bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
clozapine, 5-hydroxytryptamine1C, 5-hydroxytryptamine2	1403790_task2	Sentence: The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O" ]	The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors.	[ "The", "discriminative", "stimulus", "effects", "of", "clozapine", "in", "pigeons", ":", "involvement", "of", "5-hydroxytryptamine1C", "and", "5-hydroxytryptamine2", "receptors", "." ]	[ "CHEMICAL", "GENE-N" ]
chemokine ( C - C motif ) ligand 2 is a GENE-Y, monocyte chemotactic protein-1 is a GENE-Y, cisplatin is a CHEMICAL	23291264_task0	Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]	Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.	[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
chemokine ( C - C motif ) ligand 2 is a GENE-Y, monocyte chemotactic protein-1 is a GENE-Y, cisplatin is a CHEMICAL	23291264_task1	Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please typing these entity words according to sentence: chemokine ( C - C motif ) ligand 2, monocyte chemotactic protein-1, cisplatin Options: GENE-Y, CHEMICAL	[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]	Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.	[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
chemokine ( C - C motif ) ligand 2, monocyte chemotactic protein-1, cisplatin	23291264_task2	Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please extract entity words from the input sentence	[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]	Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.	[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
actin is a Gene/protein/RNA, actin is a Individual_protein, actin depolymerizing factor is a Individual_protein, ADF is a Individual_protein, gelsolin is a Individual_protein, profilin is a Individual_protein, thymosin beta4 is a Individual_protein, Tbeta4 is a Individual_protein	196_task0	Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]	Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).	[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
actin is a Gene/protein/RNA, actin is a Individual_protein, actin depolymerizing factor is a Individual_protein, ADF is a Individual_protein, gelsolin is a Individual_protein, profilin is a Individual_protein, thymosin beta4 is a Individual_protein, Tbeta4 is a Individual_protein	196_task1	Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please typing these entity words according to sentence: actin, actin, actin depolymerizing factor, ADF, gelsolin, profilin, thymosin beta4, Tbeta4 Options: Gene/protein/RNA, Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]	Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).	[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
actin, actin, actin depolymerizing factor, ADF, gelsolin, profilin, thymosin beta4, Tbeta4	196_task2	Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]	Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).	[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]	[ "Individual_protein", "Gene/protein/RNA" ]
RAD54 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA	682_task0	Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA	[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.	[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]	[ "Gene/protein/RNA" ]
RAD54 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA	682_task1	Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please typing these entity words according to sentence: RAD54, RAD51 Options: Gene/protein/RNA	[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.	[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]	[ "Gene/protein/RNA" ]
RAD54, RAD51	682_task2	Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please extract entity words from the input sentence	[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.	[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]	[ "Gene/protein/RNA" ]
complication is an umlsterm, time is an umlsterm, catheter is an umlsterm, patient is an umlsterm, complication is an umlsterm, dislocation is an umlsterm, catheter is an umlsterm, Hydromediastinum is an umlsterm, hydrothorax is an umlsterm, diagnosis is an umlsterm, catheter is an umlsterm, cause is an umlsterm, complication is an umlsterm, symptoms is an umlsterm, mediastinitis is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, patient is an umlsterm, treatment is an umlsterm, malformation is an umlsterm	DerAnaesthesist.90480900.eng.abstr_task0	Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .	[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]	[ "umlsterm" ]
complication is an umlsterm, time is an umlsterm, catheter is an umlsterm, patient is an umlsterm, complication is an umlsterm, dislocation is an umlsterm, catheter is an umlsterm, Hydromediastinum is an umlsterm, hydrothorax is an umlsterm, diagnosis is an umlsterm, catheter is an umlsterm, cause is an umlsterm, complication is an umlsterm, symptoms is an umlsterm, mediastinitis is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, patient is an umlsterm, treatment is an umlsterm, malformation is an umlsterm	DerAnaesthesist.90480900.eng.abstr_task1	Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please typing these entity words according to sentence: complication, time, catheter, patient, complication, dislocation, catheter, Hydromediastinum, hydrothorax, diagnosis, catheter, cause, complication, symptoms, mediastinitis, antibiotic, therapy, patient, treatment, malformation Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .	[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]	[ "umlsterm" ]
complication, time, catheter, patient, complication, dislocation, catheter, Hydromediastinum, hydrothorax, diagnosis, catheter, cause, complication, symptoms, mediastinitis, antibiotic, therapy, patient, treatment, malformation	DerAnaesthesist.90480900.eng.abstr_task2	Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .	[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]	[ "umlsterm" ]
Objective is an umlsterm, joint is an umlsterm	ZfuerRheumatologie.0059ii90.eng.abstr_task0	Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .	[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]	[ "umlsterm" ]
Objective is an umlsterm, joint is an umlsterm	ZfuerRheumatologie.0059ii90.eng.abstr_task1	Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please typing these entity words according to sentence: Objective, joint Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .	[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]	[ "umlsterm" ]
Objective, joint	ZfuerRheumatologie.0059ii90.eng.abstr_task2	Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .	[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]	[ "umlsterm" ]
wachsende is an umlsterm, alter Menschen is an umlsterm, Element is an umlsterm, Euthanasiedebatte is an umlsterm	ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task0	Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .	[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]	[ "umlsterm" ]
wachsende is an umlsterm, alter Menschen is an umlsterm, Element is an umlsterm, Euthanasiedebatte is an umlsterm	ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task1	Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please typing these entity words according to sentence: wachsende, alter Menschen, Element, Euthanasiedebatte Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .	[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]	[ "umlsterm" ]
wachsende, alter Menschen, Element, Euthanasiedebatte	ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task2	Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .	[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]	[ "umlsterm" ]
4-phenylpiperidines is a CHEMICAL, 4-phenylpiperazines is a CHEMICAL	23353756_task0	Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.	[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]	[ "CHEMICAL", "GENE-Y" ]
4-phenylpiperidines is a CHEMICAL, 4-phenylpiperazines is a CHEMICAL	23353756_task1	Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please typing these entity words according to sentence: 4-phenylpiperidines, 4-phenylpiperazines Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.	[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]	[ "CHEMICAL", "GENE-Y" ]
4-phenylpiperidines, 4-phenylpiperazines	23353756_task2	Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.	[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]	[ "CHEMICAL", "GENE-Y" ]
other cancers is a Condition, at the same time is a Temporal, other cancers is a Condition, except is a Negation, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus is a Scope, active is a Temporal, infections is a Condition, not is a Negation, suitable for chemotherapy is a Qualifier, severe is a Qualifier, non - cancerous diseases is a Condition, neoadjuvant hormone therapy is a Procedure, bilateral breast cancers is a Condition, DCIS is a Condition, metastatic breast cancers is a Condition, anti - cancer therapies is a Procedure, attending other clinical trials is a Observation, pregnant is a Condition, lactational is a Condition, refuse to practice is a Negation, contraception is a Procedure, during the whole trial is a Temporal, allergic history or contraindication is a Scope, tamoxifen is a Drug	NCT02062489_exc_task0	Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Observation, Procedure, Negation, Scope, Drug	[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]	The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.	[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]	[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]
other cancers is a Condition, at the same time is a Temporal, other cancers is a Condition, except is a Negation, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus is a Scope, active is a Temporal, infections is a Condition, not is a Negation, suitable for chemotherapy is a Qualifier, severe is a Qualifier, non - cancerous diseases is a Condition, neoadjuvant hormone therapy is a Procedure, bilateral breast cancers is a Condition, DCIS is a Condition, metastatic breast cancers is a Condition, anti - cancer therapies is a Procedure, attending other clinical trials is a Observation, pregnant is a Condition, lactational is a Condition, refuse to practice is a Negation, contraception is a Procedure, during the whole trial is a Temporal, allergic history or contraindication is a Scope, tamoxifen is a Drug	NCT02062489_exc_task1	Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please typing these entity words according to sentence: other cancers, at the same time, other cancers, except, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus, active, infections, not, suitable for chemotherapy, severe, non - cancerous diseases, neoadjuvant hormone therapy, bilateral breast cancers, DCIS, metastatic breast cancers, anti - cancer therapies, attending other clinical trials, pregnant, lactational, refuse to practice, contraception, during the whole trial, allergic history or contraindication, tamoxifen Options: Temporal, Condition, Qualifier, Observation, Procedure, Negation, Scope, Drug	[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]	The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.	[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]	[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]
other cancers, at the same time, other cancers, except, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus, active, infections, not, suitable for chemotherapy, severe, non - cancerous diseases, neoadjuvant hormone therapy, bilateral breast cancers, DCIS, metastatic breast cancers, anti - cancer therapies, attending other clinical trials, pregnant, lactational, refuse to practice, contraception, during the whole trial, allergic history or contraindication, tamoxifen	NCT02062489_exc_task2	Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]	The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.	[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]	[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]
Abstract is an umlsterm, tissue culture is an umlsterm, method is an umlsterm, technique is an umlsterm, cell is an umlsterm, metabolic disorders is an umlsterm, Standard is an umlsterm, methods is an umlsterm, in vitro is an umlsterm, culture is an umlsterm, tumor is an umlsterm, cultures is an umlsterm, organ cultures is an umlsterm, ation is an umlsterm, tissue is an umlsterm, tissue culture is an umlsterm, cell culture is an umlsterm, genetic material is an umlsterm, cells is an umlsterm	DerPathologe.40150141.eng.abstr_task0	Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .	[ "Abstract", ".", "This", "article", "describes", "how", "tissue", "culture", "has", "developed", "from", "an", "observing", "method", "to", "a", "powerful", "analytical", "technique", "for", "oncology", "and", "for", "pathological", "cell", "changes", "such", "as", "metabolic", "disorders", "and", "degenerative", "diseas", "es", ".", "Standard", "terms", "are", "defined", "and", "basic", "methods", "are", "explained", ".", "Different", "models", "of", "in", "vitro", "culture", "-", "monolayer", ",", "three", "-", "dimensional", "tumor", "cultures", ",", "and", "organ", "cultures", "-", "are", "critically", "reviewed", "in", "respect", "of", "their", "significance", "for", "the", "interpret", "ation", "of", "in", "vivo", "tissue", ".", "Two", "important", "recent", "extensions", "of", "tissue", "culture", ",", "serum", "-", "free", "cell", "culture", "and", "the", "introduction", "of", "genetic", "material", "into", "cells", ",", "are", "described", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, tissue culture is an umlsterm, method is an umlsterm, technique is an umlsterm, cell is an umlsterm, metabolic disorders is an umlsterm, Standard is an umlsterm, methods is an umlsterm, in vitro is an umlsterm, culture is an umlsterm, tumor is an umlsterm, cultures is an umlsterm, organ cultures is an umlsterm, ation is an umlsterm, tissue is an umlsterm, tissue culture is an umlsterm, cell culture is an umlsterm, genetic material is an umlsterm, cells is an umlsterm	DerPathologe.40150141.eng.abstr_task1	Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please typing these entity words according to sentence: Abstract, tissue culture, method, technique, cell, metabolic disorders, Standard, methods, in vitro, culture, tumor, cultures, organ cultures, ation, tissue, tissue culture, cell culture, genetic material, cells Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .	[ "Abstract", ".", "This", "article", "describes", "how", "tissue", "culture", "has", "developed", "from", "an", "observing", "method", "to", "a", "powerful", "analytical", "technique", "for", "oncology", "and", "for", "pathological", "cell", "changes", "such", "as", "metabolic", "disorders", "and", "degenerative", "diseas", "es", ".", "Standard", "terms", "are", "defined", "and", "basic", "methods", "are", "explained", ".", "Different", "models", "of", "in", "vitro", "culture", "-", "monolayer", ",", "three", "-", "dimensional", "tumor", "cultures", ",", "and", "organ", "cultures", "-", "are", "critically", "reviewed", "in", "respect", "of", "their", "significance", "for", "the", "interpret", "ation", "of", "in", "vivo", "tissue", ".", "Two", "important", "recent", "extensions", "of", "tissue", "culture", ",", "serum", "-", "free", "cell", "culture", "and", "the", "introduction", "of", "genetic", "material", "into", "cells", ",", "are", "described", "." ]	[ "umlsterm" ]
Abstract, tissue culture, method, technique, cell, metabolic disorders, Standard, methods, in vitro, culture, tumor, cultures, organ cultures, ation, tissue, tissue culture, cell culture, genetic material, cells	DerPathologe.40150141.eng.abstr_task2	Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .	[ "Abstract", ".", "This", "article", "describes", "how", "tissue", "culture", "has", "developed", "from", "an", "observing", "method", "to", "a", "powerful", "analytical", "technique", "for", "oncology", "and", "for", "pathological", "cell", "changes", "such", "as", "metabolic", "disorders", "and", "degenerative", "diseas", "es", ".", "Standard", "terms", "are", "defined", "and", "basic", "methods", "are", "explained", ".", "Different", "models", "of", "in", "vitro", "culture", "-", "monolayer", ",", "three", "-", "dimensional", "tumor", "cultures", ",", "and", "organ", "cultures", "-", "are", "critically", "reviewed", "in", "respect", "of", "their", "significance", "for", "the", "interpret", "ation", "of", "in", "vivo", "tissue", ".", "Two", "important", "recent", "extensions", "of", "tissue", "culture", ",", "serum", "-", "free", "cell", "culture", "and", "the", "introduction", "of", "genetic", "material", "into", "cells", ",", "are", "described", "." ]	[ "umlsterm" ]
Blutfluss is an umlsterm, Vasodilatation is an umlsterm, Methode is an umlsterm, Diagnostik is an umlsterm, Techniken is an umlsterm, Thermodilution is an umlsterm, Sauerstoffsaettigung is an umlsterm, Argon - Fremdgas - Methode is an umlsterm, Analyse is an umlsterm, Mikrozirkulation is an umlsterm, Therapie is an umlsterm, Methoden is an umlsterm, Densitometrie is an umlsterm, Druckdraht is an umlsterm, Methode is an umlsterm, Koronargefaess is an umlsterm, Koronarstenose is an umlsterm, Beurteilung is an umlsterm, Methode is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Myokardfunktion is an umlsterm, Patienten is an umlsterm	ZfuerKardiologie.8087s074.ger.abstr_task0	Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .	[ "Die", "Bestimmung", "der", "koronaren", "Flussreserve", ",", "dem", "Verhaeltnis", "aus", "koronarem", "Blutfluss", "unter", "maximaler", "Vasodilatation", "und", "in", "Ruhe", ",", "ist", "ergaenzend", "zur", "rein", "bildmorphologischen", ",", "angiographischen", "Darstellung", "eine", "funktionelle", "Methode", "zur", "Diagnostik", "der", "koronaren", "Strombahn", ".", "Die", "derzeit", "zur", "Verfuegung", "stehenden", "Untersuchungsmethoden", "und", "deren", "verschiedenen", "Techniken", "werden", "besonders", "unter", "dem", "Aspekt", "der", "klinischen", "Einsatzmoeglichkeiten", "und", "der", "spezifischen", "Relevanz", "bei", "koronarer", "Makro-", "und", "Mikroangiopathie", "dargestellt", ".", "1", ".", "Koronarsinustechniken", ",", "wie", "die", "Thermodilution", "oder", "die", "Messung", "der", "Sauerstoffsaettigung", ",", "sind", "aufgrund", "einer", "grossen", "Streubreite", "nur", "als", "semiquantitativ", "anzusehen", ".", "Die", "Argon", "-", "Fremdgas", "-", "Methode", "kann", "durch", "die", "quantitative", "Analyse", "des", "absoluten", "Koronarflusses", "Stoerungen", "der", "koronaren", "Mikrozirkulation", "funktionell", "untersuchen", "und", "laesst", "Moeglichkeiten", "zu", "Verlaufskontrollen", "unter", "entsprechender", "Therapie", ".", "2", ".", "Von", "den", "angiographischen", "Methoden", "ist", "die", "TIMI", "-", "Frame", "-", "Count", "-", "Methode", "fuer", "die", "Bestimmung", "der", "koronaren", "Reserve", "ungeeignet", "und", "die", "Densitometrie", "kann", "nur", "an", "einem", "hochselektionierten", "Kollektiv", "eingeschraenkt", "Aussagen", "zur", "Funktion", "der", "koronaren", "Strombahn", "ermoeglichen", ".", "3", ".", "Als", "intrakoronare", "Untersuchungsmethode", "ist", "neben", "dem", "technisch", "noch", "nicht", "ausgereiften", "Druckdraht", "besonders", "der", "intrakoronare", "Doppler", "eine", "Methode", "zur", "Messung", "der", ",", "jedoch", "regional", "auf", "das", "jeweilige", "Koronargefaess", "begrenzten", ",", "koronaren", "Flussreserve", ".", "Sie", "eignet", "sich", "vor", "allem", "zur", "Bestimmung", "der", "funktionellen", "Relevanz", "einer", "grenzwertigen", "Koronarstenose", "und", "zur", "Beurteilung", "des", "Erfolges", "nach", "einer", "koronaren", "Intervention", ".", "Es", "gibt", "keine", "einheitliche", "Methode", "zur", "Bestimmung", "der", "Koronarreserve", ",", "sondern", "jede", "dieser", "Methoden", "sollte", "mit", "ihren", "spezifischen", "Vor-", "und", "Nachteilen", "bei", "den", "entsprechenden", "Fragestellungen", "fuer", "den", "jeweiligen", "Patienten", "angewendet", "werden", ",", "um", "eine", "funktionelle", "Diagnostik", "zu", "ermoeglichen", ",", "die", "jedoch", "nicht", "isoliert", ",", "sondern", "immer", "in", "Bezug", "zur", "Myokardfunktion", "und", "klinischen", "Symptomatik", "des", "Patienten", "gesetzt", "werden", "muss", "." ]	[ "umlsterm" ]
Blutfluss is an umlsterm, Vasodilatation is an umlsterm, Methode is an umlsterm, Diagnostik is an umlsterm, Techniken is an umlsterm, Thermodilution is an umlsterm, Sauerstoffsaettigung is an umlsterm, Argon - Fremdgas - Methode is an umlsterm, Analyse is an umlsterm, Mikrozirkulation is an umlsterm, Therapie is an umlsterm, Methoden is an umlsterm, Densitometrie is an umlsterm, Druckdraht is an umlsterm, Methode is an umlsterm, Koronargefaess is an umlsterm, Koronarstenose is an umlsterm, Beurteilung is an umlsterm, Methode is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Myokardfunktion is an umlsterm, Patienten is an umlsterm	ZfuerKardiologie.8087s074.ger.abstr_task1	Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . 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Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .	[ "Die", "Bestimmung", "der", "koronaren", "Flussreserve", ",", "dem", "Verhaeltnis", "aus", "koronarem", "Blutfluss", "unter", "maximaler", "Vasodilatation", "und", "in", "Ruhe", ",", "ist", "ergaenzend", "zur", "rein", "bildmorphologischen", ",", "angiographischen", "Darstellung", "eine", "funktionelle", "Methode", "zur", "Diagnostik", "der", "koronaren", "Strombahn", ".", "Die", "derzeit", "zur", "Verfuegung", "stehenden", "Untersuchungsmethoden", "und", "deren", "verschiedenen", "Techniken", "werden", "besonders", "unter", "dem", "Aspekt", "der", "klinischen", "Einsatzmoeglichkeiten", "und", "der", "spezifischen", "Relevanz", "bei", "koronarer", "Makro-", "und", "Mikroangiopathie", "dargestellt", ".", "1", ".", "Koronarsinustechniken", ",", "wie", "die", "Thermodilution", "oder", "die", "Messung", "der", "Sauerstoffsaettigung", ",", "sind", "aufgrund", "einer", "grossen", "Streubreite", "nur", "als", "semiquantitativ", "anzusehen", ".", "Die", "Argon", "-", "Fremdgas", "-", "Methode", "kann", "durch", "die", "quantitative", "Analyse", "des", "absoluten", "Koronarflusses", "Stoerungen", "der", "koronaren", "Mikrozirkulation", "funktionell", "untersuchen", "und", "laesst", "Moeglichkeiten", "zu", "Verlaufskontrollen", "unter", "entsprechender", "Therapie", ".", "2", ".", "Von", "den", "angiographischen", "Methoden", "ist", "die", "TIMI", "-", "Frame", "-", "Count", "-", "Methode", "fuer", "die", "Bestimmung", "der", "koronaren", "Reserve", "ungeeignet", "und", "die", "Densitometrie", "kann", "nur", "an", "einem", "hochselektionierten", "Kollektiv", "eingeschraenkt", "Aussagen", "zur", "Funktion", "der", "koronaren", "Strombahn", "ermoeglichen", ".", "3", ".", "Als", "intrakoronare", "Untersuchungsmethode", "ist", "neben", "dem", "technisch", "noch", "nicht", "ausgereiften", "Druckdraht", "besonders", "der", "intrakoronare", "Doppler", "eine", "Methode", "zur", "Messung", "der", ",", "jedoch", "regional", "auf", "das", "jeweilige", "Koronargefaess", "begrenzten", ",", "koronaren", "Flussreserve", ".", "Sie", "eignet", "sich", "vor", "allem", "zur", "Bestimmung", "der", "funktionellen", "Relevanz", "einer", "grenzwertigen", "Koronarstenose", "und", "zur", "Beurteilung", "des", "Erfolges", "nach", "einer", "koronaren", "Intervention", ".", "Es", "gibt", "keine", "einheitliche", "Methode", "zur", "Bestimmung", "der", "Koronarreserve", ",", "sondern", "jede", "dieser", "Methoden", "sollte", "mit", "ihren", "spezifischen", "Vor-", "und", "Nachteilen", "bei", "den", "entsprechenden", "Fragestellungen", "fuer", "den", "jeweiligen", "Patienten", "angewendet", "werden", ",", "um", "eine", "funktionelle", "Diagnostik", "zu", "ermoeglichen", ",", "die", "jedoch", "nicht", "isoliert", ",", "sondern", "immer", "in", "Bezug", "zur", "Myokardfunktion", "und", "klinischen", "Symptomatik", "des", "Patienten", "gesetzt", "werden", "muss", "." ]	[ "umlsterm" ]
Blutfluss, Vasodilatation, Methode, Diagnostik, Techniken, Thermodilution, Sauerstoffsaettigung, Argon - Fremdgas - Methode, Analyse, Mikrozirkulation, Therapie, Methoden, Densitometrie, Druckdraht, Methode, Koronargefaess, Koronarstenose, Beurteilung, Methode, Methoden, Patienten, Diagnostik, Myokardfunktion, Patienten	ZfuerKardiologie.8087s074.ger.abstr_task2	Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .	[ "Die", "Bestimmung", "der", "koronaren", "Flussreserve", ",", "dem", "Verhaeltnis", "aus", "koronarem", "Blutfluss", "unter", "maximaler", "Vasodilatation", "und", "in", "Ruhe", ",", "ist", "ergaenzend", "zur", "rein", "bildmorphologischen", ",", "angiographischen", "Darstellung", "eine", "funktionelle", "Methode", "zur", "Diagnostik", "der", "koronaren", "Strombahn", ".", "Die", "derzeit", "zur", "Verfuegung", "stehenden", "Untersuchungsmethoden", "und", "deren", "verschiedenen", "Techniken", "werden", "besonders", "unter", "dem", "Aspekt", "der", "klinischen", "Einsatzmoeglichkeiten", "und", "der", "spezifischen", "Relevanz", "bei", "koronarer", "Makro-", "und", "Mikroangiopathie", "dargestellt", ".", "1", ".", "Koronarsinustechniken", ",", "wie", "die", "Thermodilution", "oder", "die", "Messung", "der", "Sauerstoffsaettigung", ",", "sind", "aufgrund", "einer", "grossen", "Streubreite", "nur", "als", "semiquantitativ", "anzusehen", ".", "Die", "Argon", "-", "Fremdgas", "-", "Methode", "kann", "durch", "die", "quantitative", "Analyse", "des", "absoluten", "Koronarflusses", "Stoerungen", "der", "koronaren", "Mikrozirkulation", "funktionell", "untersuchen", "und", "laesst", "Moeglichkeiten", "zu", "Verlaufskontrollen", "unter", "entsprechender", "Therapie", ".", "2", ".", "Von", "den", "angiographischen", "Methoden", "ist", "die", "TIMI", "-", "Frame", "-", "Count", "-", "Methode", "fuer", "die", "Bestimmung", "der", "koronaren", "Reserve", "ungeeignet", "und", "die", "Densitometrie", "kann", "nur", "an", "einem", "hochselektionierten", "Kollektiv", "eingeschraenkt", "Aussagen", "zur", "Funktion", "der", "koronaren", "Strombahn", "ermoeglichen", ".", "3", ".", "Als", "intrakoronare", "Untersuchungsmethode", "ist", "neben", "dem", "technisch", "noch", "nicht", "ausgereiften", "Druckdraht", "besonders", "der", "intrakoronare", "Doppler", "eine", "Methode", "zur", "Messung", "der", ",", "jedoch", "regional", "auf", "das", "jeweilige", "Koronargefaess", "begrenzten", ",", "koronaren", "Flussreserve", ".", "Sie", "eignet", "sich", "vor", "allem", "zur", "Bestimmung", "der", "funktionellen", "Relevanz", "einer", "grenzwertigen", "Koronarstenose", "und", "zur", "Beurteilung", "des", "Erfolges", "nach", "einer", "koronaren", "Intervention", ".", "Es", "gibt", "keine", "einheitliche", "Methode", "zur", "Bestimmung", "der", "Koronarreserve", ",", "sondern", "jede", "dieser", "Methoden", "sollte", "mit", "ihren", "spezifischen", "Vor-", "und", "Nachteilen", "bei", "den", "entsprechenden", "Fragestellungen", "fuer", "den", "jeweiligen", "Patienten", "angewendet", "werden", ",", "um", "eine", "funktionelle", "Diagnostik", "zu", "ermoeglichen", ",", "die", "jedoch", "nicht", "isoliert", ",", "sondern", "immer", "in", "Bezug", "zur", "Myokardfunktion", "und", "klinischen", "Symptomatik", "des", "Patienten", "gesetzt", "werden", "muss", "." ]	[ "umlsterm" ]
