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1.0alpha7.train.1083
19576956
[ { "id": "1.0alpha7.train.1083.sent", "type": "sentence", "text": [ "Neither the Vg-Sd complex nor Sd alone bound to the shorter 18 mer." ], "offsets": [ [ 0, 70 ] ] } ]
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[]
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1.0alpha7.train.1084
19535186
[ { "id": "1.0alpha7.train.1084.sent", "type": "sentence", "text": [ "Using purified glutathione S-transferase (GST)-fused wild-type (WT) Aurora B, GST-fused kinase-defective (KD) mutant of Aurora B, or GST alone against purified maltose binding protein (MBP)-fused MgcRacGAP, GST pull-down assays were performed in buffer A (25 mM Tris [pH 7.5], 2 mM MgCl2, 200 μM ATP, 0.1 μM calyculin A, 1% Nonidet P-40)." ], "offsets": [ [ 0, 338 ] ] } ]
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[]
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[]
1.0alpha7.train.1085
4330349
[ { "id": "1.0alpha7.train.1085.sent", "type": "sentence", "text": [ "Our results suggest that ATP-BD binds AMP and ATP at two separate sites (see above)." ], "offsets": [ [ 0, 86 ] ] } ]
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[]
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1.0alpha7.train.1086
9047217
[ { "id": "1.0alpha7.train.1086.sent", "type": "sentence", "text": [ "The apparent lack of stoichiometric binding of ORC to ATP may be attributable to several factors." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "1.0alpha7.train.1086.ent0_0", "type": "protein-complex", "text": [ "ORC" ], "offsets": [ [ 48, 51 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1086.ent1_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 57, 60 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] } ]
[]
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1.0alpha7.train.1087
11389367
[ { "id": "1.0alpha7.train.1087.sent", "type": "sentence", "text": [ "Previous studies have indicated that Ras binding localizes Raf-1 to the plasma membrane where it becomes activated and that artificially targeting Raf-1 to the plasma membrane results in constitutive activation of the kinase (Leevers et al., 1994; Stokoe et al., 1994). " ], "offsets": [ [ 0, 270 ] ] } ]
[ { "id": "1.0alpha7.train.1087.ent0_0", "type": "protein", "text": [ "Raf-1" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5894" }, { "db_name": "hgnc", "db_id": "RAF1" }, { "db_name": "uniprot", "db_id": "P04049" } ] }, { "id": "1.0alpha7.train.1087.ent1_1", "type": "protein", "text": [ "Raf-1" ], "offsets": [ [ 147, 152 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5894" }, { "db_name": "hgnc", "db_id": "RAF1" }, { "db_name": "uniprot", "db_id": "P04049" } ] }, { "id": "1.0alpha7.train.1087.ent2_0", "type": "protein-family", "text": [ "Ras" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR020849" } ] } ]
[]
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1.0alpha7.train.1088
7249808
[ { "id": "1.0alpha7.train.1088.sent", "type": "sentence", "text": [ "In comparing DNA binding of Dm and MGTs, it should be noted that the substitution of the amino-terminal formyl and the carboxyl-terminal amidine groups of Dm by acetamido and -CH2CH2N+H(CH3)2 groups, respectively, yields compound 2 along with a three-order of magnitude decrease in binding affinity (K1K2) compared with Dm." ], "offsets": [ [ 0, 323 ] ] } ]
[ { "id": "1.0alpha7.train.1088.ent0_0", "type": "drug", "text": [ "Dm" ], "offsets": [ [ 28, 30 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1088.ent1_1", "type": "drug", "text": [ "Dm" ], "offsets": [ [ 155, 157 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1088.ent2_2", "type": "drug", "text": [ "Dm" ], "offsets": [ [ 320, 322 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1088.ent3_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.1088.ent4_0", "type": "drug", "text": [ "MGTs" ], "offsets": [ [ 35, 39 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1088.ent5_0", "type": "chemical", "text": [ "-CH2CH2N+H(CH3)2" ], "offsets": [ [ 175, 191 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1089
15373301
[ { "id": "1.0alpha7.train.1089.sent", "type": "sentence", "text": [ "It has been shown that the interaction between U2AF35 and the 3' splice site AG can stabilize U2AF65 binding to weak Py tracts characteristic of so-called AG-dependent pre-mRNAs." ], "offsets": [ [ 0, 183 ] ] } ]
[ { "id": "1.0alpha7.train.1089.ent0_0", "type": "RNA", "text": [ "3' splice site AG" ], "offsets": [ [ 64, 81 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1089.ent1_0", "type": "RNA", "text": [ "AG-dependent pre-mRNAs" ], "offsets": [ [ 160, 182 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1089.ent2_0", "type": "protein", "text": [ "U2AF65" ], "offsets": [ [ 97, 103 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11338" }, { "db_name": "hgnc", "db_id": "U2AF2" }, { "db_name": "uniprot", "db_id": "P26368" } ] }, { "id": "1.0alpha7.train.1089.ent3_0", "type": "protein", "text": [ "U2AF35" ], "offsets": [ [ 48, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7307" }, { "db_name": "hgnc", "db_id": "U2AF1" }, { "db_name": "uniprot", "db_id": "Q01081" } ] }, { "id": "1.0alpha7.train.1089.ent4_0", "type": "DNA", "text": [ "Py tracts" ], "offsets": [ [ 121, 130 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1090
9106838
[ { "id": "1.0alpha7.train.1090.sent", "type": "sentence", "text": [ "In contrast, hPAK65 interacts strongly with the GTP-bound forms of both Rac1 and CDC42Hs." ], "offsets": [ [ 0, 94 ] ] } ]
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[]
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1.0alpha7.train.1091
16329547
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[]
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1.0alpha7.train.1092
888198
[ { "id": "1.0alpha7.train.1092.sent", "type": "sentence", "text": [ "Calmodulin binding activities of the adducin recombinant polypeptides and the MARCKS-related domain peptide were inhibited by PKA and PKC phosphorylation." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.1093
8949381
[ { "id": "1.0alpha7.train.1093.sent", "type": "sentence", "text": [ "We delineated the region of LIN-7 that binds to LIN-2 by generating a series of LIN-7 fusion proteins that contained successively larger N-terminal truncations." ], "offsets": [ [ 0, 165 ] ] } ]
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[]
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1.0alpha7.train.1094
1106224
