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<|newrecord|> nctId: NCT06280976 id: 23.0001 briefTitle: Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP) acronym: ARTCAP overallStatus: RECRUITING date: 2024-03-01 date: 2029-01-31 date: 2029-01-31 date: 2024-02-28 date: 2024-04-25 name: University of Louisville class: OTHER briefSummary: The purpose of this study is to evaluate the role of coronary CT angiogram (CCTA) as a superior guide for the assessment of coronary artery plaque and guiding treatment decisions. The investigators also assess the impact of preventive cardiovascular drugs on the plaque to improve patient outcomes. Participants aged 18-80 years, at intermediate or high-risk for coronary artery disease, with non-obstructive plaque on initial CCTA, will be enrolled in this study. They will be randomized into Standard of Care (SOC) vs. Aggressive Therapy (AT) groups. Both groups will undergo dietary and lifestyle interventions. Follow-up will consist of blood tests and clinic visits at baseline, 9 months, and 18 months. The second CCTA will be performed at 18 months to assess the change in plaque burden, characteristics, ischemia and pericoronary/epicardial fat. conditions: Coronary Artery Disease conditions: Atherosclerosis conditions: Heart Attack studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: PROBE design: Prospective Randomized Open Label Blinded End-point primaryPurpose: TREATMENT masking: NONE count: 200 type: ESTIMATED name: Statin name: Aspirin tablet name: Nexlizet name: LEQVIO name: Vascepa name: Jardiance name: Colchicine measure: Plaque quantification measure: Characterization of plaque to evaluate for high-risk features - positive remodeling measure: Quantification of stenosis measure: Quantification of pericoronary fat attenuation. measure: Characterization of plaque to evaluate for high-risk features - low CT attenuation measure: Characterization of plaque to evaluate for high-risk features - napkin-ring sign measure: Quantification of epicardial fat attenuation. measure: Major adverse cardiac and cardiovascular events (MACCE) measure: Polygenic risk score (PRS) measure: Next generation sequencing (NGS) measure: Change in Lipoprotein (a) measure: Change in myeloperoxidase (MPO) activity measure: Change in trimethylamine-N-oxide (TMAO) levels measure: Change in lipoprotein-associated phospholipase A2 (Lp-PLA2) levels measure: Change in interleukin-6 (IL-6) levels measure: Change in high sensitivity C-creative protein (HS-CRP) levels measure: Buffy coat for chromatin immunoprecipitation (ChIP) measure: Change in high sensitivity Troponin (HS-Tn) measure: Change in natriuretic peptide (BNP, NT-pro BNP measure: Change in levels of open reading frame 1 protein (ORF1p) sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Louisville School of Medicine, Division of Cardiovascular Diseases status: RECRUITING city: Louisville state: Kentucky zip: 40202 country: United States name: Dinesh Kalra, MD role: CONTACT phone: 502-588-7010 email: diniesh.kalra@louisville.edu name: Muhammad Umer, MD role: CONTACT phone: 502-588-7010 email: muhammad.umer.1@louisville.edu lat: 38.25424 lon: -85.75941 hasResults: False
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<|newrecord|> nctId: NCT06280963 id: 012/005532 briefTitle: Posterior Innominate Mobilization Versus Muscle Energy Technique on Lumbopelvic Angles in Sacroiliac Joint Dysfunction acronym: MET overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-01 date: 2024-08-03 date: 2024-02-28 date: 2024-02-28 name: Mahmoud Yousry Rashwan Hefny class: OTHER briefSummary: the goal of this clinical trial study is to compare between posterior innominate mobilization and muscle energy techniqueon lumbopelvic angles in sacroiliac joint dysfunction patients.
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the main questions they aim to answer are
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1. are there statistical significant effects of posterior innominate mobilization versus muscle energy technique on lumbopelvic angles in sacroiliac joint dysfunction patients ?
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2. are there statistical significant effects of posterior innominate mobilization versus muscle energy technique on pain intensity level in sacroiliac joint dysfunction patients ?
