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The goal of this study is to determine how brain regions that respond strongly to different feature types (color and motion) and which encode spatial locations of visual stimuli transform 'feature dimension maps' based on stimulus properties as a function of task instructions. The investigators hypothesize that feature-selective brain regions act as neural feature dimension maps, and thus encode representations of relevant location(s) based on their preferred feature dimension, such that the stimulus representation in the most relevant feature map is up-regulated to support adaptive behavior. The investigators will scan healthy human participants using functional MRI (fMRI) in a repeated-measures design while they view visual stimuli made relevant based on a cued feature dimension (e.g., color or motion). The investigators will employ state-of-the-art multivariate analysis techniques that allow them to reconstruct an 'image' of the stimulus representation encoded by each brain region to dissect how neural tissue identifies salient locations. Each participant will perform a challenging discrimination task based on the cued feature (report motion direction or color of stimulus dots) of a stimulus presented in the periphery, which are identical across trial types. Across trials the investigators will manipulate the attended feature value (color, motion, or fixation point). This manipulation will help the investigators fully understand these critical relevance computations in the healthy human visual system. conditions: Basic Science: Visual Attention in Healthy Participants conditions: Basic Science: Neural Representations of Location studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a basic science study in which all participants will participate in all task conditions within each experiment (repeated-measures design). primaryPurpose: BASIC_SCIENCE masking: NONE maskingDescription: Participants will typically be unaware of the conditions presented, though because these involve manipulations of stimuli or task demands, they may be aware of the manipulation. This is not expected to impact the primary outcome measures (e.g., BOLD signal activation patterns). count: 10 type: ESTIMATED name: Stimulus properties: task-defining feature measure: Blood Oxygenation Level Dependent (BOLD) fMRI signal measure: Gaze position measure: Behavioral response (button press) sex: ALL minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: University of California, Santa Barbara status: RECRUITING city: Santa Barbara state: California zip: 93117 country: United States name: Melodie Blakemore role: CONTACT phone: 805-893-4286 email: blakemore@research.ucsb.edu name: Tommy C Sprague, PhD role: PRINCIPAL_INVESTIGATOR lat: 34.42083 lon: -119.69819 hasResults: False
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<|newrecord|> nctId: NCT06281444 id: i07-453-23 briefTitle: Effectiveness of Radial Extracorporeal Shock Wave Therapy in Patients With Knee Osteoarthritis overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-31 date: 2025-07-31 date: 2024-02-28 date: 2024-02-28 name: Ankara University class: OTHER briefSummary: Osteoarthritis (OA) is a degenerative joint disease characterized by unsuccessful repair of joint damage resulting from stresses in any of the synovial joint tissues. Symptoms include pain (initially only after movement), joint stiffness, limitation of joint movement, feeling of insecurity in the joint, and difficulty walking. The diagnosis of knee osteoarthritis can be easily made with a detailed history and a comprehensive physical examination. Radiographic examinations are used to support clinical findings and exclude other possible pathologies. The main purpose of treating knee osteoarthritis is to reduce pain and make daily life easier. Since there is no standard treatment method, the patient's treatment must be individualized by taking into account age, comorbidity, severity of the clinical picture, patient preferences and cost of treatment. Conservative treatment includes pharmacological and non-pharmacological treatment, and the optimal treatment should be applied as a combination of these two methods. Patient education, lifestyle modification, exercise, different physical therapy modalities (TENS, Interferential current, ESWT...), acupuncture are some non-pharmacological methods.
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Extracorporeal shock wave therapy (ESWT), which is considered within the scope of conservative treatment, started in the seventies with the practice of breaking ureteric stones and has become one of the physical therapy modalities used in the treatment of various musculoskeletal diseases. Considering the historical development of ESWT, it has started to be used as a therapeutic modality in the treatment of knee osteoarthritis in recent years. The process, which started with animal experiments, continued with human studies, and evidence is presented that ESWT reduces knee pain and contributes to functionality. It is noteworthy that there are few studies and their short follow-up periods. In the light of these studies, it was planned to investigate the effectiveness of ESWT treatment, which will be applied together with exercise, on pain, functionality and walking distance in individuals diagnosed with knee osteoarthritis, in comparison with the control group receiving sham ESWT. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients who accepted to participate in the study by meeting the criteria will be randomly divided into two groups as the first group treatment ESWT + exercise, the second group sham ESWT + exercise. primaryPurpose: TREATMENT masking: NONE maskingDescription: Patients who meet the study conditions and agree to participate in this study will not know whether they are in the first group or the second group. count: 72 type: ESTIMATED name: ESWT name: Sham-ESWT measure: Change in pain [by using the Visual Analogue Scale(VAS)] measure: Change from baseline in functionality and walking distance measure: Change from baseline in walking distance sex: ALL minimumAge: 50 Years maximumAge: 85 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ankara University status: RECRUITING city: Ankara state: Altındağ zip: 06230 country: Turkey name: Birkan Sonel Tur, Prof. Dr. role: CONTACT phone: +903125956331 email: sonelb@medicine.ankara.edu.tr name: Taha Can Başar, Dr. role: CONTACT phone: +90312595 6331/2822 email: tahacan06@outlook.com name: Birkan Sonel Tur, Prof. Dr. role: PRINCIPAL_INVESTIGATOR name: Taha Can Başar, Dr. role: SUB_INVESTIGATOR lat: 39.91987 lon: 32.85427 hasResults: False
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<|newrecord|> nctId: NCT06281431 id: CPSP briefTitle: A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain overallStatus: RECRUITING date: 2023-06-12 date: 2025-09-30 date: 2025-09-30 date: 2024-02-28 date: 2024-02-28 name: The Second Affiliated Hospital of Chongqing Medical University class: OTHER briefSummary: Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. \>20% of patients suffer from chronic postoperative pain. China has \>70 million surgeries yearly. Nerve block manages postoperative pain, with developing nerve block needles now used in clinics. Developed needles may have better pain management effects than non-developed ones, but their effect on reducing chronic pain remains unclear. This study aims to explore the effect of developed nerve block needles on postoperative pain and compare them to non-developed needles, providing new ideas and methods for pain management. conditions: Chronic Postoperative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 1000 type: ESTIMATED name: Echogenic nerve block needle name: Non-echogenic nerve block needle measure: Chronic postoperative pain measure: Moderate to severe pain measure: Acute postoperative pain measure: Acute postoperative pain measure: Acute postoperative pain measure: Puncture operation time measure: Number of needle passes sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: He Huang status: RECRUITING city: Chongqing state: Chongqing zip: 4000000 country: China name: He Huang, ph.D role: CONTACT phone: 13708385559 email: huanghe@cqmu.edu.cn lat: 29.56278 lon: 106.55278 hasResults: False
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<|newrecord|> nctId: NCT06281418 id: 5-24 briefTitle: Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy overallStatus: RECRUITING date: 2024-02-29 date: 2024-10 date: 2024-10 date: 2024-02-28 date: 2024-04-17 name: Future University in Egypt class: OTHER briefSummary: Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC. conditions: Post Operative Pain studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: Granisetron 1 Mg/mL Intravenous Solution name: Normal saline measure: VAS score measure: Time to analgesic request measure: Quality of life (QoL) after laparoscopic cholecystectomy (LC) sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Hepatology and Tropical Research Institute status: RECRUITING city: Cairo zip: 11617 country: Egypt name: Hoda Mohamed Bayoumi, Bachelor's role: CONTACT phone: 01126143971 email: hoda.bayoumy@fue.edu.eg lat: 30.06263 lon: 31.24967 hasResults: False
