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Pedro, Iglesias Pastor, 1149404, 343551107164, A Coruña, 15003, 09/05/1945, España, 67 años, 02/04/2013, 1287103, José Manuel Janeiro Pais, 15 15 65203, Varón, 67 años, José Manuel Janeiro Pais, Avda . Lázaro Cárdenas , 23 - 1ºE, 15009, La Coruña, España, janeiropais@canalejo.org
185_task2
Sentence: Datos del paciente. Nombre: Pedro . Apellidos: Iglesias Pastor. NHC: 1149404. NASS: 343551107164. Domicilio: Rúa Comandante Fontanes, 19, 2 B. Localidad/ Provincia: A Coruña. CP: 15003. Datos asistenciales. Fecha de nacimiento: 09/05/1945. País de nacimiento: España. Edad: 67 años Sexo: H. Fecha de Ingreso: 02/04/2013. Episodio: 1287103. Médico: José Manuel Janeiro Pais NºCol: 15 15 65203. Informe clínico del paciente: Varón, de 67 años, con agudeza visual de 0,6 y 0,5 con cataratas nucleares grado 3 en ambos ojos. El ojo izquierdo mostraba un pterigión nasal grado I y diversas lesiones con forma de islotes corneales epiteliales con distribución semicircular inferior, no afectando al eje visual. No presentaba signos inflamatorios en el segmento anterior y el resto de la exploración es normal. Se instauró tratamiento con Mitomicina-C 0,02% preoperatorio (1), con reducción de la lesión a 1/3 de su tamaño. Se realizó intervención de cataratas en ambos ojos mediante técnica MICS, exéresis del pterigión del ojo izquierdo y exéresis de la lesión corneal, remitiéndose a estudio anatomopatológico, el cual informa: epitelio conjuntival con focos de atipia leve de las células de la capa basal, llegando a ocupar la atipia, a nivel del limbo, hasta 2/3 del espesor total, observándose escaso pleomorfismo. Degeneración elastótica actínica del corión y escaso infiltrado inflamatorio crónico linfocitario subepitelial. A los 6 meses se evidenció la presencia de islotes aislados recidivantes, tratándose nuevamente con Mitomicina-C, regresando la lesión, no evidenciándose nuevas recidivas en su seguimiento durante 1 año. Responsable clínico: Dr. José Manuel Janeiro Pais, Avda. Lázaro Cárdenas, 23 - 1ºE 15009 La Coruña (España). janeiropais@canalejo.org Instructions: please extract entity words from the input sentence
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Datos del paciente. Nombre: Pedro . Apellidos: Iglesias Pastor. NHC: 1149404. NASS: 343551107164. Domicilio: Rúa Comandante Fontanes, 19, 2 B. Localidad/ Provincia: A Coruña. CP: 15003. Datos asistenciales. Fecha de nacimiento: 09/05/1945. País de nacimiento: España. Edad: 67 años Sexo: H. Fecha de Ingreso: 02/04/2013. Episodio: 1287103. Médico: José Manuel Janeiro Pais NºCol: 15 15 65203. Informe clínico del paciente: Varón, de 67 años, con agudeza visual de 0,6 y 0,5 con cataratas nucleares grado 3 en ambos ojos. El ojo izquierdo mostraba un pterigión nasal grado I y diversas lesiones con forma de islotes corneales epiteliales con distribución semicircular inferior, no afectando al eje visual. No presentaba signos inflamatorios en el segmento anterior y el resto de la exploración es normal. Se instauró tratamiento con Mitomicina-C 0,02% preoperatorio (1), con reducción de la lesión a 1/3 de su tamaño. Se realizó intervención de cataratas en ambos ojos mediante técnica MICS, exéresis del pterigión del ojo izquierdo y exéresis de la lesión corneal, remitiéndose a estudio anatomopatológico, el cual informa: epitelio conjuntival con focos de atipia leve de las células de la capa basal, llegando a ocupar la atipia, a nivel del limbo, hasta 2/3 del espesor total, observándose escaso pleomorfismo. Degeneración elastótica actínica del corión y escaso infiltrado inflamatorio crónico linfocitario subepitelial. A los 6 meses se evidenció la presencia de islotes aislados recidivantes, tratándose nuevamente con Mitomicina-C, regresando la lesión, no evidenciándose nuevas recidivas en su seguimiento durante 1 año. Responsable clínico: Dr. José Manuel Janeiro Pais, Avda. Lázaro Cárdenas, 23 - 1ºE 15009 La Coruña (España). janeiropais@canalejo.org
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Abstract is an umlsterm, Surgery is an umlsterm, veins is an umlsterm, surgical treatment is an umlsterm, injuries is an umlsterm, femoral vein is an umlsterm, ligation is an umlsterm, vein is an umlsterm, death is an umlsterm, vein is an umlsterm, femoral artery is an umlsterm, ligation is an umlsterm, veins is an umlsterm, limbs is an umlsterm, sepsis is an umlsterm, suppurative is an umlsterm, surgical is an umlsterm, method is an umlsterm, patients is an umlsterm, appendicitis is an umlsterm, puerperal is an umlsterm, fever is an umlsterm, limb is an umlsterm, vein is an umlsterm, surgical treatment is an umlsterm, leg is an umlsterm, deep vein thrombosis is an umlsterm, thrombectomy is an umlsterm, operations is an umlsterm, Society is an umlsterm, Surgery is an umlsterm
DerChirurg.00710337.eng.abstr_task0
Sentence: Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year .
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Abstract is an umlsterm, Surgery is an umlsterm, veins is an umlsterm, surgical treatment is an umlsterm, injuries is an umlsterm, femoral vein is an umlsterm, ligation is an umlsterm, vein is an umlsterm, death is an umlsterm, vein is an umlsterm, femoral artery is an umlsterm, ligation is an umlsterm, veins is an umlsterm, limbs is an umlsterm, sepsis is an umlsterm, suppurative is an umlsterm, surgical is an umlsterm, method is an umlsterm, patients is an umlsterm, appendicitis is an umlsterm, puerperal is an umlsterm, fever is an umlsterm, limb is an umlsterm, vein is an umlsterm, surgical treatment is an umlsterm, leg is an umlsterm, deep vein thrombosis is an umlsterm, thrombectomy is an umlsterm, operations is an umlsterm, Society is an umlsterm, Surgery is an umlsterm
DerChirurg.00710337.eng.abstr_task1
Sentence: Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year . Instructions: please typing these entity words according to sentence: Abstract, Surgery, veins, surgical treatment, injuries, femoral vein, ligation, vein, death, vein, femoral artery, ligation, veins, limbs, sepsis, suppurative, surgical, method, patients, appendicitis, puerperal, fever, limb, vein, surgical treatment, leg, deep vein thrombosis, thrombectomy, operations, Society, Surgery Options: umlsterm
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Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year .
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[ "umlsterm" ]
Abstract, Surgery, veins, surgical treatment, injuries, femoral vein, ligation, vein, death, vein, femoral artery, ligation, veins, limbs, sepsis, suppurative, surgical, method, patients, appendicitis, puerperal, fever, limb, vein, surgical treatment, leg, deep vein thrombosis, thrombectomy, operations, Society, Surgery
DerChirurg.00710337.eng.abstr_task2
Sentence: Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year . Instructions: please extract entity words from the input sentence
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Abstract . Surgery of the great veins inevitably began with the surgical treatment of injuries , often involving the femoral vein . Because of the famous case presented by Roux in 1813 , the prevailing opinion until almost the end of the nineteenth century was that ligation of the vein made death inevitable , but that the only way to control severe hemorrhaging from a vein was to ligate the femoral artery . Zaufal's principle ( 1880 ) consisted in the ligation and resection of great veins of the body and limbs in order to prevent sepsis in suppurative processes . This surgical method was still being used in the first half of the twentieth century in patients with perforated appendicitis or puerperal fever . In the limb , the congestion induced in the vein had a positve effect on the healing process . The surgical treatment of leg and pelvic deep vein thrombosis was initially ( 1931 ) aimed at achieving decompression in compartment syndromas . The first thrombectomy was performed in 1937 , but several operations with a successful outcome were reported at the 61st annual meeting of the German Society of Surgery in the following year .
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[ "umlsterm" ]
alpha - galactosidase A gene is a Gene, GLA is a Gene, E48 K is a SNP, c.142G > A is a SNP, W81S is a SNP, c.242G > C is a SNP, D170H is a SNP, c.508G > C is a SNP, W226C is a SNP, c.678G > T is a SNP, Q279R is a SNP, c.836A > G is a SNP, C382Y is a SNP, c.1145G > A is a SNP, I407 K is a SNP, c.1220T > A is a SNP, L414S is a SNP, c.1241T > C is a SNP, W95X is a SNP, c.284G > A is a SNP, Y216fsX15 is a SNP, c.646_647insT is a SNP, G346fsX1 is a SNP, c.1037delG is a SNP, K426fsX23 is a SNP, c.1277_1278delAA is a SNP, A368fsX24 is a SNP, c.1102delGinsTTATAC is a SNP, IVS4 + 1G > A is a SNP, c.639 + 1G > A is a SNP, Q279R is a SNP
538_task0
Sentence: Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP
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Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment.
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[ "Gene", "SNP" ]
alpha - galactosidase A gene is a Gene, GLA is a Gene, E48 K is a SNP, c.142G > A is a SNP, W81S is a SNP, c.242G > C is a SNP, D170H is a SNP, c.508G > C is a SNP, W226C is a SNP, c.678G > T is a SNP, Q279R is a SNP, c.836A > G is a SNP, C382Y is a SNP, c.1145G > A is a SNP, I407 K is a SNP, c.1220T > A is a SNP, L414S is a SNP, c.1241T > C is a SNP, W95X is a SNP, c.284G > A is a SNP, Y216fsX15 is a SNP, c.646_647insT is a SNP, G346fsX1 is a SNP, c.1037delG is a SNP, K426fsX23 is a SNP, c.1277_1278delAA is a SNP, A368fsX24 is a SNP, c.1102delGinsTTATAC is a SNP, IVS4 + 1G > A is a SNP, c.639 + 1G > A is a SNP, Q279R is a SNP
538_task1
Sentence: Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment. Instructions: please typing these entity words according to sentence: alpha - galactosidase A gene, GLA, E48 K, c.142G > A, W81S, c.242G > C, D170H, c.508G > C, W226C, c.678G > T, Q279R, c.836A > G, C382Y, c.1145G > A, I407 K, c.1220T > A, L414S, c.1241T > C, W95X, c.284G > A, Y216fsX15, c.646_647insT, G346fsX1, c.1037delG, K426fsX23, c.1277_1278delAA, A368fsX24, c.1102delGinsTTATAC, IVS4 + 1G > A, c.639 + 1G > A, Q279R Options: Gene, SNP
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Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment.
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[ "Gene", "SNP" ]
alpha - galactosidase A gene, GLA, E48 K, c.142G > A, W81S, c.242G > C, D170H, c.508G > C, W226C, c.678G > T, Q279R, c.836A > G, C382Y, c.1145G > A, I407 K, c.1220T > A, L414S, c.1241T > C, W95X, c.284G > A, Y216fsX15, c.646_647insT, G346fsX1, c.1037delG, K426fsX23, c.1277_1278delAA, A368fsX24, c.1102delGinsTTATAC, IVS4 + 1G > A, c.639 + 1G > A, Q279R
538_task2
Sentence: Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment. Instructions: please extract entity words from the input sentence
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Molecular analysis in Fabry disease in Spain: fifteen novel GLA mutations and identification of a homozygous female. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene (GLA). Here we report molecular studies in 22 unrelated Spanish patients with Fabry disease ( 20 males and two females). Fifteen novel mutations were identified. In addition 7 previously described mutations and two previously reported polymorphisms were detected. The 15 novel mutations comprise: eight missense E48K (c.142G>A), W81S (c.242G>C), D170H (c.508G>C), W226C (c.678G>T), Q279R (c.836A>G), C382Y (c.1145G>A), I407K (c.1220T>A), L414S (c.1241T>C); one nonsense W95X (c.284G>A); one insertion Y216fsX15 (c.646_647insT); two small deletions G346fsX1 (c.1037delG), K426fsX23 (c.1277_1278delAA); one gross deletion comprising exons 5, 6, 7; one complex mutation (insertion and deletion) A368fsX24 (c.1102delGinsTTATAC), and one splice-site mutation IVS4+1G>A (c.639+1G>A). One of the females was found homozygous for Q279R mutation and she presented with the classic phenotype since the age of 8 years, this case extending into women the severe phenotype observed in classically affected males. Mutation analysis provided precise identification for 30 heterozygotes among female relatives and detection of a de novo mutation. The molecular studies on Spanish Fabry patients here reported further contribute to the identification of new mutations in this disease, and allow reliable detection of heterozygotes which has consequences for genetic counselling and for treatment.