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* purpose of the study is to measure the effect of muscle energy technique versus posterior innominate mobilization on lumbopelvic angles in sacroiliac joint dysfunction conditions: Sacroiliac Joint Dysfunction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: FACTORIAL interventionModelDescription: group one will receive muscle energy technique group two will receive posterior innominate mobilization group three will receive conventional treatment ( TENS , US , stertching exercises and strenghening exercises ) primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 60 type: ESTIMATED name: muscle energy technique name: posterior innominate mobilization name: conventional treatment measure: lumbopelvic angles measure: pain intensity sex: ALL minimumAge: 25 Years maximumAge: 45 Years stdAges: ADULT facility: Faculty of Physical Therapy status: RECRUITING city: Dokki state: Giza zip: 12612 country: Egypt name: Haytham M Elhafez, PhD role: CONTACT phone: +201001909630 email: elhafez@yahoo.com lat: 30.03823 lon: 31.2113 hasResults: False
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<|newrecord|> nctId: NCT06280950 id: DAIT CTOT-43 briefTitle: Expanding Liver Transplant Immunosuppression Minimization Via Everolimus acronym: ELIMINATE overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2027-06-01 date: 2029-06-01 date: 2024-02-28 date: 2024-02-28 name: National Institute of Allergy and Infectious Diseases (NIAID) class: NIH briefSummary: This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function. Two hundred - seventy (270) subjects will be randomized 2:1 into one of two groups between 2-3 months post-transplant. Seventy participants will be placed into an observational group and will remain on their current post-transplant medications. The duration of the study from time of enrollment is 18-20 months. conditions: Liver Transplant studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 340 type: ESTIMATED name: Everolimus name: Tacrolimus (continued reduction) name: Tacrolimus (maintain 50% reduction) name: Everolimus measure: Percent change in estimated glomerular filtration rate (eGFR) by CKD-EPI 2021 equation. Between Cohorts INT-1 and INT-2 measure: Proportion of subjects with treated Biopsy Proven Acute Rejection (tBPAR) per local pathology. Between cohorts INT-1 and INT-2 measure: Percent change in Estimated Glomerular Filtration Rate (eGFR) in Renal function measure: Percentage of subjects with treated Biopsy Proven Acute Rejection (tBPAR) in Liver Function measure: Changes in liver graft function: Total bilirubin measure: Changes in liver graft function: Direct bilirubin measure: Changes in liver graft function: Alanine Aminotransaminase (ALT) measure: Changes in liver graft function: Aspartate Aminotransferase (AST) measure: Changes in liver graft function: Alkaline Phosphatase measure: Time to graft failure in liver function defined as relisting for transplantation, re-transplantation itself or death with failed graft measure: Time to all-cause mortality measure: Proportion of subjects experiencing a Major Adverse Cardiac Event (MACE) measure: Proportion of subjects experiencing infection requiring hospitalization measure: Proportion of subjects experiencing any malignancy measure: Proportion of subjects developing severe Estimated Glomerular Filtration Rate (eGFR) deterioration >40 percent from baseline using the CKD-EPI 2021 equation measure: Proportion of subjects developing any major immunosuppressive therapy complications measure: Proportion of subjects developing new onset peripheral edema measure: Proportion of subjects developing new onset cytopenia deemed WBC <3.0x10^9 /L, Hb <8.0 g/dL, or platelets <50 x 10^9/L. measure: Proportion of subjects developing new onset oral/gastrointestinal ulcerations measure: Proportion of subjects developing new onset gastrointestinal symptoms (nausea, vomiting, abdominal pain, or diarrhea) related to everolimus therapy. measure: Proportion of subjects developing new onset pneumonitis measure: Proportion of subjects developing new onset hepatic artery thrombosis measure: Proportion of subjects developing other adverse events deemed measure: Proportion of subjects developing any adverse events related to everolimus therapy sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Mayo Clinic Hospital Arizona (Site #: 71144) city: Phoenix state: Arizona zip: 85054 country: United States name: Hugo Vargas, MD role: PRINCIPAL_INVESTIGATOR lat: 33.44838 lon: -112.07404 facility: University of California, San Francisco (Site #: 71108) city: San Francisco state: California zip: 94143 country: United States name: Joanna Kwan role: CONTACT phone: 415-476-2574 email: joanne.kwan@ucsf.edu name: Sandy Feng, MD role: PRINCIPAL_INVESTIGATOR lat: 37.77493 lon: -122.41942 facility: Northwestern University (Site #: 71110) city: Chicago state: Illinois zip: 60611 country: United States name: Dania Jahangir role: CONTACT email: dania.jahangir@northwestern.edu name: Justin Boike, MD role: PRINCIPAL_INVESTIGATOR lat: 41.85003 lon: -87.65005 facility: Icahn School of Medicine at Mount Sinai (Site #: 71115) city: New York state: New York zip: 10029 country: United States name: Bharathi Ramesh role: CONTACT email: Bharathi.ramesh@mountsinai.org name: Thomas Schiano, MD role: PRINCIPAL_INVESTIGATOR lat: 40.71427 lon: -74.00597 facility: Duke University Medical Center (Site #: 71139) city: Durham state: North Carolina zip: 27710 country: United States name: Linda Perry role: CONTACT email: linda.perry@duke.edu name: Carl Berg, MD role: PRINCIPAL_INVESTIGATOR lat: 35.99403 lon: -78.89862 facility: University of Pennsylvania (Site #: 71111) city: Philadelphia state: Pennsylvania zip: 19104 country: United States name: Lexi Tumblety role: CONTACT phone: 267-441-1800 email: lexi.tumblety@pennmedicine.upenn.edu name: Abraham Shaked, MD role: PRINCIPAL_INVESTIGATOR lat: 39.95233 lon: -75.16379 facility: University of Pittsburgh Medical Center (Site #: 71162) city: Pittsburgh state: Pennsylvania zip: 15260 country: United States name: Lois Kipling role: CONTACT email: kniplingle@upmc.edu name: Scott Biggins, MD role: PRINCIPAL_INVESTIGATOR lat: 40.44062 lon: -79.99589 facility: Baylor Medical Center (Site #: 71153) city: Dallas state: Texas zip: 75246 country: United States name: Angela Roy role: CONTACT email: angela.roy@baylorhealth.edu name: Sumeet Asrani, MD role: PRINCIPAL_INVESTIGATOR lat: 32.78306 lon: -96.80667 hasResults: False
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<|newrecord|> nctId: NCT06280937 id: BEUFTR-2 briefTitle: Short Term Effect of Wearing a Tie overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2024-10-01 date: 2024-02-28 date: 2024-02-28 name: Bitlis Eren University class: OTHER briefSummary: The goal of this randomized controlled study is to assess the short term effect of wearing a ties on musculoskeletal system. In this scope viscoelastic properties and the mechanosensitivity of the muscles, and cervical range of motion will be measured. In addition to these measurements activity limitation due to wearing a tie and trunk mobility will be assessed. conditions: Musculoskeletal Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Control group will go on their routine daily activities. Study group will wear a tie during one office working day. primaryPurpose: PREVENTION masking: SINGLE maskingDescription: Interventions and assessment will be performed by separate researchers. whoMasked: OUTCOMES_ASSESSOR count: 54 type: ESTIMATED name: Wearing a tie measure: The Change in the Viscoelastic Properties of the Muscles measure: The Change in the Pressure Pain Threshold of the Spine and Upper Trapezius measure: Cervical Range of Motion measure: Activity Limitation measure: Global Rating of Change measure: Trunk Forward Bending Mobility measure: Trunk Lateral Bending Mobility measure: Neck Circumference sex: MALE minimumAge: 18 Years maximumAge: 25 Years stdAges: ADULT facility: Bitlis Eren University city: Bitlis state: Merkez zip: 13000 country: Turkey lat: 38.40115 lon: 42.10784 hasResults: False
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<|newrecord|> nctId: NCT06280924 id: HREBA.CC-23-0220 briefTitle: Prehab Prior to Stem Cell Transplantation in Multiple Myeloma acronym: MOTIVATE overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-12-31 date: 2026-06-30 date: 2024-02-28 date: 2024-02-28 name: University of Alberta class: OTHER briefSummary: The primary purpose of this study is to see if individuals with Multiple Myeloma are able and interested in taking part in a tailored exercise program while undergoing their chemotherapy prior to a stem cell transplant. We also hope to learn if this type of program, along with a flexible delivery format (in-person and virtual), helps in maintaining or improving physical fitness, muscle mass and strength, and quality of life during chemotherapy. conditions: Multiple Myeloma conditions: Exercise conditions: Prehabilitation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled trial primaryPurpose: SUPPORTIVE_CARE masking: SINGLE maskingDescription: An independent assessor will conduct the post-intervention assessment. The independent assessor will be blinded to group assignment. whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Supported Exercise name: Standard Care measure: Study completion rate measure: Recruitment rate measure: Attendance rate measure: Edmonton Symptom Assessment System measure: Functional Assessment of Cancer Therapy Multiple Myeloma measure: Functional Assessment of Cancer Therapy: Fatigue Subscale (13-item) measure: Body weight measure: Body height measure: Grip Strength measure: Calf muscle size measure: Thigh muscle thickness measure: Short Physical Performance Battery measure: Six-minute walk test measure: One leg stance balance measure: Shoulder flexion range of motion measure: Sit and reach test sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of Alberta/ Cross Cancer Institute city: Edmonton state: Alberta zip: T6G 2G4 country: Canada lat: 53.55014 lon: -113.46871 hasResults: False