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<|newrecord|> nctId: NCT06281405 id: FDRT-2023-290-3409 briefTitle: CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer acronym: TORCH-iTNT overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-06-30 date: 2028-12-31 date: 2024-02-28 date: 2024-02-28 name: Fudan University class: OTHER briefSummary: TORCH-iTNT is a prospective, multicentre, randomized phase II trial. 198 LARC (T3-4/N+M0, distance from anal verge ≤12cm) patients will be treated with total neoadjuvant therapy (TNT) and assigned to Group A and Group B (1:1). Group A receives 6 cycles of Toripalimab combined with CAPOX (ToriCAPOX). Group B receives SCRT (25Gy/5Fx) followed by 6 cycles of ToriCAPOX. TME surgery is scheduled after TNT while a watch and wait (W\&W) option can be applied to patients achieving clinical complete response (cCR). The primary endpoint is complete response (CR, pathological complete response \[pCR\] plus cCR) rate. The secondary endpoints include the grade 3-4 acute adverse effects (AE) rate, anal preservation rate, 3-year DFS rate, etc. conditions: Locally Advanced Rectal Cancer conditions: Neoadjuvant Therapy studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 198 type: ESTIMATED name: PD-1 antibody name: Capecitabine name: Short-course radiotherapy measure: Complete response (CR) rate measure: Grade 3-4 adverse effects rate measure: 3 year anal preservation rate measure: 3 year disease free survival rate measure: 3 year local recurrence free survival rate measure: 3 year overall survival rate measure: Rate of surgical complications sex: ALL minimumAge: 18 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Fudan University Shanghai Cancer Center city: Shanghai country: China lat: 31.22222 lon: 121.45806 hasResults: False
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<|newrecord|> nctId: NCT06281392 id: CEIm: 106/23 briefTitle: Artificial Intelligence and Dysplasia Detection in Inflammatory Bowel Disease (EIIDISIA Study) overallStatus: RECRUITING date: 2023-11-15 date: 2026-11-15 date: 2026-11-15 date: 2024-02-28 date: 2024-02-28 name: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana class: OTHER name: University of Valencia briefSummary: Randomized clinical study analyzing the efficacy of colonoscopy assisted by the Computer Aided Detection (CADe) system compared to virtual chromoendoscopy with Narrow Band Imaging (NBI) in the detection of colon dysplasia in patients with long-standing inflammatory bowel disease (IBD). conditions: Inflammatory Bowel Diseases conditions: Dysplasia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SCREENING masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 122 type: ESTIMATED name: CADe system name: NBI measure: "Per lesion" dysplasia detection rate (DDR) measure: "Per patient" dysplasia detection rate (DDR) measure: Duration of endoscopic examination sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Antonio López-Serrano status: RECRUITING city: Valencia zip: 46017 country: Spain name: Antonio López-Serrano, Ph.D. role: CONTACT phone: 0034656495490 email: anlopezs@comv.es lat: 39.46975 lon: -0.37739 hasResults: False
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<|newrecord|> nctId: NCT06281379 id: Basaksehir City Hospital briefTitle: Complete Mesogastric Excision With D2 Lympadenectomy for Gastric Cancer: overallStatus: COMPLETED date: 2023-04-01 date: 2023-12-31 date: 2024-01-01 date: 2024-02-28 date: 2024-02-28 name: Başakşehir Çam & Sakura City Hospital class: OTHER_GOV briefSummary: Objective: To define complete mesogastric excision and compare our short term results for the first time in a different population.
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Study design:Randomised-controlled study
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Place and duration of the study: Gastroenterological Surgery Clinic,Health Sciences University,Basaksehir City Hospital,Istanbul,Turkey,from April to December 2023.
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Methodology: We compared short term results of open total gastrectomy+ mesogastrectomy with standard total gastrectomy + D2 lymph node dissection at a tertiary center in terms of peroperative results, histopathological findings and postoperative short- term outcomes with review of the literature.
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Conclusion: Our aim is to show that mesogastric excision is safe and has advantages over conventional D2 gastrectomy in means of not only peroperative and short-term outcomes, but also disease free survival.Our work is the first study from a different population of the world and our initial results can contribute to the literature for universalization. conditions: Gastric Cancer conditions: Gastric Neoplasm conditions: Gastric Cancer Stage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Study group participants: total gastrectomy+mesogastrectomy Control group: Standard total gastrectomy + D2 lymph node dissection primaryPurpose: TREATMENT masking: NONE count: 37 type: ACTUAL name: Total mesogastrectomy measure: Postoperative outcome sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Yigit Duzkoylu city: Istanbul zip: 34480 country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
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<|newrecord|> nctId: NCT06281366 id: PR(AMI)470-2023 briefTitle: Diamine Oxidase and Adverse Pregnancy Outcomes overallStatus: RECRUITING date: 2024-02-16 date: 2025-12-31 date: 2025-12-31 date: 2024-02-28 date: 2024-03-20 name: Hospital Universitari Vall d'Hebron Research Institute class: OTHER name: DR Healthcare briefSummary: In normal pregnancies, blood histamine concentration remains within normal values; however, the serum histaminolytic activity is increased. Histamine is mainly produced by mast cells, platelets, basophils, neurons and enterochromatin cells, where it is stored and released when required. Reduced DAO activities have been found in high-risk pregnancies. Lower DAO activity has been associated to miscarriage, fetal demise, preeclampsia, low birthweight and preterm birth. The placenta is very rich in DAO activity and is the principal source of increased histaminolytic activity in normal pregnancies.
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First-trimester screening for preeclampsia (PE) is a routine screening which is performed in the first trimester. Women with a positive result are at a greater risk of PE but also other pregnancy complications such as stillbirth, preterm birth and low birthweight. These cases are prescribed aspirin until term. This intervention has demonstrated to significantly reduce the risk of PE and other complications. Unfortunately, aspirin does not avoid all cases with adverse outcomes, indicating that additional mechanisms may be involved in the development of such pregnancy complications, such as DAO decreased activity. conditions: Pregnancy Complications studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 75 type: ESTIMATED measure: Diamine oxidase activity first trimester measure: Diamine oxidase gene polymorphisms measure: Blood Diamine oxidase activity at delivery measure: Placental Diamine oxidase activity at delivery measure: Blood histamine levels at delivery measure: Placental histamine levels at delivery measure: Urine histamine levels at delivery sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Manel Mendoza status: RECRUITING city: Barcelona zip: 08035 country: Spain name: Manel Mendoza, PhD role: CONTACT phone: +34934893085 email: manel.mendoza@vallhebron.cat name: Erika Bonacina, PhD role: CONTACT phone: +34934893264 email: erika.bonacina@vallhebron.cat name: Erika Bonacina, PhD role: SUB_INVESTIGATOR name: Manel Mendoza, PhD role: PRINCIPAL_INVESTIGATOR name: Mireia Armengol, MD role: SUB_INVESTIGATOR lat: 41.38879 lon: 2.15899 hasResults: False
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<|newrecord|> nctId: NCT06281353 id: 22-07-0754 briefTitle: The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue overallStatus: COMPLETED date: 2022-08-16 date: 2023-09-06 date: 2023-09-06 date: 2024-02-28 date: 2024-02-28 name: Indonesia University class: OTHER briefSummary: The goal of this clinical trial is to demonstrate the adjuvant administration of oral nanocurcumin in 90% TCA therapy that increases the proportion of clinical improvement in patients with Anogenital Warts (AGW), mediated by NFĸB, IFN-γ, and FOXP3+Treg. Specific objectives of this clinical trial include:
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* To prove that the oral administration of nanocurcumin decreases the levels of IFN-γ, FOXP3+Treg, and NFĸB in lesions of AGW patients, and
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* To demonstrate that the reduction in IFN-γ, FOXP3+Treg, and NFĸB levels in lesions is associated with the proportion of clinical improvement in AGW patients undergoing TCA 90% therapy with adjuvant of oral nanocurcumin.
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The main questions it aims to answer are:
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* Does adjuvant oral nanocurcumin administration in 90% TCA therapy increase the proportion of clinical improvement in patients with AGW compared to controls (90% TCA therapy alone)?
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* Is there a greater decrease in IFN-γ, FOXP3+Treg, and NFĸB levels in lesions of patients with AGW given adjuvant oral nanocurcumin compared to controls?
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* Is the decrease in IFN-γ, FOXP3+TReg, and NFĸB levels in lesions of patients with AGW, with adjunctive oral nanocurcumin administration in 90% TCA therapy, associated with the degree of clinical improvement in patients with AGW?
