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children is an umlsterm, adolescents is an umlsterm, tics is an umlsterm, obsessive - compulsive behavior is an umlsterm, symptoms is an umlsterm, single is an umlsterm, tics is an umlsterm, obsessions is an umlsterm, compulsions is an umlsterm, dysfunctions is an umlsterm, tic is an umlsterm, obsessive - compulsive behavior is an umlsterm, behavioral therapy is an umlsterm, control is an umlsterm, tics is an umlsterm, obsessive - compulsive behavior is an umlsterm, neurotransmitter is an umlsterm, symptom - continuum is an umlsterm, therapeutic is an umlsterm, development is an umlsterm, patient is an umlsterm
DerNervenarzt.90700001.eng.abstr_task0
Sentence: In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]
In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient .
[ "In", "children", "and", "adolescents", "motor", "/", "vocal", "tics", "and", "obsessive", "-", "compulsive", "behavior", "are", "known", "to", "be", "closely", "related", ".", "Thereby", ",", "a", "continuum", "of", "symptoms", "ranging", "from", "single", "tics", "to", "a", "mixed", "picture", "of", "tics", "/", "rituals", "/", "obsessive", "-", "compulsive", "traits", "to", "clinically", "relevant", "obsessions", "and", "compulsions", "could", "be", "described", ".", "As", "neurobiological", "substrates", "dysfunctions", "in", "corresponding", "cortico", "-", "striato", "-", "thalamo", "-", "cortical", "circuits", "(", "sensorimotor", "circuit", "in", "tic", "symptomatology", ",", "orbitofrontal", "circuit", "in", "obsessive", "-", "compulsive", "behavior", ")", "were", "postulated", ".", "For", "both", "disturbances", "behavioral", "therapy", "can", "be", "used", "to", "improve", "control", "mechanisms", "to", "counterregulate", "tics", "and", "obsessive", "-", "compulsive", "behavior", ",", "respectively", ",", "and", "psychopharmacological", "agents", "can", "be", "administerd", "to", "compensate", "dysbalances", "in", "neurotransmitter", "systems", ".", "In", "case", "of", "a", "mixed", "symptomatologic", "picture", "it", "is", "necessary", "to", "include", "interventions", "for", "both", "pols", "of", "the", "symptom", "-", "continuum", "in", "the", "therapeutic", "programme", "to", "achieve", "extensive", "improvement", "as", "a", "basis", "for", "a", "further", "positive", "development", "of", "the", "patient", "." ]
[ "umlsterm" ]
children is an umlsterm, adolescents is an umlsterm, tics is an umlsterm, obsessive - compulsive behavior is an umlsterm, symptoms is an umlsterm, single is an umlsterm, tics is an umlsterm, obsessions is an umlsterm, compulsions is an umlsterm, dysfunctions is an umlsterm, tic is an umlsterm, obsessive - compulsive behavior is an umlsterm, behavioral therapy is an umlsterm, control is an umlsterm, tics is an umlsterm, obsessive - compulsive behavior is an umlsterm, neurotransmitter is an umlsterm, symptom - continuum is an umlsterm, therapeutic is an umlsterm, development is an umlsterm, patient is an umlsterm
DerNervenarzt.90700001.eng.abstr_task1
Sentence: In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient . Instructions: please typing these entity words according to sentence: children, adolescents, tics, obsessive - compulsive behavior, symptoms, single, tics, obsessions, compulsions, dysfunctions, tic, obsessive - compulsive behavior, behavioral therapy, control, tics, obsessive - compulsive behavior, neurotransmitter, symptom - continuum, therapeutic, development, patient Options: umlsterm
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In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient .
[ "In", "children", "and", "adolescents", "motor", "/", "vocal", "tics", "and", "obsessive", "-", "compulsive", "behavior", "are", "known", "to", "be", "closely", "related", ".", "Thereby", ",", "a", "continuum", "of", "symptoms", "ranging", "from", "single", "tics", "to", "a", "mixed", "picture", "of", "tics", "/", "rituals", "/", "obsessive", "-", "compulsive", "traits", "to", "clinically", "relevant", "obsessions", "and", "compulsions", "could", "be", "described", ".", "As", "neurobiological", "substrates", "dysfunctions", "in", "corresponding", "cortico", "-", "striato", "-", "thalamo", "-", "cortical", "circuits", "(", "sensorimotor", "circuit", "in", "tic", "symptomatology", ",", "orbitofrontal", "circuit", "in", "obsessive", "-", "compulsive", "behavior", ")", "were", "postulated", ".", "For", "both", "disturbances", "behavioral", "therapy", "can", "be", "used", "to", "improve", "control", "mechanisms", "to", "counterregulate", "tics", "and", "obsessive", "-", "compulsive", "behavior", ",", "respectively", ",", "and", "psychopharmacological", "agents", "can", "be", "administerd", "to", "compensate", "dysbalances", "in", "neurotransmitter", "systems", ".", "In", "case", "of", "a", "mixed", "symptomatologic", "picture", "it", "is", "necessary", "to", "include", "interventions", "for", "both", "pols", "of", "the", "symptom", "-", "continuum", "in", "the", "therapeutic", "programme", "to", "achieve", "extensive", "improvement", "as", "a", "basis", "for", "a", "further", "positive", "development", "of", "the", "patient", "." ]
[ "umlsterm" ]
children, adolescents, tics, obsessive - compulsive behavior, symptoms, single, tics, obsessions, compulsions, dysfunctions, tic, obsessive - compulsive behavior, behavioral therapy, control, tics, obsessive - compulsive behavior, neurotransmitter, symptom - continuum, therapeutic, development, patient
DerNervenarzt.90700001.eng.abstr_task2
Sentence: In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]
In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient .
[ "In", "children", "and", "adolescents", "motor", "/", "vocal", "tics", "and", "obsessive", "-", "compulsive", "behavior", "are", "known", "to", "be", "closely", "related", ".", "Thereby", ",", "a", "continuum", "of", "symptoms", "ranging", "from", "single", "tics", "to", "a", "mixed", "picture", "of", "tics", "/", "rituals", "/", "obsessive", "-", "compulsive", "traits", "to", "clinically", "relevant", "obsessions", "and", "compulsions", "could", "be", "described", ".", "As", "neurobiological", "substrates", "dysfunctions", "in", "corresponding", "cortico", "-", "striato", "-", "thalamo", "-", "cortical", "circuits", "(", "sensorimotor", "circuit", "in", "tic", "symptomatology", ",", "orbitofrontal", "circuit", "in", "obsessive", "-", "compulsive", "behavior", ")", "were", "postulated", ".", "For", "both", "disturbances", "behavioral", "therapy", "can", "be", "used", "to", "improve", "control", "mechanisms", "to", "counterregulate", "tics", "and", "obsessive", "-", "compulsive", "behavior", ",", "respectively", ",", "and", "psychopharmacological", "agents", "can", "be", "administerd", "to", "compensate", "dysbalances", "in", "neurotransmitter", "systems", ".", "In", "case", "of", "a", "mixed", "symptomatologic", "picture", "it", "is", "necessary", "to", "include", "interventions", "for", "both", "pols", "of", "the", "symptom", "-", "continuum", "in", "the", "therapeutic", "programme", "to", "achieve", "extensive", "improvement", "as", "a", "basis", "for", "a", "further", "positive", "development", "of", "the", "patient", "." ]
[ "umlsterm" ]
tumor necrosis factor is a Protein, interleukin-7 is a Protein, Tumor necrosis factor is a Protein, TNF is a Protein, interleukin-7 is a Protein, IL-7 is a Protein, TNF is a Protein, IL-7 is a Protein, p75 TNF receptor is a Protein, TNF is a Protein, TNF is a Protein, TNF is a Protein, CD4 is a Protein, TNF is a Protein, IL-7 is a Protein, TNF is a Protein
10438843_task0
Sentence: Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells.
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[ "Protein" ]
tumor necrosis factor is a Protein, interleukin-7 is a Protein, Tumor necrosis factor is a Protein, TNF is a Protein, interleukin-7 is a Protein, IL-7 is a Protein, TNF is a Protein, IL-7 is a Protein, p75 TNF receptor is a Protein, TNF is a Protein, TNF is a Protein, TNF is a Protein, CD4 is a Protein, TNF is a Protein, IL-7 is a Protein, TNF is a Protein
10438843_task1
Sentence: Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells. Instructions: please typing these entity words according to sentence: tumor necrosis factor, interleukin-7, Tumor necrosis factor, TNF, interleukin-7, IL-7, TNF, IL-7, p75 TNF receptor, TNF, TNF, TNF, CD4, TNF, IL-7, TNF Options: Protein
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Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells.
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[ "Protein" ]
tumor necrosis factor, interleukin-7, Tumor necrosis factor, TNF, interleukin-7, IL-7, TNF, IL-7, p75 TNF receptor, TNF, TNF, TNF, CD4, TNF, IL-7, TNF
10438843_task2
Sentence: Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells. Instructions: please extract entity words from the input sentence
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Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7. This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment. In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes. Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation. TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor. The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes. Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC. The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7. Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes. However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells.
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[ "Protein" ]
MIP1 alpha nuclear protein is a protein_molecule, MNP is a protein_molecule, transcription factor is a protein_family_or_group, human MIP-1 alpha gene is a DNA_domain_or_region
1422_task0
Sentence: MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, protein_family_or_group, protein_molecule
[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.
[ "MIP1", "alpha", "nuclear", "protein", "(", "MNP", ")", ",", "a", "novel", "transcription", "factor", "expressed", "in", "hematopoietic", "cells", "that", "is", "crucial", "for", "transcription", "of", "the", "human", "MIP-1", "alpha", "gene", "." ]
[ "protein_molecule", "DNA_domain_or_region", "protein_complex", "cell_type", "protein_domain_or_region", "other_name", "protein_family_or_group", "cell_line", "cell_component", "tissue" ]
MIP1 alpha nuclear protein is a protein_molecule, MNP is a protein_molecule, transcription factor is a protein_family_or_group, human MIP-1 alpha gene is a DNA_domain_or_region
1422_task1
Sentence: MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene. Instructions: please typing these entity words according to sentence: MIP1 alpha nuclear protein, MNP, transcription factor, human MIP-1 alpha gene Options: DNA_domain_or_region, protein_family_or_group, protein_molecule
[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.
[ "MIP1", "alpha", "nuclear", "protein", "(", "MNP", ")", ",", "a", "novel", "transcription", "factor", "expressed", "in", "hematopoietic", "cells", "that", "is", "crucial", "for", "transcription", "of", "the", "human", "MIP-1", "alpha", "gene", "." ]
[ "protein_molecule", "DNA_domain_or_region", "protein_complex", "cell_type", "protein_domain_or_region", "other_name", "protein_family_or_group", "cell_line", "cell_component", "tissue" ]
MIP1 alpha nuclear protein, MNP, transcription factor, human MIP-1 alpha gene
1422_task2
Sentence: MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene. Instructions: please extract entity words from the input sentence
[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.
[ "MIP1", "alpha", "nuclear", "protein", "(", "MNP", ")", ",", "a", "novel", "transcription", "factor", "expressed", "in", "hematopoietic", "cells", "that", "is", "crucial", "for", "transcription", "of", "the", "human", "MIP-1", "alpha", "gene", "." ]
[ "protein_molecule", "DNA_domain_or_region", "protein_complex", "cell_type", "protein_domain_or_region", "other_name", "protein_family_or_group", "cell_line", "cell_component", "tissue" ]
IL-1 receptor is a Protein, interleukin-1 receptor type I is a Protein, IL-1RI is a Protein, complex system is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity, IL-1RI is a Protein, N - Acetylcysteine is a Entity, glutathione is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity, IL-1RI is a Protein, complex is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity
745_task0
Sentence: Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
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Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.
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[ "Protein", "Entity" ]
IL-1 receptor is a Protein, interleukin-1 receptor type I is a Protein, IL-1RI is a Protein, complex system is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity, IL-1RI is a Protein, N - Acetylcysteine is a Entity, glutathione is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity, IL-1RI is a Protein, complex is a Entity, IL-1RI is a Protein, NF - kappa B is a Entity
745_task1
Sentence: Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation. Instructions: please typing these entity words according to sentence: IL-1 receptor, interleukin-1 receptor type I, IL-1RI, complex system, IL-1RI, NF - kappa B, IL-1RI, N - Acetylcysteine, glutathione, IL-1RI, NF - kappa B, IL-1RI, complex, IL-1RI, NF - kappa B Options: Entity, Protein
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Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.
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[ "Protein", "Entity" ]
IL-1 receptor, interleukin-1 receptor type I, IL-1RI, complex system, IL-1RI, NF - kappa B, IL-1RI, N - Acetylcysteine, glutathione, IL-1RI, NF - kappa B, IL-1RI, complex, IL-1RI, NF - kappa B
745_task2
Sentence: Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation. Instructions: please extract entity words from the input sentence
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Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B. The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals. The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur.J.Immunol.1994.24: 1566). IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation. We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation. A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status. Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase. N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect. The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine. The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells. From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.
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[ "Protein", "Entity" ]
cystic is a Pathological_formation, glandular tissue is a Tissue, conjunctive tissue is a Tissue, ovarian is a Organ
PMID-899346_task0
Sentence: [Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Organ, Tissue
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases.
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[ "Tissue", "Organ", "Pathological_formation" ]
cystic is a Pathological_formation, glandular tissue is a Tissue, conjunctive tissue is a Tissue, ovarian is a Organ
PMID-899346_task1
Sentence: [Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases. Instructions: please typing these entity words according to sentence: cystic, glandular tissue, conjunctive tissue, ovarian Options: Pathological_formation, Organ, Tissue
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[Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases.
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[ "Tissue", "Organ", "Pathological_formation" ]
cystic, glandular tissue, conjunctive tissue, ovarian
PMID-899346_task2
Sentence: [Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases. Instructions: please extract entity words from the input sentence
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[Considerations regarding two cases of macromastia (author's transl)]. Two cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both cases a cystic degeneracy of the glandular tissue with a hyperplazia and hypertrophy of the conjunctive tissue. The pathogeny of macromastia is being discussed and it is demonstrated both the role of hypophysis hormones (prolactine and growth hormone) and of ovarian hormones (estrogens). The treatment was surgical for the both cases.