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<|newrecord|> nctId: NCT06280911 id: 098 briefTitle: The Effect of Consumption of Date Fruit and Nipple Stimulation in Late Pregnancy overallStatus: COMPLETED date: 2013-10-10 date: 2014-06-30 date: 2017-12-30 date: 2024-02-28 date: 2024-03-04 name: Selcuk University class: OTHER briefSummary: The study was conducted to determine the effect of consumption of date fruit and nipple stimulation on labor.
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The samples were applied to pregnant women satisfying the research criteria in a state hospital in Istanbul between October 2013 and June 2014. conditions: Augmentation conditions: Induction conditions: Labor conditions: Stimulation, Self studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study was designed to be randomly controlled. primaryPurpose: SUPPORTIVE_CARE masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 198 type: ACTUAL name: Date Fruit group name: Nipple group measure: The spontaneous onset of labor measure: Induction and augmentation of labor measure: Mode of delivery sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Zeynep Kamil Women's and Children's Diseases Training and Research Hospital city: Istanbul country: Turkey lat: 41.01384 lon: 28.94966 hasResults: False
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<|newrecord|> nctId: NCT06280898 id: KC22RISI0395 briefTitle: Perioperative Factors and Early Postoperative Kidney Graft Function Recovery overallStatus: COMPLETED date: 2020-05-01 date: 2022-03-14 date: 2022-03-14 date: 2024-02-28 date: 2024-02-29 name: Seoul St. Mary's Hospital class: OTHER briefSummary: Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE), or Kidney Disease: Improving Global Outcomes (KDIGO) I would like to divide it according to the definition. After testing the normal distribution of patients, donors, grafts, types of immunosuppressants, surgery/anesthesia factors, and blood test findings between the two groups through the Shapiro-Wilk test, continuous data was tested using the student t-test or Mann-Whitney U test. Sizes are compared using , and categorical data is compared with proportions using the χ2 test or Fisher's exact test. Analysis of factors related to acute kidney injury will be performed through univariate and multivariate logistic regression analysis. conditions: Heart Injuries conditions: Kidney Transplant; Complications studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 539 type: ACTUAL name: Remote ischemic conditioning measure: Troponin I measure: Troponin T measure: QTc interval sex: ALL minimumAge: 19 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Seoul St. Mary's hospital city: Seoul zip: 06591 country: Korea, Republic of lat: 37.566 lon: 126.9784 hasResults: False
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<|newrecord|> nctId: NCT06280885 id: FIERCE briefTitle: A Flexible Individualized ExeRcise Programme for Cancer Patients During ChEmotherapy acronym: FIERCE overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-09-01 date: 2026-03-31 date: 2024-02-28 date: 2024-02-28 name: University of Dublin, Trinity College class: OTHER name: St. James's Hospital, Ireland briefSummary: The primary aim of this study is to measure the feasibility of delivering a co-designed exercise programme for patients with cancer receiving chemotherapy treatment. conditions: Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Feasibility randomised controlled trial using a 2:1 randomisation primaryPurpose: SUPPORTIVE_CARE masking: NONE maskingDescription: Not indicated for this feasibility study. count: 50 type: ESTIMATED name: Exercise name: Health Behaviour Change (Pedometer) measure: Feasibility: Recruitment rates measure: Feasibility: Adherence rates measure: Feasibility: Attendance rates measure: Feasibility: Retention Rates measure: Feasibility: Reason for drop0out measure: Cardiorespiratory Fitness measure: Muscular Strength measure: Body Mass Index measure: Mid-arm circumference measure: Waist Circumference measure: Bioimpedance Analysis measure: Health Related Quality of Life measure: Fatigue sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: St James's Hospital city: Dublin zip: 8 country: Ireland lat: 53.33306 lon: -6.24889 hasResults: False