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Participants will be divided into 2 groups. The first one was given capsules without active ingredients/nanocurcumin (control group), and the second one was given capsules with nanocurcumin (experimental group), both group received a dosage of 200mg capsules per day after breakfast, for 8 weeks. The researchers conducted a comparison between those 2 groups to assess whether the adjuvant administration of oral nanocurcumin in 90% TCA therapy enhances the proportion of clinical improvement in patients with AGW. conditions: Anogenital Wart studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 78 type: ACTUAL name: Curcumin Oral Capsule name: Trichloroacetic acid name: Blood sample collection name: Cotton swab measure: Clinical improvement in patients with AGW measure: Level of IFN-γ in lesions of AGW patients measure: Level of FOXP3+Treg in lesions of AGW patients measure: Level of NFĸB in lesions of AGW patients sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT facility: Cipto Mangunkusumo Hospital city: Jakarta Pusat state: DKI Jakarta zip: 10430 country: Indonesia lat: -6.1818 lon: 106.8223 hasResults: False
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<|newrecord|> nctId: NCT06281340 id: He-ankle US briefTitle: Changes in Intra-articular Parameters by Doppler Ultrasound in Patients With Hemophilic Ankle Arthropathy overallStatus: NOT_YET_RECRUITING date: 2024-02-28 date: 2024-04-10 date: 2024-04-21 date: 2024-02-28 date: 2024-02-28 name: Investigación en Hemofilia y Fisioterapia class: NETWORK briefSummary: Introduction: Hemophilic ankle arthropathy is manifested by functional degenerative alterations, intra-articular alterations, and chronic pain. Manual therapy techniques are used in the treatment of hemophilic ankle arthropathy for the improvement of pain and mobility.
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Design. Double-blind randomized pilot trial. Aimed: To evaluate the ultrasound changes by means of Doppler imaging after manual therapy intervention.
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Patients: A total of 20 adult patients with hemophilic ankle arthropathy will be recruited.
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Intervention: Each manual therapy session will last approximately 50 minutes, with 1 session per week for a period of 3 weeks. The treatment program includes 10 techniques that will be administered bilaterally.
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Measuring instruments: Patients will be evaluated qualitatively with ultrasound (HEAD-US scale) and assessment with Doppler ultrasound. The clinical variables will be joint damage (Hemophilia Joint Health Score) and pain intensity (Visual Analogue Scale).
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Expected results: Check the safety of manual therapy in patients with hemophilia regarding subclinical bleeding. Assess changes related to joint inflammatory state with imaging techniques. Observe changes in pain intensity and joint damage. conditions: Hemophilia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: DOUBLE maskingDescription: Randomization will be performed using a computerized randomization procedure by permuted blocks of 4 subjects in each recruitment center. The 6 possible sequence alternatives will be modified in each block. This task will be carried out by a person who is not involved in the study and who will not know the identity of the subjects. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 20 type: ESTIMATED name: Manual therapy name: Placebo therapy measure: Change from baseline sonographic changes after 4 hours measure: Change from baseline joint pain after 4 hours measure: Change from baseline joint damage after 4 hours measure: Change from baseline degree of joint inflammation after 4 hours sex: MALE minimumAge: 30 Years maximumAge: 55 Years stdAges: ADULT facility: University of Oviedo city: Oviedo state: Asturias zip: 33006 country: Spain lat: 43.36029 lon: -5.84476 hasResults: False
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<|newrecord|> nctId: NCT06281327 id: TX-ITP-001 briefTitle: Avatrombopag in the Treatment of Pediatric Immune Thrombocytopenia overallStatus: RECRUITING date: 2024-03 date: 2025-12 date: 2025-12 date: 2024-02-28 date: 2024-02-28 name: Institute of Hematology & Blood Diseases Hospital, China class: OTHER name: Henan Cancer Hospital name: Tianjin Medical University Second Hospital name: Tianjin Children's Hospital name: The Second Affiliated Hospital of Kunming Medical University briefSummary: To evaluate the safety and efficacy of avatrombopag in the treatment of pediatric primary immune thrombocytopenia in patients who have been treated with eltrombopag before and switched to avatrobopag because of poor efficacy, excessive platelet fluctuation or intolerance, or patient preference, economic reasons, and other reasons. conditions: Immune Thrombocytopenia conditions: Treatment studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 60 type: ESTIMATED name: Avatrombopag measure: Overall efficacy response after AVA treatment within 12 weeks measure: Treatment response-1 measure: Treatment response-2 measure: Time to Response measure: Persistent response measure: Emergency treatment measure: Reduction of concomitant drug measure: Number of participants with clinically significant bleeding as assessed using the world health organization (WHO) bleeding scale. measure: Number of participants with clinically significant bleeding as assessed using the bleeding scale for pediatric patients with ITP. measure: Health-related quality of life survey of subjects(HRQoL)-1 measure: Health-related quality of life survey of subjects(HRQoL)-2 measure: Health-related quality of life survey of subjects(HRQoL)-3 measure: Health-related quality of life survey of subjects(HRQoL)-4 sex: ALL minimumAge: 6 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College status: RECRUITING city: Tianjin country: China name: Lei Zhang, MD role: CONTACT phone: +8602223909009 email: zhanglei1@ihcams.ac.cn name: Ting Sun, MD role: CONTACT phone: +8602223909009 email: sunting@ihcams.ac.cn lat: 39.14222 lon: 117.17667 hasResults: False
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<|newrecord|> nctId: NCT06281314 id: VESPA 2.0 briefTitle: The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment overallStatus: COMPLETED date: 2021-03-01 date: 2022-12-27 date: 2023-12-31 date: 2024-02-28 date: 2024-03-08 name: IRCCS Centro Neurolesi "Bonino-Pulejo" class: OTHER briefSummary: VESPA 2.0 is based on an integrative and ecological approach used for the treatment of cognitive dysfunction in patients with MCI or other neurodegenerative disorders. conditions: Neurodegenerative Diseases conditions: Cognitive Decline conditions: Parkinson Disease Dementia conditions: Alzheimer Disease conditions: Multiple Sclerosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ACTUAL name: Vespa software measure: Montreal cognitive assessment (MoCA) sex: ALL minimumAge: 50 Years maximumAge: 70 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Centro Neurolesi Bonino Pulejo city: Messina state: Sicily zip: 98124 country: Italy lat: 38.19394 lon: 15.55256 hasResults: False
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<|newrecord|> nctId: NCT06281301 id: HSC-MS-23-1023 briefTitle: Improving Patient Understanding of Macrosomia overallStatus: RECRUITING date: 2024-01-30 date: 2024-04-30 date: 2024-09-01 date: 2024-02-28 date: 2024-02-28 name: The University of Texas Health Science Center, Houston class: OTHER briefSummary: The purpose of this study is to evaluate the effectiveness of a graphic based education tool on patient knowledge of macrosomia through the use of a survey and to evaluate knowledge at 1-2 weeks after initial review of the education tool. conditions: Macrosomia, Fetal studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 176 type: ESTIMATED name: education tool name: no additional information measure: Number of participants that showed Macrosomia knowledge greater than 50 percent as assessed by the score on a survey sex: FEMALE minimumAge: 18 Years maximumAge: 55 Years stdAges: ADULT facility: The University of Texas Health Science Center at Houston status: RECRUITING city: Houston state: Texas zip: 77030 country: United States name: Kristen Cagino, MD role: CONTACT phone: 713-500-6412 email: Kristen.A.Cagino@uth.tmc.edu name: Suneet Chauhan role: CONTACT email: mfmchauhan@gmail.com lat: 29.76328 lon: -95.36327 hasResults: False
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<|newrecord|> nctId: NCT06281288 id: P.T.REC/012/004754 briefTitle: Cognitive-Behavioral Therapy With Exercise Training in Adolescent Females With Elevated Depression Symptoms overallStatus: ENROLLING_BY_INVITATION date: 2023-12-25 date: 2024-03 date: 2024-03 date: 2024-02-28 date: 2024-03-19 name: Doaa Tammam Atia class: OTHER briefSummary: PURPOSE: To Study the Effect of Cognitive-behavioral therapy combined with exercise training in adolescent females with elevated depression symptoms