ATP is a chemical, PKM is a protein, lysine is an amino-acid, tryptophan is an amino-acid, K221W is a mutation, Raf-1 is a protein	1.0alpha7.train.791_task0	Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: amino-acid, chemical, mutation, protein	[ "O", "O", "O", "B-chemical", "O", "O", "O", "O", "B-protein", "O", "O", "B-amino-acid", "O", "O", "O", "O", "B-amino-acid", "O", "B-mutation", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).	[ "Within", "the", " ", "ATP", "binding", "site", "of", " ", "PKM", ",", " ", "lysine", "221", "was", "changed", "to", "tryptophan", "(", "K221W", ")", "corresponding", "to", "a", "mutation", "in", " ", "Raf-1", "that", "abolished", "its", "kinase", "activity", "(", "41", ")", "." ]	[ "amino-acid", "mutation", "protein", "chemical" ]
ATP is a chemical, PKM is a protein, lysine is an amino-acid, tryptophan is an amino-acid, K221W is a mutation, Raf-1 is a protein	1.0alpha7.train.791_task1	Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please typing these entity words according to sentence: ATP, PKM, lysine, tryptophan, K221W, Raf-1 Options: amino-acid, chemical, mutation, protein	[ "O", "O", "O", "B-chemical", "O", "O", "O", "O", "B-protein", "O", "O", "B-amino-acid", "O", "O", "O", "O", "B-amino-acid", "O", "B-mutation", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).	[ "Within", "the", " ", "ATP", "binding", "site", "of", " ", "PKM", ",", " ", "lysine", "221", "was", "changed", "to", "tryptophan", "(", "K221W", ")", "corresponding", "to", "a", "mutation", "in", " ", "Raf-1", "that", "abolished", "its", "kinase", "activity", "(", "41", ")", "." ]	[ "amino-acid", "mutation", "protein", "chemical" ]
ATP, PKM, lysine, tryptophan, K221W, Raf-1	1.0alpha7.train.791_task2	Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-chemical", "O", "O", "O", "O", "B-protein", "O", "O", "B-amino-acid", "O", "O", "O", "O", "B-amino-acid", "O", "B-mutation", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).	[ "Within", "the", " ", "ATP", "binding", "site", "of", " ", "PKM", ",", " ", "lysine", "221", "was", "changed", "to", "tryptophan", "(", "K221W", ")", "corresponding", "to", "a", "mutation", "in", " ", "Raf-1", "that", "abolished", "its", "kinase", "activity", "(", "41", ")", "." ]	[ "amino-acid", "mutation", "protein", "chemical" ]
Verletzungen is an umlsterm, unteren Hohlvene is an umlsterm, Komplikation is an umlsterm, Fallbericht is an umlsterm, Dissektion is an umlsterm, Beckenvenenthrombose is an umlsterm, Komplikation is an umlsterm	DerRadiologe.80380434.ger.abstr_task0	Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .	[ "Verletzungen", "der", "unteren", "Hohlvene", "sind", "eine", "seltene", "Komplikation", "gefaesschirurgischer", "Eingriffe", ".", "In", "einem", "Fallbericht", "werden", "die", "Dissektion", "und", "Perforation", "der", "V.", "cava", "inferior", "durch", "ein", "Fogarty", "-", "Ballonmanoever", "bei", "postoperativer", "Beckenvenenthrombose", "und", "der", "computertomo-", "sowie", "phlebographische", "Nachweis", "dieser", "Komplikation", "beschrieben", "." ]	[ "umlsterm" ]
Verletzungen is an umlsterm, unteren Hohlvene is an umlsterm, Komplikation is an umlsterm, Fallbericht is an umlsterm, Dissektion is an umlsterm, Beckenvenenthrombose is an umlsterm, Komplikation is an umlsterm	DerRadiologe.80380434.ger.abstr_task1	Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please typing these entity words according to sentence: Verletzungen, unteren Hohlvene, Komplikation, Fallbericht, Dissektion, Beckenvenenthrombose, Komplikation Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .	[ "Verletzungen", "der", "unteren", "Hohlvene", "sind", "eine", "seltene", "Komplikation", "gefaesschirurgischer", "Eingriffe", ".", "In", "einem", "Fallbericht", "werden", "die", "Dissektion", "und", "Perforation", "der", "V.", "cava", "inferior", "durch", "ein", "Fogarty", "-", "Ballonmanoever", "bei", "postoperativer", "Beckenvenenthrombose", "und", "der", "computertomo-", "sowie", "phlebographische", "Nachweis", "dieser", "Komplikation", "beschrieben", "." ]	[ "umlsterm" ]
Verletzungen, unteren Hohlvene, Komplikation, Fallbericht, Dissektion, Beckenvenenthrombose, Komplikation	DerRadiologe.80380434.ger.abstr_task2	Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .	[ "Verletzungen", "der", "unteren", "Hohlvene", "sind", "eine", "seltene", "Komplikation", "gefaesschirurgischer", "Eingriffe", ".", "In", "einem", "Fallbericht", "werden", "die", "Dissektion", "und", "Perforation", "der", "V.", "cava", "inferior", "durch", "ein", "Fogarty", "-", "Ballonmanoever", "bei", "postoperativer", "Beckenvenenthrombose", "und", "der", "computertomo-", "sowie", "phlebographische", "Nachweis", "dieser", "Komplikation", "beschrieben", "." ]	[ "umlsterm" ]
Tumoren is an umlsterm, Schaedelbasis is an umlsterm, Hirn- is an umlsterm, Gesichtsschaedel is an umlsterm, Behandlung is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Rezidiveingriffen is an umlsterm, Tumorexstirpation is an umlsterm, Lungenembolie is an umlsterm, neurologische Defizite is an umlsterm, Patienten is an umlsterm, Postoperative Komplikationen is an umlsterm, Tumorinvasion is an umlsterm, Operationstechniken is an umlsterm, Tumoranteile is an umlsterm, Tumorexstirpation is an umlsterm, Morbiditaet is an umlsterm, Knochens is an umlsterm, postoperative Komplikationen is an umlsterm, Behandlungsergebnis is an umlsterm	MundKieferGesichtschirurgie.8002s058.ger.abstr_task0	Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .	[ "Tumoren", "der", "frontalen", "Schaedelbasis", "entwickeln", "sich", "im", "Grenzgebiet", "von", "Hirn-", "und", "Gesichtsschaedel", "haeufig", "mit", "einer", "Ausbreitung", "nach", "intra-", "und", "extrakranial", ".", "Bei", "der", "operativen", "Behandlung", "wird", "diesen", "anatomischen", "Gegebenheiten", "durch", "kombinierte", "kraniofaziale", "Zugangswege", "Rechnung", "getragen", ",", "die", "von", "einem", "interdisziplinaeren", "Operationsteam", "durchgefuehrt", "werden", ".", "Um", "die", "Effektivitaet", "und", "Komplikationen", "dieses", "Behandlungskonzepts", "zu", "ueberpruefen", ",", "wurden", "die", "Daten", "von", "58", "Patienten", "aus", "den", "letzten", "10", "Jahren", "zusammengestellt", ".", "Bei", "diesen", "Patienten", "wurden", "mit", "2", "Rezidiveingriffen", "60", "Operationen", "durchgefuehrt", ".", "Bei", "38", "Eingriffen", "gelang", "eine", "vollstaendige", "Tumorexstirpation", ".", "Durch", "eine", "Lungenembolie", "ereignete", "sich", "ein", "postoperativer", "Todesfall", ".", "Funktionell", "relevante", "neurologische", "Defizite", "traten", "bei", "3", "Patienten", "auf", ".", "Postoperative", "Komplikationen", "und", "funktionelle", "Beeintraechtigungen", "wurden", "v.", "a.", "durch", "eine", "intradurale", "Tumorinvasion", "verursacht", ".", "Mit", "der", "Anwendung", "mikrochirurgischer", "Operationstechniken", "bei", "der", "Resektion", "der", "intraduralen", "Tumoranteile", "laesst", "sich", "meist", "eine", "radikale", "Tumorexstirpation", "bei", "akzeptabler", "Morbiditaet", "erreichen", ".", "Rekonstruktive", "Massnahmen", "bei", "Defekten", "im", "Bereich", "der", "Dura", "und", "des", "Knochens", "tragen", "entscheidend", "dazu", "bei", ",", "postoperative", "Komplikationen", "zu", "vermeiden", "und", "ein", "zufriedenstellendes", "kosmetisches", "Behandlungsergebnis", "zu", "erzielen", "." ]	[ "umlsterm" ]
Tumoren is an umlsterm, Schaedelbasis is an umlsterm, Hirn- is an umlsterm, Gesichtsschaedel is an umlsterm, Behandlung is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Rezidiveingriffen is an umlsterm, Tumorexstirpation is an umlsterm, Lungenembolie is an umlsterm, neurologische Defizite is an umlsterm, Patienten is an umlsterm, Postoperative Komplikationen is an umlsterm, Tumorinvasion is an umlsterm, Operationstechniken is an umlsterm, Tumoranteile is an umlsterm, Tumorexstirpation is an umlsterm, Morbiditaet is an umlsterm, Knochens is an umlsterm, postoperative Komplikationen is an umlsterm, Behandlungsergebnis is an umlsterm	MundKieferGesichtschirurgie.8002s058.ger.abstr_task1	Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please typing these entity words according to sentence: Tumoren, Schaedelbasis, Hirn-, Gesichtsschaedel, Behandlung, Komplikationen, Patienten, Patienten, Rezidiveingriffen, Tumorexstirpation, Lungenembolie, neurologische Defizite, Patienten, Postoperative Komplikationen, Tumorinvasion, Operationstechniken, Tumoranteile, Tumorexstirpation, Morbiditaet, Knochens, postoperative Komplikationen, Behandlungsergebnis Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .	[ "Tumoren", "der", "frontalen", "Schaedelbasis", "entwickeln", "sich", "im", "Grenzgebiet", "von", "Hirn-", "und", "Gesichtsschaedel", "haeufig", "mit", "einer", "Ausbreitung", "nach", "intra-", "und", "extrakranial", ".", "Bei", "der", "operativen", "Behandlung", "wird", "diesen", "anatomischen", "Gegebenheiten", "durch", "kombinierte", "kraniofaziale", "Zugangswege", "Rechnung", "getragen", ",", "die", "von", "einem", "interdisziplinaeren", "Operationsteam", "durchgefuehrt", "werden", ".", "Um", "die", "Effektivitaet", "und", "Komplikationen", "dieses", "Behandlungskonzepts", "zu", "ueberpruefen", ",", "wurden", "die", "Daten", "von", "58", "Patienten", "aus", "den", "letzten", "10", "Jahren", "zusammengestellt", ".", "Bei", "diesen", "Patienten", "wurden", "mit", "2", "Rezidiveingriffen", "60", "Operationen", "durchgefuehrt", ".", "Bei", "38", "Eingriffen", "gelang", "eine", "vollstaendige", "Tumorexstirpation", ".", "Durch", "eine", "Lungenembolie", "ereignete", "sich", "ein", "postoperativer", "Todesfall", ".", "Funktionell", "relevante", "neurologische", "Defizite", "traten", "bei", "3", "Patienten", "auf", ".", "Postoperative", "Komplikationen", "und", "funktionelle", "Beeintraechtigungen", "wurden", "v.", "a.", "durch", "eine", "intradurale", "Tumorinvasion", "verursacht", ".", "Mit", "der", "Anwendung", "mikrochirurgischer", "Operationstechniken", "bei", "der", "Resektion", "der", "intraduralen", "Tumoranteile", "laesst", "sich", "meist", "eine", "radikale", "Tumorexstirpation", "bei", "akzeptabler", "Morbiditaet", "erreichen", ".", "Rekonstruktive", "Massnahmen", "bei", "Defekten", "im", "Bereich", "der", "Dura", "und", "des", "Knochens", "tragen", "entscheidend", "dazu", "bei", ",", "postoperative", "Komplikationen", "zu", "vermeiden", "und", "ein", "zufriedenstellendes", "kosmetisches", "Behandlungsergebnis", "zu", "erzielen", "." ]	[ "umlsterm" ]
Tumoren, Schaedelbasis, Hirn-, Gesichtsschaedel, Behandlung, Komplikationen, Patienten, Patienten, Rezidiveingriffen, Tumorexstirpation, Lungenembolie, neurologische Defizite, Patienten, Postoperative Komplikationen, Tumorinvasion, Operationstechniken, Tumoranteile, Tumorexstirpation, Morbiditaet, Knochens, postoperative Komplikationen, Behandlungsergebnis	MundKieferGesichtschirurgie.8002s058.ger.abstr_task2	Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .	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interleukin 2 is a Protein, interleukin 2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, GalNAc is a Entity, Gal(beta 1 - 3)GalNAc is a Entity, Thr is a Entity, IL-2 is a Protein, beta - galactoside alpha-2,3-sialyltransferase is a Protein, IL-2 is a Protein, interferon - beta is a Protein	552_task0	Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.	[ "Biosynthesis", "and", "secretion", "of", "human", "interleukin", "2", "glycoprotein", "variants", "from", "baculovirus", "-", "infected", "Sf21", "cells", ".", " ", "Characterization", "of", "polypeptides", "and", "posttranslational", "modifications", ".", "\n", "Human", "interleukin", "2", "(", "IL-2", ")", "and", "human", "IL-2", "mutant", "proteins", ",", "with", "artificially", "introduced", "N", "-", "glycosylation", "or", "O", "-", "glycosylation", "sites", ",", "have", "been", "expressed", "in", "a", "lepidopteran", "cell", "line", "(", "Sf21", ",", "Spodoptera", "frugiperda", ")", "using", "recombinant", "baculovirus", "vectors", ".", "Only", "approximately", "25", "%", "of", "the", "total", "recombinant", "IL-2", "protein", "synthesized", "by", "Sf21", "cells", "was", "secreted", "into", "the", "culture", "medium", ".", "Significant", "N", "-", "terminal", "truncations", "were", "detected", "in", "the", "secreted", "polypeptides", "(", "up", "to", "85", "%", "of", "the", "molecules", ")", ".", "Alanine", "and", "proline", "were", "absent", "in", "the", "major", "truncated", "forms", ";", "the", "first", "3", "-", "5", "amino", "acids", "were", "also", "absent", "in", "a", "small", "proportion", "of", "the", "purified", "proteins", ".", "The", "introduction", "of", "potential", "artificial", "O", "-", "glycosylation", "peptide", "sequences", "(", "..", "GGKAPTPPPK", "..", ")", ",", "to", "the", "C", "-", "terminus", "or", "between", "positions", "80", "and", "81", "of", "the", "IL-2", "polypeptide", "chain", ",", "resulted", "in", "the", "secretion", "of", "unglycosylated", "and", "O", "-", "glycosylated", "variant", "forms", ".", "Fast", "atom", "bombardment", "mass", "spectrometry", ",", "compositional", "analysis", "and", "methylation", "analysis", ",", "of", "the", "tryptic", "glycopeptide", "APTPPPK", ",", "revealed", "the", "presence", "of", "either", "GalNAc", "or", "the", "disaccharide", "Gal(beta", "1", "-", "3)GalNAc", "as", "the", "only", "carbohydrate", "constituents", "attached", "exclusively", "to", "Thr", "in", "this", "peptide", ",", "in", "a", "specific", "ratio", "for", "each", "individual", "IL-2", "mutant", "protein", ".", "The", "Gal(beta", "1", "-", "3)GalNAc", "protein", "forms", "could", "be", "partially", "altered", "in", "vitro", "to", "mammalian", "-", "type", "glycoforms", "by", "porcine", "liver", "beta", "-", "galactoside", "alpha-2,3-sialyltransferase", "in", "the", "presence", "of", "CMP", "-", "N", "-", "acetylneuraminic", "acid", ".", "An", "IL-2", "mutant", "form", ",", "with", "an", "11-amino", "-", "acid", "peptide", "of", "human", "interferon", "-", "beta", "at", "position", "4", ",", "which", "includes", "its", "only", "N", "-", "glycosylation", "site", ",", "had", "exclusively", "truncated", "proximally", "fucosylated", "oligomannosidic", "glycans", ";", "Man3GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "or", "Man2GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "structures", ",", "in", "a", "ratio", "of", "3:1", ",", "were", "detected", "in", "the", "secreted", "proteins", ".", "No", "evidence", "was", "obtained", "for", "the", "presence", "of", "secreted", "proteins", "with", "complex", "oligosaccharide", "chains", ",", "irrespective", "of", "the", "cell", "-", "culture", "conditions", "used", "or", "the", "harvesting", "time", ",", "for", "infected", "cells", "with", "recombinant", "baculovirus", "constructs", ".", "\n" ]	[ "Protein", "Entity" ]
interleukin 2 is a Protein, interleukin 2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, GalNAc is a Entity, Gal(beta 1 - 3)GalNAc is a Entity, Thr is a Entity, IL-2 is a Protein, beta - galactoside alpha-2,3-sialyltransferase is a Protein, IL-2 is a Protein, interferon - beta is a Protein	552_task1	Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please typing these entity words according to sentence: interleukin 2, interleukin 2, IL-2, IL-2, IL-2, IL-2, GalNAc, Gal(beta 1 - 3)GalNAc, Thr, IL-2, beta - galactoside alpha-2,3-sialyltransferase, IL-2, interferon - beta Options: Entity, Protein	[ "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.	[ "Biosynthesis", "and", "secretion", "of", "human", "interleukin", "2", "glycoprotein", "variants", "from", "baculovirus", "-", "infected", "Sf21", "cells", ".", " ", "Characterization", "of", "polypeptides", "and", "posttranslational", "modifications", ".", "\n", "Human", "interleukin", "2", "(", "IL-2", ")", "and", "human", "IL-2", "mutant", "proteins", ",", "with", "artificially", "introduced", "N", "-", "glycosylation", "or", "O", "-", "glycosylation", "sites", ",", "have", "been", "expressed", "in", "a", "lepidopteran", "cell", "line", "(", "Sf21", ",", "Spodoptera", "frugiperda", ")", "using", "recombinant", "baculovirus", "vectors", ".", "Only", "approximately", "25", "%", "of", "the", "total", "recombinant", "IL-2", "protein", "synthesized", "by", "Sf21", "cells", "was", "secreted", "into", "the", "culture", "medium", ".", "Significant", "N", "-", "terminal", "truncations", "were", "detected", "in", "the", "secreted", "polypeptides", "(", "up", "to", "85", "%", "of", "the", "molecules", ")", ".", "Alanine", "and", "proline", "were", "absent", "in", "the", "major", "truncated", "forms", ";", "the", "first", "3", "-", "5", "amino", "acids", "were", "also", "absent", "in", "a", "small", "proportion", "of", "the", "purified", "proteins", ".", "The", "introduction", "of", "potential", "artificial", "O", "-", "glycosylation", "peptide", "sequences", "(", "..", "GGKAPTPPPK", "..", ")", ",", "to", "the", "C", "-", "terminus", "or", "between", "positions", "80", "and", "81", "of", "the", "IL-2", "polypeptide", "chain", ",", "resulted", "in", "the", "secretion", "of", "unglycosylated", "and", "O", "-", "glycosylated", "variant", "forms", ".", "Fast", "atom", "bombardment", "mass", "spectrometry", ",", "compositional", "analysis", "and", "methylation", "analysis", ",", "of", "the", "tryptic", "glycopeptide", "APTPPPK", ",", "revealed", "the", "presence", "of", "either", "GalNAc", "or", "the", "disaccharide", "Gal(beta", "1", "-", "3)GalNAc", "as", "the", "only", "carbohydrate", "constituents", "attached", "exclusively", "to", "Thr", "in", "this", "peptide", ",", "in", "a", "specific", "ratio", "for", "each", "individual", "IL-2", "mutant", "protein", ".", "The", "Gal(beta", "1", "-", "3)GalNAc", "protein", "forms", "could", "be", "partially", "altered", "in", "vitro", "to", "mammalian", "-", "type", "glycoforms", "by", "porcine", "liver", "beta", "-", "galactoside", "alpha-2,3-sialyltransferase", "in", "the", "presence", "of", "CMP", "-", "N", "-", "acetylneuraminic", "acid", ".", "An", "IL-2", "mutant", "form", ",", "with", "an", "11-amino", "-", "acid", "peptide", "of", "human", "interferon", "-", "beta", "at", "position", "4", ",", "which", "includes", "its", "only", "N", "-", "glycosylation", "site", ",", "had", "exclusively", "truncated", "proximally", "fucosylated", "oligomannosidic", "glycans", ";", "Man3GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "or", "Man2GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "structures", ",", "in", "a", "ratio", "of", "3:1", ",", "were", "detected", "in", "the", "secreted", "proteins", ".", "No", "evidence", "was", "obtained", "for", "the", "presence", "of", "secreted", "proteins", "with", "complex", "oligosaccharide", "chains", ",", "irrespective", "of", "the", "cell", "-", "culture", "conditions", "used", "or", "the", "harvesting", "time", ",", "for", "infected", "cells", "with", "recombinant", "baculovirus", "constructs", ".", "\n" ]	[ "Protein", "Entity" ]
interleukin 2, interleukin 2, IL-2, IL-2, IL-2, IL-2, GalNAc, Gal(beta 1 - 3)GalNAc, Thr, IL-2, beta - galactoside alpha-2,3-sialyltransferase, IL-2, interferon - beta	552_task2	Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.	[ "Biosynthesis", "and", "secretion", "of", "human", "interleukin", "2", "glycoprotein", "variants", "from", "baculovirus", "-", "infected", "Sf21", "cells", ".", " ", "Characterization", "of", "polypeptides", "and", "posttranslational", "modifications", ".", "\n", "Human", "interleukin", "2", "(", "IL-2", ")", "and", "human", "IL-2", "mutant", "proteins", ",", "with", "artificially", "introduced", "N", "-", "glycosylation", "or", "O", "-", "glycosylation", "sites", ",", "have", "been", "expressed", "in", "a", "lepidopteran", "cell", "line", "(", "Sf21", ",", "Spodoptera", "frugiperda", ")", "using", "recombinant", "baculovirus", "vectors", ".", "Only", "approximately", "25", "%", "of", "the", "total", "recombinant", "IL-2", "protein", "synthesized", "by", "Sf21", "cells", "was", "secreted", "into", "the", "culture", "medium", ".", "Significant", "N", "-", "terminal", "truncations", "were", "detected", "in", "the", "secreted", "polypeptides", "(", "up", "to", "85", "%", "of", "the", "molecules", ")", ".", "Alanine", "and", "proline", "were", "absent", "in", "the", "major", "truncated", "forms", ";", "the", "first", "3", "-", "5", "amino", "acids", "were", "also", "absent", "in", "a", "small", "proportion", "of", "the", "purified", "proteins", ".", "The", "introduction", "of", "potential", "artificial", "O", "-", "glycosylation", "peptide", "sequences", "(", "..", "GGKAPTPPPK", "..", ")", ",", "to", "the", "C", "-", "terminus", "or", "between", "positions", "80", "and", "81", "of", "the", "IL-2", "polypeptide", "chain", ",", "resulted", "in", "the", "secretion", "of", "unglycosylated", "and", "O", "-", "glycosylated", "variant", "forms", ".", "Fast", "atom", "bombardment", "mass", "spectrometry", ",", "compositional", "analysis", "and", "methylation", "analysis", ",", "of", "the", "tryptic", "glycopeptide", "APTPPPK", ",", "revealed", "the", "presence", "of", "either", "GalNAc", "or", "the", "disaccharide", "Gal(beta", "1", "-", "3)GalNAc", "as", "the", "only", "carbohydrate", "constituents", "attached", "exclusively", "to", "Thr", "in", "this", "peptide", ",", "in", "a", "specific", "ratio", "for", "each", "individual", "IL-2", "mutant", "protein", ".", "The", "Gal(beta", "1", "-", "3)GalNAc", "protein", "forms", "could", "be", "partially", "altered", "in", "vitro", "to", "mammalian", "-", "type", "glycoforms", "by", "porcine", "liver", "beta", "-", "galactoside", "alpha-2,3-sialyltransferase", "in", "the", "presence", "of", "CMP", "-", "N", "-", "acetylneuraminic", "acid", ".", "An", "IL-2", "mutant", "form", ",", "with", "an", "11-amino", "-", "acid", "peptide", "of", "human", "interferon", "-", "beta", "at", "position", "4", ",", "which", "includes", "its", "only", "N", "-", "glycosylation", "site", ",", "had", "exclusively", "truncated", "proximally", "fucosylated", "oligomannosidic", "glycans", ";", "Man3GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "or", "Man2GlcNAc[Fuc(alpha", "1", "-", "6)]GlcNAc", "structures", ",", "in", "a", "ratio", "of", "3:1", ",", "were", "detected", "in", "the", "secreted", "proteins", ".", "No", "evidence", "was", "obtained", "for", "the", "presence", "of", "secreted", "proteins", "with", "complex", "oligosaccharide", "chains", ",", "irrespective", "of", "the", "cell", "-", "culture", "conditions", "used", "or", "the", "harvesting", "time", ",", "for", "infected", "cells", "with", "recombinant", "baculovirus", "constructs", ".", "\n" ]	[ "Protein", "Entity" ]
patients is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, traumatic rupture is an umlsterm, vaccination is an umlsterm, patient is an umlsterm, health is an umlsterm, patients is an umlsterm, therapy - resistant is an umlsterm, sepsis is an umlsterm, Streptococcus pneumoniae is an umlsterm, blood is an umlsterm, culture is an umlsterm, Autopsy is an umlsterm, findings is an umlsterm, syndrome is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, diagnosis is an umlsterm, syndrome is an umlsterm, sepsis is an umlsterm	DerPathologe.70180257.eng.abstr_task0	Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .	[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]	[ "umlsterm" ]
patients is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, traumatic rupture is an umlsterm, vaccination is an umlsterm, patient is an umlsterm, health is an umlsterm, patients is an umlsterm, therapy - resistant is an umlsterm, sepsis is an umlsterm, Streptococcus pneumoniae is an umlsterm, blood is an umlsterm, culture is an umlsterm, Autopsy is an umlsterm, findings is an umlsterm, syndrome is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, diagnosis is an umlsterm, syndrome is an umlsterm, sepsis is an umlsterm	DerPathologe.70180257.eng.abstr_task1	Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please typing these entity words according to sentence: patients, history, splenectomy, traumatic rupture, vaccination, patient, health, patients, therapy - resistant, sepsis, Streptococcus pneumoniae, blood, culture, Autopsy, findings, syndrome, history, splenectomy, diagnosis, syndrome, sepsis Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .	[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]	[ "umlsterm" ]
patients, history, splenectomy, traumatic rupture, vaccination, patient, health, patients, therapy - resistant, sepsis, Streptococcus pneumoniae, blood, culture, Autopsy, findings, syndrome, history, splenectomy, diagnosis, syndrome, sepsis	DerPathologe.70180257.eng.abstr_task2	Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .	[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]	[ "umlsterm" ]