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<|newrecord|> nctId: NCT06280872 id: P2023/Neonat/PhyCordPrem briefTitle: Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns acronym: PhyCordPrem overallStatus: RECRUITING date: 2024-02-19 date: 2026-01 date: 2026-07 date: 2024-02-28 date: 2024-03-05 name: Queen Fabiola Children's University Hospital class: OTHER name: The Belgian Kids Fund name: Fonds IRIS-Recherche name: Ars Statistica briefSummary: Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid. After vaginal delivery, the umbilical cord is clamped and cut after a delay that allows some of the blood in the umbilical cord and placenta to flow back into the baby. Meanwhile, as the baby breathes for the first time, the lungs fill with air and more fluid is pushed out. However, it does not always work out that way.
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A baby born prematurely may have breathing problems because of extra fluid staying in the lungs related to the immaturity of the lung structure. Thus, the baby must breathe quicker and harder to get enough oxygen enter into the lungs. The newborn is separated from the mother to provide emergency respiratory support. Although the baby is usually getting better within one or two days, the treatment requires close monitoring, breathing help, and nutritional help as the baby is too tired to suck and swallow milk. Sometimes, the baby cannot recover well and show greater trouble breathing needing intensive care. This further separates the mother and her baby. A possible mean to help the baby to adapt better after a premature birth while staying close to the mother is to delay cord clamping when efficient breathing is established, either spontaneously or after receiving breathing help at birth. In this study, we intend to test this procedure in moderate or late preterm infants and see whether the technique helps the baby to better adapt after birth and to better initiate a deep bond with the mother. conditions: Premature Birth conditions: Respiratory Distress Syndrome in Premature Infant conditions: Sepsis conditions: Intraventricular Hemorrhage of Prematurity conditions: Bronchodysplasia conditions: Jaundice studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 180 type: ESTIMATED name: Physiological Based Cord Clamping name: Differed Cord Clamping measure: Duration of non-invasive or invasive respiratory support. measure: Rate of neonatal mortality measure: Rate of neonatal resuscitation measure: Rate of neonatal respiratory morbidity measure: Number of admission to the NICU or special care baby unit measure: Length of hospitalization measure: Gestational age corrected at discharge measure: Changes in physiological variables during neonatal transition measure: Early neonatal parameters measure: Hemoglobin level measure: Bilirubin level measure: Occurrence of Neonatal adverse events measure: Biological markers of oxidative stress measure: Maternal perioperative parameters measure: Maternal postoperative hemoglobin level measure: Number of maternal adverse events measure: Maternal-infant bonding measure: Maternal-infant bonding measure: Maternal-infant bonding measure: Rate of Maternal-infant bonding measure: Rate of Maternal-infant bonding measure: Rate of Maternal-infant bonding measure: Maternal-infant bonding measure: Parental satisfaction survey measure: Child development assessment measure: Success of PBCC sex: ALL minimumAge: 32 Weeks maximumAge: 36 Weeks stdAges: CHILD facility: CHU Brugmann status: RECRUITING city: Brussels zip: 1020 country: Belgium name: Andrew CARLIN role: CONTACT phone: +3224773295 email: andrew.carlin@chu-brugmann.be name: Andrew CARLIN, MD role: PRINCIPAL_INVESTIGATOR lat: 50.85045 lon: 4.34878 facility: Hôpital Universitaire Des Enfants Reine Fabiola status: RECRUITING city: Brussels zip: 1020 country: Belgium name: Anna AMORUSO, MD role: CONTACT phone: +3224773250 email: anna.amoruso@hubruxelles.be name: Anna AMORUSO role: PRINCIPAL_INVESTIGATOR lat: 50.85045 lon: 4.34878 hasResults: False
