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DerNervenarzt.80690892.eng.abstr
DerNervenarzt.80690892.eng.abstr
[ { "id": "DerNervenarzt.80690892.eng.abstr-passage-0", "type": "abstract", "text": [ "We present a patient with Bickerstaff's brainstem encephalitis in whom MR imaging correlated with the clinical findings during the course of the disease . T2-weighted MR imaging showed increased signal intensity in the medulla oblongata , upper pons , pendunculi cerebelli and the cerebellum . In the course of the disease the lesions on MRI tended to descend more caudally . No anti-GQ1b antibody titers could be detected in the acute phase of the illness . Our findings suggest that MRI is the most valuable diagnostic tool in supporting the clinical diagnosis of Bickerstaff's brainstem encephalitis and may be helpful in the distinction between Miller Fisher syndrome and Bickerstaff's brainstem encephalitis ." ], "offsets": [ [ 0, 714 ] ] } ]
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"umlsterm", "text": [ "findings" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 145, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "imaging" ], "offsets": [ [ 170, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011923" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "medulla" ], "offsets": [ [ 219, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001629" }, { "db_name": "UMLS", "db_id": "C0025148" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pons" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032639" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "cerebellum" ], "offsets": [ [ 281, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153640" }, { "db_name": "UMLS", "db_id": "C0007765" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "medulla oblongata" ], "offsets": [ [ 219, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025148" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 315, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "MRI" ], "offsets": [ [ 338, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "antibody" ], "offsets": [ [ 389, 397 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 463, 471 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "MRI" ], "offsets": [ [ 485, 488 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 510, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 553, 562 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "Bickerstaff's" ], "offsets": [ [ 566, 579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0605770" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "brainstem" ], "offsets": [ [ 580, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "encephalitis" ], "offsets": [ [ 590, 602 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014038" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t8", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 663, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t9", "type": "umlsterm", "text": [ "Bickerstaff's" ], "offsets": [ [ 676, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0605770" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t10", "type": "umlsterm", "text": [ "brainstem" ], "offsets": [ [ 690, 699 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t11", "type": "umlsterm", "text": [ "encephalitis" ], "offsets": [ [ 700, 712 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014038" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t12", "type": "umlsterm", "text": [ "Fisher syndrome" ], "offsets": [ [ 656, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0393799" } ] }, { "id": "DerNervenarzt.80690892.eng.abstr-s5-t13", "type": "umlsterm", "text": [ "Miller Fisher syndrome" ], "offsets": [ [ 649, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0393799" } ] } ]
[]
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DerNervenarzt.80690896.eng.abstr
DerNervenarzt.80690896.eng.abstr
[ { "id": "DerNervenarzt.80690896.eng.abstr-passage-0", "type": "abstract", "text": [ "The intracranial space is divided into two large compartments by the tentorium . The hydrostatic pressure of spinal fluid is responsible for buoyancy of the brain within these compartments . In patients with craniectomy this equilibrium is exposed to atmospheric pressure . We report on four cases of reversible herniation after either bilateral or unilateral decompressive craniectomy performed for increased intracranial pressure ( ICP ) and failure of conservative ICP treatment . All four patients had survived a severe neurological disease ( encephalitis , subdural haematoma , stroke ) which required craniectomy to control raised ICP . All were successfully weaned from the ventilator and awake and CT scans showed no space-occupying lesion anymore . The patients showed a typical \" sunken pattern \" at the trepanation site . All patients developed clinical signs of transtentorial herniation ( i.e. unilateral dilated pupils , deteriorated alertness , and extensor posturing ) shortly after either diagnostic or presumed therapeutic lumbar puncture . One patient developed herniation a second time while in the typical 30 ° upright position . After craniectomy , transtentorial herniation is possible even in the absence of increased ICP . It is related to a negative gradient between atmospheric and intracranial pressure , which is enhanced by changes in the CSF compartment following lumbar puncture . Lumbar puncture should be avoided if possible and , when necessary , only be performed in the head-down position . Acute therapy in these cases is quite simple ; it requires flat or even head-down positioning and early cranioplasty ." ], "offsets": [ [ 0, 1646 ] ] } ]
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[]
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DerNervenarzt.80690901.eng.abstr
DerNervenarzt.80690901.eng.abstr
[ { "id": "DerNervenarzt.80690901.eng.abstr-passage-0", "type": "abstract", "text": [ "This case report intends to focus attention on hemodynamic TIAs as cause of repetitive involuntary movements ( RIMs ) as differential diagnosis of simple partial motor seizures . We report two patients with episodic unilateral limb shaking lasting up to several minutes and which could be triggered by orthostasis , heat or physical exertion . Repeated EEG recordings revealed no epileptic discharges . In both patients , duplex ultrasonography revealed an occlusion of the internal carotid artery ( ICA ) contralateral to the side of the RIMs . Blood flow velocities in the middle cerebral artery ipsilateral to ICA occlusion were reduced and vasomotor reactivity to hypercapnia was absent . After elevation of blood pressure both patients became asymptomatic . We suggest that in patients with episodes of RIMs , Doppler sonography and tests of cerebral vascular reserve capacity should be performed to search for a hemodynamic origin of these symptoms ." ], "offsets": [ [ 0, 956 ] ] } ]
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[]
[]
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"DerNervenarzt.80690901.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerNervenarzt.80690901.eng.abstr-s7-r5-t1.1-t2.1", "type": "performs", "arg1_id": "DerNervenarzt.80690901.eng.abstr-s7-t1", "arg2_id": "DerNervenarzt.80690901.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerNervenarzt.80690901.eng.abstr-s7-r6-t3.1-t6.1", "type": "treats", "arg1_id": "DerNervenarzt.80690901.eng.abstr-s7-t3", "arg2_id": "DerNervenarzt.80690901.eng.abstr-s7-t6", "normalized": [] } ]
DerNervenarzt.80690905.eng.abstr
DerNervenarzt.80690905.eng.abstr
[ { "id": "DerNervenarzt.80690905.eng.abstr-passage-0", "type": "abstract", "text": [ "Traditionally , intra-vitam diagnosis of fibromuscular dysplasia ( FMD ) of brain supplying arteries is a domain of conventional selective angiography . We are aware of only two publications reporting of ultrasound displayed intimal and medial variants of carotid artery FMD , in one case each . We present a patient in whom color-coded duplex-sonography revealed a web-like carotid artery bulb stenosis meeting the specific criteria of a subtype of intimal FMD ." ], "offsets": [ [ 0, 463 ] ] } ]
[ { "id": "DerNervenarzt.80690905.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 28, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 76, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "arteries" ], "offsets": [ [ 92, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "angiography" ], "offsets": [ [ 139, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002978" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 178, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 204, 214 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 264, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "carotid artery" ], "offsets": [ [ 256, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162859" }, { "db_name": "UMLS", "db_id": "C0007272" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 309, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 383, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 395, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 425, 433 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.80690905.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "carotid artery" ], "offsets": [ [ 375, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162859" }, { "db_name": "UMLS", "db_id": "C0007272" } ] } ]
[]
[]
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DerNervenarzt.80690913.eng.abstr
DerNervenarzt.80690913.eng.abstr
[ { "id": "DerNervenarzt.80690913.eng.abstr-passage-0", "type": "abstract", "text": [ "In 1988 , the first report on valproate in migraine prophylaxis was published . Since 1992 , 359 patients have been investigated in five double blind studies . Valproic acid was effective in all studies compared to placebo ; one study confirmed an effect similar to propranolol . There are no analyses of efficacy in comparison to plasma levels . Adverse events seem to occur somewhat more frequently than in propranolol , but are well known in epilepsy therapy . In the international literature and according to the recommendations of the German Headache Society , valproic acid is a well-established second-choice drug in migraine prophylaxis ." ], "offsets": [ [ 0, 646 ] ] } ]
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[]
[]
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"type": "interacts_with", "arg1_id": "DerNervenarzt.80690913.eng.abstr-s6-t6", "arg2_id": "DerNervenarzt.80690913.eng.abstr-s6-t5", "normalized": [] } ]
DerNervenarzt.80690924.eng.abstr
DerNervenarzt.80690924.eng.abstr
[ { "id": "DerNervenarzt.80690924.eng.abstr-passage-0", "type": "abstract", "text": [ "In patients with an acute cervicocephalic pain syndrome following whiplash injury ( n=12), pressure-pain scores for the splenius and the trapezius muscles on both sides , for the fingers on both sides and for the skull were recorded and compared to a control group . A computer-aided pain measurement was applied , which is presented as an improvement of pressure algesimetry . During constant application of pressure stimuli , the patient rated the increasing pain on a visual analogue scale , resulting in a curve of pain intensity against time . Slope and integral of the curve proved to be the most reliable parameters . After whiplash injury , significantly increased pain scores were found for the splenius muscle on both sides , for the left trapezius muscle and for the left finger whereas there was only a tendency of increased pain at the other stimulation sites . The presented method allows quantification of the cervical syndrome with neck and shoulder muscle sprain caused by whiplash injury . This objective and rater-independent method is of great value for diagnostic , therapeutic and medico-legal purposes in the assessment of the disease course and in clinical therapy trials ." ], "offsets": [ [ 0, 1197 ] ] } ]
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"DerNervenarzt.80690924.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "pressure-pain" ], "offsets": [ [ 91, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pressure-pain" ], "offsets": [ [ 91, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "muscles" ], "offsets": [ [ 147, 154 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "fingers" ], "offsets": [ [ 179, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016129" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "skull" ], "offsets": [ [ 213, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037303" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 251, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "pain syndrome" ], "offsets": [ [ 42, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0391976" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 66, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "control group" ], "offsets": [ [ 251, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009932" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 284, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerNervenarzt.80690924.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 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[]
[]
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DerNervenarzt.80690944.eng.abstr
DerNervenarzt.80690944.eng.abstr
[ { "id": "DerNervenarzt.80690944.eng.abstr-passage-0", "type": "abstract", "text": [ "Nearly all psychotropic drugs are metabolized by hepatic cytochrome P450-enzymes. In humans , there are 5 isoenzymes involved in this process . The activity of these enzymes can be modulated by a number of commonly used drugs , yielding potentially hazardous interactions . Most of the recently introduced selective serotonin reuptake inhibitors are potent inhibitors of cytochrome P450 enzymes . Thus , the plasma concentrations of tricyclic antidepressants or clozapine might be elevated into toxic levels . In contrast , carbamazepine induces most of the isoenzymes . This potentiates the elimination of tricyclics and antipsychotics and might cause a serious risk for the reccurence of depressive or psychotic symptoms . Moreover , 5-10% of the population are slow metabolizers of CYP2D6 . This group is prone to increased adverse effects of moderately dosed medication ." ], "offsets": [ [ 0, 875 ] ] } ]
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[]
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DerNervenarzt.80690956.eng.abstr
DerNervenarzt.80690956.eng.abstr
[ { "id": "DerNervenarzt.80690956.eng.abstr-passage-0", "type": "abstract", "text": [ "The present article endeavours an outline of depressive delusions , their symptomatology and their various topics . Their relations to depressive feelings of guilt and anxiety are discussed and defferentiated . Delusions of guilt , poverty or disease including their preliminary states are by no means rare but regularly occuring symptoms which substantiate the diagnosis of major depressive disorder/endogenous depression/melancholia . Preliminary states like hypochondriatic fears of guilt and poverty are likewise characteristic clinical signs which may be differentiated with high validity from the kind of anxiety associated to neurotic depression/dysthmia . Delusional depression did not prove to be a nosological entity but as a concept may bear considerable heuristic value concerning therapeutic considerations . This particularly serious form of depression requires specific therapeutic procedures ." ], "offsets": [ [ 0, 909 ] ] } ]
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[]
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DerNervenarzt.80690961.eng.abstr
DerNervenarzt.80690961.eng.abstr
[ { "id": "DerNervenarzt.80690961.eng.abstr-passage-0", "type": "abstract", "text": [ "In order to examine the efficacy of whole body acupuncture additionally applied to drug treatment in depression , a single-blind placebo-controlled study with 70 inpatients administered to three different treatment groups has been carried out . All patients were pharmacologically treated with the tetracyclic antidepressant mianserin . The verum group ( n=22) received acupuncture at specific points considered to be effective in the treatment of depression . The placebo group ( n=24) was treated with acupuncture at non-specific locations and the control group ( n=24) received only pharmacological treatment . Acupuncture was applied three times a week over a period of four weeks . Psychopathology was rated by judges blind to verum/placebo conditions twice a week over eight weeks with the CGI , GAS , BRMS and BfS rating scales . Additionally applied acupuncture improved the course of depression more than pharmacological treatment with mianserin did by itself . However , we could not detect any differences between placebo and verum acupuncture ." ], "offsets": [ [ 0, 1056 ] ] } ]
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"DerNervenarzt.80690961.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "antidepressant" ], "offsets": [ [ 310, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003289" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "mianserin" ], "offsets": [ [ 325, 334 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004388" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 370, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 435, 444 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 448, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": 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"DerNervenarzt.80690961.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Acupuncture" ], "offsets": [ [ 614, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 644, 649 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 664, 670 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "Psychopathology" ], "offsets": [ [ 687, 702 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033927" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "blind" ], "offsets": [ [ 723, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "DerNervenarzt.80690961.eng.abstr-s6-t3", "type": "umlsterm", 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[]
[]
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DerNervenarzt.80690968.eng.abstr
DerNervenarzt.80690968.eng.abstr