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BACKGROUND: Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers" are preying on them. Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers"
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RESEARCH QUESTION: Is there is an effect of exercise on depression in adolescent girls. conditions: Depression studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL primaryPurpose: PREVENTION masking: TRIPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Cognitive-Behavioral Therapy name: Exercise Training measure: Center for Epidemiological Studies Depression Scale for Children (CES-DC), sex: FEMALE minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: doaa Tammam Atia city: Suez country: Egypt lat: 29.97371 lon: 32.52627 hasResults: False
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<|newrecord|> nctId: NCT06281275 id: TJ-IRB202402008 briefTitle: A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-12 date: 2024-09-30 date: 2024-10-30 date: 2024-02-28 date: 2024-04-12 name: Huazhong University of Science and Technology class: OTHER briefSummary: To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms, to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients, and consequently improve their quality of life and mental status. conditions: Frailty conditions: Acute Postoperative Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 78 type: ESTIMATED measure: All patients' Numerical Rating Scale （NRS） scores for most significant pain at rest in the 48h postoperative period measure: Numerical Rating Scale （NRS） scores for the most pronounced pain in the patient's coughing state in the 48h postoperative period measure: PCA pump consumption measure: Number of PCA pump presses sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 hasResults: False
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<|newrecord|> nctId: NCT06281262 id: GIP-23-L-04-223 briefTitle: Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia acronym: PRIME overallStatus: RECRUITING date: 2023-06-30 date: 2025-03-30 date: 2025-03-30 date: 2024-02-28 date: 2024-03-01 name: General University Hospital, Prague class: OTHER name: Charles University, Czech Republic name: Institute of Hematology and Blood Transfusion, Czech Republic briefSummary: The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the expression of individual regulatory molecules of T-regulatory lymphocytes according to new paradigms. The proportional and functional characteristics of T-regulatory lymphocytes will be correlated with the composition of the intestinal and vaginal microbiota. conditions: Preterm Birth conditions: Preeclampsia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: Peripheral blood collection name: Swab sample collection measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent spontaneous preterm birth measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent pre-eclampsia measure: Association of maternal microbiota and maternal T regulatory cell populations. sex: FEMALE minimumAge: 19 Years maximumAge: 40 Years stdAges: ADULT facility: Department of Gynaecology, Obstetrics and Neonatology of the First Faculty of Medicine of the Charles University and General University Hospital in Prague status: RECRUITING city: Prague zip: 128 08 country: Czechia name: Zdeněk Laštůvka, MUDr., Ph.D. role: CONTACT phone: +420777724640 email: zdenek.lastuvka@vfn.cz name: Michal Koucký, Doc., MUDr., Ph.D. role: CONTACT phone: +420603219916 email: michal.koucky@vfn.cz lat: 50.08804 lon: 14.42076 hasResults: False
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<|newrecord|> nctId: NCT06281249 id: 73172 briefTitle: Neuraxial Ultrasound Device Study overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03 date: 2025-03 date: 2024-02-28 date: 2024-03-15 name: Stanford University class: OTHER name: Rivanna Medical, Inc. briefSummary: The aim of the study is to develop a device that can eliminate failed neuraxial placements in challenging patients.The study will attempt to improve safety and efficacy of neuraxial anesthesia with high precision real-time needle visualization through automated real-time needle guidance at the bedside with an experimental device (Accuro 3S). Investigators will verify the clinical workflow for utilizing the Accuro 3S during epidural and spinal procedures and validation of needle visualization while using the device as well as anatomical guidance provided by the device during spinal imaging.The underlying bone imaging enhancement algorithms were introduced in the commercially available FDA approved Accuro. The Accuro 3S will be used to establish needle insertion point and trajectory, after which the clinician will use standard of care methods to advance the needle such as the loss of resistance method. conditions: Labor Pain conditions: Cesarean Delivery Regional Anesthesia Induction studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 100 type: ESTIMATED name: Ultrasound placement device measure: Incidence of difficult block placement measure: Incidence of failed block measure: Incidence of post-dural puncture headache sex: FEMALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Stanford University city: Stanford state: California zip: 94305 country: United States lat: 37.42411 lon: -122.16608 hasResults: False
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<|newrecord|> nctId: NCT06281236 id: SPI-62-CL-1002 briefTitle: A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-10-01 date: 2024-10-01 date: 2024-02-28 date: 2024-02-28 name: Sparrow Pharmaceuticals class: INDUSTRY briefSummary: This will be an open label phase 1b trial to characterize the pharmacodynamics and PK of prednisolone and SPI-62 when co-administered to participants with PMR. Up to 24 participants could be recruited. conditions: Polymyalgia Rheumatica studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 24 type: ESTIMATED name: Prednisolone name: SPI-62 measure: Erythrocyte sedimentation rate measure: C-reactive protein measure: Plasma fibrinogen sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Emovis Gmbh city: Berlin country: Germany name: Anna Wieczorek role: CONTACT phone: +49 30 439741221 email: anna.wieczorek@futuremeds.com name: Frank Zollmann role: PRINCIPAL_INVESTIGATOR lat: 52.52437 lon: 13.41053 facility: Klinische Forschung Hannover Mitte GmbH/Pratia city: Hannover zip: 30159 country: Germany name: Matilde Planer role: CONTACT phone: +49 511 169 7650 email: matilde.planer@pratia.com name: Jan Wagner role: PRINCIPAL_INVESTIGATOR lat: 52.37052 lon: 9.73322 facility: Klinische Forschung Schwerin GmbH/Pratia city: Schwerin zip: 19055 country: Germany name: Julia Grindel role: CONTACT phone: +49 385 557 740 email: julia.grindel@pratia.com name: Charlotte von Engelhardt role: PRINCIPAL_INVESTIGATOR lat: 53.62937 lon: 11.41316 hasResults: False
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<|newrecord|> nctId: NCT06281223 id: JBR_2023_9 briefTitle: Study of Brain-spinal Cord Neural Connectivity in Spasticity acronym: MOVE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-05 date: 2026-05 date: 2024-02-28 date: 2024-02-28 name: Fondation Ophtalmologique Adolphe de Rothschild class: NETWORK briefSummary: Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic. conditions: Spasticity, Muscle studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: intraoperative neuroelectrophysiological monitoring measure: variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery sex: ALL minimumAge: 3 Years maximumAge: 17 Years stdAges: CHILD hasResults: False
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<|newrecord|> nctId: NCT06281210 id: IEO 2034 briefTitle: Vabb After Neoadjuvant Therapy to Avoid Surgery-pCR to Avoid Breast Surgery acronym: BETTY-CRASY overallStatus: RECRUITING date: 2023-12-11 date: 2028-12-31 date: 2028-12-31 date: 2024-02-28 date: 2024-02-28 name: European Institute of Oncology class: OTHER briefSummary: This single arm study aims to evaluate the efficacy and safety of a non-surgical approach, consisting of radiotherapy (RT) alone, for patients who have achieved a complete pathological response (pCR) following neoadjuvant chemotherapy (NACT). The study design involves the histological confirmation of pCR using vacuum-assisted biopsy (VABB) or vacuum-assisted excision (VAE) guided by ultrasound. The primary objective is to demonstrate that the non-surgical, RT-only treatment and follow-up approach is not inferior to the traditional surgical approach in patients with pCR after NACT. conditions: Breast Cancer conditions: Triple Negative Breast Cancer conditions: HER2-positive Breast Cancer conditions: Neoadjuvant Chemotherapy studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 77 type: ESTIMATED name: Omission of surgical treatment measure: Event-free survival measure: Positive predictive value of MRI measure: Contrast-Enhanced Mammography (CEM) positive predictive value sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Istituto di Candiolo IRCCS status: NOT_YET_RECRUITING city: Candiolo state: Turin zip: 10060 country: Italy name: Antonio Toesca, MD role: CONTACT lat: 44.95858 lon: 7.59812 facility: European Institute of Oncology status: RECRUITING city: Milan zip: 20141 country: Italy name: Elisabetta Rossi, MD role: CONTACT phone: +390294372191 email: ElisabettaMariaCristina.Rossi@ieo.it name: Mara Negri role: CONTACT email: mara.negri@ieo.it name: Elisabetta Rossi, MD role: PRINCIPAL_INVESTIGATOR lat: 45.46427 lon: 9.18951 hasResults: False