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<|newrecord|> nctId: NCT06280859 id: 18784 briefTitle: Hoosier Sport: Developing and Implementing a Sustainable Campus-Community Partnership in Rural Indiana overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-20 date: 2024-05-30 date: 2024-06-10 date: 2024-02-28 date: 2024-03-15 name: Indiana University class: OTHER name: United States Department of Agriculture (USDA) briefSummary: The clinical trial aims to develop and pilot test a multilevel physical activity (PA) intervention called the Hoosier Sport program. The study follows a participatory co-design protocol involving youth, parents, and community leaders to provide direct input into the intervention's design. The ultimate goal is to contribute to health equity in the community by promoting sustainable physical activity. Hoosier Sport involves delivering enhanced physical education classes, teaching about nutrition and exercise, as well as developing leadership skills in middle school rural students.The intervention will last for 8-weeks with PE classes occur twice a week. Additionally, Hoosier Sport will create more opportunities for students to be active at school (e.g., in home room) through providing virtual classes and other activities. conditions: Cardiovascular Diseases conditions: Sedentary Behavior studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Students enrolled in physical education (PE) class will be eligible to enroll in the study, and serve as the intervention group. Those not enrolled in PE that semester will be recruited as the control group. primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 34 type: ACTUAL name: Hoosier Sport measure: Feasibility of Intervention Measure (FIM) measure: Acceptability of Intervention Measure (IAM) measure: Intervention Appropriateness Measure (AIM) measure: Daily Steps of Participants measure: Daily Moderate to Vigorous Physical Activity of Participants measure: Heart Rate of Participants measure: Blood Pressure of Participants measure: Basic Psychological Needs of Participants in Intervention Environment measure: Physical Literacy of Participants measure: Cardiovascular Fitness Levels of Participants measure: Muscular Endurance Levels of Participants measure: Self-Reported Weekly Moderate to Vigorous Physical Activity of Participants measure: Nutrition Knowledge of Participants measure: Policy, Systems, and Environmental Factors Influencing Participant Physical Activity and Nutrition Behavior. sex: ALL minimumAge: 9 Years maximumAge: 15 Years stdAges: CHILD facility: Indiana University city: Bloomington state: Indiana zip: 47405 country: United States lat: 39.16533 lon: -86.52639 hasResults: False
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<|newrecord|> nctId: NCT06280846 id: P.T.REC/012/004878 briefTitle: High-intensity Versus Low-intensity Laser Acupuncture in Chronic, Non-specific Low Back Pain overallStatus: RECRUITING date: 2024-03-15 date: 2024-10-30 date: 2024-10-30 date: 2024-02-28 date: 2024-04-26 name: Cairo University class: OTHER name: King Khalid University briefSummary: The purpose of this study is to investigate the efficacy of high-intensity laser acupuncture versus low intensity laser acupuncture on peak torque of trunk extensors, fatigue of trunk extensors, back pain, ROM and function in patients with chronic nonspecific low back pain (CNLBP). conditions: Chronic Nonspecific Low-back Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: high-intensity laser acupuncture, low-intensity laser acupuncture and exercise therapy program primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: random generator whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: high-intensity laser acupuncture and Exercise therapy program name: low-intensity laser acupuncture and Exercise therapy program name: Sham laser acupuncture measure: peak torque measure: peak torque measure: Fatigue measure: Fatigue measure: Pain Intensity measure: Pain Intensity measure: lumbar flexion ROM assessment measure: lumbar flexion ROM assessment measure: Disability measure: Disability sex: ALL minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Doaa Ayoub Elimy status: RECRUITING city: Giza zip: 11251 country: Egypt name: Doaa A Elimy, lecturer role: CONTACT phone: 00201066474654 email: do3aayoub25@gmail.com lat: 30.00808 lon: 31.21093 hasResults: False
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<|newrecord|> nctId: NCT06280833 id: 10001884 id: 001884-HG briefTitle: Care Choreographies and the Making of the Psychosocial in Genetic Counseling overallStatus: RECRUITING date: 2024-05-01 date: 2024-10-01 date: 2024-10-01 date: 2024-02-28 date: 2024-04-26 name: National Human Genome Research Institute (NHGRI) class: NIH briefSummary: Background:
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Genetic counselors play a new and evolving role in medical care. Recent advances in genetic testing are changing many health care treatments, and genetic counselors play a key role in teaching people how their genes may affect both health and treatments. Genetic counselors may also help guide people through complex talks about their treatment risks; their chances for recovery; and their social and emotional health and wellbeing. Researchers want to learn more about the role genetic counselors play in health care.
