatin influx transporter is a GENE-N, CTR1 is a GENE-Y

23053666_task1

Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please typing these entity words according to sentence: Claudin-3, claudin-4, cisplatin, copper and cisplatin influx transporter, CTR1 Options: GENE-N, GENE-Y, CHEMICAL

[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]

Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.

[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Claudin-3, claudin-4, cisplatin, copper and cisplatin influx transporter, CTR1

23053666_task2

Sentence: Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Instructions: please extract entity words from the input sentence

[ "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "B-GENE-Y", "O" ]

Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.

[ "Claudin-3", "and", "claudin-4", "regulate", "sensitivity", "to", "cisplatin", "by", "controlling", "expression", "of", "the", "copper", "and", "cisplatin", "influx", "transporter", "CTR1", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Komplikation is an umlsterm, vorderen Kreuzband is an umlsterm, Komplikation is an umlsterm, Verzoegerung is an umlsterm, Patientenselektion is an umlsterm, radiologischen is an umlsterm, Transplantatspannung is an umlsterm, Transplantatfixation is an umlsterm, Kniegelenks is an umlsterm, vorderen Kreuzband is an umlsterm

Arthroskopie.90120246.ger.abstr_task0

Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]

Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .

[ "Die", "Arthrofibrose", "ist", "eine", "bedeutende", "Komplikation", "nach", "Operationen", "am", "vorderen", "Kreuzband", ".", "Zur", "Prophylaxe", "dieser", "Komplikation", "dienen", "verschiedene", "prae-", ",", "intra-", "und", "postoperative", "Massnahmen", ".", "Praeoperative", "Massnahmen", "sind", "die", "Verzoegerung", "des", "Operationstermins", "bis", "zum", "Ende", "der", "inflammatorischen", "Phase", "nach", "dem", "Initialtrauma", ",", "ein", "praeoperatives", "Krankengymnastikprogramm", "sowie", "eine", "geeignete", "Patientenselektion", "und", "-aufklaerung", ".", "Intraoperative", "Massnahmen", "schliessen", "die", "exakte", "Plazierung", "der", "Bohrkanaele", "inklusive", "eines", "arthroskopischen", "und", "radiologischen", "Ausschlusses", "eines", "Transplantatimpingements", "ein", ".", "Weiterhin", "muss", "eine", "zu", "grosse", "Transplantatspannung", "zum", "Zeitpunkt", "der", "tibialen", "Transplantatfixation", "vermieden", "werden", ".", "Zu", "den", "postoperativen", "Massnahmen", "zaehlen", "die", "sofortige", "passive", "Strekkung", "des", "Kniegelenks", ",", "der", "fruehe", "Beginn", "eines", "Bewegungsprogramms", "und", "regelmaessige", "klinische", "Kontrollen", ".", "Aus", "der", "Erfahrung", "der", "eigenen", "Klinik", "kann", "bei", "Beruecksichtigung", "der", "genannten", "Massnahmen", "die", "Entwicklung", "einer", "Arthrofibrose", "nach", "Operationen", "am", "vorderen", "Kreuzband", "weitgehend", "vermieden", "werden", "." ]

[ "umlsterm" ]

Komplikation is an umlsterm, vorderen Kreuzband is an umlsterm, Komplikation is an umlsterm, Verzoegerung is an umlsterm, Patientenselektion is an umlsterm, radiologischen is an umlsterm, Transplantatspannung is an umlsterm, Transplantatfixation is an umlsterm, Kniegelenks is an umlsterm, vorderen Kreuzband is an umlsterm

Arthroskopie.90120246.ger.abstr_task1

Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please typing these entity words according to sentence: Komplikation, vorderen Kreuzband, Komplikation, Verzoegerung, Patientenselektion, radiologischen, Transplantatspannung, Transplantatfixation, Kniegelenks, vorderen Kreuzband Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]

Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .

[ "Die", "Arthrofibrose", "ist", "eine", "bedeutende", "Komplikation", "nach", "Operationen", "am", "vorderen", "Kreuzband", ".", "Zur", "Prophylaxe", "dieser", "Komplikation", "dienen", "verschiedene", "prae-", ",", "intra-", "und", "postoperative", "Massnahmen", ".", "Praeoperative", "Massnahmen", "sind", "die", "Verzoegerung", "des", "Operationstermins", "bis", "zum", "Ende", "der", "inflammatorischen", "Phase", "nach", "dem", "Initialtrauma", ",", "ein", "praeoperatives", "Krankengymnastikprogramm", "sowie", "eine", "geeignete", "Patientenselektion", "und", "-aufklaerung", ".", "Intraoperative", "Massnahmen", "schliessen", "die", "exakte", "Plazierung", "der", "Bohrkanaele", "inklusive", "eines", "arthroskopischen", "und", "radiologischen", "Ausschlusses", "eines", "Transplantatimpingements", "ein", ".", "Weiterhin", "muss", "eine", "zu", "grosse", "Transplantatspannung", "zum", "Zeitpunkt", "der", "tibialen", "Transplantatfixation", "vermieden", "werden", ".", "Zu", "den", "postoperativen", "Massnahmen", "zaehlen", "die", "sofortige", "passive", "Strekkung", "des", "Kniegelenks", ",", "der", "fruehe", "Beginn", "eines", "Bewegungsprogramms", "und", "regelmaessige", "klinische", "Kontrollen", ".", "Aus", "der", "Erfahrung", "der", "eigenen", "Klinik", "kann", "bei", "Beruecksichtigung", "der", "genannten", "Massnahmen", "die", "Entwicklung", "einer", "Arthrofibrose", "nach", "Operationen", "am", "vorderen", "Kreuzband", "weitgehend", "vermieden", "werden", "." ]

[ "umlsterm" ]

Komplikation, vorderen Kreuzband, Komplikation, Verzoegerung, Patientenselektion, radiologischen, Transplantatspannung, Transplantatfixation, Kniegelenks, vorderen Kreuzband

Arthroskopie.90120246.ger.abstr_task2

Sentence: Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden . Instructions: please extract entity words from the input sentence

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Die Arthrofibrose ist eine bedeutende Komplikation nach Operationen am vorderen Kreuzband . Zur Prophylaxe dieser Komplikation dienen verschiedene prae- , intra- und postoperative Massnahmen . Praeoperative Massnahmen sind die Verzoegerung des Operationstermins bis zum Ende der inflammatorischen Phase nach dem Initialtrauma , ein praeoperatives Krankengymnastikprogramm sowie eine geeignete Patientenselektion und -aufklaerung . Intraoperative Massnahmen schliessen die exakte Plazierung der Bohrkanaele inklusive eines arthroskopischen und radiologischen Ausschlusses eines Transplantatimpingements ein . Weiterhin muss eine zu grosse Transplantatspannung zum Zeitpunkt der tibialen Transplantatfixation vermieden werden . Zu den postoperativen Massnahmen zaehlen die sofortige passive Strekkung des Kniegelenks , der fruehe Beginn eines Bewegungsprogramms und regelmaessige klinische Kontrollen . Aus der Erfahrung der eigenen Klinik kann bei Beruecksichtigung der genannten Massnahmen die Entwicklung einer Arthrofibrose nach Operationen am vorderen Kreuzband weitgehend vermieden werden .

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[ "umlsterm" ]

Rehabilitation is an umlsterm, Praxis is an umlsterm, Fruehrehabilitation is an umlsterm, Akutkrankenhaus is an umlsterm, Rehabilitation is an umlsterm, Aktivbehandlung is an umlsterm, Rehabilitation is an umlsterm, Durchgangsarzt is an umlsterm, Rehabilitation is an umlsterm, Rehabilitation is an umlsterm, Hand is an umlsterm

Trauma+Berufskrankheit.0002s278.ger.abstr_task0

Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .

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[ "umlsterm" ]

Rehabilitation is an umlsterm, Praxis is an umlsterm, Fruehrehabilitation is an umlsterm, Akutkrankenhaus is an umlsterm, Rehabilitation is an umlsterm, Aktivbehandlung is an umlsterm, Rehabilitation is an umlsterm, Durchgangsarzt is an umlsterm, Rehabilitation is an umlsterm, Rehabilitation is an umlsterm, Hand is an umlsterm

Trauma+Berufskrankheit.0002s278.ger.abstr_task1

Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please typing these entity words according to sentence: Rehabilitation, Praxis, Fruehrehabilitation, Akutkrankenhaus, Rehabilitation, Aktivbehandlung, Rehabilitation, Durchgangsarzt, Rehabilitation, Rehabilitation, Hand Options: umlsterm

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Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .

