broad_id
string | depmap_id
string | ccle_name
string | screen_id
string | upper_limit
int64 | lower_limit
float64 | slope
float64 | r2
float64 | auc
float64 | ec50
float64 | ic50
float64 | name
string | moa
string | target
string | disease.area
string | indication
string | smiles
string | phase
string | passed_str_profiling
bool | row_name
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRD-K33127281-001-05-6
|
ACH-000237
|
JHOM1_OVARY
|
HTS002
| 1 | 1.621055 | -4.823208 | 0.327379 | 1.297425 | 0.063661 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000237
|
BRD-K33127281-001-05-6
|
ACH-000811
|
SKOV3_OVARY
|
HTS002
| 1 | 1.241035 | -1.426796 | 0.208541 | 1.155317 | 0.318731 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000811
|
BRD-K33127281-001-05-6
|
ACH-000312
|
SKNBE2_AUTONOMIC_GANGLIA
|
HTS002
| 1 | 1.637153 | -0.339886 | 0.149789 | 1.226448 | 0.00938 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000312
|
BRD-K33127281-001-05-6
|
ACH-000390
|
LUDLU1_LUNG
|
HTS002
| 1 | 0.159785 | 3.101555 | 0.14416 | 0.872123 | 2.290992 | 2.593805 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000390
|
BRD-K33127281-001-05-6
|
ACH-000901
|
HCC1359_LUNG
|
HTS002
| 1 | 1.869168 | -0.428128 | 0.251001 | 1.319581 | 0.014557 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000901
|
BRD-K33127281-001-05-6
|
ACH-000307
|
PK1_PANCREAS
|
HTS002
| 1 | 0.53602 | 7.713765 | 0.247036 | 0.771272 | 0.08364 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000307
|
BRD-K33127281-001-05-6
|
ACH-000289
|
SNU466_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 1.301688 | -2.268475 | -0.017131 | 1.211162 | 0.544073 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000289
|
BRD-K33127281-001-05-6
|
ACH-000309
|
SKLU1_LUNG
|
HTS002
| 1 | 0.127114 | 1.385571 | 0.355689 | 0.785749 | 0.949129 | 1.17292 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000309
|
BRD-K33127281-001-05-6
|
ACH-000733
|
NCIH1838_LUNG
|
HTS002
| 1 | 1.595386 | -0.427192 | 0.009096 | 1.156781 | 0.003378 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000733
|
BRD-K33127281-001-05-6
|
ACH-000268
|
SNU245_BILIARY_TRACT
|
HTS002
| 1 | 1.555227 | -0.186121 | -0.048129 | 1.097922 | 0.000012 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000268
|
BRD-K33127281-001-05-6
|
ACH-000758
|
MKN74_STOMACH
|
HTS002
| 1 | 1.271551 | 0.047846 | -0.019287 | 1.126964 | 1.196297 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000758
|
BRD-K33127281-001-05-6
|
ACH-000693
|
KYSE180_OESOPHAGUS
|
HTS002
| 1 | 0.467658 | 2.948105 | 0.438815 | 0.933503 | 3.004336 | 7.60547 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000693
|
BRD-K33127281-001-05-6
|
ACH-000684
|
KMRC1_KIDNEY
|
HTS002
| 1 | 2.386085 | -0.241843 | 0.093926 | 1.70941 | 0.097083 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000684
|
BRD-K33127281-001-05-6
|
ACH-000264
|
CALU6_LUNG
|
HTS002
| 1 | 1.455538 | -1.761268 | 0.282888 | 1.30273 | 0.386444 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000264
|
BRD-K33127281-001-05-6
|
ACH-000027
|
GOS3_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 1.12963 | -0.146302 | -0.065468 | 1.097875 | 229.157698 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000027
|
BRD-K33127281-001-05-6