[ { "id": "DerNervenarzt.80690968.eng.abstr-passage-0", "type": "abstract", "text": [ "A number of observations including clinical manifestation , course , outcome , and family history , support the view that patients presenting with a major depression occurring first in late life should be treated as a nosological subgroup . In this study quantitative magnetic resonance imaging ( MRI ) was used to investigate volumes of different brain structures in 19 patients with late onset major depression ( age of onset > 50 ) and 13 age matched controls . 3-D MRI sequences were acquired using a Siemens 1.5T scanner . Whole brain volume , CSF volume , volume of the frontal and temporal lobes and the volume of the amygdala-hippocampus complex were assessed using the software NMRWin . Compared to the controls , depressed patients showed a significantly lower whole brain volume and a significantly higher CSF volume , whereas volumes of the frontal and temporal lobes as well as the amygdala-hippocampus complex volumes were not significantly decreased . In addition , depressed patients exhibited a higher ventricle-brain ratio suggesting a higher degree of central atrophy compared to healthy individuals . Our results indicate that cerebral changes involving subcortical structures are of relevance in the pathogenesis of late-onset depression . Defining the aetiology of these lesions may be important for the development of preventive treatment of depression in the elderly ." ], "offsets": [ [ 0, 1392 ] ] } ]
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DerNervenarzt.80690975.eng.abstr
DerNervenarzt.80690975.eng.abstr
[ { "id": "DerNervenarzt.80690975.eng.abstr-passage-0", "type": "abstract", "text": [ "The term \" mild cognitive impairment \" refers to cognitive deficits which exceed normal physiological aging processes , but do not fulfill the criteria for dementia . The prevalence rates of four current concepts were compared in a sample of 202 healthy 60-64 year-old participants recruited from the interdisciplinary longitudinal study on adult development and aging ( ILSE ) . Furthermore , the relationships between cognitive deficits and psychological and sociodemographic variables were examined . The following prevalence rates were determined : 13.5% for age-associated memory impairment , 6.5% for age-consistent memory impairment , 1.5% for late-life forgetfulness and 23.5% for aging-associated cognitive decline . Subjective cognitive complaints did not correlate with results obtained from neuropsychological tests . Significant correlations were however found between subjective cognitive complaints and higher scores on depression and neuroticism scales . Significant correlations were also found between a reduced test performance and a lower educational level and socioeconomic status . Longitudinal studies are warranted to further elucidate the predictive value of these diagnostic concepts ." ], "offsets": [ [ 0, 1211 ] ] } ]
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[]
[]
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DerNervenarzt.80690983.eng.abstr
DerNervenarzt.80690983.eng.abstr
[ { "id": "DerNervenarzt.80690983.eng.abstr-passage-0", "type": "abstract", "text": [ "Dementia-screening in clinical routine requires short , sensitive and specific tools . A number of standardized instruments are available for this purpose . The present study analysed the relationship between size of three examplary dementia-screening tests and their diagnostic accuracy ." ], "offsets": [ [ 0, 289 ] ] } ]
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[]
[]
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DerNervenarzt.80690991.eng.abstr
DerNervenarzt.80690991.eng.abstr
[ { "id": "DerNervenarzt.80690991.eng.abstr-passage-0", "type": "abstract", "text": [ "In this study we assessed the drawing abilities in 37 patients with probable Alzheimer's disease according to NINCDS-ADRDA criteria . Drawing abilities ( drawing : house , flower , clock ; Rey-Osterrieth figure ; copying : MMST-figure ; Rey-Osterrieth figure ) were quantified with different rating schemes and related to other neuropsychological assessments . All patients underwent a positron emission tomography with 18-FDG . Drawing performance was highly correlated with severity of dementia - expressed in MMST scores ( r=0.78; p 0.0001 ) - with visuo-spatial short-term memory ( r=-0.69; p=0.001), and writing abilities ( r=-0.77; p 0.0001 ) . The summarized drawing score showed a statistically significant correlation with the rate of temporoparietal glucose metabolism measured with positron emission tomography and 18-FDG ( r=0.39; p=0.017). In the drawings of AD patients omittings and simplifications were typical , whereas perseverations rarely occured . In severely demented patients closing-in phenomenons could be de- scribed , too . A subgroup of AD patients with visuo-constructive impairment as the leading symptom could not be identified ." ], "offsets": [ [ 0, 1160 ] ] } ]
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[]
[]
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DerNervenarzt.80691007.eng.abstr
DerNervenarzt.80691007.eng.abstr
[ { "id": "DerNervenarzt.80691007.eng.abstr-passage-0", "type": "abstract", "text": [ "The use of the Kaufman-Assessment Battery for Children ( K-ABC ) was evaluated with a sample of 50 mentally disabled adults in a wide age range , as there exist no special tests for this group of patients . Intercorrelation- and factor analyses , and correlations with the German adaptation of the Wechsler Adult Intelligence Scale ( HAWIE-R ) proved the use of the K-ABC to be valid . As an assessment battery for children designed for the wide age range from 2-6 to 12-5 years is more adequate to the capability of intellectually impaired adults , the K-ABC delivers results on individual strengths and weaknesses , based on a neuropsychological theory . Thus the individual cognitive abilities can be assessed with more differentiation , and that gives an important base for intervention , partial remediation , and placement ." ], "offsets": [ [ 0, 830 ] ] } ]
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DerNervenarzt.80691019.eng.abstr
DerNervenarzt.80691019.eng.abstr
[ { "id": "DerNervenarzt.80691019.eng.abstr-passage-0", "type": "abstract", "text": [ "The following review summarizes current knowledge on the treatment of therapy-resistant patients with affective disorders with supraphysiological doses of thyroxine ( T4). Several groups have reported independently of each other that administration of 200-500 µg T4/day has excellent effects in 50-65% of patients a ) with bipolar disorder , with or without \" rapid cycling \" course , who were previously resistant to all prophylactic drugs and b ) in the treatment of therapy-resistant depression . T4 is effective only in combination with an antidepressant or a prophylactic drug . Side effects are minimal , even when T4 is administered over several years . These results now justify to recommend high dose T4-augmentation as \" last-resort \" treatment also beyond research purposes , i . e . in psychiatric wards and in private practice . Recommendations for clinical applications are given and hypotheses on possible mechanisms underlying the efficacy of T4 treatment are discussed ." ], "offsets": [ [ 0, 987 ] ] } ]
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[]
[]
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DerNervenarzt.80691029.eng.abstr
DerNervenarzt.80691029.eng.abstr
[ { "id": "DerNervenarzt.80691029.eng.abstr-passage-0", "type": "abstract", "text": [ "With the recent developments in computer technology and the improvements in modern neuroimaging , frame-based stereotactic guidance for open microsurgical procedures has been increasingly replaced by neuronavigation , also called frameless stereotaxy . It allows transfer of individual patient's images onto the operative field to assist the neurosurgeon intraoperatively in defining the tumor margins or identifying functionally important brain areas . The different localization techniques employed are articulated position-sensing arms , infrared or ultrasound systems working with the principle of satellite navigation and robotic systems integrated with the operating microscope . In 200 operations performed with different systems ( arm-based , robotic and infrared ) the method proved to be helpful , enabling fewer invasive procedures to be performed . With a mean deviation of 2.87 +/- 1.9 mm for intraoperative localization , the accuracy was only slightly worse than in frame-based stereotaxy with deviations below 2 mm . Neuronavigation was most helpful for operations on deeply seated lesions , skull-base tumors and lesions in brain areas with high functionality . The major disadvantage is the use of preoperative data for navigation , leading to inaccuracies when anatomical structures are altered during the operation by resection of tumors or shift of intracranial soft tissue . Intraoperative magnetic resonance imaging ( MRI ) might be a solution for this problem . With the method of intraoperative MRI developed in our department it has already been possible to update neuronavigation with images reflecting intraoperative changes in anatomy . Therefore , neuronavigation is definitely a method with growing importance in operative routine , and it will also spread into other surgical specialties ." ], "offsets": [ [ 0, 1821 ] ] } ]
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[ { "id": "DerNervenarzt.80691037.eng.abstr-passage-0", "type": "abstract", "text": [ "For a large number of patients with stroke no therapeutic option can be offered , even after approval of thrombolytic therapy for treatment of acute ischemic stroke in the US . In cerebral ischemia local anoxia and energy failure lead to further cellular damage and finally to complete stroke . All therapeutic concepts try to salvage structurally intact tissue which is at risk for irreversible damage ( so-called penumbra ) . Hyperbaric oxygen ( HBO ) treatment has been reported in animal models of cerebral ischemia , and in a few clinical reports . In general , the results of these studies have been promising . This review focuses on the clinical perspective of HBO therapy and summarizes both the clinical and experimental data availabe on HBO therapy following ischemic stroke ." ], "offsets": [ [ 0, 787 ] ] } ]
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DerNervenarzt.80691045.eng.abstr
DerNervenarzt.80691045.eng.abstr
[ { "id": "DerNervenarzt.80691045.eng.abstr-passage-0", "type": "abstract", "text": [ "To date , positron emission tomography ( PET ) is the most powerful method for the in-vivo investigation of human brain metabolism . Besides extensive application of this technology in the neurosciences , PET is also being increasingly used as a clinical tool . However , despite its acceptance in clinical practice , a major obstacle is its high costs . The present article reviews the literature on the clinical use of PET in neurology , neurosurgery , and psychiatry in order to substantiate the clinical indications for PET in these specialties as established by an interdisciplinary conference ." ], "offsets": [ [ 0, 600 ] ] } ]
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[]
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"DerNervenarzt.80691045.eng.abstr-s4-t3", "arg2_id": "DerNervenarzt.80691045.eng.abstr-s4-t6", "normalized": [] }, { "id": "DerNervenarzt.80691045.eng.abstr-s4-r33-t1.1-t5.1", "type": "issue_in", "arg1_id": "DerNervenarzt.80691045.eng.abstr-s4-t1", "arg2_id": "DerNervenarzt.80691045.eng.abstr-s4-t5", "normalized": [] }, { "id": "DerNervenarzt.80691045.eng.abstr-s4-r34-t3.1-t5.1", "type": "issue_in", "arg1_id": "DerNervenarzt.80691045.eng.abstr-s4-t3", "arg2_id": "DerNervenarzt.80691045.eng.abstr-s4-t5", "normalized": [] } ]
DerNervenarzt.80691061.eng.abstr
DerNervenarzt.80691061.eng.abstr
[ { "id": "DerNervenarzt.80691061.eng.abstr-passage-0", "type": "abstract", "text": [ "Purpose : Course and pathophysiology of a typical syndrome after irradiation of the cauda equina were studied ." ], "offsets": [ [ 0, 111 ] ] } ]
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[]
[]
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DerNervenarzt.80691066.eng.abstr
DerNervenarzt.80691066.eng.abstr
[ { "id": "DerNervenarzt.80691066.eng.abstr-passage-0", "type": "abstract", "text": [ "Upper limb ataxia is one of the most disabling symptoms of patients with multiple sclerosis ( MS ) . There are some clinically tested therapeutic strategies , especially with regard to cerebellar tremor . But most of the methods used for treatment of limb ataxia in physiotherapy and occupational therapy are not systematically evaluated , e.g. the effect of local ice applications , as reported by MS patients and therapists , respectively ." ], "offsets": [ [ 0, 442 ] ] } ]
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[]
[]
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DerNervenarzt.80691074.eng.abstr
DerNervenarzt.80691074.eng.abstr
[ { "id": "DerNervenarzt.80691074.eng.abstr-passage-0", "type": "abstract", "text": [ "Almost all patients with amyotrophic lateral sclerosis ( ALS ) experience symptoms of nocturnal hypoventilation during the course of the illness . These symptoms can develop years before death and may severely affect quality of life . Non-invasive intermittent home mechanical ventilation ( HMV ) via mask is a possible palliative measure for these symptoms , which is not often used in Germany . We report on our experience with HMV in 24 patients with ALS . Our data show a good palliative effect in 17 of 24 treated patients . Severe complications did not occur . The mean ventilation time at present is 14 months . Available options and their consequences need to be discussed in detail with patients and relatives before HMV is initiated ." ], "offsets": [ [ 0, 744 ] ] } ]
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[]
[]
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"DerNervenarzt.80691074.eng.abstr-s8-t1", "arg2_id": "DerNervenarzt.80691074.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerNervenarzt.80691074.eng.abstr-s7-r2-t1.2-t2.1", "type": "occurs_in", "arg1_id": "DerNervenarzt.80691074.eng.abstr-s7-t1", "arg2_id": "DerNervenarzt.80691074.eng.abstr-s8-t2", "normalized": [] }, { "id": "DerNervenarzt.80691074.eng.abstr-s7-r3-t1.2-t1.1", "type": "result_of", "arg1_id": "DerNervenarzt.80691074.eng.abstr-s7-t1", "arg2_id": "DerNervenarzt.80691074.eng.abstr-s8-t1", "normalized": [] }, { "id": "DerNervenarzt.80691074.eng.abstr-s8-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerNervenarzt.80691074.eng.abstr-s8-t1", "arg2_id": "DerNervenarzt.80691074.eng.abstr-s8-t2", "normalized": [] }, { "id": "DerNervenarzt.80691074.eng.abstr-s8-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerNervenarzt.80691074.eng.abstr-s8-t2", "arg2_id": "DerNervenarzt.80691074.eng.abstr-s8-t1", "normalized": [] } ]
DerNervenarzt.80691083.eng.abstr
DerNervenarzt.80691083.eng.abstr
[ { "id": "DerNervenarzt.80691083.eng.abstr-passage-0", "type": "abstract", "text": [ "Retrospective examination of 44 patients with central pontine and/or extrapontine myelinolysis leads to the conclusion that in early diagnostics cerebral NMR is superior to cCT . T2-weighted images turned out to be the most sensitive parameter . Frequent contrast-medium enhancement early in the course up to 4 weeks after clinical manifestation in 7 patients underlines the pathogenetic idea of an initial transient blood-brain barrier . According to our results , central-pontine myelinolysis ( CPM ) proof by NMR can be expected after 1 week . During the clinical course , cCT and NMR findings showed no regression . Also no connection was noted between the size of the pontine lesion and the favorable clinical course in 72.2% of the patients , nor was there a correlation with the extent of the neurological symptoms at the crisis of the disease . Altogether , cCT and NMR are irrelevant for the prognosis of cerebral myelinolysis ." ], "offsets": [ [ 0, 937 ] ] } ]
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[]
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DerNervenarzt.80691107.eng.abstr
DerNervenarzt.80691107.eng.abstr
[ { "id": "DerNervenarzt.80691107.eng.abstr-passage-0", "type": "abstract", "text": [ "Lesions detected in the white matter by T2-weighted MRI are often inadvertently attributed to multiple sclerosis ( MS ) ." ], "offsets": [ [ 0, 121 ] ] } ]
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[]
[]
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DerNervenarzt.80691111.eng.abstr
DerNervenarzt.80691111.eng.abstr
[ { "id": "DerNervenarzt.80691111.eng.abstr-passage-0", "type": "abstract", "text": [ "Tics-disorders are hyperkinetic movement disorders which manifest in childhood or early adolescence and ameliorate in later adulthood . We report on two patients with a basically subclinical tic-disorder ( age of 53 and 68 years ) . During the therapy of polymyalgia rheumatica and endocrine orbitopathy in Graves disease with prednisolone the tics exacerbated and were therefore diagnosed and treated for the first time . Possible causes for the exacerbation of the tics during the therapy with glucocorticosteroids are discussed in the context of the dopamine hypothesis of tics ." ], "offsets": [ [ 0, 582 ] ] } ]
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[]
[]
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DerNervenarzt.80691115.eng.abstr
DerNervenarzt.80691115.eng.abstr
[ { "id": "DerNervenarzt.80691115.eng.abstr-passage-0", "type": "abstract", "text": [ "Recurrent transverse myelitis is a rare inflammatory demyelinating disorder , which is distinguished from acute monophasic transverse myelitis and from MS . We present two patients with recurrent transverse myelitis , who developed an acute remitting tetraparesis and sensible deficits with a cervical level . They were followed for 4 and 5 years . MRI showed an isolated lesion with contrast enhancement in the spinal cord but no pathological cranial findings . Oligoclonal bands were negative in repeated lumbar punctures . One patient showed lymphocytic pleocytosis during the first and second attack . Somatosensory and motor evoked potentials were abnormal during relapses while visually and brainstem acustically evoked potentials ( VEP and BAEP ) stayed within limits . Laboratory examinations for bacterial , viral or parasitic infections , antinuclear antibodies , Angiotensin-converting enzyme and the sedimentation rate were also normal ." ], "offsets": [ [ 0, 949 ] ] } ]