villin is a Individual_protein, fimbrin is a Individual_protein, actin is a Individual_protein, calmodulin is a Individual_protein	735_task0	Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]	The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).	[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]	[ "Individual_protein" ]
villin is a Individual_protein, fimbrin is a Individual_protein, actin is a Individual_protein, calmodulin is a Individual_protein	735_task1	Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please typing these entity words according to sentence: villin, fimbrin, actin, calmodulin Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]	The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).	[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]	[ "Individual_protein" ]
villin, fimbrin, actin, calmodulin	735_task2	Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]	The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).	[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]	[ "Individual_protein" ]
pentoxifylline is a CHEMICAL	16426349_task0	Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.	[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]	[ "GENE-Y", "CHEMICAL" ]
pentoxifylline is a CHEMICAL	16426349_task1	Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please typing these entity words according to sentence: pentoxifylline Options: CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.	[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]	[ "GENE-Y", "CHEMICAL" ]
pentoxifylline	16426349_task2	Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.	[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]	[ "GENE-Y", "CHEMICAL" ]
propionate is a compound, fumarate is a compound, hydrogenase is a protein, formate dehydrogenase is a protein	DS.d1187_task0	Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]	[ "protein", "compound" ]
propionate is a compound, fumarate is a compound, hydrogenase is a protein, formate dehydrogenase is a protein	DS.d1187_task1	Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please typing these entity words according to sentence: propionate, fumarate, hydrogenase, formate dehydrogenase Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]	[ "protein", "compound" ]
propionate, fumarate, hydrogenase, formate dehydrogenase	DS.d1187_task2	Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]	[ "protein", "compound" ]
IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, CXCL8 is a Protein	208_task0	Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.	[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]	[ "Protein" ]
IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, CXCL8 is a Protein	208_task1	Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please typing these entity words according to sentence: IL-6, CXCL8, CXCL8, CXCL8, IL-6, IL-6, CXCL8, CXCL8, IL-6, CXCL8 Options: Protein	[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.	[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]	[ "Protein" ]
IL-6, CXCL8, CXCL8, CXCL8, IL-6, IL-6, CXCL8, CXCL8, IL-6, CXCL8	208_task2	Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.	[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]	[ "Protein" ]
Sectio caesarea is an umlsterm, Hypertropher Obstruktiver Kardiomyopathie is an umlsterm	DerAnaesthesist.00490527.ger.abstr_task0	Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .	[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]	[ "umlsterm" ]
Sectio caesarea is an umlsterm, Hypertropher Obstruktiver Kardiomyopathie is an umlsterm	DerAnaesthesist.00490527.ger.abstr_task1	Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please typing these entity words according to sentence: Sectio caesarea, Hypertropher Obstruktiver Kardiomyopathie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .	[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]	[ "umlsterm" ]
Sectio caesarea, Hypertropher Obstruktiver Kardiomyopathie	DerAnaesthesist.00490527.ger.abstr_task2	Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .	[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, Injuries is an umlsterm, posterior cruciate ligament is an umlsterm, injuries is an umlsterm, knee joint is an umlsterm, diagnosis is an umlsterm, injury is an umlsterm, treatment is an umlsterm, goal is an umlsterm, review is an umlsterm, anatomy is an umlsterm, biomechanics is an umlsterm, injury is an umlsterm, pathobiomechanics is an umlsterm, literature is an umlsterm, goal is an umlsterm, diagnostic is an umlsterm, clinical examination is an umlsterm, imaging techniques is an umlsterm, posterior cruciate ligament is an umlsterm, knees is an umlsterm, injuries is an umlsterm, anterior cruciate ligament is an umlsterm, injuries is an umlsterm, aim is an umlsterm	DerChirurg.00711066.eng.abstr_task0	Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .	[ "Abstract", ".", "Injuries", "to", "the", "posterior", "cruciate", "ligament", "are", "among", "the", "major", "injuries", "to", "the", "knee", "joint", ".", "Today", "we", "are", "often", "confronted", "with", "an", "inapproprate", "and", "delayed", "diagnosis", "of", "this", "injury", "and", "its", "concomitant", "lesions", ".", "Additionally", ",", "the", "outcome", "of", "operative", "treatment", "has", "not", "yet", "reached", "an", "acceptable", "rate", "of", "satisfactory", "results", ".", "Therefore", ",", "the", "goal", "of", "this", "current", "concept", "review", "is", "to", "give", "a", "comprehensive", "insight", "into", "anatomy", "and", "biomechanics", ",", "injury", "mechanisms", "and", "pathobiomechanics", ",", "based", "on", "our", "experiences", "and", "data", "from", "the", "international", "literature", ".", "A", "further", "goal", "is", "to", "clarify", "diagnostic", "problems", "with", "respect", "to", "clinical", "examination", "and", "imaging", "techniques", ".", "We", "also", "present", "a", "differential", "concept", "for", "the", "perioperative", "and", "conservative", "management", "of", "posterior", "cruciate", "ligament", "deficient", "knees", "in", "order", "to", "also", "adequately", "address", "concomitant", "injuries", "such", "as", "posterolateral", "rotatory", "instability", "and", "combined", "anterior", "cruciate", "ligament", "injuries", "with", "the", "aim", "of", "further", "improving", "results", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, Injuries is an umlsterm, posterior cruciate ligament is an umlsterm, injuries is an umlsterm, knee joint is an umlsterm, diagnosis is an umlsterm, injury is an umlsterm, treatment is an umlsterm, goal is an umlsterm, review is an umlsterm, anatomy is an umlsterm, biomechanics is an umlsterm, injury is an umlsterm, pathobiomechanics is an umlsterm, literature is an umlsterm, goal is an umlsterm, diagnostic is an umlsterm, clinical examination is an umlsterm, imaging techniques is an umlsterm, posterior cruciate ligament is an umlsterm, knees is an umlsterm, injuries is an umlsterm, anterior cruciate ligament is an umlsterm, injuries is an umlsterm, aim is an umlsterm	DerChirurg.00711066.eng.abstr_task1	Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please typing these entity words according to sentence: Abstract, Injuries, posterior cruciate ligament, injuries, knee joint, diagnosis, injury, treatment, goal, review, anatomy, biomechanics, injury, pathobiomechanics, literature, goal, diagnostic, clinical examination, imaging techniques, posterior cruciate ligament, knees, injuries, anterior cruciate ligament, injuries, aim Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .	[ "Abstract", ".", "Injuries", "to", "the", "posterior", "cruciate", "ligament", "are", "among", "the", "major", "injuries", "to", "the", "knee", "joint", ".", "Today", "we", "are", "often", "confronted", "with", "an", "inapproprate", "and", "delayed", "diagnosis", "of", "this", "injury", "and", "its", "concomitant", "lesions", ".", "Additionally", ",", "the", "outcome", "of", "operative", "treatment", "has", "not", "yet", "reached", "an", "acceptable", "rate", "of", "satisfactory", "results", ".", "Therefore", ",", "the", "goal", "of", "this", "current", "concept", "review", "is", "to", "give", "a", "comprehensive", "insight", "into", "anatomy", "and", "biomechanics", ",", "injury", "mechanisms", "and", "pathobiomechanics", ",", "based", "on", "our", "experiences", "and", "data", "from", "the", "international", "literature", ".", "A", "further", "goal", "is", "to", "clarify", "diagnostic", "problems", "with", "respect", "to", "clinical", "examination", "and", "imaging", "techniques", ".", "We", "also", "present", "a", "differential", "concept", "for", "the", "perioperative", "and", "conservative", "management", "of", "posterior", "cruciate", "ligament", "deficient", "knees", "in", "order", "to", "also", "adequately", "address", "concomitant", "injuries", "such", "as", "posterolateral", "rotatory", "instability", "and", "combined", "anterior", "cruciate", "ligament", "injuries", "with", "the", "aim", "of", "further", "improving", "results", "." ]	[ "umlsterm" ]
Abstract, Injuries, posterior cruciate ligament, injuries, knee joint, diagnosis, injury, treatment, goal, review, anatomy, biomechanics, injury, pathobiomechanics, literature, goal, diagnostic, clinical examination, imaging techniques, posterior cruciate ligament, knees, injuries, anterior cruciate ligament, injuries, aim	DerChirurg.00711066.eng.abstr_task2	Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .	[ "Abstract", ".", "Injuries", "to", "the", "posterior", "cruciate", "ligament", "are", "among", "the", "major", "injuries", "to", "the", "knee", "joint", ".", "Today", "we", "are", "often", "confronted", "with", "an", "inapproprate", "and", "delayed", "diagnosis", "of", "this", "injury", "and", "its", "concomitant", "lesions", ".", "Additionally", ",", "the", "outcome", "of", "operative", "treatment", "has", "not", "yet", "reached", "an", "acceptable", "rate", "of", "satisfactory", "results", ".", "Therefore", ",", "the", "goal", "of", "this", "current", "concept", "review", "is", "to", "give", "a", "comprehensive", "insight", "into", "anatomy", "and", "biomechanics", ",", "injury", "mechanisms", "and", "pathobiomechanics", ",", "based", "on", "our", "experiences", "and", "data", "from", "the", "international", "literature", ".", "A", "further", "goal", "is", "to", "clarify", "diagnostic", "problems", "with", "respect", "to", "clinical", "examination", "and", "imaging", "techniques", ".", "We", "also", "present", "a", "differential", "concept", "for", "the", "perioperative", "and", "conservative", "management", "of", "posterior", "cruciate", "ligament", "deficient", "knees", "in", "order", "to", "also", "adequately", "address", "concomitant", "injuries", "such", "as", "posterolateral", "rotatory", "instability", "and", "combined", "anterior", "cruciate", "ligament", "injuries", "with", "the", "aim", "of", "further", "improving", "results", "." ]	[ "umlsterm" ]
SERCA2 is a protein, M4 is a compound, oxygen is a compound, nitrogen is a compound	DS.d30_task0	Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O" ]	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	[ "Structure", "-", "function", "studies", "of", "nitrated", "SERCA2", "in", "aging", "heart", "and", "skeletal", "muscle", "demonstrate", "stoichiometric", "nitration", "of", "vicinal", "tyrosines", ",", "Tyr", "(", "294", ")", "and", "Tyr", "(", "295", ")", ",", "on", "the", "lumenal", "side", "of", "the", "membrane", "-", "spanning", "helix", ",", "M4", ",", "which", "correlates", "with", "partial", "inhibition", "of", "Ca(2+)-ATPase", "activity", "suggesting", "a", "possible", "regulatory", "function", "in", "down", "-", "regulating", "mitochondrial", "energy", "production", "and", "the", "associated", "generation", "of", "reactive", "oxygen", "/", "nitrogen", "species", "." ]	[ "compound", "protein" ]
SERCA2 is a protein, M4 is a compound, oxygen is a compound, nitrogen is a compound	DS.d30_task1	Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please typing these entity words according to sentence: SERCA2, M4, oxygen, nitrogen Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O" ]	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	[ "Structure", "-", "function", "studies", "of", "nitrated", "SERCA2", "in", "aging", "heart", "and", "skeletal", "muscle", "demonstrate", "stoichiometric", "nitration", "of", "vicinal", "tyrosines", ",", "Tyr", "(", "294", ")", "and", "Tyr", "(", "295", ")", ",", "on", "the", "lumenal", "side", "of", "the", "membrane", "-", "spanning", "helix", ",", "M4", ",", "which", "correlates", "with", "partial", "inhibition", "of", "Ca(2+)-ATPase", "activity", "suggesting", "a", "possible", "regulatory", "function", "in", "down", "-", "regulating", "mitochondrial", "energy", "production", "and", "the", "associated", "generation", "of", "reactive", "oxygen", "/", "nitrogen", "species", "." ]	[ "compound", "protein" ]
SERCA2, M4, oxygen, nitrogen	DS.d30_task2	Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O" ]	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	[ "Structure", "-", "function", "studies", "of", "nitrated", "SERCA2", "in", "aging", "heart", "and", "skeletal", "muscle", "demonstrate", "stoichiometric", "nitration", "of", "vicinal", "tyrosines", ",", "Tyr", "(", "294", ")", "and", "Tyr", "(", "295", ")", ",", "on", "the", "lumenal", "side", "of", "the", "membrane", "-", "spanning", "helix", ",", "M4", ",", "which", "correlates", "with", "partial", "inhibition", "of", "Ca(2+)-ATPase", "activity", "suggesting", "a", "possible", "regulatory", "function", "in", "down", "-", "regulating", "mitochondrial", "energy", "production", "and", "the", "associated", "generation", "of", "reactive", "oxygen", "/", "nitrogen", "species", "." ]	[ "compound", "protein" ]
Medizintechnologien is an umlsterm, Genetik is an umlsterm, Wachstum is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Aerzten is an umlsterm, Medizintechnik is an umlsterm, Medizin- is an umlsterm, berufsrechtlich is an umlsterm, Embryonenschutzgesetz is an umlsterm, Praeimplantationsdiagnostik is an umlsterm, Berufsrecht is an umlsterm, Genetik is an umlsterm, familien- is an umlsterm, Elternschaft is an umlsterm	Reproduktionsmedizin.00160140.ger.abstr_task0	Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .	[ "Die", "Synergieeffekte", "moderner", "Medizintechnologien", "in", "Fortpflanzungsmedizin", "und", "Genetik", "fuehren", "neben", "exponentiellem", "Wachstum", "der", "Moeglichkeiten", "in", "Diagnostik", ",", "Therapie", "und", "Praevention", "zur", "Notwendigkeit", "eines", "schnellen", "Wissenstransfers", "in", "die", "Oeffentlichkeit", ",", "um", "eine", "gesamtgesellschaftliche", "Konsensbildung", "herbeizufuehren", ".", "Aerzten", "und", "Wissenschaftlern", "kommt", "somit", "eine", "entscheidende", "Funktion", "nicht", "nur", "in", "der", "Fortentwicklung", "der", "Medizintechnik", ",", "sondern", "auch", "der", "Medizin-", "und", "Sozialethik", "zu", ".", "Die", "Bundesaerztekammer", "hat", "die", "Fortpflanzungsmedizin", "schon", "1984", "berufsrechtlich", "geregelt", "und", "seitdem", "staendig", "begleitet", ",", "darueber", "hinaus", "wurde", "vom", "Gesetzgeber", "1990", "die", "Notwendigkeit", "gesehen", ",", "eine", "bundesgesetzliche", "Regelung", "durch", "das", "Embryonenschutzgesetz", "zu", "schaffen", ".", "Heute", ",", "10", "Jahre", "spaeter", ",", "sind", "Aerzteschaft", "und", "Staat", "angesichts", "des", "gesamteuropaeischen", "Integrationsprozesses", "in", "unterschiedlichem", "Masse", "gefordert", ".", "Waehrend", "die", "Aerzteschaft", "kontinuierlich", "wie", "jetzt", "-", "fuer", "die", "Praeimplantationsdiagnostik", "-", "das", "Berufsrecht", "zu", "Fortpflanzungsmedizin", "und", "Genetik", "aktualisiert", ",", "ist", "es", "Sache", "des", "Bundesgesetzgebers", ",", "die", "primaer", "sozialrechtlich", "erforderlichen", "Rahmenbedingungen", "fuer", "eine", "ethisch", "vertretbare", "Fortpflanzungsmedizin", "-", "v.", "a.", "fuer", "Abstammungsrecht", ",", "Adoptionsvermittlungsgesetz", ",", "sowie", "familien-", "und", "erbrechtliche", "Fragen", "bei", "Auseinanderfallen", "genetischer", "und", "sozialer", "Elternschaft", "bei", "heterologer", "Befruchtung", "-", "zu", "entwickeln", "." ]	[ "umlsterm" ]
Medizintechnologien is an umlsterm, Genetik is an umlsterm, Wachstum is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Aerzten is an umlsterm, Medizintechnik is an umlsterm, Medizin- is an umlsterm, berufsrechtlich is an umlsterm, Embryonenschutzgesetz is an umlsterm, Praeimplantationsdiagnostik is an umlsterm, Berufsrecht is an umlsterm, Genetik is an umlsterm, familien- is an umlsterm, Elternschaft is an umlsterm	Reproduktionsmedizin.00160140.ger.abstr_task1	Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please typing these entity words according to sentence: Medizintechnologien, Genetik, Wachstum, Diagnostik, Therapie, Aerzten, Medizintechnik, Medizin-, berufsrechtlich, Embryonenschutzgesetz, Praeimplantationsdiagnostik, Berufsrecht, Genetik, familien-, Elternschaft Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .	[ "Die", "Synergieeffekte", "moderner", "Medizintechnologien", "in", "Fortpflanzungsmedizin", "und", "Genetik", "fuehren", "neben", "exponentiellem", "Wachstum", "der", "Moeglichkeiten", "in", "Diagnostik", ",", "Therapie", "und", "Praevention", "zur", "Notwendigkeit", "eines", "schnellen", "Wissenstransfers", "in", "die", "Oeffentlichkeit", ",", "um", "eine", "gesamtgesellschaftliche", "Konsensbildung", "herbeizufuehren", ".", "Aerzten", "und", "Wissenschaftlern", "kommt", "somit", "eine", "entscheidende", "Funktion", "nicht", "nur", "in", "der", "Fortentwicklung", "der", "Medizintechnik", ",", "sondern", "auch", "der", "Medizin-", "und", "Sozialethik", "zu", ".", "Die", "Bundesaerztekammer", "hat", "die", "Fortpflanzungsmedizin", "schon", "1984", "berufsrechtlich", "geregelt", "und", "seitdem", "staendig", "begleitet", ",", "darueber", "hinaus", "wurde", "vom", "Gesetzgeber", "1990", "die", "Notwendigkeit", "gesehen", ",", "eine", "bundesgesetzliche", "Regelung", "durch", "das", "Embryonenschutzgesetz", "zu", "schaffen", ".", "Heute", ",", "10", "Jahre", "spaeter", ",", "sind", "Aerzteschaft", "und", "Staat", "angesichts", "des", "gesamteuropaeischen", "Integrationsprozesses", "in", "unterschiedlichem", "Masse", "gefordert", ".", "Waehrend", "die", "Aerzteschaft", "kontinuierlich", "wie", "jetzt", "-", "fuer", "die", "Praeimplantationsdiagnostik", "-", "das", "Berufsrecht", "zu", "Fortpflanzungsmedizin", "und", "Genetik", "aktualisiert", ",", "ist", "es", "Sache", "des", "Bundesgesetzgebers", ",", "die", "primaer", "sozialrechtlich", "erforderlichen", "Rahmenbedingungen", "fuer", "eine", "ethisch", "vertretbare", "Fortpflanzungsmedizin", "-", "v.", "a.", "fuer", "Abstammungsrecht", ",", "Adoptionsvermittlungsgesetz", ",", "sowie", "familien-", "und", "erbrechtliche", "Fragen", "bei", "Auseinanderfallen", "genetischer", "und", "sozialer", "Elternschaft", "bei", "heterologer", "Befruchtung", "-", "zu", "entwickeln", "." ]	[ "umlsterm" ]
Medizintechnologien, Genetik, Wachstum, Diagnostik, Therapie, Aerzten, Medizintechnik, Medizin-, berufsrechtlich, Embryonenschutzgesetz, Praeimplantationsdiagnostik, Berufsrecht, Genetik, familien-, Elternschaft	Reproduktionsmedizin.00160140.ger.abstr_task2	Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .	[ "Die", "Synergieeffekte", "moderner", "Medizintechnologien", "in", "Fortpflanzungsmedizin", "und", "Genetik", "fuehren", "neben", "exponentiellem", "Wachstum", "der", "Moeglichkeiten", "in", "Diagnostik", ",", "Therapie", "und", "Praevention", "zur", "Notwendigkeit", "eines", "schnellen", "Wissenstransfers", "in", "die", "Oeffentlichkeit", ",", "um", "eine", "gesamtgesellschaftliche", "Konsensbildung", "herbeizufuehren", ".", "Aerzten", "und", "Wissenschaftlern", "kommt", "somit", "eine", "entscheidende", "Funktion", "nicht", "nur", "in", "der", "Fortentwicklung", "der", "Medizintechnik", ",", "sondern", "auch", "der", "Medizin-", "und", "Sozialethik", "zu", ".", "Die", "Bundesaerztekammer", "hat", "die", "Fortpflanzungsmedizin", "schon", "1984", "berufsrechtlich", "geregelt", "und", "seitdem", "staendig", "begleitet", ",", "darueber", "hinaus", "wurde", "vom", "Gesetzgeber", "1990", "die", "Notwendigkeit", "gesehen", ",", "eine", "bundesgesetzliche", "Regelung", "durch", "das", "Embryonenschutzgesetz", "zu", "schaffen", ".", "Heute", ",", "10", "Jahre", "spaeter", ",", "sind", "Aerzteschaft", "und", "Staat", "angesichts", "des", "gesamteuropaeischen", "Integrationsprozesses", "in", "unterschiedlichem", "Masse", "gefordert", ".", "Waehrend", "die", "Aerzteschaft", "kontinuierlich", "wie", "jetzt", "-", "fuer", "die", "Praeimplantationsdiagnostik", "-", "das", "Berufsrecht", "zu", "Fortpflanzungsmedizin", "und", "Genetik", "aktualisiert", ",", "ist", "es", "Sache", "des", "Bundesgesetzgebers", ",", "die", "primaer", "sozialrechtlich", "erforderlichen", "Rahmenbedingungen", "fuer", "eine", "ethisch", "vertretbare", "Fortpflanzungsmedizin", "-", "v.", "a.", "fuer", "Abstammungsrecht", ",", "Adoptionsvermittlungsgesetz", ",", "sowie", "familien-", "und", "erbrechtliche", "Fragen", "bei", "Auseinanderfallen", "genetischer", "und", "sozialer", "Elternschaft", "bei", "heterologer", "Befruchtung", "-", "zu", "entwickeln", "." ]	[ "umlsterm" ]
aerobic exercise is a Intervention_Physical, cognition is a Outcome_Mental, Alzheimer ' s disease is a Participant_Condition, ( is a Intervention_Physical, ) is a Intervention_Physical, Aerobic exercise is a Intervention_Physical, moderate - intensity cycling intervention is a Intervention_Physical, older adults is a Participant_Age, mild - to - moderate Alzheimer ' s disease is a Participant_Condition, cognitive decline is a Outcome_Mental, Ninety is a Participant_Sample-size, low - intensity stretching is a Intervention_Control, Alzheimer ' s disease Assessment Scale - Cognition is a Outcome_Mental, Hippocampal volume is a Outcome_Physical, 90 is a Participant_Sample-size, exercise efficacy is a Outcome_Other, physical function and quality of life is a Outcome_Other, prohibitive costs is a Outcome_Other	68290_task0	Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .	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aerobic exercise is a Intervention_Physical, cognition is a Outcome_Mental, Alzheimer ' s disease is a Participant_Condition, ( is a Intervention_Physical, ) is a Intervention_Physical, Aerobic exercise is a Intervention_Physical, moderate - intensity cycling intervention is a Intervention_Physical, older adults is a Participant_Age, mild - to - moderate Alzheimer ' s disease is a Participant_Condition, cognitive decline is a Outcome_Mental, Ninety is a Participant_Sample-size, low - intensity stretching is a Intervention_Control, Alzheimer ' s disease Assessment Scale - Cognition is a Outcome_Mental, Hippocampal volume is a Outcome_Physical, 90 is a Participant_Sample-size, exercise efficacy is a Outcome_Other, physical function and quality of life is a Outcome_Other, prohibitive costs is a Outcome_Other	68290_task1	Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please typing these entity words according to sentence: aerobic exercise, cognition, Alzheimer ' s disease, (, ), Aerobic exercise, moderate - intensity cycling intervention, older adults, mild - to - moderate Alzheimer ' s disease, cognitive decline, Ninety, low - intensity stretching, Alzheimer ' s disease Assessment Scale - Cognition, Hippocampal volume, 90, exercise efficacy, physical function and quality of life, prohibitive costs Options: Intervention_Physical, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .	[ "Effects", "of", "aerobic", "exercise", "on", "cognition", "and", "hippocampal", "volume", "in", "Alzheimer", "'", "s", "disease", ":", "study", "protocol", "of", "a", "randomized", "controlled", "trial", "(", "The", "FIT", "-", "AD", "trial", ")", ".", "BACKGROUND", "Alzheimer", "'", "s", "disease", ",", "a", "global", "public", "health", "issue", ",", "accounts", "for", "60", "to", "80", "%", "of", "all", "dementias", ".", "Alzheimer", "'", "s", "disease", "primarily", "causes", "cognitive", "impairment", "and", "drugs", "have", "only", "modest", "short", "-", "term", "effects", ",", "highlighting", "a", "pressing", "need", "to", "develop", "effective", "interventions", ".", "Aerobic", "exercise", "holds", "promise", "for", "treating", "cognitive", "impairment", "in", "Alzheimer", "'", "s", "disease", "through", "biologically", "sound", "mechanisms", ".", "Nonetheless", ",", "aerobic", "exercise", "studies", "in", "Alzheimer", "'", "s", "disease", "are", "limited", "with", "mixed", "findings", ".", "METHODS", "/", "DESIGN", "This", "pilot", "randomized", "controlled", "trial", "will", "investigate", "the", "effects", "of", "a", "6-month", ",", "individualized", ",", "moderate", "-", "intensity", "cycling", "intervention", "(", "20", "to", "50", "minutes", "per", "session", ",", "3", "times", "a", "week", ")", "on", "cognition", "and", "hippocampal", "volume", "in", "community", "-", "dwelling", "older", "adults", "with", "mild", "-", "to", "-", "moderate", "Alzheimer", "'", "s", "disease", ".", "The", "specific", "aims", "are", "to", ":", "1", ")", "determine", "the", "immediate", "effect", "of", "the", "cycling", "intervention", "on", "cognition", "in", "Alzheimer", "'", "s", "disease", ";", "2", ")", "examine", "if", "the", "cycling", "intervention", "slows", "cognitive", "decline", "in", "Alzheimer", "'", "s", "disease", "from", "baseline", "to", "12", "months", ";", "and", "3", ")", "assess", "the", "effect", "of", "aerobic", "exercise", "on", "hippocampal", "volume", "over", "12", "months", ".", "Ninety", "subjects", "will", "be", "randomized", "on", "a", "2:1", "allocation", "ratio", "to", "cycling", "or", "attention", "control", "(", "low", "-", "intensity", "stretching", ")", "and", "followed", "for", "another", "6", "months", ".", "Allocations", "will", "be", "concealed", "to", "all", "investigators", "and", "outcome", "assessors", "will", "be", "blinded", "to", "group", "assignments", "and", "previous", "data", ".", "Cognition", "will", "be", "measured", "by", "the", "Alzheimer", "'", "s", "disease", "Assessment", "Scale", "-", "Cognition", "at", "baseline", "before", "randomization", "and", "at", "3", ",", "6", ",", "9", ",", "and", "12", "months", ".", "Hippocampal", "volume", "will", "be", "measured", "by", "magnetic", "resonance", "imaging", "at", "baseline", "and", "6", "and", "12", "months", ".", "The", "sample", "size", "of", "90", "will", "give", "80", "%", "power", "to", "detect", "a", "2.5-point", "difference", "in", "within", "-", "group", "changes", "in", "the", "Alzheimer", "'", "s", "disease", "Assessment", "Scale", "-", "Cognition", "at", "6", "months", "for", "the", "cycling", "group", ".", "DISCUSSION", "Findings", "from", "this", "study", "will", "address", "the", "critical", "gap", "of", "exercise", "efficacy", "in", "Alzheimer", "'", "s", "disease", "and", "use", "of", "magnetic", "resonance", "imaging", "as", "an", "outcome", "measure", "in", "clinical", "trials", ".", "This", "study", "will", "provide", "a", "potential", "treatment", "that", "may", "increase", "physical", "function", "and", "quality", "of", "life", "and", "curb", "the", "prohibitive", "costs", "for", "the", "growing", "dementia", "population", ".", "TRIAL", "REGISTRATION", "Primary", "registration", ":", "(", "NCT01954550", ";", "date", "of", "registration", ":", "20", "September", "2013", ")", ".", "Secondary", "registration", ":", "(", "NCT01954550", ";", "date", "of", "registration", ":", "1", "October", "2013", ")", "." ]	[ "Outcome_Mental", "Intervention_Physical", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Outcome_Physical", "Participant_Age", "Participant_Sample-size" ]