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[ "Tissue", "Organ", "Pathological_formation" ]
Therapie is an umlsterm, Prostatakarzinoms is an umlsterm, Analyse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm, Prognose is an umlsterm, Karzinoms is an umlsterm, multivariaten Analysen is an umlsterm, Therapieplanung is an umlsterm, Tumoranteiles is an umlsterm, Biopsietechnik is an umlsterm, Analyse is an umlsterm, Tumoranteile is an umlsterm, Gewebeproben is an umlsterm, Prognosefaktoren is an umlsterm, Forschung is an umlsterm, Analyse is an umlsterm, Tumoranteiles is an umlsterm, Patientenserien is an umlsterm
DerUrologeA.00390014.ger.abstr_task0
Sentence: Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt .
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[ "umlsterm" ]
Therapie is an umlsterm, Prostatakarzinoms is an umlsterm, Analyse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm, Prognose is an umlsterm, Karzinoms is an umlsterm, multivariaten Analysen is an umlsterm, Therapieplanung is an umlsterm, Tumoranteiles is an umlsterm, Biopsietechnik is an umlsterm, Analyse is an umlsterm, Tumoranteile is an umlsterm, Gewebeproben is an umlsterm, Prognosefaktoren is an umlsterm, Forschung is an umlsterm, Analyse is an umlsterm, Tumoranteiles is an umlsterm, Patientenserien is an umlsterm
DerUrologeA.00390014.ger.abstr_task1
Sentence: Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt . Instructions: please typing these entity words according to sentence: Therapie, Prostatakarzinoms, Analyse, Patienten, Tumors, Prognose, Karzinoms, multivariaten Analysen, Therapieplanung, Tumoranteiles, Biopsietechnik, Analyse, Tumoranteile, Gewebeproben, Prognosefaktoren, Forschung, Analyse, Tumoranteiles, Patientenserien Options: umlsterm
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Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt .
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[ "umlsterm" ]
Therapie, Prostatakarzinoms, Analyse, Patienten, Tumors, Prognose, Karzinoms, multivariaten Analysen, Therapieplanung, Tumoranteiles, Biopsietechnik, Analyse, Tumoranteile, Gewebeproben, Prognosefaktoren, Forschung, Analyse, Tumoranteiles, Patientenserien
DerUrologeA.00390014.ger.abstr_task2
Sentence: Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt . Instructions: please extract entity words from the input sentence
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Die Indikationsstellung zur Therapie des Prostatakarzinoms bei einer moeglichst genauen Analyse prognostischer Faktoren , um Erfolgsaussichten und Benefit fuer den Patienten abschaetzen zu koennen . Der Anteil des niedrigdifferenzierten Tumors bestimmt die Prognose des Karzinoms , viele der ueblich angewandten prognostischen Kriterien konnten in multivariaten Analysen als kolineare Faktoren ohne unabhaengige prognostische Relevanz charakterisiert werden . Entscheidend fuer die Therapieplanung ist eine moeglichst exakte praetherapeutische Abschaetzung des niedrigdifferenzierten Tumoranteiles . Dies gelingt weitgehend durch eine standartisierte Biopsietechnik sowie eine quantifizierte Analyse der gefundenen Tumoranteile in den Gewebeproben . Die prognostische Wertigkeit molekularbiologischer und anderer Prognosefaktoren ist Gegenstand intensiver Forschung , eine Ueberlegenheit gegenueber der quantifizierten Analyse des niedrigdifferenzierten Tumoranteiles konnte bislang nur in kleinen Patientenserien gezeigt werden . In der taeglichen Routine erscheint ihr Einsatz aufgrund des hohen technischen und finanziellen Aufwandes zum jetzigen Zeitpunkt nicht gerechtfertigt .
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[ "umlsterm" ]
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DerUnfallchirurg.81010491.eng.abstr_task0
Sentence: In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome .
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[ "umlsterm" ]
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DerUnfallchirurg.81010491.eng.abstr_task1
Sentence: In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome . Instructions: please typing these entity words according to sentence: postoperative, compartment syndrome, anterior, palsy, peroneal nerve, anterior cruciate ligament, knee, tourniquet, pressure, operation, time, operation, leg, leg, prophylaxis, Analgesic, therapy, bupivacaine, pain, leg, analgesia, pain, analgesia, patient, hospital, postoperative, anterior, pressure, muscle, perfusion, muscles, islands, ischemic, necrosis, palsy, foot, compartment syndrome, tourniquet, limb, arthroscopy, bandage, epidural analgesia, masks, symptoms, compartment syndrome Options: umlsterm
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In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome .
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[ "umlsterm" ]
postoperative, compartment syndrome, anterior, palsy, peroneal nerve, anterior cruciate ligament, knee, tourniquet, pressure, operation, time, operation, leg, leg, prophylaxis, Analgesic, therapy, bupivacaine, pain, leg, analgesia, pain, analgesia, patient, hospital, postoperative, anterior, pressure, muscle, perfusion, muscles, islands, ischemic, necrosis, palsy, foot, compartment syndrome, tourniquet, limb, arthroscopy, bandage, epidural analgesia, masks, symptoms, compartment syndrome
DerUnfallchirurg.81010491.eng.abstr_task2
Sentence: In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome . Instructions: please extract entity words from the input sentence
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In this article we report a case of an early postoperative compartment syndrome of the anterior tibial compartment with complete sensomotoric palsy of the peroneal nerve after arthroscopic-assisted replacement of the anterior cruciate ligament ( ACL ) of the knee . The tourniquet pressure was 360 mm Hg and operation time was 1.75 h . After the operation the leg was bandaged to avoid swelling of the leg and as antithrombotic prophylaxis . Analgesic therapy was by continuous epidural bupivacaine infusion . Increasing pain of the lower leg was suppressed by additional analgesia . Due to persistent pain despite regular analgesia , the patient was sent to a main hospital on the 3rd postoperative day , where an extremely painful and swollen anterior tibial compartment with intracompartimental pressure of over 100 mm Hg was found . The compartment was released immediately . Despite the appearance of severe muscle damage , no extensive débridement was done . At the second examination , at 48 h , there was minimal perfusion of the muscles without contraction and islands of ischemic necrosis . Clinically , there was complete palsy of the dorsiflexors of the foot . The case shows the danger of a compartment syndrome when tourniquet of the limb , arthroscopy and a firm bandage are combined . Continuous epidural analgesia masks the classic symptoms of compartment syndrome .
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[ "umlsterm" ]
pregnancy is a Condition, legal custody is a Person, without is a Negation, health insurance is a Person, moribund is a Condition, procalcitonin concentration is a Measurement, increased is a Qualifier, poly - traumatised is a Condition, surgical interventions is a Procedure, last 4 days is a Temporal, cardiorespiratory arrest is a Condition, anti - thymocyte globulin is a Drug, immunodepressed is a Condition, bone marrow transplant patients , patients with severe neutropenia is a Scope, indication is a Condition, antibiotics is a Drug, ICU is a Visit, meningitis , pneumonia is a Scope, chronic infection is a Condition, long - term is a Qualifier, antibiotic treatment is a Procedure, ( endocarditis , osteo - articular infections , mediastinitis , deep abscesses , pneumocystis infection , toxoplasmosis , tuberculosis is a Scope, haemodynamic instability is a Condition, septic is a Condition, Pa02 / Fi02 = 200 mmHg and PEP = 5 cmH2O is a Scope
NCT02862314_exc_task0
Sentence: pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Person, Procedure, Negation, Scope, Measurement, Visit, Drug
[ "B-Condition", "O", "O", "O", "O", "B-Person", "I-Person", "O", "O", "O", "B-Negation", "B-Person", "I-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Drug", "O", "O", "O", "O", "B-Visit", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]
pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O)
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[ "Scope", "Measurement", "Condition", "Drug", "Procedure", "Person", "Temporal", "Value", "Qualifier", "Negation", "Visit" ]
pregnancy is a Condition, legal custody is a Person, without is a Negation, health insurance is a Person, moribund is a Condition, procalcitonin concentration is a Measurement, increased is a Qualifier, poly - traumatised is a Condition, surgical interventions is a Procedure, last 4 days is a Temporal, cardiorespiratory arrest is a Condition, anti - thymocyte globulin is a Drug, immunodepressed is a Condition, bone marrow transplant patients , patients with severe neutropenia is a Scope, indication is a Condition, antibiotics is a Drug, ICU is a Visit, meningitis , pneumonia is a Scope, chronic infection is a Condition, long - term is a Qualifier, antibiotic treatment is a Procedure, ( endocarditis , osteo - articular infections , mediastinitis , deep abscesses , pneumocystis infection , toxoplasmosis , tuberculosis is a Scope, haemodynamic instability is a Condition, septic is a Condition, Pa02 / Fi02 = 200 mmHg and PEP = 5 cmH2O is a Scope
NCT02862314_exc_task1
Sentence: pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O) Instructions: please typing these entity words according to sentence: pregnancy, legal custody, without, health insurance, moribund, procalcitonin concentration, increased, poly - traumatised, surgical interventions, last 4 days, cardiorespiratory arrest, anti - thymocyte globulin, immunodepressed, bone marrow transplant patients , patients with severe neutropenia, indication, antibiotics, ICU, meningitis , pneumonia, chronic infection, long - term, antibiotic treatment, ( endocarditis , osteo - articular infections , mediastinitis , deep abscesses , pneumocystis infection , toxoplasmosis , tuberculosis, haemodynamic instability, septic, Pa02 / Fi02 = 200 mmHg and PEP = 5 cmH2O Options: Temporal, Condition, Qualifier, Person, Procedure, Negation, Scope, Measurement, Visit, Drug
[ "B-Condition", "O", "O", "O", "O", "B-Person", "I-Person", "O", "O", "O", "B-Negation", "B-Person", "I-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Drug", "O", "O", "O", "O", "B-Visit", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]
pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O)
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[ "Scope", "Measurement", "Condition", "Drug", "Procedure", "Person", "Temporal", "Value", "Qualifier", "Negation", "Visit" ]
pregnancy, legal custody, without, health insurance, moribund, procalcitonin concentration, increased, poly - traumatised, surgical interventions, last 4 days, cardiorespiratory arrest, anti - thymocyte globulin, immunodepressed, bone marrow transplant patients , patients with severe neutropenia, indication, antibiotics, ICU, meningitis , pneumonia, chronic infection, long - term, antibiotic treatment, ( endocarditis , osteo - articular infections , mediastinitis , deep abscesses , pneumocystis infection , toxoplasmosis , tuberculosis, haemodynamic instability, septic, Pa02 / Fi02 = 200 mmHg and PEP = 5 cmH2O
NCT02862314_exc_task2
Sentence: pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O) Instructions: please extract entity words from the input sentence
[ "B-Condition", "O", "O", "O", "O", "B-Person", "I-Person", "O", "O", "O", "B-Negation", "B-Person", "I-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Drug", "O", "O", "O", "O", "B-Visit", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]
pregnancy, patients under legal custody, patients without health insurance, patients included in another interventional clinical study involving infections or antibiotics and having the same primary parameter, moribund patients, situation in which the procalcitonin concentration could be increased without correlation to an infectious process (poly-traumatised patients, surgical interventions within the last 4 days, cardiorespiratory arrest, administration of anti-thymocyte globulin, immunodepressed patients (bone marrow transplant patients, patients with severe neutropenia), patients with an absolute indication for administration of antibiotics at the moment of ICU admission (meningitis, pneumonia) or a chronic infection for which long-term antibiotic treatment is necessary (endocarditis, osteo-articular infections, mediastinitis, deep abscesses, pneumocystis infection, toxoplasmosis, tuberculosis) patients with haemodynamic instability of septic origin or a respiratory insufficiency (defined by a ratio Pa02/Fi02 = 200 mmHg and PEP = 5 cmH2O)
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[ "Scope", "Measurement", "Condition", "Drug", "Procedure", "Person", "Temporal", "Value", "Qualifier", "Negation", "Visit" ]
Research exemption requested is a Observation, History is a Observation, PCV-13 vaccination is a Procedure, History is a Observation, cochlear implant is a Device, Cerebrospinal Fluid ( CSF ) leak is a Condition, Congestive Heart Failure ( CHF ) is a Condition, Diabetes Mellitus ( DM ) is a Condition, Chronic Kidney Disease ( CKD ) is a Condition, Human Immunodeficiency Virus ( HIV ) is a Condition, Common Variable Immune Deficiency ( CVID ) is a Condition, PPSV23 vaccine is a Drug, in the last 5 years is a Temporal, Women is a Person, pregnant is a Condition, 2 is a Multiplier, point of care urine pregnancy tests is a Procedure, prior to vaccinations is a Temporal
NCT03260790_exc_task0
Sentence: Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Person, Observation, Multiplier, Procedure, Device, Drug
[ "B-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "O", "B-Procedure", "I-Procedure", "O", "B-Observation", "O", "B-Device", "I-Device", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Person", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multiplier", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O" ]
Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations)
[ "Research", "exemption", "requested", "\n", "History", "of", "PCV-13", "vaccination", "\n", "History", "of", "cochlear", "implant", "\n", "Cerebrospinal", "Fluid", "(", "CSF", ")", "leak", "\n", "Congestive", "Heart", "Failure", "(", "CHF", ")", "\n", "Diabetes", "Mellitus", "(", "DM", ")", "\n", "Chronic", "Kidney", "Disease", "(", "CKD", ")", "\n", "Human", "Immunodeficiency", "Virus", "(", "HIV", ")", "\n", "Common", "Variable", "Immune", "Deficiency", "(", "CVID", ")", "\n", "Patients", "who", "have", "received", "the", "PPSV23", "vaccine", "in", "the", "last", "5", "years", "\n", "Women", "who", "are", "pregnant", "will", "also", "be", "excluded", "from", "the", "study", "by", "performing", "2", "point", "of", "care", "urine", "pregnancy", "tests", "(", "prior", "to", "vaccinations", ")", "\n" ]
[ "Condition", "Procedure", "Observation", "Temporal", "Device", "Drug", "Reference_point", "Person", "Multiplier" ]
Research exemption requested is a Observation, History is a Observation, PCV-13 vaccination is a Procedure, History is a Observation, cochlear implant is a Device, Cerebrospinal Fluid ( CSF ) leak is a Condition, Congestive Heart Failure ( CHF ) is a Condition, Diabetes Mellitus ( DM ) is a Condition, Chronic Kidney Disease ( CKD ) is a Condition, Human Immunodeficiency Virus ( HIV ) is a Condition, Common Variable Immune Deficiency ( CVID ) is a Condition, PPSV23 vaccine is a Drug, in the last 5 years is a Temporal, Women is a Person, pregnant is a Condition, 2 is a Multiplier, point of care urine pregnancy tests is a Procedure, prior to vaccinations is a Temporal
NCT03260790_exc_task1
Sentence: Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations) Instructions: please typing these entity words according to sentence: Research exemption requested, History, PCV-13 vaccination, History, cochlear implant, Cerebrospinal Fluid ( CSF ) leak, Congestive Heart Failure ( CHF ), Diabetes Mellitus ( DM ), Chronic Kidney Disease ( CKD ), Human Immunodeficiency Virus ( HIV ), Common Variable Immune Deficiency ( CVID ), PPSV23 vaccine, in the last 5 years, Women, pregnant, 2, point of care urine pregnancy tests, prior to vaccinations Options: Temporal, Condition, Person, Observation, Multiplier, Procedure, Device, Drug
[ "B-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "O", "B-Procedure", "I-Procedure", "O", "B-Observation", "O", "B-Device", "I-Device", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Person", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multiplier", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O" ]
Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations)
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[ "Condition", "Procedure", "Observation", "Temporal", "Device", "Drug", "Reference_point", "Person", "Multiplier" ]
Research exemption requested, History, PCV-13 vaccination, History, cochlear implant, Cerebrospinal Fluid ( CSF ) leak, Congestive Heart Failure ( CHF ), Diabetes Mellitus ( DM ), Chronic Kidney Disease ( CKD ), Human Immunodeficiency Virus ( HIV ), Common Variable Immune Deficiency ( CVID ), PPSV23 vaccine, in the last 5 years, Women, pregnant, 2, point of care urine pregnancy tests, prior to vaccinations
NCT03260790_exc_task2
Sentence: Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations) Instructions: please extract entity words from the input sentence
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Research exemption requested History of PCV-13 vaccination History of cochlear implant Cerebrospinal Fluid (CSF) leak Congestive Heart Failure (CHF) Diabetes Mellitus (DM) Chronic Kidney Disease (CKD) Human Immunodeficiency Virus (HIV) Common Variable Immune Deficiency (CVID) Patients who have received the PPSV23 vaccine in the last 5 years Women who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations)
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[ "Condition", "Procedure", "Observation", "Temporal", "Device", "Drug", "Reference_point", "Person", "Multiplier" ]
HELLP - Syndrom is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Entbindung is an umlsterm, Diagnosestellung is an umlsterm, Schwangerschaften is an umlsterm, Schwangerschaften is an umlsterm, Glukokortikoide is an umlsterm, Glukokortikoide is an umlsterm, Glukokortikoide is an umlsterm, HELLP - Syndrom is an umlsterm
DerGynaekologe.90320783.ger.abstr_task0
Sentence: Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen .
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[ "umlsterm" ]
HELLP - Syndrom is an umlsterm, Morbiditaet is an umlsterm, Mortalitaet is an umlsterm, Entbindung is an umlsterm, Diagnosestellung is an umlsterm, Schwangerschaften is an umlsterm, Schwangerschaften is an umlsterm, Glukokortikoide is an umlsterm, Glukokortikoide is an umlsterm, Glukokortikoide is an umlsterm, HELLP - Syndrom is an umlsterm
DerGynaekologe.90320783.ger.abstr_task1
Sentence: Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen . Instructions: please typing these entity words according to sentence: HELLP - Syndrom, Morbiditaet, Mortalitaet, Entbindung, Diagnosestellung, Schwangerschaften, Schwangerschaften, Glukokortikoide, Glukokortikoide, Glukokortikoide, HELLP - Syndrom Options: umlsterm
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Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen .
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[ "umlsterm" ]
HELLP - Syndrom, Morbiditaet, Mortalitaet, Entbindung, Diagnosestellung, Schwangerschaften, Schwangerschaften, Glukokortikoide, Glukokortikoide, Glukokortikoide, HELLP - Syndrom
DerGynaekologe.90320783.ger.abstr_task2
Sentence: Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen . Instructions: please extract entity words from the input sentence
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Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbiditaet und Mortalitaet gekennzeichnet . Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert , hat sich bis heute die fruehzeitige Entbindung nach Diagnosestellung durchgesetzt . Nachteil dieses Vorgehens ist die hohe Rate an Fruehgeburtlichkeit vor der 32. SSW . Bisher konnten zwoelf Untersuchungen bei etwa 330 Schwangerschaften zeigen , dass alternativ auch eine Schwangerschaftsverlaengerung - insbesondere bei Schwangerschaften vor der 32. SSW - sinnvoll ist und dadurch eine z . T. erhebliche zusaetzliche intrauterine Reifung erzielt werden kann . Erste Untersuchungen geben Hinweise , dass Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben . In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet , der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen , da auch bei Verzicht komplikationslose Schwangerschaftsverlaengerungen erreicht werden konnten . Es ist somit weder abschliessend geklaert , ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlaengerung auch auf wesentlich groessere Fallzahlen reproduzierbar sind , noch ist sicher zu beantworten , inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen .
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[ "umlsterm" ]
buspirone is a Intervention_Pharmacological, patient with autism . is a Participant_Condition, buspirone hydrochloride is a Intervention_Pharmacological, hyperactivity is a Outcome_Mental, placebo - controlled is a Intervention_Control, placebo for 3 weeks is a Intervention_Control, Conners abbreviated parent and teacher questionnaires is a Outcome_Other, Buspirone is a Intervention_Pharmacological, safe and efficacious is a Outcome_Other, without side effects is a Outcome_Adverse-effects, completed performance tasks is a Outcome_Mental
90168_task0
Sentence: Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Intervention_Control, Participant_Condition, Outcome_Other, Outcome_Mental
[ "O", "O", "B-Intervention_Pharmacological", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed .
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[ "Outcome_Other", "Outcome_Mental", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Intervention_Control" ]
buspirone is a Intervention_Pharmacological, patient with autism . is a Participant_Condition, buspirone hydrochloride is a Intervention_Pharmacological, hyperactivity is a Outcome_Mental, placebo - controlled is a Intervention_Control, placebo for 3 weeks is a Intervention_Control, Conners abbreviated parent and teacher questionnaires is a Outcome_Other, Buspirone is a Intervention_Pharmacological, safe and efficacious is a Outcome_Other, without side effects is a Outcome_Adverse-effects, completed performance tasks is a Outcome_Mental
90168_task1
Sentence: Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed . Instructions: please typing these entity words according to sentence: buspirone, patient with autism ., buspirone hydrochloride, hyperactivity, placebo - controlled, placebo for 3 weeks, Conners abbreviated parent and teacher questionnaires, Buspirone, safe and efficacious, without side effects, completed performance tasks Options: Intervention_Pharmacological, Outcome_Adverse-effects, Intervention_Control, Participant_Condition, Outcome_Other, Outcome_Mental
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Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed .
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[ "Outcome_Other", "Outcome_Mental", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Intervention_Control" ]
buspirone, patient with autism ., buspirone hydrochloride, hyperactivity, placebo - controlled, placebo for 3 weeks, Conners abbreviated parent and teacher questionnaires, Buspirone, safe and efficacious, without side effects, completed performance tasks
90168_task2
Sentence: Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed . Instructions: please extract entity words from the input sentence
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Treatment with buspirone in a patient with autism . This study evaluates the safety and efficacy of buspirone hydrochloride for the treatment of a patient with autism and hyperactivity disorder and determines the effect of buspirone on the number of performance tasks completed by the patient at school . A 3-week , double-blind , placebo-controlled crossover study was performed in a private physician , office-based practice . A child with autism , which was diagnosed by Diagnostic and Statistical Manual of Mental Disorders , Third Edition , Revised , criteria , was studied . The child received placebo for 3 weeks and buspirone for 3 weeks ; there was a 1-week interval between the 2 treatments . The outcome was measured by using Conners abbreviated parent and teacher questionnaires and by determining the number of daily performance tasks completed by the child at school . Statistical analysis was performed by linear models and standard F tests . Buspirone was found to be safe and efficacious , without side effects , for decreasing hyperactivity and increasing completed performance tasks . The beneficial effects of buspirone in helping this patient with autism in his natural daily settings suggest that buspirone may be an alternative to neuroleptic agents in the medical therapy of autism ; further study in other patients is needed .
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[ "Outcome_Other", "Outcome_Mental", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Intervention_Control" ]
Spondylose is an umlsterm, Myelopathie is an umlsterm, radiologisch is an umlsterm, Spinalkanals is an umlsterm, Muskel is an umlsterm, Radikulopathie is an umlsterm, Myelopathie is an umlsterm, Schmerz is an umlsterm, unteren Extremitaeten is an umlsterm, Gangstoerungen is an umlsterm, Muskelatrophien is an umlsterm, oberen Extremitaet is an umlsterm, Hand is an umlsterm, Myelopathie is an umlsterm, unteren Extremitaet is an umlsterm, spastische Paraparese is an umlsterm, Parese is an umlsterm, Hand is an umlsterm, Rueckenmarksyndrom is an umlsterm, Spondylose is an umlsterm, Chirurgie is an umlsterm, Prognose is an umlsterm, Dekompression is an umlsterm
DerOrthopaede.60250496.ger.abstr_task0
Sentence: Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt .
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[ "umlsterm" ]
Spondylose is an umlsterm, Myelopathie is an umlsterm, radiologisch is an umlsterm, Spinalkanals is an umlsterm, Muskel is an umlsterm, Radikulopathie is an umlsterm, Myelopathie is an umlsterm, Schmerz is an umlsterm, unteren Extremitaeten is an umlsterm, Gangstoerungen is an umlsterm, Muskelatrophien is an umlsterm, oberen Extremitaet is an umlsterm, Hand is an umlsterm, Myelopathie is an umlsterm, unteren Extremitaet is an umlsterm, spastische Paraparese is an umlsterm, Parese is an umlsterm, Hand is an umlsterm, Rueckenmarksyndrom is an umlsterm, Spondylose is an umlsterm, Chirurgie is an umlsterm, Prognose is an umlsterm, Dekompression is an umlsterm
DerOrthopaede.60250496.ger.abstr_task1
Sentence: Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt . Instructions: please typing these entity words according to sentence: Spondylose, Myelopathie, radiologisch, Spinalkanals, Muskel, Radikulopathie, Myelopathie, Schmerz, unteren Extremitaeten, Gangstoerungen, Muskelatrophien, oberen Extremitaet, Hand, Myelopathie, unteren Extremitaet, spastische Paraparese, Parese, Hand, Rueckenmarksyndrom, Spondylose, Chirurgie, Prognose, Dekompression Options: umlsterm
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Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt .
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[ "umlsterm" ]
Spondylose, Myelopathie, radiologisch, Spinalkanals, Muskel, Radikulopathie, Myelopathie, Schmerz, unteren Extremitaeten, Gangstoerungen, Muskelatrophien, oberen Extremitaet, Hand, Myelopathie, unteren Extremitaet, spastische Paraparese, Parese, Hand, Rueckenmarksyndrom, Spondylose, Chirurgie, Prognose, Dekompression
DerOrthopaede.60250496.ger.abstr_task2
Sentence: Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt . Instructions: please extract entity words from the input sentence
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Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt . Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veraenderungen zurueckzufuehren . Periphere Symptome wie Radikulopathien koennen hinzukommen , wenn die lateralen Anteile des Spinalkanals eingeengt werden . Die Deltoideusparese Grad = 3 ( MMT ) ist die haeufigste Symptomatik von klinischer Bedeutung , wenn nur ein einzelner Muskel betroffen ist , die von der zervikalspondolytischen Radikulopathie verursacht wird . Bei der zervikalen Myelopathie stehen aber nicht Schmerz sondern Funktionsstoerungen , im Vordergrund . Taubheitsgefuehle an oberen und unteren Extremitaeten sowie Gangstoerungen sind Fruehzeichen . Muskelatrophien werden vor allem an der oberen Extremitaet beobachtet und fuehren haeufig zur sog . myelopathischen Hand . Der zervikale Myelopathie laesst sich in verschiedene Formen unterteilen 1. spastische Tetraparese : mit Symptomen der oberen und unteren Extremitaet , 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus , 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen , 5. zentrales Rueckenmarksyndrom bei zervikaler Spondylose und Traumaanamnese . Therapeutisch sind konservative Massnahmen wenig erfolgversprechend , es empfiehlt sich dekompressive Chirurgie . Die Prognose ist um so besser , je frueher die Dekompression erfolgt .
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[ "umlsterm" ]
sarcopenia is a DISEASE, sarcopenia is a DISEASE, frailty is a DISEASE, disability in aging is a DISEASE, geriatric syndromes is a DISEASE, Sarcopenia is a DISEASE, sarcopenia is a DISEASE, sarcopenia is a DISEASE, insulin resistance is a DISEASE, insulin resistance is a DISEASE, sarcopenia is a DISEASE
example-243_task0
Sentence: Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DISEASE
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Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability.
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[ "DISEASE" ]
sarcopenia is a DISEASE, sarcopenia is a DISEASE, frailty is a DISEASE, disability in aging is a DISEASE, geriatric syndromes is a DISEASE, Sarcopenia is a DISEASE, sarcopenia is a DISEASE, sarcopenia is a DISEASE, insulin resistance is a DISEASE, insulin resistance is a DISEASE, sarcopenia is a DISEASE
example-243_task1
Sentence: Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability. Instructions: please typing these entity words according to sentence: sarcopenia, sarcopenia, frailty, disability in aging, geriatric syndromes, Sarcopenia, sarcopenia, sarcopenia, insulin resistance, insulin resistance, sarcopenia Options: DISEASE
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Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability.