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"DerNervenarzt.80691115.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "transverse myelitis" ], "offsets": [ [ 123, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026976" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 172, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "myelitis" ], "offsets": [ [ 207, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026975" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "tetraparesis" ], "offsets": [ [ 251, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0270790" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "transverse myelitis" ], "offsets": [ [ 196, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026976" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "MRI" ], "offsets": [ [ 349, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 384, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 452, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "spinal cord" ], "offsets": [ [ 412, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153646" }, { "db_name": "UMLS", "db_id": "C0037925" }, { "db_name": "UMLS", "db_id": "C0154034" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "punctures" ], "offsets": [ [ 514, 523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034117" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "Oligoclonal bands" ], "offsets": [ [ 463, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0133820" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "lumbar punctures" ], "offsets": [ [ 507, 523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037943" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 530, 537 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "pleocytosis" ], "offsets": [ [ 557, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151857" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "relapses" ], "offsets": [ [ 669, 677 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035020" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "brainstem" ], "offsets": [ [ 697, 706 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "evoked potentials" ], "offsets": [ [ 630, 647 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015214" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "evoked potentials" ], "offsets": [ [ 719, 736 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015214" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "motor evoked potentials" ], "offsets": [ [ 624, 647 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282617" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "Laboratory" ], "offsets": [ [ 777, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "bacterial" ], "offsets": [ [ 805, 814 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "viral" ], "offsets": [ [ 817, 822 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521026" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "parasitic" ], "offsets": [ [ 826, 835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521066" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 836, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 861, 871 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerNervenarzt.80691115.eng.abstr-s8-t7", "type": "umlsterm", 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[]
[]
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DerNervenarzt.80691123.eng.abstr
DerNervenarzt.80691123.eng.abstr
[ { "id": "DerNervenarzt.80691123.eng.abstr-passage-0", "type": "abstract", "text": [ "In 1994 this journal published the results of a survey undertaken on behalf of the Working Association for Neurological Intensive Care Medicine ( ANIM ) in the winter of 1992/93 . In the winter of 1996/97 a continuation of this analysis was performed . With the help of a questionaire the data of 62 intensive care units with a total of 420 beds were established . This is 11 intensive care units and 83 beds more than 1992/93 . The intensive care units were again classified into three groups ( ventilation units , monitoring units , interdisciplinary units ) relating to their equipment and structure . The questions concerned structural organisation , such as the number of beds , type of clinic , number and training of physicians and nurses , technical equipment and availability of large and high-tech apparatus or access to other facilities , such as neurosurgery . Of great interest were data about whether and to what extent special measures of intensive medicine can be taken on the one hand and performance parameter data e.g. days of ventilation and duration of in-patient treatment on the other hand . Detailed data were provided concerning the frequency of each diagnosis of patients treated in those intensive care units . Evaluating the data a positive development in the last four years of the neurological intensive care can be found in most of the areas investigated . It has also been found that neurological intensive care in the new lander has reached equal standard both in quality and quantity . Now a single physician is responsible for 2,3 beds compared to 3,6 . Today 78 per cent of the beds in ventilation units are equiped with a ventilator . The overall time of ventilation increased to 48 per cent . Overall there are , however , considerable differences between individual units as well as regions . The data presented can serve as a means to monitor the quality of neurological intensive care ." ], "offsets": [ [ 0, 1927 ] ] } ]
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DerNervenarzt.90700001.eng.abstr
DerNervenarzt.90700001.eng.abstr
[ { "id": "DerNervenarzt.90700001.eng.abstr-passage-0", "type": "abstract", "text": [ "In children and adolescents motor/vocal tics and obsessive-compulsive behavior are known to be closely related . Thereby , a continuum of symptoms ranging from single tics to a mixed picture of tics/rituals/obsessive-compulsive traits to clinically relevant obsessions and compulsions could be described . As neurobiological substrates dysfunctions in corresponding cortico-striato-thalamo-cortical circuits ( sensorimotor circuit in tic symptomatology , orbitofrontal circuit in obsessive-compulsive behavior ) were postulated . For both disturbances behavioral therapy can be used to improve control mechanisms to counterregulate tics and obsessive-compulsive behavior , respectively , and psychopharmacological agents can be administerd to compensate dysbalances in neurotransmitter systems . In case of a mixed symptomatologic picture it is necessary to include interventions for both pols of the symptom-continuum in the therapeutic programme to achieve extensive improvement as a basis for a further positive development of the patient ." ], "offsets": [ [ 0, 1043 ] ] } ]
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DerNervenarzt.90700011.eng.abstr
DerNervenarzt.90700011.eng.abstr
[ { "id": "DerNervenarzt.90700011.eng.abstr-passage-0", "type": "abstract", "text": [ "For the treatment of obsessive-compulsive disorders during childhood and adolescence , multidimensional therapeutical approaches have proven useful in clinical practice . First controlled studies have demonstrated the efficacy of both psychotherapeutical and pharmacological strategies . Exposure and response prevention are considered the most efficient psychotherapeutical methods . On the basis of the available data , the question of the pharmacological dose can not be answered definitely . For Clomipramin , the dose most probably is between 75 mg and 150 mg , where as for Fluoxetine and Fluvoxamine 20mg-60 mg and 100mg-250 mg respectively . However , it has to be kept in mind that sometimes improvement of symptoms is not seen after 8-10 weeks of treatment . Basically it can be stated that todate there is an urgent need for therapeutical studies of obsessive-compulsive disorders in the childhood and adolescence . Most relevant would be studies evaluating pharmacological treatment versus a placebo control groups and carefully designed controlled psychotherapeutical treatment studies as well studies comparing pharmacological and psychotherapeutical approaches ." ], "offsets": [ [ 0, 1177 ] ] } ]
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[]
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DerNervenarzt.90700020.eng.abstr
DerNervenarzt.90700020.eng.abstr
[ { "id": "DerNervenarzt.90700020.eng.abstr-passage-0", "type": "abstract", "text": [ "The attention-deficit hyperactivity disorder ( ADHD ) is one of the most common disorders in childhood and adolescence with a prevalence of app . 5% . The importance of ADHD in childhood as a factor of vulnerability for psychiatric disorders in adults is becoming a focus of discussion . It was shown that there is a comorbidity in adults with substance abuse , delinquency and personality disorders . There is a growing evidence that ADHD will persist in a significant number of patients during adulthood ." ], "offsets": [ [ 0, 507 ] ] } ]
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[]
[]
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DerNervenarzt.90700026.eng.abstr
DerNervenarzt.90700026.eng.abstr
[ { "id": "DerNervenarzt.90700026.eng.abstr-passage-0", "type": "abstract", "text": [ "The symptomatology of a female patient with catatonic schizophrenia is presented with respect to its longitudinal course . The stability and variability of catatonic symptoms are investigated using videotape technique . It is demonstrated that catatonic symptoms are stable in the longitudinal course but due to unsteady arousal they severity of the catatonic symptoms varies markedly . There are fluctuating symptom patterns that dominate the clinical picture : a hyperkinetic form with prevailing restlessness or excitement , with abnormal involuntary movements , stereotypies , and parakinetic movements , and a hypokinetic form with various inhibition phenomena , mutism and stupor . The clinical impression of the catatonic syndrome changes according to the dominating symptom patterns at different times , whereas the less severe symptoms recede into the background and thus , may be overlooked . Considering this finding the problem of a ' diagnostic threshold ' is discussed . The authors intend to emphasize videotape documentation of catatonic motor disturbances as most useful . This technique may contribute to differentiating illness related from neuroleptic induced movement disorders ." ], "offsets": [ [ 0, 1200 ] ] } ]
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[]
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DerNervenarzt.90700031.eng.abstr
DerNervenarzt.90700031.eng.abstr
[ { "id": "DerNervenarzt.90700031.eng.abstr-passage-0", "type": "abstract", "text": [ "Underweight is a key symptom in anorexia nervosa . In this review we summarize recent findings pertaining to weight regulation in this eating disorder . The observation that a body mass index below 13 kg/m2 upon admission for inpatient treatment is associated with a high mortality rate and chronic persistence of underweight is of obvious clinical relevance . A lowered leptin secretion , which results from the weight loss , is presumably of major importance for the development of amenorrhea . We discuss findings pertaining to a reduced body weight in other psychiatric disorders during adolescence in the light of Kretschmer's findings related to body frame and psychopathology ." ], "offsets": [ [ 0, 684 ] ] } ]
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DerNervenarzt.90700064.eng.abstr
DerNervenarzt.90700064.eng.abstr
[ { "id": "DerNervenarzt.90700064.eng.abstr-passage-0", "type": "abstract", "text": [ "In the examination in question , the case history of a patient who had exhibited serious obsessive-compulsive symptoms since the age of 14 is described . It is not an independent obsessive-compulsive disorder , but a case of schizophrenia masked by obsessive-compulsive symptoms . During therapy for the schizophrenic symptoms with clozapine , which set in at the age of 31 , neither psychotic symptoms nor obsessive-compulsive symptoms worth mentioning can be found at the 1-year catamnesis . Whereas the literature increasingly points to obsessive-compulsive symptoms being a side-effect of clozapine medication , usually in the clinical indication area of chronic schizophrenic psychoses , as far as the author knows , this describes a rare case of improvement of obsessive-compulsive symptoms using clozapine after first suffering from a schizophrenic disorder . The meaning of differential diagnostics of obsessive-compulsive phenomena for adequate pharmacotherapy is discussed using the example of the individual case ." ], "offsets": [ [ 0, 1025 ] ] } ]
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DerNervenarzt.90700068.eng.abstr
DerNervenarzt.90700068.eng.abstr
[ { "id": "DerNervenarzt.90700068.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on the successful treatment of two female patients with psychotic depression with the new atypical neuroleptic drug olanzapine . A 75-year-old female inpatient suffering from recurrent endogenous depression with tactile hallucinations and coenesthesia was refractory to a systematic sequential antidepressant treatment strategy during a 39-week period . After addition of the new atypical neuroleptic olanzapine to the SSRI citalopram , she showed immediate and ongoing symptom relief . In the second case of a 57-year-old female inpatient suffering from delusional depression , we observed marked symptom relief and correction of the delusions of impoverishment . Olanzapine is discussed with regard to its receptor-binding profile ( antagonism to 5-HT2A- and D1-D4 receptors ) as a potential neuroleptic drug in the treatment of affective disorders with psychotic symptoms ." ], "offsets": [ [ 0, 886 ] ] } ]
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[]
[]
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DerNervenarzt.90700072.eng.abstr
DerNervenarzt.90700072.eng.abstr
[ { "id": "DerNervenarzt.90700072.eng.abstr-passage-0", "type": "abstract", "text": [ "With the introduction of the non-benzodiazepine hypnotics zopiclone and zolpidem it was expected to have hypnotics without side effects and risks characteristically seen with benzodiazepines . We report two cases with high-dose usage and dependency of non-benzodiazepine hypnotics . Both patients were prescribed the drugs to treat sleep disturbances occuring during a depressive episode . While one patient had a polysubstance abuse there was no evidence for an abuse history in the other patient . To reduce withdrawal symptoms long-acting benzodiazepines were given to both patients . Thus , it seems that not only patients with a history of substance abuse but also patients with a psychiatric disorder are at risk for abuse of non-benzodiazepine hypnotics . Considering the increasing number of case reports with abuse and dependence of zopiclone and zolpidem it seems necessary to reevaluate the dependency risk of the currently available non-benzodiazepine hypnotics ." ], "offsets": [ [ 0, 975 ] ] } ]
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[]
[]
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DerNervenarzt.90700076.eng.abstr
DerNervenarzt.90700076.eng.abstr
[ { "id": "DerNervenarzt.90700076.eng.abstr-passage-0", "type": "abstract", "text": [ "The Internet is a fast growing medium , which is about to alter our all day life . Most impact is given to advantages of telemedicine to psychiatrists and psychotherapists as well as patients . After introduction of the essential features of the Internet practical aspects of medicine in Cyberspace for psychotherapists , psychiatrists and their patients are shown . Then , the general prohibition of advertisement for physicians is discussed on the bases of actual laws related to Internet activities . Relevant resources of medical information are shown with regard to the detailed facilities of using searchengines . Highlighting opportunities and possible resources of medicine in cyberspace , it is made clear , that the rising interest in telemedicine on Internet is more than justified . Finally , some risks of virtual communication are visible . Important and mentioned Web-sites are listed at the end ." ], "offsets": [ [ 0, 912 ] ] } ]
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DerNervenarzt.90700089.eng.abstr
DerNervenarzt.90700089.eng.abstr
[ { "id": "DerNervenarzt.90700089.eng.abstr-passage-0", "type": "abstract", "text": [ "Recent progress in the field of molecular genetics revealed a broader spectrum of dystrophin-related disorders than previously assumed . In addition , the pathogenetic basis of other types of muscular dystrophies could be identified : some autosomal-recessive limb girdle dystrophies are caused by mutations of sarcoglycan genes , others are caused by deficiency of the sarcoplasmatic enzyme calpain-3. Emery-Dreifuss muscular dystrophy is due to the deficiency of the nuclear membrane protein emerin . About 50% of congenital muscular dystrophies are related to mutations of a extracellular matrix protein merosin ( -laminin ) . A series of monoclonal antibodies for immunohistochemistry is now available recognizing many cytoskeletal muscle proteins . In combination with molecular genetics a diagnostic flow chart can be developed which allows a definite diagnosis in most cases . In this review disease entities are illustrated by case reports . We discuss the significance of immunohistochemical and molecular methods for diagnosis ." ], "offsets": [ [ 0, 1038 ] ] } ]
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"DerNervenarzt.90700089.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mutations" ], "offsets": [ [ 298, 307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026882" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "genes" ], "offsets": [ [ 323, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "deficiency" ], "offsets": [ [ 352, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "enzyme" ], "offsets": [ [ 385, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" }, { "db_name": "UMLS", "db_id": "C0014445" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "deficiency" ], "offsets": [ [ 451, 461 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "membrane" ], "offsets": [ [ 477, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025255" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "protein" ], "offsets": [ [ 486, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "emerin" ], "offsets": [ [ 494, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0295734" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "muscular dystrophies" ], "offsets": [ [ 192, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026850" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "muscular dystrophy" ], "offsets": [ [ 418, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026850" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "nuclear membrane" ], "offsets": [ [ 469, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028584" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "membrane protein" ], "offsets": [ [ 477, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025252" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s2-t14", "type": "umlsterm", "text": [ "Emery-Dreifuss muscular dystrophy" ], "offsets": [ [ 403, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0410189" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "congenital" ], "offsets": [ [ 516, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009678" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "mutations" ], "offsets": [ [ 563, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026882" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "protein" ], "offsets": [ [ 599, 606 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "merosin" ], "offsets": [ [ 607, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376333" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "merosin" ], "offsets": [ [ 607, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0073589" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "-laminin" ], "offsets": [ [ 617, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022984" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "muscular dystrophies" ], "offsets": [ [ 527, 547 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026850" } ] }, { "id": "DerNervenarzt.90700089.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "extracellular matrix" ], "offsets": [ [ 578, 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[]