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[ "Gene", "SNP" ]
Sauerstoffverbrauch is an umlsterm, Blutfluss is an umlsterm, Autoregulation is an umlsterm, Hirngefaesse is an umlsterm, Gefaesswiderstands is an umlsterm, intrakraniellen Drucks is an umlsterm, Hyperventilation is an umlsterm, Anaesthetika is an umlsterm, Erholung is an umlsterm, Anaesthesie is an umlsterm, Isofluran is an umlsterm, krampfausloesende is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Neurochirurgie is an umlsterm, Karotischirurgie is an umlsterm
DerAnaesthesist.8047s037.ger.abstr_task0
Sentence: Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet .
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[ "umlsterm" ]
Sauerstoffverbrauch is an umlsterm, Blutfluss is an umlsterm, Autoregulation is an umlsterm, Hirngefaesse is an umlsterm, Gefaesswiderstands is an umlsterm, intrakraniellen Drucks is an umlsterm, Hyperventilation is an umlsterm, Anaesthetika is an umlsterm, Erholung is an umlsterm, Anaesthesie is an umlsterm, Isofluran is an umlsterm, krampfausloesende is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Neurochirurgie is an umlsterm, Karotischirurgie is an umlsterm
DerAnaesthesist.8047s037.ger.abstr_task1
Sentence: Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet . Instructions: please typing these entity words according to sentence: Sauerstoffverbrauch, Blutfluss, Autoregulation, Hirngefaesse, Gefaesswiderstands, intrakraniellen Drucks, Hyperventilation, Anaesthetika, Erholung, Anaesthesie, Isofluran, krampfausloesende, Isofluran, Patienten, Neurochirurgie, Karotischirurgie Options: umlsterm
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Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet .
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[ "umlsterm" ]
Sauerstoffverbrauch, Blutfluss, Autoregulation, Hirngefaesse, Gefaesswiderstands, intrakraniellen Drucks, Hyperventilation, Anaesthetika, Erholung, Anaesthesie, Isofluran, krampfausloesende, Isofluran, Patienten, Neurochirurgie, Karotischirurgie
DerAnaesthesist.8047s037.ger.abstr_task2
Sentence: Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet . Instructions: please extract entity words from the input sentence
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Sevofluran ( 1 MAC ) senkt den zerebralen Sauerstoffverbrauch um ca. 50% . Unter Sevofluran ist der zerebrale Blutfluss konstant oder nur gering vermindert Autoregulation und CO2-Reagibilitaet , der Hirngefaesse bleiben erhalten . In Folge der Abnahme des zerebrovaskulaeren Gefaesswiderstands unter Sevofluran kommt es zu geringen dosisabhaengigen Anstiegen des intrakraniellen Drucks , die waehrend Hyperventilation nicht zu beobachten sind . Sevofluran bewirkt eine dosisabhaengige Blockade der zentralen Reizverarbeitung , des Elektroenzephalogramms und des reizevozierten EEG-Signals in aehnlichem Masse wie andere volatile Anaesthetika . Die elektrophysiologischen Befunde legen nahe , dass Dosierungen von Sevofluran von 1,5-2,0 Vol . % intraoperative Wachphaenomene im allgemeinen zuverlaessig unterdruecken . Die Erholung kognitiver und psychomotorischer Funktionen scheint nach Anaesthesie mit Sevofluran im Vergleich zu Isofluran schneller und vollstaendiger zu erfolgen . Das krampfausloesende Potential von Sevofluran kann als gering und am ehesten dem Isofluran entsprechend eingestuft werden . Sevofluran kann auch bei Patienten mit psychiatrischen oder neurologischen Begleiterkrankungen als unbedenklich eingestuft werden . In der Neurochirurgie sowie in der Karotischirurgie wird der Stellenwert von Sevofluran als positiv bewertet .
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[ "umlsterm" ]
Alopezie is an umlsterm, Haarwachstum is an umlsterm, DNS - Flowzytometrie is an umlsterm, Kopfhautbiopsien is an umlsterm
DerHautarzt.40450360.ger.abstr_task0
Sentence: Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen .
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[ "umlsterm" ]
Alopezie is an umlsterm, Haarwachstum is an umlsterm, DNS - Flowzytometrie is an umlsterm, Kopfhautbiopsien is an umlsterm
DerHautarzt.40450360.ger.abstr_task1
Sentence: Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen . Instructions: please typing these entity words according to sentence: Alopezie, Haarwachstum, DNS - Flowzytometrie, Kopfhautbiopsien Options: umlsterm
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Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen .
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[ "umlsterm" ]
Alopezie, Haarwachstum, DNS - Flowzytometrie, Kopfhautbiopsien
DerHautarzt.40450360.ger.abstr_task2
Sentence: Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Haarwuchsmittel sollen bei der androgenetischen Alopezie die Regression des Terminalhaarfollikels zum Miniaturfollikel stoppen bzw. umkehren , so dass sich die zunehmende Verkuerzung der Haarzyklen - insbesondere die Anagenphasendauer - wieder stabilisiert und hierdurch ein laengerer zeitlicher Haarerhalt erreicht wird . Allerdings erlaubt die haeufig als Argument fuer Wirksamkeit von Haarwuchsmitteln posttherapeutisch nachgewiesene Zunahme der Anagenhaarrate im Trichogramm nicht ohne weitere Parameter die Schlussfolgerung , dass durch die Anwendung eines Haarwuchsmittels auch eine Verlaengerung oder zumindest Stabilisierung der Anagenphasendauer erreicht wurde . Denn auch eine Verkuerzung der Telogenphase kann bei Konstanz oder sogar relativer Verringerung der Anagenphasendauer zu einer Erhoehung der Anagenrate fuehren . Da therapeutisches Haarwachstum immer auf einer Aenderung der proliferativen Aktivitaet des Haarfollikels beruht , sollte die Wirkung von Haarwuchsmitteln primaer auf zellkinetischer Ebene untersucht werden . Hierzu bietet sich die DNS-Flowzytometrie als ein genaues Verfahren an , um therapeutische Effekte auf das Proliferationsverhalten sowohl epilierter Anagenhaare ( bulbusnahes Segment ) wie auch aus Kopfhautbiopsien mikropraeparativ isolierter kompletter Anagenhaarfollikel an groesseren Probandenkollektiven rasch und sicher zu erfassen .
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[ "umlsterm" ]
halogen is a CHEMICAL, mono- , bi- , and tri - dentate anion receptors is a GENE-N
23591590_task0
Sentence: Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD.
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[ "GENE-N", "CHEMICAL" ]
halogen is a CHEMICAL, mono- , bi- , and tri - dentate anion receptors is a GENE-N
23591590_task1
Sentence: Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD. Instructions: please typing these entity words according to sentence: halogen, mono- , bi- , and tri - dentate anion receptors Options: GENE-N, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD.
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[ "GENE-N", "CHEMICAL" ]
halogen, mono- , bi- , and tri - dentate anion receptors
23591590_task2
Sentence: Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD.
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[ "GENE-N", "CHEMICAL" ]
Patienten is an umlsterm, psychiatrische Krankenhaus is an umlsterm, Patienten is an umlsterm, Personalbesetzung is an umlsterm, Patienten is an umlsterm
DerNervenarzt.70680245.ger.abstr_task0
Sentence: Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden .
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[ "umlsterm" ]
Patienten is an umlsterm, psychiatrische Krankenhaus is an umlsterm, Patienten is an umlsterm, Personalbesetzung is an umlsterm, Patienten is an umlsterm
DerNervenarzt.70680245.ger.abstr_task1
Sentence: Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden . Instructions: please typing these entity words according to sentence: Patienten, psychiatrische Krankenhaus, Patienten, Personalbesetzung, Patienten Options: umlsterm
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Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden .
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[ "umlsterm" ]
Patienten, psychiatrische Krankenhaus, Patienten, Personalbesetzung, Patienten
DerNervenarzt.70680245.ger.abstr_task2
Sentence: Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden . Instructions: please extract entity words from the input sentence
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Die Untersuchung liefert empirische Daten zum Vergleich verschiedener Systeme zur stationaeren Aufnahme von Patienten in das psychiatrische Krankenhaus . In der psychiatrischen Universitaetsklinik Basel wurde anstatt der bisherigen Aufnahme von Patienten ueber eine zentrale Aufnahmestation eine dezentrale Aufnahme auf verschiedenen Behandlungsstationen eingefuehrt . Diese Strukturveraenderung hatte verschiedene Auswirkungen auf die Struktur- und Prozessqualitaet . Es erfolgten mehr angemeldete Eintritte , und diese fanden haeufiger zu Tageszeiten statt , in denen die Personalbesetzung guenstiger ist . Die Rate freiwilliger Aufnahmen war erhoeht und die Betreuungskontinuitaet , gemessen an der Anzahl der Verlegungen im Haus in den ersten 5 Tagen nach der Aufnahme , verbessert . Diesen Variablen , die fuer eine Verbesserung der Versorgungssitutation sprechen , stehen v. a. verlaengerte Entscheidungsprozesse mit z . B. verlaengerten Wartezeiten als Nachteile fuer die Patienten entgegen . Die Beziehungskontinuitaet kann durch weitere Veraenderungen der Prozessqualitaet noch erhoeht werden .
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[ "umlsterm" ]
TNF - alpha is a Protein
317_task0
Sentence: Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.
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[ "Protein" ]
TNF - alpha is a Protein
317_task1
Sentence: Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B. Instructions: please typing these entity words according to sentence: TNF - alpha Options: Protein
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.
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[ "Protein" ]
TNF - alpha
317_task2
Sentence: Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B. Instructions: please extract entity words from the input sentence
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line. The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin. This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.
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[ "Protein" ]
Behandlung is an umlsterm, rheumatoiden Arthritis is an umlsterm, Entzuendung is an umlsterm, Zellen is an umlsterm, Behandlung is an umlsterm, Verlaufsbeobachtung is an umlsterm, Patienten is an umlsterm
DerOrthopaede.80270160.ger.abstr_task0
Sentence: In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten .
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[ "umlsterm" ]
Behandlung is an umlsterm, rheumatoiden Arthritis is an umlsterm, Entzuendung is an umlsterm, Zellen is an umlsterm, Behandlung is an umlsterm, Verlaufsbeobachtung is an umlsterm, Patienten is an umlsterm
DerOrthopaede.80270160.ger.abstr_task1
Sentence: In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten . Instructions: please typing these entity words according to sentence: Behandlung, rheumatoiden Arthritis, Entzuendung, Zellen, Behandlung, Verlaufsbeobachtung, Patienten Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten .
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[ "umlsterm" ]
Behandlung, rheumatoiden Arthritis, Entzuendung, Zellen, Behandlung, Verlaufsbeobachtung, Patienten
DerOrthopaede.80270160.ger.abstr_task2
Sentence: In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten . Instructions: please extract entity words from the input sentence
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In der Behandlung der rheumatoiden Arthritis , die haeufigste unter den entzuendlich-rheumatischen Systemerkrankungen , sind in den letzten Jahren zahlreiche Fortschritte erzielt worden . Die Behandlungsstrategie stuetzt sich einerseits auf die sogenannten prognostischen Faktoren , andererseits auf das Ausmass der Entzuendung , v. a. in der Fruehphase . Zahlreiche kontrollierte Studien wie auch Metaanalysen ermoeglichen ein optimales Einsetzen unter Beruecksichtigung des Wirkungs-/Nebenwirkungsprofils der Basistherapeutika . In der Fruehphase der Erkrankung werden zusehends immunbiologische , gegen die proinflammatorischen Zellen gerichtete Substanzen eingesetzt . Neue Erkenntnisse der physiotherapeutischen Behandlung , der Ernaehrungsberatung und Verlaufsbeobachtung ermoeglichen eine optimale Betreuung dieser Patienten .