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<|newrecord|> nctId: NCT06281197 id: 2021/48 briefTitle: Does Subspinal Le Fort I Osteotomy Affect the Nasal Airway Volume overallStatus: COMPLETED date: 2021-01-15 date: 2021-08-15 date: 2022-05-15 date: 2024-02-28 date: 2024-02-28 name: TC Erciyes University class: OTHER briefSummary: After the description of Le Fort fractures, maxillary osteotomies are used to correct dentofacial deformities. The profile changes on nasolabial region resulting from a Le Fort I osteotomy, also that affects nasal airway. The Subspinal Le Fort I osteotomy (SLFIO) describe to prevent undesirable soft tissue changes. In the literature, too many articles have reported the effectiveness of SLFIO in preventing nasal deformation. However, there is no study to evaluate the nasal volume or septum deviation. conditions: Maxillofacial Abnormalities studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: double blind primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: double blind whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 47 type: ACTUAL name: Conventional name: Subspinal measure: Evaluation of Septum Deviation measure: Evaluation of Nasal Airway measure: nasal obstruction scale evaluation sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Selin Çelebi city: Kayseri state: Meligazi zip: 38320 country: Turkey lat: 38.73222 lon: 35.48528 hasResults: False
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<|newrecord|> nctId: NCT06281184 id: DIA2024.1 id: 715758 type: REGISTRY domain: Regional committee for medical and health research ethics briefTitle: A Post-trial Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate Treatment in Adults With Erosive Hand OA. acronym: MERINO:2 overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-02-01 date: 2027-02-01 date: 2024-02-28 date: 2024-02-28 name: Diakonhjemmet Hospital class: OTHER briefSummary: In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there\&#39;s a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA. Recent guidelines highlight the need for large, well-designed trials to assess the effectiveness of MTX. A recent trial (METHODS study) showed promising pain reduction with MTX, but due to pandemic-related protocol changes, the duration of the study was limited to six months. The ongoing MERINO trial randomizes participants to MTX or placebo for one year. After completing the MERINO trial, several participants asked for MTX open label. In the subsequent MERINO:2 study, participants completing the trial will be invited to a structured follow-up after one year, including electronic questionnaires and hand radiographs, providing valuable long-term data on the effects of MTX in hand OA. Together, these trials aim to fill gaps in understanding the long-term impact of MTX in hand OA, particularly on structural progression. conditions: Hand Osteoarthritis conditions: Erosive Osteoarthritis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 108 type: ESTIMATED name: Methotrexate name: No treatment measure: Effect of MTX on radiographic progression of erosive hand OA. measure: Effect of MTX on pain, function and life quality measure: Effect of MTX on radiographic progression of hand OA. sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Diakonhjemmet Hospital city: Oslo zip: 0319 country: Norway name: Ida Løchting role: CONTACT phone: +4722451500 email: Ida.Lochting@diakonsyk.no name: Alexander Mathiessen, MD PhD role: PRINCIPAL_INVESTIGATOR lat: 59.91273 lon: 10.74609 hasResults: False
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<|newrecord|> nctId: NCT06281171 id: 90BISB0022 briefTitle: Evaluation of SkillTalk for Autistic Young Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-01 date: 2024-07-31 date: 2024-08-31 date: 2024-02-28 date: 2024-04-17 name: dfusion Inc class: INDUSTRY briefSummary: The goal of this clinical trial is to evaluate the effectiveness of using a Microskills video training library for young adults, aged 18-28, with autism spectrum disorder (ASD) to enhance their skills in developing and maintaining healthy relationships.
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The main questions it aims to answer are:
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* Does using SkillTalk increase autistic young adults skills in the communications skills that are demonstrated in the video curriculum (skills: resolve conflict, compromise, give feedback)?
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* Does using SkillTalk increase reported confidence and satisfaction in communication and relationship skills?
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* Does using SkillTalk increase interpersonal competence?
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* Does using SkillTalk increase ability to cope with rejection?
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* Does using SkillTalk improve mental health and wellbeing?
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Participants will be asked to:
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* Take a survey at the beginning of the study, after one month the end of the study, and at 3-month follow up
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* Participate in recorded video calls with projects staff, comprised of 2-3 brief roleplay scenarios of relationship skills at the beginning of the study, after one month the end of the study, and at 3-month follow up
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* Watch a minimum of 85% of the 60 minutes of video assigned conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 110 type: ESTIMATED name: SkillTalk for Autistic Young Adults name: Flyer Library measure: Demonstrated Skill Score in communication skills. measure: Participant Confidence & Satisfaction in their communication skills measure: Interpersonal Competence Score measure: Coping with Rejection, Jealousy and Relationship Anxiety measure: Mental Health and Wellbeing sex: ALL minimumAge: 18 Years maximumAge: 28 Years stdAges: ADULT facility: Virtual Study city: Santa Cruz state: California zip: 95060 country: United States lat: 36.97412 lon: -122.0308 hasResults: False
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<|newrecord|> nctId: NCT06281158 id: DNLI-F-0009 briefTitle: A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-DNL343 Following a Single Oral Dose in Healthy Male Participants overallStatus: RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-02-28 date: 2024-03-01 name: Denali Therapeutics Inc. class: INDUSTRY briefSummary: This is a Phase 1, open-label, nonrandomized, single-dose study in healthy male participants to investigate the absorption, metabolism and excretion of DNL343. conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 7 type: ESTIMATED name: [14C]-DNL343 measure: PK Parameter: AUC0-∞ measure: PK Parameter: AUC0-tlast measure: PK Parameter: Cmax measure: PK Parameter: Tmax measure: PK Parameter: t1/2 measure: Total radioactivity in plasma and whole blood measure: Total radioactivity in blood-to-plasma ratio measure: Extent and rate of recovery of total radioactivity in urine and feces measure: PK Parameter: AUC0-∞ measure: PK Parameter: AUC0-tlast measure: PK Parameter: Cmax measure: PK Parameter: Tmax measure: PK Parameter: t1/2 measure: DNL343 and a DNL343 metabolite recoveries in urine measure: Incidence, severity, and seriousness of treatment-emergent adverse events (TEAEs) sex: MALE minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Clinical Site status: RECRUITING city: Madison state: Wisconsin zip: 53704 country: United States lat: 43.07305 lon: -89.40123 hasResults: False