[ { "id": "1.0alpha7.train.1094.sent", "type": "sentence", "text": [ "Characterization of rC Domain Binding to Fibronectin, Laminin, SPARC, and Tenascin" ], "offsets": [ [ 0, 82 ] ] } ]
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[]
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1.0alpha7.train.1095
4176167
[ { "id": "1.0alpha7.train.1095.sent", "type": "sentence", "text": [ "The introduction of a glutamic acid residue at position 12 in place of the tyrosine residue similarly reduced the binding of alpha-actinin to actin." ], "offsets": [ [ 0, 151 ] ] } ]
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[]
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1.0alpha7.train.1096
4626814
[ { "id": "1.0alpha7.train.1096.sent", "type": "sentence", "text": [ "As a negative control, we found that GST alone did not bind MBP-Sec3p under the same reaction conditions." ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.1097
11580554
[ { "id": "1.0alpha7.train.1097.sent", "type": "sentence", "text": [ "Interestingly, Abl binds to the proline-rich sequences found in formin proteins ( Ren et al., 1993) and to Ena ( Gertler et al., 1995), which also bind to profilin." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "1.0alpha7.train.1097.ent0_0", "type": "protein-motif", "text": [ "proline-rich sequences" ], "offsets": [ [ 34, 56 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1097.ent1_0", "type": "protein-family", "text": [ "Abl" ], "offsets": [ [ 16, 19 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR033221" } ] }, { "id": "1.0alpha7.train.1097.ent2_0", "type": "protein-family", "text": [ "formin" ], "offsets": [ [ 67, 73 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001265" } ] } ]
[]
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1.0alpha7.train.1098
9252669
[ { "id": "1.0alpha7.train.1098.sent", "type": "sentence", "text": [ "Overexpression of wild-type raptor, but not of a mutant that cannot interact with mTOR (mut 1 in Figure 4), resulted in an increased amount of raptor bound to mTOR and a decrease in its in vitro kinase activity (Figure 6E)." ], "offsets": [ [ 0, 236 ] ] } ]
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[]
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1.0alpha7.train.1099
3616077
[ { "id": "1.0alpha7.train.1099.sent", "type": "sentence", "text": [ "Finally, footprinting analyses using the -73 to +13 promoter sequence did not reveal any protected nucleotides in the wild-type and mutated promoter sequences, under conditions which detected strong c-Jun binding to the AP-1 binding site (data not shown)." ], "offsets": [ [ 0, 255 ] ] } ]
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[]
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1.0alpha7.train.1100
9115233
[ { "id": "1.0alpha7.train.1100.sent", "type": "sentence", "text": [ "Thus, it appears that the holoenzyme can partially stabilize binding of TBP and TFIIA to a mononucleosome in the absence of ATP." ], "offsets": [ [ 0, 132 ] ] } ]
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[]
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1.0alpha7.train.1101
9285508
[ { "id": "1.0alpha7.train.1101.sent", "type": "sentence", "text": [ "Because the N-terminal binding sequences of syntaxins are distant from the SNARE motifs, the corresponding SM proteins bind equally well to the isolated syntaxins and to assembled SNARE complexes (Peng and Gallwitz, 2002 )." ], "offsets": [ [ 0, 228 ] ] } ]
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[]
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1.0alpha7.train.1102
11814240
[ { "id": "1.0alpha7.train.1102.sent", "type": "sentence", "text": [ "LDB proteins bind LIM domains of LIM-HD (and nuclear LIM-only) proteins." ], "offsets": [ [ 0, 75 ] ] } ]
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[]
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1.0alpha7.train.1103
15755253
[ { "id": "1.0alpha7.train.1103.sent", "type": "sentence", "text": [ "p21 induction and its binding to cdk2 are also observed following p16 expression in HCT 116 colorectal carcinoma cells." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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1.0alpha7.train.1104
4585198
[ { "id": "1.0alpha7.train.1104.sent", "type": "sentence", "text": [ "Thus, like Arg65 in MKP3, Asp319 in ERK2 plays a major role in ERK2 binding to MKP3, but it is not essential for ERK2-induced MKP3 activation." ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.1105
859695
[ { "id": "1.0alpha7.train.1105.sent", "type": "sentence", "text": [ "The recombinant second C -domain of SytI also binds syntaxin (see Fig. 3) and phospholipids (Damer and Creutz, 1994) in a Ca -independent manner." ], "offsets": [ [ 0, 151 ] ] } ]
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1.0alpha7.train.1106
4094081
[ { "id": "1.0alpha7.train.1106.sent", "type": "sentence", "text": [ "In contrast to their effects on cell proliferation, peptides containing either a single copy of the receptor binding domain or the distal heparin binding domain of apoE did not inhibit PDGF-directed smooth muscle cell migration." ], "offsets": [ [ 0, 232 ] ] } ]
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[]
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1.0alpha7.train.1107
317429
[ { "id": "1.0alpha7.train.1107.sent", "type": "sentence", "text": [ "These results clearly demonstrate that Ca -dependent binding of synaptotagmin to syntaxin 1 involves structural features distinct from those required for the Ca -dependent interaction of synaptotagmin with phospholipids." ], "offsets": [ [ 0, 227 ] ] } ]
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[]
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1.0alpha7.train.1108
2951285
[ { "id": "1.0alpha7.train.1108.sent", "type": "sentence", "text": [ "The DNA binding activity of TTF-1 in thyroid cells has been reported to be under TSH control because of redox regulation (19) even though TTF-1 mRNA appears to be down-regulated by the hormone (41, 42). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.1109
8895279
[ { "id": "1.0alpha7.train.1109.sent", "type": "sentence", "text": [ "The addition to permeabilized cells of PH domains that bind PI(4,5)P2 inhibits both early and late stages of clathrin-mediated endocytosis (Jost et al., 1998 )." ], "offsets": [ [ 0, 166 ] ] } ]
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[]
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1.0alpha7.train.1110
9152847