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Iker is a NOMBRE_SUJETO_ASISTENCIA, Iparraguirre Rodrigo is a NOMBRE_SUJETO_ASISTENCIA, 5679386 is a ID_SUJETO_ASISTENCIA, 34 07895698 67 is a ID_ASEGURAMIENTO, Bilbao is a TERRITORIO, 48551 is a TERRITORIO, 21/03/1998 is a FECHAS, España is a PAIS, 20 años is a EDAD_SUJETO_ASISTENCIA, 09/06/2018 is a FECHAS, Begoña Biritxinaga is a NOMBRE_PERSONAL_SANITARIO, 48 48 55941 is a ID_TITULACION_PERSONAL_SANITARIO, Varón is a SEXO_SUJETO_ASISTENCIA, joven is a ID_SUJETO_ASISTENCIA, 20 años is a EDAD_SUJETO_ASISTENCIA, 6 años is a EDAD_SUJETO_ASISTENCIA, Begoña Biritxinaga is a NOMBRE_PERSONAL_SANITARIO, Instituto Vasco de Medicina Legal is a INSTITUCION, c/ Barroeta Aldamar 10 is a CALLE, 48001 is a TERRITORIO, Bilbao is a TERRITORIO, biritxinaga.b@AJU.ej-gv.es is a CORREO_ELECTRONICO
402_task0
Sentence: Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO
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Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es
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402_task1
Sentence: Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es Instructions: please typing these entity words according to sentence: Iker, Iparraguirre Rodrigo, 5679386, 34 07895698 67, Bilbao, 48551, 21/03/1998, España, 20 años, 09/06/2018, Begoña Biritxinaga, 48 48 55941, Varón, joven, 20 años, 6 años, Begoña Biritxinaga, Instituto Vasco de Medicina Legal, c/ Barroeta Aldamar 10, 48001, Bilbao, biritxinaga.b@AJU.ej-gv.es Options: TERRITORIO, SEXO_SUJETO_ASISTENCIA, ID_SUJETO_ASISTENCIA, FECHAS, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_ASEGURAMIENTO, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO
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Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es
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Iker, Iparraguirre Rodrigo, 5679386, 34 07895698 67, Bilbao, 48551, 21/03/1998, España, 20 años, 09/06/2018, Begoña Biritxinaga, 48 48 55941, Varón, joven, 20 años, 6 años, Begoña Biritxinaga, Instituto Vasco de Medicina Legal, c/ Barroeta Aldamar 10, 48001, Bilbao, biritxinaga.b@AJU.ej-gv.es
402_task2
Sentence: Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es Instructions: please extract entity words from the input sentence
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Datos del paciente. Nombre: Iker. Apellidos: Iparraguirre Rodrigo. NHC: 5679386. NASS: 34 07895698 67. Domicilio: Calle Amara, 23, 4D. Localidad/ Provincia: Bilbao. CP: 48551. Datos asistenciales. Fecha de nacimiento: 21/03/1998. País de nacimiento: España. Edad: 20 años Sexo: H. Fecha de Ingreso: 09/06/2018. Médico: Begoña Biritxinaga NºCol: 48 48 55941. Informe clínico del paciente: Varón joven de 20 años, con antecedentes desde los 6 años de crisis epilépticas parciales con generalización y mal control medicamentoso (en el momento de su fallecimiento estaba en tratamiento con oxcarbazepina), que fallece de forma súbita e inesperada durante el sueño. Durante su control neurológico se le habían realizado estudios de imagen de tomografía computarizada (TC) y resonancia magnética (RM) que no habían mostrado alteraciones reseñables. Se le realiza una autopsia médico-legal para esclarecer la causa de la muerte. En el estudio neuropatológico destaca el encéfalo con un peso de 1.545 gramos en el que se evidencia un área parduzca de 0,5 x 1 cm en la corteza cerebral del lóbulo parietal izquierdo, que no presenta efecto masa. El estudio histopatológico evidencia un tumor que exhibe características histopatológicas distintivas, constituidas por elementos glioneuronales heterogéneos que contienen células oligodendrocito-like y neuronas flotantes inmersas en un fluido intersticial mixoide de apariencia microquística. Se determinan marcadores inmunohistoquímicos para la proteína glial fibrilar ácida (GFAP) y para marcadores neuronales (enolasa, neurofilamentos y sinaptofisina) que fueron todos ellos positivos. A la vista de estos hallazgos se establece el diagnóstico de TDN simple. El resto de órganos estudiados no presenta alteraciones morfológicas (macroscópicas ni microscópicas) destacables. El análisis químico-toxicológico realizado resulta negativo para los tóxicos analizados. Responsable clínico: Begoña Biritxinaga Instituto Vasco de Medicina Legal c/ Barroeta Aldamar 10, 48001 Bilbao E-mail: biritxinaga.b@AJU.ej-gv.es
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[ "INSTITUCION", "CORREO_ELECTRONICO", "CALLE", "NOMBRE_SUJETO_ASISTENCIA", "NOMBRE_PERSONAL_SANITARIO", "ID_ASEGURAMIENTO", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "EDAD_SUJETO_ASISTENCIA", "ID_SUJETO_ASISTENCIA", "TERRITORIO", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
non - Native is an umlsterm, prurigo is an umlsterm, prurigo is an umlsterm, old is an umlsterm, prurigo - like is an umlsterm, development is an umlsterm, HLA typing is an umlsterm, association is an umlsterm, Treatment is an umlsterm, patient is an umlsterm
DerHautarzt.00510597.eng.abstr_task0
Sentence: The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection .
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[ "umlsterm" ]
non - Native is an umlsterm, prurigo is an umlsterm, prurigo is an umlsterm, old is an umlsterm, prurigo - like is an umlsterm, development is an umlsterm, HLA typing is an umlsterm, association is an umlsterm, Treatment is an umlsterm, patient is an umlsterm
DerHautarzt.00510597.eng.abstr_task1
Sentence: The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection . Instructions: please typing these entity words according to sentence: non - Native, prurigo, prurigo, old, prurigo - like, development, HLA typing, association, Treatment, patient Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection .
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[ "umlsterm" ]
non - Native, prurigo, prurigo, old, prurigo - like, development, HLA typing, association, Treatment, patient
DerHautarzt.00510597.eng.abstr_task2
Sentence: The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection .
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[ "umlsterm" ]
B29 ( immunoglobulin beta - chain ) gene is a DNA_domain_or_region, early B - cell factor is a protein_molecule
49123_task0
Sentence: The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, protein_molecule
[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O" ]
The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor.
[ "The", "B29", "(", "immunoglobulin", "beta", "-", "chain", ")", "gene", "is", "a", "genetic", "target", "for", "early", "B", "-", "cell", "factor", "." ]
[ "DNA_molecule", "DNA_domain_or_region", "other_name", "protein_subunit", "protein_family_or_group", "protein_molecule", "other_artificial_source", "RNA_family_or_group", "cell_type", "cell_line", "body_part" ]
B29 ( immunoglobulin beta - chain ) gene is a DNA_domain_or_region, early B - cell factor is a protein_molecule
49123_task1
Sentence: The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor. Instructions: please typing these entity words according to sentence: B29 ( immunoglobulin beta - chain ) gene, early B - cell factor Options: DNA_domain_or_region, protein_molecule
[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O" ]
The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor.
[ "The", "B29", "(", "immunoglobulin", "beta", "-", "chain", ")", "gene", "is", "a", "genetic", "target", "for", "early", "B", "-", "cell", "factor", "." ]
[ "DNA_molecule", "DNA_domain_or_region", "other_name", "protein_subunit", "protein_family_or_group", "protein_molecule", "other_artificial_source", "RNA_family_or_group", "cell_type", "cell_line", "body_part" ]
B29 ( immunoglobulin beta - chain ) gene, early B - cell factor
49123_task2
Sentence: The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor. Instructions: please extract entity words from the input sentence
[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O" ]
The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor.
[ "The", "B29", "(", "immunoglobulin", "beta", "-", "chain", ")", "gene", "is", "a", "genetic", "target", "for", "early", "B", "-", "cell", "factor", "." ]
[ "DNA_molecule", "DNA_domain_or_region", "other_name", "protein_subunit", "protein_family_or_group", "protein_molecule", "other_artificial_source", "RNA_family_or_group", "cell_type", "cell_line", "body_part" ]
objective is an umlsterm, Information Network is an umlsterm, Dermatology is an umlsterm, patch tests is an umlsterm, Contact Dermatitis is an umlsterm, Research is an umlsterm, patients is an umlsterm, testing is an umlsterm, otitis externa is an umlsterm
DerHautarzt.00510239.eng.abstr_task0
Sentence: Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]
Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed .
[ "Background", "and", "objective", ".", "The", "Information", "Network", "of", "Departments", "of", "Dermatology", "(", "IVDK", ")", "centrally", "collects", "patch", "tests", "results", "in", "cooperation", "with", "the", "German", "Contact", "Dermatitis", "Research", "Group", "(", "DKG", ")", ".", "Data", "of", "patients", ",", "who", "underwent", "patch", "testing", "to", "evaluate", "otitis", "externa", "were", "analyzed", "." ]
[ "umlsterm" ]
objective is an umlsterm, Information Network is an umlsterm, Dermatology is an umlsterm, patch tests is an umlsterm, Contact Dermatitis is an umlsterm, Research is an umlsterm, patients is an umlsterm, testing is an umlsterm, otitis externa is an umlsterm
DerHautarzt.00510239.eng.abstr_task1
Sentence: Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed . Instructions: please typing these entity words according to sentence: objective, Information Network, Dermatology, patch tests, Contact Dermatitis, Research, patients, testing, otitis externa Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]
Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed .
[ "Background", "and", "objective", ".", "The", "Information", "Network", "of", "Departments", "of", "Dermatology", "(", "IVDK", ")", "centrally", "collects", "patch", "tests", "results", "in", "cooperation", "with", "the", "German", "Contact", "Dermatitis", "Research", "Group", "(", "DKG", ")", ".", "Data", "of", "patients", ",", "who", "underwent", "patch", "testing", "to", "evaluate", "otitis", "externa", "were", "analyzed", "." ]
[ "umlsterm" ]
objective, Information Network, Dermatology, patch tests, Contact Dermatitis, Research, patients, testing, otitis externa
DerHautarzt.00510239.eng.abstr_task2
Sentence: Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]
Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed .
[ "Background", "and", "objective", ".", "The", "Information", "Network", "of", "Departments", "of", "Dermatology", "(", "IVDK", ")", "centrally", "collects", "patch", "tests", "results", "in", "cooperation", "with", "the", "German", "Contact", "Dermatitis", "Research", "Group", "(", "DKG", ")", ".", "Data", "of", "patients", ",", "who", "underwent", "patch", "testing", "to", "evaluate", "otitis", "externa", "were", "analyzed", "." ]
[ "umlsterm" ]
neutrophils is a Cell, polymorphonuclear granulocytes is a Cell, neutrophils is a Cell, tumor is a Pathological_formation, neutrophils is a Cell, reactive oxygen species is a Drug_or_compound, ROS is a Drug_or_compound, neutrophil is a Cell, neutrophils is a Cell, neutrophils is a Cell, tumor is a Pathological_formation, tumor is a Pathological_formation, neutrophil is a Cell, ROS is a Drug_or_compound
52_task0
Sentence: [Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Drug_or_compound, Cell
[ "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Drug_or_compound", "I-Drug_or_compound", "I-Drug_or_compound", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity.
[ "[", "Ambiguity", "role", "of", "neutrophils", "in", "oncogenesis", "]", "\n\n", "The", "review", "is", "focused", "on", "the", "participation", "of", "polymorphonuclear", "granulocytes", "(", "neutrophils", ")", "in", "development", "and", "spreading", "of", "a", "tumor", ".", "We", "consider", "both", "the", "well", "known", "functions", "of", "neutrophils", "(", "degranulation", ",", "production", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ")", "and", "the", "recently", "shown", "one", "(", "presentation", "of", "an", "antigene", ")", ".", "The", "special", "attention", "is", "focused", "on", "the", "ambiguity", "of", "the", "neutrophil", "role", "in", "oncogenesis", ".", "The", "dominant", "view", "is", "that", "neutrophils", "display", "exclusively", "antitumor", "properties", ".", "The", "update", "information", "testifies", "about", "protumoral", "activity", "of", "neutrophils", ":", "they", "migrate", "to", "a", "tumor", "and", "promote", "angiogenesis", "and", "metastasis", "at", "late", "stages", "of", "the", "tumor", ".", "It", "is", "interesting", "that", "certain", "components", "of", "neutrophil", "cytotoxic", "arsenal", "(", "ROS", ",", "cytokines", ",", "specific", "enzymes", ")", "participate", "both", "in", "antitumoral", "defenses", "of", "an", "organism", "and", "protumoral", "activity", ".", "\n" ]
[ "Cell", "Drug_or_compound", "Pathological_formation" ]
neutrophils is a Cell, polymorphonuclear granulocytes is a Cell, neutrophils is a Cell, tumor is a Pathological_formation, neutrophils is a Cell, reactive oxygen species is a Drug_or_compound, ROS is a Drug_or_compound, neutrophil is a Cell, neutrophils is a Cell, neutrophils is a Cell, tumor is a Pathological_formation, tumor is a Pathological_formation, neutrophil is a Cell, ROS is a Drug_or_compound
52_task1
Sentence: [Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity. Instructions: please typing these entity words according to sentence: neutrophils, polymorphonuclear granulocytes, neutrophils, tumor, neutrophils, reactive oxygen species, ROS, neutrophil, neutrophils, neutrophils, tumor, tumor, neutrophil, ROS Options: Pathological_formation, Drug_or_compound, Cell
[ "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Drug_or_compound", "I-Drug_or_compound", "I-Drug_or_compound", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity.