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Objective:
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To observe how genetic counselors at NIH manage the social and psychological aspects of patient care.
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Eligibility:
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Genetic counselors who work at NIH. People aged 18 years or older who are scheduled to meet with one of these counselors are also needed.
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Design:
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An investigator will sit in on the session between the counselor and the participant. The investigator will take notes. The session will not be recorded. The investigator will leave at any point if asked.
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The investigator will focus on talk about social and psychological care. That person will also listen to talk about risk; diagnosis; odds of recovery; and hope, grief, and loss. That person will note strategies that help the participant manage their emotions and how they perceive their risks.
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Counselors may later have a 1-hour interview with the investigator. They will answer questions about their experiences as a care provider at NIH.
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Participants will have only 1 session with the investigator. Counselors may have 4 to 10 sessions with an investigator over 8 months. conditions: Genetic Counselor studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 250 type: ESTIMATED measure: Care sex: ALL minimumAge: 18 Years maximumAge: 115 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Human Genome Research Institute (NHGRI) status: RECRUITING city: Bethesda state: Maryland zip: 20892 country: United States name: Sara Hull, Ph.D. role: CONTACT phone: 301-435-8712 email: shull@nhgri.nih.gov lat: 38.98067 lon: -77.10026 hasResults: False
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<|newrecord|> nctId: NCT06280820 id: 10001889 id: 001889-H briefTitle: Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-04-30 date: 2034-04-30 date: 2024-02-28 date: 2024-04-26 name: National Heart, Lung, and Blood Institute (NHLBI) class: NIH briefSummary: Background:
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More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year. Treatments have improved in recent years, but researchers want to understand more about how HF develops. To do this, they need to compare blood and other samples from many people with HF.
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Objective:
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To collect blood and other samples from people with HF. These samples will be used to identify and study proteins and other factors that may lead to decreased heart function over time.
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Eligibility:
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People aged 18 years and older with heart failure.
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Design:
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Participants will be asked to join the study based on a review of their medical records.
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They will have 1 study visit. They will provide a blood sample: About 3 tablespoons will be collected from a needle inserted into a vein.
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Other tests are optional: Participants may provide urine and stool samples. They may have a cotton swab rubbed on the inside of the mouth to collect DNA.
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Participants may also take 3 questionnaires. They will answer questions about dietary, social, and other factors that affect their health. Participants will receive compensation.