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[ "umlsterm" ]

Rehabilitation, Praxis, Fruehrehabilitation, Akutkrankenhaus, Rehabilitation, Aktivbehandlung, Rehabilitation, Durchgangsarzt, Rehabilitation, Rehabilitation, Hand

Trauma+Berufskrankheit.0002s278.ger.abstr_task2

Sentence: Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann . Instructions: please extract entity words from the input sentence

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Die Gesetze sehen eine fruehzeitige Vernetzung der umfassenden Rehabilitation vor . Diese Vorschriften werden in der Praxis nicht beachtet , was zur Folge hat , dass es fuer die Versicherten zu schlechten Ergebnissen kommt , die unnoetige Folgekosten von 50.000 DM und mehr verursachen , welche eingespart werden koennten . Das 1. " Rehabilitationsloch " ist , dass es an einer Fruehrehabilitation im Akutkrankenhaus fehlt , das 2. , dass eine Rehabilitation nach Aktivbehandlung gar nicht , zu spaet oder nicht umfassend stattfindet . Das 3. " Rehabilitationsloch " ist dadurch charakterisiert , dass die medizinische Rehabilitation nicht berufsbezogen erfolgt , was dazu fuehrt , dass ein Beharrungszustand der Arbeitsunfaehigkeit ueber Monate hinweg eintritt . Die Rehabilitationsloecher " " koennten im Einzelfall dadurch vermieden werden , dass der Sachbearbeiter sich durch einen Facharzt fuer physikalische und Rehabilitationsmedizin beraten laesst und das Verfahren entsprechend steuert . Zukuenftig ist der Durchgangsarzt zum Thema Medizinische Rehabilitation aus- und weiterzubilden , damit er dann die medizinische Rehabilitation aus einer Hand steuern kann .

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[ "umlsterm" ]

K+ channels is a protein_family_or_group, Ca2 + signaling is an other_name, gene expression is an other_name, T lymphocytes is a cell_type

72968_task0

Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, other_name

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.

[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]

[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]

K+ channels is a protein_family_or_group, Ca2 + signaling is an other_name, gene expression is an other_name, T lymphocytes is a cell_type

72968_task1

Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please typing these entity words according to sentence: K+ channels, Ca2 + signaling, gene expression, T lymphocytes Options: cell_type, protein_family_or_group, other_name

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.

[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]

[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]

K+ channels, Ca2 + signaling, gene expression, T lymphocytes

72968_task2

Sentence: A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-other_name", "I-other_name", "I-other_name", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O" ]

A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.

[ "A", "nongenomic", "mechanism", "for", "progesterone", "-", "mediated", "immunosuppression", ":", "inhibition", "of", "K+", "channels", ",", "Ca2", "+", "signaling", ",", "and", "gene", "expression", "in", "T", "lymphocytes", "." ]

[ "other_name", "(AND protein_family_or_group protein_family_or_group)", "protein_family_or_group", "protein_subunit", "cell_type", "", "lipid", "cell_line", "other_organic_compound", "protein_molecule", "atom" ]

vein is an umlsterm, limb is an umlsterm, ischemia is an umlsterm, All is an umlsterm, patients is an umlsterm, program is an umlsterm, patients is an umlsterm, patients is an umlsterm, diabetes is an umlsterm, patients is an umlsterm, diabetes mellitus is an umlsterm, sex is an umlsterm, age is an umlsterm, limb is an umlsterm, limb is an umlsterm, limb is an umlsterm, amputations is an umlsterm, amputation is an umlsterm, foot is an umlsterm, infection is an umlsterm

Gefaesschirurgie.90040040.eng.abstr_task0

Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .

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[ "umlsterm" ]

vein is an umlsterm, limb is an umlsterm, ischemia is an umlsterm, All is an umlsterm, patients is an umlsterm, program is an umlsterm, patients is an umlsterm, patients is an umlsterm, diabetes is an umlsterm, patients is an umlsterm, diabetes mellitus is an umlsterm, sex is an umlsterm, age is an umlsterm, limb is an umlsterm, limb is an umlsterm, limb is an umlsterm, amputations is an umlsterm, amputation is an umlsterm, foot is an umlsterm, infection is an umlsterm

Gefaesschirurgie.90040040.eng.abstr_task1

Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please typing these entity words according to sentence: vein, limb, ischemia, All, patients, program, patients, patients, diabetes, patients, diabetes mellitus, sex, age, limb, limb, limb, amputations, amputation, foot, infection Options: umlsterm

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In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .

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[ "umlsterm" ]

vein, limb, ischemia, All, patients, program, patients, patients, diabetes, patients, diabetes mellitus, sex, age, limb, limb, limb, amputations, amputation, foot, infection

Gefaesschirurgie.90040040.eng.abstr_task2

Sentence: In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection . Instructions: please extract entity words from the input sentence

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In the last 7 years we have performed 220 infrainguinal vein bypasses associated with critical limb ischemia . All patients were prospectively controlled in a follow-up program 3 - 72 months postoperatively . The patients were divided into two groups : patients with diabetes mellitus ( 35% , group 1 ) and patients without diabetes mellitus ( 65% , group 2 ) . There was no difference in sex , age or localization of distal anastomosis ( supra- or infragenicular ) between the two groups . The primary and the primary-assisted patency rates were not statistically different after 60 months . There was a significant difference in limb salvage . The limb salvage of group 1 was 75% after 60 months , while the limb salvage of group 2 was 95% ( P = 0.0045 ) . The rate of major amputations was significantly higher in group 1 ( 15.6% ) than in group 2 ( 4.9% , P = 0.007 ) . The indication for amputation was persistent foot infection .

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[ "umlsterm" ]

Healthy is a Condition, male is a Person, female is a Person, adolescents is a Person, age is a Person, 12 to 17 years is a Value, at Screening is a Temporal, body mass index ( BMI ) is a Measurement, greater than or equal to the United States - weighted mean of the 95th percentile is a Value, based on age and sex is a Scope, body weight is a Measurement, greater than 60 kilograms ( kg ) is a Value, HbA1c is a Measurement, = 6.5 % is a Value, fasting plasma glucose ( FPG ) is a Measurement, = 126 mg / dL is a Value, 7.0 mmol / L is a Value, not is a Negation, planning to move away is a Observation, for the duration of the study is a Temporal, able and willing to comply is a Scope, standardized , reduced calorie diet and an age appropriate , increased physical activity program is a Scope, stable health is a Observation, Able and willing to personally comply is a Scope, caregivers or guardians is a Scope

NCT03338296_inc_task0

Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Observation, Negation, Scope, Measurement

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Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians

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[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]

Healthy is a Condition, male is a Person, female is a Person, adolescents is a Person, age is a Person, 12 to 17 years is a Value, at Screening is a Temporal, body mass index ( BMI ) is a Measurement, greater than or equal to the United States - weighted mean of the 95th percentile is a Value, based on age and sex is a Scope, body weight is a Measurement, greater than 60 kilograms ( kg ) is a Value, HbA1c is a Measurement, = 6.5 % is a Value, fasting plasma glucose ( FPG ) is a Measurement, = 126 mg / dL is a Value, 7.0 mmol / L is a Value, not is a Negation, planning to move away is a Observation, for the duration of the study is a Temporal, able and willing to comply is a Scope, standardized , reduced calorie diet and an age appropriate , increased physical activity program is a Scope, stable health is a Observation, Able and willing to personally comply is a Scope, caregivers or guardians is a Scope