[ "[", "Ambiguity", "role", "of", "neutrophils", "in", "oncogenesis", "]", "\n\n", "The", "review", "is", "focused", "on", "the", "participation", "of", "polymorphonuclear", "granulocytes", "(", "neutrophils", ")", "in", "development", "and", "spreading", "of", "a", "tumor", ".", "We", "consider", "both", "the", "well", "known", "functions", "of", "neutrophils", "(", "degranulation", ",", "production", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ")", "and", "the", "recently", "shown", "one", "(", "presentation", "of", "an", "antigene", ")", ".", "The", "special", "attention", "is", "focused", "on", "the", "ambiguity", "of", "the", "neutrophil", "role", "in", "oncogenesis", ".", "The", "dominant", "view", "is", "that", "neutrophils", "display", "exclusively", "antitumor", "properties", ".", "The", "update", "information", "testifies", "about", "protumoral", "activity", "of", "neutrophils", ":", "they", "migrate", "to", "a", "tumor", "and", "promote", "angiogenesis", "and", "metastasis", "at", "late", "stages", "of", "the", "tumor", ".", "It", "is", "interesting", "that", "certain", "components", "of", "neutrophil", "cytotoxic", "arsenal", "(", "ROS", ",", "cytokines", ",", "specific", "enzymes", ")", "participate", "both", "in", "antitumoral", "defenses", "of", "an", "organism", "and", "protumoral", "activity", ".", "\n" ]
[ "Cell", "Drug_or_compound", "Pathological_formation" ]
neutrophils, polymorphonuclear granulocytes, neutrophils, tumor, neutrophils, reactive oxygen species, ROS, neutrophil, neutrophils, neutrophils, tumor, tumor, neutrophil, ROS
52_task2
Sentence: [Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Drug_or_compound", "I-Drug_or_compound", "I-Drug_or_compound", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "B-Drug_or_compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[Ambiguity role of neutrophils in oncogenesis] The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity.
[ "[", "Ambiguity", "role", "of", "neutrophils", "in", "oncogenesis", "]", "\n\n", "The", "review", "is", "focused", "on", "the", "participation", "of", "polymorphonuclear", "granulocytes", "(", "neutrophils", ")", "in", "development", "and", "spreading", "of", "a", "tumor", ".", "We", "consider", "both", "the", "well", "known", "functions", "of", "neutrophils", "(", "degranulation", ",", "production", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ")", "and", "the", "recently", "shown", "one", "(", "presentation", "of", "an", "antigene", ")", ".", "The", "special", "attention", "is", "focused", "on", "the", "ambiguity", "of", "the", "neutrophil", "role", "in", "oncogenesis", ".", "The", "dominant", "view", "is", "that", "neutrophils", "display", "exclusively", "antitumor", "properties", ".", "The", "update", "information", "testifies", "about", "protumoral", "activity", "of", "neutrophils", ":", "they", "migrate", "to", "a", "tumor", "and", "promote", "angiogenesis", "and", "metastasis", "at", "late", "stages", "of", "the", "tumor", ".", "It", "is", "interesting", "that", "certain", "components", "of", "neutrophil", "cytotoxic", "arsenal", "(", "ROS", ",", "cytokines", ",", "specific", "enzymes", ")", "participate", "both", "in", "antitumoral", "defenses", "of", "an", "organism", "and", "protumoral", "activity", ".", "\n" ]
[ "Cell", "Drug_or_compound", "Pathological_formation" ]
Amylin is a GENE-Y, AMY is a GENE-Y, amylin is a GENE-Y, CT ( calcitonin ) receptor is a GENE-Y, RAMP is a GENE-N, receptor activity modifying protein is a GENE-N, AMY(1(a ) ) is a GENE-N, AMY(2(a ) ) is a GENE-N, AMY(3(a ) ) is a GENE-N, CT receptor is a GENE-Y, ( CT((a ) ) ) is a GENE-Y, RAMP1 is a GENE-Y, RAMP2 is a GENE-Y, RAMP3 is a GENE-Y
17784_task0
Sentence: Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N
[ "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.
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[ "GENE-N", "GENE-Y" ]
Amylin is a GENE-Y, AMY is a GENE-Y, amylin is a GENE-Y, CT ( calcitonin ) receptor is a GENE-Y, RAMP is a GENE-N, receptor activity modifying protein is a GENE-N, AMY(1(a ) ) is a GENE-N, AMY(2(a ) ) is a GENE-N, AMY(3(a ) ) is a GENE-N, CT receptor is a GENE-Y, ( CT((a ) ) ) is a GENE-Y, RAMP1 is a GENE-Y, RAMP2 is a GENE-Y, RAMP3 is a GENE-Y
17784_task1
Sentence: Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed. Instructions: please typing these entity words according to sentence: Amylin, AMY, amylin, CT ( calcitonin ) receptor, RAMP, receptor activity modifying protein, AMY(1(a ) ), AMY(2(a ) ), AMY(3(a ) ), CT receptor, ( CT((a ) ) ), RAMP1, RAMP2, RAMP3 Options: GENE-Y, GENE-N
[ "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.
[ "Amylin", "receptors", ":", "molecular", "composition", "and", "pharmacology", ".", "\n", "Several", "receptors", "which", "bind", "the", "hormone", "AMY", "(", "amylin", ")", "with", "high", "affinity", "have", "now", "been", "identified", ".", "The", "minimum", "binding", "unit", "is", "composed", "of", "the", "CT", "(", "calcitonin", ")", "receptor", "at", "its", "core", ",", "plus", "a", "RAMP", "(", "receptor", "activity", "modifying", "protein", ")", ".", "The", "receptors", "have", "been", "named", "AMY(1(a", ")", ")", ",", "AMY(2(a", ")", ")", "and", "AMY(3(a", ")", ")", "in", "accordance", "with", "the", "association", "of", "the", "CT", "receptor", "(", "CT((a", ")", ")", ")", "with", "RAMP1", ",", "RAMP2", "and", "RAMP3", "respectively", ".", "The", "challenge", "is", "now", "to", "determine", "the", "localization", "and", "pharmacological", "nature", "of", "each", "of", "these", "receptors", ".", "Recent", "attempts", "to", "achieve", "these", "aims", "will", "be", "briefly", "discussed", "." ]
[ "GENE-N", "GENE-Y" ]
Amylin, AMY, amylin, CT ( calcitonin ) receptor, RAMP, receptor activity modifying protein, AMY(1(a ) ), AMY(2(a ) ), AMY(3(a ) ), CT receptor, ( CT((a ) ) ), RAMP1, RAMP2, RAMP3
17784_task2
Sentence: Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed. Instructions: please extract entity words from the input sentence
[ "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Amylin receptors: molecular composition and pharmacology. Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.
[ "Amylin", "receptors", ":", "molecular", "composition", "and", "pharmacology", ".", "\n", "Several", "receptors", "which", "bind", "the", "hormone", "AMY", "(", "amylin", ")", "with", "high", "affinity", "have", "now", "been", "identified", ".", "The", "minimum", "binding", "unit", "is", "composed", "of", "the", "CT", "(", "calcitonin", ")", "receptor", "at", "its", "core", ",", "plus", "a", "RAMP", "(", "receptor", "activity", "modifying", "protein", ")", ".", "The", "receptors", "have", "been", "named", "AMY(1(a", ")", ")", ",", "AMY(2(a", ")", ")", "and", "AMY(3(a", ")", ")", "in", "accordance", "with", "the", "association", "of", "the", "CT", "receptor", "(", "CT((a", ")", ")", ")", "with", "RAMP1", ",", "RAMP2", "and", "RAMP3", "respectively", ".", "The", "challenge", "is", "now", "to", "determine", "the", "localization", "and", "pharmacological", "nature", "of", "each", "of", "these", "receptors", ".", "Recent", "attempts", "to", "achieve", "these", "aims", "will", "be", "briefly", "discussed", "." ]
[ "GENE-N", "GENE-Y" ]
male is an umlsterm, patients is an umlsterm, diagnosis is an umlsterm, urethritis is an umlsterm, Dermatology is an umlsterm, Military Hospital is an umlsterm, patients is an umlsterm, age is an umlsterm, diagnostic is an umlsterm, procedure is an umlsterm
DerHautarzt.90500186.eng.abstr_task0
Sentence: 545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ... Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]
545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ...
[ "545", "male", "patients", "with", "a", "tentative", "diagnosis", "\"", "urethritis", "\"", "were", "examined", "between", "November", "1984", "and", "December", "1994", "in", "the", "Department", "of", "Dermatology", "and", "Venerology", "of", "the", "Military", "Hospital", "in", "Ulm", ".", "The", "patients", ",", "aged", "from", "18", "to", "58", "years", "(", "mean", "age", "24.1", "years", ")", ",", "were", "examined", "according", "to", "a", "standardized", "diagnostic", "procedure", ":", "..." ]
[ "umlsterm" ]
male is an umlsterm, patients is an umlsterm, diagnosis is an umlsterm, urethritis is an umlsterm, Dermatology is an umlsterm, Military Hospital is an umlsterm, patients is an umlsterm, age is an umlsterm, diagnostic is an umlsterm, procedure is an umlsterm
DerHautarzt.90500186.eng.abstr_task1
Sentence: 545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ... Instructions: please typing these entity words according to sentence: male, patients, diagnosis, urethritis, Dermatology, Military Hospital, patients, age, diagnostic, procedure Options: umlsterm
[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]
545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ...
[ "545", "male", "patients", "with", "a", "tentative", "diagnosis", "\"", "urethritis", "\"", "were", "examined", "between", "November", "1984", "and", "December", "1994", "in", "the", "Department", "of", "Dermatology", "and", "Venerology", "of", "the", "Military", "Hospital", "in", "Ulm", ".", "The", "patients", ",", "aged", "from", "18", "to", "58", "years", "(", "mean", "age", "24.1", "years", ")", ",", "were", "examined", "according", "to", "a", "standardized", "diagnostic", "procedure", ":", "..." ]
[ "umlsterm" ]
male, patients, diagnosis, urethritis, Dermatology, Military Hospital, patients, age, diagnostic, procedure
DerHautarzt.90500186.eng.abstr_task2
Sentence: 545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ... Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]
545 male patients with a tentative diagnosis " urethritis " were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ...
[ "545", "male", "patients", "with", "a", "tentative", "diagnosis", "\"", "urethritis", "\"", "were", "examined", "between", "November", "1984", "and", "December", "1994", "in", "the", "Department", "of", "Dermatology", "and", "Venerology", "of", "the", "Military", "Hospital", "in", "Ulm", ".", "The", "patients", ",", "aged", "from", "18", "to", "58", "years", "(", "mean", "age", "24.1", "years", ")", ",", "were", "examined", "according", "to", "a", "standardized", "diagnostic", "procedure", ":", "..." ]
[ "umlsterm" ]
HMGB1 is a protein, butyrate is a compound
DS.d669_task0
Sentence: Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells.
[ "Here", ",", "we", "have", "investigated", "how", "the", "post", "-", "synthetic", "acetylation", "of", "HMGB1", "affects", "its", "interaction", "with", "negatively", "supercoiled", "DNA", "by", "employing", "monoacetylated", "at", "Lys2", "protein", ",", "isolated", "from", "butyrate", "-", "treated", "cells", "." ]
[ "compound", "protein" ]
HMGB1 is a protein, butyrate is a compound
DS.d669_task1
Sentence: Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells. Instructions: please typing these entity words according to sentence: HMGB1, butyrate Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells.