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DerNervenarzt.90700101.eng.abstr
DerNervenarzt.90700101.eng.abstr
[ { "id": "DerNervenarzt.90700101.eng.abstr-passage-0", "type": "abstract", "text": [ "Cerebral ischemia leads to a cascade of pathophysiological processes which contribute to ischemic cell damage . In addition to the excitotoxicity , which is characterized by a massively elevated extracellular concentration of excitatory amino acids and an intracellular overload with calcium , the increased formation of free radicals , the inflammation and the apoptosis are also involved in ischemic damage . Neuroprotection , a pharmacological interaction with these pathophysiological processes , is one possibility to attenuate the consequences of cerebral ischemia . In experimental studies it could be demonstrated that glutamate antagonists , calcium antagonists or radical scavengers reduce the ischemic damage . Substances which interact with inflammation or apoptosis have also been shown to be protective . Clinical trials , however , showed no beneficial effects . This discrepancy is mainly due to differences in the design of the studies . In experimental studies the substances were often applied before or at the onset of ischemia , the survival time after ischemia was very short and the effects of neuroprotection were mainly evaluated by morphological examinations . Considering these points in future preclinical studies it is hoped that neuroprotective substances will be found which may be effective in clinical trials ." ], "offsets": [ [ 0, 1343 ] ] } ]
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DerNervenarzt.90700111.eng.abstr
DerNervenarzt.90700111.eng.abstr
[ { "id": "DerNervenarzt.90700111.eng.abstr-passage-0", "type": "abstract", "text": [ "Six enzyme defects of the urea cycle have been described . Ornithine transcarbamylase deficiency is the most frequent of these diseases . The cumulative frequency is 1:8000 . Most patients become symptomatic in childhood , but onset of symptoms may occur later in childhood or even adulthood ." ], "offsets": [ [ 0, 293 ] ] } ]
[ { "id": "DerNervenarzt.90700111.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "enzyme" ], "offsets": [ [ 4, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" }, { "db_name": "UMLS", "db_id": "C0014445" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 11, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "urea" ], "offsets": [ [ 26, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041942" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Ornithine" ], "offsets": [ [ 59, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029277" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "deficiency" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 127, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Ornithine transcarbamylase" ], "offsets": [ [ 59, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029279" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "frequency" ], "offsets": [ [ 153, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376249" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 180, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 236, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] } ]
[]
[]
[ { "id": "DerNervenarzt.90700111.eng.abstr-s1-r1-t1.1-t1.2", "type": "issue_in", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s1-r2-t1.1-t1.2", "type": "interacts_with", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s1-r3-t2.1-t1.2", "type": "issue_in", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s1-r4-t1.2-t1.1", "type": "interacts_with", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s1-t1", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r1-t1.1-t2.1", "type": "affects", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r2-t2.1-t1.1", "type": "produces", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r3-t4.1-t1.1", "type": "interacts_with", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s2-t4", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r4-t2.1-t4.1", "type": "produces", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r5-t4.1-t2.1", "type": "affects", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s2-t4", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerNervenarzt.90700111.eng.abstr-s2-r6-t1.1-t4.1", "type": "interacts_with", "arg1_id": "DerNervenarzt.90700111.eng.abstr-s4-t1", "arg2_id": "DerNervenarzt.90700111.eng.abstr-s2-t4", "normalized": [] } ]
DerNervenarzt.90700119.eng.abstr
DerNervenarzt.90700119.eng.abstr
[ { "id": "DerNervenarzt.90700119.eng.abstr-passage-0", "type": "abstract", "text": [ "Tick-borne encephalitis ( TBE ) is the most severe arbovirus disease transmitted by ticks . The mortality of the central European form is 0.7-2%. Active immunisation is recommended for endemic regions . We report on 4 patients with TBE aquired in Middle-Hessen between 1994 and 1997 ( 2 in 1997 ) . After repeated CSF and serum testing the TBE-specific antibodies were found in all 4 cases . In one case there was also evidence for a prior infection with borrelia burgdorferi . The results of the initial CSF-analysis were atypical in 2 cases ( high cell count of 136 cells/mm3, total protein up to 1.5 g/l ) . The endemic region for TBE has expanded in northern direction into Middle-Hessen , a region in which Lyme borreliosis is also endemic . Thus , true double infections are possible . This and the initially frequently atypical CSF-findings make the differential diagnosis difficult . Therefore , repetitive CSF and blood examinations are recommended ." ], "offsets": [ [ 0, 959 ] ] } ]
[ { "id": "DerNervenarzt.90700119.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "encephalitis" ], "offsets": [ [ 11, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014038" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "arbovirus" ], "offsets": [ [ 51, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003725" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 61, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Tick-borne encephalitis" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014061" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "form" ], "offsets": [ [ 130, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "immunisation" ], "offsets": [ [ 153, 165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020971" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "endemic" ], "offsets": [ [ 185, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243130" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "Active immunisation" ], "offsets": [ [ 146, 165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205991" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 218, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "CSF" ], "offsets": [ [ 314, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 353, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 440, 449 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "borrelia" ], "offsets": [ [ 455, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006033" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "borrelia burgdorferi" ], "offsets": [ [ 455, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006034" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "CSF-analysis" ], "offsets": [ [ 505, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "CSF-analysis" ], "offsets": [ [ 505, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 550, 554 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "protein" ], "offsets": [ [ 585, 592 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "cell count" ], "offsets": [ [ 550, 560 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007584" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "endemic" ], "offsets": [ [ 615, 622 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243130" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "direction" ], "offsets": [ [ 663, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700158" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "borreliosis" ], "offsets": [ [ 717, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0751995" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "endemic" ], "offsets": [ [ 737, 744 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243130" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "Lyme borreliosis" ], "offsets": [ [ 712, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024198" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 766, 776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 870, 879 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "differential diagnosis" ], "offsets": [ [ 857, 879 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220820" }, { "db_name": "UMLS", "db_id": "C0011906" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "CSF" ], "offsets": [ [ 915, 918 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 923, 928 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] } ]
[]
[]
[ { "id": "DerNervenarzt.90700119.eng.abstr-s1-r1-t2.1-t4.1", "type": "causes", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-r2-t2.1-t1.1", "type": "causes", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-r3-t1.1-t2.1", "type": "affects", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-r4-t4.1-t2.1", "type": "affects", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s7-t4", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-r5-t2.1-t3.1", "type": "causes", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s1-r6-t3.1-t2.1", "type": "affects", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s7-t3", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-r1-t1.1-t4.1", "type": "isa", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-r2-t1.1-t2.1", "type": "conceptual_part_of", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-r3-t1.1-t5.1", "type": "conceptual_part_of", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s7-t5", "normalized": [] }, { "id": "DerNervenarzt.90700119.eng.abstr-s2-r4-t5.1-t2.1", "type": "uses", "arg1_id": 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"DerNervenarzt.90700119.eng.abstr-s10-r4-t2.1-t1.2", "type": "surrounds", "arg1_id": "DerNervenarzt.90700119.eng.abstr-s10-t2", "arg2_id": "DerNervenarzt.90700119.eng.abstr-s10-t1", "normalized": [] } ]
DerNervenarzt.90700131.eng.abstr
DerNervenarzt.90700131.eng.abstr
[ { "id": "DerNervenarzt.90700131.eng.abstr-passage-0", "type": "abstract", "text": [ "Myotonic dystrophy is an autosomal dominant multisystem disorder involving muscle , brain , heart , eyes , and endocrine organs . The underlying mutation is an expanding trinucleotide CTG repeat in the 3 ' prime untranslated region of a serine-threonine kinase gene on chromosome 19q . A statistical correlation exists between the CTG copy number and the severity of the disease . Infants with severe congenital myotonic dystrophy have been shown to have on average a greater amplification of the CTG repeat than is seen in the non-congenital myotonic dystrophy population . However , not all patients with many CTG copies develop congenital myotonic dystrophy . We present 13 patients with more than 1500 CTG trinucleotide repeats and show their variable clinical course ." ], "offsets": [ [ 0, 773 ] ] } ]
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"normalized": [ { "db_name": "UMLS", "db_id": "C0040005" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "kinase" ], "offsets": [ [ 254, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031727" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "gene" ], "offsets": [ [ 261, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "chromosome" ], "offsets": [ [ 269, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008633" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "untranslated region" ], "offsets": [ [ 212, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600680" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "serine-threonine kinase" ], "offsets": [ [ 237, 260 ] ], "normalized": [ { "db_name": "UMLS", 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"DerNervenarzt.90700131.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "non-congenital" ], "offsets": [ [ 528, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009678" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "population" ], "offsets": [ [ 562, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "myotonic dystrophy" ], "offsets": [ [ 412, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027126" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "myotonic dystrophy" ], "offsets": [ [ 543, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027126" } ] }, { "id": "DerNervenarzt.90700131.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "congenital myotonic dystrophy" ], "offsets": [ [ 401, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0410226" } ] }, { "id": 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[]
[]
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DerNervenarzt.90700149.eng.abstr
DerNervenarzt.90700149.eng.abstr
[ { "id": "DerNervenarzt.90700149.eng.abstr-passage-0", "type": "abstract", "text": [ "This is a report of an interdisciplinary approach to diagnosis and treatment of stroke , combining a stroke unit and rehabilitation in one clinic . This series contains unselected patients from a narrow surrounding . Mean age of 559 patients was 68.7 years ( median 70 years ) . 25% of patients had an initial Barthel index of 30 , 20% presented with TIA's and PRIND's . 9% suffered from cerebral hemorrhage . The unbroken chain of care allowed a relative short length of stay in the acute care ( 9.4 days ) without prolonging the rehabilitation phase . The one month mortality was 6.7% , one year mortality 18.3% . Discharge to a nursing home was necessary in 5.4% . Overall more than 90% of our patients have been treated continuously in our clinic . Combining modern diagnostics with early onset rehabilitation seem advantageous ." ], "offsets": [ [ 0, 833 ] ] } ]
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[]
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DerNervenarzt.90700155.eng.abstr
DerNervenarzt.90700155.eng.abstr
[ { "id": "DerNervenarzt.90700155.eng.abstr-passage-0", "type": "abstract", "text": [ "Cardiopulmonary exercise testing ( CPX ) is a non-invasive method of recording quantitative data from gas exchange and ventilation for the evaluation of oxidative metabolism at rest and during exercise . Determination of oxygen uptake ( VO2) and carbon dioxide output ( VCO2) describes the activity of anaerobic vs aerobic metabolism . An incremental exercise test measuring gas exchange , ventilation and lactate release was performed in healthy volunteers and in patients suffering from mitochondrial disorders . At rest as well as during exercise patients with mitochondrial disorders differ from healthy subjects with regard to gas exchange and ventilation parameters . During exercise , the decreased oxygen utilization of skeletal muscle and early activation of anaerobic metabolism in these patients are mirrored by a reduced anaerobic threshold , reduced maximal oxygen uptake and reduced oxygen pulse . Our study shows that CPX is a sensitive and practical clinical screening method of investigating mitochondrial disorders ." ], "offsets": [ [ 0, 1034 ] ] } ]
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DerNervenarzt.90700162.eng.abstr
DerNervenarzt.90700162.eng.abstr
[ { "id": "DerNervenarzt.90700162.eng.abstr-passage-0", "type": "abstract", "text": [ "Tay-Sachs disease is caused by Hexosaminidase A deficiency . Symptoms of the enzyme deficiency rarely become clinically manifest in adult age ; then the course of the disease differs in a wide range . We report on a patient with cerebellar ataxia and lower motor neuron disease . Neurophysiological investigations , neuro-imaging ( CT , MRI ) , and muscle biopsy reveal pathological but nonspecific findings . Determination of hexosaminidase A and B activities leads to the diagnosis . In patients with spinocerebellar ataxia hexosaminidase deficiency has to be considered as a differential diagnosis ." ], "offsets": [ [ 0, 602 ] ] } ]
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"id": "DerNervenarzt.90700162.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Hexosaminidase A deficiency" ], "offsets": [ [ 31, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039373" } ] }, { "id": "DerNervenarzt.90700162.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Symptoms" ], "offsets": [ [ 61, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700162.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "enzyme" ], "offsets": [ [ 77, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" }, { "db_name": "UMLS", "db_id": "C0014445" } ] }, { "id": "DerNervenarzt.90700162.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "deficiency" ], "offsets": [ [ 84, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] }, { "id": "DerNervenarzt.90700162.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "adult" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001675" } ] }, { "id": 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[]
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DerNervenarzt.90700167.eng.abstr
DerNervenarzt.90700167.eng.abstr