NCT03338296_inc_task1

Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please typing these entity words according to sentence: Healthy, male, female, adolescents, age, 12 to 17 years, at Screening, body mass index ( BMI ), greater than or equal to the United States - weighted mean of the 95th percentile, based on age and sex, body weight, greater than 60 kilograms ( kg ), HbA1c, = 6.5 %, fasting plasma glucose ( FPG ), = 126 mg / dL, 7.0 mmol / L, not, planning to move away, for the duration of the study, able and willing to comply, standardized , reduced calorie diet and an age appropriate , increased physical activity program, stable health, Able and willing to personally comply, caregivers or guardians Options: Temporal, Condition, Value, Person, Observation, Negation, Scope, Measurement

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Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians

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[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]

Healthy, male, female, adolescents, age, 12 to 17 years, at Screening, body mass index ( BMI ), greater than or equal to the United States - weighted mean of the 95th percentile, based on age and sex, body weight, greater than 60 kilograms ( kg ), HbA1c, = 6.5 %, fasting plasma glucose ( FPG ), = 126 mg / dL, 7.0 mmol / L, not, planning to move away, for the duration of the study, able and willing to comply, standardized , reduced calorie diet and an age appropriate , increased physical activity program, stable health, Able and willing to personally comply, caregivers or guardians

NCT03338296_inc_task2

Sentence: Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians Instructions: please extract entity words from the input sentence

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Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM. HbA1c =6.5% fasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L) Participants and their families not planning to move away from the area for the duration of the study Participants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program Participants considered in stable health in the opinion of the investigator Able and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol Able and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians

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[ "Scope", "Value", "Observation", "Temporal", "Measurement", "Qualifier", "Person", "Reference_point", "Condition", "Negation" ]

Infektionsprophylaxe is an umlsterm, hygienegerechtem is an umlsterm, Verhalten is an umlsterm, Boden is an umlsterm, Zeitplanung is an umlsterm, Technik is an umlsterm, Verhaltens is an umlsterm, Operationstechnik is an umlsterm, Hygiene is an umlsterm, Hand is an umlsterm, Infektionsstatistik is an umlsterm, Personals is an umlsterm, Patienten is an umlsterm, Infektionen is an umlsterm

DerChirurg.60671123.ger.abstr_task0

Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .

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[ "umlsterm" ]

Infektionsprophylaxe is an umlsterm, hygienegerechtem is an umlsterm, Verhalten is an umlsterm, Boden is an umlsterm, Zeitplanung is an umlsterm, Technik is an umlsterm, Verhaltens is an umlsterm, Operationstechnik is an umlsterm, Hygiene is an umlsterm, Hand is an umlsterm, Infektionsstatistik is an umlsterm, Personals is an umlsterm, Patienten is an umlsterm, Infektionen is an umlsterm

DerChirurg.60671123.ger.abstr_task1

Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please typing these entity words according to sentence: Infektionsprophylaxe, hygienegerechtem, Verhalten, Boden, Zeitplanung, Technik, Verhaltens, Operationstechnik, Hygiene, Hand, Infektionsstatistik, Personals, Patienten, Infektionen Options: umlsterm

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Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .

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[ "umlsterm" ]

Infektionsprophylaxe, hygienegerechtem, Verhalten, Boden, Zeitplanung, Technik, Verhaltens, Operationstechnik, Hygiene, Hand, Infektionsstatistik, Personals, Patienten, Infektionen

DerChirurg.60671123.ger.abstr_task2

Sentence: Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Perioperative Infektionsprophylaxe stellt ein Zusammenspiel aus technischem Equipment , gutem Operieren und hygienegerechtem Verhalten dar . Der Boden , auf dem dies waechst , ist ein ueberschaubarer , gut organisierter Betrieb mit bekannten , allgemein eingeuebten Funktionsablaeufen und mit einer soliden , einhaltbaren Zeitplanung . Die wichtigste Technik zur Ueberwachung und Verbesserung des Verhaltens ( hinsichtlich Operationstechnik und Hygiene ) ist das Vorbild , das Anwesend-sein ( " Inter-esse " ) . Hierbei werden gleichzeitig Detailfehler erkannt . Darueber hinaus dient zur Erfolgskontrolle ( bzw. Misserfolgskontrolle ) eine langfristig ehrlich und in einer Hand gefuehrte Infektionsstatistik , welche sich vorrangig mit den intern beeinflussbaren Faktoren zu beschaeftigen hat und welche zur externen Praesentation in der Regel nicht taugt . Dem Schutz des Personals kommt der selbe hohe Stellenwert zu wie dem Schutz der Patienten vor Infektionen . Ob antibiotische routinemaessige Prophylaxemassnahmen in der Unfallchirurgie unter heutigen Bedingungen eine Berechtigung haben , ist im Augenblick theoretisch nicht geklaert .

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[ "umlsterm" ]

development is an umlsterm, septorhinoplasty is an umlsterm, developments is an umlsterm, surgery is an umlsterm, open is an umlsterm, septorhinoplasty is an umlsterm, surgery is an umlsterm

HNO.00480562.eng.abstr_task0

Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .

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[ "umlsterm" ]

development is an umlsterm, septorhinoplasty is an umlsterm, developments is an umlsterm, surgery is an umlsterm, open is an umlsterm, septorhinoplasty is an umlsterm, surgery is an umlsterm

HNO.00480562.eng.abstr_task1

Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please typing these entity words according to sentence: development, septorhinoplasty, developments, surgery, open, septorhinoplasty, surgery Options: umlsterm

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Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .

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[ "umlsterm" ]

development, septorhinoplasty, developments, surgery, open, septorhinoplasty, surgery

HNO.00480562.eng.abstr_task2

Sentence: Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended . Instructions: please extract entity words from the input sentence

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Looking back at 150 years of the development of septorhinoplasty - 50 of which I have experienced myself - one can conclude that recent developments go back to the nineteenth century . In the era of " minimal invasive surgery " the " open approach " to septorhinoplasty should no longer be indicated . The sublabial approach in the sense of minimal invasive surgery is recommended .

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[ "umlsterm" ]

sexuell uebertragbaren Krankheiten is an umlsterm, Stadt is an umlsterm, Ruhr - Universitaet is an umlsterm, Beratung is an umlsterm, Geschlechtskranken is an umlsterm, anonyme is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Deutschland is an umlsterm, Frauen is an umlsterm, Kondome is an umlsterm, Kondome is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Gesundheitsbewusstsein is an umlsterm, Risikobereitschaft is an umlsterm, Frauen is an umlsterm

DerHautarzt.70480166.ger.abstr_task0

Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .

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[ "umlsterm" ]

sexuell uebertragbaren Krankheiten is an umlsterm, Stadt is an umlsterm, Ruhr - Universitaet is an umlsterm, Beratung is an umlsterm, Geschlechtskranken is an umlsterm, anonyme is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Deutschland is an umlsterm, Frauen is an umlsterm, Kondome is an umlsterm, Kondome is an umlsterm, Frauen is an umlsterm, Frauen is an umlsterm, Gesundheitsbewusstsein is an umlsterm, Risikobereitschaft is an umlsterm, Frauen is an umlsterm

DerHautarzt.70480166.ger.abstr_task1

Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please typing these entity words according to sentence: sexuell uebertragbaren Krankheiten, Stadt, Ruhr - Universitaet, Beratung, Geschlechtskranken, anonyme, Frauen, Frauen, Deutschland, Frauen, Kondome, Kondome, Frauen, Frauen, Gesundheitsbewusstsein, Risikobereitschaft, Frauen Options: umlsterm

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Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .

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[ "umlsterm" ]

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DerHautarzt.70480166.ger.abstr_task2

Sentence: Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden . Instructions: please extract entity words from the input sentence

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Regelmaessige Untersuchungen von Prostituierten sind eine Moeglichkeit der Praevention von sexuell uebertragbaren Krankheiten ( STD ) in dieser Risikogruppe . Seit dem 1.4.1988 wird im Gesundheitsamt der Stadt Bochum in Kooperation mit der Dermatologischen Klinik der Ruhr-Universitaet Bochum eine Sprechstunde zur Beratung und Untersuchung von Geschlechtskranken angeboten . Ziel der vorliegenden Studie war es , die Effektivitaet und Akzeptanz dieser Einrichtung zu ueberpruefen . Aus diesem Grund wurden anonyme Frageboegen ausgelegt , die von 80 Frauen beantwortet wurden . Der Altersdurchschnitt lag bei 31,4 Jahren . 67 Frauen stammten aus Deutschland . 78 der 80 Frauen benutzten immer Kondome , 71 glaubten an einen Gesundheitsschutz durch Kondome . 3 der 80 Frauen gaben an , in den letzten 12 Monaten an einer STD erkrankt zu sein . 75 der 80 Frauen empfanden die Untersuchung ausdruecklich nicht als diskriminierend ; 71 beurteilten die Qualitaet der Untersuchungen als gut . Aus diesen Ergebnissen laesst sich ableiten , dass die von Dermatologen im Gesundheitsamt durchgefuehrten regelmaessigen , obligatorischen Untersuchungen zu einem hohen Gesundheitsbewusstsein mit geringer Risikobereitschaft gefuehrt haben und von den Frauen gut akzeptiert werden .

