bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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prophylaxis is an umlsterm, therapy is an umlsterm, ointment is an umlsterm, glass is an umlsterm, glass is an umlsterm, patients is an umlsterm, feeling is an umlsterm, physical handicap is an umlsterm, therapeutic is an umlsterm, gravity is an umlsterm, gold is an umlsterm, implantation is an umlsterm, Methods is an umlsterm, patients is an umlsterm, lead is an umlsterm, weights is an umlsterm, patients is an umlsterm, adhesive is an umlsterm, skin is an umlsterm, method is an umlsterm, persons is an umlsterm, patients is an umlsterm, method is an umlsterm, patients is an umlsterm, procedure is an umlsterm, visual function is an umlsterm, cosmetics is an umlsterm, glass is an umlsterm, lead is an umlsterm, weights is an umlsterm, adhesive is an umlsterm, method is an umlsterm, gold is an umlsterm, implantation is an umlsterm	DerNervenarzt.60670667.eng.abstr_task1	Sentence: Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation . Instructions: please typing these entity words according to sentence: prophylaxis, therapy, ointment, glass, glass, patients, feeling, physical handicap, therapeutic, gravity, gold, implantation, Methods, patients, lead, weights, patients, adhesive, skin, method, persons, patients, method, patients, procedure, visual function, cosmetics, glass, lead, weights, adhesive, method, gold, implantation Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation .	[ "Background", ":", "For", "prophylaxis", "or", "therapy", "of", "lagophthalmic", "keratopathy", "ointment", "application", "or", "hour", "glass", "dressing", "is", "indicated", ".", "The", "hour", "glass", "dressing", "has", "the", "disadvantage", "of", "a", "continuous", "visual", "impairment", "by", "steaming", "up", "of", "the", "moisture", "chamber", ".", "The", "main", "problem", "for", "the", "patients", "is", "the", "strong", "subjective", "feeling", "of", "physical", "handicap", ".", "A", "therapeutic", "alternative", "is", "the", "gravity", "dependent", "lidloading", ",", "which", "is", "known", "as", "gold", "implantation", "in", "cases", "of", "irreversible", "lagophthalmos", ".", "Methods", "and", "patients", ":", "By", "lead", "weights", "of", "0,8", "to", "2,0", "g", ",", "which", "are", "fixed", "to", "the", "upper", "lid", "by", "a", "foil", "glueing", "on", "both", "sides", "(", "Tesafix", ")", "or", "in", "allergic", "patients", "by", "an", "adhesive", "layer", ",", "well", "tolerated", "by", "the", "skin", "(", "Combihesive", ")", ",", "the", "lidclosure", "can", "become", "restored", "without", "impairment", "of", "lidopening", ".", "In", "a", "controlled", "study", "the", "described", "method", "was", "first", "tested", "on", "10", "normal", "persons", "and", "than", "applied", "to", "22", "patients", "with", "lagophthalmos", ".", "Meanwhile", "the", "new", "method", "was", "applied", "to", "32", "further", "patients", ".", "Results", ":", "The", "\"", "liddynamic", "\"", "procedure", "is", "effective", "and", "well", "tolerated", ";", "it", "is", "more", "accepted", ",", "especially", "during", "the", "day", ",", "because", "of", "better", "visual", "function", "and", "better", "cosmetics", ".", "The", "hour", "glass", "dressing", ",", "is", "still", "of", "importance", "in", "serious", "cases", "of", "kerathopathy", "during", "the", "night", ".", "Conclusion", ":", "\"", "lidloading", "\"", "with", "lead", "weights", ",", "which", "are", "glued", "by", "an", "adhesive", "layer", "to", "the", "upper", "lid", ",", "can", "be", "recommended", "as", "a", "new", "method", "in", "cases", "of", "reversible", "lagophthalmos", "or", "as", "a", "preparing", "step", "before", "a", "gold", "implantation", "." ]	[ "umlsterm" ]
prophylaxis, therapy, ointment, glass, glass, patients, feeling, physical handicap, therapeutic, gravity, gold, implantation, Methods, patients, lead, weights, patients, adhesive, skin, method, persons, patients, method, patients, procedure, visual function, cosmetics, glass, lead, weights, adhesive, method, gold, implantation	DerNervenarzt.60670667.eng.abstr_task2	Sentence: Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation .	[ "Background", ":", "For", "prophylaxis", "or", "therapy", "of", "lagophthalmic", "keratopathy", "ointment", "application", "or", "hour", "glass", "dressing", "is", "indicated", ".", "The", "hour", "glass", "dressing", "has", "the", "disadvantage", "of", "a", "continuous", "visual", "impairment", "by", "steaming", "up", "of", "the", "moisture", "chamber", ".", "The", "main", "problem", "for", "the", "patients", "is", "the", "strong", "subjective", "feeling", "of", "physical", "handicap", ".", "A", "therapeutic", "alternative", "is", "the", "gravity", "dependent", "lidloading", ",", "which", "is", "known", "as", "gold", "implantation", "in", "cases", "of", "irreversible", "lagophthalmos", ".", "Methods", "and", "patients", ":", "By", "lead", "weights", "of", "0,8", "to", "2,0", "g", ",", "which", "are", "fixed", "to", "the", "upper", "lid", "by", "a", "foil", "glueing", "on", "both", "sides", "(", "Tesafix", ")", "or", "in", "allergic", "patients", "by", "an", "adhesive", "layer", ",", "well", "tolerated", "by", "the", "skin", "(", "Combihesive", ")", ",", "the", "lidclosure", "can", "become", "restored", "without", "impairment", "of", "lidopening", ".", "In", "a", "controlled", "study", "the", "described", "method", "was", "first", "tested", "on", "10", "normal", "persons", "and", "than", "applied", "to", "22", "patients", "with", "lagophthalmos", ".", "Meanwhile", "the", "new", "method", "was", "applied", "to", "32", "further", "patients", ".", "Results", ":", "The", "\"", "liddynamic", "\"", "procedure", "is", "effective", "and", "well", "tolerated", ";", "it", "is", "more", "accepted", ",", "especially", "during", "the", "day", ",", "because", "of", "better", "visual", "function", "and", "better", "cosmetics", ".", "The", "hour", "glass", "dressing", ",", "is", "still", "of", "importance", "in", "serious", "cases", "of", "kerathopathy", "during", "the", "night", ".", "Conclusion", ":", "\"", "lidloading", "\"", "with", "lead", "weights", ",", "which", "are", "glued", "by", "an", "adhesive", "layer", "to", "the", "upper", "lid", ",", "can", "be", "recommended", "as", "a", "new", "method", "in", "cases", "of", "reversible", "lagophthalmos", "or", "as", "a", "preparing", "step", "before", "a", "gold", "implantation", "." ]	[ "umlsterm" ]
symptoms is an umlsterm, odontogenic tumors is an umlsterm, bone is an umlsterm, Root resorptions is an umlsterm, development is an umlsterm, today 's is an umlsterm, classification is an umlsterm, odontogenic tumors is an umlsterm, neoplasm is an umlsterm, therapeutic is an umlsterm, malignant is an umlsterm, tumors is an umlsterm, recurrences is an umlsterm	MundKieferGesichtschirurgie.0004s187.eng.abstr_task0	Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .	[ "The", "clinical", "symptoms", "of", "odontogenic", "tumors", "are", "non", "-", "specific", ".", "On", "the", "roentgenographs", "one", "most", "often", "sees", "radiolucencies", "within", "the", "bone", ",", "sometimes", "in", "combination", "with", "scattered", "or", "diffuse", "radioopacities", ".", "Root", "resorptions", "may", "be", "another", "important", "feature", ".", "After", "a", "short", "historical", "introduction", "on", "the", "development", "of", "today", "'s", "classification", "of", "odontogenic", "tumors", "(", "WHO", ")", ",", "each", "individual", "type", "of", "neoplasm", "is", "discussed", "briefly", ".", "Out", "of", "this", ",", "a", "therapeutic", "regime", "is", "developed", "that", "places", "each", "of", "the", "22", "entities", "into", "one", "of", "the", "following", "four", "groups", ":", "malignant", ",", "locally", "aggressive", ",", "tumors", "with", "recurrences", ",", "and", "non", "-", "recurrent", "ones", "." ]	[ "umlsterm" ]
symptoms is an umlsterm, odontogenic tumors is an umlsterm, bone is an umlsterm, Root resorptions is an umlsterm, development is an umlsterm, today 's is an umlsterm, classification is an umlsterm, odontogenic tumors is an umlsterm, neoplasm is an umlsterm, therapeutic is an umlsterm, malignant is an umlsterm, tumors is an umlsterm, recurrences is an umlsterm	MundKieferGesichtschirurgie.0004s187.eng.abstr_task1	Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please typing these entity words according to sentence: symptoms, odontogenic tumors, bone, Root resorptions, development, today 's, classification, odontogenic tumors, neoplasm, therapeutic, malignant, tumors, recurrences Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .	[ "The", "clinical", "symptoms", "of", "odontogenic", "tumors", "are", "non", "-", "specific", ".", "On", "the", "roentgenographs", "one", "most", "often", "sees", "radiolucencies", "within", "the", "bone", ",", "sometimes", "in", "combination", "with", "scattered", "or", "diffuse", "radioopacities", ".", "Root", "resorptions", "may", "be", "another", "important", "feature", ".", "After", "a", "short", "historical", "introduction", "on", "the", "development", "of", "today", "'s", "classification", "of", "odontogenic", "tumors", "(", "WHO", ")", ",", "each", "individual", "type", "of", "neoplasm", "is", "discussed", "briefly", ".", "Out", "of", "this", ",", "a", "therapeutic", "regime", "is", "developed", "that", "places", "each", "of", "the", "22", "entities", "into", "one", "of", "the", "following", "four", "groups", ":", "malignant", ",", "locally", "aggressive", ",", "tumors", "with", "recurrences", ",", "and", "non", "-", "recurrent", "ones", "." ]	[ "umlsterm" ]
symptoms, odontogenic tumors, bone, Root resorptions, development, today 's, classification, odontogenic tumors, neoplasm, therapeutic, malignant, tumors, recurrences	MundKieferGesichtschirurgie.0004s187.eng.abstr_task2	Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .	[ "The", "clinical", "symptoms", "of", "odontogenic", "tumors", "are", "non", "-", "specific", ".", "On", "the", "roentgenographs", "one", "most", "often", "sees", "radiolucencies", "within", "the", "bone", ",", "sometimes", "in", "combination", "with", "scattered", "or", "diffuse", "radioopacities", ".", "Root", "resorptions", "may", "be", "another", "important", "feature", ".", "After", "a", "short", "historical", "introduction", "on", "the", "development", "of", "today", "'s", "classification", "of", "odontogenic", "tumors", "(", "WHO", ")", ",", "each", "individual", "type", "of", "neoplasm", "is", "discussed", "briefly", ".", "Out", "of", "this", ",", "a", "therapeutic", "regime", "is", "developed", "that", "places", "each", "of", "the", "22", "entities", "into", "one", "of", "the", "following", "four", "groups", ":", "malignant", ",", "locally", "aggressive", ",", "tumors", "with", "recurrences", ",", "and", "non", "-", "recurrent", "ones", "." ]	[ "umlsterm" ]
efficacy is a Outcome_Other, gemcitabine to adjuvant therapy is a Intervention_Pharmacological, lymph node - positive breast cancer is a Participant_Condition	63575_task0	Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Participant_Condition	[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]	No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .	[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]	[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]
efficacy is a Outcome_Other, gemcitabine to adjuvant therapy is a Intervention_Pharmacological, lymph node - positive breast cancer is a Participant_Condition	63575_task1	Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please typing these entity words according to sentence: efficacy, gemcitabine to adjuvant therapy, lymph node - positive breast cancer Options: Outcome_Other, Intervention_Pharmacological, Participant_Condition	[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]	No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .	[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]	[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]
efficacy, gemcitabine to adjuvant therapy, lymph node - positive breast cancer	63575_task2	Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]	No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .	[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]	[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]
Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Schmerzkontrolle is an umlsterm, Hypnose is an umlsterm, Schmerzen is an umlsterm, Schmerzkontrolle is an umlsterm, Techniken is an umlsterm, Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Hypnose is an umlsterm, Techniken is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, Hypnose is an umlsterm	DerSchmerz.80120179.ger.abstr_task0	Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .	[ "Hinsichtlich", "der", "Moeglichkeiten", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "werden", "zunaechst", "relevante", "Untersuchungen", "zur", "hypnotischen", "Schmerzkontrolle", "referiert", ".", "Hierbei", "zeigt", "sich", ",", "dass", "die", "Effektivitaet", "der", "Hypnose", "zur", "Kontrolle", "von", "Schmerzen", "in", "experimentellen", "Untersuchungen", "gut", "nachgewiesen", "ist", ";", "wesentlich", "uneindeutiger", "ist", "die", "Situation", "allerdings", "bei", "den", "entsprechenden", "klinischen", "Studien", ".", "Es", "werden", "3", "grundlegende", "Strategien", "hypnotischer", "Schmerzkontrolle", "dargestellt", ",", "unter", "die", "sich", "die", "verschiedenen", "Techniken", "subsumieren", "lassen", ":", "dissoziative", "assoziative", "und", "symbolische", ".", ",", "Zu", "den", "Grenzen", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "tragen", "verschiedene", "Faktoren", "bei", "wie", "z", ".", "B.", "Hypnose", "als", "Zustand", ",", "Hypnotisierbarkeit", ",", "Rapport", ",", "hypnotische", "Techniken", "und", "Schmerz", "als", "multifaktorieller", "Prozess", ".", "Diese", "Faktoren", "werden", "eroertert", "und", "die", "daraus", "resultierenden", "Kontraindikationen", "aufgezeigt", ".", "Insbesondere", "wird", "auf", "die", "Unterscheidung", "zwischen", "symptom-", "und", "problemorientierter", "Hypnose", "bzw", ".", "Hypnotherapie", "hingewiesen", "." ]	[ "umlsterm" ]
Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Schmerzkontrolle is an umlsterm, Hypnose is an umlsterm, Schmerzen is an umlsterm, Schmerzkontrolle is an umlsterm, Techniken is an umlsterm, Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Hypnose is an umlsterm, Techniken is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, Hypnose is an umlsterm	DerSchmerz.80120179.ger.abstr_task1	Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please typing these entity words according to sentence: Hypnose, Schmerzbehandlung, Schmerzkontrolle, Hypnose, Schmerzen, Schmerzkontrolle, Techniken, Hypnose, Schmerzbehandlung, Hypnose, Techniken, Schmerz, Kontraindikationen, Hypnose Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .	[ "Hinsichtlich", "der", "Moeglichkeiten", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "werden", "zunaechst", "relevante", "Untersuchungen", "zur", "hypnotischen", "Schmerzkontrolle", "referiert", ".", "Hierbei", "zeigt", "sich", ",", "dass", "die", "Effektivitaet", "der", "Hypnose", "zur", "Kontrolle", "von", "Schmerzen", "in", "experimentellen", "Untersuchungen", "gut", "nachgewiesen", "ist", ";", "wesentlich", "uneindeutiger", "ist", "die", "Situation", "allerdings", "bei", "den", "entsprechenden", "klinischen", "Studien", ".", "Es", "werden", "3", "grundlegende", "Strategien", "hypnotischer", "Schmerzkontrolle", "dargestellt", ",", "unter", "die", "sich", "die", "verschiedenen", "Techniken", "subsumieren", "lassen", ":", "dissoziative", "assoziative", "und", "symbolische", ".", ",", "Zu", "den", "Grenzen", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "tragen", "verschiedene", "Faktoren", "bei", "wie", "z", ".", "B.", "Hypnose", "als", "Zustand", ",", "Hypnotisierbarkeit", ",", "Rapport", ",", "hypnotische", "Techniken", "und", "Schmerz", "als", "multifaktorieller", "Prozess", ".", "Diese", "Faktoren", "werden", "eroertert", "und", "die", "daraus", "resultierenden", "Kontraindikationen", "aufgezeigt", ".", "Insbesondere", "wird", "auf", "die", "Unterscheidung", "zwischen", "symptom-", "und", "problemorientierter", "Hypnose", "bzw", ".", "Hypnotherapie", "hingewiesen", "." ]	[ "umlsterm" ]
Hypnose, Schmerzbehandlung, Schmerzkontrolle, Hypnose, Schmerzen, Schmerzkontrolle, Techniken, Hypnose, Schmerzbehandlung, Hypnose, Techniken, Schmerz, Kontraindikationen, Hypnose	DerSchmerz.80120179.ger.abstr_task2	Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .	[ "Hinsichtlich", "der", "Moeglichkeiten", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "werden", "zunaechst", "relevante", "Untersuchungen", "zur", "hypnotischen", "Schmerzkontrolle", "referiert", ".", "Hierbei", "zeigt", "sich", ",", "dass", "die", "Effektivitaet", "der", "Hypnose", "zur", "Kontrolle", "von", "Schmerzen", "in", "experimentellen", "Untersuchungen", "gut", "nachgewiesen", "ist", ";", "wesentlich", "uneindeutiger", "ist", "die", "Situation", "allerdings", "bei", "den", "entsprechenden", "klinischen", "Studien", ".", "Es", "werden", "3", "grundlegende", "Strategien", "hypnotischer", "Schmerzkontrolle", "dargestellt", ",", "unter", "die", "sich", "die", "verschiedenen", "Techniken", "subsumieren", "lassen", ":", "dissoziative", "assoziative", "und", "symbolische", ".", ",", "Zu", "den", "Grenzen", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "tragen", "verschiedene", "Faktoren", "bei", "wie", "z", ".", "B.", "Hypnose", "als", "Zustand", ",", "Hypnotisierbarkeit", ",", "Rapport", ",", "hypnotische", "Techniken", "und", "Schmerz", "als", "multifaktorieller", "Prozess", ".", "Diese", "Faktoren", "werden", "eroertert", "und", "die", "daraus", "resultierenden", "Kontraindikationen", "aufgezeigt", ".", "Insbesondere", "wird", "auf", "die", "Unterscheidung", "zwischen", "symptom-", "und", "problemorientierter", "Hypnose", "bzw", ".", "Hypnotherapie", "hingewiesen", "." ]	[ "umlsterm" ]
NADPH is a compound, CPR is a protein	DS.d1868_task0	Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.	[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]	[ "compound", "protein" ]
NADPH is a compound, CPR is a protein	DS.d1868_task1	Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please typing these entity words according to sentence: NADPH, CPR Options: compound, protein	[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.	[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]	[ "compound", "protein" ]
NADPH, CPR	DS.d1868_task2	Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.	[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]	[ "compound", "protein" ]
findings is an umlsterm, retinal is an umlsterm, patients is an umlsterm, procedures is an umlsterm	DerOpthalmologe.00970353.eng.abstr_task0	Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .	[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]	[ "umlsterm" ]
findings is an umlsterm, retinal is an umlsterm, patients is an umlsterm, procedures is an umlsterm	DerOpthalmologe.00970353.eng.abstr_task1	Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please typing these entity words according to sentence: findings, retinal, patients, procedures Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .	[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]	[ "umlsterm" ]
findings, retinal, patients, procedures	DerOpthalmologe.00970353.eng.abstr_task2	Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .	[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]	[ "umlsterm" ]
Pelvic floor is an umlsterm, Anatomy is an umlsterm, pelvic floor is an umlsterm, physiology is an umlsterm, fascia is an umlsterm, anatomic is an umlsterm, form is an umlsterm, plate is an umlsterm	DerRadiologe.00400429.eng.abstr_task0	Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .	[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]	[ "umlsterm" ]
Pelvic floor is an umlsterm, Anatomy is an umlsterm, pelvic floor is an umlsterm, physiology is an umlsterm, fascia is an umlsterm, anatomic is an umlsterm, form is an umlsterm, plate is an umlsterm	DerRadiologe.00400429.eng.abstr_task1	Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please typing these entity words according to sentence: Pelvic floor, Anatomy, pelvic floor, physiology, fascia, anatomic, form, plate Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .	[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]	[ "umlsterm" ]
Pelvic floor, Anatomy, pelvic floor, physiology, fascia, anatomic, form, plate	DerRadiologe.00400429.eng.abstr_task2	Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .	[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]	[ "umlsterm" ]
Met326Ile is a ProteinMutation	1283_task0	Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation	[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]	Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.	[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]	[ "ProteinMutation" ]
Met326Ile is a ProteinMutation	1283_task1	Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please typing these entity words according to sentence: Met326Ile Options: ProteinMutation	[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]	Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.	[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]	[ "ProteinMutation" ]
Met326Ile	1283_task2	Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]	Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.	[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]	[ "ProteinMutation" ]