[ { "id": "DerNervenarzt.90700167.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a patient who suffered from borreliosis-induced severe cerebral vasculitis accompanied by multiple cerebral infarctions leading to hemiparesis , hemianopsia and reduced consciousness . Despite antibiotic and immunosuppressive therapy with ceftriaxon and prednisolone the patients condition deteriorated . Cerebral angiography showed multiple stenoses of large arteries of the posterior circulation and ubiquitous irregularities of small vessel walls . General reduced perfusion reflected an increased peripheral resistance . After 4 weeks of additional immunosuppressive treatment with cyclophosphamide the neurological status and angiographic findings improved dramatically ." ], "offsets": [ [ 0, 689 ] ] } ]
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angiography" ], "offsets": [ [ 318, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007767" } ] }, { "id": "DerNervenarzt.90700167.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 481, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031001" } ] }, { "id": "DerNervenarzt.90700167.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "peripheral resistance" ], "offsets": [ [ 514, 535 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042380" } ] }, { "id": "DerNervenarzt.90700167.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "immunosuppressive" ], "offsets": [ [ 566, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerNervenarzt.90700167.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 584, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700167.eng.abstr-s5-t3", "type": "umlsterm", 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[]
[]
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DerNervenarzt.90700172.eng.abstr
DerNervenarzt.90700172.eng.abstr
[ { "id": "DerNervenarzt.90700172.eng.abstr-passage-0", "type": "abstract", "text": [ "The clinical relevance of being informed on the serum concentration of antiepileptic drugs has been judged very differently during the last decades . Therefore the Commission on the treatment of epilepsy ( German section of the International League against Epilepsy ) had the task to outline the importance of therapeutic monitoring of anticonvulsant serum concentrations ." ], "offsets": [ [ 0, 373 ] ] } ]
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DerNervenarzt.90700195.eng.abstr
DerNervenarzt.90700195.eng.abstr
[ { "id": "DerNervenarzt.90700195.eng.abstr-passage-0", "type": "abstract", "text": [ "A multifactorial etiology underlies the majority of cases of Alzheimer's disease ( AD ) . Both ill-defined environmental and genetic factors contribute to the development of the disease . Allele 4 of ApoE is a genetic risk factor . Its presence increases the risk of developing AD . However , presence of e4 is neither necessary nor sufficient for the disease to arise . Apart from the common multifactorial forms of the disease , there are rare variants which are inherited as Mendelian traits . To date three genes are known that can be mutated in these rare forms of AD . Of these , mutations in the gene presenilin 1 on chromosome 14 are most frequent . In addition , mutations in the gene presenilin 2 on chromosome 1 and in the amyloid precursor protein gene ( APP on chromosome 21 ) occur in autosomal dominant AD . This article reviews our present knowledge of the genetics of AD and discusses its relevance for patients with AD and their relatives ." ], "offsets": [ [ 0, 958 ] ] } ]
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DerNervenarzt.90700206.eng.abstr
DerNervenarzt.90700206.eng.abstr
[ { "id": "DerNervenarzt.90700206.eng.abstr-passage-0", "type": "abstract", "text": [ "Episodes of anxiety have been reported to be the most common psychological symptoms in patients with partial seizures . They may occur before , during and after seizures and can also appear in isolation without any convulsive symptoms . The epileptic anxietysyndrome is strikingly similar to panic attacks , and panic disorder is an important differential diagnosis . The close relationship between epileptic seizures and panic attacks is of special interest for a better pathophysiological understanding of panic attacks . In the literature an epileptiform neuronal activity is discussed as a possible underlying mechanism for panic disorder . The finding that anxiety was the most common experiential phenomenon produced by electrical stimulation of amygdala and hippocampus with depth electrodes points in this direction . PET has demonstrated abnormalities of hippocampal structures during the nonpanic state of patients with panic disorder . In addition , some EEG studies have demonstrated a high incidence of epileptiform EEG patterns in patients with panic disorder with or without agoraphobia . This was the reason why several investigators proposed that a subset of panic attacks may be ralated to abnormal epileptiform neuronal activity in the limbic system . The size of this subset is difficult to determine because discharges in the depth of the limbic system often cannot be seen in the scalp EEG . Concerning the hypothetical pathophysiological mechanism of panic disorder therapeutic measures were taken with antiepileptic agents . The best results were obtained for valproic acid . It seems to be resonable to make a therapeutic trial with antiepileptic medication after nonresponse to standard pharmacotherapy ." ], "offsets": [ [ 0, 1730 ] ] } ]
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[ 251, 266 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700206.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "panic" ], "offsets": [ [ 312, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030318" } ] }, { "id": "DerNervenarzt.90700206.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 318, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700206.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 356, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700206.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "panic attacks" ], "offsets": [ [ 292, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086769" } ] }, { "id": "DerNervenarzt.90700206.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "panic disorder" ], "offsets": [ [ 312, 326 ] 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DerNervenarzt.90700225.eng.abstr
DerNervenarzt.90700225.eng.abstr
[ { "id": "DerNervenarzt.90700225.eng.abstr-passage-0", "type": "abstract", "text": [ "Low back pain ( LBP ) is a widespread disorder . The socioeconomic costs caused by LBP have been increasing dramatically over the past years . These high costs are mainly due to the relatively small percentage of chronic cases . Although the multitude of empirical findings available thus far offer an impressive body of knowledge about the mechanisms and factors responsible for chronification , most LBP-patients are still being treated without their psychosocial situation being taken into account . In addition to providing a discussion of the reasons underlying this imbalance along with a review of our present understanding of Failed Back Syndrome , this article also serves as an argument in favor of an interdisciplinary approach to the treatment of pain ." ], "offsets": [ [ 0, 765 ] ] } ]
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[]
[]
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DerNervenarzt.90700233.eng.abstr
DerNervenarzt.90700233.eng.abstr
[ { "id": "DerNervenarzt.90700233.eng.abstr-passage-0", "type": "abstract", "text": [ "Dysmorphophobia as a new psychiatric syndrome was described by the italian psychiatrist Morselli in 1891. Dysmorphophobic symptoms are associated with several other psychiatric disorders . The term of dysmorphophobia will be discussed along a theoretical review . We present the case of a 20-year-old patient with dysmorphophobic symptoms . In the scope of ICD 10 , DSM-III-R/DSM IV diagnostical criteria we outline problems of the diagnostical classification of dysmorphophobic signs ." ], "offsets": [ [ 0, 486 ] ] } ]
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[]
[]
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DerNervenarzt.90700250.eng.abstr
DerNervenarzt.90700250.eng.abstr
[ { "id": "DerNervenarzt.90700250.eng.abstr-passage-0", "type": "abstract", "text": [ "Despite the diagnostic criteria of the ICD-10 and DSM-IV , the term borderline has been used in a non-specific way for a long time . For our investigation we constructed a questionnaire , which contained the ICD-10 diagnostic criteria for the borderline personality disorder ( BPD ) , plus the criteria for the other personality disorders and for the schizotype disorder . The two additional criteria for the BPD used by the DSM-IV were added . 800 psychiatrists and psychologists were asked to mark all criteria , which they thought were typical for the BPD . By using the operational diagnostic approach for ICD-10 and DSM-IV a disorder was diagnosed from each of the 162 received questionnaires based on the marked criteria . 92,0% of the questionnaires contained marked criteria for the diagnosis of the BPD by ICD-10 and 96,3% by DSM-IV . In addition each questionnaire contained up to eight other diagnosis . This is a sign for the difficulty to separate the BPD from other personalitiy disorders or the schizotype disorder by using operationalised criteria . Looking at the lack of specifity of the operational diagnostic systems for personality disorders , e.g. for the BPD which has been discussed by many authors for years , modification of the diagnostic systems should be considered ." ], "offsets": [ [ 0, 1296 ] ] } ]
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"umlsterm", "text": [ "criteria" ], "offsets": [ [ 226, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "personality" ], "offsets": [ [ 254, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 266, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "BPD" ], "offsets": [ [ 277, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 294, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "personality" ], "offsets": [ [ 317, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 329, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 362, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "borderline personality" ], "offsets": [ [ 243, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "personality disorder" ], "offsets": [ [ 254, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031212" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "personality disorders" ], "offsets": [ [ 317, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031212" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s2-t14", "type": "umlsterm", "text": [ "borderline personality disorder" ], "offsets": [ [ 243, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 392, 400 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "BPD" ], "offsets": [ [ 409, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "psychiatrists" ], "offsets": [ [ 449, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033872" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "psychologists" ], "offsets": [ [ 467, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033908" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 504, 512 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "BPD" ], "offsets": [ [ 555, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 586, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 630, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "questionnaires" ], 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811 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "questionnaire" ], "offsets": [ [ 861, 874 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034394" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 903, 912 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "sign" ], "offsets": [ [ 925, 929 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "BPD" ], "offsets": [ [ 965, 968 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 993, 1002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 1021, 1029 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 1055, 1063 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 1118, 1128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "personality" ], "offsets": [ [ 1141, 1152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 1153, 1162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "BPD" ], "offsets": [ [ 1178, 1181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006012" }, { "db_name": "UMLS", "db_id": "C0006287" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 1255, 1265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700250.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "personality disorders" ], "offsets": [ [ 1141, 1162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031212" } ] } ]
[]
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DerNervenarzt.90700256.eng.abstr
DerNervenarzt.90700256.eng.abstr
[ { "id": "DerNervenarzt.90700256.eng.abstr-passage-0", "type": "abstract", "text": [ "In clinical practice and in research projects the presence of an advance directive or an appointment of a health-care proxy may substantially contribute to decisions of diagnostic and therapeutic interventions , if a person has lost his ability to consent . A special questionnaire was given to a non representative sample of 206 elderly inpatients suffering from different psychiatric disorders . The majority of these patients ( 57% ) supported the necessity of such instruments . In a further 5,4% of the interviewees written documents , either advance directive or determination of a health-care proxy , were already present . However , 25% of the interviewed patients did not approve of the usefulness of these instruments and 12,5% answered that they were not able to give any decision . Among the interviewed patients , age , gender and the psychiatric disorder present were not associated with approval or refusal . However , higher education was related to the approval of advance directives ." ], "offsets": [ [ 0, 1002 ] ] } ]
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[]
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DerNervenarzt.90700262.eng.abstr
DerNervenarzt.90700262.eng.abstr
[ { "id": "DerNervenarzt.90700262.eng.abstr-passage-0", "type": "abstract", "text": [ "Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem . There is evidence suggesting changes in endogenous opioids in patients with Borderline Personality Disorder . Naltrexone , an opioid receptor antagonist , was administered to three female patients with Borderline Personality Disorder in a dosage of 50 mg ( q.i.d. , p.o. ) over several weeks . We observed a marked reduction in dissociative symptoms ." ], "offsets": [ [ 0, 556 ] ] } ]
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[]
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DerNervenarzt.90700265.eng.abstr
DerNervenarzt.90700265.eng.abstr
[ { "id": "DerNervenarzt.90700265.eng.abstr-passage-0", "type": "abstract", "text": [ "The coincidence between panic disorder and depression is a well known phenomenon . However , only few studies investigated the coincidence of panic disorder with schizophrenia . This may in part be explained by the fact that both positive and negative symptoms of schizophrenia may mask the clinical symptoms of a panic disorder . We report on a female patient suffering both from agoraphobia with panic disorder and paranoid schizophrenia according to ICD-10. The productive psychotic symptoms responded well to treatment with a low dose of zotepine , whereas the panic disorder was effectively treated with a combined therapy with imipramine and cognitive behavioral therapy . Although it has to be questioned whether the coincidence between panic disorder and schizophrenia reflects two different diagnostic entities , the occurence of symptoms of a panic disorder in schizophrenia deserve further attention because these may be treated efficiently by a specific pharmacotherapy and psychotherapy ." ], "offsets": [ [ 0, 1001 ] ] } ]
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"normalized": [ { "db_name": "UMLS", "db_id": "C0024861" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 300, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "panic" ], "offsets": [ [ 314, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030318" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 320, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "panic disorder" ], "offsets": [ [ 314, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030319" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 346, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 353, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "agoraphobia" ], "offsets": [ [ 381, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001818" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "panic" ], "offsets": [ [ 398, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030318" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 404, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "schizophrenia" ], "offsets": [ [ 426, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036341" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "psychotic" ], "offsets": [ [ 476, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033975" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 486, 494 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 513, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "zotepine" ], "offsets": [ [ 542, 550 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0078849" } ] }, { "id": "DerNervenarzt.90700265.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "panic" ], "offsets": [ [ 565, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030318" } ] }, { "id": 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[]
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DerNervenarzt.90700269.eng.abstr
DerNervenarzt.90700269.eng.abstr
[ { "id": "DerNervenarzt.90700269.eng.abstr-passage-0", "type": "abstract", "text": [ "Absence of the septum pellucidum is a rare developmental disorder of the human brain . Previous reports focused on the association with other cerebral anomalies . We present MRI scans showing an isolated absence of the septum pellucidum . The patient was suffering from a schizophrenic psychosis . Mental retardation or epileptic seizures , which are often found in more complex developmental brain disorders , were not observed . The septal area is part of the limbic system and aplasia of the septum pellucidum could indicate developmental anomalies of the limbic system . The concept of cerebral maldevelopment and the limbic system in schizophrenic psychosis is discussed ." ], "offsets": [ [ 0, 677 ] ] } ]