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[ "umlsterm" ]

Thrombozytenwerte is an umlsterm, weisser is an umlsterm, Heparin - induzierter is an umlsterm, Thrombozytopenie is an umlsterm, Heparin - induzierten is an umlsterm, Heparin - Therapie is an umlsterm, Phenprocoumon is an umlsterm, Revisionseingriffs is an umlsterm, Hirudin is an umlsterm, Diagnosestellung is an umlsterm, Therapie is an umlsterm

Gefaesschirurgie.00050125.ger.abstr_task0

Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .

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[ "umlsterm" ]

Thrombozytenwerte is an umlsterm, weisser is an umlsterm, Heparin - induzierter is an umlsterm, Thrombozytopenie is an umlsterm, Heparin - induzierten is an umlsterm, Heparin - Therapie is an umlsterm, Phenprocoumon is an umlsterm, Revisionseingriffs is an umlsterm, Hirudin is an umlsterm, Diagnosestellung is an umlsterm, Therapie is an umlsterm

Gefaesschirurgie.00050125.ger.abstr_task1

Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please typing these entity words according to sentence: Thrombozytenwerte, weisser, Heparin - induzierter, Thrombozytopenie, Heparin - induzierten, Heparin - Therapie, Phenprocoumon, Revisionseingriffs, Hirudin, Diagnosestellung, Therapie Options: umlsterm

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Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .

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[ "umlsterm" ]

Thrombozytenwerte, weisser, Heparin - induzierter, Thrombozytopenie, Heparin - induzierten, Heparin - Therapie, Phenprocoumon, Revisionseingriffs, Hirudin, Diagnosestellung, Therapie

Gefaesschirurgie.00050125.ger.abstr_task2

Sentence: Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert . Instructions: please extract entity words from the input sentence

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Zusammenfassung Es wird ueber den Verlauf bei einer 71jaehrigen Patientin berichtet , bei der es nach Anlage eines femoropoplitealen Bypasses sowie mehrfachen Revisions-operationen zu fruehen Bypassverschluessen und peripheren Gefaessokklusionen kam . Ein zusaetzli- cher Abfall der Thrombozytenwerte unter 50% der Ausgangswerte in Zusammenhang mit dem intraoperativem Befund " weisser Thromben " lenkte den Verdacht auf ein White-clot-Syndrom ' bei Heparin-induzierter Thrombozytopenie Typ II , welche sich im Heparin-induzierten Plaettchenaggregationstest ( HIPA ) bestaetigte . Nach Umsetzen der Heparin-Therapie auf Danaparoid-Na ( Orgaran ) kam es zu einem weiteren Abfall derThrombozyten . Der klini-sche Verdacht auf Kreuzreaktivitaet zu Danaparoid-Na wurde im HIPA-Test verifiziert . Im weiterem Verlauf erfolgte zunaechst die Antikoagula- tion mit Phenprocoumon ( Marcumar ) und dann im Rahmen eines Revisionseingriffs mit rekombinantem Hirudin ( Refludan , Fa. Hoechst ) . Die Probleme bezueglich rechtzeitiger Diagnosestellung und antikoagu-lativer Therapie bei Kreuzreaktivitaet mit Orgaran werden diskutiert .

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[ "umlsterm" ]

Venensystems is an umlsterm, Diagnostik is an umlsterm, Therapiekontrolle is an umlsterm, Kompressionssonographie is an umlsterm, Diagnostik is an umlsterm, tiefen Venenthrombose is an umlsterm, Thrombosen is an umlsterm, Syndrom is an umlsterm, Phlebographie is an umlsterm, Venenerkrankungen is an umlsterm, Halses is an umlsterm, Arme is an umlsterm, Beine is an umlsterm, Patienten is an umlsterm, Intensivstationen is an umlsterm, Beurteilung is an umlsterm, Dialyseshunts is an umlsterm, Diagnostik is an umlsterm, Ultraschalluntersuchungen is an umlsterm, Venenerkrankungen is an umlsterm

DerRadiologe.80380560.ger.abstr_task0

Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .

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[ "umlsterm" ]

Venensystems is an umlsterm, Diagnostik is an umlsterm, Therapiekontrolle is an umlsterm, Kompressionssonographie is an umlsterm, Diagnostik is an umlsterm, tiefen Venenthrombose is an umlsterm, Thrombosen is an umlsterm, Syndrom is an umlsterm, Phlebographie is an umlsterm, Venenerkrankungen is an umlsterm, Halses is an umlsterm, Arme is an umlsterm, Beine is an umlsterm, Patienten is an umlsterm, Intensivstationen is an umlsterm, Beurteilung is an umlsterm, Dialyseshunts is an umlsterm, Diagnostik is an umlsterm, Ultraschalluntersuchungen is an umlsterm, Venenerkrankungen is an umlsterm

DerRadiologe.80380560.ger.abstr_task1

Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please typing these entity words according to sentence: Venensystems, Diagnostik, Therapiekontrolle, Kompressionssonographie, Diagnostik, tiefen Venenthrombose, Thrombosen, Syndrom, Phlebographie, Venenerkrankungen, Halses, Arme, Beine, Patienten, Intensivstationen, Beurteilung, Dialyseshunts, Diagnostik, Ultraschalluntersuchungen, Venenerkrankungen Options: umlsterm

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Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .

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[ "umlsterm" ]

Venensystems, Diagnostik, Therapiekontrolle, Kompressionssonographie, Diagnostik, tiefen Venenthrombose, Thrombosen, Syndrom, Phlebographie, Venenerkrankungen, Halses, Arme, Beine, Patienten, Intensivstationen, Beurteilung, Dialyseshunts, Diagnostik, Ultraschalluntersuchungen, Venenerkrankungen

DerRadiologe.80380560.ger.abstr_task2

Sentence: Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern . Instructions: please extract entity words from the input sentence

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Die Haeufigkeit akuter und chronischer Erkrankungen des Venensystems erfordert fuer die Diagnostik und Therapiekontrolle zuverlaessige nichtinvasive und moeglichst kostenguenstige Untersuchungsverfahren . , Bereits Mitte der 80er Jahre hat sich die Kompressionssonographie als wertvolle Bereicherung bei der Diagnostik der tiefen Venenthrombose etabliert . Dopplersonographische Untersuchungsmethoden haben insbesondere seit Einfuehrung der Farbduplexsonographie einen hohen Stellenwert erreicht . Bei Thrombosen , beim postthrombotischen Syndrom und bei der primaeren Varikosis verdraengt die Farbduplexsonographie zunehmend die Phlebographie . Venenerkrankungen des Halses , der Arme und Beine koennen heute mittels Farbduplexsonographie zuverlaessig erkannt werden . Neuere Einsatzgebiete fuer die Duplex- bzw. Farbduplexsonographie schliessen das venoese Gefaesssystem bei Patienten auf Intensivstationen , die Beurteilung von transplantierten Organen und die Darstellung der Stroemungsverhaeltnisse in Dialyseshunts ein . Angesichts der Kostenentwicklung bei der bildgebenden Diagnostik , an der die drastische Zunahme der Ultraschalluntersuchungen einen grossen Anteil hat , ist allerdings eine kritische Indikationsstellung zum Einsatz der Doppler- und Duplexsonographieverfahren auch bei der Untersuchung von Venenerkrankungen zu fordern .