Keratoakanthom is an umlsterm, Therapie is an umlsterm, Methotrexat is an umlsterm, Tumorregression is an umlsterm, Therapie is an umlsterm, Tumoren is an umlsterm	DerHautarzt.00510612.ger.abstr_task0	Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .	[ "Eine", "53", "Jahre", "alte", "Patientin", "entwickelte", "ueber", "2", "Monate", "ein", "Keratoakanthom", "am", "linken", "Nasenfluegel", ".", "Nach", "wiederholten", "erfolglosen", "kryotherapeutischen", "Behandlungsversuchen", "erfolgten", "zweimal", "im", "Abstand", "von", "7", "Tagen", "intralaesionale", "Methothrexat", "-", "Injektionen", ",", "wonach", "es", "innerhalb", "von", "5", "Wochen", "zu", "einer", "vollstaendigen", "Abheilung", "kam", ".", "Obwohl", "kontrollierte", "Studien", "ueber", "die", "Therapie", "von", "Keratoakanthomen", "mit", "Methotrexat", "bislang", "fehlen", ",", "legt", "die", "schnelle", "Tumorregression", "und", "das", "gute", "kosmetische", "Ergebnis", "diese", "Art", "der", "Therapie", "bei", "operationstechnisch", "schwierig", "lokalisierten", "Tumoren", "nahe", "." ]	[ "umlsterm" ]
Keratoakanthom is an umlsterm, Therapie is an umlsterm, Methotrexat is an umlsterm, Tumorregression is an umlsterm, Therapie is an umlsterm, Tumoren is an umlsterm	DerHautarzt.00510612.ger.abstr_task1	Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please typing these entity words according to sentence: Keratoakanthom, Therapie, Methotrexat, Tumorregression, Therapie, Tumoren Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .	[ "Eine", "53", "Jahre", "alte", "Patientin", "entwickelte", "ueber", "2", "Monate", "ein", "Keratoakanthom", "am", "linken", "Nasenfluegel", ".", "Nach", "wiederholten", "erfolglosen", "kryotherapeutischen", "Behandlungsversuchen", "erfolgten", "zweimal", "im", "Abstand", "von", "7", "Tagen", "intralaesionale", "Methothrexat", "-", "Injektionen", ",", "wonach", "es", "innerhalb", "von", "5", "Wochen", "zu", "einer", "vollstaendigen", "Abheilung", "kam", ".", "Obwohl", "kontrollierte", "Studien", "ueber", "die", "Therapie", "von", "Keratoakanthomen", "mit", "Methotrexat", "bislang", "fehlen", ",", "legt", "die", "schnelle", "Tumorregression", "und", "das", "gute", "kosmetische", "Ergebnis", "diese", "Art", "der", "Therapie", "bei", "operationstechnisch", "schwierig", "lokalisierten", "Tumoren", "nahe", "." ]	[ "umlsterm" ]
Keratoakanthom, Therapie, Methotrexat, Tumorregression, Therapie, Tumoren	DerHautarzt.00510612.ger.abstr_task2	Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .	[ "Eine", "53", "Jahre", "alte", "Patientin", "entwickelte", "ueber", "2", "Monate", "ein", "Keratoakanthom", "am", "linken", "Nasenfluegel", ".", "Nach", "wiederholten", "erfolglosen", "kryotherapeutischen", "Behandlungsversuchen", "erfolgten", "zweimal", "im", "Abstand", "von", "7", "Tagen", "intralaesionale", "Methothrexat", "-", "Injektionen", ",", "wonach", "es", "innerhalb", "von", "5", "Wochen", "zu", "einer", "vollstaendigen", "Abheilung", "kam", ".", "Obwohl", "kontrollierte", "Studien", "ueber", "die", "Therapie", "von", "Keratoakanthomen", "mit", "Methotrexat", "bislang", "fehlen", ",", "legt", "die", "schnelle", "Tumorregression", "und", "das", "gute", "kosmetische", "Ergebnis", "diese", "Art", "der", "Therapie", "bei", "operationstechnisch", "schwierig", "lokalisierten", "Tumoren", "nahe", "." ]	[ "umlsterm" ]
paroxetine is a compound, SERT is a protein	DS.d349_task0	Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]	The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.	[ "The", "equality", "of", "K", "(", "D", ")", "of", "paroxetine", "binding", "to", "blood", "platelet", "membranes", "and", "to", "membranes", "from", "nerve", "endings", "appears", "to", "encourage", "the", "use", "of", "such", "membranes", "as", "a", "model", "for", "brain", "SERT", "." ]	[ "compound", "protein" ]
paroxetine is a compound, SERT is a protein	DS.d349_task1	Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please typing these entity words according to sentence: paroxetine, SERT Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]	The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.	[ "The", "equality", "of", "K", "(", "D", ")", "of", "paroxetine", "binding", "to", "blood", "platelet", "membranes", "and", "to", "membranes", "from", "nerve", "endings", "appears", "to", "encourage", "the", "use", "of", "such", "membranes", "as", "a", "model", "for", "brain", "SERT", "." ]	[ "compound", "protein" ]
paroxetine, SERT	DS.d349_task2	Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]	The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.	[ "The", "equality", "of", "K", "(", "D", ")", "of", "paroxetine", "binding", "to", "blood", "platelet", "membranes", "and", "to", "membranes", "from", "nerve", "endings", "appears", "to", "encourage", "the", "use", "of", "such", "membranes", "as", "a", "model", "for", "brain", "SERT", "." ]	[ "compound", "protein" ]
Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, Hirnbiopsie is an umlsterm, Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, Gliomatosis cerebri is an umlsterm, Tumorzellen is an umlsterm, Diagnosefindung is an umlsterm, Kontrastmittelaufnahme is an umlsterm, Drucksteigerung is an umlsterm, Differentialdiagnosen is an umlsterm, Literatur is an umlsterm	DerNervenarzt.00710481.ger.abstr_task0	Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .	[ "Die", "Diagnose", "der", "seltenen", "Gliomatosis", "cerebri", "kann", "nur", "in", "Zusammenschau", "von", "klinischen", ",", "radiologischen", "und", "histopathologischen", "Befunden", "gestellt", "werden", ".", "Im", "vorliegenden", "Artikel", "berichten", "wir", "ueber", "2", "Patienten", ",", "bei", "denen", "intra", "vitam", "nach", "stereotaktischer", "Hirnbiopsie", "die", "Diagnose", "Gliomatosis", "cerebri", "gesichert", "wurde", ".", "Da", "in", "beiden", "Faellen", "fuer", "Gliomatosis", "cerebri", "ungewoehnlich", "hochgradig", "entdifferenzierte", "Tumorzellen", "vorlagen", ",", "wurde", "die", "Diagnosefindung", "durch", "atypische", "Befunde", "wie", "Kontrastmittelaufnahme", "im", "MRT", "und", "klinische", "Zeichen", "der", "intrakraniellen", "Drucksteigerung", "erschwert", ".", "Klinischer", "Verlauf", ",", "Differentialdiagnosen", "und", "Literatur", "werden", "kurz", "dargestellt", "." ]	[ "umlsterm" ]
Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, Hirnbiopsie is an umlsterm, Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, Gliomatosis cerebri is an umlsterm, Tumorzellen is an umlsterm, Diagnosefindung is an umlsterm, Kontrastmittelaufnahme is an umlsterm, Drucksteigerung is an umlsterm, Differentialdiagnosen is an umlsterm, Literatur is an umlsterm	DerNervenarzt.00710481.ger.abstr_task1	Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please typing these entity words according to sentence: Diagnose, Gliomatosis cerebri, radiologischen, Patienten, Hirnbiopsie, Diagnose, Gliomatosis cerebri, Gliomatosis cerebri, Tumorzellen, Diagnosefindung, Kontrastmittelaufnahme, Drucksteigerung, Differentialdiagnosen, Literatur Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .	[ "Die", "Diagnose", "der", "seltenen", "Gliomatosis", "cerebri", "kann", "nur", "in", "Zusammenschau", "von", "klinischen", ",", "radiologischen", "und", "histopathologischen", "Befunden", "gestellt", "werden", ".", "Im", "vorliegenden", "Artikel", "berichten", "wir", "ueber", "2", "Patienten", ",", "bei", "denen", "intra", "vitam", "nach", "stereotaktischer", "Hirnbiopsie", "die", "Diagnose", "Gliomatosis", "cerebri", "gesichert", "wurde", ".", "Da", "in", "beiden", "Faellen", "fuer", "Gliomatosis", "cerebri", "ungewoehnlich", "hochgradig", "entdifferenzierte", "Tumorzellen", "vorlagen", ",", "wurde", "die", "Diagnosefindung", "durch", "atypische", "Befunde", "wie", "Kontrastmittelaufnahme", "im", "MRT", "und", "klinische", "Zeichen", "der", "intrakraniellen", "Drucksteigerung", "erschwert", ".", "Klinischer", "Verlauf", ",", "Differentialdiagnosen", "und", "Literatur", "werden", "kurz", "dargestellt", "." ]	[ "umlsterm" ]
Diagnose, Gliomatosis cerebri, radiologischen, Patienten, Hirnbiopsie, Diagnose, Gliomatosis cerebri, Gliomatosis cerebri, Tumorzellen, Diagnosefindung, Kontrastmittelaufnahme, Drucksteigerung, Differentialdiagnosen, Literatur	DerNervenarzt.00710481.ger.abstr_task2	Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .	[ "Die", "Diagnose", "der", "seltenen", "Gliomatosis", "cerebri", "kann", "nur", "in", "Zusammenschau", "von", "klinischen", ",", "radiologischen", "und", "histopathologischen", "Befunden", "gestellt", "werden", ".", "Im", "vorliegenden", "Artikel", "berichten", "wir", "ueber", "2", "Patienten", ",", "bei", "denen", "intra", "vitam", "nach", "stereotaktischer", "Hirnbiopsie", "die", "Diagnose", "Gliomatosis", "cerebri", "gesichert", "wurde", ".", "Da", "in", "beiden", "Faellen", "fuer", "Gliomatosis", "cerebri", "ungewoehnlich", "hochgradig", "entdifferenzierte", "Tumorzellen", "vorlagen", ",", "wurde", "die", "Diagnosefindung", "durch", "atypische", "Befunde", "wie", "Kontrastmittelaufnahme", "im", "MRT", "und", "klinische", "Zeichen", "der", "intrakraniellen", "Drucksteigerung", "erschwert", ".", "Klinischer", "Verlauf", ",", "Differentialdiagnosen", "und", "Literatur", "werden", "kurz", "dargestellt", "." ]	[ "umlsterm" ]
MAD3 is a Protein, I kappa B alpha is a Protein, MAD3 is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein	378_task0	Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "N-", "and", "C", "-", "terminal", "sequences", "control", "degradation", "of", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ".", "\n", "The", "proteolytic", "degradation", "of", "the", "inhibitory", "protein", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "extracellular", "stimulation", "is", "a", "prerequisite", "step", "in", "the", "activation", "of", "the", "transcription", "factor", "NF", "-", "kappa", "B.", "Analysis", "of", "the", "expression", "of", "human", "I", "kappa", "B", "alpha", "protein", "in", "stable", "transfectants", "of", "mouse", "70Z/3", "cells", "shows", "that", ",", "as", "for", "the", "endogenous", "murine", "protein", ",", "exogenous", "I", "kappa", "B", "alpha", "is", "degraded", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ",", "such", "as", "phorbol", "myristate", "acetate", "or", "lipopolysaccharide", ".", "In", "addition", ",", "pretreatment", "of", "the", "cells", "with", "the", "proteasome", "inhibitor", "N", "-", "Ac", "-", "Leu", "-", "Leu", "-", "norleucinal", "inhibits", "this", "ligand", "-", "induced", "degradation", "and", ",", "in", "agreement", "with", "previous", "studies", ",", "stabilizes", "a", "hyperphosphorylated", "form", "of", "the", "human", "I", "kappa", "B", "alpha", "protein", ".", "By", "expressing", "mutant", "forms", "of", "the", "human", "protein", "in", "this", "cell", "line", ",", "we", "have", "been", "able", "to", "delineate", "the", "sequences", "responsible", "for", "both", "the", "ligand", "-", "induced", "phosphorylation", "and", "the", "degradation", "of", "I", "kappa", "B", "alpha", ".", "Our", "results", "show", "that", "deletion", "of", "the", "C", "terminus", "of", "the", "I", "kappa", "B", "alpha", "molecule", "up", "to", "amino", "acid", "279", "abolishes", "constitutive", "but", "not", "ligand", "-", "inducible", "phosphorylation", "and", "inhibits", "ligand", "-", "inducible", "degradation", ".", "Further", "analysis", "reveals", "that", "the", "inducible", "phosphorylation", "of", "I", "kappa", "B", "alpha", "maps", "to", "two", "serines", "in", "the", "N", "terminus", "of", "the", "protein", "(", "residues", "32", "and", "36", ")", "and", "that", "the", "mutation", "of", "either", "residue", "is", "sufficient", "to", "abolish", "ligand", "-", "induced", "degradation", ",", "whereas", "both", "residues", "must", "be", "mutated", "to", "abolish", "inducible", "phosphorylation", "of", "the", "protein", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
MAD3 is a Protein, I kappa B alpha is a Protein, MAD3 is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein	378_task1	Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: MAD3, I kappa B alpha, MAD3, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "N-", "and", "C", "-", "terminal", "sequences", "control", "degradation", "of", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ".", "\n", "The", "proteolytic", "degradation", "of", "the", "inhibitory", "protein", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "extracellular", "stimulation", "is", "a", "prerequisite", "step", "in", "the", "activation", "of", "the", "transcription", "factor", "NF", "-", "kappa", "B.", "Analysis", "of", "the", "expression", "of", "human", "I", "kappa", "B", "alpha", "protein", "in", "stable", "transfectants", "of", "mouse", "70Z/3", "cells", "shows", "that", ",", "as", "for", "the", "endogenous", "murine", "protein", ",", "exogenous", "I", "kappa", "B", "alpha", "is", "degraded", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ",", "such", "as", "phorbol", "myristate", "acetate", "or", "lipopolysaccharide", ".", "In", "addition", ",", "pretreatment", "of", "the", "cells", "with", "the", "proteasome", "inhibitor", "N", "-", "Ac", "-", "Leu", "-", "Leu", "-", "norleucinal", "inhibits", "this", "ligand", "-", "induced", "degradation", "and", ",", "in", "agreement", "with", "previous", "studies", ",", "stabilizes", "a", "hyperphosphorylated", "form", "of", "the", "human", "I", "kappa", "B", "alpha", "protein", ".", "By", "expressing", "mutant", "forms", "of", "the", "human", "protein", "in", "this", "cell", "line", ",", "we", "have", "been", "able", "to", "delineate", "the", "sequences", "responsible", "for", "both", "the", "ligand", "-", "induced", "phosphorylation", "and", "the", "degradation", "of", "I", "kappa", "B", "alpha", ".", "Our", "results", "show", "that", "deletion", "of", "the", "C", "terminus", "of", "the", "I", "kappa", "B", "alpha", "molecule", "up", "to", "amino", "acid", "279", "abolishes", "constitutive", "but", "not", "ligand", "-", "inducible", "phosphorylation", "and", "inhibits", "ligand", "-", "inducible", "degradation", ".", "Further", "analysis", "reveals", "that", "the", "inducible", "phosphorylation", "of", "I", "kappa", "B", "alpha", "maps", "to", "two", "serines", "in", "the", "N", "terminus", "of", "the", "protein", "(", "residues", "32", "and", "36", ")", "and", "that", "the", "mutation", "of", "either", "residue", "is", "sufficient", "to", "abolish", "ligand", "-", "induced", "degradation", ",", "whereas", "both", "residues", "must", "be", "mutated", "to", "abolish", "inducible", "phosphorylation", "of", "the", "protein", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
MAD3, I kappa B alpha, MAD3, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha	378_task2	Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)	[ "N-", "and", "C", "-", "terminal", "sequences", "control", "degradation", "of", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ".", "\n", "The", "proteolytic", "degradation", "of", "the", "inhibitory", "protein", "MAD3", "/", "I", "kappa", "B", "alpha", "in", "response", "to", "extracellular", "stimulation", "is", "a", "prerequisite", "step", "in", "the", "activation", "of", "the", "transcription", "factor", "NF", "-", "kappa", "B.", "Analysis", "of", "the", "expression", "of", "human", "I", "kappa", "B", "alpha", "protein", "in", "stable", "transfectants", "of", "mouse", "70Z/3", "cells", "shows", "that", ",", "as", "for", "the", "endogenous", "murine", "protein", ",", "exogenous", "I", "kappa", "B", "alpha", "is", "degraded", "in", "response", "to", "inducers", "of", "NF", "-", "kappa", "B", "activity", ",", "such", "as", "phorbol", "myristate", "acetate", "or", "lipopolysaccharide", ".", "In", "addition", ",", "pretreatment", "of", "the", "cells", "with", "the", "proteasome", "inhibitor", "N", "-", "Ac", "-", "Leu", "-", "Leu", "-", "norleucinal", "inhibits", "this", "ligand", "-", "induced", "degradation", "and", ",", "in", "agreement", "with", "previous", "studies", ",", "stabilizes", "a", "hyperphosphorylated", "form", "of", "the", "human", "I", "kappa", "B", "alpha", "protein", ".", "By", "expressing", "mutant", "forms", "of", "the", "human", "protein", "in", "this", "cell", "line", ",", "we", "have", "been", "able", "to", "delineate", "the", "sequences", "responsible", "for", "both", "the", "ligand", "-", "induced", "phosphorylation", "and", "the", "degradation", "of", "I", "kappa", "B", "alpha", ".", "Our", "results", "show", "that", "deletion", "of", "the", "C", "terminus", "of", "the", "I", "kappa", "B", "alpha", "molecule", "up", "to", "amino", "acid", "279", "abolishes", "constitutive", "but", "not", "ligand", "-", "inducible", "phosphorylation", "and", "inhibits", "ligand", "-", "inducible", "degradation", ".", "Further", "analysis", "reveals", "that", "the", "inducible", "phosphorylation", "of", "I", "kappa", "B", "alpha", "maps", "to", "two", "serines", "in", "the", "N", "terminus", "of", "the", "protein", "(", "residues", "32", "and", "36", ")", "and", "that", "the", "mutation", "of", "either", "residue", "is", "sufficient", "to", "abolish", "ligand", "-", "induced", "degradation", ",", "whereas", "both", "residues", "must", "be", "mutated", "to", "abolish", "inducible", "phosphorylation", "of", "the", "protein", ".", "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "Protein" ]
Lovenox is a BRAND, anticoagulants is a GROUP, platelet inhibitors is a GROUP, acetylsalicylic acid is a DRUG, NSAIDs is a GROUP, ketorolac tromethamine is a DRUG, dipyridamole is a DRUG, sulfinpyrazone is a DRUG	Enoxaparin_ddi_task0	Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG, BRAND	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .	[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]	[ "DRUG", "GROUP", "BRAND" ]
Lovenox is a BRAND, anticoagulants is a GROUP, platelet inhibitors is a GROUP, acetylsalicylic acid is a DRUG, NSAIDs is a GROUP, ketorolac tromethamine is a DRUG, dipyridamole is a DRUG, sulfinpyrazone is a DRUG	Enoxaparin_ddi_task1	Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please typing these entity words according to sentence: Lovenox, anticoagulants, platelet inhibitors, acetylsalicylic acid, NSAIDs, ketorolac tromethamine, dipyridamole, sulfinpyrazone Options: GROUP, DRUG, BRAND	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .	[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]	[ "DRUG", "GROUP", "BRAND" ]
Lovenox, anticoagulants, platelet inhibitors, acetylsalicylic acid, NSAIDs, ketorolac tromethamine, dipyridamole, sulfinpyrazone	Enoxaparin_ddi_task2	Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .	[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]	[ "DRUG", "GROUP", "BRAND" ]
U2 snRNP is a RNA, SF3a is a protein-complex, SF3b is a protein-complex, U2 snRNP is a RNA, pre - mRNAs is a RNA	1.0alpha7.train.862_task0	Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: RNA, protein-complex	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]	Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).	[ "Fractionation", "of", "splicing", "extracts", "showed", "that", "two", "fractions", "associated", "with", " ", "U2", "snRNP", ",", " ", "SF3a", "and", " ", "SF3b", ",", "are", "required", "for", "the", "binding", "of", " ", "U2", "snRNP", "to", " ", "pre", "-", "mRNAs", "(", "10", ",", " ", "31", ")", "." ]	[ "RNA", "protein-complex" ]
U2 snRNP is a RNA, SF3a is a protein-complex, SF3b is a protein-complex, U2 snRNP is a RNA, pre - mRNAs is a RNA	1.0alpha7.train.862_task1	Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please typing these entity words according to sentence: U2 snRNP, SF3a, SF3b, U2 snRNP, pre - mRNAs Options: RNA, protein-complex	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]	Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).	[ "Fractionation", "of", "splicing", "extracts", "showed", "that", "two", "fractions", "associated", "with", " ", "U2", "snRNP", ",", " ", "SF3a", "and", " ", "SF3b", ",", "are", "required", "for", "the", "binding", "of", " ", "U2", "snRNP", "to", " ", "pre", "-", "mRNAs", "(", "10", ",", " ", "31", ")", "." ]	[ "RNA", "protein-complex" ]
U2 snRNP, SF3a, SF3b, U2 snRNP, pre - mRNAs	1.0alpha7.train.862_task2	Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]	Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).	[ "Fractionation", "of", "splicing", "extracts", "showed", "that", "two", "fractions", "associated", "with", " ", "U2", "snRNP", ",", " ", "SF3a", "and", " ", "SF3b", ",", "are", "required", "for", "the", "binding", "of", " ", "U2", "snRNP", "to", " ", "pre", "-", "mRNAs", "(", "10", ",", " ", "31", ")", "." ]	[ "RNA", "protein-complex" ]
Runx3 is a Protein, Runx3 is a Protein, Eomes is a Protein, T - bet is a Protein, perforin is a Protein, CD8 is a Protein, beta - Actin is a Protein, Prf1 is a Protein, CD8 is a Protein, beta - Actin is a Protein, granzyme B is a Protein, IFN - gamma is a Protein, TNF is a Protein, IL-2 is a Protein, CD8 is a Protein, granzyme B is a Protein, Runx3 is a Protein, Eomes is a Protein, Prf1 is a Protein, CD8 is a Protein, Prf1 is a Protein, Runx3 is a Protein, Eomes is a Protein	218_task0	Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O" ]	Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.	[ "Key", "role", "for", "Runx3", "in", "effector", "CTL", "differentiation", ".", "(", "A", ")", "Western", "analysis", "of", "Runx3", ",", "Eomes", ",", "T", "-", "bet", ",", "and", "perforin", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "B", ")", "Northern", "blot", "analysis", "of", "Prf1", "mRNA", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "C", ")", "Expression", "of", "granzyme", "B", ",", "IFN", "-", "gamma", ",", "TNF", ",", "and", "IL-2", "by", "resting", "or", "restimulated", "(", "6", "h", ")", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "The", "vertical", "gray", "line", "indicates", "the", "granzyme", "B", "MFI", "for", "WT", "GFP+", "cells", ".", "Results", "in", "A", "-", "C", "are", "representative", "of", "two", "independent", "experiments", ".", "(", "D", ")", "ChIP", "analysis", "of", "binding", "of", "endogenous", "Runx3", "and", "Eomes", "to", "the", "Prf1", "locus", ".", "Enrichment", "of", "the", "indicated", "genomic", "regions", "was", "evaluated", "by", "real", "-", "time", "PCR", "of", "DNA", "from", "immunoprecipitated", "and", "input", "chromatin", ".", "The", "data", "are", "the", "means", "of", "duplicate", "measurements", "from", "two", "chromatin", "preparations", "from", "two", "independent", "CD8", "+", "T", "cell", "differentiations", ".", "The", "efficiency", "of", "recovery", "of", "input", "for", "the", "-1-kb", "region", "of", "Prf1", "was", "0.97", "%", "for", "the", "Runx3", "ChIP", "and", "0.5", "%", "for", "the", "Eomes", "ChIP", "." ]	[ "Protein" ]