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"UMLS", "db_id": "C0008073" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 119, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "anomalies" ], "offsets": [ [ 151, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "MRI" ], "offsets": [ [ 174, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "MRI scans" ], "offsets": [ [ 174, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917711" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "septum pellucidum" ], "offsets": [ [ 219, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036700" } ] }, { "id": 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"C0496899" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 399, 408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "Mental retardation" ], "offsets": [ [ 298, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025362" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "epileptic seizures" ], "offsets": [ [ 320, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014544" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "brain disorders" ], "offsets": [ [ 393, 408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006111" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "aplasia" ], "offsets": [ [ 480, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0334079" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "anomalies" ], "offsets": [ [ 542, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "septal area" ], "offsets": [ [ 435, 446 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0752059" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "limbic system" ], "offsets": [ [ 462, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023715" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "septum pellucidum" ], "offsets": [ [ 495, 512 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036700" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "developmental anomalies" ], "offsets": [ [ 528, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "limbic system" ], "offsets": [ [ 559, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023715" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "psychosis" ], "offsets": [ [ 653, 662 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033975" } ] }, { "id": "DerNervenarzt.90700269.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "limbic system" ], "offsets": [ [ 622, 635 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023715" } ] } ]
[]
[]
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DerNervenarzt.90700276.eng.abstr
DerNervenarzt.90700276.eng.abstr
[ { "id": "DerNervenarzt.90700276.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a patient with metachromatic leukodystrophy ( MLD ) with a first manifestation of homicide . On admission the patient showed a hebephrenia-like syndrom with inappropriate affect , thought disorder and behavioral changes . Magnetic resonance tomography ( MRT ) findings suggested a diagnosis of MLD , which was confirmed by a decreased activity of leucocyte arylsulfatase A and an excessive urinary sulfatide excretion ." ], "offsets": [ [ 0, 429 ] ] } ]
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[]
[]
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DerNervenarzt.90700298.eng.abstr
DerNervenarzt.90700298.eng.abstr
[ { "id": "DerNervenarzt.90700298.eng.abstr-passage-0", "type": "abstract", "text": [ "Neurocysticercosis , caused by Taenia solium larvae ( cysticerci ) , is the most common parasitic infection of the human CNS Worldwide . In Germany its appearance is rare . Here we report two cases of neurocysticercosis which we followed over a period of 4-6 years . The first patient acquired neurocysticercosis in Germany . On admission he suffered from papilledema , partial seizures and a mild psychotic disorder . MR-tomography showed an internal hydrocephalus and multiple contrast enhancing parenchymal cysts . In the course of the disease a giant cyst within the left temporal pole developed and was exstirpated neurosurgically . The persistent internal hydrocephalus required ventriculoperitoneal shunting . Therapy with Praziquantel led to a clinical improvement , however , repeated analysis of the cerebrospinal fluid documented peristent inflammation . With the aid of a contrast enhanced three-dimensional ( 3D ) ultrasound imaging technique we demonstrated increased cerebral perfusion surrounding one cyst . This may be interpreted as evidence for persistent disease activity . The second patient presented with repeated episodes of cysticercotic encephalitis , which is rarely described in the literature ( incidence 1% ) . Clinical features , laboratory findings , diagnosis , and therapy of neurocysticercosis will be presented together with the pitfalls of the two described cases . Our cases will be compared to previous reports on clinical findings in neurocysticercosis ." ], "offsets": [ [ 0, 1494 ] ] } ]
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[]
[]
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DerNervenarzt.90700306.eng.abstr
DerNervenarzt.90700306.eng.abstr
[ { "id": "DerNervenarzt.90700306.eng.abstr-passage-0", "type": "abstract", "text": [ "Solvent induced polyneuropathy and encephalopathy have been acknowledged quite recently as occupational diseases in Germany . For compensation first of all the diagnosis has to be proven . For differential diagnosis other known causes as well as non-organic mental diseases must be taken into consideration . The causality between proven exposures and diagnosed disease has at least to be probable . To evaluate causation extensive experience of the experts is needed . In this context scientific criteria regarding neurotoxicity of the solvent , duration of exposure , individual aspects of non-occupational influences , time course of the disease are important within a thorough synoptic evaluation . Possibilities and limitations of sensitive diagnostic measures such as neurographic , neuropsychologic and neuroimaging examinations are discussed . The prognosis of toxic polyneuropathy and encephalopathy is in general favorable if exposure has stopped . Additionally , adequate therapy and rehabilitation measures are supportive for a good prognosis ." ], "offsets": [ [ 0, 1056 ] ] } ]
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[]
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DerNervenarzt.90700315.eng.abstr
DerNervenarzt.90700315.eng.abstr
[ { "id": "DerNervenarzt.90700315.eng.abstr-passage-0", "type": "abstract", "text": [ "Drug-associated/-induced neurological complications are well known in the literature . Cocaine is of major interest due to its widespread use . On the basis of a case report , we discuss the broad spectrum of medical and , in particular , neurological complications . The risk of cerebrovascular damage and epileptic seizures is indicated . The pathophysiological mechanisms of cerebrovascular complications are not well understood ." ], "offsets": [ [ 0, 433 ] ] } ]
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[]
[]
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DerNervenarzt.90700330.eng.abstr
DerNervenarzt.90700330.eng.abstr
[ { "id": "DerNervenarzt.90700330.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and purpose : Only a few clinical reports about the routine use of intravenous rt-PA for the treatment of acute ischemic stroke have been published . Wether the perfusion of the extracranial parts of the internal carotid artery influences the outcome of the patients is still unknown , because the two major studies about systemic thrombolytic therapy with rt-PA in stroke ( ECASS and NINDS ) did not formally assess the status of the extracranial vessels ." ], "offsets": [ [ 0, 468 ] ] } ]
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[]
[]
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DerNervenarzt.90700335.eng.abstr
DerNervenarzt.90700335.eng.abstr
[ { "id": "DerNervenarzt.90700335.eng.abstr-passage-0", "type": "abstract", "text": [ "In order to describe autonomic dysfunction and clinical outcome in complex regional pain syndrome ( CRPS ) 20 patients were followed-up . First investigation was performed in the acute stage of CRPS and the second investigation two years later after therapy ( individual , not standardized ) . Skin temperature and sudomotor function ( thermoregulatory sweating ( TST ) and quantitative sudomotor axon reflex ( QSART ) ) were assessed , and a clinical follow-up was performed carefully . Skin temperature was warmer on the affected side at first investigation ( p 0.001 ) and colder at follow-up ( p 0.02 ) . Sudomotor output was enhanced on the affected side both after TST ( p 0.005 ) and QSART ( p 0.05 ) at first investigation . At follow-up , however , while thermoregulatory sweating was still increased ( p 0.04 ) QSART was not different . While autonomic failure improves as assessed by clinical examination , therapy failed to alleviate pain significantly . But patients ' selfassesment of therapy was mostly positive ( 16 of 20 , p 0.001 ) . The present study has shown that the autonomic failure may be probably the result of central disturbances of thermoregulation , but secondary peripheral mechanisms also contribute to our findings . Individual based therapy seems to be efficacious for long term treatment , but for final judge controlled studies are required ." ], "offsets": [ [ 0, 1378 ] ] } ]
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[]
[]
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DerNervenarzt.90700342.eng.abstr
DerNervenarzt.90700342.eng.abstr
[ { "id": "DerNervenarzt.90700342.eng.abstr-passage-0", "type": "abstract", "text": [ "Thrombembolic events as paraneoplastic complications in malignant disease account for severe morbidity and mortality in these patients . In some cases disturbance in hemostasis is the first manifestation of a neoplastic process . We report the cases of two patients with cerebral and extracerebral vessel occlusions , in whom epithelial tumors of low malignant potential ( borderline-tumors ) of ovar and peritoneum were diagnosed later on . In one case the removal of the tumor stopped the coagulation problems . The second patient died a few days after the first symptoms with devastating multiple vessel occlusion . In stroke of unknown aetiology a paraneoplastic process should be kept in mind . The diagnosis is more probable with recurrent thrombembolism in different body regions and when warfarin therapie was ineffective . Thoughtful coagulation studies and a tumor search program is recommended in these cases ." ], "offsets": [ [ 0, 921 ] ] } ]
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"db_id": "C0026565" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 126, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "hemostasis" ], "offsets": [ [ 166, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019116" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "neoplastic process" ], "offsets": [ [ 209, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027671" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 257, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 298, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 337, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 351, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "peritoneum" ], "offsets": [ [ 405, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031153" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "epithelial tumors" ], "offsets": [ [ 326, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205853" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 473, 478 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "coagulation" ], "offsets": [ [ 491, 502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005790" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 525, 532 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 565, 573 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 600, 606 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "patient died" ], "offsets": [ [ 525, 537 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "stroke" ], "offsets": [ [ 622, 628 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038454" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "aetiology" ], "offsets": [ [ 640, 649 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 704, 713 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "warfarin" ], "offsets": [ [ 796, 804 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "therapie" ], "offsets": [ [ 805, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034068" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "body regions" ], "offsets": [ [ 774, 786 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005898" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "coagulation" ], "offsets": [ [ 843, 854 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005790" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 869, 874 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 882, 889 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerNervenarzt.90700342.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "coagulation studies" ], "offsets": [ [ 843, 862 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005790" } ] } ]
[]
[]
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DerNervenarzt.90700349.eng.abstr
DerNervenarzt.90700349.eng.abstr
[ { "id": "DerNervenarzt.90700349.eng.abstr-passage-0", "type": "abstract", "text": [ "Until now , the pathogenesis of Marchiafava-Bignami disease , an extrapontine myelinolysis , is unknown . Accept an abuse of alcohol for many years additional metabolic and vascular disturbances are supposed . The early performance of magnetic resonance imaging in patients with a sudden encephalopathy and history of alcoholism is essential for an assessment of the diagnosis . The bilateral lack of transcallosal inhibition - a parameter for the integrity of the transcallosal connections between motor cortices - is the consequence of the axonal degeneration of transcallosal fibers . Clinical and neuroradiological features of three patients with extrapontine myelinolysis are reported and possible etiologies of the complex disease are discussed . In two cases a severe alcohol abuse was present with the typical picture of the Marchiafava-Bignami disease . In a third patient an intoxication with methanol was present with a similar clinical picture . Although severe neurological disturbances were initially apparent in the patients , during the follow-up there was a significant amelioration of the clinical course under a high-dose vitamin B supplementation ." ], "offsets": [ [ 0, 1168 ] ] } ]
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[]
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DerNervenarzt.90700357.eng.abstr
DerNervenarzt.90700357.eng.abstr
[ { "id": "DerNervenarzt.90700357.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a 72-year-old patient who developed an isolated bilateral hypoglossal nerve paralysis following head trauma with complete recovery after three months . Since the CT scan did not show any fractures of the posterior skull base , we discuss a traction nerve injury as a possible mechanism ." ], "offsets": [ [ 0, 297 ] ] } ]
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[]
[]
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DerNervenarzt.90700363.eng.abstr
DerNervenarzt.90700363.eng.abstr
[ { "id": "DerNervenarzt.90700363.eng.abstr-passage-0", "type": "abstract", "text": [ "The diagnosis of leptomeningeal dissemination of chronic lymphatic leukemia ( CLL ) by conventional cytology is unreliable because cytomorphologic criteria of malignancy are often lacking . Immunophenotyping of leukocyte differentiation antigens may also be of limited diagnostic value due to the small number of cells in cerebrospinal fluid ( CSF ) samples . Molecular methods may support the specific diagnosis of leptomeningeal infiltration of CLL . We present an 54 old patient who was diagnosed with CLL five years ago . Despite clinical signs of leptomeningeal involvement neither magnetic resonance imaging ( MRI ) nor conventional CSF analysis were suggestive of lymphomatous meningitis . Using PCR we selectively amplified the highly variable and clone-specific CDR3 region of the locus encoding the immunoglobulin heavy chain ( IgH ) in DNA obtained from both CSF and peripheral blood cells . Analysis of PCR products by high resolution gel electrophoresis revealed a single DNA fragment respectively indicating the presence of a monoclonal cell population in both compartments . DNA sequence analysis of the amplified CDR3 segments confirmed the clonal identity of cells and the leptomeningeal dissemination of CLL ." ], "offsets": [ [ 0, 1227 ] ] } ]
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DerNervenarzt.90700368.eng.abstr
DerNervenarzt.90700368.eng.abstr
[ { "id": "DerNervenarzt.90700368.eng.abstr-passage-0", "type": "abstract", "text": [ "The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate ." ], "offsets": [ [ 0, 871 ] ] } ]
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[]
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DerNervenarzt.90700371.eng.abstr
DerNervenarzt.90700371.eng.abstr
[ { "id": "DerNervenarzt.90700371.eng.abstr-passage-0", "type": "abstract", "text": [ "The positive results of several multi-center studies significantly improved the immunomodulatory treatment of multiple sclerosis over the last few years . It was demonstrated that different compounds are capable to reduce the number of relapses and to modulate the progression of disease . To improve the transition of results obtained in these studies into daily clinical practice , a consensus group started to prepare a report on the current treatment options for the German-speaking European countries . The aim of this paper is to summarize the current knowledge , compare the results of recent clinical trials with the experience from other therapeutic options and assess their clinical evidence ." ], "offsets": [ [ 0, 703 ] ] } ]
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[]
[]
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DerNervenarzt.90700387.eng.abstr
DerNervenarzt.90700387.eng.abstr