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<|newrecord|> nctId: NCT06281145 id: RSV-SK001/UC-SK004/OUSA briefTitle: Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer acronym: SRI-BrCa_CRC overallStatus: RECRUITING date: 2024-03-15 date: 2027-03-15 date: 2029-03-15 date: 2024-02-28 date: 2024-02-28 name: Comenius University class: OTHER briefSummary: The goal of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in 2 cohorts of patients. Cohort A will evaluate the effect of the addition of HRV BI in patients with breast cancer treated in the neoadjuvant setting (vs. standard of care alone, SOC) followed by local therapy (surgery +/-radiotherapy). Cohort B will evaluate the effect of the addition of HRV BI in patients with colon cancer after surgery in the adjuvant setting (vs. standard of care alone, SOC). conditions: Breast Cancer conditions: Colon Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study consists of two cohorts (breasts cancer and colorectal cancer) with two arms SOC + intervention vs SOC alone. primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 100 type: ESTIMATED name: Heart-rate variability biofeedback intervention measure: Primary endpoint - inflammation measure: Primary endpoint - QoL measure: Primary endpoint - executive functions measure: Primary endpoint- salivary cortisol slopes measure: Primary endpoint- sleep quality measure: Primary endpoint - heart rate variability (HRV) measure: Primary endpoint - Working memory measure: Secondary endpoint - Pathologic Complete Response (pCR) and Residual Cancer Burden (RCB) rate in cohort A measure: Secondary endpoint - Relapse-free Survival (RFS) measure: Secondary endpoint - Overall survival (OS) measure: Secondary endpoint - Serious Adverse Events (SAE) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St. Elizabeth Cancer Institute status: RECRUITING city: Bratislava zip: 81250 country: Slovakia name: Bela Mrinakova, MD role: CONTACT phone: 00421232249111 email: bela.mrinakova@ousa.sk name: Miriam Hancinova, MD role: CONTACT phone: 00421232249111 email: miriam.hancinova@ousa.sk name: Bela Mrinakova role: PRINCIPAL_INVESTIGATOR name: Miriam Hancinova role: SUB_INVESTIGATOR lat: 48.14816 lon: 17.10674 hasResults: False
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<|newrecord|> nctId: NCT06281132 id: A126_03BE2316 briefTitle: Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic After Oral Administration of CKD-341 and D956 in Healthy Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-22 date: 2024-05-07 date: 2024-05-14 date: 2024-02-28 date: 2024-04-02 name: Chong Kun Dang Pharmaceutical class: INDUSTRY briefSummary: The objective was to evaluate and compare the pharmacokinetic profiles and safety after administration of test drug (CKD-341) and reference drugs (D956) in healthy adults. conditions: Hypertension studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 48 type: ACTUAL name: CKD-341, D956 measure: area under curve(AUC) of CKD-341, D956 measure: Cmax of CKD-341, D956 sex: ALL minimumAge: 19 Years maximumAge: 55 Years stdAges: ADULT facility: Jeonbuk National University Hospital city: Jeonju country: Korea, Republic of lat: 35.82194 lon: 127.14889 hasResults: False
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<|newrecord|> nctId: NCT06281119 id: SII-qHPV/MC-03 briefTitle: Clinical Study to Evaluate SIIPL qHPV Vaccine (CERVAVAC®) in Women Living With HIV Aged 15-25 Years overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-05 date: 2024-02-28 date: 2024-02-28 name: Serum Institute of India Pvt. Ltd. class: INDUSTRY name: Bill and Melinda Gates Foundation briefSummary: Human papillomavirus (HPV) infection is the most common viral infection of the reproductive tract. Up to 80%of the sexually active females and men will be infected with HPV at some point in their lives and some may be repeatedly infected. The main burden of HPV-related disease is due to cervical cancer. Since cervical screening only detects precancerous and cancerous changes after they have occurred, HPV vaccination is primary prevention. People with HIV infection, even when effectively treated with antiretroviral therapy (ARV),are at higher risk of acquiring infection with multiple HPV types and are also known to be predisposed to a higher risk of HPV infection and subsequent CIN lesions. Vaccination of this high-risk group with HPV vaccine is highly beneficial. SIIPL's qHPV vaccine CERVAVAC®, India's first indigenous qHPV vaccine has received marketing authorization in India. The current study is a Phase 3b study to evaluate the immunogenicity and safety of two- and three-dose schedules of SIIPL qHPV vaccine in women living with HIV (WLWH) aged 15-25years. conditions: Human Papillomavirus Infection studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 450 type: ESTIMATED name: Cervavac as three dose regimen name: Cervavac as two dose regimen name: Gardasil as three dose regimen measure: Geometric mean titers of anti HPV 16 and 18 IgG antibodies measure: Immune response (Geometric mean titers) of anti HPV 6 and 11 IgG antibodies measure: Geometric mean titers of anti HPV 6, 11, 16 and 18 IgG antibodies and Pecentage seroconversion measure: Adverse Events measure: Geometric mean titers of anti HPV 6, 11, 16 and 18 IgG antibodies and Pecentage seroconversion measure: Geometric mean titers of anti HPV 6, 11, 16 and 18 IgG antibodies and Pecentage measure: CD4+ cell count, HIV viral load, and HIV clinical staging sex: FEMALE minimumAge: 15 Years maximumAge: 25 Years stdAges: CHILD stdAges: ADULT facility: Centre For Clinical Research, Kemri city: Nairobi zip: 54840-00200 country: Kenya name: Nelly Mugo role: CONTACT phone: +254733629665 email: rwamba@uw.edu lat: -1.28333 lon: 36.81667 facility: Partners in Health and Research Development (Phrd) city: Thika zip: 19865-00202 country: Kenya name: Nelly Mugo role: CONTACT phone: +254733629665 email: rwamba@uw.edu lat: -1.03326 lon: 37.06933 facility: Manhiça Health Research Center - Manhiça Foundation (CISM-FM) city: Manhiça zip: 1929 country: Mozambique name: Tacilta Nhampossa role: CONTACT phone: +258 21 810 181 email: tacilta.nhampossa@manhica.net facility: Clinical HIV Research Unit (CHRU), Helen Joseph Hospital city: Johannesburg zip: 2092 country: South Africa name: Carla Chibwesha role: CONTACT phone: +27 072 744 7899 email: carla_chibwesha@med.unc.edu lat: -26.20227 lon: 28.04363 hasResults: False
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<|newrecord|> nctId: NCT06281106 id: IM011-1118 id: KOFAM 2023-01731 type: OTHER domain: CER-VD briefTitle: TYK2 Inhibition in Paradoxical Psoriasis acronym: TYPP overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-08 date: 2025-08 date: 2024-02-28 date: 2024-02-28 name: Prof Curdin Conrad class: OTHER name: Centre Hospitalier Universitaire Vaudois briefSummary: Paradoxical psoriasis is a side effect of a biological treatment (anti-tumor necrosis factor agent, short called anti-TNF) that is used to treat diseases of the skin, the intestine or the joints. If paradoxical psoriasis occurs, the anti-TNF-treatment often needs to be stopped and so far, no specific treatment for paradoxical psoriasis exists.
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This research project aims to study whether the efficacy of the drug 'Deucravacitinib' 6mg, a tablet taken by mouth once a day is superior compared to taking a placebo in treating paradoxical psoriasis. conditions: Psoriasis studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: During 4 weeks the patients of the 2 arms receive either Deucravacitinib 6mg 1x/day or an identically looking placebo.
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At Week 4, Patients with underlying disease of Crohn's disease, colitis ulcerosa, uveitis will stop the study, to avoid that they are too long without efficient treatment for their underlying disease.
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Patients with underlying disease of psoriasis or psoriatic arthritis will have the possiblity to continue in Part 2, where they all will receive Deucravacitinib 6mg 1x/day, open label for 3 months primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Lab personnel whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 26 type: ESTIMATED name: Deucravacitinib measure: Paradoxical Psoriasis Investigator Global Assessment measure: Paradoxical Psoriasis Body Surface Area measure: Paradoxical Psoriasis palmoplantar Psoriasis Area and Severity Index measure: Paradoxical Psoriasis Scalp Investigator General Assessment measure: Psoriasis Area and Severity Index (PASI) measure: American College of Rheumatology (ACR) Score measure: Nanostring sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Centre hospitalier universitaire vaudois (CHUV) city: Lausanne state: VD zip: 1011 country: Switzerland name: Franziska Stuber, RN role: CONTACT phone: +41 21 3143427 email: franziska.stuber@chuv.ch name: Curdin Conrad, Professor role: PRINCIPAL_INVESTIGATOR lat: 46.516 lon: 6.63282 hasResults: False
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<|newrecord|> nctId: NCT06281093 id: PI2022_843_0089 briefTitle: Radiofrequency Fields in Neonatology: Exposure and Impact on the Nervous System acronym: CHARLINE overallStatus: RECRUITING date: 2024-02-20 date: 2026-09 date: 2026-10 date: 2024-02-28 date: 2024-03-13 name: Centre Hospitalier Universitaire, Amiens class: OTHER name: University Hospital, Brest name: CHU LYON name: University Hospital, Strasbourg, France name: University Hospital, Toulouse briefSummary: Previously, the investigators showed that preterm newborns are exposed chronically to very low radiofrequency levels in average while hospitalized in NICUs. Most of the infants were nevertheless frequently exposed to transient values above 1 V/m. The investigators also showed that an increase in RF exposure is likely to alter the activity of some neurophysiological functions and their regulatory systems in preterm newborns. The investigators hypothesize that above results are extremely specific to the location of the previous study and may be different in other NICU environments.