Runx3 is a Protein, Runx3 is a Protein, Eomes is a Protein, T - bet is a Protein, perforin is a Protein, CD8 is a Protein, beta - Actin is a Protein, Prf1 is a Protein, CD8 is a Protein, beta - Actin is a Protein, granzyme B is a Protein, IFN - gamma is a Protein, TNF is a Protein, IL-2 is a Protein, CD8 is a Protein, granzyme B is a Protein, Runx3 is a Protein, Eomes is a Protein, Prf1 is a Protein, CD8 is a Protein, Prf1 is a Protein, Runx3 is a Protein, Eomes is a Protein	218_task1	Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please typing these entity words according to sentence: Runx3, Runx3, Eomes, T - bet, perforin, CD8, beta - Actin, Prf1, CD8, beta - Actin, granzyme B, IFN - gamma, TNF, IL-2, CD8, granzyme B, Runx3, Eomes, Prf1, CD8, Prf1, Runx3, Eomes Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O" ]	Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.	[ "Key", "role", "for", "Runx3", "in", "effector", "CTL", "differentiation", ".", "(", "A", ")", "Western", "analysis", "of", "Runx3", ",", "Eomes", ",", "T", "-", "bet", ",", "and", "perforin", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "B", ")", "Northern", "blot", "analysis", "of", "Prf1", "mRNA", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "C", ")", "Expression", "of", "granzyme", "B", ",", "IFN", "-", "gamma", ",", "TNF", ",", "and", "IL-2", "by", "resting", "or", "restimulated", "(", "6", "h", ")", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "The", "vertical", "gray", "line", "indicates", "the", "granzyme", "B", "MFI", "for", "WT", "GFP+", "cells", ".", "Results", "in", "A", "-", "C", "are", "representative", "of", "two", "independent", "experiments", ".", "(", "D", ")", "ChIP", "analysis", "of", "binding", "of", "endogenous", "Runx3", "and", "Eomes", "to", "the", "Prf1", "locus", ".", "Enrichment", "of", "the", "indicated", "genomic", "regions", "was", "evaluated", "by", "real", "-", "time", "PCR", "of", "DNA", "from", "immunoprecipitated", "and", "input", "chromatin", ".", "The", "data", "are", "the", "means", "of", "duplicate", "measurements", "from", "two", "chromatin", "preparations", "from", "two", "independent", "CD8", "+", "T", "cell", "differentiations", ".", "The", "efficiency", "of", "recovery", "of", "input", "for", "the", "-1-kb", "region", "of", "Prf1", "was", "0.97", "%", "for", "the", "Runx3", "ChIP", "and", "0.5", "%", "for", "the", "Eomes", "ChIP", "." ]	[ "Protein" ]
Runx3, Runx3, Eomes, T - bet, perforin, CD8, beta - Actin, Prf1, CD8, beta - Actin, granzyme B, IFN - gamma, TNF, IL-2, CD8, granzyme B, Runx3, Eomes, Prf1, CD8, Prf1, Runx3, Eomes	218_task2	Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O" ]	Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.	[ "Key", "role", "for", "Runx3", "in", "effector", "CTL", "differentiation", ".", "(", "A", ")", "Western", "analysis", "of", "Runx3", ",", "Eomes", ",", "T", "-", "bet", ",", "and", "perforin", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "B", ")", "Northern", "blot", "analysis", "of", "Prf1", "mRNA", "expression", "in", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "T", "cells", "differentiated", "for", "6", "d.", "beta", "-", "Actin", "was", "used", "as", "a", "loading", "control", ".", "(", "C", ")", "Expression", "of", "granzyme", "B", ",", "IFN", "-", "gamma", ",", "TNF", ",", "and", "IL-2", "by", "resting", "or", "restimulated", "(", "6", "h", ")", "Runx3+/+", "versus", "Runx3-/-", "CD8", "+", "SP", "T", "cells", "differentiated", "for", "6", "d.", "The", "vertical", "gray", "line", "indicates", "the", "granzyme", "B", "MFI", "for", "WT", "GFP+", "cells", ".", "Results", "in", "A", "-", "C", "are", "representative", "of", "two", "independent", "experiments", ".", "(", "D", ")", "ChIP", "analysis", "of", "binding", "of", "endogenous", "Runx3", "and", "Eomes", "to", "the", "Prf1", "locus", ".", "Enrichment", "of", "the", "indicated", "genomic", "regions", "was", "evaluated", "by", "real", "-", "time", "PCR", "of", "DNA", "from", "immunoprecipitated", "and", "input", "chromatin", ".", "The", "data", "are", "the", "means", "of", "duplicate", "measurements", "from", "two", "chromatin", "preparations", "from", "two", "independent", "CD8", "+", "T", "cell", "differentiations", ".", "The", "efficiency", "of", "recovery", "of", "input", "for", "the", "-1-kb", "region", "of", "Prf1", "was", "0.97", "%", "for", "the", "Runx3", "ChIP", "and", "0.5", "%", "for", "the", "Eomes", "ChIP", "." ]	[ "Protein" ]
Death is an umlsterm, taboos is an umlsterm, society is an umlsterm, medicine is an umlsterm, cause is an umlsterm, uncertainty is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, dying patients is an umlsterm, method is an umlsterm, trauma is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, voluntary helpers is an umlsterm, resonance is an umlsterm, elements is an umlsterm, sensitivity is an umlsterm, mood is an umlsterm, fantasy is an umlsterm, method is an umlsterm, treatment is an umlsterm, supervision is an umlsterm	Psychotherapeut.70420028.eng.abstr_task0	Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .	[ "Death", "and", "dying", "are", "taboos", "in", "society", "as", "well", "as", "in", "medicine", ".", "Mourning", ",", "despair", ",", "depressive", "crisis", "and", "infantile", "protest", "cause", "uncertainty", "in", "relatives", ",", "doctors", "and", "nurses", ".", "Therefore", ",", "dying", "patients", "are", "left", "alone", ",", "sometimes", "under", "inhumane", "conditions", "and", "without", "dignity", ".", "A", "specific", "method", "is", "described", "which", "allows", "defocussing", "the", "trauma", "of", "dying", "and", "unblocking", "the", "communications", "with", "relatives", ",", "doctors", ",", "nurses", "and", "voluntary", "helpers", ".", "The", "process", "of", "resonance", "with", "its", "elements", "of", "sensitivity", ",", "mood", "and", "fantasy", "is", "the", "centre", "of", "this", "method", "for", "treatment", "and", "supervision", "." ]	[ "umlsterm" ]
Death is an umlsterm, taboos is an umlsterm, society is an umlsterm, medicine is an umlsterm, cause is an umlsterm, uncertainty is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, dying patients is an umlsterm, method is an umlsterm, trauma is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, voluntary helpers is an umlsterm, resonance is an umlsterm, elements is an umlsterm, sensitivity is an umlsterm, mood is an umlsterm, fantasy is an umlsterm, method is an umlsterm, treatment is an umlsterm, supervision is an umlsterm	Psychotherapeut.70420028.eng.abstr_task1	Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please typing these entity words according to sentence: Death, taboos, society, medicine, cause, uncertainty, relatives, doctors, nurses, dying patients, method, trauma, relatives, doctors, nurses, voluntary helpers, resonance, elements, sensitivity, mood, fantasy, method, treatment, supervision Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .	[ "Death", "and", "dying", "are", "taboos", "in", "society", "as", "well", "as", "in", "medicine", ".", "Mourning", ",", "despair", ",", "depressive", "crisis", "and", "infantile", "protest", "cause", "uncertainty", "in", "relatives", ",", "doctors", "and", "nurses", ".", "Therefore", ",", "dying", "patients", "are", "left", "alone", ",", "sometimes", "under", "inhumane", "conditions", "and", "without", "dignity", ".", "A", "specific", "method", "is", "described", "which", "allows", "defocussing", "the", "trauma", "of", "dying", "and", "unblocking", "the", "communications", "with", "relatives", ",", "doctors", ",", "nurses", "and", "voluntary", "helpers", ".", "The", "process", "of", "resonance", "with", "its", "elements", "of", "sensitivity", ",", "mood", "and", "fantasy", "is", "the", "centre", "of", "this", "method", "for", "treatment", "and", "supervision", "." ]	[ "umlsterm" ]
Death, taboos, society, medicine, cause, uncertainty, relatives, doctors, nurses, dying patients, method, trauma, relatives, doctors, nurses, voluntary helpers, resonance, elements, sensitivity, mood, fantasy, method, treatment, supervision	Psychotherapeut.70420028.eng.abstr_task2	Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .	[ "Death", "and", "dying", "are", "taboos", "in", "society", "as", "well", "as", "in", "medicine", ".", "Mourning", ",", "despair", ",", "depressive", "crisis", "and", "infantile", "protest", "cause", "uncertainty", "in", "relatives", ",", "doctors", "and", "nurses", ".", "Therefore", ",", "dying", "patients", "are", "left", "alone", ",", "sometimes", "under", "inhumane", "conditions", "and", "without", "dignity", ".", "A", "specific", "method", "is", "described", "which", "allows", "defocussing", "the", "trauma", "of", "dying", "and", "unblocking", "the", "communications", "with", "relatives", ",", "doctors", ",", "nurses", "and", "voluntary", "helpers", ".", "The", "process", "of", "resonance", "with", "its", "elements", "of", "sensitivity", ",", "mood", "and", "fantasy", "is", "the", "centre", "of", "this", "method", "for", "treatment", "and", "supervision", "." ]	[ "umlsterm" ]
Previous is a Temporal, antispastic drugs is a Drug, Contraindication is a Condition, baclofen or toxin is a Scope, Antecedent is a Temporal, epileptic seizure is a Condition, Psychiatric is a Condition, antecedent is a Temporal	NCT02462317_exc_task0	Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Temporal, Condition, Drug	[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]	Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent	[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]	[ "Drug", "Scope", "Condition", "Temporal" ]
Previous is a Temporal, antispastic drugs is a Drug, Contraindication is a Condition, baclofen or toxin is a Scope, Antecedent is a Temporal, epileptic seizure is a Condition, Psychiatric is a Condition, antecedent is a Temporal	NCT02462317_exc_task1	Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please typing these entity words according to sentence: Previous, antispastic drugs, Contraindication, baclofen or toxin, Antecedent, epileptic seizure, Psychiatric, antecedent Options: Scope, Temporal, Condition, Drug	[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]	Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent	[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]	[ "Drug", "Scope", "Condition", "Temporal" ]
Previous, antispastic drugs, Contraindication, baclofen or toxin, Antecedent, epileptic seizure, Psychiatric, antecedent	NCT02462317_exc_task2	Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please extract entity words from the input sentence	[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]	Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent	[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]	[ "Drug", "Scope", "Condition", "Temporal" ]
tumor is an umlsterm, surgery is an umlsterm, face is an umlsterm, defects is an umlsterm, retrospective study is an umlsterm, patients is an umlsterm, implants is an umlsterm, mastoid is an umlsterm, implants is an umlsterm, dental implants is an umlsterm, survival is an umlsterm	MundKieferGesichtschirurgie.9003s130.eng.abstr_task0	Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .	[ "Endosteal", "implants", "after", "tumor", "surgery", "of", "the", "face", "are", "helpful", "in", "reconstructing", "facial", "defects", ".", "A", "retrospective", "study", "of", "our", "patients", "treated", "using", "craniofacial", "implants", "was", "conducted", "to", "evaluate", "long", "-", "term", "results", ".", "A", "total", "of", "128", "implants", "were", "inserted", ",", "110", "implants", "in", "the", "periorbital", ",", "12", "implants", "in", "the", "mastoid", ",", "and", "six", "implants", "in", "the", "paranasal", "region", ";", "113", "implants", "were", "short", "craniofacial", "Brånemark", "implants", ",", "and", "15", "implants", "were", "dental", "implants", ".", "The", "success", "rate", "for", "implant", "survival", "was", "94.5", "%", ".", "Long", "-", "term", "results", "were", "promising", "and", "more", "than", "satisfactory", ",", "leading", "to", "a", "large", "indication", "for", "these", "endosteal", "implants", "." ]	[ "umlsterm" ]
tumor is an umlsterm, surgery is an umlsterm, face is an umlsterm, defects is an umlsterm, retrospective study is an umlsterm, patients is an umlsterm, implants is an umlsterm, mastoid is an umlsterm, implants is an umlsterm, dental implants is an umlsterm, survival is an umlsterm	MundKieferGesichtschirurgie.9003s130.eng.abstr_task1	Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please typing these entity words according to sentence: tumor, surgery, face, defects, retrospective study, patients, implants, mastoid, implants, dental implants, survival Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .	[ "Endosteal", "implants", "after", "tumor", "surgery", "of", "the", "face", "are", "helpful", "in", "reconstructing", "facial", "defects", ".", "A", "retrospective", "study", "of", "our", "patients", "treated", "using", "craniofacial", "implants", "was", "conducted", "to", "evaluate", "long", "-", "term", "results", ".", "A", "total", "of", "128", "implants", "were", "inserted", ",", "110", "implants", "in", "the", "periorbital", ",", "12", "implants", "in", "the", "mastoid", ",", "and", "six", "implants", "in", "the", "paranasal", "region", ";", "113", "implants", "were", "short", "craniofacial", "Brånemark", "implants", ",", "and", "15", "implants", "were", "dental", "implants", ".", "The", "success", "rate", "for", "implant", "survival", "was", "94.5", "%", ".", "Long", "-", "term", "results", "were", "promising", "and", "more", "than", "satisfactory", ",", "leading", "to", "a", "large", "indication", "for", "these", "endosteal", "implants", "." ]	[ "umlsterm" ]
tumor, surgery, face, defects, retrospective study, patients, implants, mastoid, implants, dental implants, survival	MundKieferGesichtschirurgie.9003s130.eng.abstr_task2	Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .	[ "Endosteal", "implants", "after", "tumor", "surgery", "of", "the", "face", "are", "helpful", "in", "reconstructing", "facial", "defects", ".", "A", "retrospective", "study", "of", "our", "patients", "treated", "using", "craniofacial", "implants", "was", "conducted", "to", "evaluate", "long", "-", "term", "results", ".", "A", "total", "of", "128", "implants", "were", "inserted", ",", "110", "implants", "in", "the", "periorbital", ",", "12", "implants", "in", "the", "mastoid", ",", "and", "six", "implants", "in", "the", "paranasal", "region", ";", "113", "implants", "were", "short", "craniofacial", "Brånemark", "implants", ",", "and", "15", "implants", "were", "dental", "implants", ".", "The", "success", "rate", "for", "implant", "survival", "was", "94.5", "%", ".", "Long", "-", "term", "results", "were", "promising", "and", "more", "than", "satisfactory", ",", "leading", "to", "a", "large", "indication", "for", "these", "endosteal", "implants", "." ]	[ "umlsterm" ]
Krankengut is an umlsterm, Therapieziel is an umlsterm, Frakturtypen is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Trauma is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Osteoporose is an umlsterm, AO - Klassifikation is an umlsterm, Frakturen is an umlsterm, Operationszeit is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, Standardverfahren is an umlsterm, Frakturen is an umlsterm	DerUnfallchirurg.01030741.ger.abstr_task0	Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .	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Krankengut is an umlsterm, Therapieziel is an umlsterm, Frakturtypen is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Trauma is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Osteoporose is an umlsterm, AO - Klassifikation is an umlsterm, Frakturen is an umlsterm, Operationszeit is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, Standardverfahren is an umlsterm, Frakturen is an umlsterm	DerUnfallchirurg.01030741.ger.abstr_task1	Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please typing these entity words according to sentence: Krankengut, Therapieziel, Frakturtypen, Frakturen, Patienten, Trauma, radiologisch, Patienten, Morbiditaet, Osteoporose, AO - Klassifikation, Frakturen, Operationszeit, Frakturen, Komplikationen, Frakturen, Komplikationen, Patienten, Frakturen, Standardverfahren, Frakturen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .	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Krankengut, Therapieziel, Frakturtypen, Frakturen, Patienten, Trauma, radiologisch, Patienten, Morbiditaet, Osteoporose, AO - Klassifikation, Frakturen, Operationszeit, Frakturen, Komplikationen, Frakturen, Komplikationen, Patienten, Frakturen, Standardverfahren, Frakturen	DerUnfallchirurg.01030741.ger.abstr_task2	Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .	[ "Bei", "der", "operativen", "Versorgung", "petrochantaerer", "Femurfrakturen", "im", "geriatrischen", "Krankengut", "stellt", "eine", "sofort", "uebungs-", "und", "belastungsstabile", "Osteosynthese", "das", "Therapieziel", "dar", ".", "In", "einer", "klinischen", "Studie", "wurde", "vergleichend", "untersucht", ",", "ob", "dieses", "Ziel", "mit", "der", "DHS", "(", "dynamische", "Hueftschraube", ")", "bei", "allen", "pertrochantaeren", "Frakturtypen", "erreicht", "werden", "kann", ".", "Von", "1994", "-", "1996", "wurden", "122", "pertrochantaere", "Frakturen", "mit", "der", "DHS", "behandelt", ".", "Neben", "der", "Auswertung", "durch", "standardisierte", "Datenerhebungsprotokolle", "wurden", "die", "Patienten", "durchschnittlich", "1,9", "Jahre", "nach", "Trauma", "radiologisch", "und", "klinisch", "nach", "dem", "\"", "Traumatic", "hip", "rating", "score", "\"", "nachuntersucht", "22", "%", ";", "waren", "verstorben", ",", "von", "den", "verbliebenen", "95", "Patienten", "konnten", "51,6", "%", "nachkontrolliert", "werden", ".", "Bei", "einem", "Altersdurchschnitt", "von", "75,5", "Jahren", "lag", "mit", "dem", "ASA", "-", "Score", "von", "durchschnittlich", "2,5", "Punkten", "eine", "hohe", "praeoperative", "Morbiditaet", "vor", ";", "81", "%", "der", "Faelle", "wiesen", "eine", "fortgeschrittene", "Osteoporose", "auf", ".", "Nach", "der", "AO", "-", "Klassifikation", "handelte", "es", "sich", "um", "47", "%", "stabile", "(", "Typ", "A1", ")", "und", "53", "%", "instabile", "(", "Typ", "A2", "und", "A3", ")", "Frakturen", ".", "Die", "mittlere", "Operationszeit", "war", "bei", "den", "instabilen", "im", "Vergleich", "zu", "den", "stabilen", "pertrochantaeren", "Frakturen", "mit", "108", "gegenueber", "77", "min", "signifikant", "hoeher", ",", "der", "Blutverlust", "um", "43", "%", "groesser", ".", "Direkt", "mit", "der", "Osteosynthese", "assoziierte", "Komplikationen", "betrafen", "ausschliesslich", "instabile", "Frakturen", "(", "7", "%", ")", ".", "Allgemeine", "Komplikationen", "(", "24,6", "%", ")", "ueberwogen", "ebenfalls", "mit", "15,6", "%", "in", "der", "Gruppe", "der", "Typ", "A2", "und", "A3", "gegenueber", "der", "Typ", "-", "A1-Frakturen", ",", "was", "sich", "auch", "in", "einer", "entsprechend", "hoeheren", "Klinikletalitaet", "mit", "5,7", "%", "gegenueber", "1,6", "%", "ausdrueckt", ".", "Bei", "der", "Bewertung", "des", "funktionellen", "Nachuntersuchungsergebnisses", "mit", "dem", "THRS", "wiesen", "71", "%", "der", "Patienten", "im", "Vergleich", "zum", "praeoperativen", "Ausgangswert", "eine", "deutliche", "Verschlechterung", "um", "durchschnittlich", "20", "Punkte", "auf", ".", "Die", "Osteosynthese", "instabiler", "pertrochantaerer", "Femurfrakturen", "durch", "die", "DHS", "ist", "mit", "einer", "hoeheren", "Komplikationsrate", "belastet", ".", "Waehrend", "die", "DHS", "fuer", "die", "stabilen", "Frakturen", "das", "Standardverfahren", "darstellt", "muss", "die", "Osteosynthese", "instabiler", "Frakturen", "vor", "dem", "Hintergrund", "neuerer", "operationstechnisch", "und", "biomechanisch", "verbesserter", "intramedullaerer", "Implantate", ",", "kritisch", "betrachtet", "werden", "." ]	[ "umlsterm" ]
IFNα is a GENE-N, IL-22 is a GENE-Y, cytokine is a GENE-N, STAT1 is a GENE-Y	23153456_task0	Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N	[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.	[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
IFNα is a GENE-N, IL-22 is a GENE-Y, cytokine is a GENE-N, STAT1 is a GENE-Y	23153456_task1	Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please typing these entity words according to sentence: IFNα, IL-22, cytokine, STAT1 Options: GENE-Y, GENE-N	[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.	[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
IFNα, IL-22, cytokine, STAT1	23153456_task2	Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.	[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
correlation is a Relation_Trigger, miRNAs is a Non-Specific_miRNAs, APP is a Genes/Proteins	8396_task0	Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes/Proteins, Relation_Trigger, Non-Specific_miRNAs	[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.	[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]
correlation is a Relation_Trigger, miRNAs is a Non-Specific_miRNAs, APP is a Genes/Proteins	8396_task1	Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please typing these entity words according to sentence: correlation, miRNAs, APP Options: Genes/Proteins, Relation_Trigger, Non-Specific_miRNAs	[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.	[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]
correlation, miRNAs, APP	8396_task2	Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.	[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]	[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]
Sir2 is a protein, Sir3 is a protein, telomeric C1 - 3A repeats is a DNA, Sir complex is a protein-complex	1.0alpha7.train.915_task0	Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein, protein-complex	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]	Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.	[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]	[ "DNA", "protein-complex", "protein" ]