[ { "id": "1.0alpha7.train.1110.sent", "type": "sentence", "text": [ "This correlation is mediated at least in part by the binding of Snail to the E-cadherin promoter where it acts as a transcriptional repressor." ], "offsets": [ [ 0, 149 ] ] } ]
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[]
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1.0alpha7.train.1111
2068054
[ { "id": "1.0alpha7.train.1111.sent", "type": "sentence", "text": [ "From these data we observed a small increase in the percent of WT coat protein bound to GroEL with increasing temperature." ], "offsets": [ [ 0, 124 ] ] } ]
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[]
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1.0alpha7.train.1112
1397019
[ { "id": "1.0alpha7.train.1112.sent", "type": "sentence", "text": [ "Nevertheless, the binding of NF1 and Sp1 to oligo II in vitro is mutually exclusive as indicated by the results of DMSA, which is consistent with the lack of additivity in the activation of the P2 promoter by these two factors in vivo." ], "offsets": [ [ 0, 241 ] ] } ]
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[]
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1.0alpha7.train.1113
22867123
[ { "id": "1.0alpha7.train.1113.sent", "type": "sentence", "text": [ "[Abstract] arki S, Holzbaur ELF (1995) Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.1114
3631956
[ { "id": "1.0alpha7.train.1114.sent", "type": "sentence", "text": [ "Lysine residue at 721 within the kinase domain is believed to be involved in ATP binding, and replacement of this lysine with methionine abrogates receptor tyrosine kinase activity." ], "offsets": [ [ 0, 185 ] ] } ]
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[]
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[]
1.0alpha7.train.1115
9863818
[ { "id": "1.0alpha7.train.1115.sent", "type": "sentence", "text": [ "We have shown that full-length Tsg101 binds Hrs (and COOH-terminal fragments), and that COOH-terminal Hrs fragments can support Tsg101-dependent plasma membrane vesicle fission in a heterologous VLP system." ], "offsets": [ [ 0, 212 ] ] } ]
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[]
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1.0alpha7.train.1116
9426251
[ { "id": "1.0alpha7.train.1116.sent", "type": "sentence", "text": [ "To evaluate cadherin- or TCF-binding capacity of β-catenin in SW480 cells, a cell lysate (1% nonidet 40–containing buffer) or 100,000-g detergent-free supernatant (Reinacher-Schick and Gumbiner 2001) was subjected to consecutive affinity precipitations (30′ incubations × 3) with a glutathione S-transferase (GST) fusion protein containing the cytoplasmic domain of C-cadherin (Yap et al. 1998) or the β-catenin binding region of Xenopus TCF-3." ], "offsets": [ [ 0, 444 ] ] } ]
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1.0alpha7.train.1117
11265972
[ { "id": "1.0alpha7.train.1117.sent", "type": "sentence", "text": [ "The binding of AP-3 to LIMP-II was characterized in more detail and shown to depend on leucine 18, which is a critical component of the di-leucine-based motif involved in the sorting of LIMP-II to lysosomes (Ogata and Fukuda, 1994 ; Sandoval et al." ], "offsets": [ [ 0, 255 ] ] } ]
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[]
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1.0alpha7.train.1118
913078
[ { "id": "1.0alpha7.train.1118.sent", "type": "sentence", "text": [ "This time course of ATP inhibition correlates well with the activation of HSF binding by salicylate indicating that decreases in intracellular ATP may be an important factor in the activation of HSF binding by this drug." ], "offsets": [ [ 0, 225 ] ] } ]
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[]
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1.0alpha7.train.1119
6274318
[ { "id": "1.0alpha7.train.1119.sent", "type": "sentence", "text": [ "We may then use the crystal structure model ( 33) of an archael Cdc6 ortholog as a guide for the ATP-binding structures of ORC1." ], "offsets": [ [ 0, 131 ] ] } ]
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[]
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1.0alpha7.train.1120
2742044
[ { "id": "1.0alpha7.train.1120.sent", "type": "sentence", "text": [ "These results provide evidence that complex 2 is due to binding of Sp1 to the CACCC box; however, complex 1 appears to be due to a distinct factor(s), perhaps a Krüppel-like protein, that is specifically induced during Me2SO-induced neuronal differentiation of N1E-115 cells." ], "offsets": [ [ 0, 275 ] ] } ]
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[]
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1.0alpha7.train.1121
1084881
[ { "id": "1.0alpha7.train.1121.sent", "type": "sentence", "text": [ "However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70." ], "offsets": [ [ 0, 150 ] ] } ]
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[]
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1.0alpha7.train.1122
22499501
[ { "id": "1.0alpha7.train.1122.sent", "type": "sentence", "text": [ "Although CD19 function may be elicited following its potential binding to an as yet unidentified ligand, C3d binding to CD21 supplies an already characterized ligand for the CD19 complex, thereby linking complement activation and B cell function." ], "offsets": [ [ 0, 252 ] ] } ]
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[]
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1.0alpha7.train.1123
15178734
[ { "id": "1.0alpha7.train.1123.sent", "type": "sentence", "text": [ "From these results we conclude that the binding of p300 and SAF-A to the MII S/MAR element, as observed in U-2 OS and VH10 cells, is absent in SV40- and adenovirus-transformed cells." ], "offsets": [ [ 0, 187 ] ] } ]
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[]
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1.0alpha7.train.1124
201440
[ { "id": "1.0alpha7.train.1124.sent", "type": "sentence", "text": [ "The lack of protein 4.1 binding to the truncated fusion protein therefore suggests that residues located in the C-terminal half of the 39-amino acid region may be necessary for the binding of p55 to protein 4.1 ( Fig. 6 )." ], "offsets": [ [ 0, 229 ] ] } ]
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[]
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1.0alpha7.train.1125
12959597
[ { "id": "1.0alpha7.train.1125.sent", "type": "sentence", "text": [ "However, its binding to the GTP-bound forms of Rac1, Rac2, and RhoA and its slight effect on dorsal closure suggest that pkn may function as an effector of Rac or that it may be a redundant effector during dorsal closure." ], "offsets": [ [ 0, 227 ] ] } ]