[ "Here", ",", "we", "have", "investigated", "how", "the", "post", "-", "synthetic", "acetylation", "of", "HMGB1", "affects", "its", "interaction", "with", "negatively", "supercoiled", "DNA", "by", "employing", "monoacetylated", "at", "Lys2", "protein", ",", "isolated", "from", "butyrate", "-", "treated", "cells", "." ]
[ "compound", "protein" ]
HMGB1, butyrate
DS.d669_task2
Sentence: Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells.
[ "Here", ",", "we", "have", "investigated", "how", "the", "post", "-", "synthetic", "acetylation", "of", "HMGB1", "affects", "its", "interaction", "with", "negatively", "supercoiled", "DNA", "by", "employing", "monoacetylated", "at", "Lys2", "protein", ",", "isolated", "from", "butyrate", "-", "treated", "cells", "." ]
[ "compound", "protein" ]
notch-1 is a protein_molecule, TCR - induced apoptosis is an other_name
51572_task0
Sentence: Protective effects of notch-1 on TCR-induced apoptosis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name, protein_molecule
[ "O", "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Protective effects of notch-1 on TCR-induced apoptosis.
[ "Protective", "effects", "of", "notch-1", "on", "TCR", "-", "induced", "apoptosis", "." ]
[ "other_name", "protein_molecule", "multi_cell", "cell_line", "cell_type", "mono_cell", "protein_family_or_group" ]
notch-1 is a protein_molecule, TCR - induced apoptosis is an other_name
51572_task1
Sentence: Protective effects of notch-1 on TCR-induced apoptosis. Instructions: please typing these entity words according to sentence: notch-1, TCR - induced apoptosis Options: other_name, protein_molecule
[ "O", "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Protective effects of notch-1 on TCR-induced apoptosis.
[ "Protective", "effects", "of", "notch-1", "on", "TCR", "-", "induced", "apoptosis", "." ]
[ "other_name", "protein_molecule", "multi_cell", "cell_line", "cell_type", "mono_cell", "protein_family_or_group" ]
notch-1, TCR - induced apoptosis
51572_task2
Sentence: Protective effects of notch-1 on TCR-induced apoptosis. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-protein_molecule", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]
Protective effects of notch-1 on TCR-induced apoptosis.
[ "Protective", "effects", "of", "notch-1", "on", "TCR", "-", "induced", "apoptosis", "." ]
[ "other_name", "protein_molecule", "multi_cell", "cell_line", "cell_type", "mono_cell", "protein_family_or_group" ]
Hirnrindenentwicklung is an umlsterm, Anfallsleiden is an umlsterm, Nomenklatur is an umlsterm, Klassifikation is an umlsterm, Literatur is an umlsterm, Magnetresonanztomographie is an umlsterm, Prognose is an umlsterm, Therapieoptionen is an umlsterm, Anfallsleiden is an umlsterm, epilepsiechirurgischen is an umlsterm, Klassifikation is an umlsterm, Routinediagnostik is an umlsterm, Techniken is an umlsterm, Diagnose is an umlsterm
DerNervenarzt.00710616.ger.abstr_task0
Sentence: Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen .
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[ "umlsterm" ]
Hirnrindenentwicklung is an umlsterm, Anfallsleiden is an umlsterm, Nomenklatur is an umlsterm, Klassifikation is an umlsterm, Literatur is an umlsterm, Magnetresonanztomographie is an umlsterm, Prognose is an umlsterm, Therapieoptionen is an umlsterm, Anfallsleiden is an umlsterm, epilepsiechirurgischen is an umlsterm, Klassifikation is an umlsterm, Routinediagnostik is an umlsterm, Techniken is an umlsterm, Diagnose is an umlsterm
DerNervenarzt.00710616.ger.abstr_task1
Sentence: Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen . Instructions: please typing these entity words according to sentence: Hirnrindenentwicklung, Anfallsleiden, Nomenklatur, Klassifikation, Literatur, Magnetresonanztomographie, Prognose, Therapieoptionen, Anfallsleiden, epilepsiechirurgischen, Klassifikation, Routinediagnostik, Techniken, Diagnose Options: umlsterm
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Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen .
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[ "umlsterm" ]
Hirnrindenentwicklung, Anfallsleiden, Nomenklatur, Klassifikation, Literatur, Magnetresonanztomographie, Prognose, Therapieoptionen, Anfallsleiden, epilepsiechirurgischen, Klassifikation, Routinediagnostik, Techniken, Diagnose
DerNervenarzt.00710616.ger.abstr_task2
Sentence: Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen . Instructions: please extract entity words from the input sentence
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Kortikale Dysgenesien umfassen eine heterogene Gruppe von Stoerungen der Hirnrindenentwicklung , die durch die Fortschritte der modernen bildgebenden Verfahren immer haeufiger bei verschiedenen Krankheitsbildern diagnostiziert werden . Das Spektrum der Krankheitsmanifestationen reicht dabei je nach Typ und Ausmass der Veraenderungen von schweren mentalen Retardierungen ueber epileptische Anfallsleiden bis hin zu isolierten neuropsychologischen Defiziten und psychiatrischen Erkrankungen . Die Nomenklatur kortikaler Dysgenesien , sowohl nach morphologischen als auch pathologischen Gesichtspunkten , war bislang uneinheitlich . Das Verstaendnis und die Einordnung dieser vielfaeltigen Texturstoerungen ist allerdings durch eine neu vorgeschlagene Klassifikation , die sich an pathophysiologischen und pathogenetischen Aspekten orientiert , wesentlich erleichtert worden . Diese neue Einteilung wurde von einem internationalen Expertengremium erarbeitet und ist bislang in der deutschsprachigen Literatur wenig bekannt . Die Magnetresonanztomographie ermoeglicht es , einen grossen Teil der Dysgenesien bereits zu Lebzeiten zu erkennen und zu klassifizieren , so dass die Prognose und Therapieoptionen abgewogen werden koennen . Von besonderer Bedeutung ist das fruehzeitige Erkennen von kortikalen Malformationen bei medikamentoes nicht beherrschbaren Anfallsleiden , da diese durch einen epilepsiechirurgischen Eingriff gemildert oder sogar geheilt werden koennen . Der vorliegende Artikel stellt die wichtigsten kortikalen Dysgenesien anhand der neuen Klassifikation vor und beschreibt die klinischen sowie die bildmorphologischen Charakteristika . Neben in der klinischen Routinediagnostik eingesetzten magnetresonanztomographischen Techniken werden experimentelle Verfahren beschrieben , die bei der Diagnose auch von diskreten Veraenderungen helfen koennen .
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[ "umlsterm" ]
estrogen is a GROUP, contraceptives is a GROUP, estrogen is a GROUP, antithrombin 3 is a DRUG
Dienestrol_ddi_task0
Sentence: Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG
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Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration.
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[ "GROUP", "DRUG" ]
estrogen is a GROUP, contraceptives is a GROUP, estrogen is a GROUP, antithrombin 3 is a DRUG
Dienestrol_ddi_task1
Sentence: Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration. Instructions: please typing these entity words according to sentence: estrogen, contraceptives, estrogen, antithrombin 3 Options: GROUP, DRUG
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Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration.
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[ "GROUP", "DRUG" ]
estrogen, contraceptives, estrogen, antithrombin 3
Dienestrol_ddi_task2
Sentence: Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration. Instructions: please extract entity words from the input sentence
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Drug/ Laboratory Test Interactions Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen: - Increased sulfobromophthalein retention . - Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability . - Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered . - Impaired glucose tolerance . - Decreased pregnanediol excretion . - Reduced response to metyrapone test . - Reduced serum folate concentration . - Increased serum triglyceride and phospholipid concentration.
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[ "GROUP", "DRUG" ]
Stage is a Measurement, 3 - 5 is a Value, Chronic Kidney Disease is a Condition
NCT02364648_inc_task0
Sentence: Stage 3 - 5 Chronic Kidney Disease Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Measurement, Value
[ "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O" ]
Stage 3 - 5 Chronic Kidney Disease
[ "Stage", "3", "-", "5", "Chronic", "Kidney", "Disease", "\n" ]
[ "Condition", "Measurement", "Value" ]
Stage is a Measurement, 3 - 5 is a Value, Chronic Kidney Disease is a Condition
NCT02364648_inc_task1
Sentence: Stage 3 - 5 Chronic Kidney Disease Instructions: please typing these entity words according to sentence: Stage, 3 - 5, Chronic Kidney Disease Options: Condition, Measurement, Value
[ "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O" ]
Stage 3 - 5 Chronic Kidney Disease
[ "Stage", "3", "-", "5", "Chronic", "Kidney", "Disease", "\n" ]
[ "Condition", "Measurement", "Value" ]
Stage, 3 - 5, Chronic Kidney Disease
NCT02364648_inc_task2
Sentence: Stage 3 - 5 Chronic Kidney Disease Instructions: please extract entity words from the input sentence
[ "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O" ]
Stage 3 - 5 Chronic Kidney Disease
[ "Stage", "3", "-", "5", "Chronic", "Kidney", "Disease", "\n" ]
[ "Condition", "Measurement", "Value" ]
cyclophosphamide is a Intervention_Pharmacological, methylprednisolone is a Intervention_Pharmacological, IV MP bimonthly is a Intervention_Pharmacological, response to treatment is a Outcome_Other, 20 % improvement from basal conditions is a Outcome_Physical, clinical , laboratory , or specific neurological testing variables is a Outcome_Physical, response rate is a Outcome_Other, effective is a Outcome_Other
20946_task0
Sentence: Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical
[ "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE .
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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological" ]
cyclophosphamide is a Intervention_Pharmacological, methylprednisolone is a Intervention_Pharmacological, IV MP bimonthly is a Intervention_Pharmacological, response to treatment is a Outcome_Other, 20 % improvement from basal conditions is a Outcome_Physical, clinical , laboratory , or specific neurological testing variables is a Outcome_Physical, response rate is a Outcome_Other, effective is a Outcome_Other
20946_task1
Sentence: Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE . Instructions: please typing these entity words according to sentence: cyclophosphamide, methylprednisolone, IV MP bimonthly, response to treatment, 20 % improvement from basal conditions, clinical , laboratory , or specific neurological testing variables, response rate, effective Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical
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Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE .
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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological" ]
cyclophosphamide, methylprednisolone, IV MP bimonthly, response to treatment, 20 % improvement from basal conditions, clinical , laboratory , or specific neurological testing variables, response rate, effective
20946_task2
Sentence: Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE . Instructions: please extract entity words from the input sentence
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Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus . BACKGROUND Severe neurological involvement in systemic lupus erythematosus ( NPSLE ) is one of the most dreadful complications of the disease . OBJECTIVE To identify the best drug , dose , and treatment . PATIENTS AND METHODS The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria , with incident ( no more than 15 days ) onset of severe NP manifestations such as seizures , optic neuritis , peripheral or cranial neuropathy , coma , brainstem disease , or transverse myelitis . Induction treatment with 3 g of IV methylprednisolone ( MP ) followed by either IV monthly cyclophosphamide ( Cy ) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year . The primary end point was response to treatment : at least 20 % improvement from basal conditions on clinical , laboratory , or specific neurological testing variables . RESULTS Overall , a response rate of 75 % was observed . Of the 32 patients studied , 18/19 receiving Cy and 7/13 receiving MP responded to treatment ( p < 0.03 ) . CONCLUSIONS Cy seems to be more effective than MP in the treatment of acute , severe NPSLE .
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[ "Outcome_Physical", "Outcome_Other", "Intervention_Pharmacological" ]
tumor necrosis factor - alpha is a Protein, TNF is a Protein, vascular cell adhesion molecule 1 is a Protein, VCAM-1 is a Protein, interleukin-4 is a Protein, IL-4 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, TNF is a Protein, VCAM-1 is a Protein
611_task0
Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis).
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[ "Protein" ]
tumor necrosis factor - alpha is a Protein, TNF is a Protein, vascular cell adhesion molecule 1 is a Protein, VCAM-1 is a Protein, interleukin-4 is a Protein, IL-4 is a Protein, VCAM-1 is a Protein, E - selectin is a Protein, TNF is a Protein, VCAM-1 is a Protein
611_task1
Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis). Instructions: please typing these entity words according to sentence: tumor necrosis factor - alpha, TNF, vascular cell adhesion molecule 1, VCAM-1, interleukin-4, IL-4, VCAM-1, E - selectin, TNF, VCAM-1 Options: Protein
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Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis).