[ { "id": "DerNervenarzt.90700387.eng.abstr-passage-0", "type": "abstract", "text": [ "Economic evaluations have become more and more important in the somatotherapeutic field . This survey's objective was to examine if the current economic evaluation techniques can be applied to psychotherapy . 8 data banks , 17 key words from the psychotherapeutic field and 14 economic key words were used , the identified original studies were classified in accordance with Drummond , the methodical quality of each study was assessed at a score between 0 and 10 points . 21 studies were found : 16 cost- benefit analyses , 4 cost-effectiveness analyses and one cost-utility analysis . The quality of the representation of the clinical results ( mean value 8.6 ) was better than that of the economic results ( mean value 6.1 ) . It was perfectly possible to evaluate psychotherapeutic interventions with regard to economic aspects by means of the current techniques but in most cases there was a considerable lack of quality in both representation and calculation . Furthermore the evaluation type of cost-utility analysis , which is the only one that takes quality of life aspects into consideration and therewith seems to be the most appropriate approach regarding the psychotherapeutic field , has been greatly ignored ." ], "offsets": [ [ 0, 1224 ] ] } ]
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DerNervenarzt.90700399.eng.abstr
DerNervenarzt.90700399.eng.abstr
[ { "id": "DerNervenarzt.90700399.eng.abstr-passage-0", "type": "abstract", "text": [ "It has been suggested that anhedonia , the loss of pleasure , is associated with a dysfunction of the dopaminergic reward system in schizophrenic and alcohol-dependent patients . In a series of neuroendocrinological and brain imaging studies , we examined pre- and postsynaptic mechanisms of dopaminergic neurotransmission in non-human primates and in schizophrenic and alcohol-dependent patients . Among alcoholics , we found indicators of a sensitization of dopaminergic neurotransmission , which was associated with the relapse risk , but not with anhedonia or depression . Schizophrenics with neuroleptic blockade of striatal dopamine D2 receptors displayed psychomotor slowing and reduced motivation , but not anhedonia . Primate studies pointed to the importance of a temporo-cortical dysfunction in the pathogenesis of phasic dopaminergic dysregulation in the striatum . These observations indicate that a dysfunction of stimulus-dependent dopamine release may be associated with motivational deficits caused by a reduction in incentive salience , but not with anhedonia ." ], "offsets": [ [ 0, 1079 ] ] } ]
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DerNervenarzt.90700408.eng.abstr
DerNervenarzt.90700408.eng.abstr
[ { "id": "DerNervenarzt.90700408.eng.abstr-passage-0", "type": "abstract", "text": [ "By administering an extensive battery of neuropsychological tests , cognitive performance of 66 patients with first episode schizophrenia , 49 patients with chronic schizophrenia and 40 healthy controls has been assessed in the areas of memory functions , speech and cognitive flexibility/ abstraction . The three groups were comparable with regard to age , gender and education . Both patient groups showed a significant generalized neuropsychological impairment relative to controls . Patients with first episode were most impaired in visual motor processing and attention ( VSM ) . Besides impairment in VSM , performance in abstraction/flexibility was significantly worse in chronic schizophrenics compared to first episode schizophrenics . Our findings suggest that neuropsychological functions are already impaired at the onset of the illness . Whether cognitive impairment in performance that is attributed to frontal dysfunctions is deteriorating during the course of the illness or is predicting an unfavourable course can only be answered by prospective follow-up studies ." ], "offsets": [ [ 0, 1083 ] ] } ]
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DerNervenarzt.90700416.eng.abstr
[ { "id": "DerNervenarzt.90700416.eng.abstr-passage-0", "type": "abstract", "text": [ "The issue of this study was the investigation of the dimensional structure of non-psychotic and psychotic symptoms in 232 first-episode schizophrenic patients ( ICD-9 295. , 297. , 298.3 , 298.4 ) . The study was conducted within the ABC-Schizophrenia-Study . The three-factor-model of Liddle with three factors ( psychomotor poverty , disorganisation , reality distortion ) was replicated for the time at first admission . The model is also valid for first-episode-patients as well as to chronic patients . The comparison of the three-factor-model of Liddle with Crow's dual process model , Andreasen's bipolar model and the \" severity-liability \" model was done by means of confirmatory factor analysis . The comparison shows that at first admission , the three-factor-model fitted in best with the data . In contrast to previous analyses within the ABC-Study , in which positive correlations have been found between positive and negative symptoms , no positive correlation exists between Liddle's negative and positive dimensions . This may be the consequence of the subdivision of the positive dimension into the two dimensions disorganisation and psychotic symptoms . As within the three-factor-model only the negative dimension and disorganisation correlated weekly , the three dimensions are best viewed as relatively independent for the time at first admission . There are no associations between sex , type of onset , age at onset and the three dimensions of Liddle's model . Patients with the familial load are more disorganized and patients with obstetric complications show more negative symptoms . While the negative dimension shows a high stability over five years , the dimensions \" disorganisation \" and \" positive symptoms \" are not stable over time . However , there is a high degree of correlation for the dimensions \" disorganization \" and \" positive symptoms \" among cross-sections while the negative dimension was independent of the other two dimensions . The negative dimension is a highly significant predictor for social disability and social development over five years , whereas the dimensions \" disorganization \" and \" positive symptoms \" have no prognostic importance for the outcome in the long term ." ], "offsets": [ [ 0, 2231 ] ] } ]
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[]
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DerNervenarzt.90700430.eng.abstr
DerNervenarzt.90700430.eng.abstr
[ { "id": "DerNervenarzt.90700430.eng.abstr-passage-0", "type": "abstract", "text": [ "In the present study disorders of thinking were studied in normals , patients with neurotic disorders , borderline patients and both acute and chronic schizophrenics . Disorders of thinking were assessed by the Holtzman Inkblot Technique . By a factor analysis , different dimensions of disordered thinking characteristic of the different diagnostic groups could be identified . Among others two dimensions of schizophrenic thought disorder and one of borderline thought disorder could be identified . This latter dimension showed high correlations with anxiety and hostility . This was true for a dimension of productive schizophrenics thought disorders , but not for a dimension of negative schizophrenics thought disorders ." ], "offsets": [ [ 0, 727 ] ] } ]
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[]
[]
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DerNervenarzt.90700444.eng.abstr
DerNervenarzt.90700444.eng.abstr
[ { "id": "DerNervenarzt.90700444.eng.abstr-passage-0", "type": "abstract", "text": [ "In this study we investigated whether , in conjunction with neuroleptics , a psychoeducational and cognitively oriented treatment for schizophrenic outpatients and their key-persons can improve the course of schizophrenic illness within a 2-year follow-up . This prospective randomized study covered a total of 191 schizophrenic patients ( according to DSM-III-R ) and comprised a psychoeducational training and cognitive psychotherapy for patients and counseling for their key persons in various combinations . Patients were examined before , immediately after and 2 years after the end of the intervention . Patients in the treatment groups reduced their overall psychopathology and their attention deficit . For patients receiving all three treatment conditions , there was a relevant preventive effect with regard to the rehospitalization rate appearing during the second year of the follow-up . We conclude that in the mid-term , a combination of psychoeducational and cognitively oriented therapy for patients and their keypersons can improve the course of schizophrenic illness ." ], "offsets": [ [ 0, 1086 ] ] } ]
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[]
[]
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DerNervenarzt.90700450.eng.abstr
DerNervenarzt.90700450.eng.abstr
[ { "id": "DerNervenarzt.90700450.eng.abstr-passage-0", "type": "abstract", "text": [ "In comparison to the middle of the 80th , the group of patients who are addicted to legal and illegal drugs and are treated in special forensic hospitals , has significantly changed . Polyvalent dependence is the predominant diagnosis . There has been an increase in violence of index delinquency . In the middle of the 80th , most of the patients were committed because of criminal offences against the BtMG ( German law to sentence drug abusers ) . Today , robbery turns out to be the \" classical \" index delinquency . The problem of defining \" false admission \" to a forensic hospital has to be considered in a multidimensional way ." ], "offsets": [ [ 0, 636 ] ] } ]
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[]
[]
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DerNervenarzt.90700457.eng.abstr
DerNervenarzt.90700457.eng.abstr
[ { "id": "DerNervenarzt.90700457.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of our experimental study was to gain informations and data on the driving ability of patients undergoing a methadone substitution programme as well as to explore the influence of an HIV infection . 28 patients , five of them HIV-positive , were compared to a control group equal in age , sex and education . For the traffic relevant tests the methadone patients showed significantly reduced performance . Six of the methadone patients passed the tests in a way regarded to have sufficient driving skills . We were unable to prove an influence of HIV infection on driving skills when lacking relevant somatic and neuropsychiatric symptoms . There was no significant correlation between the test results and patients age or dose of medication . We conclude that in general methadone substitution does not implicate driving inability although the majority of our patients showed some reduction of their psychomotoric skills ." ], "offsets": [ [ 0, 931 ] ] } ]
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"infection" ], "offsets": [ [ 195, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "HIV infection" ], "offsets": [ [ 191, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019693" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 210, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 268, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 291, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "sex" ], "offsets": [ [ 297, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079399" }, { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "education" ], "offsets": [ [ 305, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013621" }, { "db_name": "UMLS", "db_id": "C0013622" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "control group" ], "offsets": [ [ 268, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009932" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "tests" ], "offsets": [ [ 342, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "methadone" ], "offsets": [ [ 352, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025605" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 362, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "methadone" ], "offsets": [ [ 425, 434 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025605" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 435, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "tests" ], "offsets": [ [ 455, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "HIV" ], "offsets": [ [ 555, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019682" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 559, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 638, 646 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "HIV infection" ], "offsets": [ [ 555, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019693" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 698, 702 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 715, 723 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 724, 727 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "medication" ], "offsets": [ [ 739, 749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "methadone" ], "offsets": [ [ 780, 789 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025605" } ] }, { "id": "DerNervenarzt.90700457.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 869, 877 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]
[]
[]
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DerNervenarzt.90700463.eng.abstr
DerNervenarzt.90700463.eng.abstr
[ { "id": "DerNervenarzt.90700463.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Cost-effectiveness analyses complete clinical evaluation studies and thereby support the a well based estimation of therapy efficiency . Aim : A qualified ( extended ) alcohol withdrawal treatment programme ( II ) , which was previously described and evaluated by face-to-face follow-up studies , was analyzed with regard to cost-effectiveness . Sample : 57 alcohol-dependent patients , which had undergone programme II , were compared with 37 patients after a medical detoxification programme ( I ) . Methods : Health insurance data ( number and length of all hospitalisations , days of incapacity to work , days of financial substitution for incapacity to work ) were assessed for the five years before and after index therapy and for each year , separateley . Results : While there were no substantial differences for the time before index therapy , programme II patients were hospitalized after index therapy ( i ) less frequently ( 3.5+4.4 vs. 7.3+11.3 times ) , ( ii ) for fewer days ( 66+75 vs. 136+167 ) than programme I patients , and they received financial support for fewer days ( 67 +/- 73 vs 220 +/- 187 days ) . Conclusion : Considering a somewhat better clinical outcome of programme II vs. programme I patients ( 14% greater abstinence rate within one year ) the significantly lower rates and fewer days of follow-up hospitalisations support a sufficient efficiency of the extended alcohol withdrawal treatment programme ." ], "offsets": [ [ 0, 1452 ] ] } ]
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DerNervenarzt.90700471.eng.abstr
DerNervenarzt.90700471.eng.abstr
[ { "id": "DerNervenarzt.90700471.eng.abstr-passage-0", "type": "abstract", "text": [ "We report the history of a 38 year old patient who began to develop mental deterioration at the age of 26. After a time of 7 years neurological signs like writing dystonia occured . Hallervorden-Spatz-Desease ( HSD ) was diagnosed at the age of 36 in vivo with the clinical presentation of severe dystonia , rigidity , dementia , and typical signal loss in the globus-pallidus the reticular part of the substantia nigra , and the nucleus ruber in the T-2 weighted MRI . The \" eye-of-the-tiger \" -sign , a bilateral hyperintensity in the rostral globus pallidus , was not observed in follow-up examinations . HSD is a rare autosomal-recessive or sporadic disease of unknown etiology . In one third of the patients a dementing process is the first clinical sign of the disorder , and is a rare differential diagnosis of early onset dementia ." ], "offsets": [ [ 0, 840 ] ] } ]
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[]
[]
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DerNervenarzt.90700491.eng.abstr
DerNervenarzt.90700491.eng.abstr
[ { "id": "DerNervenarzt.90700491.eng.abstr-passage-0", "type": "abstract", "text": [ "The hereditary ataxias are a heterogeneous group of inherited neurodegenerative disorders characterised by progressive ataxia that results from degeneration of the cerebellum and its afferent and efferent connections . With respect to the pathogenic mechanisms , the hereditary ataxias may be tentatively divided into three groups : ( 1 ) The recessive ataxias are induced by the functional impairment of a protein that is essential for the survival of specific neurons while the autosomal dominant ataxias are either caused by ( 2 ) mutations of genes coding for ion channels thus resulting in a channelopathy or by ( 3 ) a novel deleterious function of a extended polyglutamine sequence within the proteins encoded by the respective genes ." ], "offsets": [ [ 0, 742 ] ] } ]
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DerNervenarzt.90700496.eng.abstr
DerNervenarzt.90700496.eng.abstr
[ { "id": "DerNervenarzt.90700496.eng.abstr-passage-0", "type": "abstract", "text": [ "Although dementia is described as one of the constituent characteristics of normal pressure hydrocephalus ( NPH ) , alongside gait disturbances and urinary incontinence , there is a rather limited number of controlled studies concerning neuropsychological deficits in the disease . A wide range of psychopathologically relevant symptoms have been described , but the common features of most cases include mental and motor slowing , apathy , emotional indifference , anosognosia , memory and attentional impairment . A number of other functional deficits such as dyslexia , dysgraphia , acalculia , apraxia can also frequently be found . Some emphasis is put on the work of J. de Mol ( Brussels ) which appears to be most important for the study of neuropsychological symptoms in NPH patients . The methodological standard of a number of studies has been found to be rather low , and yet a sound neuropsychological investigation may be of utmost importance for the diagnosis and neurosurgical outcome assessment . Concerning morphological correlates of the functional deficits in NPH , various hypotheses have been formulated , but it is argued that symptoms can neither be described as predominantly \" diffuse \" in nature , nor can they be reduced to unilocular dysfunctions . Recommendations for future research strategies are formulated ." ], "offsets": [ [ 0, 1340 ] ] } ]
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[]
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DerNervenarzt.90700504.eng.abstr
DerNervenarzt.90700504.eng.abstr