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[]
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1.0alpha7.train.1126
2062853
[ { "id": "1.0alpha7.train.1126.sent", "type": "sentence", "text": [ "In the presence of caldesmon, fascin does not inhibit actin binding of high Mr TMs at a concentration below 2 μM fascin (closed circles)." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "1.0alpha7.train.1126.ent0_0", "type": "protein-family", "text": [ "TMs" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000533" } ] }, { "id": "1.0alpha7.train.1126.ent1_0", "type": "protein-family", "text": [ "fascin" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR010431" } ] }, { "id": "1.0alpha7.train.1126.ent2_1", "type": "protein-family", "text": [ "fascin" ], "offsets": [ [ 113, 119 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR010431" } ] }, { "id": "1.0alpha7.train.1126.ent3_0", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 19, 28 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.1126.ent4_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 54, 59 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.1126.ent5_0", "type": "protein", "text": [ "Mr TMs" ], "offsets": [ [ 76, 82 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1127
15955979
[ { "id": "1.0alpha7.train.1127.sent", "type": "sentence", "text": [ "To control for the specificity of 12S E1A-dependent inhibition of Gal-Ets 2-440, we also used a CBP-independent activator, Gal-CREB 160-284, which fuses the Gal DBD to the glutamine-rich activation domain of CREB, termed Q2 (Q2 binds the TFIID component dTAF110 [16, 25, 61, 77]). " ], "offsets": [ [ 0, 281 ] ] } ]
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[]
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1.0alpha7.train.1128
15100994
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[]
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1.0alpha7.train.1129
15810861
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[]
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1.0alpha7.train.1130
11542231
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[]
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1.0alpha7.train.1131
1138398
[ { "id": "1.0alpha7.train.1131.sent", "type": "sentence", "text": [ "This result suggests that 317Y/F- Shc binds to the insulin receptor upon insulin stimulation, but that it subsequently fails to bind to Grb2." ], "offsets": [ [ 0, 143 ] ] } ]
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[]
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1.0alpha7.train.1132
9284858
[ { "id": "1.0alpha7.train.1132.sent", "type": "sentence", "text": [ "Owing to the higher concentration of ATP in living cells and its higher affinity for actin than ADP, nucleotide-free actin preferentially binds ATP." ], "offsets": [ [ 0, 153 ] ] } ]
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[]
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1.0alpha7.train.1133
420238
[ { "id": "1.0alpha7.train.1133.sent", "type": "sentence", "text": [ "In vitro biochemical studies using purified Swi5p and Pho2p proteins have demonstrated that Swi5p and Pho2p bind cooperatively to the HO promoter." ], "offsets": [ [ 0, 146 ] ] } ]
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[]
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1.0alpha7.train.1134
2589889
[ { "id": "1.0alpha7.train.1134.sent", "type": "sentence", "text": [ "Observed destabilization of troponin-tropomyosin binding to actin in the presence of Ca2+, a 1.4-fold effect, provides a partial explanation." ], "offsets": [ [ 0, 143 ] ] } ]
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[]
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1.0alpha7.train.1135
8918506
[ { "id": "1.0alpha7.train.1135.sent", "type": "sentence", "text": [ "Second, binding of Net1 to Cdc14 inhibits the protein phosphatase activity of Cdc14 in vitro, and net1 mutants display elevated Cdc14 protein phosphatase activity." ], "offsets": [ [ 0, 172 ] ] } ]
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[]
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1.0alpha7.train.1136
9246155
[ { "id": "1.0alpha7.train.1136.sent", "type": "sentence", "text": [ "The latter event also facilitates binding of dATP (or ATP) by Apaf-1, which may lock the molecule into a more open configuration and permit oligomerization and caspase-9 recruitment." ], "offsets": [ [ 0, 186 ] ] } ]
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[]
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1.0alpha7.train.1137
17536429
[ { "id": "1.0alpha7.train.1137.sent", "type": "sentence", "text": [ "We reasoned that the homology of the heparin binding motifs of apoE and Abeta revealed by the immunochemical studies was responsible for the competition of Abeta for the uptake of apoE-enriched betaVLDL." ], "offsets": [ [ 0, 208 ] ] } ]
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[]
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1.0alpha7.train.1138
9505829
[ { "id": "1.0alpha7.train.1138.sent", "type": "sentence", "text": [ "The results further suggest that interactions involving factors that define mRNP composition occur as early as the commitment stage of splicing complex formation, when U1 snRNP and SR family proteins bind to the pre-mRNA and facilitate the association of factors including SRm160/300 and DEK with the substrate (Blencowe et al. 1998; present study)." ], "offsets": [ [ 0, 349 ] ] } ]
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[]
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1.0alpha7.train.1139
9029833
[ { "id": "1.0alpha7.train.1139.sent", "type": "sentence", "text": [ "One proposal for how the UTRs repress protein production is that SXL binds to the UTRs of msl-2 mRNA and blocks the export of these mRNAs from the nucleus." ], "offsets": [ [ 0, 163 ] ] } ]
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[]
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1.0alpha7.train.1140
6594389
[ { "id": "1.0alpha7.train.1140.sent", "type": "sentence", "text": [ "Binding of tTA to tetO results in activation of expression of the proapoptotic gene hid." ], "offsets": [ [ 0, 91 ] ] } ]
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[]
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1.0alpha7.train.1141
9377965