Sir2 is a protein, Sir3 is a protein, telomeric C1 - 3A repeats is a DNA, Sir complex is a protein-complex	1.0alpha7.train.915_task1	Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please typing these entity words according to sentence: Sir2, Sir3, telomeric C1 - 3A repeats, Sir complex Options: DNA, protein, protein-complex	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]	Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.	[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]	[ "DNA", "protein-complex", "protein" ]
Sir2, Sir3, telomeric C1 - 3A repeats, Sir complex	1.0alpha7.train.915_task2	Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]	Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.	[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]	[ "DNA", "protein-complex", "protein" ]
T - cell - mediated recognition is an other_name, pml / RAR - alpha hybrid protein is a protein_molecule, lymphocytes is a cell_type, promyelocytic leukemia patients is an other_name	17210_task0	Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_molecule, other_name	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.	[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]	[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]
T - cell - mediated recognition is an other_name, pml / RAR - alpha hybrid protein is a protein_molecule, lymphocytes is a cell_type, promyelocytic leukemia patients is an other_name	17210_task1	Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please typing these entity words according to sentence: T - cell - mediated recognition, pml / RAR - alpha hybrid protein, lymphocytes, promyelocytic leukemia patients Options: cell_type, protein_molecule, other_name	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.	[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]	[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]
T - cell - mediated recognition, pml / RAR - alpha hybrid protein, lymphocytes, promyelocytic leukemia patients	17210_task2	Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.	[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]	[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]
Fra-1 is a Protein, cJun is a Protein, JunD is a Protein, JunB is a Protein, JunB is a Protein	8428966_task0	Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.	[ "Characterization", "of", "the", "nuclear", "and", "cytoplasmic", "components", "of", "the", "lymphoid", "-", "specific", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF", "-", "AT", ")", "complex", ".", "\n", "The", "lymphoid", "-", "specific", "transcription", "complex", ",", "NF", "-", "AT", ",", "is", "involved", "in", "early", "gene", "activation", "in", "T", "cells", "and", "is", "assembled", "from", "a", "pre", "-", "existing", ",", "T", "cell", "restricted", "cytoplasmic", "factor", "and", "an", "inducible", "ubiquitous", "nuclear", "component", "within", "30", "min", "after", "activation", "through", "the", "antigen", "receptor", ".", "Recent", "studies", "have", "implicated", "the", "family", "of", "AP1", "factors", "as", "components", "of", "the", "murine", "NF", "-", "AT", "complex", ".", "Evidence", "is", "provided", "here", "that", "the", "nuclear", "component", "of", "human", "NF", "-", "AT", "contains", "the", "phorbol", "ester", "-", "inducible", "transcription", "factor", "AP1", "(", "Jun", "/", "Fos", ")", ".", "We", "further", "characterize", "which", "AP1", "family", "members", "can", "assume", "this", "role", ".", "Antisera", "to", "Fos", "inhibits", "NF", "-", "AT", "DNA", "binding", "as", "does", "an", "oligonucleotide", "containing", "a", "binding", "site", "for", "AP1", ".", "Constitutive", "expression", "in", "vivo", "of", "Fos", ",", "and", "to", "a", "lesser", "extent", "Fra-1", ",", "eliminates", "the", "requirement", "for", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "stimulation", ",", "leaving", "NF", "-", "AT", "-", "directed", "transcription", "responsive", "to", "calcium", "ionophore", "alone", ".", "Overexpression", "of", "cJun", "or", "JunD", ",", "but", "not", "JunB", ",", "also", "eliminates", "the", "requirement", "for", "PMA", ",", "indicating", "that", "many", "but", "not", "all", "Jun-", "and", "Fos", "-", "related", "proteins", "functionally", "activate", "NF", "-", "AT", "-", "dependent", "transcription", "in", "the", "presence", "of", "the", "cytoplasmic", "component", ".", "NF", "-", "AT", "DNA", "binding", "can", "be", "reconstituted", "in", "vitro", "using", "semi", "-", "purified", "AP1", "proteins", "mixed", "with", "cytosol", "from", "T", "lymphocytes", ".", "Fos", "proteins", "are", "not", "needed", "for", "this", "reconstitution", ",", "and", "although", "JunB", "is", "not", "functional", ",", "it", "can", "participate", "in", "the", "NF", "-", "AT", "DNA", "binding", "complex", ".", "Finally", ",", "we", "have", "partially", "purified", "the", "cytoplasmic", "component", "of", "NF", "-", "AT", "and", "show", "by", "elution", "and", "renaturation", "from", "SDS", "-", "polyacrylamide", "gel", "electrophoresis", "gels", "that", "it", "has", "a", "molecular", "mass", "between", "94", "and", "116", "kDa", "and", "may", "have", "multiple", "differentially", "modified", "forms", "." ]	[ "Protein" ]
Fra-1 is a Protein, cJun is a Protein, JunD is a Protein, JunB is a Protein, JunB is a Protein	8428966_task1	Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please typing these entity words according to sentence: Fra-1, cJun, JunD, JunB, JunB Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.	[ "Characterization", "of", "the", "nuclear", "and", "cytoplasmic", "components", "of", "the", "lymphoid", "-", "specific", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF", "-", "AT", ")", "complex", ".", "\n", "The", "lymphoid", "-", "specific", "transcription", "complex", ",", "NF", "-", "AT", ",", "is", "involved", "in", "early", "gene", "activation", "in", "T", "cells", "and", "is", "assembled", "from", "a", "pre", "-", "existing", ",", "T", "cell", "restricted", "cytoplasmic", "factor", "and", "an", "inducible", "ubiquitous", "nuclear", "component", "within", "30", "min", "after", "activation", "through", "the", "antigen", "receptor", ".", "Recent", "studies", "have", "implicated", "the", "family", "of", "AP1", "factors", "as", "components", "of", "the", "murine", "NF", "-", "AT", "complex", ".", "Evidence", "is", "provided", "here", "that", "the", "nuclear", "component", "of", "human", "NF", "-", "AT", "contains", "the", "phorbol", "ester", "-", "inducible", "transcription", "factor", "AP1", "(", "Jun", "/", "Fos", ")", ".", "We", "further", "characterize", "which", "AP1", "family", "members", "can", "assume", "this", "role", ".", "Antisera", "to", "Fos", "inhibits", "NF", "-", "AT", "DNA", "binding", "as", "does", "an", "oligonucleotide", "containing", "a", "binding", "site", "for", "AP1", ".", "Constitutive", "expression", "in", "vivo", "of", "Fos", ",", "and", "to", "a", "lesser", "extent", "Fra-1", ",", "eliminates", "the", "requirement", "for", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "stimulation", ",", "leaving", "NF", "-", "AT", "-", "directed", "transcription", "responsive", "to", "calcium", "ionophore", "alone", ".", "Overexpression", "of", "cJun", "or", "JunD", ",", "but", "not", "JunB", ",", "also", "eliminates", "the", "requirement", "for", "PMA", ",", "indicating", "that", "many", "but", "not", "all", "Jun-", "and", "Fos", "-", "related", "proteins", "functionally", "activate", "NF", "-", "AT", "-", "dependent", "transcription", "in", "the", "presence", "of", "the", "cytoplasmic", "component", ".", "NF", "-", "AT", "DNA", "binding", "can", "be", "reconstituted", "in", "vitro", "using", "semi", "-", "purified", "AP1", "proteins", "mixed", "with", "cytosol", "from", "T", "lymphocytes", ".", "Fos", "proteins", "are", "not", "needed", "for", "this", "reconstitution", ",", "and", "although", "JunB", "is", "not", "functional", ",", "it", "can", "participate", "in", "the", "NF", "-", "AT", "DNA", "binding", "complex", ".", "Finally", ",", "we", "have", "partially", "purified", "the", "cytoplasmic", "component", "of", "NF", "-", "AT", "and", "show", "by", "elution", "and", "renaturation", "from", "SDS", "-", "polyacrylamide", "gel", "electrophoresis", "gels", "that", "it", "has", "a", "molecular", "mass", "between", "94", "and", "116", "kDa", "and", "may", "have", "multiple", "differentially", "modified", "forms", "." ]	[ "Protein" ]
Fra-1, cJun, JunD, JunB, JunB	8428966_task2	Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.	[ "Characterization", "of", "the", "nuclear", "and", "cytoplasmic", "components", "of", "the", "lymphoid", "-", "specific", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF", "-", "AT", ")", "complex", ".", "\n", "The", "lymphoid", "-", "specific", "transcription", "complex", ",", "NF", "-", "AT", ",", "is", "involved", "in", "early", "gene", "activation", "in", "T", "cells", "and", "is", "assembled", "from", "a", "pre", "-", "existing", ",", "T", "cell", "restricted", "cytoplasmic", "factor", "and", "an", "inducible", "ubiquitous", "nuclear", "component", "within", "30", "min", "after", "activation", "through", "the", "antigen", "receptor", ".", "Recent", "studies", "have", "implicated", "the", "family", "of", "AP1", "factors", "as", "components", "of", "the", "murine", "NF", "-", "AT", "complex", ".", "Evidence", "is", "provided", "here", "that", "the", "nuclear", "component", "of", "human", "NF", "-", "AT", "contains", "the", "phorbol", "ester", "-", "inducible", "transcription", "factor", "AP1", "(", "Jun", "/", "Fos", ")", ".", "We", "further", "characterize", "which", "AP1", "family", "members", "can", "assume", "this", "role", ".", "Antisera", "to", "Fos", "inhibits", "NF", "-", "AT", "DNA", "binding", "as", "does", "an", "oligonucleotide", "containing", "a", "binding", "site", "for", "AP1", ".", "Constitutive", "expression", "in", "vivo", "of", "Fos", ",", "and", "to", "a", "lesser", "extent", "Fra-1", ",", "eliminates", "the", "requirement", "for", "phorbol", "12-myristate", "13-acetate", "(", "PMA", ")", "stimulation", ",", "leaving", "NF", "-", "AT", "-", "directed", "transcription", "responsive", "to", "calcium", "ionophore", "alone", ".", "Overexpression", "of", "cJun", "or", "JunD", ",", "but", "not", "JunB", ",", "also", "eliminates", "the", "requirement", "for", "PMA", ",", "indicating", "that", "many", "but", "not", "all", "Jun-", "and", "Fos", "-", "related", "proteins", "functionally", "activate", "NF", "-", "AT", "-", "dependent", "transcription", "in", "the", "presence", "of", "the", "cytoplasmic", "component", ".", "NF", "-", "AT", "DNA", "binding", "can", "be", "reconstituted", "in", "vitro", "using", "semi", "-", "purified", "AP1", "proteins", "mixed", "with", "cytosol", "from", "T", "lymphocytes", ".", "Fos", "proteins", "are", "not", "needed", "for", "this", "reconstitution", ",", "and", "although", "JunB", "is", "not", "functional", ",", "it", "can", "participate", "in", "the", "NF", "-", "AT", "DNA", "binding", "complex", ".", "Finally", ",", "we", "have", "partially", "purified", "the", "cytoplasmic", "component", "of", "NF", "-", "AT", "and", "show", "by", "elution", "and", "renaturation", "from", "SDS", "-", "polyacrylamide", "gel", "electrophoresis", "gels", "that", "it", "has", "a", "molecular", "mass", "between", "94", "and", "116", "kDa", "and", "may", "have", "multiple", "differentially", "modified", "forms", "." ]	[ "Protein" ]
Pasireotide is a CHEMICAL	23605695_task0	Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pasireotide: A Review of Its Use in Cushing's Disease.	[ "Pasireotide", ":", "A", "Review", "of", "Its", "Use", "in", "Cushing", "'s", "Disease", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Pasireotide is a CHEMICAL	23605695_task1	Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please typing these entity words according to sentence: Pasireotide Options: CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pasireotide: A Review of Its Use in Cushing's Disease.	[ "Pasireotide", ":", "A", "Review", "of", "Its", "Use", "in", "Cushing", "'s", "Disease", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Pasireotide	23605695_task2	Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pasireotide: A Review of Its Use in Cushing's Disease.	[ "Pasireotide", ":", "A", "Review", "of", "Its", "Use", "in", "Cushing", "'s", "Disease", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Acanthosis nigricans is an umlsterm, etiology is an umlsterm, hyperpigmentation is an umlsterm, skin is an umlsterm, development is an umlsterm, Malignant is an umlsterm, acanthosis nigricans is an umlsterm, adenocarcinoma is an umlsterm, time is an umlsterm, diagnosis is an umlsterm, association is an umlsterm, acanthosis nigricans is an umlsterm, transitional cell carcinoma is an umlsterm, urinary bladder is an umlsterm, treatment is an umlsterm, calcipotriol is an umlsterm, skin is an umlsterm	DerHautarzt.90500593.eng.abstr_task0	Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .	[ "Acanthosis", "nigricans", "is", "a", "hyperkeratotic", "mucocutaneous", "eruption", "of", "heterogenous", "etiology", "which", "is", "characterized", "by", "hyperpigmentation", ",", "velvety", "cutaneous", "thickening", ",", "intensified", "skin", "markings", "and", "development", "of", "verrucous", "excrescences", "typically", "involving", "the", "intertriginous", "areas", ".", "Malignant", "acanthosis", "nigricans", "is", "most", "often", "associated", "with", "an", "abdominal", "adenocarcinoma", "frequently", "unresectable", "at", "the", "time", "of", "diagnosis", ".", "We", "report", "on", "the", "rare", "association", "of", "acanthosis", "nigricans", "with", "a", "transitional", "cell", "carcinoma", "of", "the", "urinary", "bladder", ".", "Symptomatic", "treatment", "with", "topical", "calcipotriol", "significantly", "reduced", "the", "hyperkeratotic", "and", "papillomatous", "skin", "changes", "." ]	[ "umlsterm" ]
Acanthosis nigricans is an umlsterm, etiology is an umlsterm, hyperpigmentation is an umlsterm, skin is an umlsterm, development is an umlsterm, Malignant is an umlsterm, acanthosis nigricans is an umlsterm, adenocarcinoma is an umlsterm, time is an umlsterm, diagnosis is an umlsterm, association is an umlsterm, acanthosis nigricans is an umlsterm, transitional cell carcinoma is an umlsterm, urinary bladder is an umlsterm, treatment is an umlsterm, calcipotriol is an umlsterm, skin is an umlsterm	DerHautarzt.90500593.eng.abstr_task1	Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please typing these entity words according to sentence: Acanthosis nigricans, etiology, hyperpigmentation, skin, development, Malignant, acanthosis nigricans, adenocarcinoma, time, diagnosis, association, acanthosis nigricans, transitional cell carcinoma, urinary bladder, treatment, calcipotriol, skin Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .	[ "Acanthosis", "nigricans", "is", "a", "hyperkeratotic", "mucocutaneous", "eruption", "of", "heterogenous", "etiology", "which", "is", "characterized", "by", "hyperpigmentation", ",", "velvety", "cutaneous", "thickening", ",", "intensified", "skin", "markings", "and", "development", "of", "verrucous", "excrescences", "typically", "involving", "the", "intertriginous", "areas", ".", "Malignant", "acanthosis", "nigricans", "is", "most", "often", "associated", "with", "an", "abdominal", "adenocarcinoma", "frequently", "unresectable", "at", "the", "time", "of", "diagnosis", ".", "We", "report", "on", "the", "rare", "association", "of", "acanthosis", "nigricans", "with", "a", "transitional", "cell", "carcinoma", "of", "the", "urinary", "bladder", ".", "Symptomatic", "treatment", "with", "topical", "calcipotriol", "significantly", "reduced", "the", "hyperkeratotic", "and", "papillomatous", "skin", "changes", "." ]	[ "umlsterm" ]
Acanthosis nigricans, etiology, hyperpigmentation, skin, development, Malignant, acanthosis nigricans, adenocarcinoma, time, diagnosis, association, acanthosis nigricans, transitional cell carcinoma, urinary bladder, treatment, calcipotriol, skin	DerHautarzt.90500593.eng.abstr_task2	Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .	[ "Acanthosis", "nigricans", "is", "a", "hyperkeratotic", "mucocutaneous", "eruption", "of", "heterogenous", "etiology", "which", "is", "characterized", "by", "hyperpigmentation", ",", "velvety", "cutaneous", "thickening", ",", "intensified", "skin", "markings", "and", "development", "of", "verrucous", "excrescences", "typically", "involving", "the", "intertriginous", "areas", ".", "Malignant", "acanthosis", "nigricans", "is", "most", "often", "associated", "with", "an", "abdominal", "adenocarcinoma", "frequently", "unresectable", "at", "the", "time", "of", "diagnosis", ".", "We", "report", "on", "the", "rare", "association", "of", "acanthosis", "nigricans", "with", "a", "transitional", "cell", "carcinoma", "of", "the", "urinary", "bladder", ".", "Symptomatic", "treatment", "with", "topical", "calcipotriol", "significantly", "reduced", "the", "hyperkeratotic", "and", "papillomatous", "skin", "changes", "." ]	[ "umlsterm" ]
ecstasy is a Chemicals & Drugs	7512_task0	Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Chemicals & Drugs	[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.	[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]	[ "Diseases & Disorders", "", "Chemicals & Drugs" ]
ecstasy is a Chemicals & Drugs	7512_task1	Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please typing these entity words according to sentence: ecstasy Options: Chemicals & Drugs	[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.	[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]	[ "Diseases & Disorders", "", "Chemicals & Drugs" ]
ecstasy	7512_task2	Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.	[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]	[ "Diseases & Disorders", "", "Chemicals & Drugs" ]
tyrosine phosphorylation is an other_name, endothelial adhesion molecule induction is an other_name	33339_task0	Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name	[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.	[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]	[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]
tyrosine phosphorylation is an other_name, endothelial adhesion molecule induction is an other_name	33339_task1	Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please typing these entity words according to sentence: tyrosine phosphorylation, endothelial adhesion molecule induction Options: other_name	[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.	[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]	[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]
tyrosine phosphorylation, endothelial adhesion molecule induction	33339_task2	Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.	[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]	[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]
symptoms is an umlsterm, disorder is an umlsterm, attention is an umlsterm, spatial perception is an umlsterm, optic is an umlsterm, ataxia is an umlsterm, reading is an umlsterm, orientation is an umlsterm, movement is an umlsterm, element is an umlsterm, review is an umlsterm, etiology is an umlsterm, disorders is an umlsterm, Instructions is an umlsterm, patients is an umlsterm, treatment is an umlsterm, attention is an umlsterm, syndrome is an umlsterm, paper is an umlsterm	DerNervenarzt.90700859.eng.abstr_task0	Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .	[ "Balint", "syndrom", "is", "a", "combination", "of", "symptoms", "including", "simultanagnosia", ",", "a", "disorder", "of", "spatial", "and", "object", "-", "based", "attention", ",", "disturbed", "spatial", "perception", "and", "representation", ",", "and", "optic", "ataxia", "resulting", "from", "bilateral", "parieto", "-", "occipital", "lesions", ".", "Fixation", "and", "ocular", "exploration", "of", "space", "are", "severely", "impaired", ",", "as", "are", "reading", ",", "writing", ",", "drawing", "and", "orientation", "as", "well", "as", "movement", "in", "space", ".", "Low", "-", "level", "visual", "impairments", "may", "be", "associated", "and", "difficult", "to", "evaluate", "but", "are", "not", "a", "necessary", "element", "of", "Balint", "syndrom", ".", "This", "review", "summarizes", "the", "relevant", "facts", "of", "the", "etiology", ",", "localization", "of", "lesions", ",", "and", "the", "core", "features", "as", "well", "as", "frequently", "associated", "disorders", "of", "the", "syndrom", ".", "Instructions", "for", "the", "examination", "of", "patients", "are", "given", "and", "approaches", "for", "the", "management", "and", "treatment", "outlined", ".", "Models", "of", "attention", "and", "space", "representation", "are", "described", "for", "the", "explanation", "of", "this", "multifaceted", "and", "exciting", "syndrome", ".", "Finally", "the", "key", "features", "of", "the", "syndrom", "are", "summarized", "in", "a", "table", "at", "the", "end", "of", "the", "paper", "." ]	[ "umlsterm" ]