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[ "Protein" ]
tumor necrosis factor - alpha, TNF, vascular cell adhesion molecule 1, VCAM-1, interleukin-4, IL-4, VCAM-1, E - selectin, TNF, VCAM-1
611_task2
Sentence: Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis). Instructions: please extract entity words from the input sentence
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Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells. We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF. Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression. This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis).
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[ "Protein" ]
BRCA2 is a GENE-Y, RAD51 is a GENE-Y, RAD51 is a GENE-Y, RadA is a GENE-N, phenylalanine is a CHEMICAL, FxxA interaction motif is a GENE-N, BRCA2 is a GENE-Y
4195_task0
Sentence: Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL, GENE-Y, GENE-N
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Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site.
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[ "GENE-N", "CHEMICAL", "GENE-Y" ]
BRCA2 is a GENE-Y, RAD51 is a GENE-Y, RAD51 is a GENE-Y, RadA is a GENE-N, phenylalanine is a CHEMICAL, FxxA interaction motif is a GENE-N, BRCA2 is a GENE-Y
4195_task1
Sentence: Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site. Instructions: please typing these entity words according to sentence: BRCA2, RAD51, RAD51, RadA, phenylalanine, FxxA interaction motif, BRCA2 Options: CHEMICAL, GENE-Y, GENE-N
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Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site.
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[ "GENE-N", "CHEMICAL", "GENE-Y" ]
BRCA2, RAD51, RAD51, RadA, phenylalanine, FxxA interaction motif, BRCA2
4195_task2
Sentence: Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site. Instructions: please extract entity words from the input sentence
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Using a fragment-based approach to target protein-protein interactions. The ability to identify inhibitors of protein-protein interactions represents a major challenge in modern drug discovery and in the development of tools for chemical biology. In recent years, fragment-based approaches have emerged as a new methodology in drug discovery; however, few examples of small molecules that are active against chemotherapeutic targets have been published. Herein, we describe the fragment-based approach of targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51; it makes use of a screening pipeline of biophysical techniques that we expect to be more generally applicable to similar targets. Disruption of this interaction in vivo is hypothesised to give rise to cellular hypersensitivity to radiation and genotoxic drugs. We have used protein engineering to create a monomeric form of RAD51 by humanising a thermostable archaeal orthologue, RadA, and used this protein for fragment screening. The initial fragment hits were thoroughly validated biophysically by isothermal titration calorimetry (ITC) and NMR techniques and observed by X-ray crystallography to bind in a shallow surface pocket that is occupied in the native complex by the side chain of a phenylalanine from the conserved FxxA interaction motif found in BRCA2. This represents the first report of fragments or any small molecule binding at this protein-protein interaction site.
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[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Lactococcus lactis is a Microorganism, Lactococcus lactis subsp . lactis is a Microorganism, cheese is a Habitat, Lc . lactis subsp . cremoris is a Microorganism, Lc . lactis subsp . cremoris is a Microorganism, cheeses is a Habitat, LAB is a Phenotype, starter culture is a Habitat, NSLAB is a Phenotype, Lactobacillus paracasei is a Microorganism, cheeses is a Habitat, Lb . paracasei is a Microorganism, NSLAB is a Phenotype, Danbo cheeses is a Habitat
104_task0
Sentence: A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Microorganism, Phenotype, Habitat
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A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses.
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[ "Microorganism", "Habitat", "Phenotype" ]
Lactococcus lactis is a Microorganism, Lactococcus lactis subsp . lactis is a Microorganism, cheese is a Habitat, Lc . lactis subsp . cremoris is a Microorganism, Lc . lactis subsp . cremoris is a Microorganism, cheeses is a Habitat, LAB is a Phenotype, starter culture is a Habitat, NSLAB is a Phenotype, Lactobacillus paracasei is a Microorganism, cheeses is a Habitat, Lb . paracasei is a Microorganism, NSLAB is a Phenotype, Danbo cheeses is a Habitat
104_task1
Sentence: A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses. Instructions: please typing these entity words according to sentence: Lactococcus lactis, Lactococcus lactis subsp . lactis, cheese, Lc . lactis subsp . cremoris, Lc . lactis subsp . cremoris, cheeses, LAB, starter culture, NSLAB, Lactobacillus paracasei, cheeses, Lb . paracasei, NSLAB, Danbo cheeses Options: Microorganism, Phenotype, Habitat
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A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses.
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[ "Microorganism", "Habitat", "Phenotype" ]
Lactococcus lactis, Lactococcus lactis subsp . lactis, cheese, Lc . lactis subsp . cremoris, Lc . lactis subsp . cremoris, cheeses, LAB, starter culture, NSLAB, Lactobacillus paracasei, cheeses, Lb . paracasei, NSLAB, Danbo cheeses
104_task2
Sentence: A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses. Instructions: please extract entity words from the input sentence
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A difference in autolysis can be seen between the two subspecies of Lactococcus lactis. Lactococcus lactis subsp. lactis survives better in cheese than Lc. lactis subsp. cremoris [8]. This fact even though not examined in the present study suggests that the level of autolysis of the latter is the highest and thus explains why Lc. lactis subsp. cremoris was generally not found in the cheeses at the end of ripening, even though it was added as a part of the primary LAB starter culture. Contrary, the NSLAB Lactobacillus paracasei was found in three out of four cheeses. This confirms the findings by Antonsson et al. [1], who found Lb. paracasei to be the main NSLAB in several Danbo cheeses.
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[ "Microorganism", "Habitat", "Phenotype" ]
tierexperimentellen is an umlsterm, Technik is an umlsterm, Menschen is an umlsterm, Paris is an umlsterm, Funktionswiederherstellung is an umlsterm, Zeit is an umlsterm
HNO.00480801.ger.abstr_task0
Sentence: Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit .
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[ "umlsterm" ]
tierexperimentellen is an umlsterm, Technik is an umlsterm, Menschen is an umlsterm, Paris is an umlsterm, Funktionswiederherstellung is an umlsterm, Zeit is an umlsterm
HNO.00480801.ger.abstr_task1
Sentence: Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit . Instructions: please typing these entity words according to sentence: tierexperimentellen, Technik, Menschen, Paris, Funktionswiederherstellung, Zeit Options: umlsterm
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Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit .
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[ "umlsterm" ]
tierexperimentellen, Technik, Menschen, Paris, Funktionswiederherstellung, Zeit
HNO.00480801.ger.abstr_task2
Sentence: Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit . Instructions: please extract entity words from the input sentence
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Bereits Aristoteles Herophilos und Galen , gelangen in der Antike entscheidende anatomische Entdeckungen . Der Roemer Paul von Aegina fixierte die Idee einer Nervennaht als erster im 7. Jahrhundert , die aber erst im 17. Jahrhundert durch den Mailaender Chirurgen Gabriele Ferrara ihre praktische Umsetzung fand . Systematische Untersuchungen zu tierexperimentellen Nervennaehten datieren auf das fruehe 19. Jahrhundert durch Jean Pierre Flourens . 35 Jahre spaeter wurde die Technik beim Menschen eingesetzt . Zeitgleich fuehrten in Paris 2 Chirurgen ( Nélaton und Laugier ) eine Nervennaht durch . Wegen der Durchfuehrung selber , aber erst recht wegen der Behauptung , diese Nervennaehte haetten eine sofortige Funktionswiederherstellung zur Folge gehabt , entstand eine enorme Konfrontation unter den Chirurgen der damaligen Zeit .
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[ "umlsterm" ]
Aneurysma is an umlsterm, Arteriosklerose is an umlsterm, diagnoseweisend is an umlsterm, Rupturgefahr is an umlsterm, Therapie is an umlsterm, Ligatur is an umlsterm, prothesenbeschichteter is an umlsterm, Stents is an umlsterm, Aneurysma is an umlsterm
DerChirurg.00711285.ger.abstr_task0
Sentence: Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus .
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[ "umlsterm" ]
Aneurysma is an umlsterm, Arteriosklerose is an umlsterm, diagnoseweisend is an umlsterm, Rupturgefahr is an umlsterm, Therapie is an umlsterm, Ligatur is an umlsterm, prothesenbeschichteter is an umlsterm, Stents is an umlsterm, Aneurysma is an umlsterm
DerChirurg.00711285.ger.abstr_task1
Sentence: Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus . Instructions: please typing these entity words according to sentence: Aneurysma, Arteriosklerose, diagnoseweisend, Rupturgefahr, Therapie, Ligatur, prothesenbeschichteter, Stents, Aneurysma Options: umlsterm
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Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus .
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[ "umlsterm" ]
Aneurysma, Arteriosklerose, diagnoseweisend, Rupturgefahr, Therapie, Ligatur, prothesenbeschichteter, Stents, Aneurysma
DerChirurg.00711285.ger.abstr_task2
Sentence: Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Unter den ohnehin seltenen Aneurysmen der Visceralarterien ist das Aneurysma der A. pancreaticoduodenalis eine Raritaet . Aetiologisch kommen zahlreiche Faktoren in Betracht , es dominiert jedoch die Arteriosklerose . Das klinische Bild ist unspezifisch und vieldeutig . CT und vor allem intraarterielle DSA sind diagnoseweisend . Die grosszuegige Indikationsstellung zum operativen Eingriff - auch im asymptomatischen Stadium - wird insbesondere durch die immanente Rupturgefahr gerechtfertigt . Die Therapie der Wahl besteht in der Aneurysmaausschaltung : entweder konventionell durch proximale und distale Ligatur der A. pancreaticoduodenalis oder auf endovasculaerem Weg durch Embolisation . In Zukunft scheint auch eine Versorgung mittels prothesenbeschichteter Stents ( TPEG ) moeglich . Besonderes Augenmerk ist auf konkomitante Verschlussprozesse der anderen Visceralarterien zu richten , da durch die operative Beeintraechtigung der Collateralzirkulation gefaessrekonstruktive Massnahmen erforderlich werden koennen . Wir berichten ueber ein rupturiertes Aneurysma der A. pancreaticoduodenalis inferior in Kombination mit einem Verschluss des Truncus coeliacus .
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[ "umlsterm" ]
Tumoren is an umlsterm, Pleura is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, weibliches is an umlsterm, Geschlecht is an umlsterm, Radiotherapie is an umlsterm, Ergussbehandlung is an umlsterm, Thoraxwandinfiltration is an umlsterm, Chemotherapie is an umlsterm
DerChirurg.00710887.ger.abstr_task0
Sentence: Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden .
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[ "umlsterm" ]
Tumoren is an umlsterm, Pleura is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Prognose is an umlsterm, weibliches is an umlsterm, Geschlecht is an umlsterm, Radiotherapie is an umlsterm, Ergussbehandlung is an umlsterm, Thoraxwandinfiltration is an umlsterm, Chemotherapie is an umlsterm
DerChirurg.00710887.ger.abstr_task1
Sentence: Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden . Instructions: please typing these entity words according to sentence: Tumoren, Pleura, Patienten, Patienten, Therapie, Prognose, weibliches, Geschlecht, Radiotherapie, Ergussbehandlung, Thoraxwandinfiltration, Chemotherapie Options: umlsterm
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Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden .
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[ "umlsterm" ]
Tumoren, Pleura, Patienten, Patienten, Therapie, Prognose, weibliches, Geschlecht, Radiotherapie, Ergussbehandlung, Thoraxwandinfiltration, Chemotherapie
DerChirurg.00710887.ger.abstr_task2
Sentence: Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Primaere Tumoren der Pleura und des Peritoneums stellen eine besondere therapeutische Herausforderung dar . Waehrend die sehr seltenen lokalisierten Formen des Pleuramesothelioms eher zufaellig entdeckt und durch lokal radikale Operation geheilt werden koennen , praesentieren sich die meisten Patienten mit der diffusen , stets malignen Form im weit fortgeschrittenen Krankheitsstadium . Die meisten dieser Patienten ueberleben unabhaengig von der eingeschlagenen Therapie weniger als 12 Monate . Fuer das diffuse Pleuramesotheliom werden als Faktoren mit relativ guenstiger Prognose identifiziert : Fruehes Krankheitsstadium nach IMIG ( International Mesothelioma Interest Group ) , epithelialer Typ , Alter unter Fuenfzig , weibliches Geschlecht . Im Stadium I und II nach IMIG wird eine erweiterte Pleurapneumonektomie mit nachfolgender Chemo- und/oder Radiotherapie empfohlen . Fuer dieses Kollektiv kann eine mediane Ueberlebenszeit von 20-30 Monaten erreicht werden . Als palliative chirurgische Verfahren werden die Pleurektomie bzw. Decortikation zur Ergussbehandlung eingesetzt . Bei chirurgisch nicht angehbarer Thoraxwandinfiltration ist eine Bestrahlung indiziert , in Einzelfaellen kann auch durch Chemotherapie eine Teilremission und subjektive Besserung erzielt werden .