[ { "id": "1.0alpha7.train.1141.sent", "type": "sentence", "text": [ "Filamin-B binds to GP-Ibα (Takafuta et al., 1998; Xu et al., 1998), whereas the muscle-associated filamin-C binds to sarcoglycans (Thompson et al., 2000) and a number of muscle-specific proteins (Faulkner et al., 2000; van der Ven et al., 2000; Takada et al., 2001). " ], "offsets": [ [ 0, 267 ] ] } ]
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[]
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1.0alpha7.train.1142
3472890
[ { "id": "1.0alpha7.train.1142.sent", "type": "sentence", "text": [ "In contrast, dGTP and dADP could not compete for dATP binding to Apaf-1 at all." ], "offsets": [ [ 0, 82 ] ] } ]
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[]
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1.0alpha7.train.1143
15589644
[ { "id": "1.0alpha7.train.1143.sent", "type": "sentence", "text": [ "On the other hand, CBP/p300 could still function as a “glue” to bring together ER81 and transcription factors binding outside CBP region 451 to 721, such as Fos or nuclear hormone receptors (18), and thereby facilitate cooperation between different classes of transcription factors at selected promoters containing respective DNA-binding sites." ], "offsets": [ [ 0, 344 ] ] } ]
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[]
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[]
1.0alpha7.train.1144
16013438
[ { "id": "1.0alpha7.train.1144.sent", "type": "sentence", "text": [ "These findings strongly suggest that E2Fs bound to both E2F sites present in the promoter have both a negative role (when bound to pocket proteins) and a positive role in the regulation of CDC6 expression." ], "offsets": [ [ 0, 210 ] ] } ]
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[]
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1.0alpha7.train.1145
4879612
[ { "id": "1.0alpha7.train.1145.sent", "type": "sentence", "text": [ "This is most likely due to the binding of Ubc9 directly to GR (Fig. 3)." ], "offsets": [ [ 0, 74 ] ] } ]
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[]
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1.0alpha7.train.1146
3705598
[ { "id": "1.0alpha7.train.1146.sent", "type": "sentence", "text": [ "A, p65 binds to AES and IkappaBalpha in vitro." ], "offsets": [ [ 0, 49 ] ] } ]
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[]
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1.0alpha7.train.1147
11386430
[ { "id": "1.0alpha7.train.1147.sent", "type": "sentence", "text": [ "These data suggest that the binding of Sp1 and NF-kappaB1 to the HIV-1 mononucleosomes does not disrupt histone-DNA contacts sufficiently to allow SWI-SNF-mediated histone displacement." ], "offsets": [ [ 0, 191 ] ] } ]
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[]
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1.0alpha7.train.1148
19641115
[ { "id": "1.0alpha7.train.1148.sent", "type": "sentence", "text": [ "To test whether Ras mutant cells within the dorsal appendage primordia undergo this shape change, we carried out confocal analyses of mosaic egg chambers in which we simultaneously detected Ras clones and visualized cell morphology using one of two reagents: rhodamine-phalloidin, which binds to filamentous actin, or anti-E-cadherin, which highlights apical morphology (Fig. 6A)." ], "offsets": [ [ 0, 380 ] ] } ]
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[]
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1.0alpha7.train.1149
7357572
[ { "id": "1.0alpha7.train.1149.sent", "type": "sentence", "text": [ "HxPros enhances the binding of Dfd and Hoxa-5 to DNA by more than 10-fold (Fig. 3 A, and not shown)." ], "offsets": [ [ 0, 103 ] ] } ]
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[]
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1.0alpha7.train.1150
6510446
[ { "id": "1.0alpha7.train.1150.sent", "type": "sentence", "text": [ "Similarly, p53, E1A, c-Fos, c-Jun, MyoD, and TFIIB all interact with the CH3 region of p300/CBP, and these factors would likely interfere with the TCF binding to p300/CBP." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
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1.0alpha7.train.1151
6233579
[ { "id": "1.0alpha7.train.1151.sent", "type": "sentence", "text": [ "The convex shape of the Scatchard plot indicated that Arg binds to F-actin with positive cooperativity (Fig. 1 G; ref. 19)." ], "offsets": [ [ 0, 127 ] ] } ]
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[]
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1.0alpha7.train.1152
16469619
[ { "id": "1.0alpha7.train.1152.sent", "type": "sentence", "text": [ "Because roX RNAs are unstable unless bound by MSL proteins ( 13, 15), steady-state levels of one roX RNA species might fall if another roX species captured most MSL proteins." ], "offsets": [ [ 0, 183 ] ] } ]
[ { "id": "1.0alpha7.train.1152.ent0_0", "type": "RNA-family", "text": [ "roX" ], "offsets": [ [ 10, 13 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1152.ent1_1", "type": "RNA-family", "text": [ "roX" ], "offsets": [ [ 103, 106 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1152.ent2_2", "type": "RNA-family", "text": [ "roX" ], "offsets": [ [ 143, 146 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1152.ent3_0", "type": "RNA-family", "text": [ "roX RNAs" ], "offsets": [ [ 10, 18 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1152.ent4_0", "type": "protein-family", "text": [ "MSL" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1152.ent5_1", "type": "protein-family", "text": [ "MSL" ], "offsets": [ [ 170, 173 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1153
25250704
[ { "id": "1.0alpha7.train.1153.sent", "type": "sentence", "text": [ "Translocation requires another homeobox protein, homothorax, which binds extradenticle and enables nuclear entry ( Rieckhof et al. 1997 )." ], "offsets": [ [ 0, 142 ] ] } ]
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[]
[ { "id": "1.0alpha7.train.1153.coref0", "entity_ids": [ "1.0alpha7.train.1153.ent0_0" ] }, { "id": "1.0alpha7.train.1153.coref1", "entity_ids": [ "1.0alpha7.train.1153.ent1_0" ] } ]
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1.0alpha7.train.1154
12633833
[ { "id": "1.0alpha7.train.1154.sent", "type": "sentence", "text": [ "On the basis of studies using yeast and Xenopus cells, Cdc6p most likely binds to ORC and then the ORC-Cdc6p complex (and perhaps other proteins) recruits the six minichromosome maintenance (MCM) proteins to form a pre-replication complex (pre-RC) at each origin (Cocker et al. 1996; Santocanale and Diffley 1996; Aparicio et al. 1997; Donovan et al. 1997; Liang and Stillman 1997; Tanaka et al. 1997; Perkins and Diffley 1998; Weinreich et al. 1999)." ], "offsets": [ [ 0, 451 ] ] } ]