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[ "umlsterm" ]

Bacterial peptidoglycan is a carbohydrate, CD14-dependent activation is an other_name, transcription factors is a protein_family_or_group, CREB / ATF is a protein_molecule, AP-1 is a protein_molecule

38927_task0

Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: carbohydrate, protein_family_or_group, protein_molecule, other_name

[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]

Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.

[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]

[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]

Bacterial peptidoglycan is a carbohydrate, CD14-dependent activation is an other_name, transcription factors is a protein_family_or_group, CREB / ATF is a protein_molecule, AP-1 is a protein_molecule

38927_task1

Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please typing these entity words according to sentence: Bacterial peptidoglycan, CD14-dependent activation, transcription factors, CREB / ATF, AP-1 Options: carbohydrate, protein_family_or_group, protein_molecule, other_name

[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]

Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.

[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]

[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]

Bacterial peptidoglycan, CD14-dependent activation, transcription factors, CREB / ATF, AP-1

38927_task2

Sentence: Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1. Instructions: please extract entity words from the input sentence

[ "B-carbohydrate", "I-carbohydrate", "O", "B-other_name", "I-other_name", "O", "B-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O" ]

Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.

[ "Bacterial", "peptidoglycan", "induces", "CD14-dependent", "activation", "of", "transcription", "factors", "CREB", "/", "ATF", "and", "AP-1", "." ]

[ "cell_line", "other_name", "protein_family_or_group", "carbohydrate", "mono_cell", "DNA_molecule", "lipid", "other_organic_compound", "DNA_family_or_group", "cell_type", "protein_molecule", "DNA_N/A" ]

melanoma is a Participant_Condition, behavioral intervention project is a Intervention_Educational, report is a Outcome_Other, individual and family - level factors is a Outcome_Mental, participation is a Outcome_Mental, web - based communication and support intervention is a Intervention_Educational, three family members per family is a Participant_Sample-size, 18 or younger is a Participant_Age, 1380 is a Participant_Sample-size, 313 is a Participant_Sample-size, refusal is a Outcome_Other, higher educational attainment . is a Outcome_Mental, diagnosed more recently is a Outcome_Physical, parent was partnered is a Outcome_Other, parent lived in the same city as the case is a Outcome_Mental

52244_task0

Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Sample-size", "Outcome_Physical", "Outcome_Other", "Participant_Age", "Participant_Condition" ]

melanoma is a Participant_Condition, behavioral intervention project is a Intervention_Educational, report is a Outcome_Other, individual and family - level factors is a Outcome_Mental, participation is a Outcome_Mental, web - based communication and support intervention is a Intervention_Educational, three family members per family is a Participant_Sample-size, 18 or younger is a Participant_Age, 1380 is a Participant_Sample-size, 313 is a Participant_Sample-size, refusal is a Outcome_Other, higher educational attainment . is a Outcome_Mental, diagnosed more recently is a Outcome_Physical, parent was partnered is a Outcome_Other, parent lived in the same city as the case is a Outcome_Mental

52244_task1

Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please typing these entity words according to sentence: melanoma, behavioral intervention project, report, individual and family - level factors, participation, web - based communication and support intervention, three family members per family, 18 or younger, 1380, 313, refusal, higher educational attainment ., diagnosed more recently, parent was partnered, parent lived in the same city as the case Options: Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Sample-size", "Outcome_Physical", "Outcome_Other", "Participant_Age", "Participant_Condition" ]

melanoma, behavioral intervention project, report, individual and family - level factors, participation, web - based communication and support intervention, three family members per family, 18 or younger, 1380, 313, refusal, higher educational attainment ., diagnosed more recently, parent was partnered, parent lived in the same city as the case

52244_task2

Sentence: Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment . Instructions: please extract entity words from the input sentence

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Predictors of recruited melanoma families into a behavioral intervention project . BACKGROUND Examination of families represents an important priority in health research . In this paper we report on individual and family-level factors associated with enrollment in a cancer prevention research project . We approached families affected by melanoma for possible participation in a randomized controlled trial of a web-based communication and support intervention . METHODS We recruited three family members per family for assessment - the melanoma case , a first-degree relative ( FDR ) , and a relative who is a parent of a child age 18 or younger . Recruitment involved three steps : requesting the physician 's consent to approach the melanoma case , approaching the case to request their participation and family contact information , and they approaching the FDRs and parents . RESULTS Of the 1380 families approached , 313 were enrolled , 263 were excluded because we could not find or contact a family member ( FDR or parent ) , 331 did not have eligible family members , and 473 refused . The most frequently noted reason for refusal was being too busy or having no time . The primary predictors of participation for cases ( OR=1.6 ; CI=1.01-2.51 ) and FDRs ( OR=2.15 ; CI=1.11-4.13 ) included higher educational attainment . FDRs were more likely to enroll if they were female ( OR=1.77 ; CI=1.1-.85 ) and parents were more likely to enroll if the case had been diagnosed more recently ( OR=3.3 ; CI=1.9-5.93 ) , if the parent was partnered ( OR=4.37 ; CI=1.86-10.26 ) , and if the parent lived in the same city as the case ( OR=2.88 ; CI=1.08-7.68 ) . CONCLUSIONS The results can provide information on potential directions for future family recruitment .

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[ "Intervention_Educational", "Outcome_Mental", "Participant_Sample-size", "Outcome_Physical", "Outcome_Other", "Participant_Age", "Participant_Condition" ]

Pregnant is a Condition, American Society of Anesthesiologists risk classification is a Measurement, I and II is a Value, Age is a Person, > 18 years is a Value, Non - laboring is a Value, elective is a Qualifier, cesarean sections is a Procedure

NCT02872935_inc_task0

Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Procedure, Measurement

[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]

Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections

[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]

[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]

Pregnant is a Condition, American Society of Anesthesiologists risk classification is a Measurement, I and II is a Value, Age is a Person, > 18 years is a Value, Non - laboring is a Value, elective is a Qualifier, cesarean sections is a Procedure

NCT02872935_inc_task1

Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please typing these entity words according to sentence: Pregnant, American Society of Anesthesiologists risk classification, I and II, Age, > 18 years, Non - laboring, elective, cesarean sections Options: Condition, Qualifier, Value, Person, Procedure, Measurement

[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]

Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections

[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]

[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]

Pregnant, American Society of Anesthesiologists risk classification, I and II, Age, > 18 years, Non - laboring, elective, cesarean sections

NCT02872935_inc_task2

Sentence: Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections Instructions: please extract entity words from the input sentence

[ "B-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Person", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O" ]

Pregnant American Society of Anesthesiologists risk classification I and II Age > 18 years Non-laboring Patients with elective cesarean sections

[ "Pregnant", "\n", "American", "Society", "of", "Anesthesiologists", "risk", "classification", "I", "and", "II", "\n", "Age", ">", "18", "years", "\n", "Non", "-", "laboring", "\n", "Patients", "with", "elective", "cesarean", "sections", "\n" ]

[ "Measurement", "Procedure", "Value", "Condition", "Qualifier", "Person" ]

digoxin is a DRUG, amiodarone is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, amiodarone is a DRUG, digoxin is a DRUG, Digoxin is a DRUG, Digoxin is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, digoxin is a DRUG

3964797_task0

Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DRUG

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Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.

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[ "DRUG" ]

digoxin is a DRUG, amiodarone is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, amiodarone is a DRUG, digoxin is a DRUG, Digoxin is a DRUG, Digoxin is a DRUG, Amiodarone is a DRUG, digoxin is a DRUG, digoxin is a DRUG, amiodarone is a DRUG, digoxin is a DRUG

3964797_task1

Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please typing these entity words according to sentence: digoxin, amiodarone, Amiodarone, digoxin, digoxin, digoxin, amiodarone, amiodarone, digoxin, Digoxin, Digoxin, Amiodarone, digoxin, digoxin, amiodarone, digoxin Options: DRUG

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Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.