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[ "DISEASE" ]
sarcopenia, sarcopenia, frailty, disability in aging, geriatric syndromes, Sarcopenia, sarcopenia, sarcopenia, insulin resistance, insulin resistance, sarcopenia
example-243_task2
Sentence: Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability. Instructions: please extract entity words from the input sentence
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Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66-84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19-23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor-alpha (TNF-alpha) and a significant increase in both insulin-like growth factor-1 (IGF-1) serum concentrations and in the IGF-1/TNF-alpha ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability.
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[ "DISEASE" ]
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DerUnfallchirurg.01030243.eng.abstr_task0
Sentence: A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer .
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[ "umlsterm" ]
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DerUnfallchirurg.01030243.eng.abstr_task1
Sentence: A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer . Instructions: please typing these entity words according to sentence: old, man, head injury, fracture, skull, subdural hematomas, brain contusion, Abbreviated Injury Scale, hematomas, craniotomy, intracranial pressure, barbiturate, coma, patient, acute lung injury, ARDS, pneumonia, trauma, patient, injury, patient, hip, motion, right, rotation, right, right, X - rays, heterotopic ossification, hips, stage, procedure, prophylaxis, recurrence, single - dose, radiation, postoperative, treatment, indomethacin, patient, hip, right, hip, surgery, hip, movement, right, rotation, right, right, recurrence, patient, profession Options: umlsterm
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A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer .
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[ "umlsterm" ]
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DerUnfallchirurg.01030243.eng.abstr_task2
Sentence: A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer . Instructions: please extract entity words from the input sentence
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A 36-year old man suffered an isolated head injury with a fracture of the skull , epidural and subdural hematomas as well as brain contusion ( Abbreviated Injury Scale ( AIS ) : 5 points ) . The hematomas were evacuated by craniotomy . Because of high intracranial pressure ( ICP ) a barbiturate coma was necessary . Additionally , the patient demonstrated acute lung injury ( ARDS ) due to pneumonia 8 days after trauma . The patient recovered slowly and was transferred to neurorehabilitation on day 57 after injury . During the following 12 months the patient developed a significant deficit of hip motion ( extension/flexion : right : 0 °/10 °/20 ° , left : 0 °/10 °/30 ° ; external/internal rotation : right and left : 5 °/0 °/ 5 ° ; abduction/adduction : right : 10 °/0 °/25 ° , left : 10 °/0 °/10 ° ) . X-rays and CT-scanning revealed severe heterotopic ossification ( HO ) of both hips with ancylosis ( Brooker type IV ) . Resection of HO was carried out in a two stage procedure using Smith-Petersen approach . The prophylaxis for recurrence of HO included preoperative single-dose radiation ( 8 Gy ) and postoperative treatment with indomethacin ( 150 mg per day ) . The patient revealed 15 ( left hip ) and 12 ( right hip ) months after surgery the following range of hip movement : extension/flexion : right : 5 °/0 °/90 ° , left : 5 °/0 °/100 ° ; external/internal rotation : right : 20 °/0 °/30 ° , left : 20 °/0 °/20 ° ; abduction/adduction : right : 30 °/0 °/40 ° , left : 30 °/0 °/40 ° . No recurrence of HO was observed in x-ray . The patient is able to work in his profession as farmer .
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[ "umlsterm" ]
ultraviolet radiation is an umlsterm, Wood is an umlsterm, dermatoses is an umlsterm, fluorescence is an umlsterm, tinea capitis is an umlsterm, erythrasma is an umlsterm, tinea versicolor is an umlsterm, Pseudomonas infections is an umlsterm, medications is an umlsterm, tetracycline is an umlsterm, skin is an umlsterm, fluorescence is an umlsterm, technique is an umlsterm, Wood is an umlsterm, light is an umlsterm, preventive measure is an umlsterm, skin is an umlsterm, workplace is an umlsterm, workers is an umlsterm, occupations is an umlsterm, use is an umlsterm
DerHautarzt.70480523.eng.abstr_task0
Sentence: The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams .
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[ "umlsterm" ]
ultraviolet radiation is an umlsterm, Wood is an umlsterm, dermatoses is an umlsterm, fluorescence is an umlsterm, tinea capitis is an umlsterm, erythrasma is an umlsterm, tinea versicolor is an umlsterm, Pseudomonas infections is an umlsterm, medications is an umlsterm, tetracycline is an umlsterm, skin is an umlsterm, fluorescence is an umlsterm, technique is an umlsterm, Wood is an umlsterm, light is an umlsterm, preventive measure is an umlsterm, skin is an umlsterm, workplace is an umlsterm, workers is an umlsterm, occupations is an umlsterm, use is an umlsterm
DerHautarzt.70480523.eng.abstr_task1
Sentence: The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams . Instructions: please typing these entity words according to sentence: ultraviolet radiation, Wood, dermatoses, fluorescence, tinea capitis, erythrasma, tinea versicolor, Pseudomonas infections, medications, tetracycline, skin, fluorescence, technique, Wood, light, preventive measure, skin, workplace, workers, occupations, use Options: umlsterm
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The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams .
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[ "umlsterm" ]
ultraviolet radiation, Wood, dermatoses, fluorescence, tinea capitis, erythrasma, tinea versicolor, Pseudomonas infections, medications, tetracycline, skin, fluorescence, technique, Wood, light, preventive measure, skin, workplace, workers, occupations, use
DerHautarzt.70480523.eng.abstr_task2
Sentence: The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
The invisible long-wave ultraviolet radiation ( 340-450 nm , max . 365 nm ) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence ( tinea capitis , erythrasma , tinea versicolor , Pseudomonas infections , porphyrians , and pigmentary alterations ) . It is also used in the detection of medications that are taken systemcally ( tetracycline ) or that are applied to the skin . Recently , a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams .
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[ "umlsterm" ]
prostasin is a GENE-Y, alpha - spectrin is a GENE-Y, Nedd4 is a GENE-Y, mineralocorticoid receptor is a GENE-Y, amiloride - sensitive epithelial sodium channel is a GENE-N, ENaC is a GENE-N, alpha - spectrin is a GENE-Y, transmembrane serine proteases is a GENE-N, ubiquitin - protein ligases is a GENE-N, serum- and glucocorticoid - regulated kinases is a GENE-N, sodium is a CHEMICAL, amiloride is a CHEMICAL, prostasin is a GENE-Y
31903_task0
Sentence: Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL, GENE-Y, GENE-N
[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
prostasin is a GENE-Y, alpha - spectrin is a GENE-Y, Nedd4 is a GENE-Y, mineralocorticoid receptor is a GENE-Y, amiloride - sensitive epithelial sodium channel is a GENE-N, ENaC is a GENE-N, alpha - spectrin is a GENE-Y, transmembrane serine proteases is a GENE-N, ubiquitin - protein ligases is a GENE-N, serum- and glucocorticoid - regulated kinases is a GENE-N, sodium is a CHEMICAL, amiloride is a CHEMICAL, prostasin is a GENE-Y
31903_task1
Sentence: Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus. Instructions: please typing these entity words according to sentence: prostasin, alpha - spectrin, Nedd4, mineralocorticoid receptor, amiloride - sensitive epithelial sodium channel, ENaC, alpha - spectrin, transmembrane serine proteases, ubiquitin - protein ligases, serum- and glucocorticoid - regulated kinases, sodium, amiloride, prostasin Options: CHEMICAL, GENE-Y, GENE-N
[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus.
[ "Pseudohypoaldosteronism", "type", "1", "and", "the", "genes", "encoding", "prostasin", ",", "alpha", "-", "spectrin", ",", "and", "Nedd4", ".", "\n", "Pseudohypoaldosteronism", "type", "1", "(", "PHA1", ")", ",", "a", "rare", "disorder", "of", "infancy", ",", "presents", "with", "potential", "life", "-", "threatening", "salt", "wasting", "and", "failure", "to", "thrive", ".", "Thus", "far", ",", "PHA1", "has", "been", "attributed", "to", "mutations", "affecting", "the", "mineralocorticoid", "receptor", "or", "any", "of", "the", "three", "subunits", "assembling", "the", "amiloride", "-", "sensitive", "epithelial", "sodium", "channel", "(", "ENaC", ")", ".", "However", ",", "a", "lot", "of", "patients", "with", "a", "phenotype", "resembling", "PHA1", ",", "show", "no", "defects", "in", "these", "proteins", ",", "making", "it", "likely", "that", "further", "genes", "are", "involved", "in", "the", "aetiology", "of", "this", "disease", ".", "Recent", "studies", "have", "elucidated", "additional", "participants", "(", "alpha", "-", "spectrin", "and", "members", "of", "the", "families", "of", "transmembrane", "serine", "proteases", ",", "ubiquitin", "-", "protein", "ligases", ",", "and", "serum-", "and", "glucocorticoid", "-", "regulated", "kinases", ",", "respectively", ")", "regulating", "and", "/", "or", "interacting", "in", "the", "complex", "pathway", "of", "sodium", "retention", "in", "the", "amiloride", "-", "sensitive", "distal", "nephron", ".", "This", "led", "us", "to", "investigate", "whether", "PHA1", "can", "also", "be", "associated", "with", "mutations", "in", "some", "of", "these", "genes", ".", "Our", "data", "suggest", "that", "at", "least", "the", "prostasin", "gene", "might", "be", "excluded", "as", "a", "causative", "locus", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
prostasin, alpha - spectrin, Nedd4, mineralocorticoid receptor, amiloride - sensitive epithelial sodium channel, ENaC, alpha - spectrin, transmembrane serine proteases, ubiquitin - protein ligases, serum- and glucocorticoid - regulated kinases, sodium, amiloride, prostasin
31903_task2
Sentence: Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. Pseudohypoaldosteronism type 1 (PHA1), a rare disorder of infancy, presents with potential life-threatening salt wasting and failure to thrive. Thus far, PHA1 has been attributed to mutations affecting the mineralocorticoid receptor or any of the three subunits assembling the amiloride-sensitive epithelial sodium channel (ENaC). However, a lot of patients with a phenotype resembling PHA1, show no defects in these proteins, making it likely that further genes are involved in the aetiology of this disease. Recent studies have elucidated additional participants (alpha-spectrin and members of the families of transmembrane serine proteases, ubiquitin-protein ligases, and serum- and glucocorticoid-regulated kinases, respectively) regulating and/or interacting in the complex pathway of sodium retention in the amiloride-sensitive distal nephron. This led us to investigate whether PHA1 can also be associated with mutations in some of these genes. Our data suggest that at least the prostasin gene might be excluded as a causative locus.
[ "Pseudohypoaldosteronism", "type", "1", "and", "the", "genes", "encoding", "prostasin", ",", "alpha", "-", "spectrin", ",", "and", "Nedd4", ".", "\n", "Pseudohypoaldosteronism", "type", "1", "(", "PHA1", ")", ",", "a", "rare", "disorder", "of", "infancy", ",", "presents", "with", "potential", "life", "-", "threatening", "salt", "wasting", "and", "failure", "to", "thrive", ".", "Thus", "far", ",", "PHA1", "has", "been", "attributed", "to", "mutations", "affecting", "the", "mineralocorticoid", "receptor", "or", "any", "of", "the", "three", "subunits", "assembling", "the", "amiloride", "-", "sensitive", "epithelial", "sodium", "channel", "(", "ENaC", ")", ".", "However", ",", "a", "lot", "of", "patients", "with", "a", "phenotype", "resembling", "PHA1", ",", "show", "no", "defects", "in", "these", "proteins", ",", "making", "it", "likely", "that", "further", "genes", "are", "involved", "in", "the", "aetiology", "of", "this", "disease", ".", "Recent", "studies", "have", "elucidated", "additional", "participants", "(", "alpha", "-", "spectrin", "and", "members", "of", "the", "families", "of", "transmembrane", "serine", "proteases", ",", "ubiquitin", "-", "protein", "ligases", ",", "and", "serum-", "and", "glucocorticoid", "-", "regulated", "kinases", ",", "respectively", ")", "regulating", "and", "/", "or", "interacting", "in", "the", "complex", "pathway", "of", "sodium", "retention", "in", "the", "amiloride", "-", "sensitive", "distal", "nephron", ".", "This", "led", "us", "to", "investigate", "whether", "PHA1", "can", "also", "be", "associated", "with", "mutations", "in", "some", "of", "these", "genes", ".", "Our", "data", "suggest", "that", "at", "least", "the", "prostasin", "gene", "might", "be", "excluded", "as", "a", "causative", "locus", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
titanium is a compound, calcium phosphate is a compound, matrix protein is a protein
DS.d792_task0
Sentence: Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O" ]
Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen.
[ "Osteointegration", "of", "titanium", "or", "its", "alloy", "with", "bone", "can", "be", "greatly", "improved", "by", "calcium", "phosphate", "coatings", ",", "and", "further", "enhanced", "by", "an", "extracellular", "matrix", "protein", "layer", "such", "as", "collagen", "." ]
[ "compound", "protein" ]
titanium is a compound, calcium phosphate is a compound, matrix protein is a protein
DS.d792_task1
Sentence: Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen. Instructions: please typing these entity words according to sentence: titanium, calcium phosphate, matrix protein Options: compound, protein
[ "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O" ]
Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen.
[ "Osteointegration", "of", "titanium", "or", "its", "alloy", "with", "bone", "can", "be", "greatly", "improved", "by", "calcium", "phosphate", "coatings", ",", "and", "further", "enhanced", "by", "an", "extracellular", "matrix", "protein", "layer", "such", "as", "collagen", "." ]
[ "compound", "protein" ]
titanium, calcium phosphate, matrix protein
DS.d792_task2
Sentence: Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O" ]
Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen.
[ "Osteointegration", "of", "titanium", "or", "its", "alloy", "with", "bone", "can", "be", "greatly", "improved", "by", "calcium", "phosphate", "coatings", ",", "and", "further", "enhanced", "by", "an", "extracellular", "matrix", "protein", "layer", "such", "as", "collagen", "." ]
[ "compound", "protein" ]
male is an umlsterm, patient is an umlsterm, giant cells is an umlsterm, granuloma annulare is an umlsterm, association is an umlsterm, diabetes is an umlsterm
DerHautarzt.60470053.eng.abstr_task0
Sentence: We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]
We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus .
[ "We", "report", "on", "a", "56-year", "-", "old", "male", "patient", "with", "annular", ",", "erythematous", "and", "slightly", "elevated", "lesions", "measuring", "up", "to", "12", "cm", "in", "diameter", "on", "the", "trunk", ".", "Histologically", "a", "diffuse", "mononuclear", "infiltrate", "with", "histiocytic", "giant", "cells", "was", "present", ".", "His", "condition", "is", "a", "rare", "variant", "of", "generalized", "granuloma", "annulare", "in", "association", "with", "diabetes", "mellitus", "." ]
[ "umlsterm" ]
male is an umlsterm, patient is an umlsterm, giant cells is an umlsterm, granuloma annulare is an umlsterm, association is an umlsterm, diabetes is an umlsterm
DerHautarzt.60470053.eng.abstr_task1
Sentence: We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus . Instructions: please typing these entity words according to sentence: male, patient, giant cells, granuloma annulare, association, diabetes Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]
We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus .
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[ "umlsterm" ]
male, patient, giant cells, granuloma annulare, association, diabetes
DerHautarzt.60470053.eng.abstr_task2
Sentence: We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]
We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus .
[ "We", "report", "on", "a", "56-year", "-", "old", "male", "patient", "with", "annular", ",", "erythematous", "and", "slightly", "elevated", "lesions", "measuring", "up", "to", "12", "cm", "in", "diameter", "on", "the", "trunk", ".", "Histologically", "a", "diffuse", "mononuclear", "infiltrate", "with", "histiocytic", "giant", "cells", "was", "present", ".", "His", "condition", "is", "a", "rare", "variant", "of", "generalized", "granuloma", "annulare", "in", "association", "with", "diabetes", "mellitus", "." ]
[ "umlsterm" ]
Emergency medicine is an umlsterm, critical care is an umlsterm, diagnosis is an umlsterm, tachycardia is an umlsterm, faster is an umlsterm, Causes is an umlsterm, tachycardia is an umlsterm, sinus tachycardia is an umlsterm, tachycardia is an umlsterm, tachycardia is an umlsterm, movement is an umlsterm, tachycardia is an umlsterm, atrial flutter is an umlsterm, atrial fibrillation is an umlsterm, systematic is an umlsterm, ECG is an umlsterm, evaluation is an umlsterm, AV block is an umlsterm, identification is an umlsterm, arrhythmia is an umlsterm, origin is an umlsterm, arrhythmia is an umlsterm, cardioversion is an umlsterm, hemodynamic is an umlsterm, sinus is an umlsterm, massage is an umlsterm, drugs is an umlsterm, therapeutic is an umlsterm, metoprolol is an umlsterm, adenosine is an umlsterm, ajmaline is an umlsterm, patients is an umlsterm, ajmaline is an umlsterm, drug is an umlsterm, pharmacologic is an umlsterm, cardioversion is an umlsterm, therapy is an umlsterm, sinus is an umlsterm, control is an umlsterm, Direct is an umlsterm, cardioversion is an umlsterm, sinus is an umlsterm, single is an umlsterm, drug is an umlsterm, choice is an umlsterm, propafenone is an umlsterm, flecainide is an umlsterm, sotalol is an umlsterm, control is an umlsterm, Verapamil is an umlsterm, digoxin is an umlsterm, drugs is an umlsterm, treatment is an umlsterm, pacing is an umlsterm, cardioversion is an umlsterm, administration is an umlsterm, propafenone is an umlsterm, flecainide is an umlsterm
IntensiveMedizin.00370631.eng.abstr_task0
Sentence: Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) .
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[ "umlsterm" ]
Emergency medicine is an umlsterm, critical care is an umlsterm, diagnosis is an umlsterm, tachycardia is an umlsterm, faster is an umlsterm, Causes is an umlsterm, tachycardia is an umlsterm, sinus tachycardia is an umlsterm, tachycardia is an umlsterm, tachycardia is an umlsterm, movement is an umlsterm, tachycardia is an umlsterm, atrial flutter is an umlsterm, atrial fibrillation is an umlsterm, systematic is an umlsterm, ECG is an umlsterm, evaluation is an umlsterm, AV block is an umlsterm, identification is an umlsterm, arrhythmia is an umlsterm, origin is an umlsterm, arrhythmia is an umlsterm, cardioversion is an umlsterm, hemodynamic is an umlsterm, sinus is an umlsterm, massage is an umlsterm, drugs is an umlsterm, therapeutic is an umlsterm, metoprolol is an umlsterm, adenosine is an umlsterm, ajmaline is an umlsterm, patients is an umlsterm, ajmaline is an umlsterm, drug is an umlsterm, pharmacologic is an umlsterm, cardioversion is an umlsterm, therapy is an umlsterm, sinus is an umlsterm, control is an umlsterm, Direct is an umlsterm, cardioversion is an umlsterm, sinus is an umlsterm, single is an umlsterm, drug is an umlsterm, choice is an umlsterm, propafenone is an umlsterm, flecainide is an umlsterm, sotalol is an umlsterm, control is an umlsterm, Verapamil is an umlsterm, digoxin is an umlsterm, drugs is an umlsterm, treatment is an umlsterm, pacing is an umlsterm, cardioversion is an umlsterm, administration is an umlsterm, propafenone is an umlsterm, flecainide is an umlsterm
IntensiveMedizin.00370631.eng.abstr_task1
Sentence: Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) . Instructions: please typing these entity words according to sentence: Emergency medicine, critical care, diagnosis, tachycardia, faster, Causes, tachycardia, sinus tachycardia, tachycardia, tachycardia, movement, tachycardia, atrial flutter, atrial fibrillation, systematic, ECG, evaluation, AV block, identification, arrhythmia, origin, arrhythmia, cardioversion, hemodynamic, sinus, massage, drugs, therapeutic, metoprolol, adenosine, ajmaline, patients, ajmaline, drug, pharmacologic, cardioversion, therapy, sinus, control, Direct, cardioversion, sinus, single, drug, choice, propafenone, flecainide, sotalol, control, Verapamil, digoxin, drugs, treatment, pacing, cardioversion, administration, propafenone, flecainide Options: umlsterm
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Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) .
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[ "umlsterm" ]
Emergency medicine, critical care, diagnosis, tachycardia, faster, Causes, tachycardia, sinus tachycardia, tachycardia, tachycardia, movement, tachycardia, atrial flutter, atrial fibrillation, systematic, ECG, evaluation, AV block, identification, arrhythmia, origin, arrhythmia, cardioversion, hemodynamic, sinus, massage, drugs, therapeutic, metoprolol, adenosine, ajmaline, patients, ajmaline, drug, pharmacologic, cardioversion, therapy, sinus, control, Direct, cardioversion, sinus, single, drug, choice, propafenone, flecainide, sotalol, control, Verapamil, digoxin, drugs, treatment, pacing, cardioversion, administration, propafenone, flecainide
IntensiveMedizin.00370631.eng.abstr_task2
Sentence: Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) . Instructions: please extract entity words from the input sentence
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Emergency medicine and critical care are fields that often require rapid diagnosis and intervention for specific situations . Narrow QRS tachycardia is a cardiac rhythm with a rate faster than 100/min and a QRS duration 0.12 s. Causes of narrow QRS tachycardia ( N-QRS-T ) are sinus tachycardia ( ST ) , atrial tachycardia ( AT ) , AV nodal reentry tachycardia ( AVNRT ) , circus movement tachycardia ( CMT ) , atrial flutter ( AFlut ) and atrial fibrillation ( AFib ) . A systematic ECG approach with evaluation of spontaneous AV block , QRS alternans , P wave location and P wave polarity permits correct identification of the underlying arrhythmia mechanism and the origin of the arrhythmia . In hemodynamically unstable N-QRS-T , electrical DC cardioversion should be performed immediately . If the hemodynamic situation is stable , vagal maneuvers ( Valsalva , carotis sinus massage ) are indicated ; if unsuccessful , drugs are therapeutic alternatives . In ST , beta-blocking agents ( metoprolol 15 mg i.v. ) are successful ; in AT and AVNRT adenosine ( 6-18 mg bolus i.v. ) and ajmaline ( 50-100 mg i.v. ) are preferred . In patients ( pts ) with CMT , ajmaline ( 50-100 mg i.v. ) is an ideal drug with high success rates . When vagal maneuvers or pharmacologic interventions fail to suppress the N-QRS-T , DC cardioversion is necessary . For pts with AFib principles of therapy are restoration of sinus rhythm ( RSR ) or ventricular rate control . Direct current cardioversion can restore sinus rhythm in up to 90% of pts with AFib . No single agent has emerged as the drug of choice for converting AFib ; however , RSR is possible with propafenone ( 600 mg oral ) , flecainide ( 300mg oral ) or sotalol ( 80-160 mg oral ) . Ventricular rate control is an important component in pts with AFib . Verapamil ( 5-10 mg i.v. ) and digoxin ( 0.4 mg i.v. ) are effective drugs in reducing resting ventricular rates in pts with established AFib . Three options are available for acute treatment of AFlut : rapid atrial pacing , DC cardioversion or administration of propafenone ( 600 mg oral ) or flecainide ( 300 mg oral ) .
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[ "umlsterm" ]
Gelenkinfektionen is an umlsterm, Salmonellosen is an umlsterm, Gewebeschaedigungen is an umlsterm, Infektionen is an umlsterm, alkoholabhaengigen is an umlsterm, Boden is an umlsterm, Knochennekrose is an umlsterm, Gelenks is an umlsterm, Knorpel is an umlsterm, Knochen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Salmonellenarthritis is an umlsterm, Literatur is an umlsterm, Knochenbiopsie is an umlsterm, Kommunikation is an umlsterm
DerUnfallchirurg.91020967.ger.abstr_task0
Sentence: Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen .
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[ "umlsterm" ]
Gelenkinfektionen is an umlsterm, Salmonellosen is an umlsterm, Gewebeschaedigungen is an umlsterm, Infektionen is an umlsterm, alkoholabhaengigen is an umlsterm, Boden is an umlsterm, Knochennekrose is an umlsterm, Gelenks is an umlsterm, Knorpel is an umlsterm, Knochen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Salmonellenarthritis is an umlsterm, Literatur is an umlsterm, Knochenbiopsie is an umlsterm, Kommunikation is an umlsterm
DerUnfallchirurg.91020967.ger.abstr_task1
Sentence: Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen . Instructions: please typing these entity words according to sentence: Gelenkinfektionen, Salmonellosen, Gewebeschaedigungen, Infektionen, alkoholabhaengigen, Boden, Knochennekrose, Gelenks, Knorpel, Knochen, Diagnostik, Therapie, Salmonellenarthritis, Literatur, Knochenbiopsie, Kommunikation Options: umlsterm
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Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen .
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[ "umlsterm" ]
Gelenkinfektionen, Salmonellosen, Gewebeschaedigungen, Infektionen, alkoholabhaengigen, Boden, Knochennekrose, Gelenks, Knorpel, Knochen, Diagnostik, Therapie, Salmonellenarthritis, Literatur, Knochenbiopsie, Kommunikation
DerUnfallchirurg.91020967.ger.abstr_task2
Sentence: Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen . Instructions: please extract entity words from the input sentence
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Sekundaere haematogene Gelenkinfektionen werden bei weniger als 1 % aller systemischen Salmonellosen beobachtet . Lokale Gewebeschaedigungen oder systemische Grunderkrankungen beguenstigen das Zustandekommen dieser atypischen Infektionen . Wir stellen den Fall einer alkoholabhaengigen Patientin dar , bei welcher eine Salmonellenkoxitis auf dem Boden einer ischaemischen Knochennekrose des Hueftkopfes entstand . Die weit fortgeschrittene Zerstoerung des Gelenks erforderte eine Resektionsarthroplastik . Histologisch fand sich eine destruierende Invasion von Knorpel und spongioesem Knochen durch zellreiches Entzuendungsgewebe . In Unkenntnis des bakteriologischen Befundes war zunaechst der Verdacht auf eine neoplastische Veraenderung geaeussert worden . Entstehung Verlauf , Diagnostik und Therapie , der Salmonellenarthritis werden anhand dieses Falles und der Literatur diskutiert . Die erfolgreiche Befundung einer Knochenbiopsie ist auf eine gute Kommunikation zwischen Kliniker und Pathologe angewiesen .
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[ "umlsterm" ]
Patienten is an umlsterm, Atherosklerose is an umlsterm, Herzerkrankung is an umlsterm, Aortenaneurysma is an umlsterm, Nierenarterienstenose is an umlsterm, Aneurysma is an umlsterm, Arteria subclavia is an umlsterm, Verlaufsbeobachtung is an umlsterm, Langzeitergebnis is an umlsterm, Aneurysma is an umlsterm, Kontroll - Computertomographie is an umlsterm, Ultraschall is an umlsterm, Stents is an umlsterm
ZfuerKardiologie.00890761.ger.abstr_task0
Sentence: Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents .
[ "Bei", "einem", "73-jaehrigen", "Patienten", "mit", "generalisierter", "Atherosklerose", ",", "koronarer", "Herzerkrankung", ",", "abdominellem", "Aortenaneurysma", "sowie", "Nierenarterienstenose", "konnte", "ein", "abgangsnahes", "Aneurysma", "der", "linken", "Arteria", "subclavia", "mittels", "Implantation", "eines", "ballonexpandierbaren", "JOSTENT", "©", "-Peripheral", "Stent", "-", "Grafts", "erfolgreich", "ausgeschaltet", "werden", ".", "Die", "Verlaufsbeobachtung", "ueber", "ein", "Jahr", "zeigte", "ein", "sehr", "gutes", "Langzeitergebnis", "bei", "frei", "perfundiertem", "Stentlumen", "und", "vollstaendig", "ausgeschaltetem", "Aneurysma", ".", "In", "einer", "Kontroll", "-", "Computertomographie", "fand", "sich", "ein", "vollstaendig", "thrombosierter", "Aneurysmasack", ".", "Im", "intravaskulaeren", "Ultraschall", "fand", "sich", "kein", "Hinweis", "auf", "eine", "Neointimahyperplasie", "innerhalb", "des", "Stents", "." ]
[ "umlsterm" ]
Patienten is an umlsterm, Atherosklerose is an umlsterm, Herzerkrankung is an umlsterm, Aortenaneurysma is an umlsterm, Nierenarterienstenose is an umlsterm, Aneurysma is an umlsterm, Arteria subclavia is an umlsterm, Verlaufsbeobachtung is an umlsterm, Langzeitergebnis is an umlsterm, Aneurysma is an umlsterm, Kontroll - Computertomographie is an umlsterm, Ultraschall is an umlsterm, Stents is an umlsterm
ZfuerKardiologie.00890761.ger.abstr_task1
Sentence: Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents . Instructions: please typing these entity words according to sentence: Patienten, Atherosklerose, Herzerkrankung, Aortenaneurysma, Nierenarterienstenose, Aneurysma, Arteria subclavia, Verlaufsbeobachtung, Langzeitergebnis, Aneurysma, Kontroll - Computertomographie, Ultraschall, Stents Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents .
[ "Bei", "einem", "73-jaehrigen", "Patienten", "mit", "generalisierter", "Atherosklerose", ",", "koronarer", "Herzerkrankung", ",", "abdominellem", "Aortenaneurysma", "sowie", "Nierenarterienstenose", "konnte", "ein", "abgangsnahes", "Aneurysma", "der", "linken", "Arteria", "subclavia", "mittels", "Implantation", "eines", "ballonexpandierbaren", "JOSTENT", "©", "-Peripheral", "Stent", "-", "Grafts", "erfolgreich", "ausgeschaltet", "werden", ".", "Die", "Verlaufsbeobachtung", "ueber", "ein", "Jahr", "zeigte", "ein", "sehr", "gutes", "Langzeitergebnis", "bei", "frei", "perfundiertem", "Stentlumen", "und", "vollstaendig", "ausgeschaltetem", "Aneurysma", ".", "In", "einer", "Kontroll", "-", "Computertomographie", "fand", "sich", "ein", "vollstaendig", "thrombosierter", "Aneurysmasack", ".", "Im", "intravaskulaeren", "Ultraschall", "fand", "sich", "kein", "Hinweis", "auf", "eine", "Neointimahyperplasie", "innerhalb", "des", "Stents", "." ]
[ "umlsterm" ]
Patienten, Atherosklerose, Herzerkrankung, Aortenaneurysma, Nierenarterienstenose, Aneurysma, Arteria subclavia, Verlaufsbeobachtung, Langzeitergebnis, Aneurysma, Kontroll - Computertomographie, Ultraschall, Stents
ZfuerKardiologie.00890761.ger.abstr_task2
Sentence: Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Bei einem 73-jaehrigen Patienten mit generalisierter Atherosklerose , koronarer Herzerkrankung , abdominellem Aortenaneurysma sowie Nierenarterienstenose konnte ein abgangsnahes Aneurysma der linken Arteria subclavia mittels Implantation eines ballonexpandierbaren JOSTENT©-Peripheral Stent-Grafts erfolgreich ausgeschaltet werden . Die Verlaufsbeobachtung ueber ein Jahr zeigte ein sehr gutes Langzeitergebnis bei frei perfundiertem Stentlumen und vollstaendig ausgeschaltetem Aneurysma . In einer Kontroll-Computertomographie fand sich ein vollstaendig thrombosierter Aneurysmasack . Im intravaskulaeren Ultraschall fand sich kein Hinweis auf eine Neointimahyperplasie innerhalb des Stents .
[ "Bei", "einem", "73-jaehrigen", "Patienten", "mit", "generalisierter", "Atherosklerose", ",", "koronarer", "Herzerkrankung", ",", "abdominellem", "Aortenaneurysma", "sowie", "Nierenarterienstenose", "konnte", "ein", "abgangsnahes", "Aneurysma", "der", "linken", "Arteria", "subclavia", "mittels", "Implantation", "eines", "ballonexpandierbaren", "JOSTENT", "©", "-Peripheral", "Stent", "-", "Grafts", "erfolgreich", "ausgeschaltet", "werden", ".", "Die", "Verlaufsbeobachtung", "ueber", "ein", "Jahr", "zeigte", "ein", "sehr", "gutes", "Langzeitergebnis", "bei", "frei", "perfundiertem", "Stentlumen", "und", "vollstaendig", "ausgeschaltetem", "Aneurysma", ".", "In", "einer", "Kontroll", "-", "Computertomographie", "fand", "sich", "ein", "vollstaendig", "thrombosierter", "Aneurysmasack", ".", "Im", "intravaskulaeren", "Ultraschall", "fand", "sich", "kein", "Hinweis", "auf", "eine", "Neointimahyperplasie", "innerhalb", "des", "Stents", "." ]
[ "umlsterm" ]
effectiveness is a Outcome_Other, One group received computer - generated , customized letters explaining recommended preventive procedures for each family member . is a Intervention_Educational, A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups is a Intervention_Other, A third group ( control group ) received no letters . is a Intervention_Control, 8770 is a Participant_Sample-size, 719 is a Participant_Sample-size, The Family Received Index is a Outcome_Physical, Family End - of - study Up - to - date Index is a Outcome_Physical, Family End - of - study Up - to - date indices is a Outcome_Physical, form - letter is a Intervention_Other, customizing reminder letters . is a Intervention_Educational
91327_task0
Sentence: Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Intervention_Educational, Intervention_Other, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters .
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[ "Intervention_Educational", "Intervention_Other", "Intervention_Control", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size" ]
effectiveness is a Outcome_Other, One group received computer - generated , customized letters explaining recommended preventive procedures for each family member . is a Intervention_Educational, A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups is a Intervention_Other, A third group ( control group ) received no letters . is a Intervention_Control, 8770 is a Participant_Sample-size, 719 is a Participant_Sample-size, The Family Received Index is a Outcome_Physical, Family End - of - study Up - to - date Index is a Outcome_Physical, Family End - of - study Up - to - date indices is a Outcome_Physical, form - letter is a Intervention_Other, customizing reminder letters . is a Intervention_Educational
91327_task1
Sentence: Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters . Instructions: please typing these entity words according to sentence: effectiveness, One group received computer - generated , customized letters explaining recommended preventive procedures for each family member ., A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups, A third group ( control group ) received no letters ., 8770, 719, The Family Received Index, Family End - of - study Up - to - date Index, Family End - of - study Up - to - date indices, form - letter, customizing reminder letters . Options: Intervention_Control, Intervention_Educational, Intervention_Other, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational" ]
Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters .
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[ "Intervention_Educational", "Intervention_Other", "Intervention_Control", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size" ]
effectiveness, One group received computer - generated , customized letters explaining recommended preventive procedures for each family member ., A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups, A third group ( control group ) received no letters ., 8770, 719, The Family Received Index, Family End - of - study Up - to - date Index, Family End - of - study Up - to - date indices, form - letter, customizing reminder letters .
91327_task2
Sentence: Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters . Instructions: please extract entity words from the input sentence
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Randomized controlled study of customized preventive medicine reminder letters in a community practice . OBJECTIVE To test the effectiveness of customized , family-oriented reminder letters in activating patients to seek appropriate preventive services . DESIGN Randomized clinical trial . One group received computer-generated , customized letters explaining recommended preventive procedures for each family member . A second group received a form letter listing recommendations for all preventive procedures for all age and sex groups . A third group ( control group ) received no letters . SETTING A private medical centre , without university affiliation , in rural Quebec . PARTICIPANTS From 8770 patients who met study criteria , 719 families were randomly selected . Data were available for 1971 of 1998 patients in these families . MAIN OUTCOME MEASURES The Family Received Index is the proportion of all procedures for which a family was overdue that they received . The Family End-of-study Up-to-date Index is the proportion of procedures for which the family was eligible and for which they were up-to-date at the end of the study . RESULTS The Family Received Index for families mailed customized letters was more than double the index for patients not mailed letters ( Kruskal-Wallis P = .0139 ) . Comparison of the Family End-of-study Up-to-date indices also demonstrated that families of patients sent customized letters were more likely to be up-to-date than families not sent letters ( Kruskal-Wallis P = .0054 ) . No statistically significant difference appeared between the number of preventive measures received by the control group and the form-letter group . CONCLUSIONS This study demonstrates a clinically small but statistically significant value to customizing reminder letters .
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[ "Intervention_Educational", "Intervention_Other", "Intervention_Control", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size" ]
Id3 is a Protein, Id3 is a Protein, Id3 is a Protein, Id3 is a Protein, Id3 is a Protein
177_task0
Sentence: Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.
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[ "Protein" ]
Id3 is a Protein, Id3 is a Protein, Id3 is a Protein, Id3 is a Protein, Id3 is a Protein
177_task1
Sentence: Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint. Instructions: please typing these entity words according to sentence: Id3, Id3, Id3, Id3, Id3 Options: Protein
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Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.
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[ "Protein" ]
Id3, Id3, Id3, Id3, Id3
177_task2
Sentence: Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint. Instructions: please extract entity words from the input sentence
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Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC). Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells. Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA. These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells. We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC. These cells had properties of both natural killer (NK) and pre-T cells. These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.
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[ "Protein" ]
power asymmetries is a Participant_Condition, cooperation and punishment in a prisoner ' s dilemma game is a Outcome_Other, iterated prisoner ' s dilemma game with punishment . is a Intervention_Educational, two - player game is a Intervention_Educational
69932_task0
Sentence: The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Outcome_Other, Participant_Condition
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The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games .
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[ "Outcome_Other", "Intervention_Educational", "Participant_Condition" ]
power asymmetries is a Participant_Condition, cooperation and punishment in a prisoner ' s dilemma game is a Outcome_Other, iterated prisoner ' s dilemma game with punishment . is a Intervention_Educational, two - player game is a Intervention_Educational
69932_task1
Sentence: The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games . Instructions: please typing these entity words according to sentence: power asymmetries, cooperation and punishment in a prisoner ' s dilemma game, iterated prisoner ' s dilemma game with punishment ., two - player game Options: Intervention_Educational, Outcome_Other, Participant_Condition
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The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games .
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[ "Outcome_Other", "Intervention_Educational", "Participant_Condition" ]
power asymmetries, cooperation and punishment in a prisoner ' s dilemma game, iterated prisoner ' s dilemma game with punishment ., two - player game
69932_task2
Sentence: The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games . Instructions: please extract entity words from the input sentence
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The effect of power asymmetries on cooperation and punishment in a prisoner 's dilemma game . Recent work has suggested that punishment is detrimental because punishment provokes retaliation , not cooperation , resulting in lower overall payoffs . These findings may stem from the unrealistic assumption that all players are equal : in reality individuals are expected to vary in the power with which they can punish defectors . Here , we allowed strong players to interact with weak players in an iterated prisoner 's dilemma game with punishment . Defecting players were most likely to switch to cooperation if the partner cooperated : adding punishment yielded no additional benefit and , under some circumstances , increased the chance that the partner would both defect and retaliate against the punisher . Our findings show that , in a two-player game , cooperation begets cooperation and that punishment does not seem to yield any additional benefits . Further work should explore whether strong punishers might prevail in multi-player games .
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[ "Outcome_Other", "Intervention_Educational", "Participant_Condition" ]
significant painful episodes is an outcome, febrile illness is an outcome, admission rate is an outcome
1449_task0
Sentence: Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: outcome
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Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) .
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[ "outcome" ]
significant painful episodes is an outcome, febrile illness is an outcome, admission rate is an outcome
1449_task1
Sentence: Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) . Instructions: please typing these entity words according to sentence: significant painful episodes, febrile illness, admission rate Options: outcome
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) .
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[ "outcome" ]
significant painful episodes, febrile illness, admission rate
1449_task2
Sentence: Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) . Instructions: please extract entity words from the input sentence
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Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) .
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[ "outcome" ]
erectile dysfunction is a DISEASE
example-368_task0
Sentence: Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DISEASE
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Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r.
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[ "DISEASE" ]
erectile dysfunction is a DISEASE
example-368_task1
Sentence: Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r. Instructions: please typing these entity words according to sentence: erectile dysfunction Options: DISEASE
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Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r.
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[ "DISEASE" ]
erectile dysfunction
example-368_task2
Sentence: Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r. Instructions: please extract entity words from the input sentence
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Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. BACKGROUND AND OBJECTIVES: Darunavir (DRV, TMC114) is a novel protease inhibitor administered in combination with low-dose ritonavir (DRV/r) and is highly active against both wild-type and multidrug-resistant HIV-1 strains. Sildenafil is an oral therapy for erectile dysfunction. Concomitant administration of protease inhibitors and sildenafil increases sildenafil plasma concentrations. The potential for a pharmacokinetic drug interaction exists when sildenafil and DRV/r are co-administered, as these drugs are primarily metabolized by cytochrome P450 (CYP) 3A, and darunavir and ritonavir are CYP3A inhibitors. The primary objective of this open-label, crossover, phase I study was to assess the effect of multiple doses of DRV/r on the pharmacokinetics of sildenafil and its active metabolite N-desmethyl sildenafil. The secondary objective was to assess the short-term safety and tolerability of co-administration of sildenafil and DRV/r. METHODS: Sixteen HIV-negative healthy male subjects were randomized to one of two sequences. In two sessions each subject received treatments A and B. In treatment A, a single dose of sildenafil 100 mg was administered. In treatment B, the subjects received DRV/r 400/100 mg twice daily for 8 days and on day 7 a single dose of sildenafil 25 mg was co-administered. Full pharmacokinetic profiles of sildenafil, N-desmethyl sildenafil, darunavir and ritonavir were determined. Safety and tolerability were also assessed. RESULTS: Sildenafil exposure (area under the plasma concentration-time curve [AUC]) was comparable between the two treatments despite administration of a lower dose of sildenafil (25 mg) with DRV/r than when sildenafil (100 mg) was administered alone. When sildenafil 25 mg was co-administered with DRV/r, the sildenafil maximum plasma concentration (Cmax) was 38% lower compared with Cmax after administration of sildenafil alone at a dose of 100 mg. N-desmethyl sildenafil Cmax and AUC from the time of administration until the last time point with a measurable concentration after dosing (calculated by linear trapezoidal summation [AUClast]) values decreased by approximately 95% when sildenafil 25 mg was co-administered with DRV/r compared with sildenafil 100 mg alone. Combined treatment with DRV/r and sildenafil was generally safe and well tolerated. CONCLUSION: Sildenafil exposure is increased in the presence of DRV/r. In this setting, a dose adjustment for sildenafil is warranted; no more than 25 mg of sildenafil is recommended over a 48-hour period when co-administered with DRV/r.