|
ACH-000205
|
PK59_PANCREAS
|
HTS002
| 1 | 1.601227 | -6.126228 | 0.27166 | 1.155534 | 0.007513 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000205
|
BRD-K33127281-001-05-6
|
ACH-000720
|
TCCSUP_URINARY_TRACT
|
HTS002
| 1 | 0.628007 | 6.976212 | -0.183202 | 0.921413 | 1.287235 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000720
|
BRD-K33127281-001-05-6
|
ACH-000814
|
HS939T_SKIN
|
HTS002
| 1 | 0.579579 | 0.651626 | 0.068265 | 0.792096 | 0.082785 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000814
|
BRD-K33127281-001-05-6
|
ACH-000885
|
TOV21G_OVARY
|
HTS002
| 1 | 0.310724 | 3.913024 | 0.222308 | 0.942252 | 4.483531 | 5.74689 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000885
|
BRD-K33127281-001-05-6
|
ACH-000663
|
OVTOKO_OVARY
|
HTS002
| 1 | 1.484844 | -2.633867 | 0.320595 | 1.256411 | 0.103368 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000663
|
BRD-K33127281-001-05-6
|
ACH-000647
|
TE1_OESOPHAGUS
|
HTS002
| 1 | 1.37656 | -1.490221 | 0.160828 | 1.145922 | 0.026163 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000647
|
BRD-K33127281-001-05-6
|
ACH-000243
|
DANG_PANCREAS
|
HTS002
| 1 | 1.456389 | -0.577176 | 0.142429 | 1.138084 | 0.008381 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000243
|
BRD-K33127281-001-05-6
|
ACH-000255
|
LMSU_STOMACH
|
HTS002
| 1 | 2.125783 | -1.129865 | 0.301258 | 1.213681 | 0.003422 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000255
|
BRD-K33127281-001-05-6
|
ACH-000335
|
MSTO211H_PLEURA
|
HTS002
| 1 | 0.169903 | 5.510059 | 0.648962 | 0.770258 | 0.681695 | 0.735051 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000335
|
BRD-K33127281-001-05-6
|
ACH-000147
|
T47D_BREAST
|
HTS002
| 1 | 0.674941 | 9.517525 | -0.009722 | 0.869902 | 0.205715 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000147
|
BRD-K33127281-001-05-6
|
ACH-000090
|
PC3_PROSTATE
|
HTS002
| 1 | 0.385521 | 2.905923 | 0.114533 | 0.93095 | 3.410664 | 5.664509 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000090
|
BRD-K33127281-001-05-6
|
ACH-000171
|
VMRCRCZ_KIDNEY
|
HTS002
| 1 | 1.64234 | -0.381301 | -0.079324 | 1.170392 | 0.002795 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000171
|
BRD-K33127281-001-05-6
|
ACH-000614
|
RVH421_SKIN
|
HTS002
| 1 | 1.41305 | -5.767857 | 0.182297 | 1.210989 | 0.086762 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000614
|
BRD-K33127281-001-05-6
|
ACH-000132
|
JHOS2_OVARY
|
HTS002
| 1 | 1.681929 | -0.106178 | 0.056091 | 1.286218 | 0.003459 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000132
|
BRD-K33127281-001-05-6
| null | null |
HTS002
| 1 | 1.972987 | -0.246885 | 0.269407 | 1.387691 | 0.012156 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| false |
ACH-000807_FAILED_STR
|
BRD-K33127281-001-05-6
|
ACH-000810
|
SKMEL30_SKIN
|
HTS002
| 1 | 2.29655 | -0.229941 | 0.264692 | 1.577569 | 0.02737 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000810
|
BRD-K33127281-001-05-6
|
ACH-000343
|
NCIH522_LUNG
|
HTS002
| 1 | 1.945447 | -0.190773 | 0.049851 | 1.438668 | 0.034763 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000343
|
BRD-K33127281-001-05-6
|
ACH-000022
|
PATU8988S_PANCREAS
|
HTS002
| 1 | 1.579176 | -0.812238 | -0.039537 | 1.140577 | 0.005302 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000022