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[ "DRUG" ]

digoxin, amiodarone, Amiodarone, digoxin, digoxin, digoxin, amiodarone, amiodarone, digoxin, Digoxin, Digoxin, Amiodarone, digoxin, digoxin, amiodarone, digoxin

3964797_task2

Sentence: Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically. Instructions: please extract entity words from the input sentence

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Pharmacokinetic evaluation of the digoxin-amiodarone interaction. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic variables for digoxin were determined after a 1.0 mg intravenous dose of digoxin in each subject, before and after oral amiodarone, 400 mg daily for 3 weeks. During amiodarone administration, systemic clearance of digoxin was reduced from 234 +/- 72 ml/min (mean +/- standard deviation) to 172 +/- 33 ml/min (p less than 0.01). This was due to reductions in both renal clearance (from 105 +/- 39 to 84 +/- 15 ml/min) (p less than 0.05) and nonrenal clearance (from 130 +/- 38 to 88 +/- 20 ml/min) (p less than 0.01). Digoxin half-life of elimination was prolonged from 34 +/- 13 to 40 +/- 16 hours (p less than 0.05). Digoxin volume of distribution was not significantly changed. Amiodarone caused a three- to fivefold increase in serum reverse triiodothyronine levels, but changes in thyroid function were not quantitatively related to the changes in digoxin pharmacokinetics. These alterations in digoxin pharmacokinetics produced by amiodarone explain the increase in serum digoxin level that has been observed when this drug combination has been used clinically.

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[ "DRUG" ]

Patienten is an umlsterm, Patientengut is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Schmerzmittel is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Selbst is an umlsterm

DerChirurg.70680613.ger.abstr_task0

Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .

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[ "umlsterm" ]

Patienten is an umlsterm, Patientengut is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Schmerzmittel is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Risiko is an umlsterm, Selbst is an umlsterm

DerChirurg.70680613.ger.abstr_task1

Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please typing these entity words according to sentence: Patienten, Patientengut, Patienten, Komplikationen, Patienten, Schmerzmittel, Patienten, Patienten, Patienten, Risiko, Selbst Options: umlsterm

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Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .

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[ "umlsterm" ]

Patienten, Patientengut, Patienten, Komplikationen, Patienten, Schmerzmittel, Patienten, Patienten, Patienten, Risiko, Selbst

DerChirurg.70680613.ger.abstr_task2

Sentence: Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem . Instructions: please extract entity words from the input sentence

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Zusammenfassung . In einer prospektiven Beobachtungsstudie wurden 140 Patienten erfasst , die rein ambulant laparoskopisch cholecystektomiert wurden . Das Patientengut entspricht im wesentlichen den Veroeffentlichungen stationaer operierter Patienten . Es gab keine relevanten intra- und postoperativen Komplikationen . Postoperativ brauchten die Patienten weniger Schmerzmittel , erholten sich schneller und waren schneller wieder arbeitsfaehig als Patienten in vergleichbaren Veroeffentlichungen stationaer operierter Patienten . Die ambulante laparoskopische Cholecystektomie ist eine gute Alternative fuer Patienten mit geringem oder mittlerem Risiko . Selbst bei verbesserter Ertragssituation fuer die Operationseinrichtung eroeffnet sie ausserdem Einsparpotentiale im Gesundheitssystem .

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saline solution load test is a Intervention_Educational, appropriate volume is a Outcome_Other, needle location is a Outcome_Other, Fifty - six is a Participant_Sample-size, patients is a Participant_Sample-size, scheduled for knee arthroscopy is a Participant_Condition, single stab incision with use of a number-11 blade is a Intervention_Physical, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle is a Intervention_Pharmacological, thirty - one is a Participant_Sample-size, female is a Participant_Sex, patients and twenty - five is a Participant_Sample-size, average age of fifty years is a Participant_Age, average body mass index is a Outcome_Physical, diagnose 50 % of the arthrotomies is a Outcome_Other, volumes that were needed in order to effectively diagnose is a Outcome_Other, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations is a Outcome_Physical, significantly less fluid is a Outcome_Other

38515_task0

Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other

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Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .

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saline solution load test is a Intervention_Educational, appropriate volume is a Outcome_Other, needle location is a Outcome_Other, Fifty - six is a Participant_Sample-size, patients is a Participant_Sample-size, scheduled for knee arthroscopy is a Participant_Condition, single stab incision with use of a number-11 blade is a Intervention_Physical, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle is a Intervention_Pharmacological, thirty - one is a Participant_Sample-size, female is a Participant_Sex, patients and twenty - five is a Participant_Sample-size, average age of fifty years is a Participant_Age, average body mass index is a Outcome_Physical, diagnose 50 % of the arthrotomies is a Outcome_Other, volumes that were needed in order to effectively diagnose is a Outcome_Other, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations is a Outcome_Physical, significantly less fluid is a Outcome_Other

38515_task1

Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please typing these entity words according to sentence: saline solution load test, appropriate volume, needle location, Fifty - six, patients, scheduled for knee arthroscopy, single stab incision with use of a number-11 blade, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle, thirty - one, female, patients and twenty - five, average age of fifty years, average body mass index, diagnose 50 % of the arthrotomies, volumes that were needed in order to effectively diagnose, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations, significantly less fluid Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other

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Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .

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saline solution load test, appropriate volume, needle location, Fifty - six, patients, scheduled for knee arthroscopy, single stab incision with use of a number-11 blade, injection of normal saline solution at a rate of 5 mL / sec through an 18-gauge needle, thirty - one, female, patients and twenty - five, average age of fifty years, average body mass index, diagnose 50 % of the arthrotomies, volumes that were needed in order to effectively diagnose, mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations, significantly less fluid

38515_task2

Sentence: Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee . Instructions: please extract entity words from the input sentence

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Detection of traumatic arthrotomy of the knee using the saline solution load test . BACKGROUND The saline solution load test helps to determine if a wound extends into the knee joint . Little is known about the volume of injected intra-articular saline solution that is needed to effectively rule in or rule out a traumatic arthrotomy of the knee . The purpose of the present study was to determine the appropriate volume and needle location for the diagnosis of a traumatic knee arthrotomy and to assess the effect of associated variables , including knee circumference , body mass index , and sex . METHODS Fifty-six consecutive patients scheduled for knee arthroscopy were enrolled . A standard inferolateral arthroscopic portal was made with a single stab incision with use of a number-11 blade . Injection sites were randomized to either a superomedial or inferomedial location . The injection of normal saline solution at a rate of 5 mL/sec through an 18-gauge needle was continued while the knee was moved through a range of motion until fluid extravasated from the iatrogenic laceration . The volume of injected fluid was recorded . RESULTS The study group included thirty-one female patients and twenty-five male patients with a combined average age of fifty years and an average body mass index of 30.9 . In order to effectively diagnose 50 % of the arthrotomies , 75 mL of injected fluid was needed ; the volumes that were needed in order to effectively diagnose 75 % , 90 % , 95 % , and 99 % of the arthrotomies were 110 , 145 , 155 , and 175 mL , respectively . The mean volumes of injected fluid needed for a positive result at the inferomedial and superomedial needle locations were 64.0 and 95.2 mL , respectively ; this difference was significant ( p = 0.01 ) . There was no correlation between necessary injection volume and sex , body mass index , or knee circumference . CONCLUSIONS In order to detect 95 % of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test , 155 mL must be injected . An inferomedial injection location requires significantly less fluid than a superomedial injection location does for the diagnosis of inferolateral arthrotomies of the knee .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Physical", "Participant_Condition", "Participant_Age", "Intervention_Educational", "Participant_Sample-size", "Participant_Sex" ]

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DerChirurg.00710877.ger.abstr_task0

Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .

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DerChirurg.00710877.ger.abstr_task1

Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please typing these entity words according to sentence: Neubildungen, Pleura, Perikards, Deutschland, Asbestgefaehrdung, Berufskrankheiten, Aetiologie, Standard, Diagnostik, Chirurgie, chromosomale, Tumorentstehung, Diagnose, gezielter, Biopsieentnahme, Chirurgie, Diagnostik, Tumoren, Haeute Options: umlsterm

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Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .

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[ "umlsterm" ]

Neubildungen, Pleura, Perikards, Deutschland, Asbestgefaehrdung, Berufskrankheiten, Aetiologie, Standard, Diagnostik, Chirurgie, chromosomale, Tumorentstehung, Diagnose, gezielter, Biopsieentnahme, Chirurgie, Diagnostik, Tumoren, Haeute

DerChirurg.00710877.ger.abstr_task2

Sentence: Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Die Incidenz primaerer maligner Neubildungen der Pleura , des Perikards und des Peritoneums steigt seit Mitte der 80 er Jahre aufgrund der in Deutschland zwischen 1965 und 1980 teilweise erheblichen Asbestgefaehrdung in zahlreichen Industriezweigen kontinuierlich an . Mit einem weiteren Anstieg bis etwa 2020 ist zu rechnen . Etwa 90 % aller im Deutschen Mesotheliomregister erfassten Mesotheliome sind asbestassoziiert und somit als potenzielle Berufskrankheiten einzuordnen . Derzeit werden im Deutschen Mesotheliomregister in Bochum jaehrlich mehr als 500 Mesotheliome erfasst . Im ersten Teil der Serie ueber Mesotheliome werden aktuelle Konzepte zu Aetiologie und Pathogenese sowie der derzeitige Standard der Diagnostik vor dem Hintergrund der zunehmenden Aktualitaet fuer das Fachgebiet der Chirurgie referiert . Spezifische chromosomale oder genetische Defekte , die konstant zur Entwicklung maligner Mesotheliome fuehren , sind derzeit nicht bekannt . Vielmehr handelt es sich bei der Tumorentstehung um einen komplexen Vorgang , dem individuell unterschiedliche genetische Veraenderungen zugrundeliegen . Basis fuer therapeutische , prognostische und versicherungsmedizinische Konsequenzen ist eine verlaessliche Diagnose , die in der Regel zuverlaessig durch thoracoskopische Inspektionen mit gezielter Biopsieentnahme erzielt werden kann . Die Chirurgie kann unter der Voraussetzung einer verbesserten Diagnostik mit Erfassung frueher Entwicklungsphasen maligner Tumoren der seroesen Haeute zunehmende Bedeutung im Hinblick auf operative therapeutische Verfahren nicht nur zur Palliation , sondern auch unter kurativen Gesichtspunkten gewinnen .

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[ "umlsterm" ]

Interleukin-3 expression is an other_name, activated T cells is a cell_type, T - cell - specific factor is a protein_family_or_group, octamer binding protein is a protein_domain_or_region

84492_task0

Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, protein_domain_or_region, other_name

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.

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[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]

Interleukin-3 expression is an other_name, activated T cells is a cell_type, T - cell - specific factor is a protein_family_or_group, octamer binding protein is a protein_domain_or_region

84492_task1

Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please typing these entity words according to sentence: Interleukin-3 expression, activated T cells, T - cell - specific factor, octamer binding protein Options: cell_type, protein_family_or_group, protein_domain_or_region, other_name

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.

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[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]

Interleukin-3 expression, activated T cells, T - cell - specific factor, octamer binding protein

84492_task2

Sentence: Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Instructions: please extract entity words from the input sentence

[ "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.

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[ "protein_family_or_group", "other_name", "protein_domain_or_region", "DNA_domain_or_region", "cell_type", "protein_molecule" ]

Behandlung is an umlsterm, Radiusfrakturen is an umlsterm, Frakturreposition is an umlsterm, Zusatzverletzungen is an umlsterm, Bandverbindungen is an umlsterm, Zusatzverletzungen is an umlsterm, Therapie is an umlsterm, Radiusfrakturen is an umlsterm, Frakturen is an umlsterm, Bandlaesionen is an umlsterm, Patienten is an umlsterm

DerUnfallchirurg.71000430.ger.abstr_task0

Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .

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[ "umlsterm" ]

Behandlung is an umlsterm, Radiusfrakturen is an umlsterm, Frakturreposition is an umlsterm, Zusatzverletzungen is an umlsterm, Bandverbindungen is an umlsterm, Zusatzverletzungen is an umlsterm, Therapie is an umlsterm, Radiusfrakturen is an umlsterm, Frakturen is an umlsterm, Bandlaesionen is an umlsterm, Patienten is an umlsterm

DerUnfallchirurg.71000430.ger.abstr_task1

Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please typing these entity words according to sentence: Behandlung, Radiusfrakturen, Frakturreposition, Zusatzverletzungen, Bandverbindungen, Zusatzverletzungen, Therapie, Radiusfrakturen, Frakturen, Bandlaesionen, Patienten Options: umlsterm

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Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .

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[ "umlsterm" ]

Behandlung, Radiusfrakturen, Frakturreposition, Zusatzverletzungen, Bandverbindungen, Zusatzverletzungen, Therapie, Radiusfrakturen, Frakturen, Bandlaesionen, Patienten

DerUnfallchirurg.71000430.ger.abstr_task2

Sentence: Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert . Instructions: please extract entity words from the input sentence

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Das Endergebnis der Behandlung distaler intraartikulaerer Radiusfrakturen ist sowohl von der Frakturreposition als auch von eventuellen Zusatzverletzungen abhaengig . Vor allem Laesionen der karpalen Bandverbindungen fuehren unbehandelt zu ausgepraegten degenerativen Schaedigungen . Durch zunehmenden Einsatz der Handgelenkarthroskopie koennen diese Zusatzverletzungen fruehzeitig diagnostiziert und einer adaequaten Therapie zugefuehrt werden . Seit 1993 haben wir 23 distale intraartikulaere Radiusfrakturen ( vornehmlich C-Frakturen nach AO bzw. Frakturen der Gruppen VII und VIII nach Frykman ) arthroskopisch assistiert versorgt , wobei wir in 11 Faellen ( 47,8% skapholunaere Bandlaesionen ) feststellen konnten ; 7 dieser Patienten ( 64% ) waren arthroskopisch und bei der intraoperativen Pruefung instabil und wurden in der selben Sitzung minimal-invasiv stabilisiert .

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[ "umlsterm" ]

XIST is a Protein, XIST is a Protein, XIST is a Protein, histone H4 is a Protein, ZXDA is a Protein, ZXDB is a Protein, PHKA1 is a Protein, XIST is a Protein, XIST is a Protein

8079992_task0

Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

XIST is a Protein, XIST is a Protein, XIST is a Protein, histone H4 is a Protein, ZXDA is a Protein, ZXDB is a Protein, PHKA1 is a Protein, XIST is a Protein, XIST is a Protein

8079992_task1

Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: XIST, XIST, XIST, histone H4, ZXDA, ZXDB, PHKA1, XIST, XIST Options: Protein

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The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

XIST, XIST, XIST, histone H4, ZXDA, ZXDB, PHKA1, XIST, XIST

8079992_task2

Sentence: The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence

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The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype. Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed. As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active. We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes. The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active. We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes. Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA. Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

bone marrow of patients with acute myeloid leukemia . is a Participant_Condition, immunohistochemical analysis of bone marrow biopsies is a Intervention_Physical, Expression of VEGF and VEGFR-2 is a Outcome_Physical, remission is a Outcome_Physical, induction chemotherapy is a Intervention_Pharmacological, VEGFR-2 staining levels is a Outcome_Physical, VEGF / VEGFR-2 of leukemic blasts is a Outcome_Physical, antiangiogenic is a Intervention_Other

9728_task0

Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Intervention_Other, Outcome_Physical

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Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]

bone marrow of patients with acute myeloid leukemia . is a Participant_Condition, immunohistochemical analysis of bone marrow biopsies is a Intervention_Physical, Expression of VEGF and VEGFR-2 is a Outcome_Physical, remission is a Outcome_Physical, induction chemotherapy is a Intervention_Pharmacological, VEGFR-2 staining levels is a Outcome_Physical, VEGF / VEGFR-2 of leukemic blasts is a Outcome_Physical, antiangiogenic is a Intervention_Other

9728_task1

Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please typing these entity words according to sentence: bone marrow of patients with acute myeloid leukemia ., immunohistochemical analysis of bone marrow biopsies, Expression of VEGF and VEGFR-2, remission, induction chemotherapy, VEGFR-2 staining levels, VEGF / VEGFR-2 of leukemic blasts, antiangiogenic Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Intervention_Other, Outcome_Physical

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Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]

bone marrow of patients with acute myeloid leukemia ., immunohistochemical analysis of bone marrow biopsies, Expression of VEGF and VEGFR-2, remission, induction chemotherapy, VEGFR-2 staining levels, VEGF / VEGFR-2 of leukemic blasts, antiangiogenic