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[]
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1.0alpha7.train.1155
3400389
[ { "id": "1.0alpha7.train.1155.sent", "type": "sentence", "text": [ "2) This region is involved in the interaction of C/EBPbeta with other modulating proteins bound to neighboring cis-regulatory sites, creating structural changes ( 27)." ], "offsets": [ [ 0, 170 ] ] } ]
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[]
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[]
1.0alpha7.train.1156
6093837
[ { "id": "1.0alpha7.train.1156.sent", "type": "sentence", "text": [ "In particular, overexpression of TDP-43 could cause exon-skipping of the CTFR exon 9, and this skipping is through TDP-43 binding to a (UG) m(U)n motif near the 3′ splice site of the CTFR intron 8 (13)." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "1.0alpha7.train.1156.ent0_0", "type": "DNA", "text": [ "(UG) m(U)n motif" ], "offsets": [ [ 135, 151 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1156.ent1_0", "type": "protein", "text": [ "TDP-43" ], "offsets": [ [ 33, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23435" }, { "db_name": "hgnc", "db_id": "TARDBP" }, { "db_name": "uniprot", "db_id": "Q13148" } ] }, { "id": "1.0alpha7.train.1156.ent2_1", "type": "protein", "text": [ "TDP-43" ], "offsets": [ [ 115, 121 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23435" }, { "db_name": "hgnc", "db_id": "TARDBP" }, { "db_name": "uniprot", "db_id": "Q13148" } ] }, { "id": "1.0alpha7.train.1156.ent3_0", "type": "gene", "text": [ "CTFR" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1080" }, { "db_name": "hgnc", "db_id": "CFTR" } ] }, { "id": "1.0alpha7.train.1156.ent4_1", "type": "gene", "text": [ "CTFR" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1080" }, { "db_name": "hgnc", "db_id": "CFTR" } ] }, { "id": "1.0alpha7.train.1156.ent5_0", "type": "DNA", "text": [ "CTFR intron 8" ], "offsets": [ [ 183, 196 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1156.ent6_0", "type": "DNA", "text": [ "CTFR exon 9" ], "offsets": [ [ 73, 84 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1157
15268262
[ { "id": "1.0alpha7.train.1157.sent", "type": "sentence", "text": [ "It has been shown that a family of elav-like proteins binds to an AU-rich sequence located within the 3' untranslated region ( UTR) of certain mRNAs and increases the stability of these mRNAs ( 6, 11, 12, 26, 35)." ], "offsets": [ [ 0, 219 ] ] } ]
[ { "id": "1.0alpha7.train.1157.ent0_0", "type": "protein-family", "text": [ "elav-like proteins" ], "offsets": [ [ 36, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1157.ent1_0", "type": "RNA", "text": [ "AU-rich sequence" ], "offsets": [ [ 68, 84 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1157.ent2_0", "type": "RNA", "text": [ "mRNAs" ], "offsets": [ [ 145, 150 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1157.ent3_1", "type": "RNA", "text": [ "mRNAs" ], "offsets": [ [ 188, 193 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1157.ent4_0", "type": "RNA", "text": [ "UTR" ], "offsets": [ [ 129, 132 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1157.ent5_0", "type": "RNA", "text": [ "3' untranslated region" ], "offsets": [ [ 104, 126 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1158
1550990
[ { "id": "1.0alpha7.train.1158.sent", "type": "sentence", "text": [ "Because HSPGs have been detected immunohistochemically in the pancreatic amyloid deposits of type II diabetes ( 35), we investigated the binding of amylin to heparin." ], "offsets": [ [ 0, 170 ] ] } ]
[ { "id": "1.0alpha7.train.1158.ent0_0", "type": "peptide", "text": [ "amyloid" ], "offsets": [ [ 74, 81 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1158.ent1_0", "type": "chemical", "text": [ "heparin" ], "offsets": [ [ 162, 169 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "772" } ] }, { "id": "1.0alpha7.train.1158.ent2_0", "type": "chemical", "text": [ "HSPGs" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1158.ent3_0", "type": "peptide", "text": [ "amylin" ], "offsets": [ [ 151, 157 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1158.ent4_0", "type": "disease", "text": [ "type II diabetes" ], "offsets": [ [ 95, 111 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1159
6005656
[ { "id": "1.0alpha7.train.1159.sent", "type": "sentence", "text": [ "These data may therefore indicate that binding of PS to Nct leads to the accumulation of a stable protein complex composed of mature Nct and PS fragments." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.1160
6264998
[ { "id": "1.0alpha7.train.1160.sent", "type": "sentence", "text": [ "By this screening, we show that this interaction occurs in vivo and, further, that TAFII55 binds TAFII250 in the 848-1279 region of TAFII250." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "1.0alpha7.train.1160.ent0_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 100, 108 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.1160.ent1_1", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.1160.ent2_0", "type": "protein", "text": [ "TAFII55" ], "offsets": [ [ 85, 92 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6879" }, { "db_name": "hgnc", "db_id": "TAF7" }, { "db_name": "uniprot", "db_id": "Q15545" } ] } ]
[]
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1.0alpha7.train.1161
3771194
[ { "id": "1.0alpha7.train.1161.sent", "type": "sentence", "text": [ "Electrophoretic mobility shift assays (EMSA) show that Sp1 and Sp3 bind the Sp1 element, whereas transcription factors binding to the Ets-1 element are yet to be identified." ], "offsets": [ [ 0, 178 ] ] } ]
[ { "id": "1.0alpha7.train.1161.ent0_0", "type": "assay", "text": [ "Electrophoretic mobility shift assays" ], "offsets": [ [ 0, 37 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1161.ent1_0", "type": "assay", "text": [ "EMSA" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1161.ent2_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.1161.ent3_1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.1161.ent4_0", "type": "protein", "text": [ "Sp3" ], "offsets": [ [ 65, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6670" }, { "db_name": "hgnc", "db_id": "SP3" }, { "db_name": "uniprot", "db_id": "Q02447" } ] }, { "id": "1.0alpha7.train.1161.ent5_0", "type": "DNA", "text": [ "Ets-1 element" ], "offsets": [ [ 139, 152 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1161.ent6_0", "type": "DNA", "text": [ "Sp1 element" ], "offsets": [ [ 79, 90 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1162