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Researchers will follow the participants health by monitoring their medical records for up to 5 years. conditions: Heart Failure studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 2000 type: ESTIMATED measure: To study the association between multi-omics signatures with all-cause mortality measure: Clinical phenotypes defined by:Ejection Fraction (>=50 vs. < 50)NYHA (3-4 vs. 1-2) measure: To study the cross-sectional association between multi-omics signatures with clinical sub-phenotypes of heart failure sex: ALL minimumAge: 18 Years maximumAge: 100 Years stdAges: ADULT stdAges: OLDER_ADULT facility: National Heart, Lung and Blood Institute (NHLBI) city: Bethesda state: Maryland zip: 20892 country: United States name: Veronique Roger, M.D. role: CONTACT phone: 301-402-1715 email: veronique.roger@nih.gov lat: 38.98067 lon: -77.10026 hasResults: False
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<|newrecord|> nctId: NCT06280807 id: 10001617 id: 001617-E briefTitle: Observation of Environment and Reproductive-Endocrine Effects overallStatus: RECRUITING date: 2024-05-01 date: 2039-03-28 date: 2039-03-31 date: 2024-02-28 date: 2024-04-26 name: National Institute of Environmental Health Sciences (NIEHS) class: NIH briefSummary: Background:
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Endocrine disorders occur when the glands that make hormones do not work properly. Hormones levels that are too high or too low can cause problems such as late or early puberty, irregular periods, and infertility. Environmental factors - including pollution; chemical exposure at home and work; foods; medicines; and sleep habits - may cause problems with the endocrine and reproductive systems.
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Objective:
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To learn how environmental factors may affect the endocrine and reproductive systems.
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Eligibility:
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Males or females, referring to sex assigned at birth, aged 8 years and older; they must have hypogonadism, infertility, or other reproductive disorders.
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Design:
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Adult participants will have 4 to 5 visits in 5 years. Children may have up to 12 visits; they may remain in the study up to the age of 23. Most visits will be less than 3 hours.
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Participants will be screened. They will have a physical exam. They will have blood and urine tests. They will complete questionnaires; they will answer questions about their diet, health, and other topics. Some may be referred for additional tests, such as imaging scans and semen analysis.
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Specific tests conducted during study visits will vary, depending on the participant s diagnosis. In addition to repeated blood and urine tests, these may include:
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Body composition measure: Participants will sit in a pod-shaped machine for about 6 minutes. The machines measures the air inside the capsule to record body fat and breathing volume.
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Resting energy expenditure test: Participants will lie down with a clear dome placed over their head. They will breathe quietly for 30 minutes. This test measures the number of calories their body burns at rest.
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... conditions: Hypogonadism conditions: Hypergonadism conditions: Precocious Puberty conditions: Late Puberty conditions: Amenorrhea studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: ESTIMATED measure: Investigate the relationship between environment, lifestyle, and reproductive neuroendocrinology. measure: the relationship between nutrition, diet and reproduction measure: the impact of stress on reproductive dysfunction measure: the influence of behavioral and psychological factors on reproductive function sex: ALL minimumAge: 8 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: NIEHS Clinical Research Unit (CRU) status: RECRUITING city: Research Triangle Park state: North Carolina zip: 27709 country: United States name: NIH Clinical Center Office of Patient Recruitment (OPR) role: CONTACT phone: 800-411-1222 phoneExt: TTY dial 711 email: ccopr@nih.gov name: NIEHS Join A Study Recruitment Group role: CONTACT phone: (855) 696-4347 email: myniehs@nih.gov lat: 35.90567 lon: -78.90497 hasResults: False
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<|newrecord|> nctId: NCT06280794 id: Laser-Bell-2024 briefTitle: Efficacy of Laser Acupuncture for Idiopathic Bell's Palsy overallStatus: COMPLETED date: 2022-03-01 date: 2024-01-01 date: 2024-02-01 date: 2024-02-28 date: 2024-03-29 name: Beijing Tongren Hospital class: OTHER briefSummary: Objective:
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Bell's palsy is characterized by acute, unilateral onset that compromises function and esthetics, exerting a considerable impact on the social, professional, and psychological aspects of the lives of affected individuals. The objective of this study was to determine whether laser acupuncture therapy could relieve symptoms in patients with Bell's palsy in 8 weeks.
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Methods:
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This study was randomized controlled trial including 360 patients that undergoing Bell's palsy. All the patients received oral Betahistine Mesylate tablet, Vitamin B1 tablet and Prednisolone.
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Patients were assigned to the laser acupuncture (LA) group, Sham LA group and control group, with 120 patients in each group. LA group and Sham LA group were received 4 weeks of Laser treatment (3 times per week).
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