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This study will aim at quantifying RF levels to which preterm newborns are exposed during their stay in several NICUs spread across the French territory, and assessing its impact on the central and peripheral nervous systems. The first step of this study will be to quantify the precise, continuous and individual levels of daily RF exposure to which each recruited neonate is subjected during his stay in the different NICUs from birth to 1 week postnatal life. Infants' clinical data (medical history, nutrition, morphology...) will also be continually monitored. At 1 week postnatal life, the investigators will investigate cerebral activity (EEG) and autonomic nervous system activity (ECG, heart rate variability). The impact of RF will be evaluated by analyses of the relationship between exposure levels and the various parameters extracted from the neurophysiological investigation phase. conditions: Preterm Newborn studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 200 type: ESTIMATED name: questionary name: Daily continuous recording of radiofrequency exposure levels name: Follow-up of daily infants clinical parameters name: recording of cerebral (EEG) name: autonomic nervous (ECG) activity measure: Variation of the spectral power in the α band (8-12 Hz) of the EEG measure: variation of the spectral power in the delta (δ, 0.5-4 Hz) of the EEG sex: ALL minimumAge: 1 Day maximumAge: 1 Month stdAges: CHILD facility: Amiens University Hospital status: RECRUITING city: Amiens state: Picardie zip: 80054 country: France name: Pierre Tourneux, MD role: CONTACT phone: +33 3 22 66 82 86 email: tourneux.pierre@chu-amiens.fr name: Erwan STÉPHAN-BLANCHARD, Dr role: PRINCIPAL_INVESTIGATOR name: Stéphane DELANAUD, PhD role: SUB_INVESTIGATOR name: Frédéric TELLIEZ, Pr role: SUB_INVESTIGATOR name: Karen CHARDON, Pr role: SUB_INVESTIGATOR name: Brahim SELMAOUI, Dr role: SUB_INVESTIGATOR name: Débora TUKA role: SUB_INVESTIGATOR name: Jean-Michel ROUÉ, Pr role: PRINCIPAL_INVESTIGATOR name: Marine BUTIN, Pr role: PRINCIPAL_INVESTIGATOR name: Pierre KUHN, Pr role: PRINCIPAL_INVESTIGATOR name: Géraldine GASCOIN, Pr role: PRINCIPAL_INVESTIGATOR lat: 49.9 lon: 2.3 hasResults: False
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<|newrecord|> nctId: NCT06281080 id: CRE2023.589-T briefTitle: First-in-Human Trial of a Novel Endoluminal Robotic System for En-Bloc Resection of Bladder Tumours overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-06-30 date: 2025-09-30 date: 2024-02-28 date: 2024-02-28 name: Chinese University of Hong Kong class: OTHER name: Agilis Robotics Limited briefSummary: This is a prospective, single-arm study to evaluate the feasibility and safety of performing transurethral en-bloc resection of bladder tumours using the Zenith robotic system. conditions: Bladder Cancer studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 10 type: ESTIMATED name: En-Bloc Resection of Bladder Tumours measure: Successful en-bloc tumour resection by the robotic system measure: Dissection time and speed measure: Total procedure time measure: Surgeon Console time measure: Presence of detrusor muscle in specimen measure: Resection Margin measure: Intra-operative bladder perforation event measure: Post-operative complications measure: Need of bladder irrigation measure: Residual tumour or upstaging of tumour after second look TURBT sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06281067 id: 271.673 briefTitle: Reassessment of myocardIAL Bridge TOwards PeRsOnalized Medicine acronym: RIALTO PRO overallStatus: RECRUITING date: 2023-12-15 date: 2026-01-01 date: 2026-01-01 date: 2024-02-28 date: 2024-02-28 name: Azienda Ospedaliero Universitaria Maggiore della Carita class: OTHER name: Università degli Studi del Piemonte Orientale "Amedeo Avogadro" briefSummary: The "RIALTO-PRO" study aims to optimize the diagnostic and therapeutic algorithm for myocardial bridge (MB) patients, testing the diagnostic value of a full invasive diagnostic procedure, and, consequently, the prognostic value of a tailored approach. the study objective is to determine the diagnostic and prognostic value of a full-physiology approach strategy versus a standard approach strategy in patients with a MB.
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The "RIALTO PRO" study is a randomized, multicentre, prospective, open-label, superiority trial comparing a personalised versus standard management in patients with MB. Consenting and eligible patients will be randomised 1:1 to either a "full-physiology approach", consisting of a comprehensive diagnostic algorithm aimed at unmasking the main pathophysiological mechanism of myocardial ischemia and consequently a tailored treatment, or a "standard approach", consisting of angiographic evaluation of the tunnelled segment. conditions: Myocardial Bridge studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: NONE count: 500 type: ESTIMATED name: "full-physiology approach" arm name: "standard approach" arm measure: The composite of significant angina and MACE measure: Rate of patients with significant angina (SAQ Angina Summary Score ≤ 70) measure: Incidence of MACE measure: Rate of cardiac death measure: Rate of MI measure: Rate of cardiac hospitalization measure: Rate of TLR sex: ALL minimumAge: 18 Years maximumAge: 75 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Ospedale Generale Regionale F. Miulli status: NOT_YET_RECRUITING city: Acquaviva Delle Fonti country: Italy lat: 40.89704 lon: 16.8433 facility: Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo status: NOT_YET_RECRUITING city: Alessandria country: Italy lat: 44.90924 lon: 8.61007 facility: Ospedale San Donato status: NOT_YET_RECRUITING city: Arezzo country: Italy lat: 43.46276 lon: 11.88068 facility: ASST Papa Giovanni XXIII status: NOT_YET_RECRUITING city: Bergamo country: Italy lat: 45.69601 lon: 9.66721 facility: Ospedale degli Infermi di Biella status: NOT_YET_RECRUITING city: Biella country: Italy lat: 45.56304 lon: 8.05796 facility: Policlinico S. Orsola IRCCS Azienda Ospedaliero Universitaria status: NOT_YET_RECRUITING city: Bologna country: Italy lat: 44.49381 lon: 11.33875 facility: Azienda Ospedaliera di Rilievo Nazionale Sant'Anna e San Sebastiano status: NOT_YET_RECRUITING city: Caserta country: Italy lat: 41.07262 lon: 14.33231 facility: Villa Maria Cecilia Hospital status: NOT_YET_RECRUITING city: Cotignola country: Italy lat: 44.38572 lon: 11.93852 facility: Azienda Ospedaliero Universitaria di Ferrara status: NOT_YET_RECRUITING city: Ferrara country: Italy lat: 44.83804 lon: 11.62057 facility: Azienda Ospedaliero Universitaria Careggi status: NOT_YET_RECRUITING city: Firenze country: Italy lat: 43.77925 lon: 11.24626 facility: Azienda Ospedaliera Universitaria Policlinico San Martino status: NOT_YET_RECRUITING city: Genova country: Italy lat: 44.40478 lon: 8.94438 facility: Ospedale Della Misericordia status: NOT_YET_RECRUITING city: Grosseto country: Italy lat: 42.76296 lon: 11.10941 facility: Centro Cardiologico Monzino IRCCS status: NOT_YET_RECRUITING city: Milano country: Italy lat: 45.46427 lon: 9.18951 facility: IRCCS Ospedale Galeazzi status: NOT_YET_RECRUITING city: Milano country: Italy lat: 45.46427 lon: 9.18951 facility: Fondazione IRCCS San Gerardo dei Tintori status: NOT_YET_RECRUITING city: Monza country: Italy lat: 45.58005 lon: 9.27246 facility: AOU Maggiore della Carità status: RECRUITING city: Novara zip: 28100 country: Italy name: Domenico D'Amario, Prof role: CONTACT phone: 0039 0321 3733141 email: domenico.damario@uniupo.it name: Domenico D'Amario, Prof role: PRINCIPAL_INVESTIGATOR name: Giuseppe Patti, Prof role: PRINCIPAL_INVESTIGATOR lat: 45.44694 lon: 8.62118 facility: Azienda Ospedaliero Universitaria di Parma status: NOT_YET_RECRUITING city: Parma country: Italy lat: 44.79935 lon: 10.32618 facility: Azienda Ospedaliera di Perugia status: NOT_YET_RECRUITING city: Perugia country: Italy lat: 43.1122 lon: 12.38878 facility: Azienda Ospedaliero Universitaria Pisana status: NOT_YET_RECRUITING city: Pisa country: Italy lat: 43.70853 lon: 10.4036 facility: Ospedale San Jacopo status: NOT_YET_RECRUITING city: Pistoia country: Italy lat: 43.93064 lon: 10.92365 facility: Ospedali Riuniti di Rivoli status: NOT_YET_RECRUITING city: Rivoli country: Italy lat: 45.07073 lon: 7.51465 facility: Aurelia Hospital status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Azienda Ospedaliera San Camillo-Forlanini status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Azienda Ospedaliero Universitaria Sant'Andrea status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS status: RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Sandro Pertini status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Santo Spirito status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Policlinico Universitario Tor Vergata Fondazione PTV status: NOT_YET_RECRUITING city: Roma country: Italy lat: 41.89193 lon: 12.51133 facility: Ospedale Civile Santissima Annunziata status: NOT_YET_RECRUITING city: Sassari country: Italy lat: 40.72586 lon: 8.55552 facility: Azienda Sanitaria Provinciale di Siracusa status: NOT_YET_RECRUITING city: Siracusa country: Italy lat: 37.08415 lon: 15.27628 facility: Azienda Ospedaliera Ordine Mauriziano status: NOT_YET_RECRUITING city: Torino country: Italy lat: 45.07049 lon: 7.68682 facility: Azienda Ospedaliero Universitaria Città Della Salute E Scienza status: NOT_YET_RECRUITING city: Torino country: Italy lat: 45.07049 lon: 7.68682 facility: Presidio Ospedaliero Sant'Andrea status: NOT_YET_RECRUITING city: Vercelli country: Italy lat: 45.32163 lon: 8.41989 facility: Azienda Ospedaliera Universitaria Integrata, Ospedale Borgo Trento status: NOT_YET_RECRUITING city: Verona country: Italy lat: 45.4299 lon: 10.98444 hasResults: False