|
BRD-K33127281-001-05-6
|
ACH-000192
|
MFE280_ENDOMETRIUM
|
HTS002
| 1 | 1.559717 | -0.362365 | 0.102105 | 1.218187 | 0.016846 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000192
|
BRD-K33127281-001-05-6
| null | null |
HTS002
| 1 | 1.721618 | -0.079774 | -0.110518 | 1.376038 | 0.228208 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| false |
ACH-000409_FAILED_STR
|
BRD-K33127281-001-05-6
|
ACH-000959
|
SNUC4_LARGE_INTESTINE
|
HTS002
| 1 | 1.573033 | -4.940389 | 0.461194 | 1.383285 | 0.402239 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000959
|
BRD-K33127281-001-05-6
| null | null |
HTS002
| 1 | 0.993498 | 1.452291 | -0.400576 | 0.997721 | 0.334996 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| false |
ACH-000028_FAILED_STR
|
BRD-K33127281-001-05-6
|
ACH-000637
|
KYSE520_OESOPHAGUS
|
HTS002
| 1 | 1.449497 | -2.78157 | 0.333571 | 1.323382 | 0.657121 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000637
|
BRD-K33127281-001-05-6
|
ACH-000968
|
COLO792_SKIN
|
HTS002
| 1 | 1.697963 | -1.389872 | 0.062196 | 1.231722 | 0.015178 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000968
|
BRD-K33127281-001-05-6
|
ACH-000155
|
SW1990_PANCREAS
|
HTS002
| 1 | 0.461471 | 7.359047 | 0.244028 | 0.935698 | 3.139021 | 4.44694 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000155
|
BRD-K33127281-001-05-6
|
ACH-000133
|
HS729_SOFT_TISSUE
|
HTS002
| 1 | 3.509135 | -0.845275 | 0.104943 | 1.206389 | 0.000584 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000133
|
BRD-K33127281-001-05-6
|
ACH-000605
|
TE6_OESOPHAGUS
|
HTS002
| 1 | 0.313592 | 7.798358 | 0.244528 | 0.919692 | 3.21316 | 3.646535 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000605
|
BRD-K33127281-001-05-6
|
ACH-000775
|
NCIH727_LUNG
|
HTS002
| 1 | 1.725652 | -0.025446 | -0.01112 | 1.376229 | 1.432033 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000775
|
BRD-K33127281-001-05-6
|
ACH-000042
|
PANC0203_PANCREAS
|
HTS002
| 1 | 0.504014 | 3.438756 | 0.085797 | 0.956949 | 4.378933 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000042
|
BRD-K33127281-001-05-6
|
ACH-000860
|
NCIH358_LUNG
|
HTS002
| 1 | 1.618398 | -2.84785 | 0.42441 | 1.325051 | 0.100188 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000860
|
BRD-K33127281-001-05-6
|
ACH-000994
|
HEC59_ENDOMETRIUM
|
HTS002
| 1 | 1.954117 | -0.355354 | 0.234257 | 1.168663 | 0.000442 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000994
|
BRD-K33127281-001-05-6
|
ACH-000277
|
HCC1419_BREAST
|
HTS002
| 1 | 0.594335 | 4.849053 | -0.042458 | 0.864572 | 0.391781 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000277
|
BRD-K33127281-001-05-6
|
ACH-000496
|
NCIH1792_LUNG
|
HTS002
| 1 | 1.647592 | -0.006523 | -0.035911 | 1.320627 | 0.003885 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000496
|
BRD-K33127281-001-05-6
|
ACH-000866
|
NCIH1048_LUNG
|
HTS002
| 1 | 0.238588 | 0.96998 | 0.40741 | 0.786001 | 0.704625 | 1.37505 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000866
|
BRD-K33127281-001-05-6
|
ACH-000869
|
NCIH1568_LUNG
|
HTS002
| 1 | 1.426781 | -1.799675 | 0.339964 | 1.32043 | 0.897269 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000869
|
BRD-K33127281-001-05-6