6658594
[ { "id": "1.0alpha7.train.1162.sent", "type": "sentence", "text": [ "p53 specifically binds to its consensus DNA binding sequence, consisting of two repeats of 10-bp motif 5-PuPuPuC (A/T)(T/A)GPyPyPy-3(2), and transactivates expression of the target genes." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "1.0alpha7.train.1162.ent0_0", "type": "DNA", "text": [ "5-PuPuPuC (A/T)(T/A)GPyPyPy-3(2)" ], "offsets": [ [ 104, 136 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1162.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.1162.ent2_0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] } ]
[]
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1.0alpha7.train.1163
9305276
[ { "id": "1.0alpha7.train.1163.sent", "type": "sentence", "text": [ "Although the E1A data are consistent with this view, E1A also binds p107 and p130, and these proteins can also associate with E2F target promoters in senescent cells." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "1.0alpha7.train.1163.ent0_0", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.1163.ent1_1", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 55, 58 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.1163.ent2_0", "type": "DNA", "text": [ "E2F target promoters" ], "offsets": [ [ 131, 151 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1163.ent3_0", "type": "protein", "text": [ "p107" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5933" }, { "db_name": "hgnc", "db_id": "RBL1" }, { "db_name": "uniprot", "db_id": "P28749" } ] }, { "id": "1.0alpha7.train.1163.ent4_0", "type": "protein", "text": [ "p130" ], "offsets": [ [ 81, 85 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5934" }, { "db_name": "hgnc", "db_id": "RBL2" }, { "db_name": "uniprot", "db_id": "Q08999" } ] }, { "id": "1.0alpha7.train.1163.ent5_0", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 131, 134 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] } ]
[]
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1.0alpha7.train.1164
9615369
[ { "id": "1.0alpha7.train.1164.sent", "type": "sentence", "text": [ "(B) PAK bound to PIX as previously reported." ], "offsets": [ [ 0, 47 ] ] } ]
[ { "id": "1.0alpha7.train.1164.ent0_0", "type": "protein-family", "text": [ "PIX" ], "offsets": [ [ 20, 23 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1164.ent1_0", "type": "protein-family", "text": [ "PAK" ], "offsets": [ [ 6, 9 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1165
1128818
[ { "id": "1.0alpha7.train.1165.sent", "type": "sentence", "text": [ "Because the GTP-bound form of Ras is a key transducer in the mitogen signaling pathway ( 18), we decided to examine Ras GTP loading in anchored or suspended 3T3 cells treated with either PDGF or EGF." ], "offsets": [ [ 0, 204 ] ] } ]
[ { "id": "1.0alpha7.train.1165.ent0_0", "type": "cell", "text": [ "3T3 cells" ], "offsets": [ [ 160, 169 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1165.ent1_0", "type": "process", "text": [ "mitogen signaling pathway" ], "offsets": [ [ 63, 88 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1165.ent2_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.1165.ent3_1", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 123, 126 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.1165.ent4_0", "type": "protein-family", "text": [ "PDGF" ], "offsets": [ [ 191, 195 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000072" } ] }, { "id": "1.0alpha7.train.1165.ent5_0", "type": "protein-family", "text": [ "Ras" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR020849" } ] }, { "id": "1.0alpha7.train.1165.ent6_1", "type": "protein-family", "text": [ "Ras" ], "offsets": [ [ 119, 122 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR020849" } ] }, { "id": "1.0alpha7.train.1165.ent7_0", "type": "protein", "text": [ "GTP-bound form of Ras" ], "offsets": [ [ 13, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1165.ent8_0", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 200, 203 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] } ]
[]
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1.0alpha7.train.1166
23643809
[ { "id": "1.0alpha7.train.1166.sent", "type": "sentence", "text": [ "However, our previous overlay experiment showed a direct binding between dSlo and PKAc, suggesting a novel channel-PKA protein complex." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "1.0alpha7.train.1166.ent0_0", "type": "protein", "text": [ "dSlo" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q03720" } ] }, { "id": "1.0alpha7.train.1166.ent1_0", "type": "protein-complex", "text": [ "PKA" ], "offsets": [ [ 117, 120 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1166.ent2_0", "type": "protein", "text": [ "PKAc" ], "offsets": [ [ 84, 88 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5566" }, { "db_name": "hgnc", "db_id": "PRKACA" }, { "db_name": "uniprot", "db_id": "P17612" } ] } ]
[]
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1.0alpha7.train.1167
11401954
[ { "id": "1.0alpha7.train.1167.sent", "type": "sentence", "text": [ "In addition to binding Nck in vitro, NIK also bound Nck in cells." ], "offsets": [ [ 0, 69 ] ] } ]
[ { "id": "1.0alpha7.train.1167.ent0_0", "type": "protein", "text": [ "NIK" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9020" }, { "db_name": "hgnc", "db_id": "MAP3K14" }, { "db_name": "uniprot", "db_id": "Q99558" } ] }, { "id": "1.0alpha7.train.1167.ent1_0", "type": "protein-family", "text": [ "Nck" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR017304" } ] }, { "id": "1.0alpha7.train.1167.ent2_1", "type": "protein-family", "text": [ "Nck" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR017304" } ] } ]
[]
[ { "id": "1.0alpha7.train.1167.coref0", "entity_ids": [ "1.0alpha7.train.1167.ent0_0" ] }, { "id": "1.0alpha7.train.1167.coref1", "entity_ids": [ "1.0alpha7.train.1167.ent1_0", "1.0alpha7.train.1167.ent2_1" ] } ]
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1.0alpha7.train.1168
17563740
[ { "id": "1.0alpha7.train.1168.sent", "type": "sentence", "text": [ "This suggests that binding of Sp1 to the Ctpct promoter was saturated." ], "offsets": [ [ 0, 73 ] ] } ]