aerobic exercise, cognition, Alzheimer ' s disease, (, ), Aerobic exercise, moderate - intensity cycling intervention, older adults, mild - to - moderate Alzheimer ' s disease, cognitive decline, Ninety, low - intensity stretching, Alzheimer ' s disease Assessment Scale - Cognition, Hippocampal volume, 90, exercise efficacy, physical function and quality of life, prohibitive costs	68290_task2	Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .	[ "Effects", "of", "aerobic", "exercise", "on", "cognition", "and", "hippocampal", "volume", "in", "Alzheimer", "'", "s", "disease", ":", "study", "protocol", "of", "a", "randomized", "controlled", "trial", "(", "The", "FIT", "-", "AD", "trial", ")", ".", "BACKGROUND", "Alzheimer", "'", "s", "disease", ",", "a", "global", "public", "health", "issue", ",", "accounts", "for", "60", "to", "80", "%", "of", "all", "dementias", ".", "Alzheimer", "'", "s", "disease", "primarily", "causes", "cognitive", "impairment", "and", "drugs", "have", "only", "modest", "short", "-", "term", "effects", ",", "highlighting", "a", "pressing", "need", "to", "develop", "effective", "interventions", ".", "Aerobic", "exercise", "holds", "promise", "for", "treating", "cognitive", "impairment", "in", "Alzheimer", "'", "s", "disease", "through", "biologically", "sound", "mechanisms", ".", "Nonetheless", ",", "aerobic", "exercise", "studies", "in", "Alzheimer", "'", "s", "disease", "are", "limited", "with", "mixed", "findings", ".", "METHODS", "/", "DESIGN", "This", "pilot", "randomized", "controlled", "trial", "will", "investigate", "the", "effects", "of", "a", "6-month", ",", "individualized", ",", "moderate", "-", "intensity", "cycling", "intervention", "(", "20", "to", "50", "minutes", "per", "session", ",", "3", "times", "a", "week", ")", "on", "cognition", "and", "hippocampal", "volume", "in", "community", "-", "dwelling", "older", "adults", "with", "mild", "-", "to", "-", "moderate", "Alzheimer", "'", "s", "disease", ".", "The", "specific", "aims", "are", "to", ":", "1", ")", "determine", "the", "immediate", "effect", "of", "the", "cycling", "intervention", "on", "cognition", "in", "Alzheimer", "'", "s", "disease", ";", "2", ")", "examine", "if", "the", "cycling", "intervention", "slows", "cognitive", "decline", "in", "Alzheimer", "'", "s", "disease", "from", "baseline", "to", "12", "months", ";", "and", "3", ")", "assess", "the", "effect", "of", "aerobic", "exercise", "on", "hippocampal", "volume", "over", "12", "months", ".", "Ninety", "subjects", "will", "be", "randomized", "on", "a", "2:1", "allocation", "ratio", "to", "cycling", "or", "attention", "control", "(", "low", "-", "intensity", "stretching", ")", "and", "followed", "for", "another", "6", "months", ".", "Allocations", "will", "be", "concealed", "to", "all", "investigators", "and", "outcome", "assessors", "will", "be", "blinded", "to", "group", "assignments", "and", "previous", "data", ".", "Cognition", "will", "be", "measured", "by", "the", "Alzheimer", "'", "s", "disease", "Assessment", "Scale", "-", "Cognition", "at", "baseline", "before", "randomization", "and", "at", "3", ",", "6", ",", "9", ",", "and", "12", "months", ".", "Hippocampal", "volume", "will", "be", "measured", "by", "magnetic", "resonance", "imaging", "at", "baseline", "and", "6", "and", "12", "months", ".", "The", "sample", "size", "of", "90", "will", "give", "80", "%", "power", "to", "detect", "a", "2.5-point", "difference", "in", "within", "-", "group", "changes", "in", "the", "Alzheimer", "'", "s", "disease", "Assessment", "Scale", "-", "Cognition", "at", "6", "months", "for", "the", "cycling", "group", ".", "DISCUSSION", "Findings", "from", "this", "study", "will", "address", "the", "critical", "gap", "of", "exercise", "efficacy", "in", "Alzheimer", "'", "s", "disease", "and", "use", "of", "magnetic", "resonance", "imaging", "as", "an", "outcome", "measure", "in", "clinical", "trials", ".", "This", "study", "will", "provide", "a", "potential", "treatment", "that", "may", "increase", "physical", "function", "and", "quality", "of", "life", "and", "curb", "the", "prohibitive", "costs", "for", "the", "growing", "dementia", "population", ".", "TRIAL", "REGISTRATION", "Primary", "registration", ":", "(", "NCT01954550", ";", "date", "of", "registration", ":", "20", "September", "2013", ")", ".", "Secondary", "registration", ":", "(", "NCT01954550", ";", "date", "of", "registration", ":", "1", "October", "2013", ")", "." ]	[ "Outcome_Mental", "Intervention_Physical", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Outcome_Physical", "Participant_Age", "Participant_Sample-size" ]
insulin is a Intervention_Pharmacological, whole - body protein turnover is a Outcome_Physical, parenterally - fed undernourished patients . is a Participant_Condition, Ten is a Participant_Sample-size, 1 - 2 units insulin / kg body weight/24 h with their feed is a Intervention_Pharmacological, received the feed only is a Intervention_Control, rates of whole - body protein synthesis and breakdown is a Outcome_Physical, 15N - glycine is a Intervention_Pharmacological, blood glucose is a Outcome_Physical, plasma insulin and glucagon is a Outcome_Physical, urinary ammonia is a Outcome_Physical, nitrogen is a Outcome_Physical, creatinine and 3-methylhistidine is a Outcome_Physical, Blood glucose is a Outcome_Physical, plasma insulin and glucagon concentrations is a Outcome_Physical, insulin concentration is a Outcome_Physical, Apparent nitrogen balance is a Outcome_Physical, urinary excretion of ammonia is a Outcome_Physical, Protein turnover is a Outcome_Physical, ammonia end - product is a Outcome_Physical	79142_task0	Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .	[ "The", "effect", "of", "surgical", "trauma", "and", "insulin", "on", "whole", "-", "body", "protein", "turnover", "in", "parenterally", "-", "fed", "undernourished", "patients", ".", "Ten", "undernourished", "patients", "receiving", "total", "parenteral", "nutrition", "and", "undergoing", "major", "intestinal", "surgery", "were", "restarted", "on", "intravenous", "feeds", "identical", "to", "their", "pre", "-", "operative", "regimens", "within", "24", "h", "of", "their", "operation", ".", "Five", ",", "chosen", "at", "random", ",", "received", "post", "-", "operatively", "1", "-", "2", "units", "insulin", "/", "kg", "body", "weight/24", "h", "with", "their", "feed", ",", "while", "the", "other", "five", "received", "the", "feed", "only", ".", "Pre", "-", "operatively", ",", "and", "2", "h", "after", "commencing", "their", "post", "-", "operative", "feeds", ",", "rates", "of", "whole", "-", "body", "protein", "synthesis", "and", "breakdown", "were", "measured", "over", "a", "9-h", "period", "following", "intravenous", "injection", "of", "a", "single", "tracer", "dose", "of", "15N", "-", "glycine", "by", "the", "ammonia", "and", "urea", "end", "-", "product", "methods", ".", "During", "these", "9-h", "study", "periods", "measurements", "were", "also", "made", "of", "blood", "glucose", ",", "plasma", "insulin", "and", "glucagon", ",", "urinary", "ammonia", ",", "nitrogen", ",", "creatinine", "and", "3-methylhistidine", ".", "Blood", "glucose", "and", "plasma", "insulin", "and", "glucagon", "concentrations", "rose", "post", "-", "operatively", "whether", "or", "not", "insulin", "was", "given", ",", "but", "the", "increment", "in", "insulin", "concentration", "was", "significantly", "greater", "when", "insulin", "was", "given", ".", "Apparent", "nitrogen", "balance", "was", "positive", "pre", "-", "operatively", "and", "became", "less", "so", "post", "-", "operatively", "whether", "insulin", "was", "given", "or", "not", ".", "Similarly", ",", "post", "-", "operative", "increments", "in", "urinary", "excretion", "of", "ammonia", ",", "creatinine", "and", "3-methylhistidine", "were", "not", "altered", "by", "addition", "of", "insulin", ".", "Protein", "turnover", ",", "as", "estimated", "by", "the", "ammonia", "end", "-", "product", "method", ",", "tended", "to", "rise", "post", "-", "operatively", ",", "but", "there", "was", "no", "significant", "difference", "between", "the", "increases", "observed", "with", "or", "without", "insulin", ".", "The", "urea", "end", "-", "product", "method", "suggested", "that", "there", "was", "no", "change", "in", "whole", "-", "body", "protein", "turnover", "after", "surgery", ",", "whether", "or", "not", "insulin", "was", "given", ".", "This", "study", "does", "not", "support", "the", "clinical", "use", "of", "insulin", "as", "a", "means", "of", "modifying", "protein", "metabolic", "losses", "after", "major", "surgery", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]
insulin is a Intervention_Pharmacological, whole - body protein turnover is a Outcome_Physical, parenterally - fed undernourished patients . is a Participant_Condition, Ten is a Participant_Sample-size, 1 - 2 units insulin / kg body weight/24 h with their feed is a Intervention_Pharmacological, received the feed only is a Intervention_Control, rates of whole - body protein synthesis and breakdown is a Outcome_Physical, 15N - glycine is a Intervention_Pharmacological, blood glucose is a Outcome_Physical, plasma insulin and glucagon is a Outcome_Physical, urinary ammonia is a Outcome_Physical, nitrogen is a Outcome_Physical, creatinine and 3-methylhistidine is a Outcome_Physical, Blood glucose is a Outcome_Physical, plasma insulin and glucagon concentrations is a Outcome_Physical, insulin concentration is a Outcome_Physical, Apparent nitrogen balance is a Outcome_Physical, urinary excretion of ammonia is a Outcome_Physical, Protein turnover is a Outcome_Physical, ammonia end - product is a Outcome_Physical	79142_task1	Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please typing these entity words according to sentence: insulin, whole - body protein turnover, parenterally - fed undernourished patients ., Ten, 1 - 2 units insulin / kg body weight/24 h with their feed, received the feed only, rates of whole - body protein synthesis and breakdown, 15N - glycine, blood glucose, plasma insulin and glucagon, urinary ammonia, nitrogen, creatinine and 3-methylhistidine, Blood glucose, plasma insulin and glucagon concentrations, insulin concentration, Apparent nitrogen balance, urinary excretion of ammonia, Protein turnover, ammonia end - product Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .	[ "The", "effect", "of", "surgical", "trauma", "and", "insulin", "on", "whole", "-", "body", "protein", "turnover", "in", "parenterally", "-", "fed", "undernourished", "patients", ".", "Ten", "undernourished", "patients", "receiving", "total", "parenteral", "nutrition", "and", "undergoing", "major", "intestinal", "surgery", "were", "restarted", "on", "intravenous", "feeds", "identical", "to", "their", "pre", "-", "operative", "regimens", "within", "24", "h", "of", "their", "operation", ".", "Five", ",", "chosen", "at", "random", ",", "received", "post", "-", "operatively", "1", "-", "2", "units", "insulin", "/", "kg", "body", "weight/24", "h", "with", "their", "feed", ",", "while", "the", "other", "five", "received", "the", "feed", "only", ".", "Pre", "-", "operatively", ",", "and", "2", "h", "after", "commencing", "their", "post", "-", "operative", "feeds", ",", "rates", "of", "whole", "-", "body", "protein", "synthesis", "and", "breakdown", "were", "measured", "over", "a", "9-h", "period", "following", "intravenous", "injection", "of", "a", "single", "tracer", "dose", "of", "15N", "-", "glycine", "by", "the", "ammonia", "and", "urea", "end", "-", "product", "methods", ".", "During", "these", "9-h", "study", "periods", "measurements", "were", "also", "made", "of", "blood", "glucose", ",", "plasma", "insulin", "and", "glucagon", ",", "urinary", "ammonia", ",", "nitrogen", ",", "creatinine", "and", "3-methylhistidine", ".", "Blood", "glucose", "and", "plasma", "insulin", "and", "glucagon", "concentrations", "rose", "post", "-", "operatively", "whether", "or", "not", "insulin", "was", "given", ",", "but", "the", "increment", "in", "insulin", "concentration", "was", "significantly", "greater", "when", "insulin", "was", "given", ".", "Apparent", "nitrogen", "balance", "was", "positive", "pre", "-", "operatively", "and", "became", "less", "so", "post", "-", "operatively", "whether", "insulin", "was", "given", "or", "not", ".", "Similarly", ",", "post", "-", "operative", "increments", "in", "urinary", "excretion", "of", "ammonia", ",", "creatinine", "and", "3-methylhistidine", "were", "not", "altered", "by", "addition", "of", "insulin", ".", "Protein", "turnover", ",", "as", "estimated", "by", "the", "ammonia", "end", "-", "product", "method", ",", "tended", "to", "rise", "post", "-", "operatively", ",", "but", "there", "was", "no", "significant", "difference", "between", "the", "increases", "observed", "with", "or", "without", "insulin", ".", "The", "urea", "end", "-", "product", "method", "suggested", "that", "there", "was", "no", "change", "in", "whole", "-", "body", "protein", "turnover", "after", "surgery", ",", "whether", "or", "not", "insulin", "was", "given", ".", "This", "study", "does", "not", "support", "the", "clinical", "use", "of", "insulin", "as", "a", "means", "of", "modifying", "protein", "metabolic", "losses", "after", "major", "surgery", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]
insulin, whole - body protein turnover, parenterally - fed undernourished patients ., Ten, 1 - 2 units insulin / kg body weight/24 h with their feed, received the feed only, rates of whole - body protein synthesis and breakdown, 15N - glycine, blood glucose, plasma insulin and glucagon, urinary ammonia, nitrogen, creatinine and 3-methylhistidine, Blood glucose, plasma insulin and glucagon concentrations, insulin concentration, Apparent nitrogen balance, urinary excretion of ammonia, Protein turnover, ammonia end - product	79142_task2	Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .	[ "The", "effect", "of", "surgical", "trauma", "and", "insulin", "on", "whole", "-", "body", "protein", "turnover", "in", "parenterally", "-", "fed", "undernourished", "patients", ".", "Ten", "undernourished", "patients", "receiving", "total", "parenteral", "nutrition", "and", "undergoing", "major", "intestinal", "surgery", "were", "restarted", "on", "intravenous", "feeds", "identical", "to", "their", "pre", "-", "operative", "regimens", "within", "24", "h", "of", "their", "operation", ".", "Five", ",", "chosen", "at", "random", ",", "received", "post", "-", "operatively", "1", "-", "2", "units", "insulin", "/", "kg", "body", "weight/24", "h", "with", "their", "feed", ",", "while", "the", "other", "five", "received", "the", "feed", "only", ".", "Pre", "-", "operatively", ",", "and", "2", "h", "after", "commencing", "their", "post", "-", "operative", "feeds", ",", "rates", "of", "whole", "-", "body", "protein", "synthesis", "and", "breakdown", "were", "measured", "over", "a", "9-h", "period", "following", "intravenous", "injection", "of", "a", "single", "tracer", "dose", "of", "15N", "-", "glycine", "by", "the", "ammonia", "and", "urea", "end", "-", "product", "methods", ".", "During", "these", "9-h", "study", "periods", "measurements", "were", "also", "made", "of", "blood", "glucose", ",", "plasma", "insulin", "and", "glucagon", ",", "urinary", "ammonia", ",", "nitrogen", ",", "creatinine", "and", "3-methylhistidine", ".", "Blood", "glucose", "and", "plasma", "insulin", "and", "glucagon", "concentrations", "rose", "post", "-", "operatively", "whether", "or", "not", "insulin", "was", "given", ",", "but", "the", "increment", "in", "insulin", "concentration", "was", "significantly", "greater", "when", "insulin", "was", "given", ".", "Apparent", "nitrogen", "balance", "was", "positive", "pre", "-", "operatively", "and", "became", "less", "so", "post", "-", "operatively", "whether", "insulin", "was", "given", "or", "not", ".", "Similarly", ",", "post", "-", "operative", "increments", "in", "urinary", "excretion", "of", "ammonia", ",", "creatinine", "and", "3-methylhistidine", "were", "not", "altered", "by", "addition", "of", "insulin", ".", "Protein", "turnover", ",", "as", "estimated", "by", "the", "ammonia", "end", "-", "product", "method", ",", "tended", "to", "rise", "post", "-", "operatively", ",", "but", "there", "was", "no", "significant", "difference", "between", "the", "increases", "observed", "with", "or", "without", "insulin", ".", "The", "urea", "end", "-", "product", "method", "suggested", "that", "there", "was", "no", "change", "in", "whole", "-", "body", "protein", "turnover", "after", "surgery", ",", "whether", "or", "not", "insulin", "was", "given", ".", "This", "study", "does", "not", "support", "the", "clinical", "use", "of", "insulin", "as", "a", "means", "of", "modifying", "protein", "metabolic", "losses", "after", "major", "surgery", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]
14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, phosphoserine is a Simple_chemical, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F2 is a Gene_or_gene_product, E2F3 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, p73 is a Gene_or_gene_product, Apaf-1 is a Gene_or_gene_product, caspases is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product	132_task0	Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Gene_or_gene_product	[ "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.	[ "A", "role", "for", "14", "-", "3", "-", "3", "tau", "in", "E2F1", "stabilization", "and", "DNA", "damage", "-", "induced", "apoptosis", ".", "\n", "Genotoxic", "stress", "triggers", "apoptosis", "through", "multiple", "signaling", "pathways", ".", "Recent", "studies", "have", "demonstrated", "a", "specific", "induction", "of", "E2F1", "accumulation", "and", "a", "role", "for", "E2F1", "in", "apoptosis", "upon", "DNA", "damage", ".", "Induction", "of", "E2F1", "is", "mediated", "by", "phosphorylation", "events", "that", "are", "dependent", "on", "DNA", "damage", "-", "responsive", "protein", "kinases", ",", "such", "as", "ATM", ".", "How", "ATM", "phosphorylation", "leads", "to", "E2F1", "stabilization", "is", "unknown", ".", "We", "now", "show", "that", "14", "-", "3", "-", "3", "tau", ",", "a", "phosphoserine", "-", "binding", "protein", ",", "mediates", "E2F1", "stabilization", ".", "14", "-", "3", "-", "3", "tau", "interacts", "with", "ATM", "-", "phosphorylated", "E2F1", "during", "DNA", "damage", "and", "inhibits", "E2F1", "ubiquitination", ".", "Depletion", "of", "14", "-", "3", "-", "3", "tau", "or", "E2F1", ",", "but", "not", "E2F2", "or", "E2F3", ",", "blocks", "adriamycin", "-", "induced", "apoptosis", ".", "14", "-", "3", "-", "3", "tau", "is", "also", "required", "for", "expression", "and", "induction", "of", "E2F1", "apoptotic", "targets", ",", "such", "as", "p73", ",", "Apaf-1", ",", "and", "caspases", ",", "during", "DNA", "damage", ".", "Together", ",", "these", "data", "demonstrate", "a", "novel", "function", "for", "14", "-", "3", "-", "3", "tau", "in", "the", "regulation", "of", "E2F1", "protein", "stability", "and", "apoptosis", "during", "DNA", "damage", ".", "\n" ]	[ "Simple_chemical", "Gene_or_gene_product" ]
14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, phosphoserine is a Simple_chemical, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F2 is a Gene_or_gene_product, E2F3 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, p73 is a Gene_or_gene_product, Apaf-1 is a Gene_or_gene_product, caspases is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product	132_task1	Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. Instructions: please typing these entity words according to sentence: 14 - 3 - 3 tau, E2F1, E2F1, E2F1, E2F1, ATM, ATM, E2F1, 14 - 3 - 3 tau, phosphoserine, E2F1, 14 - 3 - 3 tau, ATM, E2F1, E2F1, 14 - 3 - 3 tau, E2F1, E2F2, E2F3, 14 - 3 - 3 tau, E2F1, p73, Apaf-1, caspases, 14 - 3 - 3 tau, E2F1 Options: Simple_chemical, Gene_or_gene_product	[ "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Simple_chemical", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.	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14 - 3 - 3 tau, E2F1, E2F1, E2F1, E2F1, ATM, ATM, E2F1, 14 - 3 - 3 tau, phosphoserine, E2F1, 14 - 3 - 3 tau, ATM, E2F1, E2F1, 14 - 3 - 3 tau, E2F1, E2F2, E2F3, 14 - 3 - 3 tau, E2F1, p73, Apaf-1, caspases, 14 - 3 - 3 tau, E2F1	132_task2	Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. 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Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.	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Therapie is an umlsterm, radiologischen is an umlsterm, Arthrosegrad is an umlsterm, Behandlung is an umlsterm, bildgebender is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Synovialitis is an umlsterm	DerOrthopaede.90280812.ger.abstr_task0	Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . 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Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .	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Therapie is an umlsterm, radiologischen is an umlsterm, Arthrosegrad is an umlsterm, Behandlung is an umlsterm, bildgebender is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Synovialitis is an umlsterm	DerOrthopaede.90280812.ger.abstr_task1	Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . Instructions: please typing these entity words according to sentence: Therapie, radiologischen, Arthrosegrad, Behandlung, bildgebender, Patienten, Diagnostik, Synovialitis Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .	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Therapie, radiologischen, Arthrosegrad, Behandlung, bildgebender, Patienten, Diagnostik, Synovialitis	DerOrthopaede.90280812.ger.abstr_task2	Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .	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TGF - β is a GENE-N, cytokines is a GENE-N, chemokines is a GENE-N, Transforming growth factor beta is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, MAPK is a GENE-N, PI3 K is a GENE-N, WNT is a GENE-N, β - catenin is a GENE-Y, Ca(2 + ) is a CHEMICAL, TGF - β is a GENE-N	6988_task0	Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.	[ "Novel", "non", "-", "canonical", "TGF", "-", "β", "signaling", "networks", ":", "emerging", "roles", "in", "airway", "smooth", "muscle", "phenotype", "and", "function", ".", "\n", "The", "airway", "smooth", "muscle", "(", "ASM", ")", "plays", "an", "important", "role", "in", "the", "pathophysiology", "of", "asthma", "and", "chronic", "obstructive", "pulmonary", "disease", "(", "COPD", ")", ".", "ASM", "cells", "express", "a", "wide", "range", "of", "receptors", "involved", "in", "contraction", ",", "growth", ",", "matrix", "protein", "production", "and", "the", "secretion", "of", "cytokines", "and", "chemokines", ".", "Transforming", "growth", "factor", "beta", "(", "TGF", "-", "β", ")", "is", "one", "of", "the", "major", "players", "in", "determining", "the", "structural", "and", "functional", "abnormalities", "of", "the", "ASM", "in", "asthma", "and", "COPD", ".", "It", "is", "increasingly", "evident", "that", "TGF", "-", "β", "functions", "as", "a", "master", "switch", ",", "controlling", "a", "network", "of", "intracellular", "and", "autocrine", "signaling", "loops", "that", "effect", "ASM", "phenotype", "and", "function", ".", "In", "this", "review", ",", "the", "various", "elements", "that", "participate", "in", "non", "-", "canonical", "TGF", "-", "β", "signaling", ",", "including", "MAPK", ",", "PI3", "K", ",", "WNT", "/", "β", "-", "catenin", ",", "and", "Ca(2", "+", ")", ",", "are", "discussed", ",", "focusing", "on", "their", "effect", "on", "ASM", "phenotype", "and", "function", ".", "In", "addition", ",", "new", "aspects", "of", "ASM", "biology", "and", "their", "possible", "association", "with", "non", "-", "canonical", "TGF", "-", "β", "signaling", "will", "be", "discussed", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TGF - β is a GENE-N, cytokines is a GENE-N, chemokines is a GENE-N, Transforming growth factor beta is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, MAPK is a GENE-N, PI3 K is a GENE-N, WNT is a GENE-N, β - catenin is a GENE-Y, Ca(2 + ) is a CHEMICAL, TGF - β is a GENE-N	6988_task1	Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please typing these entity words according to sentence: TGF - β, cytokines, chemokines, Transforming growth factor beta, TGF - β, TGF - β, TGF - β, MAPK, PI3 K, WNT, β - catenin, Ca(2 + ), TGF - β Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.	[ "Novel", "non", "-", "canonical", "TGF", "-", "β", "signaling", "networks", ":", "emerging", "roles", "in", "airway", "smooth", "muscle", "phenotype", "and", "function", ".", "\n", "The", "airway", "smooth", "muscle", "(", "ASM", ")", "plays", "an", "important", "role", "in", "the", "pathophysiology", "of", "asthma", "and", "chronic", "obstructive", "pulmonary", "disease", "(", "COPD", ")", ".", "ASM", "cells", "express", "a", "wide", "range", "of", "receptors", "involved", "in", "contraction", ",", "growth", ",", "matrix", "protein", "production", "and", "the", "secretion", "of", "cytokines", "and", "chemokines", ".", "Transforming", "growth", "factor", "beta", "(", "TGF", "-", "β", ")", "is", "one", "of", "the", "major", "players", "in", "determining", "the", "structural", "and", "functional", "abnormalities", "of", "the", "ASM", "in", "asthma", "and", "COPD", ".", "It", "is", "increasingly", "evident", "that", "TGF", "-", "β", "functions", "as", "a", "master", "switch", ",", "controlling", "a", "network", "of", "intracellular", "and", "autocrine", "signaling", "loops", "that", "effect", "ASM", "phenotype", "and", "function", ".", "In", "this", "review", ",", "the", "various", "elements", "that", "participate", "in", "non", "-", "canonical", "TGF", "-", "β", "signaling", ",", "including", "MAPK", ",", "PI3", "K", ",", "WNT", "/", "β", "-", "catenin", ",", "and", "Ca(2", "+", ")", ",", "are", "discussed", ",", "focusing", "on", "their", "effect", "on", "ASM", "phenotype", "and", "function", ".", "In", "addition", ",", "new", "aspects", "of", "ASM", "biology", "and", "their", "possible", "association", "with", "non", "-", "canonical", "TGF", "-", "β", "signaling", "will", "be", "discussed", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TGF - β, cytokines, chemokines, Transforming growth factor beta, TGF - β, TGF - β, TGF - β, MAPK, PI3 K, WNT, β - catenin, Ca(2 + ), TGF - β	6988_task2	Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.	[ "Novel", "non", "-", "canonical", "TGF", "-", "β", "signaling", "networks", ":", "emerging", "roles", "in", "airway", "smooth", "muscle", "phenotype", "and", "function", ".", "\n", "The", "airway", "smooth", "muscle", "(", "ASM", ")", "plays", "an", "important", "role", "in", "the", "pathophysiology", "of", "asthma", "and", "chronic", "obstructive", "pulmonary", "disease", "(", "COPD", ")", ".", "ASM", "cells", "express", "a", "wide", "range", "of", "receptors", "involved", "in", "contraction", ",", "growth", ",", "matrix", "protein", "production", "and", "the", "secretion", "of", "cytokines", "and", "chemokines", ".", "Transforming", "growth", "factor", "beta", "(", "TGF", "-", "β", ")", "is", "one", "of", "the", "major", "players", "in", "determining", "the", "structural", "and", "functional", "abnormalities", "of", "the", "ASM", "in", "asthma", "and", "COPD", ".", "It", "is", "increasingly", "evident", "that", "TGF", "-", "β", "functions", "as", "a", "master", "switch", ",", "controlling", "a", "network", "of", "intracellular", "and", "autocrine", "signaling", "loops", "that", "effect", "ASM", "phenotype", "and", "function", ".", "In", "this", "review", ",", "the", "various", "elements", "that", "participate", "in", "non", "-", "canonical", "TGF", "-", "β", "signaling", ",", "including", "MAPK", ",", "PI3", "K", ",", "WNT", "/", "β", "-", "catenin", ",", "and", "Ca(2", "+", ")", ",", "are", "discussed", ",", "focusing", "on", "their", "effect", "on", "ASM", "phenotype", "and", "function", ".", "In", "addition", ",", "new", "aspects", "of", "ASM", "biology", "and", "their", "possible", "association", "with", "non", "-", "canonical", "TGF", "-", "β", "signaling", "will", "be", "discussed", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