symptoms is an umlsterm, disorder is an umlsterm, attention is an umlsterm, spatial perception is an umlsterm, optic is an umlsterm, ataxia is an umlsterm, reading is an umlsterm, orientation is an umlsterm, movement is an umlsterm, element is an umlsterm, review is an umlsterm, etiology is an umlsterm, disorders is an umlsterm, Instructions is an umlsterm, patients is an umlsterm, treatment is an umlsterm, attention is an umlsterm, syndrome is an umlsterm, paper is an umlsterm	DerNervenarzt.90700859.eng.abstr_task1	Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please typing these entity words according to sentence: symptoms, disorder, attention, spatial perception, optic, ataxia, reading, orientation, movement, element, review, etiology, disorders, Instructions, patients, treatment, attention, syndrome, paper Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .	[ "Balint", "syndrom", "is", "a", "combination", "of", "symptoms", "including", "simultanagnosia", ",", "a", "disorder", "of", "spatial", "and", "object", "-", "based", "attention", ",", "disturbed", "spatial", "perception", "and", "representation", ",", "and", "optic", "ataxia", "resulting", "from", "bilateral", "parieto", "-", "occipital", "lesions", ".", "Fixation", "and", "ocular", "exploration", "of", "space", "are", "severely", "impaired", ",", "as", "are", "reading", ",", "writing", ",", "drawing", "and", "orientation", "as", "well", "as", "movement", "in", "space", ".", "Low", "-", "level", "visual", "impairments", "may", "be", "associated", "and", "difficult", "to", "evaluate", "but", "are", "not", "a", "necessary", "element", "of", "Balint", "syndrom", ".", "This", "review", "summarizes", "the", "relevant", "facts", "of", "the", "etiology", ",", "localization", "of", "lesions", ",", "and", "the", "core", "features", "as", "well", "as", "frequently", "associated", "disorders", "of", "the", "syndrom", ".", "Instructions", "for", "the", "examination", "of", "patients", "are", "given", "and", "approaches", "for", "the", "management", "and", "treatment", "outlined", ".", "Models", "of", "attention", "and", "space", "representation", "are", "described", "for", "the", "explanation", "of", "this", "multifaceted", "and", "exciting", "syndrome", ".", "Finally", "the", "key", "features", "of", "the", "syndrom", "are", "summarized", "in", "a", "table", "at", "the", "end", "of", "the", "paper", "." ]	[ "umlsterm" ]
symptoms, disorder, attention, spatial perception, optic, ataxia, reading, orientation, movement, element, review, etiology, disorders, Instructions, patients, treatment, attention, syndrome, paper	DerNervenarzt.90700859.eng.abstr_task2	Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .	[ "Balint", "syndrom", "is", "a", "combination", "of", "symptoms", "including", "simultanagnosia", ",", "a", "disorder", "of", "spatial", "and", "object", "-", "based", "attention", ",", "disturbed", "spatial", "perception", "and", "representation", ",", "and", "optic", "ataxia", "resulting", "from", "bilateral", "parieto", "-", "occipital", "lesions", ".", "Fixation", "and", "ocular", "exploration", "of", "space", "are", "severely", "impaired", ",", "as", "are", "reading", ",", "writing", ",", "drawing", "and", "orientation", "as", "well", "as", "movement", "in", "space", ".", "Low", "-", "level", "visual", "impairments", "may", "be", "associated", "and", "difficult", "to", "evaluate", "but", "are", "not", "a", "necessary", "element", "of", "Balint", "syndrom", ".", "This", "review", "summarizes", "the", "relevant", "facts", "of", "the", "etiology", ",", "localization", "of", "lesions", ",", "and", "the", "core", "features", "as", "well", "as", "frequently", "associated", "disorders", "of", "the", "syndrom", ".", "Instructions", "for", "the", "examination", "of", "patients", "are", "given", "and", "approaches", "for", "the", "management", "and", "treatment", "outlined", ".", "Models", "of", "attention", "and", "space", "representation", "are", "described", "for", "the", "explanation", "of", "this", "multifaceted", "and", "exciting", "syndrome", ".", "Finally", "the", "key", "features", "of", "the", "syndrom", "are", "summarized", "in", "a", "table", "at", "the", "end", "of", "the", "paper", "." ]	[ "umlsterm" ]
literature is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, hypersensitivity is an umlsterm, sugar beet is an umlsterm, disease is an umlsterm, man is an umlsterm, history is an umlsterm, atopic dermatitis is an umlsterm, contact dermatitis is an umlsterm, rhinitis is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, job is an umlsterm, seed is an umlsterm, nursery is an umlsterm	DerHautarzt.60470462.eng.abstr_task0	Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .	[ "Although", "there", "are", "a", "few", "isolated", "reports", "in", "the", "literature", "suggesting", "that", "sugar", "beet", "pollen", "is", "highly", "antigenic", ",", "hypersensitivity", "to", "components", "of", "sugar", "beet", "is", "not", "a", "common", "disease", ".", "We", "report", "a", "29-year", "-", "old", "man", "with", "a", "history", "of", "atopic", "dermatitis", "who", "developed", "both", "contact", "dermatitis", "and", "allergic", "rhinitis", "from", "sugar", "beet", "pollen", "through", "his", "job", "in", "a", "seed", "nursery", "." ]	[ "umlsterm" ]
literature is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, hypersensitivity is an umlsterm, sugar beet is an umlsterm, disease is an umlsterm, man is an umlsterm, history is an umlsterm, atopic dermatitis is an umlsterm, contact dermatitis is an umlsterm, rhinitis is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, job is an umlsterm, seed is an umlsterm, nursery is an umlsterm	DerHautarzt.60470462.eng.abstr_task1	Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please typing these entity words according to sentence: literature, sugar beet, pollen, hypersensitivity, sugar beet, disease, man, history, atopic dermatitis, contact dermatitis, rhinitis, sugar beet, pollen, job, seed, nursery Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .	[ "Although", "there", "are", "a", "few", "isolated", "reports", "in", "the", "literature", "suggesting", "that", "sugar", "beet", "pollen", "is", "highly", "antigenic", ",", "hypersensitivity", "to", "components", "of", "sugar", "beet", "is", "not", "a", "common", "disease", ".", "We", "report", "a", "29-year", "-", "old", "man", "with", "a", "history", "of", "atopic", "dermatitis", "who", "developed", "both", "contact", "dermatitis", "and", "allergic", "rhinitis", "from", "sugar", "beet", "pollen", "through", "his", "job", "in", "a", "seed", "nursery", "." ]	[ "umlsterm" ]
literature, sugar beet, pollen, hypersensitivity, sugar beet, disease, man, history, atopic dermatitis, contact dermatitis, rhinitis, sugar beet, pollen, job, seed, nursery	DerHautarzt.60470462.eng.abstr_task2	Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .	[ "Although", "there", "are", "a", "few", "isolated", "reports", "in", "the", "literature", "suggesting", "that", "sugar", "beet", "pollen", "is", "highly", "antigenic", ",", "hypersensitivity", "to", "components", "of", "sugar", "beet", "is", "not", "a", "common", "disease", ".", "We", "report", "a", "29-year", "-", "old", "man", "with", "a", "history", "of", "atopic", "dermatitis", "who", "developed", "both", "contact", "dermatitis", "and", "allergic", "rhinitis", "from", "sugar", "beet", "pollen", "through", "his", "job", "in", "a", "seed", "nursery", "." ]	[ "umlsterm" ]
p.[D448H;H294Q ] is a SNP, D409H is a SNP	584_task0	Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.	[ "Haplotype", "analysis", "suggests", "a", "single", "Balkan", "origin", "for", "the", "Gaucher", "disease", "[", "D409H;H255Q", "]", "double", "mutant", "allele", ".", "Gaucher", "disease", "is", "an", "autosomal", "recessive", "lysosomal", "storage", "disease", "that", "is", "mainly", "due", "to", "mutations", "in", "the", "GBA", "gene", ".", "Most", "of", "the", "mutant", "alleles", "described", "so", "far", "bear", "a", "single", "mutation", ".", "However", ",", "there", "are", "a", "few", "alleles", "bearing", "two", "or", "more", "DNA", "changes", ".", "It", "has", "been", "reported", "that", "patients", "homozygous", "for", "the", "[", "D409H;H255Q", "]", "double", "mutant", "allele", "(", "HGVS", "-", "approved", "nomenclature", ",", "p.[D448H;H294Q", "]", ")", "present", "a", "more", "severe", "phenotype", "than", "patients", "homozygous", "for", "the", "relatively", "common", "D409H", "mutation", ".", "In", "this", "study", ",", "we", "confirmed", "the", "detrimental", "cumulative", "effect", "of", "these", "two", "mutations", "at", "the", "enzymatic", "activity", "level", "by", "the", "heterologous", "expression", "of", "the", "single", "and", "double", "mutant", "alleles", ".", "Additionally", ",", "we", "found", "a", "high", "frequency", "of", "the", "[", "D409H;H255Q", "]", "allele", "in", "patients", "from", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", ".", "This", "prompted", "us", "to", "perform", "a", "haplotype", "analysis", ",", "using", "five", "microsatellite", "polymorphisms", "close", "to", "the", "GBA", "gene", ",", "to", "determine", "the", "origin", "of", "this", "allele", ".", "The", "results", "of", "the", "37", "chromosomes", "analysed", "showed", "that", "most", "of", "them", "share", "a", "common", "haplotype", "and", "are", "consistent", "with", "a", "single", "origin", "in", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", "for", "the", "[", "D409H;H255Q", "]", "allele", ".", "\n" ]	[ "SNP" ]
p.[D448H;H294Q ] is a SNP, D409H is a SNP	584_task1	Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please typing these entity words according to sentence: p.[D448H;H294Q ], D409H Options: SNP	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.	[ "Haplotype", "analysis", "suggests", "a", "single", "Balkan", "origin", "for", "the", "Gaucher", "disease", "[", "D409H;H255Q", "]", "double", "mutant", "allele", ".", "Gaucher", "disease", "is", "an", "autosomal", "recessive", "lysosomal", "storage", "disease", "that", "is", "mainly", "due", "to", "mutations", "in", "the", "GBA", "gene", ".", "Most", "of", "the", "mutant", "alleles", "described", "so", "far", "bear", "a", "single", "mutation", ".", "However", ",", "there", "are", "a", "few", "alleles", "bearing", "two", "or", "more", "DNA", "changes", ".", "It", "has", "been", "reported", "that", "patients", "homozygous", "for", "the", "[", "D409H;H255Q", "]", "double", "mutant", "allele", "(", "HGVS", "-", "approved", "nomenclature", ",", "p.[D448H;H294Q", "]", ")", "present", "a", "more", "severe", "phenotype", "than", "patients", "homozygous", "for", "the", "relatively", "common", "D409H", "mutation", ".", "In", "this", "study", ",", "we", "confirmed", "the", "detrimental", "cumulative", "effect", "of", "these", "two", "mutations", "at", "the", "enzymatic", "activity", "level", "by", "the", "heterologous", "expression", "of", "the", "single", "and", "double", "mutant", "alleles", ".", "Additionally", ",", "we", "found", "a", "high", "frequency", "of", "the", "[", "D409H;H255Q", "]", "allele", "in", "patients", "from", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", ".", "This", "prompted", "us", "to", "perform", "a", "haplotype", "analysis", ",", "using", "five", "microsatellite", "polymorphisms", "close", "to", "the", "GBA", "gene", ",", "to", "determine", "the", "origin", "of", "this", "allele", ".", "The", "results", "of", "the", "37", "chromosomes", "analysed", "showed", "that", "most", "of", "them", "share", "a", "common", "haplotype", "and", "are", "consistent", "with", "a", "single", "origin", "in", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", "for", "the", "[", "D409H;H255Q", "]", "allele", ".", "\n" ]	[ "SNP" ]
p.[D448H;H294Q ], D409H	584_task2	Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.	[ "Haplotype", "analysis", "suggests", "a", "single", "Balkan", "origin", "for", "the", "Gaucher", "disease", "[", "D409H;H255Q", "]", "double", "mutant", "allele", ".", "Gaucher", "disease", "is", "an", "autosomal", "recessive", "lysosomal", "storage", "disease", "that", "is", "mainly", "due", "to", "mutations", "in", "the", "GBA", "gene", ".", "Most", "of", "the", "mutant", "alleles", "described", "so", "far", "bear", "a", "single", "mutation", ".", "However", ",", "there", "are", "a", "few", "alleles", "bearing", "two", "or", "more", "DNA", "changes", ".", "It", "has", "been", "reported", "that", "patients", "homozygous", "for", "the", "[", "D409H;H255Q", "]", "double", "mutant", "allele", "(", "HGVS", "-", "approved", "nomenclature", ",", "p.[D448H;H294Q", "]", ")", "present", "a", "more", "severe", "phenotype", "than", "patients", "homozygous", "for", "the", "relatively", "common", "D409H", "mutation", ".", "In", "this", "study", ",", "we", "confirmed", "the", "detrimental", "cumulative", "effect", "of", "these", "two", "mutations", "at", "the", "enzymatic", "activity", "level", "by", "the", "heterologous", "expression", "of", "the", "single", "and", "double", "mutant", "alleles", ".", "Additionally", ",", "we", "found", "a", "high", "frequency", "of", "the", "[", "D409H;H255Q", "]", "allele", "in", "patients", "from", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", ".", "This", "prompted", "us", "to", "perform", "a", "haplotype", "analysis", ",", "using", "five", "microsatellite", "polymorphisms", "close", "to", "the", "GBA", "gene", ",", "to", "determine", "the", "origin", "of", "this", "allele", ".", "The", "results", "of", "the", "37", "chromosomes", "analysed", "showed", "that", "most", "of", "them", "share", "a", "common", "haplotype", "and", "are", "consistent", "with", "a", "single", "origin", "in", "the", "Balkans", "and", "the", "Adriatic", "area", "of", "Italy", "for", "the", "[", "D409H;H255Q", "]", "allele", ".", "\n" ]	[ "SNP" ]
tumor necrosis factor alpha is a Protein, interleukin-3 is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein	169_task0	Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.	[ "An", "essential", "role", "for", "NF", "-", "kappaB", "in", "human", "CD34(+", ")", "bone", "marrow", "cell", "survival", ".", "\n", "The", "transcription", "factor", ",", "NF", "-", "kappaB", ",", "is", "important", "for", "T", "-", "cell", "activation", ",", "B", "-", "cell", "maturation", ",", "and", "human", "immunodeficiency", "virus", "transcription", "and", "plays", "a", "role", "in", "alternatively", "mediating", "and", "protecting", "against", "apoptosis", "in", "a", "variety", "of", "cell", "types", ".", "However", ",", "a", "role", "for", "NF", "-", "kappaB", "in", "human", "CD34(+", ")", "bone", "marrow", "cells", "has", "not", "been", "described", ".", "We", "provide", "evidence", "here", "that", "virtually", "all", "human", "CD34(+", ")", "bone", "marrow", "cells", "express", "NF", "-", "kappaB", "that", "can", "be", "activated", "by", "exposure", "to", "phorbol", "12-myristate", "13-acetate", "and", "a", "variety", "of", "cytokines", ",", "eg", ",", "tumor", "necrosis", "factor", "alpha", ",", "interleukin-3", ",", "and", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", ".", "In", "addition", ",", "we", "demonstrate", "that", "NF", "-", "kappaB", "may", "be", "required", "for", "human", "CD34(+", ")", "bone", "marrow", "cell", "clonogenic", "function", "and", "survival", ".", "These", "results", "offer", "insight", "into", "a", "new", "role", "for", "NF", "-", "kappaB", "in", "maintaining", "survival", "and", "function", "in", "hematopoietic", "stem", "and", "progenitor", "cells", "and", "suggest", "that", "proposed", "strategies", "involving", "inhibition", "of", "NF", "-", "kappaB", "activation", "as", "an", "adjunct", "to", "cancer", "chemotherapy", "should", "be", "approached", "with", "caution", "." ]	[ "Protein" ]
tumor necrosis factor alpha is a Protein, interleukin-3 is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein	169_task1	Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please typing these entity words according to sentence: tumor necrosis factor alpha, interleukin-3, granulocyte - macrophage colony - stimulating factor Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.	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tumor necrosis factor alpha, interleukin-3, granulocyte - macrophage colony - stimulating factor	169_task2	Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.	[ "An", "essential", "role", "for", "NF", "-", "kappaB", "in", "human", "CD34(+", ")", "bone", "marrow", "cell", "survival", ".", "\n", "The", "transcription", "factor", ",", "NF", "-", "kappaB", ",", "is", "important", "for", "T", "-", "cell", "activation", ",", "B", "-", "cell", "maturation", ",", "and", "human", "immunodeficiency", "virus", "transcription", "and", "plays", "a", "role", "in", "alternatively", "mediating", "and", "protecting", "against", "apoptosis", "in", "a", "variety", "of", "cell", "types", ".", "However", ",", "a", "role", "for", "NF", "-", "kappaB", "in", "human", "CD34(+", ")", "bone", "marrow", "cells", "has", "not", "been", "described", ".", "We", "provide", "evidence", "here", "that", "virtually", "all", "human", "CD34(+", ")", "bone", "marrow", "cells", "express", "NF", "-", "kappaB", "that", "can", "be", "activated", "by", "exposure", "to", "phorbol", "12-myristate", "13-acetate", "and", "a", "variety", "of", "cytokines", ",", "eg", ",", "tumor", "necrosis", "factor", "alpha", ",", "interleukin-3", ",", "and", "granulocyte", "-", "macrophage", "colony", "-", "stimulating", "factor", ".", "In", "addition", ",", "we", "demonstrate", "that", "NF", "-", "kappaB", "may", "be", "required", "for", "human", "CD34(+", ")", "bone", "marrow", "cell", "clonogenic", "function", "and", "survival", ".", "These", "results", "offer", "insight", "into", "a", "new", "role", "for", "NF", "-", "kappaB", "in", "maintaining", "survival", "and", "function", "in", "hematopoietic", "stem", "and", "progenitor", "cells", "and", "suggest", "that", "proposed", "strategies", "involving", "inhibition", "of", "NF", "-", "kappaB", "activation", "as", "an", "adjunct", "to", "cancer", "chemotherapy", "should", "be", "approached", "with", "caution", "." ]	[ "Protein" ]
CD43 is a protein, T cell is a cell, T cell is a cell, APC membrane is an organelle	1.0alpha7.train.1179_task0	Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell, protein, organelle	[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).	[ "Some", "studies", "have", "suggested", "that", "CD43", "acts", "as", "an", "inhibitor", "of", "T", "cell", "activation", ",", "possibly", "because", "its", "large", "size", "and", "high", "negative", "charge", "(", "Cyster", "et", "al", ".", ",", "1991", ")", "might", "interfere", "with", "close", "binding", "of", "the", "T", "cell", "and", "APC", "membrane", "(", "Manjunath", "et", "al", ".", ",", "1995", ")", "." ]	[ "organelle", "cell", "protein" ]
CD43 is a protein, T cell is a cell, T cell is a cell, APC membrane is an organelle	1.0alpha7.train.1179_task1	Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please typing these entity words according to sentence: CD43, T cell, T cell, APC membrane Options: cell, protein, organelle	[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).	[ "Some", "studies", "have", "suggested", "that", "CD43", "acts", "as", "an", "inhibitor", "of", "T", "cell", "activation", ",", "possibly", "because", "its", "large", "size", "and", "high", "negative", "charge", "(", "Cyster", "et", "al", ".", ",", "1991", ")", "might", "interfere", "with", "close", "binding", "of", "the", "T", "cell", "and", "APC", "membrane", "(", "Manjunath", "et", "al", ".", ",", "1995", ")", "." ]	[ "organelle", "cell", "protein" ]
CD43, T cell, T cell, APC membrane	1.0alpha7.train.1179_task2	Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).	[ "Some", "studies", "have", "suggested", "that", "CD43", "acts", "as", "an", "inhibitor", "of", "T", "cell", "activation", ",", "possibly", "because", "its", "large", "size", "and", "high", "negative", "charge", "(", "Cyster", "et", "al", ".", ",", "1991", ")", "might", "interfere", "with", "close", "binding", "of", "the", "T", "cell", "and", "APC", "membrane", "(", "Manjunath", "et", "al", ".", ",", "1995", ")", "." ]	[ "organelle", "cell", "protein" ]
adaptations is an umlsterm, human is an umlsterm, pregnancy is an umlsterm, ovulation is an umlsterm, heart rate is an umlsterm, blood pressure is an umlsterm, stroke volume is an umlsterm, cardiac output is an umlsterm, peripheral resistance is an umlsterm, compliance is an umlsterm, standard is an umlsterm, menstrual cycle is an umlsterm, conception is an umlsterm, conception is an umlsterm, Techniques is an umlsterm, EKG is an umlsterm, blood pressure is an umlsterm, measurement is an umlsterm, plethysmography is an umlsterm, conception is an umlsterm, conception is an umlsterm, time is an umlsterm, human chorionic gonadotropin is an umlsterm, estradiol is an umlsterm, progesterone is an umlsterm	DerGynaekologe.90320360.eng.abstr_task0	Sentence: To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu .	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adaptations is an umlsterm, human is an umlsterm, pregnancy is an umlsterm, ovulation is an umlsterm, heart rate is an umlsterm, blood pressure is an umlsterm, stroke volume is an umlsterm, cardiac output is an umlsterm, peripheral resistance is an umlsterm, compliance is an umlsterm, standard is an umlsterm, menstrual cycle is an umlsterm, conception is an umlsterm, conception is an umlsterm, Techniques is an umlsterm, EKG is an umlsterm, blood pressure is an umlsterm, measurement is an umlsterm, plethysmography is an umlsterm, conception is an umlsterm, conception is an umlsterm, time is an umlsterm, human chorionic gonadotropin is an umlsterm, estradiol is an umlsterm, progesterone is an umlsterm	DerGynaekologe.90320360.eng.abstr_task1	Sentence: To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu . Instructions: please typing these entity words according to sentence: adaptations, human, pregnancy, ovulation, heart rate, blood pressure, stroke volume, cardiac output, peripheral resistance, compliance, standard, menstrual cycle, conception, conception, Techniques, EKG, blood pressure, measurement, plethysmography, conception, conception, time, human chorionic gonadotropin, estradiol, progesterone Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu .	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prophylaxis is an umlsterm, therapy is an umlsterm, ointment is an umlsterm, glass is an umlsterm, glass is an umlsterm, patients is an umlsterm, feeling is an umlsterm, physical handicap is an umlsterm, therapeutic is an umlsterm, gravity is an umlsterm, gold is an umlsterm, implantation is an umlsterm, Methods is an umlsterm, patients is an umlsterm, lead is an umlsterm, weights is an umlsterm, patients is an umlsterm, adhesive is an umlsterm, skin is an umlsterm, method is an umlsterm, persons is an umlsterm, patients is an umlsterm, method is an umlsterm, patients is an umlsterm, procedure is an umlsterm, visual function is an umlsterm, cosmetics is an umlsterm, glass is an umlsterm, lead is an umlsterm, weights is an umlsterm, adhesive is an umlsterm, method is an umlsterm, gold is an umlsterm, implantation is an umlsterm