[ { "id": "1.0alpha7.train.1168.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 31, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.1168.ent1_0", "type": "gene", "text": [ "Ctpct" ], "offsets": [ [ 44, 49 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1168.ent2_0", "type": "DNA", "text": [ "Ctpct promoter" ], "offsets": [ [ 44, 58 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1168.coref0", "entity_ids": [ "1.0alpha7.train.1168.ent0_0" ] }, { "id": "1.0alpha7.train.1168.coref1", "entity_ids": [ "1.0alpha7.train.1168.ent1_0" ] }, { "id": "1.0alpha7.train.1168.coref2", "entity_ids": [ "1.0alpha7.train.1168.ent2_0" ] } ]
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1.0alpha7.train.1169
22183535
[ { "id": "1.0alpha7.train.1169.sent", "type": "sentence", "text": [ "Heparin-binding activity of apoE was also proposed to be responsible for the inhibitory role of apoE in cell growth [ 8." ], "offsets": [ [ 0, 123 ] ] } ]
[ { "id": "1.0alpha7.train.1169.ent0_0", "type": "chemical", "text": [ "Heparin" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "772" } ] }, { "id": "1.0alpha7.train.1169.ent1_0", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 29, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.1169.ent2_1", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] } ]
[]
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1.0alpha7.train.1170
240035
[ { "id": "1.0alpha7.train.1170.sent", "type": "sentence", "text": [ "Although mutation of the Sp1 site did not block p53 binding, it affected p53 binding in a significant manner, ranging from 50% to 25% of p53 bound to the Sp1 mutant probe relative to the native probe ( Fig. 1 E, lane 3)." ], "offsets": [ [ 0, 231 ] ] } ]
[ { "id": "1.0alpha7.train.1170.ent0_0", "type": "DNA", "text": [ "Sp1 site" ], "offsets": [ [ 27, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1170.ent1_0", "type": "experimental-construct", "text": [ "Sp1 mutant probe" ], "offsets": [ [ 163, 180 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1170.ent2_0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 51, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] }, { "id": "1.0alpha7.train.1170.ent3_1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 77, 80 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] }, { "id": "1.0alpha7.train.1170.ent4_2", "type": "protein", "text": [ "p53" ], "offsets": [ [ 145, 148 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] } ]
[]
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1.0alpha7.train.1171
38469
[ { "id": "1.0alpha7.train.1171.sent", "type": "sentence", "text": [ "Therefore, we developed an in vitro binding assay to quantitate the effect of the Asp replacement of Ser on the binding of CREB to CBP." ], "offsets": [ [ 0, 143 ] ] } ]
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[]
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1.0alpha7.train.1172
18872872
[ { "id": "1.0alpha7.train.1172.sent", "type": "sentence", "text": [ "Gel mobility shift analysis of nuclear proteins bound to E1." ], "offsets": [ [ 0, 62 ] ] } ]
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[]
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[]
1.0alpha7.train.1173
4574093
[ { "id": "1.0alpha7.train.1173.sent", "type": "sentence", "text": [ "N-terminal Amino Acids 179–199 of dSPRY Bind to the Ring Finger Domain of dCbl" ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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1.0alpha7.train.1175
9541514
[ { "id": "1.0alpha7.train.1175.sent", "type": "sentence", "text": [ "We show here, both in vivo and in vitro, that GSK-3 cannot bind GBP and Axin simultaneously, leading to the model that GBP functions in part to prevent GSK-3 binding to the Axin/ APC/ beta-catenin complex." ], "offsets": [ [ 0, 211 ] ] } ]
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[]
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1.0alpha7.train.1176
15500143
[ { "id": "1.0alpha7.train.1176.sent", "type": "sentence", "text": [ "The immunoprecipitation analysis of DER demonstrated that Aos binds to DER in living DER/ S2 cells (Fig. 2A)." ], "offsets": [ [ 0, 114 ] ] } ]
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[]
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1.0alpha7.train.1177
15178762
[ { "id": "1.0alpha7.train.1177.sent", "type": "sentence", "text": [ "The C-terminal domain of SAF-A also contains the RGG-box, involved in binding to RNA ( 35), suggesting that RNA and p300 binding to SAF-A are mutually exclusive." ], "offsets": [ [ 0, 166 ] ] } ]
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[]
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1.0alpha7.train.1178
17968330
[ { "id": "1.0alpha7.train.1178.sent", "type": "sentence", "text": [ "Tropomyosins are well-characterized components of actin filaments that bind directly to F-actin and have distinct functions in muscle, where they are involved in the calcium-dependent regulation of muscle contraction, and in fibroblasts, where they are constituents of actin filament structures with undefined functions (Lees-Miller and Helfman, 1991). " ], "offsets": [ [ 0, 353 ] ] } ]
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[]
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1.0alpha7.train.1179
22650104
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[]
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[]
1.0alpha7.train.1180
11977662
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[]
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1.0alpha7.train.1181
9000366
[ { "id": "1.0alpha7.train.1181.sent", "type": "sentence", "text": [ "One explanation is that SOG binding to DPP in ventral-lateral regions could assist in forming a peak of DPP activity if DPP was carried some distance dorsally by SOG diffusion before being released by TLD action (Holley et al., 1996 )." ], "offsets": [ [ 0, 246 ] ] } ]
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[]
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1.0alpha7.train.1182
24655471
[ { "id": "1.0alpha7.train.1182.sent", "type": "sentence", "text": [ "Our results with ActRII trunc and those for activin, BMP2, and ActRII referenced above indicate that activin and BMP7 bind ActRII through a common interface." ], "offsets": [ [ 0, 164 ] ] } ]
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[]
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1.0alpha7.train.1183
4020748
[ { "id": "1.0alpha7.train.1183.sent", "type": "sentence", "text": [ "Binding of NF1 to the Sp1-mutated labeled probe was monitored by EMSA as in Fig. 2." ], "offsets": [ [ 0, 86 ] ] } ]
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[]
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