female sterilization procedure is a Procedure, Desire is a Mood, conception is a Observation, in the next 12 months is a Temporal, Not is a Negation, sexually active is a Observation, male partner is a Qualifier	NCT02267616_exc_task0	Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Qualifier, Observation, Procedure, Negation, Mood	[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Negation", "B-Observation", "I-Observation", "O", "O", "B-Qualifier", "I-Qualifier", "O" ]	Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner	[ "Have", "history", "of", "female", "sterilization", "procedure", "\n", "Desire", "for", "conception", "in", "the", "next", "12", "months", "\n", "Not", "sexually", "active", "with", "a", "male", "partner", "\n" ]	[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]
female sterilization procedure is a Procedure, Desire is a Mood, conception is a Observation, in the next 12 months is a Temporal, Not is a Negation, sexually active is a Observation, male partner is a Qualifier	NCT02267616_exc_task1	Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please typing these entity words according to sentence: female sterilization procedure, Desire, conception, in the next 12 months, Not, sexually active, male partner Options: Temporal, Qualifier, Observation, Procedure, Negation, Mood	[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Negation", "B-Observation", "I-Observation", "O", "O", "B-Qualifier", "I-Qualifier", "O" ]	Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner	[ "Have", "history", "of", "female", "sterilization", "procedure", "\n", "Desire", "for", "conception", "in", "the", "next", "12", "months", "\n", "Not", "sexually", "active", "with", "a", "male", "partner", "\n" ]	[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]
female sterilization procedure, Desire, conception, in the next 12 months, Not, sexually active, male partner	NCT02267616_exc_task2	Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Negation", "B-Observation", "I-Observation", "O", "O", "B-Qualifier", "I-Qualifier", "O" ]	Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner	[ "Have", "history", "of", "female", "sterilization", "procedure", "\n", "Desire", "for", "conception", "in", "the", "next", "12", "months", "\n", "Not", "sexually", "active", "with", "a", "male", "partner", "\n" ]	[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]
diacylglycerol acyltransferase is a GENE-Y, prenylflavonoids is a CHEMICAL, prenylflavonoids is a CHEMICAL, kurarinone is a CHEMICAL, chalcone is a CHEMICAL, kuraridin is a CHEMICAL, kurarinol is a CHEMICAL, kushenol H is a CHEMICAL, kushenol K is a CHEMICAL, diacylglycerol acyltransferase is a GENE-Y, DGAT is a GENE-Y, flavonoids is a CHEMICAL, DGAT is a GENE-Y, prenylflavonoids is a CHEMICAL, C3-OH is a CHEMICAL, C3-OH is a CHEMICAL, flavonoids is a CHEMICAL, hesperetin is a CHEMICAL, naringenin is a CHEMICAL, quercetin is a CHEMICAL, kaempferol is a CHEMICAL, lavandulyl is a CHEMICAL, hydroxy is a CHEMICAL, DGAT is a GENE-Y, triacylglycerol is a CHEMICAL, TG is a CHEMICAL	30225_task0	Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.	[ "In", "vitro", "inhibition", "of", "diacylglycerol", "acyltransferase", "by", "prenylflavonoids", "from", "Sophora", "flavescens", ".", "\n", "Four", "prenylflavonoids", ",", "kurarinone", "(", "1", ")", ",", "a", "chalcone", "of", "1", ",", "kuraridin", "(", "2", ")", ",", "kurarinol", "(", "3", ")", ",", "kushenol", "H", "(", "4", ")", "and", "kushenol", "K", "(", "5", ")", "isolated", "from", "the", "roots", "of", "Sophora", "flavescens", "were", "investigated", "for", "their", "inhibitory", "effects", "on", "diacylglycerol", "acyltransferase", "(", "DGAT", ")", ".", "The", "flavonoids", "inhibited", "DGAT", "activity", "in", "a", "dose", "-", "dependent", "manner", "with", "IC50", "values", "of", "10.9", "microM", "(", "1", ")", ",", "9.8", "microM", "(", "2", ")", ",", "8.6", "microM", "(", "3", ")", ",", "142.0", "microM", "(", "4", ")", "and", "250", "microM", "(", "5", ")", ".", "The", "prenylflavonoids", "without", "C3-OH", "(", "1", ",", "2", ",", "3", ")", "showed", "stronger", "inhibition", "than", "those", "with", "C3-OH", "(", "4", ",", "5", ")", ".", "On", "the", "other", "hand", ",", "flavonoids", "without", "side", "chains", "(", "hesperetin", ",", "naringenin", ",", "quercetin", "and", "kaempferol", ")", "did", "not", "inhibit", "the", "enzyme", "activity", "at", "a", "final", "concentration", "of", "800", "microM.", "These", "data", "suggest", "that", "the", "lavandulyl", "side", "chain", "and", "the", "position", "of", "the", "hydroxy", "group", "are", "important", "for", "high", "DGAT", "inhibitory", "activity", ".", "Compound", "1", "also", "inhibited", "de", "novo", "synthesis", "of", "triacylglycerol", "(", "TG", ")", "in", "Raji", "cells", "." ]	[ "GENE-Y", "CHEMICAL" ]
diacylglycerol acyltransferase is a GENE-Y, prenylflavonoids is a CHEMICAL, prenylflavonoids is a CHEMICAL, kurarinone is a CHEMICAL, chalcone is a CHEMICAL, kuraridin is a CHEMICAL, kurarinol is a CHEMICAL, kushenol H is a CHEMICAL, kushenol K is a CHEMICAL, diacylglycerol acyltransferase is a GENE-Y, DGAT is a GENE-Y, flavonoids is a CHEMICAL, DGAT is a GENE-Y, prenylflavonoids is a CHEMICAL, C3-OH is a CHEMICAL, C3-OH is a CHEMICAL, flavonoids is a CHEMICAL, hesperetin is a CHEMICAL, naringenin is a CHEMICAL, quercetin is a CHEMICAL, kaempferol is a CHEMICAL, lavandulyl is a CHEMICAL, hydroxy is a CHEMICAL, DGAT is a GENE-Y, triacylglycerol is a CHEMICAL, TG is a CHEMICAL	30225_task1	Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please typing these entity words according to sentence: diacylglycerol acyltransferase, prenylflavonoids, prenylflavonoids, kurarinone, chalcone, kuraridin, kurarinol, kushenol H, kushenol K, diacylglycerol acyltransferase, DGAT, flavonoids, DGAT, prenylflavonoids, C3-OH, C3-OH, flavonoids, hesperetin, naringenin, quercetin, kaempferol, lavandulyl, hydroxy, DGAT, triacylglycerol, TG Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.	[ "In", "vitro", "inhibition", "of", "diacylglycerol", "acyltransferase", "by", "prenylflavonoids", "from", "Sophora", "flavescens", ".", "\n", "Four", "prenylflavonoids", ",", "kurarinone", "(", "1", ")", ",", "a", "chalcone", "of", "1", ",", "kuraridin", "(", "2", ")", ",", "kurarinol", "(", "3", ")", ",", "kushenol", "H", "(", "4", ")", "and", "kushenol", "K", "(", "5", ")", "isolated", "from", "the", "roots", "of", "Sophora", "flavescens", "were", "investigated", "for", "their", "inhibitory", "effects", "on", "diacylglycerol", "acyltransferase", "(", "DGAT", ")", ".", "The", "flavonoids", "inhibited", "DGAT", "activity", "in", "a", "dose", "-", "dependent", "manner", "with", "IC50", "values", "of", "10.9", "microM", "(", "1", ")", ",", "9.8", "microM", "(", "2", ")", ",", "8.6", "microM", "(", "3", ")", ",", "142.0", "microM", "(", "4", ")", "and", "250", "microM", "(", "5", ")", ".", "The", "prenylflavonoids", "without", "C3-OH", "(", "1", ",", "2", ",", "3", ")", "showed", "stronger", "inhibition", "than", "those", "with", "C3-OH", "(", "4", ",", "5", ")", ".", "On", "the", "other", "hand", ",", "flavonoids", "without", "side", "chains", "(", "hesperetin", ",", "naringenin", ",", "quercetin", "and", "kaempferol", ")", "did", "not", "inhibit", "the", "enzyme", "activity", "at", "a", "final", "concentration", "of", "800", "microM.", "These", "data", "suggest", "that", "the", "lavandulyl", "side", "chain", "and", "the", "position", "of", "the", "hydroxy", "group", "are", "important", "for", "high", "DGAT", "inhibitory", "activity", ".", "Compound", "1", "also", "inhibited", "de", "novo", "synthesis", "of", "triacylglycerol", "(", "TG", ")", "in", "Raji", "cells", "." ]	[ "GENE-Y", "CHEMICAL" ]
diacylglycerol acyltransferase, prenylflavonoids, prenylflavonoids, kurarinone, chalcone, kuraridin, kurarinol, kushenol H, kushenol K, diacylglycerol acyltransferase, DGAT, flavonoids, DGAT, prenylflavonoids, C3-OH, C3-OH, flavonoids, hesperetin, naringenin, quercetin, kaempferol, lavandulyl, hydroxy, DGAT, triacylglycerol, TG	30225_task2	Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O" ]	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.	[ "In", "vitro", "inhibition", "of", "diacylglycerol", "acyltransferase", "by", "prenylflavonoids", "from", "Sophora", "flavescens", ".", "\n", "Four", "prenylflavonoids", ",", "kurarinone", "(", "1", ")", ",", "a", "chalcone", "of", "1", ",", "kuraridin", "(", "2", ")", ",", "kurarinol", "(", "3", ")", ",", "kushenol", "H", "(", "4", ")", "and", "kushenol", "K", "(", "5", ")", "isolated", "from", "the", "roots", "of", "Sophora", "flavescens", "were", "investigated", "for", "their", "inhibitory", "effects", "on", "diacylglycerol", "acyltransferase", "(", "DGAT", ")", ".", "The", "flavonoids", "inhibited", "DGAT", "activity", "in", "a", "dose", "-", "dependent", "manner", "with", "IC50", "values", "of", "10.9", "microM", "(", "1", ")", ",", "9.8", "microM", "(", "2", ")", ",", "8.6", "microM", "(", "3", ")", ",", "142.0", "microM", "(", "4", ")", "and", "250", "microM", "(", "5", ")", ".", "The", "prenylflavonoids", "without", "C3-OH", "(", "1", ",", "2", ",", "3", ")", "showed", "stronger", "inhibition", "than", "those", "with", "C3-OH", "(", "4", ",", "5", ")", ".", "On", "the", "other", "hand", ",", "flavonoids", "without", "side", "chains", "(", "hesperetin", ",", "naringenin", ",", "quercetin", "and", "kaempferol", ")", "did", "not", "inhibit", "the", "enzyme", "activity", "at", "a", "final", "concentration", "of", "800", "microM.", "These", "data", "suggest", "that", "the", "lavandulyl", "side", "chain", "and", "the", "position", "of", "the", "hydroxy", "group", "are", "important", "for", "high", "DGAT", "inhibitory", "activity", ".", "Compound", "1", "also", "inhibited", "de", "novo", "synthesis", "of", "triacylglycerol", "(", "TG", ")", "in", "Raji", "cells", "." ]	[ "GENE-Y", "CHEMICAL" ]
Mitochondrial electron transfer chain complexes is a GENE-N, organochalcogens is a CHEMICAL	23103426_task0	Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL	[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]	Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.	[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Mitochondrial electron transfer chain complexes is a GENE-N, organochalcogens is a CHEMICAL	23103426_task1	Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please typing these entity words according to sentence: Mitochondrial electron transfer chain complexes, organochalcogens Options: GENE-N, CHEMICAL	[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]	Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.	[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Mitochondrial electron transfer chain complexes, organochalcogens	23103426_task2	Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]	Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.	[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
LEAP , TEACCH is a Intervention_Educational, non - model - specific special education programs is a Intervention_Educational, preschoolers is a Participant_Age, autism spectrum disorders is a Participant_Condition, LEAP and TEACCH is a Intervention_Educational, young children is a Participant_Age, high fidelity LEAP is a Intervention_Educational, 198 is a Participant_Sample-size	60280_task0	Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Participant_Age, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .	[ "Comparative", "efficacy", "of", "LEAP", ",", "TEACCH", "and", "non", "-", "model", "-", "specific", "special", "education", "programs", "for", "preschoolers", "with", "autism", "spectrum", "disorders", ".", "LEAP", "and", "TEACCH", "represent", "two", "comprehensive", "treatment", "models", "(", "CTMs", ")", "that", "have", "been", "widely", "used", "across", "several", "decades", "to", "educate", "young", "children", "with", "autism", "spectrum", "disorders", ".", "The", "purpose", "of", "this", "quasi", "-", "experimental", "study", "was", "to", "compare", "high", "fidelity", "LEAP", "(", "n", "=", "22", ")", "and", "TEACCH", "(", "n", "=", "25", ")", "classrooms", "to", "each", "other", "and", "a", "control", "condition", "(", "n", "=", "28", ")", ",", "in", "which", "teachers", "in", "high", "quality", "special", "education", "programs", "used", "non", "-", "model", "-", "specific", "practices", ".", "A", "total", "of", "198", "children", "were", "included", "in", "data", "analysis", ".", "Across", "conditions", ",", "children", "'", "s", "performances", "improved", "over", "time", ".", "This", "study", "raises", "issues", "of", "the", "replication", "of", "effects", "for", "CTMs", ",", "and", "whether", "having", "access", "to", "a", "high", "quality", "special", "education", "program", "is", "as", "beneficial", "as", "access", "to", "a", "specific", "CTM", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
LEAP , TEACCH is a Intervention_Educational, non - model - specific special education programs is a Intervention_Educational, preschoolers is a Participant_Age, autism spectrum disorders is a Participant_Condition, LEAP and TEACCH is a Intervention_Educational, young children is a Participant_Age, high fidelity LEAP is a Intervention_Educational, 198 is a Participant_Sample-size	60280_task1	Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please typing these entity words according to sentence: LEAP , TEACCH, non - model - specific special education programs, preschoolers, autism spectrum disorders, LEAP and TEACCH, young children, high fidelity LEAP, 198 Options: Intervention_Educational, Participant_Age, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .	[ "Comparative", "efficacy", "of", "LEAP", ",", "TEACCH", "and", "non", "-", "model", "-", "specific", "special", "education", "programs", "for", "preschoolers", "with", "autism", "spectrum", "disorders", ".", "LEAP", "and", "TEACCH", "represent", "two", "comprehensive", "treatment", "models", "(", "CTMs", ")", "that", "have", "been", "widely", "used", "across", "several", "decades", "to", "educate", "young", "children", "with", "autism", "spectrum", "disorders", ".", "The", "purpose", "of", "this", "quasi", "-", "experimental", "study", "was", "to", "compare", "high", "fidelity", "LEAP", "(", "n", "=", "22", ")", "and", "TEACCH", "(", "n", "=", "25", ")", "classrooms", "to", "each", "other", "and", "a", "control", "condition", "(", "n", "=", "28", ")", ",", "in", "which", "teachers", "in", "high", "quality", "special", "education", "programs", "used", "non", "-", "model", "-", "specific", "practices", ".", "A", "total", "of", "198", "children", "were", "included", "in", "data", "analysis", ".", "Across", "conditions", ",", "children", "'", "s", "performances", "improved", "over", "time", ".", "This", "study", "raises", "issues", "of", "the", "replication", "of", "effects", "for", "CTMs", ",", "and", "whether", "having", "access", "to", "a", "high", "quality", "special", "education", "program", "is", "as", "beneficial", "as", "access", "to", "a", "specific", "CTM", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
LEAP , TEACCH, non - model - specific special education programs, preschoolers, autism spectrum disorders, LEAP and TEACCH, young children, high fidelity LEAP, 198	60280_task2	Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .	[ "Comparative", "efficacy", "of", "LEAP", ",", "TEACCH", "and", "non", "-", "model", "-", "specific", "special", "education", "programs", "for", "preschoolers", "with", "autism", "spectrum", "disorders", ".", "LEAP", "and", "TEACCH", "represent", "two", "comprehensive", "treatment", "models", "(", "CTMs", ")", "that", "have", "been", "widely", "used", "across", "several", "decades", "to", "educate", "young", "children", "with", "autism", "spectrum", "disorders", ".", "The", "purpose", "of", "this", "quasi", "-", "experimental", "study", "was", "to", "compare", "high", "fidelity", "LEAP", "(", "n", "=", "22", ")", "and", "TEACCH", "(", "n", "=", "25", ")", "classrooms", "to", "each", "other", "and", "a", "control", "condition", "(", "n", "=", "28", ")", ",", "in", "which", "teachers", "in", "high", "quality", "special", "education", "programs", "used", "non", "-", "model", "-", "specific", "practices", ".", "A", "total", "of", "198", "children", "were", "included", "in", "data", "analysis", ".", "Across", "conditions", ",", "children", "'", "s", "performances", "improved", "over", "time", ".", "This", "study", "raises", "issues", "of", "the", "replication", "of", "effects", "for", "CTMs", ",", "and", "whether", "having", "access", "to", "a", "high", "quality", "special", "education", "program", "is", "as", "beneficial", "as", "access", "to", "a", "specific", "CTM", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
Patienten is an umlsterm, Gesichtes is an umlsterm, Halses is an umlsterm, Gastroenteritis is an umlsterm, Asthma bronchiale is an umlsterm, Eosinophilie is an umlsterm, Differentialblutbild is an umlsterm, Hautbiopsien is an umlsterm, Magen- is an umlsterm, Duodenalschleimhaut is an umlsterm, Gastroenteritis is an umlsterm, Eosinophilie is an umlsterm, Literatur is an umlsterm, Syndromen is an umlsterm, Gastroenteritis is an umlsterm, Angiooedem is an umlsterm, Eosinophilie is an umlsterm	DerHautarzt.80490566.ger.abstr_task0	Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .	[ "Wir", "beschreiben", "einen", "23jaehrigen", "Patienten", "mit", "rezidivierenden", "Angiooedemen", "des", "Gesichtes", "und", "des", "Halses", "und", "begleitender", "Gastroenteritis", ".", "Zusaetzlich", "bestanden", "ein", "Asthma", "bronchiale", "eine", "Polyposis", "nasi", "und", "eine", "Rhinoconjunctivitis", "allergica", ".", ",", "Neben", "einer", "Eosinophilie", "im", "Differentialblutbild", "fanden", "sich", "histologisch", "eosinophile", "Infiltrate", "sowohl", "in", "den", "Hautbiopsien", "als", "auch", "in", "der", "Oesophagus-", ",", "Magen-", "und", "Duodenalschleimhaut", ".", "Unter", "systemischer", "Kortikosteroidtherapie", "kam", "es", "zu", "einer", "kompletten", "Rueckbildung", "der", "Angiooedeme", ",", "der", "Gastroenteritis", "und", "der", "Eosinophilie", ".", "Das", "von", "uns", "vorgestellte", "Krankheitsbild", "zeigt", "deutliche", "Parallelen", "zu", "seltenen", "in", "der", "Literatur", "beschriebenen", "Syndromen", "(", "eosinophile", "Gastroenteritis", ",", "Samter", "-", "Syndrom", ",", "episodisches", "Angiooedem", "mit", "Eosinophilie", ")", ",", "ist", "aber", "u.", "W.", "nach", "in", "dieser", "Symptomenkonstellation", "bisher", "noch", "nicht", "bekannt", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Gesichtes is an umlsterm, Halses is an umlsterm, Gastroenteritis is an umlsterm, Asthma bronchiale is an umlsterm, Eosinophilie is an umlsterm, Differentialblutbild is an umlsterm, Hautbiopsien is an umlsterm, Magen- is an umlsterm, Duodenalschleimhaut is an umlsterm, Gastroenteritis is an umlsterm, Eosinophilie is an umlsterm, Literatur is an umlsterm, Syndromen is an umlsterm, Gastroenteritis is an umlsterm, Angiooedem is an umlsterm, Eosinophilie is an umlsterm	DerHautarzt.80490566.ger.abstr_task1	Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please typing these entity words according to sentence: Patienten, Gesichtes, Halses, Gastroenteritis, Asthma bronchiale, Eosinophilie, Differentialblutbild, Hautbiopsien, Magen-, Duodenalschleimhaut, Gastroenteritis, Eosinophilie, Literatur, Syndromen, Gastroenteritis, Angiooedem, Eosinophilie Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .	[ "Wir", "beschreiben", "einen", "23jaehrigen", "Patienten", "mit", "rezidivierenden", "Angiooedemen", "des", "Gesichtes", "und", "des", "Halses", "und", "begleitender", "Gastroenteritis", ".", "Zusaetzlich", "bestanden", "ein", "Asthma", "bronchiale", "eine", "Polyposis", "nasi", "und", "eine", "Rhinoconjunctivitis", "allergica", ".", ",", "Neben", "einer", "Eosinophilie", "im", "Differentialblutbild", "fanden", "sich", "histologisch", "eosinophile", "Infiltrate", "sowohl", "in", "den", "Hautbiopsien", "als", "auch", "in", "der", "Oesophagus-", ",", "Magen-", "und", "Duodenalschleimhaut", ".", "Unter", "systemischer", "Kortikosteroidtherapie", "kam", "es", "zu", "einer", "kompletten", "Rueckbildung", "der", "Angiooedeme", ",", "der", "Gastroenteritis", "und", "der", "Eosinophilie", ".", "Das", "von", "uns", "vorgestellte", "Krankheitsbild", "zeigt", "deutliche", "Parallelen", "zu", "seltenen", "in", "der", "Literatur", "beschriebenen", "Syndromen", "(", "eosinophile", "Gastroenteritis", ",", "Samter", "-", "Syndrom", ",", "episodisches", "Angiooedem", "mit", "Eosinophilie", ")", ",", "ist", "aber", "u.", "W.", "nach", "in", "dieser", "Symptomenkonstellation", "bisher", "noch", "nicht", "bekannt", "." ]	[ "umlsterm" ]
Patienten, Gesichtes, Halses, Gastroenteritis, Asthma bronchiale, Eosinophilie, Differentialblutbild, Hautbiopsien, Magen-, Duodenalschleimhaut, Gastroenteritis, Eosinophilie, Literatur, Syndromen, Gastroenteritis, Angiooedem, Eosinophilie	DerHautarzt.80490566.ger.abstr_task2	Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .	[ "Wir", "beschreiben", "einen", "23jaehrigen", "Patienten", "mit", "rezidivierenden", "Angiooedemen", "des", "Gesichtes", "und", "des", "Halses", "und", "begleitender", "Gastroenteritis", ".", "Zusaetzlich", "bestanden", "ein", "Asthma", "bronchiale", "eine", "Polyposis", "nasi", "und", "eine", "Rhinoconjunctivitis", "allergica", ".", ",", "Neben", "einer", "Eosinophilie", "im", "Differentialblutbild", "fanden", "sich", "histologisch", "eosinophile", "Infiltrate", "sowohl", "in", "den", "Hautbiopsien", "als", "auch", "in", "der", "Oesophagus-", ",", "Magen-", "und", "Duodenalschleimhaut", ".", "Unter", "systemischer", "Kortikosteroidtherapie", "kam", "es", "zu", "einer", "kompletten", "Rueckbildung", "der", "Angiooedeme", ",", "der", "Gastroenteritis", "und", "der", "Eosinophilie", ".", "Das", "von", "uns", "vorgestellte", "Krankheitsbild", "zeigt", "deutliche", "Parallelen", "zu", "seltenen", "in", "der", "Literatur", "beschriebenen", "Syndromen", "(", "eosinophile", "Gastroenteritis", ",", "Samter", "-", "Syndrom", ",", "episodisches", "Angiooedem", "mit", "Eosinophilie", ")", ",", "ist", "aber", "u.", "W.", "nach", "in", "dieser", "Symptomenkonstellation", "bisher", "noch", "nicht", "bekannt", "." ]	[ "umlsterm" ]