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<|newrecord|> nctId: NCT06281054 id: SMC2023-12-027 briefTitle: Acute Myocardial Infarction in Cancer Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2002-01-01 date: 2021-12-31 date: 2024-12-31 date: 2024-02-28 date: 2024-02-28 name: Samsung Medical Center class: OTHER name: Chonnam National University briefSummary: Using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction that can improve long-term prognosis. conditions: Acute Myocardial Infarction conditions: Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 4500000 type: ESTIMATED name: Revascularization measure: All-cause death measure: Myocardial infarction measure: Revascularization measure: Hospitalization for heart failure measure: Stroke measure: Clinically relevant bleeding sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Chonnam National University Hospital, Chonnam National University Medical School city: Gwangju country: Korea, Republic of lat: 35.15472 lon: 126.91556 hasResults: False
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<|newrecord|> nctId: NCT06281041 id: NHIS20240220 briefTitle: Nationwide Cohort Study of Antiplatelet Agents as Primary Prevention acronym: NHIS overallStatus: ACTIVE_NOT_RECRUITING date: 2013-01-01 date: 2020-12-31 date: 2024-12-31 date: 2024-02-28 date: 2024-02-28 name: Samsung Medical Center class: OTHER name: Chonnam National University briefSummary: There is no specific recommendation regarding pharmacologic treatment as primary prevention for patients with intermediate coronary artery stenosis whose revascularization was deferred based on negative fractional flow reserve (FFR).
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Current nationwide cohort study conducted using Korean National Health Insurance Service database evaluated the safety and efficacy of antiplatelet therapy in patients with intermediate coronary artery stenosis with deferred revascularization based on negative FFR (FFR\>0.80). conditions: Coronary Artery Disease conditions: Coronary Artery Stenosis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 4657 type: ACTUAL name: Antiplatelet Agents measure: Major adverse cardiac and cerebrovascular events measure: Gastrointestinal bleeding measure: All-cause death measure: Myocardial infarction measure: Unplanned revascularization measure: Stroke measure: Major bleeding measure: Gastrointestinal bleeding necessitated hospitalization without documented transfusion measure: Intracranial hemorrhage sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Chonnam National University Medical School city: Gwangju country: Korea, Republic of lat: 35.15472 lon: 126.91556 hasResults: False
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<|newrecord|> nctId: NCT06281028 id: 2023-A02280-45 briefTitle: SOLACEA-H in Heparin-sparing Haemodialysis acronym: SOLHEPA overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-09 date: 2025-09 date: 2024-02-28 date: 2024-02-28 name: GCS Ramsay Santé pour l'Enseignement et la Recherche class: OTHER briefSummary: The aim of the study is to evaluate the efficacy of the SOLACEA-H dialyser, particularly in patients at high risk of haemorrhage, during post-dilution haemodiafiltration sessions with complete or partial heparin sparing. It will be compared with another dialyser (HYDROLINK-NVU) conditions: Dialysis Membrane Reaction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Prospective, multicenter, randomized primaryPurpose: TREATMENT masking: NONE count: 19 type: ESTIMATED name: SOLACEA-H/HYDROLINK-NVU name: HYDROLINK-NVU/SOLACEA-H measure: SOLACEA-H vs HYDROLINK-NVU efficacy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Hôpital Privé La Louvière city: Lille zip: 59800 country: France name: Maxime HOFFMANN, MD role: CONTACT phone: 6 86 70 91 23 phoneExt: +33 email: maxime.hoffmann@gmail.com lat: 50.63297 lon: 3.05858 hasResults: False
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<|newrecord|> nctId: NCT06281015 id: 2023PI095-407 briefTitle: Artificial Intelligence and Bone Tomoscintigraphies Achieved With CZT Camera acronym: IATOS overallStatus: COMPLETED date: 2023-08-30 date: 2023-09-10 date: 2023-10-30 date: 2024-02-28 date: 2024-02-28 name: Central Hospital, Nancy, France class: OTHER briefSummary: This study aimed to determine whether the whole-body bone Single Photon Emission Computed Tomography (SPECT) recording times of around 10 minutes, routinely provided by a high-sensitivity 360 degrees cadmium and zinc telluride (CZT) camera, can be further reduced by a deep learning noise reduction (DLNR) algorithm. conditions: Bone Lesion studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 19 type: ACTUAL name: Whole-body bone single photon emission tomography (SPECT) for detection or follow-up of bone metastasis measure: Assess a dedicated deep learning noise reduction algorithm sex: ALL minimumAge: 18 Years maximumAge: 95 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHRU Nancy city: Vandoeuvre les Nancy cedex zip: 54511 country: France lat: 48.65 lon: 6.18333 hasResults: False
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<|newrecord|> nctId: NCT06281002 id: FDASU-RecIM112323 briefTitle: Trueness of Full Arch Scans and Generated Digital Implant Models overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2024-12 date: 2024-02-28 date: 2024-03-06 name: Ain Shams University class: OTHER briefSummary: The goal of this clinical trial study is to evaluate the accuracy of the full digital workflow for four-implant, screw-retained mandibular hybrid prostheses in patients with completely edentulous mandible. conditions: Denture conditions: Complete Edentulism studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 9 type: ESTIMATED name: conventional impression stone casts digitization name: digital scanning with coupled scanning aiding device name: Digital Implant Model assessment of accuracy measure: Trueness of full arch digital scans when additional geometric scanning aids are coupled with the scan bodies. measure: Trueness of the generated 3D-printed digital implant models. sex: ALL minimumAge: 45 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
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<|newrecord|> nctId: NCT06280989 id: P.T.REC/012/004768 briefTitle: Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-07 date: 2024-08 date: 2024-02-28 date: 2024-02-29 name: Cairo University class: OTHER briefSummary: the aim of this study is to investigate the efficacy of kinesio taping versus myofascial release technique on menstrual low back pain in young females conditions: Low Back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: kinesio taping and myofascial release technique primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: kinesio taping name: myofascial release technique measure: pain intensity measure: pain pressure threshold measure: severity of dysmenorrhea measure: Assess the function disability level sex: FEMALE minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Hala mohamed ahmed morsy city: Giza zip: 12511 country: Egypt name: hala ma morsy, Bachelor role: CONTACT phone: 00201028616865 email: halamohamed8.11.2018@gmail.com lat: 30.00808 lon: 31.21093 hasResults: False
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