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[ "umlsterm" ]
glucocorticoid receptor is a Individual_protein, AP-1 is a Individual_protein
38_task0
Sentence: A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein
[ "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
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[ "Individual_protein" ]
glucocorticoid receptor is a Individual_protein, AP-1 is a Individual_protein
38_task1
Sentence: A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. Instructions: please typing these entity words according to sentence: glucocorticoid receptor, AP-1 Options: Individual_protein
[ "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
[ "A", "distinct", "modulating", "domain", "in", "glucocorticoid", "receptor", "monomers", "in", "the", "repression", "of", "activity", "of", "the", "transcription", "factor", "AP-1", "." ]
[ "Individual_protein" ]
glucocorticoid receptor, AP-1
38_task2
Sentence: A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-Individual_protein", "I-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O" ]
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
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[ "Individual_protein" ]
goal is an umlsterm, premedication is an umlsterm, prevention is an umlsterm, side effects is an umlsterm, anesthetics is an umlsterm, anticholinergics is an umlsterm, antiemetic is an umlsterm, antihistaminics is an umlsterm, opioids is an umlsterm, premedication is an umlsterm, administration is an umlsterm, anesthetics is an umlsterm, side effects is an umlsterm, aim is an umlsterm, premedication is an umlsterm, drugs is an umlsterm, patients is an umlsterm, administration is an umlsterm, anesthesia is an umlsterm, time is an umlsterm, drug is an umlsterm, premedication is an umlsterm, electroencephalogram is an umlsterm, EEG is an umlsterm, Patients is an umlsterm, methods is an umlsterm, adult is an umlsterm, patients is an umlsterm, ASA is an umlsterm, elective surgery is an umlsterm, EEG is an umlsterm, premedication is an umlsterm, patients is an umlsterm, midazolam is an umlsterm, nordazepam is an umlsterm, atropine is an umlsterm, promethazine is an umlsterm, atropine is an umlsterm, promethazine is an umlsterm, pethidine is an umlsterm, EEG is an umlsterm, period is an umlsterm, period is an umlsterm, premedication is an umlsterm, EEG is an umlsterm, electroencephalometry is an umlsterm, electrodes is an umlsterm, Date is an umlsterm, amplifier is an umlsterm, bit is an umlsterm, EEG is an umlsterm, analysis is an umlsterm, fast is an umlsterm, frequency is an umlsterm, EEG is an umlsterm, power is an umlsterm, colors is an umlsterm, map is an umlsterm, power is an umlsterm, distribution is an umlsterm, time is an umlsterm, period is an umlsterm, periods is an umlsterm, evaluation is an umlsterm, All is an umlsterm, period is an umlsterm, power is an umlsterm, frequency is an umlsterm, electrode is an umlsterm, period is an umlsterm, values is an umlsterm, power is an umlsterm, time is an umlsterm, period is an umlsterm, premedication is an umlsterm, period is an umlsterm, benzodiazepine is an umlsterm, power is an umlsterm, power is an umlsterm, period is an umlsterm, electrodes is an umlsterm, power is an umlsterm, nordazepam is an umlsterm
DerAnaesthesist.40430431.eng.abstr_task0
Sentence: Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase .
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[ "umlsterm" ]
goal is an umlsterm, premedication is an umlsterm, prevention is an umlsterm, side effects is an umlsterm, anesthetics is an umlsterm, anticholinergics is an umlsterm, antiemetic is an umlsterm, antihistaminics is an umlsterm, opioids is an umlsterm, premedication is an umlsterm, administration is an umlsterm, anesthetics is an umlsterm, side effects is an umlsterm, aim is an umlsterm, premedication is an umlsterm, drugs is an umlsterm, patients is an umlsterm, administration is an umlsterm, anesthesia is an umlsterm, time is an umlsterm, drug is an umlsterm, premedication is an umlsterm, electroencephalogram is an umlsterm, EEG is an umlsterm, Patients is an umlsterm, methods is an umlsterm, adult is an umlsterm, patients is an umlsterm, ASA is an umlsterm, elective surgery is an umlsterm, EEG is an umlsterm, premedication is an umlsterm, patients is an umlsterm, midazolam is an umlsterm, nordazepam is an umlsterm, atropine is an umlsterm, promethazine is an umlsterm, atropine is an umlsterm, promethazine is an umlsterm, pethidine is an umlsterm, EEG is an umlsterm, period is an umlsterm, period is an umlsterm, premedication is an umlsterm, EEG is an umlsterm, electroencephalometry is an umlsterm, electrodes is an umlsterm, Date is an umlsterm, amplifier is an umlsterm, bit is an umlsterm, EEG is an umlsterm, analysis is an umlsterm, fast is an umlsterm, frequency is an umlsterm, EEG is an umlsterm, power is an umlsterm, colors is an umlsterm, map is an umlsterm, power is an umlsterm, distribution is an umlsterm, time is an umlsterm, period is an umlsterm, periods is an umlsterm, evaluation is an umlsterm, All is an umlsterm, period is an umlsterm, power is an umlsterm, frequency is an umlsterm, electrode is an umlsterm, period is an umlsterm, values is an umlsterm, power is an umlsterm, time is an umlsterm, period is an umlsterm, premedication is an umlsterm, period is an umlsterm, benzodiazepine is an umlsterm, power is an umlsterm, power is an umlsterm, period is an umlsterm, electrodes is an umlsterm, power is an umlsterm, nordazepam is an umlsterm
DerAnaesthesist.40430431.eng.abstr_task1
Sentence: Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase . Instructions: please typing these entity words according to sentence: goal, premedication, prevention, side effects, anesthetics, anticholinergics, antiemetic, antihistaminics, opioids, premedication, administration, anesthetics, side effects, aim, premedication, drugs, patients, administration, anesthesia, time, drug, premedication, electroencephalogram, EEG, Patients, methods, adult, patients, ASA, elective surgery, EEG, premedication, patients, midazolam, nordazepam, atropine, promethazine, atropine, promethazine, pethidine, EEG, period, period, premedication, EEG, electroencephalometry, electrodes, Date, amplifier, bit, EEG, analysis, fast, frequency, EEG, power, colors, map, power, distribution, time, period, periods, evaluation, All, period, power, frequency, electrode, period, values, power, time, period, premedication, period, benzodiazepine, power, power, period, electrodes, power, nordazepam Options: umlsterm
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Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase .
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[ "umlsterm" ]
goal, premedication, prevention, side effects, anesthetics, anticholinergics, antiemetic, antihistaminics, opioids, premedication, administration, anesthetics, side effects, aim, premedication, drugs, patients, administration, anesthesia, time, drug, premedication, electroencephalogram, EEG, Patients, methods, adult, patients, ASA, elective surgery, EEG, premedication, patients, midazolam, nordazepam, atropine, promethazine, atropine, promethazine, pethidine, EEG, period, period, premedication, EEG, electroencephalometry, electrodes, Date, amplifier, bit, EEG, analysis, fast, frequency, EEG, power, colors, map, power, distribution, time, period, periods, evaluation, All, period, power, frequency, electrode, period, values, power, time, period, premedication, period, benzodiazepine, power, power, period, electrodes, power, nordazepam
DerAnaesthesist.40430431.eng.abstr_task2
Sentence: Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase . Instructions: please extract entity words from the input sentence
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Introduction . For many years , the main goal of premedication was prevention of the dangerous side effects sometimes encountered in anesthetics with anticholinergics , antiemetic antihistaminics , and opioids . Because the rules were always preoperative fasting , premedication was administered i.m. Thus , the onset of action was within 15 - 30 min from administration . In recent years , with the introduction of newer anesthetics with fewer side effects , anxiolysis became the main aim in premedication . Moreover , the oral route became popular since it obviously did not increase the acidity or volume of the gastric content . However , the uptake and thus onset of action of orally administered drugs may take longer and can differ considerably between individual patients . Therefore , the optimum interval between administration and induction of anesthesia remains controversial . The present study was carried out to examine the time course of drug action and the effects of different premedication regimens on the electroencephalogram ( EEG ) . Patients and methods . After obtaining informed consent , in 38 unselected adult patients ( ASA I and II , 65 years ) scheduled for elective surgery , the EEG was recorded continuously before and after premedication . The patients were randomly assigned to four groups : M : midazolam , 0.2 mg/kg BW orally ; N : nordazepam , 0.2 mg/kg BW orally ; AP : atropine , 0.5 mg , plus promethazine , 50 mg i.m. ; APP : atropine , 0.5 mg , plus promethazine , 50 mg , plus pethidine , 0.7 mg/kg BW i.m. The EEG was recorded for a reference period of 10 min before and a study period of 30 min after premedication . Automated EEG processing was performed with CATEEM ( computer-aided topographical electroencephalometry ) . Surface electrodes were placed according to the 10 - 20 system . Date were collected via an amplifier ( resistance 10 M ) and a digitalization unit ( filter 0.2 - 35 Hz , sampling rate 512 Hz , 12 bit A/D convertor ) . The original EEG signals were used in an interpolation algorythm to produce an additional 82 virtual recording points , allowing for high topographical resolution . After spectral analysis ( fast Fourier transformation ) , the different frequency ranges of the EEG power spectrum are displayed in different colors . The screen displays the on-line map with color-based topographical power distribution . In order to achieve a pharmacodynamic time profile , the study period was subdivided into three periods of 10 min each . For clinical evaluation of vigilance , a 6-grade scoring system was used ( 1=awake, 6=not arousable ) . Results . All data are presented with respect to reference period . The power density of each frequency range for each electrode is integrated over the selected period and mean values are shown . Changes in power density with time are expressed as percentage change from reference period . Biometrical data showed no significant differences between groups . The median vigilance score 30 min after premedication ( end of study period ) was 4 in groups M , AP , and APP , and 3 in group N. In both benzodiazepine groups , a distinct increase in power density was found in the -bands , while in groups AP and APP the increase was most pronounced in the and bands . In group M , there was a linear increase in 1 power up to 310% , while in the 2 range there was a 170% maximum within the second period of 10 min . In group N , there was a similar course with a lower increase in 1 ( 220% ) and 2 ( 130% ) . Increases in both -bands were most pronounced with frontal electrodes . While group M showed an increase in power ( 150% ) , together with moderate suppression in ( 1 50% , 2 40% ) , nordazepam caused only a slight increase .