DerNervenarzt.60670667.eng.abstr_task1

Sentence: Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation . Instructions: please typing these entity words according to sentence: prophylaxis, therapy, ointment, glass, glass, patients, feeling, physical handicap, therapeutic, gravity, gold, implantation, Methods, patients, lead, weights, patients, adhesive, skin, method, persons, patients, method, patients, procedure, visual function, cosmetics, glass, lead, weights, adhesive, method, gold, implantation Options: umlsterm

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Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation .

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[ "umlsterm" ]

prophylaxis, therapy, ointment, glass, glass, patients, feeling, physical handicap, therapeutic, gravity, gold, implantation, Methods, patients, lead, weights, patients, adhesive, skin, method, persons, patients, method, patients, procedure, visual function, cosmetics, glass, lead, weights, adhesive, method, gold, implantation

DerNervenarzt.60670667.eng.abstr_task2

Sentence: Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation . Instructions: please extract entity words from the input sentence

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Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The " liddynamic " procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : " lidloading " with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation .

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[ "umlsterm" ]

symptoms is an umlsterm, odontogenic tumors is an umlsterm, bone is an umlsterm, Root resorptions is an umlsterm, development is an umlsterm, today 's is an umlsterm, classification is an umlsterm, odontogenic tumors is an umlsterm, neoplasm is an umlsterm, therapeutic is an umlsterm, malignant is an umlsterm, tumors is an umlsterm, recurrences is an umlsterm

MundKieferGesichtschirurgie.0004s187.eng.abstr_task0

Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .

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[ "umlsterm" ]

symptoms is an umlsterm, odontogenic tumors is an umlsterm, bone is an umlsterm, Root resorptions is an umlsterm, development is an umlsterm, today 's is an umlsterm, classification is an umlsterm, odontogenic tumors is an umlsterm, neoplasm is an umlsterm, therapeutic is an umlsterm, malignant is an umlsterm, tumors is an umlsterm, recurrences is an umlsterm

MundKieferGesichtschirurgie.0004s187.eng.abstr_task1

Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please typing these entity words according to sentence: symptoms, odontogenic tumors, bone, Root resorptions, development, today 's, classification, odontogenic tumors, neoplasm, therapeutic, malignant, tumors, recurrences Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .

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[ "umlsterm" ]

symptoms, odontogenic tumors, bone, Root resorptions, development, today 's, classification, odontogenic tumors, neoplasm, therapeutic, malignant, tumors, recurrences

MundKieferGesichtschirurgie.0004s187.eng.abstr_task2

Sentence: The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

The clinical symptoms of odontogenic tumors are non-specific . On the roentgenographs one most often sees radiolucencies within the bone , sometimes in combination with scattered or diffuse radioopacities . Root resorptions may be another important feature . After a short historical introduction on the development of today's classification of odontogenic tumors ( WHO ) , each individual type of neoplasm is discussed briefly . Out of this , a therapeutic regime is developed that places each of the 22 entities into one of the following four groups : malignant , locally aggressive , tumors with recurrences , and non-recurrent ones .

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[ "umlsterm" ]

efficacy is a Outcome_Other, gemcitabine to adjuvant therapy is a Intervention_Pharmacological, lymph node - positive breast cancer is a Participant_Condition

63575_task0

Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Participant_Condition

[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]

No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .

[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]

[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]

efficacy is a Outcome_Other, gemcitabine to adjuvant therapy is a Intervention_Pharmacological, lymph node - positive breast cancer is a Participant_Condition

63575_task1

Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please typing these entity words according to sentence: efficacy, gemcitabine to adjuvant therapy, lymph node - positive breast cancer Options: Outcome_Other, Intervention_Pharmacological, Participant_Condition

[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]

No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .

[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]

[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]

efficacy, gemcitabine to adjuvant therapy, lymph node - positive breast cancer

63575_task2

Sentence: No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O" ]

No gains in efficacy observed by adding gemcitabine to adjuvant therapy for lymph node-positive breast cancer .

[ "No", "gains", "in", "efficacy", "observed", "by", "adding", "gemcitabine", "to", "adjuvant", "therapy", "for", "lymph", "node", "-", "positive", "breast", "cancer", "." ]

[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other" ]

Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Schmerzkontrolle is an umlsterm, Hypnose is an umlsterm, Schmerzen is an umlsterm, Schmerzkontrolle is an umlsterm, Techniken is an umlsterm, Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Hypnose is an umlsterm, Techniken is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, Hypnose is an umlsterm

DerSchmerz.80120179.ger.abstr_task0

Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .

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[ "umlsterm" ]

Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Schmerzkontrolle is an umlsterm, Hypnose is an umlsterm, Schmerzen is an umlsterm, Schmerzkontrolle is an umlsterm, Techniken is an umlsterm, Hypnose is an umlsterm, Schmerzbehandlung is an umlsterm, Hypnose is an umlsterm, Techniken is an umlsterm, Schmerz is an umlsterm, Kontraindikationen is an umlsterm, Hypnose is an umlsterm

DerSchmerz.80120179.ger.abstr_task1

Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please typing these entity words according to sentence: Hypnose, Schmerzbehandlung, Schmerzkontrolle, Hypnose, Schmerzen, Schmerzkontrolle, Techniken, Hypnose, Schmerzbehandlung, Hypnose, Techniken, Schmerz, Kontraindikationen, Hypnose Options: umlsterm

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Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .

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[ "umlsterm" ]

Hypnose, Schmerzbehandlung, Schmerzkontrolle, Hypnose, Schmerzen, Schmerzkontrolle, Techniken, Hypnose, Schmerzbehandlung, Hypnose, Techniken, Schmerz, Kontraindikationen, Hypnose

DerSchmerz.80120179.ger.abstr_task2

Sentence: Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Hinsichtlich der Moeglichkeiten der Hypnose in der Schmerzbehandlung werden zunaechst relevante Untersuchungen zur hypnotischen Schmerzkontrolle referiert . Hierbei zeigt sich , dass die Effektivitaet der Hypnose zur Kontrolle von Schmerzen in experimentellen Untersuchungen gut nachgewiesen ist ; wesentlich uneindeutiger ist die Situation allerdings bei den entsprechenden klinischen Studien . Es werden 3 grundlegende Strategien hypnotischer Schmerzkontrolle dargestellt , unter die sich die verschiedenen Techniken subsumieren lassen : dissoziative assoziative und symbolische . , Zu den Grenzen der Hypnose in der Schmerzbehandlung tragen verschiedene Faktoren bei wie z . B. Hypnose als Zustand , Hypnotisierbarkeit , Rapport , hypnotische Techniken und Schmerz als multifaktorieller Prozess . Diese Faktoren werden eroertert und die daraus resultierenden Kontraindikationen aufgezeigt . Insbesondere wird auf die Unterscheidung zwischen symptom- und problemorientierter Hypnose bzw. Hypnotherapie hingewiesen .

[ "Hinsichtlich", "der", "Moeglichkeiten", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "werden", "zunaechst", "relevante", "Untersuchungen", "zur", "hypnotischen", "Schmerzkontrolle", "referiert", ".", "Hierbei", "zeigt", "sich", ",", "dass", "die", "Effektivitaet", "der", "Hypnose", "zur", "Kontrolle", "von", "Schmerzen", "in", "experimentellen", "Untersuchungen", "gut", "nachgewiesen", "ist", ";", "wesentlich", "uneindeutiger", "ist", "die", "Situation", "allerdings", "bei", "den", "entsprechenden", "klinischen", "Studien", ".", "Es", "werden", "3", "grundlegende", "Strategien", "hypnotischer", "Schmerzkontrolle", "dargestellt", ",", "unter", "die", "sich", "die", "verschiedenen", "Techniken", "subsumieren", "lassen", ":", "dissoziative", "assoziative", "und", "symbolische", ".", ",", "Zu", "den", "Grenzen", "der", "Hypnose", "in", "der", "Schmerzbehandlung", "tragen", "verschiedene", "Faktoren", "bei", "wie", "z", ".", "B.", "Hypnose", "als", "Zustand", ",", "Hypnotisierbarkeit", ",", "Rapport", ",", "hypnotische", "Techniken", "und", "Schmerz", "als", "multifaktorieller", "Prozess", ".", "Diese", "Faktoren", "werden", "eroertert", "und", "die", "daraus", "resultierenden", "Kontraindikationen", "aufgezeigt", ".", "Insbesondere", "wird", "auf", "die", "Unterscheidung", "zwischen", "symptom-", "und", "problemorientierter", "Hypnose", "bzw", ".", "Hypnotherapie", "hingewiesen", "." ]

[ "umlsterm" ]

NADPH is a compound, CPR is a protein

DS.d1868_task0

Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.

[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]

[ "compound", "protein" ]

NADPH is a compound, CPR is a protein

DS.d1868_task1

Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please typing these entity words according to sentence: NADPH, CPR Options: compound, protein

[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.

[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]

[ "compound", "protein" ]

NADPH, CPR

DS.d1868_task2

Sentence: The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-compound", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.

[ "The", "electrons", "released", "from", "NADPH", "by", "CPR", "were", "transferred", "to", "CTC", "in", "the", "reaction", "medium", ",", "and", "CTC", "reduction", "activity", "could", "be", "assessed", "spectrophotometrically", "and", "spectrofluorometrically", "." ]

[ "compound", "protein" ]

findings is an umlsterm, retinal is an umlsterm, patients is an umlsterm, procedures is an umlsterm

DerOpthalmologe.00970353.eng.abstr_task0

Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .

[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]

[ "umlsterm" ]

findings is an umlsterm, retinal is an umlsterm, patients is an umlsterm, procedures is an umlsterm

DerOpthalmologe.00970353.eng.abstr_task1

Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please typing these entity words according to sentence: findings, retinal, patients, procedures Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .

[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]

[ "umlsterm" ]

findings, retinal, patients, procedures

DerOpthalmologe.00970353.eng.abstr_task2

Sentence: Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To study early and late findings of macular retinal thickness in patients with hypotony following filtering procedures .

[ "Purpose", ":", "To", "study", "early", "and", "late", "findings", "of", "macular", "retinal", "thickness", "in", "patients", "with", "hypotony", "following", "filtering", "procedures", "." ]

[ "umlsterm" ]

Pelvic floor is an umlsterm, Anatomy is an umlsterm, pelvic floor is an umlsterm, physiology is an umlsterm, fascia is an umlsterm, anatomic is an umlsterm, form is an umlsterm, plate is an umlsterm

DerRadiologe.00400429.eng.abstr_task0

Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .

[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]

[ "umlsterm" ]

Pelvic floor is an umlsterm, Anatomy is an umlsterm, pelvic floor is an umlsterm, physiology is an umlsterm, fascia is an umlsterm, anatomic is an umlsterm, form is an umlsterm, plate is an umlsterm

DerRadiologe.00400429.eng.abstr_task1

Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please typing these entity words according to sentence: Pelvic floor, Anatomy, pelvic floor, physiology, fascia, anatomic, form, plate Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .

[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]

[ "umlsterm" ]

Pelvic floor, Anatomy, pelvic floor, physiology, fascia, anatomic, form, plate

DerRadiologe.00400429.eng.abstr_task2

Sentence: Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

Pelvic floor . Anatomy of the pelvic floor seemed to be clearly . In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood . Especially the anatomic form of the levator plate does not conform with physiologic concepts .

[ "Pelvic", "floor", ".", "Anatomy", "of", "the", "pelvic", "floor", "seemed", "to", "be", "clearly", ".", "In", "opposite", "the", "physiology", "of", "the", "Levator", "ani", "and", "the", "endopelvic", "fascia", "is", "not", "yet", "fully", "understood", ".", "Especially", "the", "anatomic", "form", "of", "the", "levator", "plate", "does", "not", "conform", "with", "physiologic", "concepts", "." ]

[ "umlsterm" ]

Met326Ile is a ProteinMutation

1283_task0

Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation

[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.

[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]

[ "ProteinMutation" ]

Met326Ile is a ProteinMutation

1283_task1

Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please typing these entity words according to sentence: Met326Ile Options: ProteinMutation

[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.

[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]

[ "ProteinMutation" ]

Met326Ile

1283_task2

Sentence: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O" ]

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome.

[ "Phosphatidylinositol", "3-kinase", "p85alpha", "regulatory", "subunit", "gene", "Met326Ile", "polymorphism", "in", "women", "with", "polycystic", "ovary", "syndrome", "." ]

[ "ProteinMutation" ]

Keratoakanthom is an umlsterm, Therapie is an umlsterm, Methotrexat is an umlsterm, Tumorregression is an umlsterm, Therapie is an umlsterm, Tumoren is an umlsterm

DerHautarzt.00510612.ger.abstr_task0

Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .

[ "Eine", "53", "Jahre", "alte", "Patientin", "entwickelte", "ueber", "2", "Monate", "ein", "Keratoakanthom", "am", "linken", "Nasenfluegel", ".", "Nach", "wiederholten", "erfolglosen", "kryotherapeutischen", "Behandlungsversuchen", "erfolgten", "zweimal", "im", "Abstand", "von", "7", "Tagen", "intralaesionale", "Methothrexat", "-", "Injektionen", ",", "wonach", "es", "innerhalb", "von", "5", "Wochen", "zu", "einer", "vollstaendigen", "Abheilung", "kam", ".", "Obwohl", "kontrollierte", "Studien", "ueber", "die", "Therapie", "von", "Keratoakanthomen", "mit", "Methotrexat", "bislang", "fehlen", ",", "legt", "die", "schnelle", "Tumorregression", "und", "das", "gute", "kosmetische", "Ergebnis", "diese", "Art", "der", "Therapie", "bei", "operationstechnisch", "schwierig", "lokalisierten", "Tumoren", "nahe", "." ]

[ "umlsterm" ]

Keratoakanthom is an umlsterm, Therapie is an umlsterm, Methotrexat is an umlsterm, Tumorregression is an umlsterm, Therapie is an umlsterm, Tumoren is an umlsterm

DerHautarzt.00510612.ger.abstr_task1

Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please typing these entity words according to sentence: Keratoakanthom, Therapie, Methotrexat, Tumorregression, Therapie, Tumoren Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .

[ "Eine", "53", "Jahre", "alte", "Patientin", "entwickelte", "ueber", "2", "Monate", "ein", "Keratoakanthom", "am", "linken", "Nasenfluegel", ".", "Nach", "wiederholten", "erfolglosen", "kryotherapeutischen", "Behandlungsversuchen", "erfolgten", "zweimal", "im", "Abstand", "von", "7", "Tagen", "intralaesionale", "Methothrexat", "-", "Injektionen", ",", "wonach", "es", "innerhalb", "von", "5", "Wochen", "zu", "einer", "vollstaendigen", "Abheilung", "kam", ".", "Obwohl", "kontrollierte", "Studien", "ueber", "die", "Therapie", "von", "Keratoakanthomen", "mit", "Methotrexat", "bislang", "fehlen", ",", "legt", "die", "schnelle", "Tumorregression", "und", "das", "gute", "kosmetische", "Ergebnis", "diese", "Art", "der", "Therapie", "bei", "operationstechnisch", "schwierig", "lokalisierten", "Tumoren", "nahe", "." ]

[ "umlsterm" ]

Keratoakanthom, Therapie, Methotrexat, Tumorregression, Therapie, Tumoren

DerHautarzt.00510612.ger.abstr_task2

Sentence: Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Eine 53 Jahre alte Patientin entwickelte ueber 2 Monate ein Keratoakanthom am linken Nasenfluegel . Nach wiederholten erfolglosen kryotherapeutischen Behandlungsversuchen erfolgten zweimal im Abstand von 7 Tagen intralaesionale Methothrexat-Injektionen , wonach es innerhalb von 5 Wochen zu einer vollstaendigen Abheilung kam . Obwohl kontrollierte Studien ueber die Therapie von Keratoakanthomen mit Methotrexat bislang fehlen , legt die schnelle Tumorregression und das gute kosmetische Ergebnis diese Art der Therapie bei operationstechnisch schwierig lokalisierten Tumoren nahe .

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[ "umlsterm" ]

paroxetine is a compound, SERT is a protein

DS.d349_task0

Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]

The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.

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[ "compound", "protein" ]

paroxetine is a compound, SERT is a protein

DS.d349_task1

Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please typing these entity words according to sentence: paroxetine, SERT Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]

The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.

[ "The", "equality", "of", "K", "(", "D", ")", "of", "paroxetine", "binding", "to", "blood", "platelet", "membranes", "and", "to", "membranes", "from", "nerve", "endings", "appears", "to", "encourage", "the", "use", "of", "such", "membranes", "as", "a", "model", "for", "brain", "SERT", "." ]

[ "compound", "protein" ]

paroxetine, SERT

DS.d349_task2

Sentence: The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O" ]

The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.

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[ "compound", "protein" ]

Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, Hirnbiopsie is an umlsterm, Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, Gliomatosis cerebri is an umlsterm, Tumorzellen is an umlsterm, Diagnosefindung is an umlsterm, Kontrastmittelaufnahme is an umlsterm, Drucksteigerung is an umlsterm, Differentialdiagnosen is an umlsterm, Literatur is an umlsterm

DerNervenarzt.00710481.ger.abstr_task0

Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .

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[ "umlsterm" ]

Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, radiologischen is an umlsterm, Patienten is an umlsterm, Hirnbiopsie is an umlsterm, Diagnose is an umlsterm, Gliomatosis cerebri is an umlsterm, Gliomatosis cerebri is an umlsterm, Tumorzellen is an umlsterm, Diagnosefindung is an umlsterm, Kontrastmittelaufnahme is an umlsterm, Drucksteigerung is an umlsterm, Differentialdiagnosen is an umlsterm, Literatur is an umlsterm

DerNervenarzt.00710481.ger.abstr_task1

Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please typing these entity words according to sentence: Diagnose, Gliomatosis cerebri, radiologischen, Patienten, Hirnbiopsie, Diagnose, Gliomatosis cerebri, Gliomatosis cerebri, Tumorzellen, Diagnosefindung, Kontrastmittelaufnahme, Drucksteigerung, Differentialdiagnosen, Literatur Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .

[ "Die", "Diagnose", "der", "seltenen", "Gliomatosis", "cerebri", "kann", "nur", "in", "Zusammenschau", "von", "klinischen", ",", "radiologischen", "und", "histopathologischen", "Befunden", "gestellt", "werden", ".", "Im", "vorliegenden", "Artikel", "berichten", "wir", "ueber", "2", "Patienten", ",", "bei", "denen", "intra", "vitam", "nach", "stereotaktischer", "Hirnbiopsie", "die", "Diagnose", "Gliomatosis", "cerebri", "gesichert", "wurde", ".", "Da", "in", "beiden", "Faellen", "fuer", "Gliomatosis", "cerebri", "ungewoehnlich", "hochgradig", "entdifferenzierte", "Tumorzellen", "vorlagen", ",", "wurde", "die", "Diagnosefindung", "durch", "atypische", "Befunde", "wie", "Kontrastmittelaufnahme", "im", "MRT", "und", "klinische", "Zeichen", "der", "intrakraniellen", "Drucksteigerung", "erschwert", ".", "Klinischer", "Verlauf", ",", "Differentialdiagnosen", "und", "Literatur", "werden", "kurz", "dargestellt", "." ]

[ "umlsterm" ]

Diagnose, Gliomatosis cerebri, radiologischen, Patienten, Hirnbiopsie, Diagnose, Gliomatosis cerebri, Gliomatosis cerebri, Tumorzellen, Diagnosefindung, Kontrastmittelaufnahme, Drucksteigerung, Differentialdiagnosen, Literatur

DerNervenarzt.00710481.ger.abstr_task2

Sentence: Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Die Diagnose der seltenen Gliomatosis cerebri kann nur in Zusammenschau von klinischen , radiologischen und histopathologischen Befunden gestellt werden . Im vorliegenden Artikel berichten wir ueber 2 Patienten , bei denen intra vitam nach stereotaktischer Hirnbiopsie die Diagnose Gliomatosis cerebri gesichert wurde . Da in beiden Faellen fuer Gliomatosis cerebri ungewoehnlich hochgradig entdifferenzierte Tumorzellen vorlagen , wurde die Diagnosefindung durch atypische Befunde wie Kontrastmittelaufnahme im MRT und klinische Zeichen der intrakraniellen Drucksteigerung erschwert . Klinischer Verlauf , Differentialdiagnosen und Literatur werden kurz dargestellt .

[ "Die", "Diagnose", "der", "seltenen", "Gliomatosis", "cerebri", "kann", "nur", "in", "Zusammenschau", "von", "klinischen", ",", "radiologischen", "und", "histopathologischen", "Befunden", "gestellt", "werden", ".", "Im", "vorliegenden", "Artikel", "berichten", "wir", "ueber", "2", "Patienten", ",", "bei", "denen", "intra", "vitam", "nach", "stereotaktischer", "Hirnbiopsie", "die", "Diagnose", "Gliomatosis", "cerebri", "gesichert", "wurde", ".", "Da", "in", "beiden", "Faellen", "fuer", "Gliomatosis", "cerebri", "ungewoehnlich", "hochgradig", "entdifferenzierte", "Tumorzellen", "vorlagen", ",", "wurde", "die", "Diagnosefindung", "durch", "atypische", "Befunde", "wie", "Kontrastmittelaufnahme", "im", "MRT", "und", "klinische", "Zeichen", "der", "intrakraniellen", "Drucksteigerung", "erschwert", ".", "Klinischer", "Verlauf", ",", "Differentialdiagnosen", "und", "Literatur", "werden", "kurz", "dargestellt", "." ]

[ "umlsterm" ]

MAD3 is a Protein, I kappa B alpha is a Protein, MAD3 is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein

378_task0

Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

MAD3 is a Protein, I kappa B alpha is a Protein, MAD3 is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein

378_task1

Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: MAD3, I kappa B alpha, MAD3, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha Options: Protein

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

MAD3, I kappa B alpha, MAD3, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha

378_task2

Sentence: N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide. In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein. By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha. Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation. Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. (ABSTRACT TRUNCATED AT 250 WORDS)

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[ "Protein" ]

Lovenox is a BRAND, anticoagulants is a GROUP, platelet inhibitors is a GROUP, acetylsalicylic acid is a DRUG, NSAIDs is a GROUP, ketorolac tromethamine is a DRUG, dipyridamole is a DRUG, sulfinpyrazone is a DRUG

Enoxaparin_ddi_task0

Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG, BRAND

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .

[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]

[ "DRUG", "GROUP", "BRAND" ]

Lovenox is a BRAND, anticoagulants is a GROUP, platelet inhibitors is a GROUP, acetylsalicylic acid is a DRUG, NSAIDs is a GROUP, ketorolac tromethamine is a DRUG, dipyridamole is a DRUG, sulfinpyrazone is a DRUG

Enoxaparin_ddi_task1

Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please typing these entity words according to sentence: Lovenox, anticoagulants, platelet inhibitors, acetylsalicylic acid, NSAIDs, ketorolac tromethamine, dipyridamole, sulfinpyrazone Options: GROUP, DRUG, BRAND

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .

[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]

[ "DRUG", "GROUP", "BRAND" ]

Lovenox, anticoagulants, platelet inhibitors, acetylsalicylic acid, NSAIDs, ketorolac tromethamine, dipyridamole, sulfinpyrazone

Enoxaparin_ddi_task2

Sentence: Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-GROUP", "I-GROUP", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "B-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring .

[ "Unless", "really", "needed", ",", "agents", "which", "may", "enhance", "the", "risk", "of", "hemorrhage", "should", "be", "discontinued", "prior", "to", "initiation", "of", "Lovenox", "Injection", "therapy", ".", "These", "agents", "include", "medications", "such", "as", ":", "anticoagulants", ",", "platelet", "inhibitors", "including", "acetylsalicylic", "acid", ",", "sali", "-", "cylates", ",", "NSAIDs", "(", "including", "ketorolac", "tromethamine", ")", ",", "dipyridamole", ",", "or", "sulfinpyrazone", ".", "If", "co", "-", "administration", "is", "essential", ",", "conduct", "close", "clinical", "and", "laboratory", "monitoring", "." ]

[ "DRUG", "GROUP", "BRAND" ]

U2 snRNP is a RNA, SF3a is a protein-complex, SF3b is a protein-complex, U2 snRNP is a RNA, pre - mRNAs is a RNA

1.0alpha7.train.862_task0

Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: RNA, protein-complex

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]

Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).

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[ "RNA", "protein-complex" ]

U2 snRNP is a RNA, SF3a is a protein-complex, SF3b is a protein-complex, U2 snRNP is a RNA, pre - mRNAs is a RNA

1.0alpha7.train.862_task1

Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please typing these entity words according to sentence: U2 snRNP, SF3a, SF3b, U2 snRNP, pre - mRNAs Options: RNA, protein-complex

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]

Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).

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[ "RNA", "protein-complex" ]

U2 snRNP, SF3a, SF3b, U2 snRNP, pre - mRNAs

1.0alpha7.train.862_task2

Sentence: Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-protein-complex", "O", "O", "B-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "B-RNA", "I-RNA", "O", "O", "B-RNA", "I-RNA", "I-RNA", "O", "O", "O", "O", "O", "O", "O" ]

Fractionation of splicing extracts showed that two fractions associated with U2 snRNP, SF3a and SF3b, are required for the binding of U2 snRNP to pre-mRNAs ( 10, 31).

[ "Fractionation", "of", "splicing", "extracts", "showed", "that", "two", "fractions", "associated", "with", " ", "U2", "snRNP", ",", " ", "SF3a", "and", " ", "SF3b", ",", "are", "required", "for", "the", "binding", "of", " ", "U2", "snRNP", "to", " ", "pre", "-", "mRNAs", "(", "10", ",", " ", "31", ")", "." ]

[ "RNA", "protein-complex" ]

Runx3 is a Protein, Runx3 is a Protein, Eomes is a Protein, T - bet is a Protein, perforin is a Protein, CD8 is a Protein, beta - Actin is a Protein, Prf1 is a Protein, CD8 is a Protein, beta - Actin is a Protein, granzyme B is a Protein, IFN - gamma is a Protein, TNF is a Protein, IL-2 is a Protein, CD8 is a Protein, granzyme B is a Protein, Runx3 is a Protein, Eomes is a Protein, Prf1 is a Protein, CD8 is a Protein, Prf1 is a Protein, Runx3 is a Protein, Eomes is a Protein

218_task0

Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O" ]

Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.

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[ "Protein" ]

Runx3 is a Protein, Runx3 is a Protein, Eomes is a Protein, T - bet is a Protein, perforin is a Protein, CD8 is a Protein, beta - Actin is a Protein, Prf1 is a Protein, CD8 is a Protein, beta - Actin is a Protein, granzyme B is a Protein, IFN - gamma is a Protein, TNF is a Protein, IL-2 is a Protein, CD8 is a Protein, granzyme B is a Protein, Runx3 is a Protein, Eomes is a Protein, Prf1 is a Protein, CD8 is a Protein, Prf1 is a Protein, Runx3 is a Protein, Eomes is a Protein

218_task1

Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please typing these entity words according to sentence: Runx3, Runx3, Eomes, T - bet, perforin, CD8, beta - Actin, Prf1, CD8, beta - Actin, granzyme B, IFN - gamma, TNF, IL-2, CD8, granzyme B, Runx3, Eomes, Prf1, CD8, Prf1, Runx3, Eomes Options: Protein

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Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.

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[ "Protein" ]

Runx3, Runx3, Eomes, T - bet, perforin, CD8, beta - Actin, Prf1, CD8, beta - Actin, granzyme B, IFN - gamma, TNF, IL-2, CD8, granzyme B, Runx3, Eomes, Prf1, CD8, Prf1, Runx3, Eomes

218_task2

Sentence: Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP. Instructions: please extract entity words from the input sentence

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Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. beta-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3-/- CD8+ T cells differentiated for 6 d. beta-Actin was used as a loading control. (C) Expression of granzyme B, IFN-gamma, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3-/- CD8+ SP T cells differentiated for 6 d. The vertical gray line indicates the granzyme B MFI for WT GFP+ cells. Results in A-C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus. Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin. The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations. The efficiency of recovery of input for the -1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.

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[ "Protein" ]

Death is an umlsterm, taboos is an umlsterm, society is an umlsterm, medicine is an umlsterm, cause is an umlsterm, uncertainty is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, dying patients is an umlsterm, method is an umlsterm, trauma is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, voluntary helpers is an umlsterm, resonance is an umlsterm, elements is an umlsterm, sensitivity is an umlsterm, mood is an umlsterm, fantasy is an umlsterm, method is an umlsterm, treatment is an umlsterm, supervision is an umlsterm

Psychotherapeut.70420028.eng.abstr_task0

Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .

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[ "umlsterm" ]

Death is an umlsterm, taboos is an umlsterm, society is an umlsterm, medicine is an umlsterm, cause is an umlsterm, uncertainty is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, dying patients is an umlsterm, method is an umlsterm, trauma is an umlsterm, relatives is an umlsterm, doctors is an umlsterm, nurses is an umlsterm, voluntary helpers is an umlsterm, resonance is an umlsterm, elements is an umlsterm, sensitivity is an umlsterm, mood is an umlsterm, fantasy is an umlsterm, method is an umlsterm, treatment is an umlsterm, supervision is an umlsterm

Psychotherapeut.70420028.eng.abstr_task1

Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please typing these entity words according to sentence: Death, taboos, society, medicine, cause, uncertainty, relatives, doctors, nurses, dying patients, method, trauma, relatives, doctors, nurses, voluntary helpers, resonance, elements, sensitivity, mood, fantasy, method, treatment, supervision Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .

[ "Death", "and", "dying", "are", "taboos", "in", "society", "as", "well", "as", "in", "medicine", ".", "Mourning", ",", "despair", ",", "depressive", "crisis", "and", "infantile", "protest", "cause", "uncertainty", "in", "relatives", ",", "doctors", "and", "nurses", ".", "Therefore", ",", "dying", "patients", "are", "left", "alone", ",", "sometimes", "under", "inhumane", "conditions", "and", "without", "dignity", ".", "A", "specific", "method", "is", "described", "which", "allows", "defocussing", "the", "trauma", "of", "dying", "and", "unblocking", "the", "communications", "with", "relatives", ",", "doctors", ",", "nurses", "and", "voluntary", "helpers", ".", "The", "process", "of", "resonance", "with", "its", "elements", "of", "sensitivity", ",", "mood", "and", "fantasy", "is", "the", "centre", "of", "this", "method", "for", "treatment", "and", "supervision", "." ]

[ "umlsterm" ]

Death, taboos, society, medicine, cause, uncertainty, relatives, doctors, nurses, dying patients, method, trauma, relatives, doctors, nurses, voluntary helpers, resonance, elements, sensitivity, mood, fantasy, method, treatment, supervision

Psychotherapeut.70420028.eng.abstr_task2

Sentence: Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Death and dying are taboos in society as well as in medicine . Mourning , despair , depressive crisis and infantile protest cause uncertainty in relatives , doctors and nurses . Therefore , dying patients are left alone , sometimes under inhumane conditions and without dignity . A specific method is described which allows defocussing the trauma of dying and unblocking the communications with relatives , doctors , nurses and voluntary helpers . The process of resonance with its elements of sensitivity , mood and fantasy is the centre of this method for treatment and supervision .

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[ "umlsterm" ]

Previous is a Temporal, antispastic drugs is a Drug, Contraindication is a Condition, baclofen or toxin is a Scope, Antecedent is a Temporal, epileptic seizure is a Condition, Psychiatric is a Condition, antecedent is a Temporal

NCT02462317_exc_task0

Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Temporal, Condition, Drug

[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]

Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent

[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]

[ "Drug", "Scope", "Condition", "Temporal" ]

Previous is a Temporal, antispastic drugs is a Drug, Contraindication is a Condition, baclofen or toxin is a Scope, Antecedent is a Temporal, epileptic seizure is a Condition, Psychiatric is a Condition, antecedent is a Temporal

NCT02462317_exc_task1

Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please typing these entity words according to sentence: Previous, antispastic drugs, Contraindication, baclofen or toxin, Antecedent, epileptic seizure, Psychiatric, antecedent Options: Scope, Temporal, Condition, Drug

[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]

Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent

[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]

[ "Drug", "Scope", "Condition", "Temporal" ]

Previous, antispastic drugs, Contraindication, baclofen or toxin, Antecedent, epileptic seizure, Psychiatric, antecedent

NCT02462317_exc_task2

Sentence: Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent Instructions: please extract entity words from the input sentence

[ "B-Temporal", "B-Drug", "I-Drug", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "O" ]

Previous antispastic drugs Contraindication for baclofen or toxin Antecedent of epileptic seizure Psychiatric antecedent

[ "Previous", "antispastic", "drugs", "\n", "Contraindication", "for", "baclofen", "or", "toxin", "\n", "Antecedent", "of", "epileptic", "seizure", "\n", "Psychiatric", "antecedent", "\n" ]

[ "Drug", "Scope", "Condition", "Temporal" ]

tumor is an umlsterm, surgery is an umlsterm, face is an umlsterm, defects is an umlsterm, retrospective study is an umlsterm, patients is an umlsterm, implants is an umlsterm, mastoid is an umlsterm, implants is an umlsterm, dental implants is an umlsterm, survival is an umlsterm

MundKieferGesichtschirurgie.9003s130.eng.abstr_task0

Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .

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[ "umlsterm" ]

tumor is an umlsterm, surgery is an umlsterm, face is an umlsterm, defects is an umlsterm, retrospective study is an umlsterm, patients is an umlsterm, implants is an umlsterm, mastoid is an umlsterm, implants is an umlsterm, dental implants is an umlsterm, survival is an umlsterm

MundKieferGesichtschirurgie.9003s130.eng.abstr_task1

Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please typing these entity words according to sentence: tumor, surgery, face, defects, retrospective study, patients, implants, mastoid, implants, dental implants, survival Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .

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[ "umlsterm" ]

tumor, surgery, face, defects, retrospective study, patients, implants, mastoid, implants, dental implants, survival

MundKieferGesichtschirurgie.9003s130.eng.abstr_task2

Sentence: Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants . Instructions: please extract entity words from the input sentence

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Endosteal implants after tumor surgery of the face are helpful in reconstructing facial defects . A retrospective study of our patients treated using craniofacial implants was conducted to evaluate long-term results . A total of 128 implants were inserted , 110 implants in the periorbital , 12 implants in the mastoid , and six implants in the paranasal region ; 113 implants were short craniofacial Brånemark implants , and 15 implants were dental implants . The success rate for implant survival was 94.5% . Long-term results were promising and more than satisfactory , leading to a large indication for these endosteal implants .

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[ "umlsterm" ]

Krankengut is an umlsterm, Therapieziel is an umlsterm, Frakturtypen is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Trauma is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Osteoporose is an umlsterm, AO - Klassifikation is an umlsterm, Frakturen is an umlsterm, Operationszeit is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, Standardverfahren is an umlsterm, Frakturen is an umlsterm

DerUnfallchirurg.01030741.ger.abstr_task0

Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .

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[ "umlsterm" ]

Krankengut is an umlsterm, Therapieziel is an umlsterm, Frakturtypen is an umlsterm, Frakturen is an umlsterm, Patienten is an umlsterm, Trauma is an umlsterm, radiologisch is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Osteoporose is an umlsterm, AO - Klassifikation is an umlsterm, Frakturen is an umlsterm, Operationszeit is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Frakturen is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Frakturen is an umlsterm, Standardverfahren is an umlsterm, Frakturen is an umlsterm

DerUnfallchirurg.01030741.ger.abstr_task1

Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please typing these entity words according to sentence: Krankengut, Therapieziel, Frakturtypen, Frakturen, Patienten, Trauma, radiologisch, Patienten, Morbiditaet, Osteoporose, AO - Klassifikation, Frakturen, Operationszeit, Frakturen, Komplikationen, Frakturen, Komplikationen, Patienten, Frakturen, Standardverfahren, Frakturen Options: umlsterm

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Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .

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[ "umlsterm" ]

Krankengut, Therapieziel, Frakturtypen, Frakturen, Patienten, Trauma, radiologisch, Patienten, Morbiditaet, Osteoporose, AO - Klassifikation, Frakturen, Operationszeit, Frakturen, Komplikationen, Frakturen, Komplikationen, Patienten, Frakturen, Standardverfahren, Frakturen

DerUnfallchirurg.01030741.ger.abstr_task2

Sentence: Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden . Instructions: please extract entity words from the input sentence

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Bei der operativen Versorgung petrochantaerer Femurfrakturen im geriatrischen Krankengut stellt eine sofort uebungs- und belastungsstabile Osteosynthese das Therapieziel dar . In einer klinischen Studie wurde vergleichend untersucht , ob dieses Ziel mit der DHS ( dynamische Hueftschraube ) bei allen pertrochantaeren Frakturtypen erreicht werden kann . Von 1994-1996 wurden 122 pertrochantaere Frakturen mit der DHS behandelt . Neben der Auswertung durch standardisierte Datenerhebungsprotokolle wurden die Patienten durchschnittlich 1,9 Jahre nach Trauma radiologisch und klinisch nach dem " Traumatic hip rating score " nachuntersucht 22% ; waren verstorben , von den verbliebenen 95 Patienten konnten 51,6% nachkontrolliert werden . Bei einem Altersdurchschnitt von 75,5 Jahren lag mit dem ASA-Score von durchschnittlich 2,5 Punkten eine hohe praeoperative Morbiditaet vor ; 81% der Faelle wiesen eine fortgeschrittene Osteoporose auf . Nach der AO-Klassifikation handelte es sich um 47% stabile ( Typ A1) und 53% instabile ( Typ A2 und A3) Frakturen . Die mittlere Operationszeit war bei den instabilen im Vergleich zu den stabilen pertrochantaeren Frakturen mit 108 gegenueber 77 min signifikant hoeher , der Blutverlust um 43% groesser . Direkt mit der Osteosynthese assoziierte Komplikationen betrafen ausschliesslich instabile Frakturen ( 7% ) . Allgemeine Komplikationen ( 24,6% ) ueberwogen ebenfalls mit 15,6% in der Gruppe der Typ A2 und A3 gegenueber der Typ-A1-Frakturen, was sich auch in einer entsprechend hoeheren Klinikletalitaet mit 5,7% gegenueber 1,6% ausdrueckt . Bei der Bewertung des funktionellen Nachuntersuchungsergebnisses mit dem THRS wiesen 71% der Patienten im Vergleich zum praeoperativen Ausgangswert eine deutliche Verschlechterung um durchschnittlich 20 Punkte auf . Die Osteosynthese instabiler pertrochantaerer Femurfrakturen durch die DHS ist mit einer hoeheren Komplikationsrate belastet . Waehrend die DHS fuer die stabilen Frakturen das Standardverfahren darstellt muss die Osteosynthese instabiler Frakturen vor dem Hintergrund neuerer operationstechnisch und biomechanisch verbesserter intramedullaerer Implantate , kritisch betrachtet werden .