clozapine, 5-hydroxytryptamine1C, 5-hydroxytryptamine2

1403790_task2

Sentence: The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O" ]

The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors.

[ "The", "discriminative", "stimulus", "effects", "of", "clozapine", "in", "pigeons", ":", "involvement", "of", "5-hydroxytryptamine1C", "and", "5-hydroxytryptamine2", "receptors", "." ]

[ "CHEMICAL", "GENE-N" ]

chemokine ( C - C motif ) ligand 2 is a GENE-Y, monocyte chemotactic protein-1 is a GENE-Y, cisplatin is a CHEMICAL

23291264_task0

Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]

Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.

[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

chemokine ( C - C motif ) ligand 2 is a GENE-Y, monocyte chemotactic protein-1 is a GENE-Y, cisplatin is a CHEMICAL

23291264_task1

Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please typing these entity words according to sentence: chemokine ( C - C motif ) ligand 2, monocyte chemotactic protein-1, cisplatin Options: GENE-Y, CHEMICAL

[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]

Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.

[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

chemokine ( C - C motif ) ligand 2, monocyte chemotactic protein-1, cisplatin

23291264_task2

Sentence: Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Instructions: please extract entity words from the input sentence

[ "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O" ]

Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.

[ "Urinary", "chemokine", "(", "C", "-", "C", "motif", ")", "ligand", "2", "(", "monocyte", "chemotactic", "protein-1", ")", "as", "a", "tubular", "injury", "marker", "for", "early", "detection", "of", "cisplatin", "-", "induced", "nephrotoxicity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

actin is a Gene/protein/RNA, actin is a Individual_protein, actin depolymerizing factor is a Individual_protein, ADF is a Individual_protein, gelsolin is a Individual_protein, profilin is a Individual_protein, thymosin beta4 is a Individual_protein, Tbeta4 is a Individual_protein

196_task0

Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]

Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).

[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

actin is a Gene/protein/RNA, actin is a Individual_protein, actin depolymerizing factor is a Individual_protein, ADF is a Individual_protein, gelsolin is a Individual_protein, profilin is a Individual_protein, thymosin beta4 is a Individual_protein, Tbeta4 is a Individual_protein

196_task1

Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please typing these entity words according to sentence: actin, actin, actin depolymerizing factor, ADF, gelsolin, profilin, thymosin beta4, Tbeta4 Options: Gene/protein/RNA, Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]

Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).

[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

actin, actin, actin depolymerizing factor, ADF, gelsolin, profilin, thymosin beta4, Tbeta4

196_task2

Sentence: Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "B-Individual_protein", "O", "O" ]

Chick embryo fibroblasts contain about 75-100 microM unpolymerized actin and at least four proteins which can bind actin monomers, actin depolymerizing factor (ADF), gelsolin, profilin, and thymosin beta4 (Tbeta4).

[ "Chick", "embryo", "fibroblasts", "contain", "about", "75", "-", "100", "microM", "unpolymerized", "actin", "and", "at", "least", "four", "proteins", "which", "can", "bind", "actin", "monomers", ",", "actin", "depolymerizing", "factor", "(", "ADF", ")", ",", "gelsolin", ",", "profilin", ",", "and", "thymosin", "beta4", "(", "Tbeta4", ")", "." ]

[ "Individual_protein", "Gene/protein/RNA" ]

RAD54 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA

682_task0

Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA

[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.

[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]

[ "Gene/protein/RNA" ]

RAD54 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA

682_task1

Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please typing these entity words according to sentence: RAD54, RAD51 Options: Gene/protein/RNA

[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.

[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]

[ "Gene/protein/RNA" ]

RAD54, RAD51

682_task2

Sentence: The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. Instructions: please extract entity words from the input sentence

[ "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae.

[ "The", "RAD54", "and", "RAD51", "genes", "are", "involved", "in", "genetic", "recombination", "and", "double", "-", "strand", "break", "repair", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "." ]

[ "Gene/protein/RNA" ]

complication is an umlsterm, time is an umlsterm, catheter is an umlsterm, patient is an umlsterm, complication is an umlsterm, dislocation is an umlsterm, catheter is an umlsterm, Hydromediastinum is an umlsterm, hydrothorax is an umlsterm, diagnosis is an umlsterm, catheter is an umlsterm, cause is an umlsterm, complication is an umlsterm, symptoms is an umlsterm, mediastinitis is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, patient is an umlsterm, treatment is an umlsterm, malformation is an umlsterm

DerAnaesthesist.90480900.eng.abstr_task0

Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .

[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]

[ "umlsterm" ]

complication is an umlsterm, time is an umlsterm, catheter is an umlsterm, patient is an umlsterm, complication is an umlsterm, dislocation is an umlsterm, catheter is an umlsterm, Hydromediastinum is an umlsterm, hydrothorax is an umlsterm, diagnosis is an umlsterm, catheter is an umlsterm, cause is an umlsterm, complication is an umlsterm, symptoms is an umlsterm, mediastinitis is an umlsterm, antibiotic is an umlsterm, therapy is an umlsterm, patient is an umlsterm, treatment is an umlsterm, malformation is an umlsterm

DerAnaesthesist.90480900.eng.abstr_task1

Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please typing these entity words according to sentence: complication, time, catheter, patient, complication, dislocation, catheter, Hydromediastinum, hydrothorax, diagnosis, catheter, cause, complication, symptoms, mediastinitis, antibiotic, therapy, patient, treatment, malformation Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .

[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]

[ "umlsterm" ]

complication, time, catheter, patient, complication, dislocation, catheter, Hydromediastinum, hydrothorax, diagnosis, catheter, cause, complication, symptoms, mediastinitis, antibiotic, therapy, patient, treatment, malformation

DerAnaesthesist.90480900.eng.abstr_task2

Sentence: We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

We report a complication during the insertion time of a central venous catheter in a patient with intracerebral bleeding . This complication was caused by an inadvertent dislocation of a subclavian catheter . Hydromediastinum and bilateral hydrothorax developed . There was a clear diagnosis followed by removal of the central venous catheter after radiological investigations could explain the cause of the complication and the clinical symptoms . In the course of events mediastinitis was diagnosed . The clinical condition improved under antibiotic therapy . The patient could be transferred to another clinical unit for endovascular treatment of an arterio-venous cerebral malformation .

[ "We", "report", "a", "complication", "during", "the", "insertion", "time", "of", "a", "central", "venous", "catheter", "in", "a", "patient", "with", "intracerebral", "bleeding", ".", "This", "complication", "was", "caused", "by", "an", "inadvertent", "dislocation", "of", "a", "subclavian", "catheter", ".", "Hydromediastinum", "and", "bilateral", "hydrothorax", "developed", ".", "There", "was", "a", "clear", "diagnosis", "followed", "by", "removal", "of", "the", "central", "venous", "catheter", "after", "radiological", "investigations", "could", "explain", "the", "cause", "of", "the", "complication", "and", "the", "clinical", "symptoms", ".", "In", "the", "course", "of", "events", "mediastinitis", "was", "diagnosed", ".", "The", "clinical", "condition", "improved", "under", "antibiotic", "therapy", ".", "The", "patient", "could", "be", "transferred", "to", "another", "clinical", "unit", "for", "endovascular", "treatment", "of", "an", "arterio", "-", "venous", "cerebral", "malformation", "." ]

[ "umlsterm" ]

Objective is an umlsterm, joint is an umlsterm

ZfuerRheumatologie.0059ii90.eng.abstr_task0

Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .

[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]

[ "umlsterm" ]

Objective is an umlsterm, joint is an umlsterm

ZfuerRheumatologie.0059ii90.eng.abstr_task1

Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please typing these entity words according to sentence: Objective, joint Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .

[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]

[ "umlsterm" ]

Objective, joint

ZfuerRheumatologie.0059ii90.eng.abstr_task2

Sentence: Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Objective : To test if continuous LDPT decreases radiographically detectable joint destruction in early RA .

[ "Objective", ":", "To", "test", "if", "continuous", "LDPT", "decreases", "radiographically", "detectable", "joint", "destruction", "in", "early", "RA", "." ]

[ "umlsterm" ]

wachsende is an umlsterm, alter Menschen is an umlsterm, Element is an umlsterm, Euthanasiedebatte is an umlsterm

ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task0

Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .

[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]

[ "umlsterm" ]

wachsende is an umlsterm, alter Menschen is an umlsterm, Element is an umlsterm, Euthanasiedebatte is an umlsterm

ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task1

Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please typing these entity words according to sentence: wachsende, alter Menschen, Element, Euthanasiedebatte Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .

[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]

[ "umlsterm" ]

wachsende, alter Menschen, Element, Euthanasiedebatte

ZfuerGerontologie+Geriatrie.90320273.ger.abstr_task2

Sentence: Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Explosionsartig wachsende medizinische und soziale Versorgungsangebote als Reaktion auf die zunehmende Zahl multimorbider und behinderter alter Menschen einerseits , die unuebersehbar gewordene oekonomische Bedeutung der Gesundheitsindustrie zum anderen und - als drittes Element - die neue " oeffentliche Euthanasiedebatte " werden meist als unabhaengige Variable in der ethischen Diskussion behandelt und sind zugleich heftig umstritten .

[ "Explosionsartig", "wachsende", "medizinische", "und", "soziale", "Versorgungsangebote", "als", "Reaktion", "auf", "die", "zunehmende", "Zahl", "multimorbider", "und", "behinderter", "alter", "Menschen", "einerseits", ",", "die", "unuebersehbar", "gewordene", "oekonomische", "Bedeutung", "der", "Gesundheitsindustrie", "zum", "anderen", "und", "-", "als", "drittes", "Element", "-", "die", "neue", "\"", "oeffentliche", "Euthanasiedebatte", "\"", "werden", "meist", "als", "unabhaengige", "Variable", "in", "der", "ethischen", "Diskussion", "behandelt", "und", "sind", "zugleich", "heftig", "umstritten", "." ]

[ "umlsterm" ]

4-phenylpiperidines is a CHEMICAL, 4-phenylpiperazines is a CHEMICAL

23353756_task0

Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]

Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.

[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]

[ "CHEMICAL", "GENE-Y" ]

4-phenylpiperidines is a CHEMICAL, 4-phenylpiperazines is a CHEMICAL

23353756_task1

Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please typing these entity words according to sentence: 4-phenylpiperidines, 4-phenylpiperazines Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]

Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.

[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]

[ "CHEMICAL", "GENE-Y" ]

4-phenylpiperidines, 4-phenylpiperazines

23353756_task2

Sentence: Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]

Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.

[ "Synthesis", ",", "pharmacological", "evaluation", "and", "QSAR", "modeling", "of", "mono", "-", "substituted", "4-phenylpiperidines", "and", "4-phenylpiperazines", "." ]

[ "CHEMICAL", "GENE-Y" ]

other cancers is a Condition, at the same time is a Temporal, other cancers is a Condition, except is a Negation, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus is a Scope, active is a Temporal, infections is a Condition, not is a Negation, suitable for chemotherapy is a Qualifier, severe is a Qualifier, non - cancerous diseases is a Condition, neoadjuvant hormone therapy is a Procedure, bilateral breast cancers is a Condition, DCIS is a Condition, metastatic breast cancers is a Condition, anti - cancer therapies is a Procedure, attending other clinical trials is a Observation, pregnant is a Condition, lactational is a Condition, refuse to practice is a Negation, contraception is a Procedure, during the whole trial is a Temporal, allergic history or contraindication is a Scope, tamoxifen is a Drug

NCT02062489_exc_task0

Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Observation, Procedure, Negation, Scope, Drug

[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]

The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.

[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]

[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]

other cancers is a Condition, at the same time is a Temporal, other cancers is a Condition, except is a Negation, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus is a Scope, active is a Temporal, infections is a Condition, not is a Negation, suitable for chemotherapy is a Qualifier, severe is a Qualifier, non - cancerous diseases is a Condition, neoadjuvant hormone therapy is a Procedure, bilateral breast cancers is a Condition, DCIS is a Condition, metastatic breast cancers is a Condition, anti - cancer therapies is a Procedure, attending other clinical trials is a Observation, pregnant is a Condition, lactational is a Condition, refuse to practice is a Negation, contraception is a Procedure, during the whole trial is a Temporal, allergic history or contraindication is a Scope, tamoxifen is a Drug

NCT02062489_exc_task1

Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please typing these entity words according to sentence: other cancers, at the same time, other cancers, except, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus, active, infections, not, suitable for chemotherapy, severe, non - cancerous diseases, neoadjuvant hormone therapy, bilateral breast cancers, DCIS, metastatic breast cancers, anti - cancer therapies, attending other clinical trials, pregnant, lactational, refuse to practice, contraception, during the whole trial, allergic history or contraindication, tamoxifen Options: Temporal, Condition, Qualifier, Observation, Procedure, Negation, Scope, Drug

[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]

The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.

[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]

[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]

other cancers, at the same time, other cancers, except, controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus, active, infections, not, suitable for chemotherapy, severe, non - cancerous diseases, neoadjuvant hormone therapy, bilateral breast cancers, DCIS, metastatic breast cancers, anti - cancer therapies, attending other clinical trials, pregnant, lactational, refuse to practice, contraception, during the whole trial, allergic history or contraindication, tamoxifen

NCT02062489_exc_task2

Sentence: The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Negation", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Temporal", "B-Condition", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O" ]

The patients have other cancers at the same time or have the history of other cancers except controlled skin basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of cervix uterus; The patients have active infections that were not suitable for chemotherapy; The patients have severe non-cancerous diseases. The patients have history of neoadjuvant hormone therapy. The patients have bilateral breast cancers or DCIS or metastatic breast cancers. The patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials. The patients are pregnant or lactational, or they refuse to practice contraception during the whole trial. The patients are in some special conditions that they can't understand the written informed consent, such as they are demented or hawkish. The patients have allergic history or contraindication of tamoxifen.

[ "The", "patients", "have", "other", "cancers", "at", "the", "same", "time", "or", "have", "the", "history", "of", "other", "cancers", "except", "controlled", "skin", "basal", "cell", "carcinoma", "or", "skin", "squamous", "cell", "carcinoma", "or", "carcinoma", "in", "situ", "of", "cervix", "uterus", ";", "\n", "The", "patients", "have", "active", "infections", "that", "were", "not", "suitable", "for", "chemotherapy", ";", "\n", "The", "patients", "have", "severe", "non", "-", "cancerous", "diseases", ".", "\n", "The", "patients", "have", "history", "of", "neoadjuvant", "hormone", "therapy", ".", "\n", "The", "patients", "have", "bilateral", "breast", "cancers", "or", "DCIS", "or", "metastatic", "breast", "cancers", ".", "\n", "The", "patients", "are", "undergoing", "current", "administration", "of", "anti", "-", "cancer", "therapies", ",", "or", "are", "attending", "other", "clinical", "trials", ".", "\n", "The", "patients", "are", "pregnant", "or", "lactational", ",", "or", "they", "refuse", "to", "practice", "contraception", "during", "the", "whole", "trial", ".", "\n", "The", "patients", "are", "in", "some", "special", "conditions", "that", "they", "can't", "understand", "the", "written", "informed", "consent", ",", "such", "as", "they", "are", "demented", "or", "hawkish", ".", "\n", "The", "patients", "have", "allergic", "history", "or", "contraindication", "of", "tamoxifen", ".", "\n" ]

[ "Scope", "Condition", "Observation", "Procedure", "Qualifier", "Temporal", "Negation", "Drug" ]

Abstract is an umlsterm, tissue culture is an umlsterm, method is an umlsterm, technique is an umlsterm, cell is an umlsterm, metabolic disorders is an umlsterm, Standard is an umlsterm, methods is an umlsterm, in vitro is an umlsterm, culture is an umlsterm, tumor is an umlsterm, cultures is an umlsterm, organ cultures is an umlsterm, ation is an umlsterm, tissue is an umlsterm, tissue culture is an umlsterm, cell culture is an umlsterm, genetic material is an umlsterm, cells is an umlsterm

DerPathologe.40150141.eng.abstr_task0

Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .

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DerPathologe.40150141.eng.abstr_task1

Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please typing these entity words according to sentence: Abstract, tissue culture, method, technique, cell, metabolic disorders, Standard, methods, in vitro, culture, tumor, cultures, organ cultures, ation, tissue, tissue culture, cell culture, genetic material, cells Options: umlsterm

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Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .

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DerPathologe.40150141.eng.abstr_task2

Sentence: Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described . Instructions: please extract entity words from the input sentence

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Abstract . This article describes how tissue culture has developed from an observing method to a powerful analytical technique for oncology and for pathological cell changes such as metabolic disorders and degenerative diseas es . Standard terms are defined and basic methods are explained . Different models of in vitro culture - monolayer , three-dimensional tumor cultures , and organ cultures - are critically reviewed in respect of their significance for the interpret ation of in vivo tissue . Two important recent extensions of tissue culture , serum-free cell culture and the introduction of genetic material into cells , are described .

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ZfuerKardiologie.8087s074.ger.abstr_task0

Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .

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[ "umlsterm" ]

Blutfluss is an umlsterm, Vasodilatation is an umlsterm, Methode is an umlsterm, Diagnostik is an umlsterm, Techniken is an umlsterm, Thermodilution is an umlsterm, Sauerstoffsaettigung is an umlsterm, Argon - Fremdgas - Methode is an umlsterm, Analyse is an umlsterm, Mikrozirkulation is an umlsterm, Therapie is an umlsterm, Methoden is an umlsterm, Densitometrie is an umlsterm, Druckdraht is an umlsterm, Methode is an umlsterm, Koronargefaess is an umlsterm, Koronarstenose is an umlsterm, Beurteilung is an umlsterm, Methode is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Myokardfunktion is an umlsterm, Patienten is an umlsterm

ZfuerKardiologie.8087s074.ger.abstr_task1

Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . Instructions: please typing these entity words according to sentence: Blutfluss, Vasodilatation, Methode, Diagnostik, Techniken, Thermodilution, Sauerstoffsaettigung, Argon - Fremdgas - Methode, Analyse, Mikrozirkulation, Therapie, Methoden, Densitometrie, Druckdraht, Methode, Koronargefaess, Koronarstenose, Beurteilung, Methode, Methoden, Patienten, Diagnostik, Myokardfunktion, Patienten Options: umlsterm

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Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .

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[ "umlsterm" ]

Blutfluss, Vasodilatation, Methode, Diagnostik, Techniken, Thermodilution, Sauerstoffsaettigung, Argon - Fremdgas - Methode, Analyse, Mikrozirkulation, Therapie, Methoden, Densitometrie, Druckdraht, Methode, Koronargefaess, Koronarstenose, Beurteilung, Methode, Methoden, Patienten, Diagnostik, Myokardfunktion, Patienten

ZfuerKardiologie.8087s074.ger.abstr_task2

Sentence: Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss . Instructions: please extract entity words from the input sentence

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Die Bestimmung der koronaren Flussreserve , dem Verhaeltnis aus koronarem Blutfluss unter maximaler Vasodilatation und in Ruhe , ist ergaenzend zur rein bildmorphologischen , angiographischen Darstellung eine funktionelle Methode zur Diagnostik der koronaren Strombahn . Die derzeit zur Verfuegung stehenden Untersuchungsmethoden und deren verschiedenen Techniken werden besonders unter dem Aspekt der klinischen Einsatzmoeglichkeiten und der spezifischen Relevanz bei koronarer Makro- und Mikroangiopathie dargestellt . 1. Koronarsinustechniken , wie die Thermodilution oder die Messung der Sauerstoffsaettigung , sind aufgrund einer grossen Streubreite nur als semiquantitativ anzusehen . Die Argon-Fremdgas-Methode kann durch die quantitative Analyse des absoluten Koronarflusses Stoerungen der koronaren Mikrozirkulation funktionell untersuchen und laesst Moeglichkeiten zu Verlaufskontrollen unter entsprechender Therapie . 2. Von den angiographischen Methoden ist die TIMI-Frame-Count-Methode fuer die Bestimmung der koronaren Reserve ungeeignet und die Densitometrie kann nur an einem hochselektionierten Kollektiv eingeschraenkt Aussagen zur Funktion der koronaren Strombahn ermoeglichen . 3. Als intrakoronare Untersuchungsmethode ist neben dem technisch noch nicht ausgereiften Druckdraht besonders der intrakoronare Doppler eine Methode zur Messung der , jedoch regional auf das jeweilige Koronargefaess begrenzten , koronaren Flussreserve . Sie eignet sich vor allem zur Bestimmung der funktionellen Relevanz einer grenzwertigen Koronarstenose und zur Beurteilung des Erfolges nach einer koronaren Intervention . Es gibt keine einheitliche Methode zur Bestimmung der Koronarreserve , sondern jede dieser Methoden sollte mit ihren spezifischen Vor- und Nachteilen bei den entsprechenden Fragestellungen fuer den jeweiligen Patienten angewendet werden , um eine funktionelle Diagnostik zu ermoeglichen , die jedoch nicht isoliert , sondern immer in Bezug zur Myokardfunktion und klinischen Symptomatik des Patienten gesetzt werden muss .

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[ "umlsterm" ]

ATP is a chemical, PKM is a protein, lysine is an amino-acid, tryptophan is an amino-acid, K221W is a mutation, Raf-1 is a protein

1.0alpha7.train.791_task0

Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: amino-acid, chemical, mutation, protein

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Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).

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[ "amino-acid", "mutation", "protein", "chemical" ]

ATP is a chemical, PKM is a protein, lysine is an amino-acid, tryptophan is an amino-acid, K221W is a mutation, Raf-1 is a protein

1.0alpha7.train.791_task1

Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please typing these entity words according to sentence: ATP, PKM, lysine, tryptophan, K221W, Raf-1 Options: amino-acid, chemical, mutation, protein

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Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).

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[ "amino-acid", "mutation", "protein", "chemical" ]

ATP, PKM, lysine, tryptophan, K221W, Raf-1

1.0alpha7.train.791_task2

Sentence: Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41). Instructions: please extract entity words from the input sentence

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Within the ATP binding site of PKM , lysine 221 was changed to tryptophan (K221W) corresponding to a mutation in Raf-1 that abolished its kinase activity ( 41).

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[ "amino-acid", "mutation", "protein", "chemical" ]

Verletzungen is an umlsterm, unteren Hohlvene is an umlsterm, Komplikation is an umlsterm, Fallbericht is an umlsterm, Dissektion is an umlsterm, Beckenvenenthrombose is an umlsterm, Komplikation is an umlsterm

DerRadiologe.80380434.ger.abstr_task0

Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .

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[ "umlsterm" ]

Verletzungen is an umlsterm, unteren Hohlvene is an umlsterm, Komplikation is an umlsterm, Fallbericht is an umlsterm, Dissektion is an umlsterm, Beckenvenenthrombose is an umlsterm, Komplikation is an umlsterm

DerRadiologe.80380434.ger.abstr_task1

Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please typing these entity words according to sentence: Verletzungen, unteren Hohlvene, Komplikation, Fallbericht, Dissektion, Beckenvenenthrombose, Komplikation Options: umlsterm

[ "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .

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[ "umlsterm" ]

Verletzungen, unteren Hohlvene, Komplikation, Fallbericht, Dissektion, Beckenvenenthrombose, Komplikation

DerRadiologe.80380434.ger.abstr_task2

Sentence: Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben . Instructions: please extract entity words from the input sentence

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Verletzungen der unteren Hohlvene sind eine seltene Komplikation gefaesschirurgischer Eingriffe . In einem Fallbericht werden die Dissektion und Perforation der V. cava inferior durch ein Fogarty-Ballonmanoever bei postoperativer Beckenvenenthrombose und der computertomo- sowie phlebographische Nachweis dieser Komplikation beschrieben .

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[ "umlsterm" ]

Tumoren is an umlsterm, Schaedelbasis is an umlsterm, Hirn- is an umlsterm, Gesichtsschaedel is an umlsterm, Behandlung is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Rezidiveingriffen is an umlsterm, Tumorexstirpation is an umlsterm, Lungenembolie is an umlsterm, neurologische Defizite is an umlsterm, Patienten is an umlsterm, Postoperative Komplikationen is an umlsterm, Tumorinvasion is an umlsterm, Operationstechniken is an umlsterm, Tumoranteile is an umlsterm, Tumorexstirpation is an umlsterm, Morbiditaet is an umlsterm, Knochens is an umlsterm, postoperative Komplikationen is an umlsterm, Behandlungsergebnis is an umlsterm

MundKieferGesichtschirurgie.8002s058.ger.abstr_task0

Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .

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[ "umlsterm" ]

Tumoren is an umlsterm, Schaedelbasis is an umlsterm, Hirn- is an umlsterm, Gesichtsschaedel is an umlsterm, Behandlung is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Rezidiveingriffen is an umlsterm, Tumorexstirpation is an umlsterm, Lungenembolie is an umlsterm, neurologische Defizite is an umlsterm, Patienten is an umlsterm, Postoperative Komplikationen is an umlsterm, Tumorinvasion is an umlsterm, Operationstechniken is an umlsterm, Tumoranteile is an umlsterm, Tumorexstirpation is an umlsterm, Morbiditaet is an umlsterm, Knochens is an umlsterm, postoperative Komplikationen is an umlsterm, Behandlungsergebnis is an umlsterm

MundKieferGesichtschirurgie.8002s058.ger.abstr_task1

Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please typing these entity words according to sentence: Tumoren, Schaedelbasis, Hirn-, Gesichtsschaedel, Behandlung, Komplikationen, Patienten, Patienten, Rezidiveingriffen, Tumorexstirpation, Lungenembolie, neurologische Defizite, Patienten, Postoperative Komplikationen, Tumorinvasion, Operationstechniken, Tumoranteile, Tumorexstirpation, Morbiditaet, Knochens, postoperative Komplikationen, Behandlungsergebnis Options: umlsterm

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Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .

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[ "umlsterm" ]

Tumoren, Schaedelbasis, Hirn-, Gesichtsschaedel, Behandlung, Komplikationen, Patienten, Patienten, Rezidiveingriffen, Tumorexstirpation, Lungenembolie, neurologische Defizite, Patienten, Postoperative Komplikationen, Tumorinvasion, Operationstechniken, Tumoranteile, Tumorexstirpation, Morbiditaet, Knochens, postoperative Komplikationen, Behandlungsergebnis

MundKieferGesichtschirurgie.8002s058.ger.abstr_task2

Sentence: Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen . Instructions: please extract entity words from the input sentence

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Tumoren der frontalen Schaedelbasis entwickeln sich im Grenzgebiet von Hirn- und Gesichtsschaedel haeufig mit einer Ausbreitung nach intra- und extrakranial . Bei der operativen Behandlung wird diesen anatomischen Gegebenheiten durch kombinierte kraniofaziale Zugangswege Rechnung getragen , die von einem interdisziplinaeren Operationsteam durchgefuehrt werden . Um die Effektivitaet und Komplikationen dieses Behandlungskonzepts zu ueberpruefen , wurden die Daten von 58 Patienten aus den letzten 10 Jahren zusammengestellt . Bei diesen Patienten wurden mit 2 Rezidiveingriffen 60 Operationen durchgefuehrt . Bei 38 Eingriffen gelang eine vollstaendige Tumorexstirpation . Durch eine Lungenembolie ereignete sich ein postoperativer Todesfall . Funktionell relevante neurologische Defizite traten bei 3 Patienten auf . Postoperative Komplikationen und funktionelle Beeintraechtigungen wurden v. a. durch eine intradurale Tumorinvasion verursacht . Mit der Anwendung mikrochirurgischer Operationstechniken bei der Resektion der intraduralen Tumoranteile laesst sich meist eine radikale Tumorexstirpation bei akzeptabler Morbiditaet erreichen . Rekonstruktive Massnahmen bei Defekten im Bereich der Dura und des Knochens tragen entscheidend dazu bei , postoperative Komplikationen zu vermeiden und ein zufriedenstellendes kosmetisches Behandlungsergebnis zu erzielen .

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[ "umlsterm" ]

interleukin 2 is a Protein, interleukin 2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, GalNAc is a Entity, Gal(beta 1 - 3)GalNAc is a Entity, Thr is a Entity, IL-2 is a Protein, beta - galactoside alpha-2,3-sialyltransferase is a Protein, IL-2 is a Protein, interferon - beta is a Protein

552_task0

Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.

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[ "Protein", "Entity" ]

interleukin 2 is a Protein, interleukin 2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, IL-2 is a Protein, GalNAc is a Entity, Gal(beta 1 - 3)GalNAc is a Entity, Thr is a Entity, IL-2 is a Protein, beta - galactoside alpha-2,3-sialyltransferase is a Protein, IL-2 is a Protein, interferon - beta is a Protein

552_task1

Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please typing these entity words according to sentence: interleukin 2, interleukin 2, IL-2, IL-2, IL-2, IL-2, GalNAc, Gal(beta 1 - 3)GalNAc, Thr, IL-2, beta - galactoside alpha-2,3-sialyltransferase, IL-2, interferon - beta Options: Entity, Protein

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Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.

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[ "Protein", "Entity" ]

interleukin 2, interleukin 2, IL-2, IL-2, IL-2, IL-2, GalNAc, Gal(beta 1 - 3)GalNAc, Thr, IL-2, beta - galactoside alpha-2,3-sialyltransferase, IL-2, interferon - beta

552_task2

Sentence: Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs. Instructions: please extract entity words from the input sentence

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Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications. Human interleukin 2 (IL-2) and human IL-2 mutant proteins, with artificially introduced N-glycosylation or O-glycosylation sites, have been expressed in a lepidopteran cell line (Sf21, Spodoptera frugiperda) using recombinant baculovirus vectors. Only approximately 25% of the total recombinant IL-2 protein synthesized by Sf21 cells was secreted into the culture medium. Significant N-terminal truncations were detected in the secreted polypeptides (up to 85% of the molecules). Alanine and proline were absent in the major truncated forms; the first 3-5 amino acids were also absent in a small proportion of the purified proteins. The introduction of potential artificial O-glycosylation peptide sequences (..GGKAPTPPPK..), to the C-terminus or between positions 80 and 81 of the IL-2 polypeptide chain, resulted in the secretion of unglycosylated and O-glycosylated variant forms. Fast atom bombardment mass spectrometry, compositional analysis and methylation analysis, of the tryptic glycopeptide APTPPPK, revealed the presence of either GalNAc or the disaccharide Gal(beta 1-3)GalNAc as the only carbohydrate constituents attached exclusively to Thr in this peptide, in a specific ratio for each individual IL-2 mutant protein. The Gal(beta 1-3)GalNAc protein forms could be partially altered in vitro to mammalian-type glycoforms by porcine liver beta-galactoside alpha-2,3-sialyltransferase in the presence of CMP-N-acetylneuraminic acid. An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins. No evidence was obtained for the presence of secreted proteins with complex oligosaccharide chains, irrespective of the cell-culture conditions used or the harvesting time, for infected cells with recombinant baculovirus constructs.

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[ "Protein", "Entity" ]

patients is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, traumatic rupture is an umlsterm, vaccination is an umlsterm, patient is an umlsterm, health is an umlsterm, patients is an umlsterm, therapy - resistant is an umlsterm, sepsis is an umlsterm, Streptococcus pneumoniae is an umlsterm, blood is an umlsterm, culture is an umlsterm, Autopsy is an umlsterm, findings is an umlsterm, syndrome is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, diagnosis is an umlsterm, syndrome is an umlsterm, sepsis is an umlsterm

DerPathologe.70180257.eng.abstr_task0

Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .

[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]

[ "umlsterm" ]

patients is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, traumatic rupture is an umlsterm, vaccination is an umlsterm, patient is an umlsterm, health is an umlsterm, patients is an umlsterm, therapy - resistant is an umlsterm, sepsis is an umlsterm, Streptococcus pneumoniae is an umlsterm, blood is an umlsterm, culture is an umlsterm, Autopsy is an umlsterm, findings is an umlsterm, syndrome is an umlsterm, history is an umlsterm, splenectomy is an umlsterm, diagnosis is an umlsterm, syndrome is an umlsterm, sepsis is an umlsterm

DerPathologe.70180257.eng.abstr_task1

Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please typing these entity words according to sentence: patients, history, splenectomy, traumatic rupture, vaccination, patient, health, patients, therapy - resistant, sepsis, Streptococcus pneumoniae, blood, culture, Autopsy, findings, syndrome, history, splenectomy, diagnosis, syndrome, sepsis Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .

[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]

[ "umlsterm" ]

patients, history, splenectomy, traumatic rupture, vaccination, patient, health, patients, therapy - resistant, sepsis, Streptococcus pneumoniae, blood, culture, Autopsy, findings, syndrome, history, splenectomy, diagnosis, syndrome, sepsis

DerPathologe.70180257.eng.abstr_task2

Sentence: A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further .

[ "A", "report", "is", "given", "of", "two", "patients", "with", "a", "history", "of", "splenectomy", "many", "years", "previously", "due", "to", "traumatic", "rupture", ".", "No", "vaccination", "was", "given", "to", "either", "patient", ".", "From", "a", "state", "of", "good", "health", ",", "both", "patients", "developed", "fulminant", ",", "therapy", "-", "resistant", "sepsis", "with", "proof", "of", "Streptococcus", "pneumoniae", "in", "the", "blood", "culture", ".", "Autopsy", "findings", "were", "similar", "to", "Waterhouse", "-", "Friderichsen-", "syndrome", ".", "In", "conjunction", "with", "the", "history", "of", "splenectomy", ",", "the", "final", "pathological", "diagnosis", "was", "a", "so-", "called", "OPSI", "syndrome", ".", "This", "postsplenectomy", "sepsis", "is", "discussed", "further", "." ]

[ "umlsterm" ]

villin is a Individual_protein, fimbrin is a Individual_protein, actin is a Individual_protein, calmodulin is a Individual_protein

735_task0

Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]

The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).

[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]

[ "Individual_protein" ]

villin is a Individual_protein, fimbrin is a Individual_protein, actin is a Individual_protein, calmodulin is a Individual_protein

735_task1

Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please typing these entity words according to sentence: villin, fimbrin, actin, calmodulin Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]

The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).

[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]

[ "Individual_protein" ]

villin, fimbrin, actin, calmodulin

735_task2

Sentence: The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O" ]

The microvillus cytoskeleton, isolated from chicken intestinal epithelial cell brush borders, is known to contain five major protein components, the 110,000-dalton polypeptide, villin (95,000 daltons), fimbrin (68,000 daltons), actin (43,000 daltons), and calmodulin (17,000 daltons).

[ "The", "microvillus", "cytoskeleton", ",", "isolated", "from", "chicken", "intestinal", "epithelial", "cell", "brush", "borders", ",", "is", "known", "to", "contain", "five", "major", "protein", "components", ",", "the", "110,000-dalton", "polypeptide", ",", "villin", "(", "95,000", "daltons", ")", ",", "fimbrin", "(", "68,000", "daltons", ")", ",", "actin", "(", "43,000", "daltons", ")", ",", "and", "calmodulin", "(", "17,000", "daltons", ")", "." ]

[ "Individual_protein" ]

pentoxifylline is a CHEMICAL

16426349_task0

Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.

[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]

[ "GENE-Y", "CHEMICAL" ]

pentoxifylline is a CHEMICAL

16426349_task1

Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please typing these entity words according to sentence: pentoxifylline Options: CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.

[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]

[ "GENE-Y", "CHEMICAL" ]

pentoxifylline

16426349_task2

Sentence: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.

[ "The", "effects", "of", "pentoxifylline", "on", "the", "myocardial", "inflammation", "and", "ischemia", "-", "reperfusion", "injury", "during", "cardiopulmonary", "bypass", "." ]

[ "GENE-Y", "CHEMICAL" ]

propionate is a compound, fumarate is a compound, hydrogenase is a protein, formate dehydrogenase is a protein

DS.d1187_task0

Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.

[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]

[ "protein", "compound" ]

propionate is a compound, fumarate is a compound, hydrogenase is a protein, formate dehydrogenase is a protein

DS.d1187_task1

Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please typing these entity words according to sentence: propionate, fumarate, hydrogenase, formate dehydrogenase Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.

[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]

[ "protein", "compound" ]

propionate, fumarate, hydrogenase, formate dehydrogenase

DS.d1187_task2

Sentence: Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.

[ "Depletion", "of", "tungsten", "and", "/", "or", "molybdenum", ",", "however", ",", "did", "not", "affect", "the", "growth", "of", "the", "pure", "culture", "of", "S.", "fumaroxidans", "on", "propionate", "plus", "fumarate", "significantly", ",", "although", "the", "specific", "activities", "of", "hydrogenase", "and", "especially", "formate", "dehydrogenase", "were", "influenced", "by", "the", "absence", "of", "Mo", "and", "W.", "This", "indicates", "that", "the", "organism", "has", "a", "low", "W", "or", "Mo", "requirement", "under", "these", "conditions", "." ]

[ "protein", "compound" ]

IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, CXCL8 is a Protein

208_task0

Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.

[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]

[ "Protein" ]

IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, IL-6 is a Protein, CXCL8 is a Protein, CXCL8 is a Protein, IL-6 is a Protein, CXCL8 is a Protein

208_task1

Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please typing these entity words according to sentence: IL-6, CXCL8, CXCL8, CXCL8, IL-6, IL-6, CXCL8, CXCL8, IL-6, CXCL8 Options: Protein

[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.

[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]

[ "Protein" ]

IL-6, CXCL8, CXCL8, CXCL8, IL-6, IL-6, CXCL8, CXCL8, IL-6, CXCL8

208_task2

Sentence: In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In the present study, IL-6 release was found to be associated with NF-kappaB activity while CXCL8 release more closely correlated with AP-1 activity. Treatment of Jurkat T-cells with PMA was more potent than HK E. coli at elevating the CXCL8 levels. PMA induced AP-1 activation and down-regulated NF-kappaB while HK E. coli up-regulated NF-kappaB without affecting AP-1 activity. In addition, the temporal induction pattern of AP-1 correlated to the release of CXCL8 while IL-6 followed the NF-kappaB activity. Likewise, blocking NF-kappaB activation resulted in a complete inhibition of IL-6 while the CXCL8 levels remained elevated as shown both at the protein and mRNA level. Furthermore, the CXCL8 release was down-regulated by inhibition of JNK activity. The present study indicates that in Jurkat T-cells, IL-6 is regulated through NF-kappaB while CXCL8 regulation is independent of NF-kappaB and closely associated with AP-1 activation.

[ "In", "the", "present", "study", ",", "IL-6", "release", "was", "found", "to", "be", "associated", "with", "NF", "-", "kappaB", "activity", "while", "CXCL8", "release", "more", "closely", "correlated", "with", "AP-1", "activity", ".", "Treatment", "of", "Jurkat", "T", "-", "cells", "with", "PMA", "was", "more", "potent", "than", "HK", "E.", "coli", "at", "elevating", "the", "CXCL8", "levels", ".", "PMA", "induced", "AP-1", "activation", "and", "down", "-", "regulated", "NF", "-", "kappaB", "while", "HK", "E.", "coli", "up", "-", "regulated", "NF", "-", "kappaB", "without", "affecting", "AP-1", "activity", ".", "In", "addition", ",", "the", "temporal", "induction", "pattern", "of", "AP-1", "correlated", "to", "the", "release", "of", "CXCL8", "while", "IL-6", "followed", "the", "NF", "-", "kappaB", "activity", ".", "Likewise", ",", "blocking", "NF", "-", "kappaB", "activation", "resulted", "in", "a", "complete", "inhibition", "of", "IL-6", "while", "the", "CXCL8", "levels", "remained", "elevated", "as", "shown", "both", "at", "the", "protein", "and", "mRNA", "level", ".", "Furthermore", ",", "the", "CXCL8", "release", "was", "down", "-", "regulated", "by", "inhibition", "of", "JNK", "activity", ".", "The", "present", "study", "indicates", "that", "in", "Jurkat", "T", "-", "cells", ",", "IL-6", "is", "regulated", "through", "NF", "-", "kappaB", "while", "CXCL8", "regulation", "is", "independent", "of", "NF", "-", "kappaB", "and", "closely", "associated", "with", "AP-1", "activation", "." ]

[ "Protein" ]

Sectio caesarea is an umlsterm, Hypertropher Obstruktiver Kardiomyopathie is an umlsterm

DerAnaesthesist.00490527.ger.abstr_task0

Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .

[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]

[ "umlsterm" ]

Sectio caesarea is an umlsterm, Hypertropher Obstruktiver Kardiomyopathie is an umlsterm

DerAnaesthesist.00490527.ger.abstr_task1

Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please typing these entity words according to sentence: Sectio caesarea, Hypertropher Obstruktiver Kardiomyopathie Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .

[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]

[ "umlsterm" ]

Sectio caesarea, Hypertropher Obstruktiver Kardiomyopathie

DerAnaesthesist.00490527.ger.abstr_task2

Sentence: Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird ueber das Vorgehen zur geplanten Sectio caesarea bei einer Patientin mit Hypertropher Obstruktiver Kardiomyopathie ( HOCM ) berichtet . Anhand dieses Falls werden die anaesthesiologisch zu beachtenden Besonderheiten dieses Krankheitsbilds diskutiert .

[ "Es", "wird", "ueber", "das", "Vorgehen", "zur", "geplanten", "Sectio", "caesarea", "bei", "einer", "Patientin", "mit", "Hypertropher", "Obstruktiver", "Kardiomyopathie", "(", "HOCM", ")", "berichtet", ".", "Anhand", "dieses", "Falls", "werden", "die", "anaesthesiologisch", "zu", "beachtenden", "Besonderheiten", "dieses", "Krankheitsbilds", "diskutiert", "." ]

[ "umlsterm" ]

Abstract is an umlsterm, Injuries is an umlsterm, posterior cruciate ligament is an umlsterm, injuries is an umlsterm, knee joint is an umlsterm, diagnosis is an umlsterm, injury is an umlsterm, treatment is an umlsterm, goal is an umlsterm, review is an umlsterm, anatomy is an umlsterm, biomechanics is an umlsterm, injury is an umlsterm, pathobiomechanics is an umlsterm, literature is an umlsterm, goal is an umlsterm, diagnostic is an umlsterm, clinical examination is an umlsterm, imaging techniques is an umlsterm, posterior cruciate ligament is an umlsterm, knees is an umlsterm, injuries is an umlsterm, anterior cruciate ligament is an umlsterm, injuries is an umlsterm, aim is an umlsterm

DerChirurg.00711066.eng.abstr_task0

Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .

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[ "umlsterm" ]

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DerChirurg.00711066.eng.abstr_task1

Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please typing these entity words according to sentence: Abstract, Injuries, posterior cruciate ligament, injuries, knee joint, diagnosis, injury, treatment, goal, review, anatomy, biomechanics, injury, pathobiomechanics, literature, goal, diagnostic, clinical examination, imaging techniques, posterior cruciate ligament, knees, injuries, anterior cruciate ligament, injuries, aim Options: umlsterm

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Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .

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[ "umlsterm" ]

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DerChirurg.00711066.eng.abstr_task2

Sentence: Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results . Instructions: please extract entity words from the input sentence

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Abstract . Injuries to the posterior cruciate ligament are among the major injuries to the knee joint . Today we are often confronted with an inapproprate and delayed diagnosis of this injury and its concomitant lesions . Additionally , the outcome of operative treatment has not yet reached an acceptable rate of satisfactory results . Therefore , the goal of this current concept review is to give a comprehensive insight into anatomy and biomechanics , injury mechanisms and pathobiomechanics , based on our experiences and data from the international literature . A further goal is to clarify diagnostic problems with respect to clinical examination and imaging techniques . We also present a differential concept for the perioperative and conservative management of posterior cruciate ligament deficient knees in order to also adequately address concomitant injuries such as posterolateral rotatory instability and combined anterior cruciate ligament injuries with the aim of further improving results .

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[ "umlsterm" ]

SERCA2 is a protein, M4 is a compound, oxygen is a compound, nitrogen is a compound

DS.d30_task0

Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

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Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.

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[ "compound", "protein" ]

SERCA2 is a protein, M4 is a compound, oxygen is a compound, nitrogen is a compound

DS.d30_task1

Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please typing these entity words according to sentence: SERCA2, M4, oxygen, nitrogen Options: compound, protein

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Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.

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[ "compound", "protein" ]

SERCA2, M4, oxygen, nitrogen

DS.d30_task2

Sentence: Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. Instructions: please extract entity words from the input sentence

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Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.

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[ "compound", "protein" ]

Medizintechnologien is an umlsterm, Genetik is an umlsterm, Wachstum is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Aerzten is an umlsterm, Medizintechnik is an umlsterm, Medizin- is an umlsterm, berufsrechtlich is an umlsterm, Embryonenschutzgesetz is an umlsterm, Praeimplantationsdiagnostik is an umlsterm, Berufsrecht is an umlsterm, Genetik is an umlsterm, familien- is an umlsterm, Elternschaft is an umlsterm

Reproduktionsmedizin.00160140.ger.abstr_task0

Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .

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[ "umlsterm" ]

Medizintechnologien is an umlsterm, Genetik is an umlsterm, Wachstum is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Aerzten is an umlsterm, Medizintechnik is an umlsterm, Medizin- is an umlsterm, berufsrechtlich is an umlsterm, Embryonenschutzgesetz is an umlsterm, Praeimplantationsdiagnostik is an umlsterm, Berufsrecht is an umlsterm, Genetik is an umlsterm, familien- is an umlsterm, Elternschaft is an umlsterm

Reproduktionsmedizin.00160140.ger.abstr_task1

Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please typing these entity words according to sentence: Medizintechnologien, Genetik, Wachstum, Diagnostik, Therapie, Aerzten, Medizintechnik, Medizin-, berufsrechtlich, Embryonenschutzgesetz, Praeimplantationsdiagnostik, Berufsrecht, Genetik, familien-, Elternschaft Options: umlsterm

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Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .

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[ "umlsterm" ]

Medizintechnologien, Genetik, Wachstum, Diagnostik, Therapie, Aerzten, Medizintechnik, Medizin-, berufsrechtlich, Embryonenschutzgesetz, Praeimplantationsdiagnostik, Berufsrecht, Genetik, familien-, Elternschaft

Reproduktionsmedizin.00160140.ger.abstr_task2

Sentence: Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln . Instructions: please extract entity words from the input sentence

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Die Synergieeffekte moderner Medizintechnologien in Fortpflanzungsmedizin und Genetik fuehren neben exponentiellem Wachstum der Moeglichkeiten in Diagnostik , Therapie und Praevention zur Notwendigkeit eines schnellen Wissenstransfers in die Oeffentlichkeit , um eine gesamtgesellschaftliche Konsensbildung herbeizufuehren . Aerzten und Wissenschaftlern kommt somit eine entscheidende Funktion nicht nur in der Fortentwicklung der Medizintechnik , sondern auch der Medizin- und Sozialethik zu . Die Bundesaerztekammer hat die Fortpflanzungsmedizin schon 1984 berufsrechtlich geregelt und seitdem staendig begleitet , darueber hinaus wurde vom Gesetzgeber 1990 die Notwendigkeit gesehen , eine bundesgesetzliche Regelung durch das Embryonenschutzgesetz zu schaffen . Heute , 10 Jahre spaeter , sind Aerzteschaft und Staat angesichts des gesamteuropaeischen Integrationsprozesses in unterschiedlichem Masse gefordert . Waehrend die Aerzteschaft kontinuierlich wie jetzt - fuer die Praeimplantationsdiagnostik - das Berufsrecht zu Fortpflanzungsmedizin und Genetik aktualisiert , ist es Sache des Bundesgesetzgebers , die primaer sozialrechtlich erforderlichen Rahmenbedingungen fuer eine ethisch vertretbare Fortpflanzungsmedizin - v. a. fuer Abstammungsrecht , Adoptionsvermittlungsgesetz , sowie familien- und erbrechtliche Fragen bei Auseinanderfallen genetischer und sozialer Elternschaft bei heterologer Befruchtung - zu entwickeln .

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[ "umlsterm" ]

aerobic exercise is a Intervention_Physical, cognition is a Outcome_Mental, Alzheimer ' s disease is a Participant_Condition, ( is a Intervention_Physical, ) is a Intervention_Physical, Aerobic exercise is a Intervention_Physical, moderate - intensity cycling intervention is a Intervention_Physical, older adults is a Participant_Age, mild - to - moderate Alzheimer ' s disease is a Participant_Condition, cognitive decline is a Outcome_Mental, Ninety is a Participant_Sample-size, low - intensity stretching is a Intervention_Control, Alzheimer ' s disease Assessment Scale - Cognition is a Outcome_Mental, Hippocampal volume is a Outcome_Physical, 90 is a Participant_Sample-size, exercise efficacy is a Outcome_Other, physical function and quality of life is a Outcome_Other, prohibitive costs is a Outcome_Other

68290_task0

Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .

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[ "Outcome_Mental", "Intervention_Physical", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Outcome_Physical", "Participant_Age", "Participant_Sample-size" ]

aerobic exercise is a Intervention_Physical, cognition is a Outcome_Mental, Alzheimer ' s disease is a Participant_Condition, ( is a Intervention_Physical, ) is a Intervention_Physical, Aerobic exercise is a Intervention_Physical, moderate - intensity cycling intervention is a Intervention_Physical, older adults is a Participant_Age, mild - to - moderate Alzheimer ' s disease is a Participant_Condition, cognitive decline is a Outcome_Mental, Ninety is a Participant_Sample-size, low - intensity stretching is a Intervention_Control, Alzheimer ' s disease Assessment Scale - Cognition is a Outcome_Mental, Hippocampal volume is a Outcome_Physical, 90 is a Participant_Sample-size, exercise efficacy is a Outcome_Other, physical function and quality of life is a Outcome_Other, prohibitive costs is a Outcome_Other

68290_task1

Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please typing these entity words according to sentence: aerobic exercise, cognition, Alzheimer ' s disease, (, ), Aerobic exercise, moderate - intensity cycling intervention, older adults, mild - to - moderate Alzheimer ' s disease, cognitive decline, Ninety, low - intensity stretching, Alzheimer ' s disease Assessment Scale - Cognition, Hippocampal volume, 90, exercise efficacy, physical function and quality of life, prohibitive costs Options: Intervention_Physical, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .

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[ "Outcome_Mental", "Intervention_Physical", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Outcome_Physical", "Participant_Age", "Participant_Sample-size" ]

aerobic exercise, cognition, Alzheimer ' s disease, (, ), Aerobic exercise, moderate - intensity cycling intervention, older adults, mild - to - moderate Alzheimer ' s disease, cognitive decline, Ninety, low - intensity stretching, Alzheimer ' s disease Assessment Scale - Cognition, Hippocampal volume, 90, exercise efficacy, physical function and quality of life, prohibitive costs

68290_task2

Sentence: Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) . Instructions: please extract entity words from the input sentence

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Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer 's disease : study protocol of a randomized controlled trial ( The FIT-AD trial ) . BACKGROUND Alzheimer 's disease , a global public health issue , accounts for 60 to 80 % of all dementias . Alzheimer 's disease primarily causes cognitive impairment and drugs have only modest short-term effects , highlighting a pressing need to develop effective interventions . Aerobic exercise holds promise for treating cognitive impairment in Alzheimer 's disease through biologically sound mechanisms . Nonetheless , aerobic exercise studies in Alzheimer 's disease are limited with mixed findings . METHODS/DESIGN This pilot randomized controlled trial will investigate the effects of a 6-month , individualized , moderate-intensity cycling intervention ( 20 to 50 minutes per session , 3 times a week ) on cognition and hippocampal volume in community-dwelling older adults with mild-to-moderate Alzheimer 's disease . The specific aims are to : 1 ) determine the immediate effect of the cycling intervention on cognition in Alzheimer 's disease ; 2 ) examine if the cycling intervention slows cognitive decline in Alzheimer 's disease from baseline to 12 months ; and 3 ) assess the effect of aerobic exercise on hippocampal volume over 12 months . Ninety subjects will be randomized on a 2:1 allocation ratio to cycling or attention control ( low-intensity stretching ) and followed for another 6 months . Allocations will be concealed to all investigators and outcome assessors will be blinded to group assignments and previous data . Cognition will be measured by the Alzheimer 's disease Assessment Scale-Cognition at baseline before randomization and at 3 , 6 , 9 , and 12 months . Hippocampal volume will be measured by magnetic resonance imaging at baseline and 6 and 12 months . The sample size of 90 will give 80 % power to detect a 2.5-point difference in within-group changes in the Alzheimer 's disease Assessment Scale-Cognition at 6 months for the cycling group . DISCUSSION Findings from this study will address the critical gap of exercise efficacy in Alzheimer 's disease and use of magnetic resonance imaging as an outcome measure in clinical trials . This study will provide a potential treatment that may increase physical function and quality of life and curb the prohibitive costs for the growing dementia population . TRIAL REGISTRATION Primary registration : ( NCT01954550 ; date of registration : 20 September 2013 ) . Secondary registration : ( NCT01954550 ; date of registration : 1 October 2013 ) .

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[ "Outcome_Mental", "Intervention_Physical", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Outcome_Physical", "Participant_Age", "Participant_Sample-size" ]

insulin is a Intervention_Pharmacological, whole - body protein turnover is a Outcome_Physical, parenterally - fed undernourished patients . is a Participant_Condition, Ten is a Participant_Sample-size, 1 - 2 units insulin / kg body weight/24 h with their feed is a Intervention_Pharmacological, received the feed only is a Intervention_Control, rates of whole - body protein synthesis and breakdown is a Outcome_Physical, 15N - glycine is a Intervention_Pharmacological, blood glucose is a Outcome_Physical, plasma insulin and glucagon is a Outcome_Physical, urinary ammonia is a Outcome_Physical, nitrogen is a Outcome_Physical, creatinine and 3-methylhistidine is a Outcome_Physical, Blood glucose is a Outcome_Physical, plasma insulin and glucagon concentrations is a Outcome_Physical, insulin concentration is a Outcome_Physical, Apparent nitrogen balance is a Outcome_Physical, urinary excretion of ammonia is a Outcome_Physical, Protein turnover is a Outcome_Physical, ammonia end - product is a Outcome_Physical

79142_task0

Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size

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The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]

insulin is a Intervention_Pharmacological, whole - body protein turnover is a Outcome_Physical, parenterally - fed undernourished patients . is a Participant_Condition, Ten is a Participant_Sample-size, 1 - 2 units insulin / kg body weight/24 h with their feed is a Intervention_Pharmacological, received the feed only is a Intervention_Control, rates of whole - body protein synthesis and breakdown is a Outcome_Physical, 15N - glycine is a Intervention_Pharmacological, blood glucose is a Outcome_Physical, plasma insulin and glucagon is a Outcome_Physical, urinary ammonia is a Outcome_Physical, nitrogen is a Outcome_Physical, creatinine and 3-methylhistidine is a Outcome_Physical, Blood glucose is a Outcome_Physical, plasma insulin and glucagon concentrations is a Outcome_Physical, insulin concentration is a Outcome_Physical, Apparent nitrogen balance is a Outcome_Physical, urinary excretion of ammonia is a Outcome_Physical, Protein turnover is a Outcome_Physical, ammonia end - product is a Outcome_Physical

79142_task1

Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please typing these entity words according to sentence: insulin, whole - body protein turnover, parenterally - fed undernourished patients ., Ten, 1 - 2 units insulin / kg body weight/24 h with their feed, received the feed only, rates of whole - body protein synthesis and breakdown, 15N - glycine, blood glucose, plasma insulin and glucagon, urinary ammonia, nitrogen, creatinine and 3-methylhistidine, Blood glucose, plasma insulin and glucagon concentrations, insulin concentration, Apparent nitrogen balance, urinary excretion of ammonia, Protein turnover, ammonia end - product Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size

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The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]

insulin, whole - body protein turnover, parenterally - fed undernourished patients ., Ten, 1 - 2 units insulin / kg body weight/24 h with their feed, received the feed only, rates of whole - body protein synthesis and breakdown, 15N - glycine, blood glucose, plasma insulin and glucagon, urinary ammonia, nitrogen, creatinine and 3-methylhistidine, Blood glucose, plasma insulin and glucagon concentrations, insulin concentration, Apparent nitrogen balance, urinary excretion of ammonia, Protein turnover, ammonia end - product

79142_task2

Sentence: The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery . Instructions: please extract entity words from the input sentence

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The effect of surgical trauma and insulin on whole-body protein turnover in parenterally-fed undernourished patients . Ten undernourished patients receiving total parenteral nutrition and undergoing major intestinal surgery were restarted on intravenous feeds identical to their pre-operative regimens within 24 h of their operation . Five , chosen at random , received post-operatively 1-2 units insulin/kg body weight/24 h with their feed , while the other five received the feed only . Pre-operatively , and 2 h after commencing their post-operative feeds , rates of whole-body protein synthesis and breakdown were measured over a 9-h period following intravenous injection of a single tracer dose of 15N-glycine by the ammonia and urea end-product methods . During these 9-h study periods measurements were also made of blood glucose , plasma insulin and glucagon , urinary ammonia , nitrogen , creatinine and 3-methylhistidine . Blood glucose and plasma insulin and glucagon concentrations rose post-operatively whether or not insulin was given , but the increment in insulin concentration was significantly greater when insulin was given . Apparent nitrogen balance was positive pre-operatively and became less so post-operatively whether insulin was given or not . Similarly , post-operative increments in urinary excretion of ammonia , creatinine and 3-methylhistidine were not altered by addition of insulin . Protein turnover , as estimated by the ammonia end-product method , tended to rise post-operatively , but there was no significant difference between the increases observed with or without insulin . The urea end-product method suggested that there was no change in whole-body protein turnover after surgery , whether or not insulin was given . This study does not support the clinical use of insulin as a means of modifying protein metabolic losses after major surgery .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Sample-size" ]

14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, phosphoserine is a Simple_chemical, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F2 is a Gene_or_gene_product, E2F3 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, p73 is a Gene_or_gene_product, Apaf-1 is a Gene_or_gene_product, caspases is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product

132_task0

Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Gene_or_gene_product

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A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.

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[ "Simple_chemical", "Gene_or_gene_product" ]

14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, phosphoserine is a Simple_chemical, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, ATM is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, E2F2 is a Gene_or_gene_product, E2F3 is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product, p73 is a Gene_or_gene_product, Apaf-1 is a Gene_or_gene_product, caspases is a Gene_or_gene_product, 14 - 3 - 3 tau is a Gene_or_gene_product, E2F1 is a Gene_or_gene_product

132_task1

Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. Instructions: please typing these entity words according to sentence: 14 - 3 - 3 tau, E2F1, E2F1, E2F1, E2F1, ATM, ATM, E2F1, 14 - 3 - 3 tau, phosphoserine, E2F1, 14 - 3 - 3 tau, ATM, E2F1, E2F1, 14 - 3 - 3 tau, E2F1, E2F2, E2F3, 14 - 3 - 3 tau, E2F1, p73, Apaf-1, caspases, 14 - 3 - 3 tau, E2F1 Options: Simple_chemical, Gene_or_gene_product

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A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.

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[ "Simple_chemical", "Gene_or_gene_product" ]

14 - 3 - 3 tau, E2F1, E2F1, E2F1, E2F1, ATM, ATM, E2F1, 14 - 3 - 3 tau, phosphoserine, E2F1, 14 - 3 - 3 tau, ATM, E2F1, E2F1, 14 - 3 - 3 tau, E2F1, E2F2, E2F3, 14 - 3 - 3 tau, E2F1, p73, Apaf-1, caspases, 14 - 3 - 3 tau, E2F1

132_task2

Sentence: A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. Instructions: please extract entity words from the input sentence

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A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We now show that 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage.

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[ "Simple_chemical", "Gene_or_gene_product" ]

Therapie is an umlsterm, radiologischen is an umlsterm, Arthrosegrad is an umlsterm, Behandlung is an umlsterm, bildgebender is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Synovialitis is an umlsterm

DerOrthopaede.90280812.ger.abstr_task0

Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .

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Therapie is an umlsterm, radiologischen is an umlsterm, Arthrosegrad is an umlsterm, Behandlung is an umlsterm, bildgebender is an umlsterm, Patienten is an umlsterm, Diagnostik is an umlsterm, Synovialitis is an umlsterm

DerOrthopaede.90280812.ger.abstr_task1

Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . Instructions: please typing these entity words according to sentence: Therapie, radiologischen, Arthrosegrad, Behandlung, bildgebender, Patienten, Diagnostik, Synovialitis Options: umlsterm

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Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .

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[ "umlsterm" ]

Therapie, radiologischen, Arthrosegrad, Behandlung, bildgebender, Patienten, Diagnostik, Synovialitis

DerOrthopaede.90280812.ger.abstr_task2

Sentence: Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern . Instructions: please extract entity words from the input sentence

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Persistierende Hueftbeschwerden trotz intensiver konservativer Therapie bei einem radiologischen Arthrosegrad von 2-5 nach Danielsson stellen uns vor das Problem der weiteren Behandlung . Aufgrund der unzureichenden Aussagekraft bildgebender Verfahren und Berichten ueber Behandlungserfolge durch arthroskopische Eingriffe wurden von November 1997 bis September 1998 bei 17 Patienten mit oben beschriebener Problematik Hueftarthroskopien durchgefuehrt . Intraoperativ waren die degenerativen Veraenderungen ausgepraegter , als dies aufgrund der praeoperativen Diagnostik zu erwarten gewesen waere . Es fanden sich pathologische Veraenderungen wie freie Koerper , osteochondrale Fragmente , Labrumlaesionen , einklemmende Osteophyten und eine zottige Synovialitis . Ueber eine Gelenklavage und ein Debridement hinaus konnten freie Koerper und osteochondrale Fragmente entfernt , Labrumlaesionen geglaettet und Osteophyten abgefraest werden . Eine klinische Nachuntersuchung nach 1 Monat ( n = 15 ) zeigte eine Befundbesserung im Harris-Hip-Score um durchschnittlich 13 Punkte und eine subjektive Beschwerdebesserung von durchschnittlich 39 % . Nach 6 Monaten ( n = 9 ) ergab sich im Harris-Hip-Score eine Befundbesserung von durchschnittlich 14 Punkten und eine subjektive Beschwerdebesserung von durchschnittlich 32 % . Ueber den therapeutischen Effekt hinaus bot die Hueftarthroskopie die Moeglichkeit , einen genauen intraartikulaeren Status zu erheben , um so Entscheidungen ueber das weitere therapeutische Vorgehen zu erleichtern .

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[ "umlsterm" ]

TGF - β is a GENE-N, cytokines is a GENE-N, chemokines is a GENE-N, Transforming growth factor beta is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, MAPK is a GENE-N, PI3 K is a GENE-N, WNT is a GENE-N, β - catenin is a GENE-Y, Ca(2 + ) is a CHEMICAL, TGF - β is a GENE-N

6988_task0

Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

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Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TGF - β is a GENE-N, cytokines is a GENE-N, chemokines is a GENE-N, Transforming growth factor beta is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, TGF - β is a GENE-N, MAPK is a GENE-N, PI3 K is a GENE-N, WNT is a GENE-N, β - catenin is a GENE-Y, Ca(2 + ) is a CHEMICAL, TGF - β is a GENE-N

6988_task1

Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please typing these entity words according to sentence: TGF - β, cytokines, chemokines, Transforming growth factor beta, TGF - β, TGF - β, TGF - β, MAPK, PI3 K, WNT, β - catenin, Ca(2 + ), TGF - β Options: GENE-Y, GENE-N, CHEMICAL

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Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TGF - β, cytokines, chemokines, Transforming growth factor beta, TGF - β, TGF - β, TGF - β, MAPK, PI3 K, WNT, β - catenin, Ca(2 + ), TGF - β

6988_task2

Sentence: Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed. Instructions: please extract entity words from the input sentence

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Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities of the ASM in asthma and COPD. It is increasingly evident that TGF-β functions as a master switch, controlling a network of intracellular and autocrine signaling loops that effect ASM phenotype and function. In this review, the various elements that participate in non-canonical TGF-β signaling, including MAPK, PI3K, WNT/β-catenin, and Ca(2+), are discussed, focusing on their effect on ASM phenotype and function. In addition, new aspects of ASM biology and their possible association with non-canonical TGF-β signaling will be discussed.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

female sterilization procedure is a Procedure, Desire is a Mood, conception is a Observation, in the next 12 months is a Temporal, Not is a Negation, sexually active is a Observation, male partner is a Qualifier

NCT02267616_exc_task0

Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Qualifier, Observation, Procedure, Negation, Mood

[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Negation", "B-Observation", "I-Observation", "O", "O", "B-Qualifier", "I-Qualifier", "O" ]

Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner

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[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]

female sterilization procedure is a Procedure, Desire is a Mood, conception is a Observation, in the next 12 months is a Temporal, Not is a Negation, sexually active is a Observation, male partner is a Qualifier

NCT02267616_exc_task1

Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please typing these entity words according to sentence: female sterilization procedure, Desire, conception, in the next 12 months, Not, sexually active, male partner Options: Temporal, Qualifier, Observation, Procedure, Negation, Mood

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Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner

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[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]

female sterilization procedure, Desire, conception, in the next 12 months, Not, sexually active, male partner

NCT02267616_exc_task2

Sentence: Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Negation", "B-Observation", "I-Observation", "O", "O", "B-Qualifier", "I-Qualifier", "O" ]

Have history of female sterilization procedure Desire for conception in the next 12 months Not sexually active with a male partner

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[ "Procedure", "Temporal", "Observation", "Qualifier", "Mood", "Negation" ]

diacylglycerol acyltransferase is a GENE-Y, prenylflavonoids is a CHEMICAL, prenylflavonoids is a CHEMICAL, kurarinone is a CHEMICAL, chalcone is a CHEMICAL, kuraridin is a CHEMICAL, kurarinol is a CHEMICAL, kushenol H is a CHEMICAL, kushenol K is a CHEMICAL, diacylglycerol acyltransferase is a GENE-Y, DGAT is a GENE-Y, flavonoids is a CHEMICAL, DGAT is a GENE-Y, prenylflavonoids is a CHEMICAL, C3-OH is a CHEMICAL, C3-OH is a CHEMICAL, flavonoids is a CHEMICAL, hesperetin is a CHEMICAL, naringenin is a CHEMICAL, quercetin is a CHEMICAL, kaempferol is a CHEMICAL, lavandulyl is a CHEMICAL, hydroxy is a CHEMICAL, DGAT is a GENE-Y, triacylglycerol is a CHEMICAL, TG is a CHEMICAL

30225_task0

Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

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In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.

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[ "GENE-Y", "CHEMICAL" ]

diacylglycerol acyltransferase is a GENE-Y, prenylflavonoids is a CHEMICAL, prenylflavonoids is a CHEMICAL, kurarinone is a CHEMICAL, chalcone is a CHEMICAL, kuraridin is a CHEMICAL, kurarinol is a CHEMICAL, kushenol H is a CHEMICAL, kushenol K is a CHEMICAL, diacylglycerol acyltransferase is a GENE-Y, DGAT is a GENE-Y, flavonoids is a CHEMICAL, DGAT is a GENE-Y, prenylflavonoids is a CHEMICAL, C3-OH is a CHEMICAL, C3-OH is a CHEMICAL, flavonoids is a CHEMICAL, hesperetin is a CHEMICAL, naringenin is a CHEMICAL, quercetin is a CHEMICAL, kaempferol is a CHEMICAL, lavandulyl is a CHEMICAL, hydroxy is a CHEMICAL, DGAT is a GENE-Y, triacylglycerol is a CHEMICAL, TG is a CHEMICAL

30225_task1

Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please typing these entity words according to sentence: diacylglycerol acyltransferase, prenylflavonoids, prenylflavonoids, kurarinone, chalcone, kuraridin, kurarinol, kushenol H, kushenol K, diacylglycerol acyltransferase, DGAT, flavonoids, DGAT, prenylflavonoids, C3-OH, C3-OH, flavonoids, hesperetin, naringenin, quercetin, kaempferol, lavandulyl, hydroxy, DGAT, triacylglycerol, TG Options: GENE-Y, CHEMICAL

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In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.

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[ "GENE-Y", "CHEMICAL" ]

diacylglycerol acyltransferase, prenylflavonoids, prenylflavonoids, kurarinone, chalcone, kuraridin, kurarinol, kushenol H, kushenol K, diacylglycerol acyltransferase, DGAT, flavonoids, DGAT, prenylflavonoids, C3-OH, C3-OH, flavonoids, hesperetin, naringenin, quercetin, kaempferol, lavandulyl, hydroxy, DGAT, triacylglycerol, TG

30225_task2

Sentence: In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells. Instructions: please extract entity words from the input sentence

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In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 microM ( 1), 9.8 microM ( 2), 8.6 microM ( 3), 142.0 microM ( 4) and 250 microM ( 5). The prenylflavonoids without C3-OH ( 1, 2, 3) showed stronger inhibition than those with C3-OH ( 4, 5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 microM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.

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[ "GENE-Y", "CHEMICAL" ]

Mitochondrial electron transfer chain complexes is a GENE-N, organochalcogens is a CHEMICAL

23103426_task0

Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL

[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]

Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.

[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Mitochondrial electron transfer chain complexes is a GENE-N, organochalcogens is a CHEMICAL

23103426_task1

Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please typing these entity words according to sentence: Mitochondrial electron transfer chain complexes, organochalcogens Options: GENE-N, CHEMICAL

[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]

Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.

[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Mitochondrial electron transfer chain complexes, organochalcogens

23103426_task2

Sentence: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O" ]

Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.

[ "Mitochondrial", "electron", "transfer", "chain", "complexes", "inhibition", "by", "different", "organochalcogens", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

LEAP , TEACCH is a Intervention_Educational, non - model - specific special education programs is a Intervention_Educational, preschoolers is a Participant_Age, autism spectrum disorders is a Participant_Condition, LEAP and TEACCH is a Intervention_Educational, young children is a Participant_Age, high fidelity LEAP is a Intervention_Educational, 198 is a Participant_Sample-size

60280_task0

Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Participant_Age, Participant_Condition, Participant_Sample-size

[ "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]

LEAP , TEACCH is a Intervention_Educational, non - model - specific special education programs is a Intervention_Educational, preschoolers is a Participant_Age, autism spectrum disorders is a Participant_Condition, LEAP and TEACCH is a Intervention_Educational, young children is a Participant_Age, high fidelity LEAP is a Intervention_Educational, 198 is a Participant_Sample-size

60280_task1

Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please typing these entity words according to sentence: LEAP , TEACCH, non - model - specific special education programs, preschoolers, autism spectrum disorders, LEAP and TEACCH, young children, high fidelity LEAP, 198 Options: Intervention_Educational, Participant_Age, Participant_Condition, Participant_Sample-size

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Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]

LEAP , TEACCH, non - model - specific special education programs, preschoolers, autism spectrum disorders, LEAP and TEACCH, young children, high fidelity LEAP, 198

60280_task2

Sentence: Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM . Instructions: please extract entity words from the input sentence

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Comparative efficacy of LEAP , TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders . LEAP and TEACCH represent two comprehensive treatment models ( CTMs ) that have been widely used across several decades to educate young children with autism spectrum disorders . The purpose of this quasi-experimental study was to compare high fidelity LEAP ( n = 22 ) and TEACCH ( n = 25 ) classrooms to each other and a control condition ( n = 28 ) , in which teachers in high quality special education programs used non-model-specific practices . A total of 198 children were included in data analysis . Across conditions , children 's performances improved over time . This study raises issues of the replication of effects for CTMs , and whether having access to a high quality special education program is as beneficial as access to a specific CTM .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]

Patienten is an umlsterm, Gesichtes is an umlsterm, Halses is an umlsterm, Gastroenteritis is an umlsterm, Asthma bronchiale is an umlsterm, Eosinophilie is an umlsterm, Differentialblutbild is an umlsterm, Hautbiopsien is an umlsterm, Magen- is an umlsterm, Duodenalschleimhaut is an umlsterm, Gastroenteritis is an umlsterm, Eosinophilie is an umlsterm, Literatur is an umlsterm, Syndromen is an umlsterm, Gastroenteritis is an umlsterm, Angiooedem is an umlsterm, Eosinophilie is an umlsterm

DerHautarzt.80490566.ger.abstr_task0

Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .

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[ "umlsterm" ]

Patienten is an umlsterm, Gesichtes is an umlsterm, Halses is an umlsterm, Gastroenteritis is an umlsterm, Asthma bronchiale is an umlsterm, Eosinophilie is an umlsterm, Differentialblutbild is an umlsterm, Hautbiopsien is an umlsterm, Magen- is an umlsterm, Duodenalschleimhaut is an umlsterm, Gastroenteritis is an umlsterm, Eosinophilie is an umlsterm, Literatur is an umlsterm, Syndromen is an umlsterm, Gastroenteritis is an umlsterm, Angiooedem is an umlsterm, Eosinophilie is an umlsterm

DerHautarzt.80490566.ger.abstr_task1

Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please typing these entity words according to sentence: Patienten, Gesichtes, Halses, Gastroenteritis, Asthma bronchiale, Eosinophilie, Differentialblutbild, Hautbiopsien, Magen-, Duodenalschleimhaut, Gastroenteritis, Eosinophilie, Literatur, Syndromen, Gastroenteritis, Angiooedem, Eosinophilie Options: umlsterm

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Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .

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[ "umlsterm" ]

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DerHautarzt.80490566.ger.abstr_task2

Sentence: Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt . Instructions: please extract entity words from the input sentence

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Wir beschreiben einen 23jaehrigen Patienten mit rezidivierenden Angiooedemen des Gesichtes und des Halses und begleitender Gastroenteritis . Zusaetzlich bestanden ein Asthma bronchiale eine Polyposis nasi und eine Rhinoconjunctivitis allergica . , Neben einer Eosinophilie im Differentialblutbild fanden sich histologisch eosinophile Infiltrate sowohl in den Hautbiopsien als auch in der Oesophagus- , Magen- und Duodenalschleimhaut . Unter systemischer Kortikosteroidtherapie kam es zu einer kompletten Rueckbildung der Angiooedeme , der Gastroenteritis und der Eosinophilie . Das von uns vorgestellte Krankheitsbild zeigt deutliche Parallelen zu seltenen in der Literatur beschriebenen Syndromen ( eosinophile Gastroenteritis , Samter-Syndrom , episodisches Angiooedem mit Eosinophilie ) , ist aber u.W. nach in dieser Symptomenkonstellation bisher noch nicht bekannt .

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[ "umlsterm" ]