|
ACH-000678
|
MKN7_STOMACH
|
HTS002
| 1 | 1.619249 | -0.579039 | 0.059752 | 1.128182 | 0.00243 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000678
|
BRD-K33127281-001-05-6
|
ACH-000493
|
SNU423_LIVER
|
HTS002
| 1 | 1.681152 | -0.359355 | 0.194116 | 1.185627 | 0.002773 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000493
|
BRD-K33127281-001-05-6
|
ACH-000468
|
PK45H_PANCREAS
|
HTS002
| 1 | 1.684394 | -0.112957 | -0.100421 | 1.402005 | 1.923708 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000468
|
BRD-K33127281-001-05-6
|
ACH-000097
|
ZR751_BREAST
|
HTS002
| 1 | 1.334114 | -3.89621 | 0.224511 | 1.111394 | 0.015512 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000097
|
BRD-K33127281-001-05-6
|
ACH-000313
|
KMRC3_KIDNEY
|
HTS002
| 1 | 0.525513 | 5.475842 | 0.183748 | 0.947739 | 3.435939 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000313
|
BRD-K33127281-001-05-6
|
ACH-000169
|
RD_SOFT_TISSUE
|
HTS002
| 1 | 2.111462 | -0.076102 | -0.066759 | 1.509967 | 0.008712 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000169
|
BRD-K33127281-001-05-6
| null | null |
HTS002
| 1 | 1.589994 | -2.09026 | 0.386427 | 1.234567 | 0.028911 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| false |
ACH-000010_FAILED_STR
|
BRD-K33127281-001-05-6
|
ACH-000895
|
CL34_LARGE_INTESTINE
|
HTS002
| 1 | 2.502359 | -0.209268 | 0.091192 | 1.398237 | 0.00041 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000895
|
BRD-K33127281-001-05-6
|
ACH-000841
|
NCIH2087_LUNG
|
HTS002
| 1 | 0.002125 | 0.830893 | 0.257653 | 0.777896 | 1.432081 | 1.43944 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000841
|
BRD-K33127281-001-05-6
|
ACH-000414
|
NCIH1944_LUNG
|
HTS002
| 1 | 1.316445 | -0.599954 | 0.099164 | 1.136061 | 0.036521 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000414
|
BRD-K33127281-001-05-6
|
ACH-000026
|
253JBV_URINARY_TRACT
|
HTS002
| 1 | 1.743268 | -0.266101 | 0.196126 | 1.314833 | 0.021015 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000026
|
BRD-K33127281-001-05-6
|
ACH-000966
|
IGROV1_OVARY
|
HTS002
| 1 | 0.994092 | 0.597772 | -0.221327 | 0.996283 | 0.018942 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000966
|
BRD-K33127281-001-05-6
|
ACH-000950
|
LOVO_LARGE_INTESTINE
|
HTS002
| 1 | 1.80776 | -0.823227 | 0.233395 | 1.226323 | 0.008102 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000950
|
BRD-K33127281-001-05-6
|
ACH-000750
|
LOXIMVI_SKIN
|
HTS002
| 1 | 1.73776 | -1.655619 | 0.408467 | 1.43449 | 0.185318 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000750
|
BRD-K33127281-001-05-6
|
ACH-000270
|
HPAC_PANCREAS
|
HTS002
| 1 | 0.273956 | 8.891263 | -0.286239 | 0.944103 | 4.738065 | 5.180576 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000270
|
BRD-K33127281-001-05-6
|
ACH-000480
|
HUH7_LIVER
|
HTS002
| 1 | 0.841939 | 0.949097 | -0.215644 | 0.918829 | 0.068319 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000480
|
BRD-K33127281-001-05-6
|
ACH-000897
|
FTC238_THYROID
|
HTS002
| 1 | 1.597519 | -0.182277 | 0.054705 | 1.208061 | 0.002023 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000897
|
BRD-K33127281-001-05-6
|
ACH-000389
|
H4_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 1.665624 | -3.203451 | 0.32638 | 1.374404 | 0.143261 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000389