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[ "umlsterm" ]

IFNα is a GENE-N, IL-22 is a GENE-Y, cytokine is a GENE-N, STAT1 is a GENE-Y

23153456_task0

Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N

[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.

[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

IFNα is a GENE-N, IL-22 is a GENE-Y, cytokine is a GENE-N, STAT1 is a GENE-Y

23153456_task1

Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please typing these entity words according to sentence: IFNα, IL-22, cytokine, STAT1 Options: GENE-Y, GENE-N

[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.

[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

IFNα, IL-22, cytokine, STAT1

23153456_task2

Sentence: IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "O", "B-GENE-Y", "O", "O", "B-GENE-N", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets.

[ "IFNα", "converts", "IL-22", "into", "a", "cytokine", "efficiently", "activating", "STAT1", "and", "its", "downstream", "targets", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

correlation is a Relation_Trigger, miRNAs is a Non-Specific_miRNAs, APP is a Genes/Proteins

8396_task0

Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes/Proteins, Relation_Trigger, Non-Specific_miRNAs

[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.

[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]

correlation is a Relation_Trigger, miRNAs is a Non-Specific_miRNAs, APP is a Genes/Proteins

8396_task1

Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please typing these entity words according to sentence: correlation, miRNAs, APP Options: Genes/Proteins, Relation_Trigger, Non-Specific_miRNAs

[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.

[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]

correlation, miRNAs, APP

8396_task2

Sentence: A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Relation_Trigger", "O", "O", "B-Non-Specific_miRNAs", "O", "B-Genes/Proteins", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons.

[ "A", "tight", "correlation", "between", "these", "miRNAs", "and", "APP", "was", "found", "during", "brain", "development", "and", "in", "differentiating", "neurons", "." ]

[ "Relation_Trigger", "Diseases", "Genes/Proteins", "Specific_miRNAs", "Species", "Non-Specific_miRNAs" ]

Sir2 is a protein, Sir3 is a protein, telomeric C1 - 3A repeats is a DNA, Sir complex is a protein-complex

1.0alpha7.train.915_task0

Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein, protein-complex

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]

Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.

[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]

[ "DNA", "protein-complex", "protein" ]

Sir2 is a protein, Sir3 is a protein, telomeric C1 - 3A repeats is a DNA, Sir complex is a protein-complex

1.0alpha7.train.915_task1

Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please typing these entity words according to sentence: Sir2, Sir3, telomeric C1 - 3A repeats, Sir complex Options: DNA, protein, protein-complex

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]

Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.

[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]

[ "DNA", "protein-complex", "protein" ]

Sir2, Sir3, telomeric C1 - 3A repeats, Sir complex

1.0alpha7.train.915_task2

Sentence: Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "O" ]

Therefore, the binding of Sir2 and Sir3 at 70 bp, 0.5 kb, and 2.4 kb from the telomeric C1-3A repeats is dependent on the presence of the entire Sir complex.

[ "Therefore", ",", "the", "binding", "of", " ", "Sir2", "and", " ", "Sir3", "at", "70", " ", "bp", ",", "0.5", " ", "kb", ",", "and", "2.4", " ", "kb", "from", "the", "telomeric", " ", "C1", "-", "3A", "repeats", "is", "dependent", "on", "the", "presence", "of", "the", "entire", "Sir", "complex", "." ]

[ "DNA", "protein-complex", "protein" ]

T - cell - mediated recognition is an other_name, pml / RAR - alpha hybrid protein is a protein_molecule, lymphocytes is a cell_type, promyelocytic leukemia patients is an other_name

17210_task0

Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_molecule, other_name

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.

[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]

[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]

T - cell - mediated recognition is an other_name, pml / RAR - alpha hybrid protein is a protein_molecule, lymphocytes is a cell_type, promyelocytic leukemia patients is an other_name

17210_task1

Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please typing these entity words according to sentence: T - cell - mediated recognition, pml / RAR - alpha hybrid protein, lymphocytes, promyelocytic leukemia patients Options: cell_type, protein_molecule, other_name

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.

[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]

[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]

T - cell - mediated recognition, pml / RAR - alpha hybrid protein, lymphocytes, promyelocytic leukemia patients

17210_task2

Sentence: Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-cell_type", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.

[ "Lack", "of", "T", "-", "cell", "-", "mediated", "recognition", "of", "the", "fusion", "region", "of", "the", "pml", "/", "RAR", "-", "alpha", "hybrid", "protein", "by", "lymphocytes", "of", "acute", "promyelocytic", "leukemia", "patients", "." ]

[ "protein_molecule", "cell_line", "other_name", "cell_type", "peptide", "protein_family_or_group", "multi_cell" ]

Fra-1 is a Protein, cJun is a Protein, JunD is a Protein, JunB is a Protein, JunB is a Protein

8428966_task0

Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.

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[ "Protein" ]

Fra-1 is a Protein, cJun is a Protein, JunD is a Protein, JunB is a Protein, JunB is a Protein

8428966_task1

Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please typing these entity words according to sentence: Fra-1, cJun, JunD, JunB, JunB Options: Protein

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Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.

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[ "Protein" ]

Fra-1, cJun, JunD, JunB, JunB

8428966_task2

Sentence: Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms. Instructions: please extract entity words from the input sentence

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Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor. Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex. Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos). We further characterize which AP1 family members can assume this role. Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1. Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone. Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component. NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes. Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex. Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.

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[ "Protein" ]

Pasireotide is a CHEMICAL

23605695_task0

Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pasireotide: A Review of Its Use in Cushing's Disease.

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[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Pasireotide is a CHEMICAL

23605695_task1

Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please typing these entity words according to sentence: Pasireotide Options: CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pasireotide: A Review of Its Use in Cushing's Disease.

[ "Pasireotide", ":", "A", "Review", "of", "Its", "Use", "in", "Cushing", "'s", "Disease", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Pasireotide

23605695_task2

Sentence: Pasireotide: A Review of Its Use in Cushing's Disease. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pasireotide: A Review of Its Use in Cushing's Disease.

[ "Pasireotide", ":", "A", "Review", "of", "Its", "Use", "in", "Cushing", "'s", "Disease", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Acanthosis nigricans is an umlsterm, etiology is an umlsterm, hyperpigmentation is an umlsterm, skin is an umlsterm, development is an umlsterm, Malignant is an umlsterm, acanthosis nigricans is an umlsterm, adenocarcinoma is an umlsterm, time is an umlsterm, diagnosis is an umlsterm, association is an umlsterm, acanthosis nigricans is an umlsterm, transitional cell carcinoma is an umlsterm, urinary bladder is an umlsterm, treatment is an umlsterm, calcipotriol is an umlsterm, skin is an umlsterm

DerHautarzt.90500593.eng.abstr_task0

Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .

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[ "umlsterm" ]

Acanthosis nigricans is an umlsterm, etiology is an umlsterm, hyperpigmentation is an umlsterm, skin is an umlsterm, development is an umlsterm, Malignant is an umlsterm, acanthosis nigricans is an umlsterm, adenocarcinoma is an umlsterm, time is an umlsterm, diagnosis is an umlsterm, association is an umlsterm, acanthosis nigricans is an umlsterm, transitional cell carcinoma is an umlsterm, urinary bladder is an umlsterm, treatment is an umlsterm, calcipotriol is an umlsterm, skin is an umlsterm

DerHautarzt.90500593.eng.abstr_task1

Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please typing these entity words according to sentence: Acanthosis nigricans, etiology, hyperpigmentation, skin, development, Malignant, acanthosis nigricans, adenocarcinoma, time, diagnosis, association, acanthosis nigricans, transitional cell carcinoma, urinary bladder, treatment, calcipotriol, skin Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .

[ "Acanthosis", "nigricans", "is", "a", "hyperkeratotic", "mucocutaneous", "eruption", "of", "heterogenous", "etiology", "which", "is", "characterized", "by", "hyperpigmentation", ",", "velvety", "cutaneous", "thickening", ",", "intensified", "skin", "markings", "and", "development", "of", "verrucous", "excrescences", "typically", "involving", "the", "intertriginous", "areas", ".", "Malignant", "acanthosis", "nigricans", "is", "most", "often", "associated", "with", "an", "abdominal", "adenocarcinoma", "frequently", "unresectable", "at", "the", "time", "of", "diagnosis", ".", "We", "report", "on", "the", "rare", "association", "of", "acanthosis", "nigricans", "with", "a", "transitional", "cell", "carcinoma", "of", "the", "urinary", "bladder", ".", "Symptomatic", "treatment", "with", "topical", "calcipotriol", "significantly", "reduced", "the", "hyperkeratotic", "and", "papillomatous", "skin", "changes", "." ]

[ "umlsterm" ]

Acanthosis nigricans, etiology, hyperpigmentation, skin, development, Malignant, acanthosis nigricans, adenocarcinoma, time, diagnosis, association, acanthosis nigricans, transitional cell carcinoma, urinary bladder, treatment, calcipotriol, skin

DerHautarzt.90500593.eng.abstr_task2

Sentence: Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes .

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[ "umlsterm" ]

ecstasy is a Chemicals & Drugs

7512_task0

Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Chemicals & Drugs

[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.

[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]

[ "Diseases & Disorders", "", "Chemicals & Drugs" ]

ecstasy is a Chemicals & Drugs

7512_task1

Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please typing these entity words according to sentence: ecstasy Options: Chemicals & Drugs

[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.

[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]

[ "Diseases & Disorders", "", "Chemicals & Drugs" ]

ecstasy

7512_task2

Sentence: Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-Chemicals & Drugs", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study.

[ "Cognitive", "performance", "in", "recreational", "ecstasy", "polydrug", "users", ":", "a", "two", "-", "year", "follow", "-", "up", "study", "." ]

[ "Diseases & Disorders", "", "Chemicals & Drugs" ]

tyrosine phosphorylation is an other_name, endothelial adhesion molecule induction is an other_name

33339_task0

Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name

[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.

[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]

[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]

tyrosine phosphorylation is an other_name, endothelial adhesion molecule induction is an other_name

33339_task1

Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please typing these entity words according to sentence: tyrosine phosphorylation, endothelial adhesion molecule induction Options: other_name

[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.

[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]

[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]

tyrosine phosphorylation, endothelial adhesion molecule induction

33339_task2

Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-other_name", "I-other_name", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.

[ "Involvement", "of", "tyrosine", "phosphorylation", "in", "endothelial", "adhesion", "molecule", "induction", "." ]

[ "other_name", "protein_molecule", "protein_family_or_group", "protein_complex", "cell_type", "other_organic_compound", "RNA_molecule", "amino_acid_monomer" ]

symptoms is an umlsterm, disorder is an umlsterm, attention is an umlsterm, spatial perception is an umlsterm, optic is an umlsterm, ataxia is an umlsterm, reading is an umlsterm, orientation is an umlsterm, movement is an umlsterm, element is an umlsterm, review is an umlsterm, etiology is an umlsterm, disorders is an umlsterm, Instructions is an umlsterm, patients is an umlsterm, treatment is an umlsterm, attention is an umlsterm, syndrome is an umlsterm, paper is an umlsterm

DerNervenarzt.90700859.eng.abstr_task0

Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .

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[ "umlsterm" ]

symptoms is an umlsterm, disorder is an umlsterm, attention is an umlsterm, spatial perception is an umlsterm, optic is an umlsterm, ataxia is an umlsterm, reading is an umlsterm, orientation is an umlsterm, movement is an umlsterm, element is an umlsterm, review is an umlsterm, etiology is an umlsterm, disorders is an umlsterm, Instructions is an umlsterm, patients is an umlsterm, treatment is an umlsterm, attention is an umlsterm, syndrome is an umlsterm, paper is an umlsterm

DerNervenarzt.90700859.eng.abstr_task1

Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please typing these entity words according to sentence: symptoms, disorder, attention, spatial perception, optic, ataxia, reading, orientation, movement, element, review, etiology, disorders, Instructions, patients, treatment, attention, syndrome, paper Options: umlsterm

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Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .

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[ "umlsterm" ]

symptoms, disorder, attention, spatial perception, optic, ataxia, reading, orientation, movement, element, review, etiology, disorders, Instructions, patients, treatment, attention, syndrome, paper

DerNervenarzt.90700859.eng.abstr_task2

Sentence: Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Balint syndrom is a combination of symptoms including simultanagnosia , a disorder of spatial and object-based attention , disturbed spatial perception and representation , and optic ataxia resulting from bilateral parieto-occipital lesions . Fixation and ocular exploration of space are severely impaired , as are reading , writing , drawing and orientation as well as movement in space . Low-level visual impairments may be associated and difficult to evaluate but are not a necessary element of Balint syndrom . This review summarizes the relevant facts of the etiology , localization of lesions , and the core features as well as frequently associated disorders of the syndrom . Instructions for the examination of patients are given and approaches for the management and treatment outlined . Models of attention and space representation are described for the explanation of this multifaceted and exciting syndrome . Finally the key features of the syndrom are summarized in a table at the end of the paper .

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[ "umlsterm" ]

literature is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, hypersensitivity is an umlsterm, sugar beet is an umlsterm, disease is an umlsterm, man is an umlsterm, history is an umlsterm, atopic dermatitis is an umlsterm, contact dermatitis is an umlsterm, rhinitis is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, job is an umlsterm, seed is an umlsterm, nursery is an umlsterm

DerHautarzt.60470462.eng.abstr_task0

Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .

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[ "umlsterm" ]

literature is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, hypersensitivity is an umlsterm, sugar beet is an umlsterm, disease is an umlsterm, man is an umlsterm, history is an umlsterm, atopic dermatitis is an umlsterm, contact dermatitis is an umlsterm, rhinitis is an umlsterm, sugar beet is an umlsterm, pollen is an umlsterm, job is an umlsterm, seed is an umlsterm, nursery is an umlsterm

DerHautarzt.60470462.eng.abstr_task1

Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please typing these entity words according to sentence: literature, sugar beet, pollen, hypersensitivity, sugar beet, disease, man, history, atopic dermatitis, contact dermatitis, rhinitis, sugar beet, pollen, job, seed, nursery Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .

[ "Although", "there", "are", "a", "few", "isolated", "reports", "in", "the", "literature", "suggesting", "that", "sugar", "beet", "pollen", "is", "highly", "antigenic", ",", "hypersensitivity", "to", "components", "of", "sugar", "beet", "is", "not", "a", "common", "disease", ".", "We", "report", "a", "29-year", "-", "old", "man", "with", "a", "history", "of", "atopic", "dermatitis", "who", "developed", "both", "contact", "dermatitis", "and", "allergic", "rhinitis", "from", "sugar", "beet", "pollen", "through", "his", "job", "in", "a", "seed", "nursery", "." ]

[ "umlsterm" ]

literature, sugar beet, pollen, hypersensitivity, sugar beet, disease, man, history, atopic dermatitis, contact dermatitis, rhinitis, sugar beet, pollen, job, seed, nursery

DerHautarzt.60470462.eng.abstr_task2

Sentence: Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

Although there are a few isolated reports in the literature suggesting that sugar beet pollen is highly antigenic , hypersensitivity to components of sugar beet is not a common disease . We report a 29-year-old man with a history of atopic dermatitis who developed both contact dermatitis and allergic rhinitis from sugar beet pollen through his job in a seed nursery .

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[ "umlsterm" ]

p.[D448H;H294Q ] is a SNP, D409H is a SNP

584_task0

Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: SNP

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.

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[ "SNP" ]

p.[D448H;H294Q ] is a SNP, D409H is a SNP

584_task1

Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please typing these entity words according to sentence: p.[D448H;H294Q ], D409H Options: SNP

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "I-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-SNP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.

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[ "SNP" ]

p.[D448H;H294Q ], D409H

584_task2

Sentence: Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele. Instructions: please extract entity words from the input sentence

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Haplotype analysis suggests a single Balkan origin for the Gaucher disease [D409H;H255Q] double mutant allele. Gaucher disease is an autosomal recessive lysosomal storage disease that is mainly due to mutations in the GBA gene. Most of the mutant alleles described so far bear a single mutation. However, there are a few alleles bearing two or more DNA changes. It has been reported that patients homozygous for the [D409H;H255Q] double mutant allele (HGVS-approved nomenclature, p.[D448H;H294Q]) present a more severe phenotype than patients homozygous for the relatively common D409H mutation. In this study, we confirmed the detrimental cumulative effect of these two mutations at the enzymatic activity level by the heterologous expression of the single and double mutant alleles. Additionally, we found a high frequency of the [D409H;H255Q] allele in patients from the Balkans and the Adriatic area of Italy. This prompted us to perform a haplotype analysis, using five microsatellite polymorphisms close to the GBA gene, to determine the origin of this allele. The results of the 37 chromosomes analysed showed that most of them share a common haplotype and are consistent with a single origin in the Balkans and the Adriatic area of Italy for the [D409H;H255Q] allele.

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[ "SNP" ]

tumor necrosis factor alpha is a Protein, interleukin-3 is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein

169_task0

Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.

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[ "Protein" ]

tumor necrosis factor alpha is a Protein, interleukin-3 is a Protein, granulocyte - macrophage colony - stimulating factor is a Protein

169_task1

Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please typing these entity words according to sentence: tumor necrosis factor alpha, interleukin-3, granulocyte - macrophage colony - stimulating factor Options: Protein

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An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.

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[ "Protein" ]

tumor necrosis factor alpha, interleukin-3, granulocyte - macrophage colony - stimulating factor

169_task2

Sentence: An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution. Instructions: please extract entity words from the input sentence

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An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.

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[ "Protein" ]

CD43 is a protein, T cell is a cell, T cell is a cell, APC membrane is an organelle

1.0alpha7.train.1179_task0

Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell, protein, organelle

[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).

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[ "organelle", "cell", "protein" ]

CD43 is a protein, T cell is a cell, T cell is a cell, APC membrane is an organelle

1.0alpha7.train.1179_task1

Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please typing these entity words according to sentence: CD43, T cell, T cell, APC membrane Options: cell, protein, organelle

[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).

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[ "organelle", "cell", "protein" ]

CD43, T cell, T cell, APC membrane

1.0alpha7.train.1179_task2

Sentence: Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "O", "B-organelle", "I-organelle", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Some studies have suggested that CD43 acts as an inhibitor of T cell activation, possibly because its large size and high negative charge (Cyster et al., 1991) might interfere with close binding of the T cell and APC membrane (Manjunath et al., 1995).

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[ "organelle", "cell", "protein" ]

adaptations is an umlsterm, human is an umlsterm, pregnancy is an umlsterm, ovulation is an umlsterm, heart rate is an umlsterm, blood pressure is an umlsterm, stroke volume is an umlsterm, cardiac output is an umlsterm, peripheral resistance is an umlsterm, compliance is an umlsterm, standard is an umlsterm, menstrual cycle is an umlsterm, conception is an umlsterm, conception is an umlsterm, Techniques is an umlsterm, EKG is an umlsterm, blood pressure is an umlsterm, measurement is an umlsterm, plethysmography is an umlsterm, conception is an umlsterm, conception is an umlsterm, time is an umlsterm, human chorionic gonadotropin is an umlsterm, estradiol is an umlsterm, progesterone is an umlsterm

DerGynaekologe.90320360.eng.abstr_task0

Sentence: To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu .

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[ "umlsterm" ]

adaptations is an umlsterm, human is an umlsterm, pregnancy is an umlsterm, ovulation is an umlsterm, heart rate is an umlsterm, blood pressure is an umlsterm, stroke volume is an umlsterm, cardiac output is an umlsterm, peripheral resistance is an umlsterm, compliance is an umlsterm, standard is an umlsterm, menstrual cycle is an umlsterm, conception is an umlsterm, conception is an umlsterm, Techniques is an umlsterm, EKG is an umlsterm, blood pressure is an umlsterm, measurement is an umlsterm, plethysmography is an umlsterm, conception is an umlsterm, conception is an umlsterm, time is an umlsterm, human chorionic gonadotropin is an umlsterm, estradiol is an umlsterm, progesterone is an umlsterm

DerGynaekologe.90320360.eng.abstr_task1

Sentence: To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu . Instructions: please typing these entity words according to sentence: adaptations, human, pregnancy, ovulation, heart rate, blood pressure, stroke volume, cardiac output, peripheral resistance, compliance, standard, menstrual cycle, conception, conception, Techniques, EKG, blood pressure, measurement, plethysmography, conception, conception, time, human chorionic gonadotropin, estradiol, progesterone Options: umlsterm

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To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu .

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[ "umlsterm" ]