9728_task2

Sentence: Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML . Instructions: please extract entity words from the input sentence

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Overexpression of vascular endothelial growth factor ( VEGF ) and its cellular receptor KDR ( VEGFR-2 ) in the bone marrow of patients with acute myeloid leukemia . Vascular endothelial growth factor ( VEGF ) and its cellular receptor VEGFR-2 have been implicated as the main endothelial pathway required for tumor neovascularization . However , the importance of the VEGF/VEGFR-2 system for angiogenesis in hematologic malignancies such as AML remains to be elucidated . In 32 patients with newly diagnosed untreated AML , we observed by immunohistochemical analysis of bone marrow biopsies significantly higher levels of VEGF and VEGFR-2 expression than in 10 control patients ( P < 0.001 ) . In contrast , VEGFR-1 staining levels in AML patients were in the same range as in the controls . Expression of VEGF and VEGFR-2 was significantly higher in patients with a high degree of microvessel density compared to those with a low degree ( VEGF : P =0.024 ; VEGFR-2 : P =0.040 ) and correlated well with bone marrow microvessel density ( r ( s ) =0.566 and 0.609 , respectively ; P < 0.001 ) . Furthermore , in patients who achieved a complete remission following induction chemotherapy VEGFR-2 staining levels decreased into the normal range . In conclusion , our results provide evidence for increased expression of VEGF/VEGFR-2 of leukemic blasts and correlation with angiogenesis in the bone marrow of AML patients . Thus , VEGF/VEGFR-2 might constitute promising targets for antiangiogenic and antileukemic treatment strategies in AML .

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[ "Participant_Condition", "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Other" ]

Patienten is an umlsterm, rueckenmarknaher is an umlsterm, Regionalanaesthesie is an umlsterm, Sauerstoffpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Haemodynamik is an umlsterm, Blutdruck is an umlsterm

DerAnaesthesist.90480379.ger.abstr_task0

Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .

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[ "umlsterm" ]

Patienten is an umlsterm, rueckenmarknaher is an umlsterm, Regionalanaesthesie is an umlsterm, Sauerstoffpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Haemodynamik is an umlsterm, Blutdruck is an umlsterm

DerAnaesthesist.90480379.ger.abstr_task1

Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please typing these entity words according to sentence: Patienten, rueckenmarknaher, Regionalanaesthesie, Sauerstoffpartialdruck, Sauerstoffsaettigung, Haemodynamik, Blutdruck Options: umlsterm

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Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .

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[ "umlsterm" ]

Patienten, rueckenmarknaher, Regionalanaesthesie, Sauerstoffpartialdruck, Sauerstoffsaettigung, Haemodynamik, Blutdruck

DerAnaesthesist.90480379.ger.abstr_task2

Sentence: Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Fragestellung : Ziel unserer Untersuchung war es , moegliche kognitive Funktionsdefizite geriatrischer Patienten nach Allgemein- und rueckenmarknaher Regionalanaesthesie mit Parametern des Gasaustauschs ( Sauerstoffpartialdruck paO2, Sauerstoffsaettigung SatO2) und der Haemodynamik ( arterieller systolischer und mittlerer Blutdruck RRs und MAP ) in Beziehung zu setzen .

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[ "umlsterm" ]

devices is an umlsterm, heart is an umlsterm, devices is an umlsterm, patients is an umlsterm, heart transplantation is an umlsterm, devices is an umlsterm, patient selection is an umlsterm, patient care is an umlsterm, device is an umlsterm, maintenance is an umlsterm, patients is an umlsterm, devices is an umlsterm, secondary is an umlsterm, heart is an umlsterm, function is an umlsterm, patients is an umlsterm, costs is an umlsterm, patients is an umlsterm

ZfuerKardiologie.0089vii91.eng.abstr_task0

Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .

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[ "umlsterm" ]

devices is an umlsterm, heart is an umlsterm, devices is an umlsterm, patients is an umlsterm, heart transplantation is an umlsterm, devices is an umlsterm, patient selection is an umlsterm, patient care is an umlsterm, device is an umlsterm, maintenance is an umlsterm, patients is an umlsterm, devices is an umlsterm, secondary is an umlsterm, heart is an umlsterm, function is an umlsterm, patients is an umlsterm, costs is an umlsterm, patients is an umlsterm

ZfuerKardiologie.0089vii91.eng.abstr_task1

Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please typing these entity words according to sentence: devices, heart, devices, patients, heart transplantation, devices, patient selection, patient care, device, maintenance, patients, devices, secondary, heart, function, patients, costs, patients Options: umlsterm

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Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .

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[ "umlsterm" ]

devices, heart, devices, patients, heart transplantation, devices, patient selection, patient care, device, maintenance, patients, devices, secondary, heart, function, patients, costs, patients

ZfuerKardiologie.0089vii91.eng.abstr_task2

Sentence: Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients . Instructions: please extract entity words from the input sentence

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Mechanical circulatory support devices were first developed to permanently replace the failing heart . Today , however , the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation . With this indication , important information on using mechanical assist devices has been assembled . We present our experience , which has been gained since 1987 in the area of patient selection , post-implant patient care and device maintenance . More than 450 patients have since been implanted with assist devices at our institution . Mechanical circulatory support may not only lead to recovery from secondary organ failure , but also to myocardial reremodeling and recovery of the heart function in some patients . Additionally we report our experience with a newly developed implantable axial flow pump and discuss the possibility and costs of permanent support in some patients .

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[ "umlsterm" ]

carbon is a CHEMICAL

12668769_task0

Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]

Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.

[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

carbon is a CHEMICAL

12668769_task1

Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please typing these entity words according to sentence: carbon Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]

Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.

[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

carbon

12668769_task2

Sentence: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]

Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.

[ "Investigating", "the", "regulation", "of", "one", "-", "carbon", "metabolism", "in", "Arabidopsis", "thaliana", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

EUROSCAN is a Intervention_Physical

31917_task0

Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical

[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]

The EUROSCAN Study . EUROSCAN Steering Committee .

[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]

[ "Intervention_Physical", "Participant_Condition" ]

EUROSCAN is a Intervention_Physical

31917_task1

Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please typing these entity words according to sentence: EUROSCAN Options: Intervention_Physical

[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]

The EUROSCAN Study . EUROSCAN Steering Committee .

[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]

[ "Intervention_Physical", "Participant_Condition" ]

EUROSCAN

31917_task2

Sentence: The EUROSCAN Study . EUROSCAN Steering Committee . Instructions: please extract entity words from the input sentence

[ "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O" ]

The EUROSCAN Study . EUROSCAN Steering Committee .

[ "The", "EUROSCAN", "Study", ".", "EUROSCAN", "Steering", "Committee", "." ]

[ "Intervention_Physical", "Participant_Condition" ]

Estrogen receptor concentration is an other_name, social factors is an other_name, natural killer cell activity is an other_name, early - stage breast cancer patients is a multi_cell

100587_task0

Sentence: Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: multi_cell, other_name

[ "B-other_name", "I-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "O", "O", "O", "O", "O", "O" ]

Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model.

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[ "other_name", "(AND multi_cell multi_cell)", "multi_cell", "", "protein_family_or_group", "cell_type", "tissue" ]

Estrogen receptor concentration is an other_name, social factors is an other_name, natural killer cell activity is an other_name, early - stage breast cancer patients is a multi_cell

100587_task1

Sentence: Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model. Instructions: please typing these entity words according to sentence: Estrogen receptor concentration, social factors, natural killer cell activity, early - stage breast cancer patients Options: multi_cell, other_name

[ "B-other_name", "I-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "I-multi_cell", "O", "O", "O", "O", "O", "O" ]

Estrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients. Confirmation of a model.

[ "Estrogen", "receptor", "concentration", "and", "social", "factors", "as", "predictors", "of", "natural", "killer", "cell", "activity", "in", "early", "-", "stage", "breast", "cancer", "patients", ".", "Confirmation", "of", "a", "model", "." ]

[ "other_name", "(AND multi_cell multi_cell)", "multi_cell", "", "protein_family_or_group", "cell_type", "tissue" ]