|
BRD-K33127281-001-05-6
|
ACH-000862
|
KMBC2_URINARY_TRACT
|
HTS002
| 1 | 0.328613 | 4.288842 | 0.540909 | 0.90842 | 2.663686 | 3.419025 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000862
|
BRD-K33127281-001-05-6
|
ACH-000776
|
ONS76_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 0.803575 | 3.970555 | 0.023218 | 0.950327 | 0.859484 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000776
|
BRD-K33127281-001-05-6
|
ACH-000023
|
PATU8988T_PANCREAS
|
HTS002
| 1 | 1.263212 | -0.394218 | 0.081914 | 1.079923 | 0.005386 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000023
|
BRD-K33127281-001-05-6
|
ACH-000011
|
253J_URINARY_TRACT
|
HTS002
| 1 | 1.427889 | -0.389486 | 0.081511 | 1.118451 | 0.003505 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000011
|
BRD-K33127281-001-05-6
|
ACH-000973
|
639V_URINARY_TRACT
|
HTS002
| 1 | 0.086683 | 1.461466 | 0.514865 | 0.800275 | 1.236111 | 1.408105 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000973
|
BRD-K33127281-001-05-6
|
ACH-000971
|
HCT116_LARGE_INTESTINE
|
HTS002
| 1 | 0.628923 | 1.165134 | 0.250514 | 0.907532 | 0.939082 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000971
|
BRD-K33127281-001-05-6
|
ACH-000486
|
KU1919_URINARY_TRACT
|
HTS002
| 1 | 0.183143 | 4.242763 | 0.354232 | 0.872419 | 2.197528 | 2.446962 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000486
|
BRD-K33127281-001-05-6
|
ACH-000997
|
HCT15_LARGE_INTESTINE
|
HTS002
| 1 | 1.187498 | -0.471654 | 0.017114 | 1.067674 | 0.014506 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000997
|
BRD-K33127281-001-05-6
|
ACH-000796
|
MCAS_OVARY
|
HTS002
| 1 | 1.444754 | -0.466852 | 0.30402 | 1.210682 | 0.057044 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000796
|
BRD-K33127281-001-05-6
|
ACH-000652
|
SUIT2_PANCREAS
|
HTS002
| 1 | 0.767498 | 3.806956 | 0.097772 | 0.94473 | 0.995817 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000652
|
BRD-K33127281-001-05-6
|
ACH-000452
|
TE8_OESOPHAGUS
|
HTS002
| 1 | 4.810123 | -1.238865 | 0.2047 | 1.113524 | 0.000309 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000452
|
BRD-K33127281-001-05-6
|
ACH-000458
|
CJM_SKIN
|
HTS002
| 1 | 1.532221 | -0.325109 | -0.022916 | 1.168389 | 0.004668 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000458
|
BRD-K33127281-001-05-6
|
ACH-000221
|
SNU398_LIVER
|
HTS002
| 1 | 2.81473 | -0.224781 | 0.101099 | 1.585103 | 0.002112 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000221
|
BRD-K33127281-001-05-6
|
ACH-000893
|
NCIH1651_LUNG
|
HTS002
| 1 | 1.485045 | -0.394636 | 0.159637 | 1.143078 | 0.00474 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000893
|
BRD-K33127281-001-05-6
|
ACH-000562
|
HCC78_LUNG
|
HTS002
| 1 | 0.357949 | 3.237584 | 0.331655 | 0.891316 | 1.937563 | 2.858004 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000562
|
BRD-K33127281-001-05-6
|
ACH-000769
|
LK2_LUNG
|
HTS002
| 1 | 1.858075 | -1.616173 | 0.228697 | 1.511424 | 0.198556 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000769
|
BRD-K33127281-001-05-6
|
ACH-000505
|
RKN_SOFT_TISSUE
|
HTS002
| 1 | 2.631388 | -0.249397 | 0.082841 | 1.282827 | 0.00008 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000505