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[ "DISEASE" ]
Unfaelle is an umlsterm, Deutschland is an umlsterm, Todesursache is an umlsterm, Patienten is an umlsterm, Volumentherapie is an umlsterm, Herzzeitvolumens is an umlsterm, Sauerstoffangebot is an umlsterm, Gewebe is an umlsterm, Element is an umlsterm, Trauma is an umlsterm, Blutdruck is an umlsterm, Herzzeitvolumen is an umlsterm, Perfusion is an umlsterm, Volumentherapie is an umlsterm, Kolloiden is an umlsterm, Koerpergewicht is an umlsterm, Kochsalz - Kolloidloesung is an umlsterm, Standardtherapie is an umlsterm, Sauerstofftraegerloesungen is an umlsterm, Blut is an umlsterm, Sauerstoffverfuegbarkeit is an umlsterm, Gewebe is an umlsterm
DerAnaesthesist.60450884.ger.abstr_task0
Sentence: Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern .
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[ "umlsterm" ]
Unfaelle is an umlsterm, Deutschland is an umlsterm, Todesursache is an umlsterm, Patienten is an umlsterm, Volumentherapie is an umlsterm, Herzzeitvolumens is an umlsterm, Sauerstoffangebot is an umlsterm, Gewebe is an umlsterm, Element is an umlsterm, Trauma is an umlsterm, Blutdruck is an umlsterm, Herzzeitvolumen is an umlsterm, Perfusion is an umlsterm, Volumentherapie is an umlsterm, Kolloiden is an umlsterm, Koerpergewicht is an umlsterm, Kochsalz - Kolloidloesung is an umlsterm, Standardtherapie is an umlsterm, Sauerstofftraegerloesungen is an umlsterm, Blut is an umlsterm, Sauerstoffverfuegbarkeit is an umlsterm, Gewebe is an umlsterm
DerAnaesthesist.60450884.ger.abstr_task1
Sentence: Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern . Instructions: please typing these entity words according to sentence: Unfaelle, Deutschland, Todesursache, Patienten, Volumentherapie, Herzzeitvolumens, Sauerstoffangebot, Gewebe, Element, Trauma, Blutdruck, Herzzeitvolumen, Perfusion, Volumentherapie, Kolloiden, Koerpergewicht, Kochsalz - Kolloidloesung, Standardtherapie, Sauerstofftraegerloesungen, Blut, Sauerstoffverfuegbarkeit, Gewebe Options: umlsterm
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Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern .
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[ "umlsterm" ]
Unfaelle, Deutschland, Todesursache, Patienten, Volumentherapie, Herzzeitvolumens, Sauerstoffangebot, Gewebe, Element, Trauma, Blutdruck, Herzzeitvolumen, Perfusion, Volumentherapie, Kolloiden, Koerpergewicht, Kochsalz - Kolloidloesung, Standardtherapie, Sauerstofftraegerloesungen, Blut, Sauerstoffverfuegbarkeit, Gewebe
DerAnaesthesist.60450884.ger.abstr_task2
Sentence: Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern . Instructions: please extract entity words from the input sentence
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Zusammenfassung Unfaelle und verletzungsbedingte grosse Blutverluste stellen in Deutschland die haeufigste Todesursache bei Patienten im Alter bis 45 Jahren dar . Ziele der praehospitalen Volumentherapie beim traumatisch-haemorrhagischen Schock sind die Steigerung des Intravasalvolumens und damit der kardialen Vorlast , um ueber eine Erhoehung des Herzzeitvolumens ein ausreichendes Sauerstoffangebot an die Gewebe wiederherzustellen . Das wichtigste therapeutische Element zur Praevention eines multiplen Organversagens nach Trauma und Schock ist jedoch die Normalisierung nicht allein der Makrohaemodynamik ( systemischer Blutdruck , Herzzeitvolumen ) , sondern die Beseitigung der Stoerung der mikrovaskulaeren Perfusion . Bei grossem Blutverlust ist dies durch konventionelle Volumentherapie mit Kristalloiden und kuenstlichen Kolloiden allein nicht erzielbar . Ein neues Konzept besteht in der intravenoesen Bolusinfusion eines kleines Volumens ( ca. 4 ml/kg Koerpergewicht ) einer stark hyperosmolaren ( 7,2-7,5%) Kochsalz-Kolloidloesung , und wird als Small-volume resuscitation " " bezeichnet . Die juengsten Ergebnisse einer Cohort-Analyse aus 8 praeklinischen Studien laesst erkennen , dass eine Steigerung der Ueberlebensrate um etwa 5% gegenueber einer Standardtherapie resultiert . In der Erprobung befinden sich ferner kuenstliche Sauerstofftraegerloesungen , welche erlauben sollen , ueber eine Erhoehung des O2-Gehalts im Blut die Sauerstoffverfuegbarkeit fuer die Gewebe zu steigern .
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[ "umlsterm" ]
BHRF1 is a Protein, Fas is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, BHRF1 is a Protein, Fas is a Protein, BHRF1 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, Bcl - xL is a Protein, Fas is a Protein, cytosolic phospholipase A2 is a Protein, caspase-3 is a Protein, CPP32 is a Protein, BHRF1 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, Fas is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein
773_task0
Sentence: The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.
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[ "Protein" ]
BHRF1 is a Protein, Fas is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, BHRF1 is a Protein, Fas is a Protein, BHRF1 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, Bcl - xL is a Protein, Fas is a Protein, cytosolic phospholipase A2 is a Protein, caspase-3 is a Protein, CPP32 is a Protein, BHRF1 is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein, Fas is a Protein, BHRF1 is a Protein, Bcl-2 is a Protein
773_task1
Sentence: The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus. Instructions: please typing these entity words according to sentence: BHRF1, Fas, BHRF1, Bcl-2, BHRF1, Fas, BHRF1, BHRF1, Bcl-2, BHRF1, Bcl-2, Bcl - xL, Fas, cytosolic phospholipase A2, caspase-3, CPP32, BHRF1, BHRF1, Bcl-2, Fas, BHRF1, Bcl-2 Options: Protein
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The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.
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[ "Protein" ]
BHRF1, Fas, BHRF1, Bcl-2, BHRF1, Fas, BHRF1, BHRF1, Bcl-2, BHRF1, Bcl-2, Bcl - xL, Fas, cytosolic phospholipase A2, caspase-3, CPP32, BHRF1, BHRF1, Bcl-2, Fas, BHRF1, Bcl-2
773_task2
Sentence: The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus. Instructions: please extract entity words from the input sentence
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The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein. Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis. In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells. The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL. Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors. A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production. Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells. Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.
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[ "Protein" ]
entecavir is a DRUG, BARACLUDE is a BRAND, entecavir is a DRUG, entecavir is a DRUG, lamivudine is a DRUG, adefovir dipivoxil is a DRUG, tenofovir disoproxil fumarate is a DRUG, BARACLUDE is a BRAND, BARACLUDE is a BRAND
Entecavir_ddi_task0
Sentence: Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: BRAND, DRUG
[ "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O" ]
Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs.
[ "Since", "entecavir", "is", "primarily", "eliminated", "by", "the", "kidneys", ",", "coadministration", "of", "BARACLUDE", "with", "drugs", "that", "reduce", "renal", "function", "or", "compete", "for", "active", "tubular", "secretion", "may", "increase", "serum", "concentrations", "of", "either", "entecavir", "or", "the", "coadministered", "drug", ".", "Coadministration", "of", "entecavir", "with", "lamivudine", ",", "adefovir", "dipivoxil", ",", "or", "tenofovir", "disoproxil", "fumarate", "did", "not", "result", "in", "significant", "drug", "interactions", ".", "The", "effects", "of", "coadministration", "of", "BARACLUDE", "with", "other", "drugs", "that", "are", "renally", "eliminated", "or", "are", "known", "to", "affect", "renal", "function", "have", "not", "been", "evaluated", ",", "and", "patients", "should", "be", "monitored", "closely", "for", "adverse", "events", "when", "BARACLUDE", "is", "coadministered", "with", "such", "drugs", "." ]
[ "DRUG", "BRAND" ]
entecavir is a DRUG, BARACLUDE is a BRAND, entecavir is a DRUG, entecavir is a DRUG, lamivudine is a DRUG, adefovir dipivoxil is a DRUG, tenofovir disoproxil fumarate is a DRUG, BARACLUDE is a BRAND, BARACLUDE is a BRAND
Entecavir_ddi_task1
Sentence: Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs. Instructions: please typing these entity words according to sentence: entecavir, BARACLUDE, entecavir, entecavir, lamivudine, adefovir dipivoxil, tenofovir disoproxil fumarate, BARACLUDE, BARACLUDE Options: BRAND, DRUG
[ "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O" ]
Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs.
[ "Since", "entecavir", "is", "primarily", "eliminated", "by", "the", "kidneys", ",", "coadministration", "of", "BARACLUDE", "with", "drugs", "that", "reduce", "renal", "function", "or", "compete", "for", "active", "tubular", "secretion", "may", "increase", "serum", "concentrations", "of", "either", "entecavir", "or", "the", "coadministered", "drug", ".", "Coadministration", "of", "entecavir", "with", "lamivudine", ",", "adefovir", "dipivoxil", ",", "or", "tenofovir", "disoproxil", "fumarate", "did", "not", "result", "in", "significant", "drug", "interactions", ".", "The", "effects", "of", "coadministration", "of", "BARACLUDE", "with", "other", "drugs", "that", "are", "renally", "eliminated", "or", "are", "known", "to", "affect", "renal", "function", "have", "not", "been", "evaluated", ",", "and", "patients", "should", "be", "monitored", "closely", "for", "adverse", "events", "when", "BARACLUDE", "is", "coadministered", "with", "such", "drugs", "." ]
[ "DRUG", "BRAND" ]
entecavir, BARACLUDE, entecavir, entecavir, lamivudine, adefovir dipivoxil, tenofovir disoproxil fumarate, BARACLUDE, BARACLUDE
Entecavir_ddi_task2
Sentence: Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs. Instructions: please extract entity words from the input sentence
[ "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "I-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O" ]
Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs.
[ "Since", "entecavir", "is", "primarily", "eliminated", "by", "the", "kidneys", ",", "coadministration", "of", "BARACLUDE", "with", "drugs", "that", "reduce", "renal", "function", "or", "compete", "for", "active", "tubular", "secretion", "may", "increase", "serum", "concentrations", "of", "either", "entecavir", "or", "the", "coadministered", "drug", ".", "Coadministration", "of", "entecavir", "with", "lamivudine", ",", "adefovir", "dipivoxil", ",", "or", "tenofovir", "disoproxil", "fumarate", "did", "not", "result", "in", "significant", "drug", "interactions", ".", "The", "effects", "of", "coadministration", "of", "BARACLUDE", "with", "other", "drugs", "that", "are", "renally", "eliminated", "or", "are", "known", "to", "affect", "renal", "function", "have", "not", "been", "evaluated", ",", "and", "patients", "should", "be", "monitored", "closely", "for", "adverse", "events", "when", "BARACLUDE", "is", "coadministered", "with", "such", "drugs", "." ]
[ "DRUG", "BRAND" ]
cáncer is a MORFOLOGIA_NEOPLASIA, carcinoma lobulillar infiltrante is a MORFOLOGIA_NEOPLASIA, pT2pN2M0 is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinoma is a MORFOLOGIA_NEOPLASIA, implantes de aspecto neoplásico is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinoma poco diferenciado is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel peritoneal is a MORFOLOGIA_NEOPLASIA, cáncer de mama estadio IV con metástasis is a MORFOLOGIA_NEOPLASIA
423_task0
Sentence: Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso.
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[ "MORFOLOGIA_NEOPLASIA" ]
cáncer is a MORFOLOGIA_NEOPLASIA, carcinoma lobulillar infiltrante is a MORFOLOGIA_NEOPLASIA, pT2pN2M0 is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinoma is a MORFOLOGIA_NEOPLASIA, implantes de aspecto neoplásico is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, carcinomatosis is a MORFOLOGIA_NEOPLASIA, carcinoma poco diferenciado is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel peritoneal is a MORFOLOGIA_NEOPLASIA, cáncer de mama estadio IV con metástasis is a MORFOLOGIA_NEOPLASIA
423_task1
Sentence: Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso. Instructions: please typing these entity words according to sentence: cáncer, carcinoma lobulillar infiltrante, pT2pN2M0, tumoral, carcinomatosis, carcinomatosis, carcinoma, implantes de aspecto neoplásico, malignidad, carcinomatosis, carcinoma poco diferenciado, enfermedad a nivel peritoneal, cáncer de mama estadio IV con metástasis Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso.