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"midazolam", ",", "0.2", "mg", "/", "kg", "BW", "orally", ";", "N", ":", "nordazepam", ",", "0.2", "mg", "/", "kg", "BW", "orally", ";", "AP", ":", "atropine", ",", "0.5", "mg", ",", "plus", "promethazine", ",", "50", "mg", "i.m", ".", ";", "APP", ":", "atropine", ",", "0.5", "mg", ",", "plus", "promethazine", ",", "50", "mg", ",", "plus", "pethidine", ",", "0.7", "mg", "/", "kg", "BW", "i.m", ".", "The", "EEG", "was", "recorded", "for", "a", "reference", "period", "of", "10", "min", "before", "and", "a", "study", "period", "of", "30", "min", "after", "premedication", ".", "Automated", "EEG", "processing", "was", "performed", "with", "CATEEM", "(", "computer", "-", "aided", "topographical", "electroencephalometry", ")", ".", "Surface", "electrodes", "were", "placed", "according", "to", "the", "10", "-", "20", "system", ".", "Date", "were", "collected", "via", "an", "amplifier", "(", "resistance", "10", "M", ")", "and", "a", "digitalization", "unit", "(", "filter", "0.2", "-", "35", "Hz", ",", "sampling", "rate", "512", "Hz", ",", "12", "bit", "A", "/", "D", "convertor", ")", ".", "The", "original", "EEG", "signals", "were", "used", "in", "an", "interpolation", "algorythm", "to", "produce", "an", "additional", "82", "virtual", "recording", "points", ",", "allowing", "for", "high", "topographical", "resolution", ".", "After", "spectral", "analysis", "(", "fast", "Fourier", "transformation", ")", ",", "the", "different", "frequency", "ranges", "of", "the", "EEG", "power", "spectrum", "are", "displayed", "in", "different", "colors", ".", "The", "screen", "displays", "the", "on", "-", "line", "map", "with", "color", "-", "based", "topographical", "power", "distribution", ".", "In", "order", "to", "achieve", "a", "pharmacodynamic", "time", "profile", ",", "the", "study", "period", "was", "subdivided", "into", "three", "periods", "of", "10", "min", "each", ".", "For", "clinical", "evaluation", "of", "vigilance", ",", "a", "6-grade", "scoring", "system", "was", "used", 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[ "umlsterm" ]
Glucocorticoid receptor is a protein_family_or_group, patients is a multi_cell, lupus nephritis is an other_name, receptor levels is an other_name, mononuclear leukocytes is a cell_type, glucocorticoid therapy is an other_name
85199_task0
Sentence: Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, multi_cell, other_name
[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "B-other_name", "I-other_name", "O" ]
Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
[ "Glucocorticoid", "receptor", "in", "patients", "with", "lupus", "nephritis", ":", "relationship", "between", "receptor", "levels", "in", "mononuclear", "leukocytes", "and", "effect", "of", "glucocorticoid", "therapy", "." ]
[ "other_name", "protein_family_or_group", "cell_type", "multi_cell" ]
Glucocorticoid receptor is a protein_family_or_group, patients is a multi_cell, lupus nephritis is an other_name, receptor levels is an other_name, mononuclear leukocytes is a cell_type, glucocorticoid therapy is an other_name
85199_task1
Sentence: Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy. Instructions: please typing these entity words according to sentence: Glucocorticoid receptor, patients, lupus nephritis, receptor levels, mononuclear leukocytes, glucocorticoid therapy Options: cell_type, protein_family_or_group, multi_cell, other_name
[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "B-other_name", "I-other_name", "O" ]
Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
[ "Glucocorticoid", "receptor", "in", "patients", "with", "lupus", "nephritis", ":", "relationship", "between", "receptor", "levels", "in", "mononuclear", "leukocytes", "and", "effect", "of", "glucocorticoid", "therapy", "." ]
[ "other_name", "protein_family_or_group", "cell_type", "multi_cell" ]
Glucocorticoid receptor, patients, lupus nephritis, receptor levels, mononuclear leukocytes, glucocorticoid therapy
85199_task2
Sentence: Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy. Instructions: please extract entity words from the input sentence
[ "B-protein_family_or_group", "I-protein_family_or_group", "O", "B-multi_cell", "O", "B-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "O", "B-other_name", "I-other_name", "O" ]
Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
[ "Glucocorticoid", "receptor", "in", "patients", "with", "lupus", "nephritis", ":", "relationship", "between", "receptor", "levels", "in", "mononuclear", "leukocytes", "and", "effect", "of", "glucocorticoid", "therapy", "." ]
[ "other_name", "protein_family_or_group", "cell_type", "multi_cell" ]
gelatin is a Gene/protein/RNA, laminin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, laminin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, beta1 integrin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, paxillin is a Gene/protein/RNA, actin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, talin is a Gene/protein/RNA
809_task0
Sentence: The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O" ]
The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions.
[ "The", "undifferentiated", "cells", "(", "a", ")", "were", "unable", "to", "spread", "on", "gelatin", "or", "laminin", "and", "grew", "as", "rounded", "colonies", ",", "although", "they", "were", "able", "to", "spread", "on", "fibronectin", "(", "b", ")", "showed", "reduced", "adhesion", "to", "laminin", ",", "but", "not", "fibronectin", "(", "c", ")", "expressed", "much", "reduced", "levels", "of", "beta1", "integrin", ",", "although", "levels", "of", "alpha5", "and", "alphaV", "were", "wild", "-", "type", "(", "d", ")", "were", "less", "polarized", "with", "increased", "membrane", "protrusions", "compared", "with", "a", "vinculin", "(", "-/-", ")", "ES", "cell", "mutant", "(", "e", ")", "were", "unable", "to", "assemble", "vinculin", "or", "paxillin", "-", "containing", "focal", "adhesions", "or", "actin", "stress", "fibers", "on", "fibronectin", ",", "whereas", "vinculin", "(", "-/-", ")", "ES", "cells", "were", "able", "to", "assemble", "talin", "-", "containing", "focal", "adhesions", "." ]
[ "Gene/protein/RNA" ]
gelatin is a Gene/protein/RNA, laminin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, laminin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, beta1 integrin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, paxillin is a Gene/protein/RNA, actin is a Gene/protein/RNA, fibronectin is a Gene/protein/RNA, vinculin is a Gene/protein/RNA, talin is a Gene/protein/RNA
809_task1
Sentence: The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions. Instructions: please typing these entity words according to sentence: gelatin, laminin, fibronectin, laminin, fibronectin, beta1 integrin, vinculin, vinculin, paxillin, actin, fibronectin, vinculin, talin Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O" ]
The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions.
[ "The", "undifferentiated", "cells", "(", "a", ")", "were", "unable", "to", "spread", "on", "gelatin", "or", "laminin", "and", "grew", "as", "rounded", "colonies", ",", "although", "they", "were", "able", "to", "spread", "on", "fibronectin", "(", "b", ")", "showed", "reduced", "adhesion", "to", "laminin", ",", "but", "not", "fibronectin", "(", "c", ")", "expressed", "much", "reduced", "levels", "of", "beta1", "integrin", ",", "although", "levels", "of", "alpha5", "and", "alphaV", "were", "wild", "-", "type", "(", "d", ")", "were", "less", "polarized", "with", "increased", "membrane", "protrusions", "compared", "with", "a", "vinculin", "(", "-/-", ")", "ES", "cell", "mutant", "(", "e", ")", "were", "unable", "to", "assemble", "vinculin", "or", "paxillin", "-", "containing", "focal", "adhesions", "or", "actin", "stress", "fibers", "on", "fibronectin", ",", "whereas", "vinculin", "(", "-/-", ")", "ES", "cells", "were", "able", "to", "assemble", "talin", "-", "containing", "focal", "adhesions", "." ]
[ "Gene/protein/RNA" ]
gelatin, laminin, fibronectin, laminin, fibronectin, beta1 integrin, vinculin, vinculin, paxillin, actin, fibronectin, vinculin, talin
809_task2
Sentence: The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O" ]
The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions.
[ "The", "undifferentiated", "cells", "(", "a", ")", "were", "unable", "to", "spread", "on", "gelatin", "or", "laminin", "and", "grew", "as", "rounded", "colonies", ",", "although", "they", "were", "able", "to", "spread", "on", "fibronectin", "(", "b", ")", "showed", "reduced", "adhesion", "to", "laminin", ",", "but", "not", "fibronectin", "(", "c", ")", "expressed", "much", "reduced", "levels", "of", "beta1", "integrin", ",", "although", "levels", "of", "alpha5", "and", "alphaV", "were", "wild", "-", "type", "(", "d", ")", "were", "less", "polarized", "with", "increased", "membrane", "protrusions", "compared", "with", "a", "vinculin", "(", "-/-", ")", "ES", "cell", "mutant", "(", "e", ")", "were", "unable", "to", "assemble", "vinculin", "or", "paxillin", "-", "containing", "focal", "adhesions", "or", "actin", "stress", "fibers", "on", "fibronectin", ",", "whereas", "vinculin", "(", "-/-", ")", "ES", "cells", "were", "able", "to", "assemble", "talin", "-", "containing", "focal", "adhesions", "." ]
[ "Gene/protein/RNA" ]
old is an umlsterm, woman is an umlsterm, cardiac tamponade is an umlsterm, pus is an umlsterm, bacterial infection is an umlsterm, streptococcus is an umlsterm, resuscitation is an umlsterm, patient is an umlsterm, weakness is an umlsterm, temperature is an umlsterm, neck is an umlsterm, pain is an umlsterm, computed tomography is an umlsterm, infection is an umlsterm, right is an umlsterm, tonsil is an umlsterm, mediastinum is an umlsterm, pericardium is an umlsterm, surgery is an umlsterm, retropharyngeal abscess is an umlsterm, patient is an umlsterm, cardiac tamponade is an umlsterm, causes is an umlsterm, infections is an umlsterm, patient is an umlsterm, history is an umlsterm
ZfuerKardiologie.00890464.eng.abstr_task0
Sentence: We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O" ]
We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason .
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[ "umlsterm" ]
old is an umlsterm, woman is an umlsterm, cardiac tamponade is an umlsterm, pus is an umlsterm, bacterial infection is an umlsterm, streptococcus is an umlsterm, resuscitation is an umlsterm, patient is an umlsterm, weakness is an umlsterm, temperature is an umlsterm, neck is an umlsterm, pain is an umlsterm, computed tomography is an umlsterm, infection is an umlsterm, right is an umlsterm, tonsil is an umlsterm, mediastinum is an umlsterm, pericardium is an umlsterm, surgery is an umlsterm, retropharyngeal abscess is an umlsterm, patient is an umlsterm, cardiac tamponade is an umlsterm, causes is an umlsterm, infections is an umlsterm, patient is an umlsterm, history is an umlsterm
ZfuerKardiologie.00890464.eng.abstr_task1
Sentence: We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason . Instructions: please typing these entity words according to sentence: old, woman, cardiac tamponade, pus, bacterial infection, streptococcus, resuscitation, patient, weakness, temperature, neck, pain, computed tomography, infection, right, tonsil, mediastinum, pericardium, surgery, retropharyngeal abscess, patient, cardiac tamponade, causes, infections, patient, history Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O" ]
We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason .
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[ "umlsterm" ]
old, woman, cardiac tamponade, pus, bacterial infection, streptococcus, resuscitation, patient, weakness, temperature, neck, pain, computed tomography, infection, right, tonsil, mediastinum, pericardium, surgery, retropharyngeal abscess, patient, cardiac tamponade, causes, infections, patient, history
ZfuerKardiologie.00890464.eng.abstr_task2
Sentence: We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason . Instructions: please extract entity words from the input sentence
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We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade . Examination of the pus fluid showed a bacterial infection with streptococcus milleri . Four days before resuscitation the patient experienced weakness , dyspnoe , increased temperature ( 39 ° C ) , swelling of the neck , and pain on swallowing . Using computed tomography , examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium . After surgery to remove the retropharyngeal abscess , the patient healed well . Therefore , on presentation of a cardiac tamponade , possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered . In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason .
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[ "umlsterm" ]
Patienten is an umlsterm, Adenokarzinom is an umlsterm, Prostata is an umlsterm, Technik is an umlsterm, Technik is an umlsterm, Prostatahinterflaeche is an umlsterm, Samenblasen is an umlsterm, Venenkomplexes is an umlsterm
DerUrologeA.00390455.ger.abstr_task0
Sentence: 125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert .
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[ "umlsterm" ]
Patienten is an umlsterm, Adenokarzinom is an umlsterm, Prostata is an umlsterm, Technik is an umlsterm, Technik is an umlsterm, Prostatahinterflaeche is an umlsterm, Samenblasen is an umlsterm, Venenkomplexes is an umlsterm
DerUrologeA.00390455.ger.abstr_task1
Sentence: 125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert . Instructions: please typing these entity words according to sentence: Patienten, Adenokarzinom, Prostata, Technik, Technik, Prostatahinterflaeche, Samenblasen, Venenkomplexes Options: umlsterm
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125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert .
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[ "umlsterm" ]
Patienten, Adenokarzinom, Prostata, Technik, Technik, Prostatahinterflaeche, Samenblasen, Venenkomplexes
DerUrologeA.00390455.ger.abstr_task2
Sentence: 125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert . Instructions: please extract entity words from the input sentence
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125 konsekutive Patienten mit Adenokarzinom der Prostata wurden einer erweiterten radikalen perinealen Prostatektomie entsprechend der Technik von Weldon unterzogen . Diese Technik wurde durch die primaere komplette Mobilisation der Prostatahinterflaeche und der Samenblasen , der Inzision der Faszia endopelvina , der queren Inzision der Denonvillier-Faszia am Apex und der partiellen Durchtrennung des dorsalen Venenkomplexes nach vorangegangener Durchstechungsligatur modifiziert .
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[ "umlsterm" ]