|
BRD-K33127281-001-05-6
|
ACH-000595
|
LN229_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 1.631091 | -3.104244 | 0.480951 | 1.464401 | 0.77071 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000595
|
BRD-K33127281-001-05-6
|
ACH-000052
|
A673_BONE
|
HTS002
| 1 | 0.274645 | 2.074671 | -0.151763 | 0.836695 | 1.130927 | 1.660571 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000052
|
BRD-K33127281-001-05-6
|
ACH-000571
|
T98G_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 0.158977 | 1.268776 | 0.610877 | 0.845515 | 1.834456 | 2.480214 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000571
|
BRD-K33127281-001-05-6
|
ACH-000812
|
COLO783_SKIN
|
HTS002
| 1 | 0.477249 | 7.760166 | 0.092925 | 0.9376 | 3.140039 | 4.675914 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000812
|
BRD-K33127281-001-05-6
|
ACH-000891
|
HCC1438_LUNG
|
HTS002
| 1 | 0.492882 | 4.33715 | -0.006863 | 0.980634 | 7.268736 | 19.374271 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000891
|
BRD-K33127281-001-05-6
|
ACH-000667
|
HCC44_LUNG
|
HTS002
| 1 | 0.649245 | 1.295481 | 0.388754 | 0.858067 | 0.197933 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000667
|
BRD-K33127281-001-05-6
|
ACH-000734
|
JHH5_LIVER
|
HTS002
| 1 | 0.745999 | 8.306608 | 0.165375 | 0.873276 | 0.078953 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000734
|
BRD-K33127281-001-05-6
|
ACH-000416
|
NCIH838_LUNG
|
HTS002
| 1 | 0.66068 | 2.671829 | 0.42726 | 0.899866 | 0.570681 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000416
|
BRD-K33127281-001-05-6
|
ACH-000802
|
BFTC905_URINARY_TRACT
|
HTS002
| 1 | 1.207505 | 0.03582 | -0.031902 | 1.11183 | 0.000992 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000802
|
BRD-K33127281-001-05-6
|
ACH-000946
|
HEC265_ENDOMETRIUM
|
HTS002
| 1 | 2.340904 | -0.419453 | 0.212441 | 1.482207 | 0.012825 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000946
|
BRD-K33127281-001-05-6
|
ACH-000472
|
HSC2_UPPER_AERODIGESTIVE_TRACT
|
HTS002
| 1 | 0.350448 | 3.863508 | 0.299324 | 0.932486 | 3.666597 | 5.011144 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000472
|
BRD-K33127281-001-05-6
|
ACH-000383
|
OE33_OESOPHAGUS
|
HTS002
| 1 | 0.033776 | 2.083539 | 0.242242 | 0.907932 | 4.277936 | 4.423979 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000383
|
BRD-K33127281-001-05-6
|
ACH-000824
|
KYSE510_OESOPHAGUS
|
HTS002
| 1 | 1.246671 | -0.089337 | 0.029154 | 1.120907 | 0.049925 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000824
|
BRD-K33127281-001-05-6
|
ACH-001307
|
8505C_THYROID
|
HTS002
| 1 | 2.192797 | 0.005656 | -0.034137 | 1.275593 | 16,844,645,894,500,500,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 | null |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-001307
|
BRD-K33127281-001-05-6
|
ACH-000756
|
GI1_CENTRAL_NERVOUS_SYSTEM
|
HTS002
| 1 | 0.312123 | 5.591713 | 0.255554 | 0.945057 | 4.617484 | 5.500826 |
adapalene
|
retinoid receptor agonist
|
RARA, RARB, RARG, RXRA, RXRB, RXRG
|
dermatology
|
acne vulgaris (AV)
|
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O, COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
|
Launched
| true |
ACH-000756
|
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