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[ "MORFOLOGIA_NEOPLASIA" ]
cáncer, carcinoma lobulillar infiltrante, pT2pN2M0, tumoral, carcinomatosis, carcinomatosis, carcinoma, implantes de aspecto neoplásico, malignidad, carcinomatosis, carcinoma poco diferenciado, enfermedad a nivel peritoneal, cáncer de mama estadio IV con metástasis
423_task2
Sentence: Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso. Instructions: please extract entity words from the input sentence
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Anamnesis Se trata de una paciente de 68 años con antecedentes personales de hipertensión arterial y dislipemia bien controladas con medicación. Destaca como único antecedente familiar oncológico, el diagnóstico de cáncer de mama de su hermana. La situación basal de la paciente es buena, siendo independiente para todas las actividades de la vida diaria. No realiza ningún tratamiento domiciliario. Centrándonos en la historia oncológica de la paciente, se diagnosticó un carcinoma lobulillar infiltrante de mama izquierda en 2014 que, tras cirugía mediante segmentectomía y linfadenectomía axilar, se cataloga por Anatomía Patológica como estadio pT2pN2M0 (IIIA) con estudio inmunohistoquímico (IHQ) con resultado de receptores de estrógenos y progesterona positivos y HER2 negativo. Tras el diagnóstico, recibió tratamiento con esquema fluorouracilo, epirrubicina y ciclofosfamida (FEC) durante cuatro ciclos con posterior administración de paclitaxel semanal y radioterapia complementaria sobre lecho tumoral. Tras finalizar el tratamiento adyuvante, la paciente comenzó tratamiento con letrozol (marzo de 2015), continuando con revisiones semestrales sin evidencia de recaída de la enfermedad. En noviembre de 2018, la paciente ingresa en su hospital de referencia por cuadro de dolor abdominal y clínica compatible con cuadros suboclusivos, siendo diagnosticada de ileítis inespecífica tras pruebas de imagen y Anatomía Patológica de biopsia colónica tomada por colonoscopia. Inició tratamiento con mesalazina y prednisona sin clara mejoría de la clínica, por lo que finalmente se retiró. En febrero de 2019, comienza con clínica de cuadro suboclusivo con dolor y distensión abdominal junto a estreñimiento pertinaz y vómitos incoercibles, ingresando de nuevo en su hospital de referencia. Exploración física Durante la exploración física destaca el buen estado general de la paciente con abdomen globuloso, con leves molestias a la palpación difusa, como único hallazgo de interés. Pruebas complementarias Se realiza una TC de abdomen donde se evidencia una extensa carcinomatosis peritoneal difusa con infiltración de asas intestinales con estenosis en íleon preterminal con dilatación retrógrada y una lesión quística anexial izquierda de 6 cm de diámetro máximo, destacando en analítica un CA 15.3 92,6 U/ml como único hallazgo. Tras su traslado a nuestro centro, se planteó un diagnóstico diferencial entre los posibles orígenes de la carcinomatosis, destacando principalmente carcinoma primario colorrectal, ovárico o mamario. Por ello, se realizó una colonoscopia donde se objetivaron implantes de aspecto neoplásico en sigma con fijación de las asas por dicho motivo, tomándose muestras para estudio. A la espera de resultados de Anatomía Patológica, se realizó ecografía vaginal para la visualización de la formación anexial izquierda, con evidencia de características de bajo riesgo de malignidad de larga evolución, siendo poco probable como origen de la carcinomatosis peritoneal. Diagnóstico Se diagnosticó en las biopsias colónicas de infiltración por carcinoma poco diferenciado con IHQ con mamoglobina positiva y receptores de estrógenos y progesterona, así como HER2 negativos, compatible con recaída de la enfermedad a nivel peritoneal, con trasformación histológica. Estamos, por tanto, ante una paciente con cáncer de mama estadio IV con metástasis a nivel peritoneal. Tratamiento Se realizó ileostomía en íleon preterminal para manejo sintomático y se inició quimioterapia con paclitaxel semanal. Evolución Actualmente, la paciente refiere buen estado general, pudiendo realizar actividades diarias sin incidencias y sin clínica asociada al proceso.
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[ "MORFOLOGIA_NEOPLASIA" ]
aortic valve is an umlsterm, disease is an umlsterm, complication is an umlsterm, adults is an umlsterm, aortic valve is an umlsterm, operation is an umlsterm, adults is an umlsterm, population is an umlsterm, Bicuspid is an umlsterm, aortic valves is an umlsterm, patients is an umlsterm, patients is an umlsterm, aortic stenosis is an umlsterm, age is an umlsterm, aortic valve is an umlsterm, age is an umlsterm, aortic regurgitation is an umlsterm, age is an umlsterm, aortic valve is an umlsterm, patients is an umlsterm, patients is an umlsterm, surgical is an umlsterm, aorta ascendens is an umlsterm, mitral valve is an umlsterm, aorto - coronary bypass is an umlsterm, patients is an umlsterm, mortality is an umlsterm, survival is an umlsterm, patients is an umlsterm, aortic valve is an umlsterm, disease is an umlsterm, period is an umlsterm, deaths is an umlsterm, cardia is an umlsterm
ZfuerKardiologie.70860676.eng.abstr_task0
Sentence: Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively .
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[ "umlsterm" ]
aortic valve is an umlsterm, disease is an umlsterm, complication is an umlsterm, adults is an umlsterm, aortic valve is an umlsterm, operation is an umlsterm, adults is an umlsterm, population is an umlsterm, Bicuspid is an umlsterm, aortic valves is an umlsterm, patients is an umlsterm, patients is an umlsterm, aortic stenosis is an umlsterm, age is an umlsterm, aortic valve is an umlsterm, age is an umlsterm, aortic regurgitation is an umlsterm, age is an umlsterm, aortic valve is an umlsterm, patients is an umlsterm, patients is an umlsterm, surgical is an umlsterm, aorta ascendens is an umlsterm, mitral valve is an umlsterm, aorto - coronary bypass is an umlsterm, patients is an umlsterm, mortality is an umlsterm, survival is an umlsterm, patients is an umlsterm, aortic valve is an umlsterm, disease is an umlsterm, period is an umlsterm, deaths is an umlsterm, cardia is an umlsterm
ZfuerKardiologie.70860676.eng.abstr_task1
Sentence: Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively . Instructions: please typing these entity words according to sentence: aortic valve, disease, complication, adults, aortic valve, operation, adults, population, Bicuspid, aortic valves, patients, patients, aortic stenosis, age, aortic valve, age, aortic regurgitation, age, aortic valve, patients, patients, surgical, aorta ascendens, mitral valve, aorto - coronary bypass, patients, mortality, survival, patients, aortic valve, disease, period, deaths, cardia Options: umlsterm
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Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively .
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[ "umlsterm" ]
aortic valve, disease, complication, adults, aortic valve, operation, adults, population, Bicuspid, aortic valves, patients, patients, aortic stenosis, age, aortic valve, age, aortic regurgitation, age, aortic valve, patients, patients, surgical, aorta ascendens, mitral valve, aorto - coronary bypass, patients, mortality, survival, patients, aortic valve, disease, period, deaths, cardia
ZfuerKardiologie.70860676.eng.abstr_task2
Sentence: Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively . Instructions: please extract entity words from the input sentence
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Severe aortic valve disease is a rare complication of coarctation in adults . Between 1961 and 1990 aortic valve replacement was performed after or combined with the operation of coarctation in 24 adults ( 4% of entire population operated for coarctation ) . Bicuspid aortic valves were present in 2/3 of patients . In 10 patients ( 710 with aortic stenosis ) coarctation was operated early ( mean age 24 years ) and aortic valve late ( mean age 40 years ) : in 14 ( 1014 with aortic regurgitation , mean age 40 years ) aortic valve and coarctation were operated simultaneously ( 8 patients ) or staged within 6 months ( 6 patients ) . Additional surgical interventions on the dilated aorta ascendens were performed in 8 , mitral valve replacement in 2 and aorto-coronary bypass in 1 patients . Early mortality was 224 ( 8% ) and was similar in simultaneously ( 18 ) and staged ( 114 ) operated cases : 10 year survival was lower than in an age-matched group of 72 patients with aortic valve disease of similar severity operated during the same period ( 70% vs 88% , p 0.01 ) : 67 late deaths were cardia ; 55 pts with preoperatively severely increased end-diastolic ( > 199 mlm2) and 44 with end-systolic ( > 90 mlm2) left ventricular volumes and 22 with ejection fraction 41 % died late postoperatively .
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[ "umlsterm" ]
Erregungsuebertragung is an umlsterm, Therapie is an umlsterm, Schmerzen is an umlsterm, Clonidin is an umlsterm, Schmerzen is an umlsterm
DerSchmerz.70110339.ger.abstr_task0
Sentence: 2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]
2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt .
[ "2-Adrenozeptor", "-", "Agonisten", "wirken", "ueber", "eine", "Hemmung", "der", "synaptischen", "Erregungsuebertragung", "antinozizeptiv", "und", "verstaerken", "die", "Wirkung", "von", "Opioiden", ".", "Zur", "Therapie", "chronischer", "Schmerzen", "wird", "Clonidin", "bei", "neuropathischen", ",", "neuralgischen", "Schmerzen", "und", "beim", "Deaffenzierungsschmerz", "eingesetzt", "." ]
[ "umlsterm" ]
Erregungsuebertragung is an umlsterm, Therapie is an umlsterm, Schmerzen is an umlsterm, Clonidin is an umlsterm, Schmerzen is an umlsterm
DerSchmerz.70110339.ger.abstr_task1
Sentence: 2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt . Instructions: please typing these entity words according to sentence: Erregungsuebertragung, Therapie, Schmerzen, Clonidin, Schmerzen Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]
2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt .
[ "2-Adrenozeptor", "-", "Agonisten", "wirken", "ueber", "eine", "Hemmung", "der", "synaptischen", "Erregungsuebertragung", "antinozizeptiv", "und", "verstaerken", "die", "Wirkung", "von", "Opioiden", ".", "Zur", "Therapie", "chronischer", "Schmerzen", "wird", "Clonidin", "bei", "neuropathischen", ",", "neuralgischen", "Schmerzen", "und", "beim", "Deaffenzierungsschmerz", "eingesetzt", "." ]
[ "umlsterm" ]
Erregungsuebertragung, Therapie, Schmerzen, Clonidin, Schmerzen
DerSchmerz.70110339.ger.abstr_task2
Sentence: 2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]
2-Adrenozeptor-Agonisten wirken ueber eine Hemmung der synaptischen Erregungsuebertragung antinozizeptiv und verstaerken die Wirkung von Opioiden . Zur Therapie chronischer Schmerzen wird Clonidin bei neuropathischen , neuralgischen Schmerzen und beim Deaffenzierungsschmerz eingesetzt .
[ "2-Adrenozeptor", "-", "Agonisten", "wirken", "ueber", "eine", "Hemmung", "der", "synaptischen", "Erregungsuebertragung", "antinozizeptiv", "und", "verstaerken", "die", "Wirkung", "von", "Opioiden", ".", "Zur", "Therapie", "chronischer", "Schmerzen", "wird", "Clonidin", "bei", "neuropathischen", ",", "neuralgischen", "Schmerzen", "und", "beim", "Deaffenzierungsschmerz", "eingesetzt", "." ]
[ "umlsterm" ]
E2F complex is a protein_complex, human primary haemopoietic cells is a cell_type, AML blasts is a cell_type, E2F-4 is a protein_molecule, DP-1 is a protein_molecule, p130 is a protein_molecule
66541_task0
Sentence: The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_molecule, protein_complex
[ "O", "O", "B-protein_complex", "I-protein_complex", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "B-cell_type", "I-cell_type", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O" ]
The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.
[ "The", "predominant", "E2F", "complex", "in", "human", "primary", "haemopoietic", "cells", "and", "in", "AML", "blasts", "contains", "E2F-4", ",", "DP-1", "and", "p130", "." ]
[ "cell_type", "other_name", "DNA_family_or_group", "protein_complex", "protein_family_or_group", "multi_cell", "protein_molecule" ]
E2F complex is a protein_complex, human primary haemopoietic cells is a cell_type, AML blasts is a cell_type, E2F-4 is a protein_molecule, DP-1 is a protein_molecule, p130 is a protein_molecule
66541_task1
Sentence: The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. Instructions: please typing these entity words according to sentence: E2F complex, human primary haemopoietic cells, AML blasts, E2F-4, DP-1, p130 Options: cell_type, protein_molecule, protein_complex
[ "O", "O", "B-protein_complex", "I-protein_complex", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "B-cell_type", "I-cell_type", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O" ]
The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.
[ "The", "predominant", "E2F", "complex", "in", "human", "primary", "haemopoietic", "cells", "and", "in", "AML", "blasts", "contains", "E2F-4", ",", "DP-1", "and", "p130", "." ]
[ "cell_type", "other_name", "DNA_family_or_group", "protein_complex", "protein_family_or_group", "multi_cell", "protein_molecule" ]
E2F complex, human primary haemopoietic cells, AML blasts, E2F-4, DP-1, p130
66541_task2
Sentence: The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-protein_complex", "I-protein_complex", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "B-cell_type", "I-cell_type", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O" ]
The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.
[ "The", "predominant", "E2F", "complex", "in", "human", "primary", "haemopoietic", "cells", "and", "in", "AML", "blasts", "contains", "E2F-4", ",", "DP-1", "and", "p130", "." ]
[ "cell_type", "other_name", "DNA_family_or_group", "protein_complex", "protein_family_or_group", "multi_cell", "protein_molecule" ]
older is an umlsterm, people is an umlsterm, continuing education is an umlsterm, communication is an umlsterm, co - operation is an umlsterm, Internet is an umlsterm, Institutes is an umlsterm, continuing education is an umlsterm, older is an umlsterm, people is an umlsterm, training is an umlsterm, media is an umlsterm, media is an umlsterm, competence is an umlsterm, educational is an umlsterm, people is an umlsterm, communication is an umlsterm, technologies is an umlsterm, Learning is an umlsterm, Life is an umlsterm, Learning is an umlsterm, Research is an umlsterm, culture is an umlsterm, universities is an umlsterm, health is an umlsterm, educational is an umlsterm
ZfuerGerontologie+Geriatrie.00330186.eng.abstr_task0
Sentence: More and more older people interested in continuing education recognise the many possibilties for information , communication and co-operation which Internet offers to them . Institutes of continuing education and other institutions serving older people are required to provide training for this target group in order to make access to the world of the digital media easier , to support them in acquiring media competence and to design interesting virtual educational programmes and courses . In this article , the possibilities of showing people over 50 the way to the new communication technologies will be described in view of the experiences gained during the information campaign " Senior-Info-Mobil " . It will also be demonstrated based on the examples of the European network " Learning in Later Life " and other projects such as " Learning through Research " that virtual working groups and networks of elders can become a driving force of a new " learning culture " , involving also those who do not live near universities or who for health and other personal reasons cannot participate in educational programmes offered in the area . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
More and more older people interested in continuing education recognise the many possibilties for information , communication and co-operation which Internet offers to them . Institutes of continuing education and other institutions serving older people are required to provide training for this target group in order to make access to the world of the digital media easier , to support them in acquiring media competence and to design interesting virtual educational programmes and courses . In this article , the possibilities of showing people over 50 the way to the new communication technologies will be described in view of the experiences gained during the information campaign " Senior-Info-Mobil " . It will also be demonstrated based on the examples of the European network " Learning in Later Life " and other projects such as " Learning through Research " that virtual working groups and networks of elders can become a driving force of a new " learning culture " , involving also those who do not live near universities or who for health and other personal reasons cannot participate in educational programmes offered in the area .
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[ "umlsterm" ]