[ { "id": "DerNervenarzt.90700504.eng.abstr-passage-0", "type": "abstract", "text": [ "Since mitochondrial diseases lead frequently to severe phenotypes and are often hereditary , there is a need for genetic counselling of the affected families . The specific features of mitochondrial genetics , however , hamper straightforward definition of recurrence risks as in Mendelian diseases . Empirical risks were recently provided for MELAS and MERRF syndromes and for Leber hereditary optic neuropathy . In MELAS and MERFF , higher levels of mutant mtDNA in the mothers ' blood were associated with an increased frequency of affected offspring . Chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome are in general sporadic disorders without increased recurrence risks in the offspring . As Leigh syndrome is found with maternal , autosomal recessive or X chromosomal transmission , the definition of the molecular defect is crucial for genetic counselling . Prenatal diagnosis was reported only in one case of mitochondrial disease so far , and in our opinion it remains questionable because of the uncertain correlation of the proportion of mutant DNA in chorionic villi and in clinically relevant tissues such as brain ." ], "offsets": [ [ 0, 1150 ] ] } ]
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[]
[]
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DerNervenarzt.90700517.eng.abstr
DerNervenarzt.90700517.eng.abstr
[ { "id": "DerNervenarzt.90700517.eng.abstr-passage-0", "type": "abstract", "text": [ "The use of stereotactic methods for the resection of subcortical lesions is heavily advoacted in clinical neurosurgery introducing the term \" neuronavigation \" . Though being an unequivacally elegant technique for the localisation and delineation of pathological lesions in the central nervous system neuronavigation has not been validated by any prospective randomized controlled trial . The method is prone to significant errors as to the intraoperative localisation based upon preoperative threedimensional images . The maximum error can be up to 2.6 cm depending on the extent of the so-called brain shift . In comparison classical frame based stereotaxy has a mean error of +/- 1 mm and remains the gold standard for the exact threedimensional localisation of a given lesion . The value of neuronavigation is evident for small deep seated vascular lesions . For metastatic tumors or skull base tumors the usefullness is rather marginal because alternative therapies are available with proven and equivalent efficacy and reduced morbidity on one hand , and because of the anatomy of the tumor which makes neuronavigation unnecessary . For the currently most common application of neuronavigation , i.e. surgery of gliomas , no significant improvements of therapeutic results can be expected from neuronavigation . The biology of gliomas limits any mechanical approaches ." ], "offsets": [ [ 0, 1375 ] ] } ]
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DerNervenarzt.90700522.eng.abstr
DerNervenarzt.90700522.eng.abstr
[ { "id": "DerNervenarzt.90700522.eng.abstr-passage-0", "type": "abstract", "text": [ "Chronic primary headache has a considerable impact on the quality of life . To date , this impact has been evaluated by measurements of the general pain specific impairment of the quality of life . Headache specific measurements of quality of life or of disability caused by the headache are still missing for the German language . In America , a headache specific questionnaire , the \" Headache Disability Inventory \" ( HDI ) , has been evaluated which is used in the presented study to create a German version , the \" Inventar zur Beeintraechtigung durch Kopfschmerzen \" ( IBK ) . 94 consecutive patients with a primary headache disorder ( 59 female , 35 male ; mean age 40 +/- 12 years ) were examined . Cronbach's alpha was a=0.90, the test-retest-reliability after three months was r=0.87. An analysis of subscales for emotional and functional disability showed similar values for the internal consistency and the test-retest-reliability of these subscales . The scores of the different headache types did not differ significantly . In post-hoc-analyses , however , cluster headache showed higher disability scores than migraine both in the total scale and in the subscales . The total score of the IBK was significantly correlated with the number of headache days per month ( r=0.41; p 0.0003 ) but not with the duration of disease or other demographic parameters . The IBK is the first German headache specific measurement of certain aspects of the quality of life in chronic headache patients . It can be used in clinical settings to evaluate the current state of the patient or to monitor treatment and it can be used for scientific studies ." ], "offsets": [ [ 0, 1651 ] ] } ]
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[]
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DerNervenarzt.90700530.eng.abstr
DerNervenarzt.90700530.eng.abstr
[ { "id": "DerNervenarzt.90700530.eng.abstr-passage-0", "type": "abstract", "text": [ "The term \" frontal lobe syndrome \" comprises a variety of different clinical syndromes produced by focal lesions involving the prefrontal cortex . However , similar syndromes can be observed after lesions involving subcortical structures connected with the prefrontal cortex in neuronal networks . With respect to the different clinical pictures and underlying brain lesions , prefrontal lobe dysfunction may be divided into a disorganized type , caused by lesion of the dorsolateral prefrontal lobe and its connections , a disinhibited type that can be observed following lesions of the orbitofrontal cortex , and an apathetic type following lesions affecting the functional balance between the cingulum and the supplementary motor area . As intracerebral lesions are rarely limited to the brain regions described , in the majority of patients various degrees of behavioural dysfunction can be observed . The case reports of four patients illustrating the three major prefrontal syndroms following severe head injury ( n=2) or cerebrovascular disease ( n=2) are presented and diagnostic implications as well as possible treatment strategies are discussed ." ], "offsets": [ [ 0, 1157 ] ] } ]
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[]
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DerNervenarzt.90700539.eng.abstr
DerNervenarzt.90700539.eng.abstr
[ { "id": "DerNervenarzt.90700539.eng.abstr-passage-0", "type": "abstract", "text": [ "Moderate hypothermia was induced in 30 patients with malignant middle cerebral artery ( MCA ) territory infarction . Patients were kept at 33 °C body-core temperature for 48 to 72 h , and ICP , CPP , and brain temperature were monitored . Outcome at 4 weeks and at 3 months after the stroke as well as side effects of moderate hypothermia were analysed . Mortality of malignant MCA infarction could be reduced from 80% in historical controls , to 43% ( 13/30 ) under hypothermia . During hypothermia elevated ICP values could be significantly reduced . Herniation due to a secondary rise of ICP after rewarming was the cause of death in all 13 patients . The most frequent complication of moderate hypothermia was pneumonia in 12 of the 30 patients ( 40% ) . Other severe side effects of hypothermia could not be detected . Moderate hypothermia may improve clinical outcome in patients with malignant MCA infarction ." ], "offsets": [ [ 0, 917 ] ] } ]
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[]
[]
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DerNervenarzt.90700547.eng.abstr
DerNervenarzt.90700547.eng.abstr
[ { "id": "DerNervenarzt.90700547.eng.abstr-passage-0", "type": "abstract", "text": [ "A 22-year-old male with juvenile dermatomyositis presented with fever up to 40 °C and acute pain in his right thigh accompanied by muscle weakness , a skin rash and a tender swelling . Serum aspartate aminotransferase ( AST ) and aldolase were mildly elevated . C-reactive protein ( CRP ) and fibrinogen were markedly increased . The differential white blood cell count revealed relative lymphopenia . Radiography showed diffuse calcifications particularly around the thighs and knees of both legs . Magnetic resonance imaging ( MRI ) demonstrated inflammatory infiltrates in the right thigh . The lesions were identified as phlegmone by immunoszintigraphy with 99mTc-labelled antigranulocyte antibodies . On the 10th day of treatment Staphylococcus aureus was cultured from blood . Patients with juvenile dermatomyositis and calcinosis may develop bacterial infections of soft tissue which sometimes mimic a disease flare . For differential diagnosis plain radiographs , CT scans and MRI are of limited value . Immunoszintigraphy is able to differentiate between infiltrates caused by granulocytes and lymphocytes ." ], "offsets": [ [ 0, 1116 ] ] } ]
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[]
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DerNervenarzt.90700552.eng.abstr
DerNervenarzt.90700552.eng.abstr
[ { "id": "DerNervenarzt.90700552.eng.abstr-passage-0", "type": "abstract", "text": [ "Within the last years several reports concerning visual field defects , associated with antiepileptic drugs , have been published . In addition to antiepileptic drugs several other causes ( e.g. retinopathy or chloroquine , phenothiazine etc. ) may induce visual field disturbances . Visual field defects have been observed during vigabatrine , tiagabine , gabapentine , diazepam , phenytoine , and carbamazepine treatment . In 13 to 46% visual field defects are reported to be linked with epilepsies . In addition to general population based studies concerning visual field defects and prospective etiological studies in epilepsies , preclinical studies for the examination of the pathomechanism of visual field defects are necessary ." ], "offsets": [ [ 0, 736 ] ] } ]
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"DerNervenarzt.90700552.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "visual field defects" ], "offsets": [ [ 49, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036454" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "antiepileptic" ], "offsets": [ [ 147, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003299" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 161, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 181, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "retinopathy" ], "offsets": [ [ 195, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035309" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "chloroquine" ], "offsets": [ [ 210, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008269" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "phenothiazine" ], "offsets": [ [ 224, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031436" }, { "db_name": "UMLS", "db_id": "C0031434" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "antiepileptic drugs" ], "offsets": [ [ 147, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003299" }, { "db_name": "UMLS", "db_id": "C0003286" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "visual field" ], "offsets": [ [ 256, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042826" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 297, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tiagabine" ], "offsets": [ [ 345, 354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0068897" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "diazepam" ], "offsets": [ [ 371, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012010" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "carbamazepine" ], "offsets": [ [ 399, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006949" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 413, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "Visual field" ], "offsets": [ [ 284, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042826" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "Visual field defects" ], "offsets": [ [ 284, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036454" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 451, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "epilepsies" ], "offsets": [ [ 490, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014544" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "visual field" ], "offsets": [ [ 438, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042826" } ] }, { "id": "DerNervenarzt.90700552.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "visual field defects" ], "offsets": [ [ 438, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036454" } ] }, { "id": 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[]
[]
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DerNervenarzt.90700560.eng.abstr
DerNervenarzt.90700560.eng.abstr
[ { "id": "DerNervenarzt.90700560.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a case of visual loss and bilateral papilloedema under therapy with the antiarrhythmic substance amiodarone , which is used in treatment of refractory and life-threatening supraventricular and ventricular cardial tachyarrhythmias . After excluding intracranial hypertension , local tumors and an inflammatory genesis we consider this case to be an amiodarone-induced toxic opticusneuropathy . Amiodarone , a diiodated benzofuran derivative , is a cationic amphiphilic drug , which is able to cause ceratopathy and neuropathy . The rarely described and less known opticusneuropathy caused problems in differential diagnosis . A brief review about current knowledge of pathophysiology , differential diagnosis and course of illness is presented ." ], "offsets": [ [ 0, 754 ] ] } ]
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[]
[]
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DerNervenarzt.90700566.eng.abstr
DerNervenarzt.90700566.eng.abstr
[ { "id": "DerNervenarzt.90700566.eng.abstr-passage-0", "type": "abstract", "text": [ "Fatigue is a common symptom in patients with multiple sclerosis . Rapid exhaustion and reduced exercise tolerance leads to difficulties in maintaining a normal daily life for many patients . Regular resting and short breaks can help to compensate this to a certain degree ." ], "offsets": [ [ 0, 273 ] ] } ]
[ { "id": "DerNervenarzt.90700566.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Fatigue" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015672" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "symptom" ], "offsets": [ [ 20, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 31, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "sclerosis" ], "offsets": [ [ 54, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036429" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "multiple sclerosis" ], "offsets": [ [ 45, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026769" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "exercise" ], "offsets": [ [ 95, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015259" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 166, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 180, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700566.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "exercise tolerance" ], "offsets": [ [ 95, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162521" } ] } ]
[]
[]
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DerNervenarzt.90700587.eng.abstr
DerNervenarzt.90700587.eng.abstr
[ { "id": "DerNervenarzt.90700587.eng.abstr-passage-0", "type": "abstract", "text": [ "Lithium is still regarded as the first choice substance in the prophylactic treatment of bipolar disorder . However , approximately one third of patients with a \" classic \" course of bipolar affective disorder do not adequately respond to lithium prophylaxis . The introduction of carbamazepine and valproic acid allowed a more differential syndrome- and course-orientated approach to the prophylactic treatment of bipolar disorder for the first time . However , about 10 to 20 percent of patients still remain refractory to standard regimes . Therefore , criteria for resistance to prophylactic treatment have to be further established . It has been suggested that at least two adequate trials of more than 12 months duration with sufficient drug blood levels have to be performed before refractoriness should be assumed . A severe subtype of affective disorder with poor response to lithium and other treatment approaches is a rapid cycling course which is characterised by at least four affective episodes per year . Here we present an overview of the currently available alternatives for prophylactic treatment , i.e. anticonvulsants , combination treatment , adjunctive thyroxine , calcium channel blockers , and more experimental approaches for treating refractory bipolar disorder patients . Suggestions for optimizing the prophylactic treatment of bipolar disorder are summarized in an algorithm ." ], "offsets": [ [ 0, 1405 ] ] } ]
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"DerNervenarzt.90700587.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "bipolar disorder" ], "offsets": [ [ 89, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005586" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 145, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 201, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "lithium" ], "offsets": [ [ 239, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023870" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 247, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "affective disorder" ], "offsets": [ [ 191, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525045" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "bipolar affective disorder" ], "offsets": [ [ 183, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005586" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "carbamazepine" ], "offsets": [ [ 281, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006949" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 308, 312 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "syndrome-" ], "offsets": [ [ 341, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "prophylactic" ], "offsets": [ [ 389, 401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009653" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 402, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 423, 431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 446, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "valproic acid" ], "offsets": [ [ 299, 312 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042291" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "bipolar 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"offsets": [ [ 596, 605 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 743, 747 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 748, 753 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 854, 862 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "lithium" ], "offsets": [ [ 885, 892 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023870" } ] }, { "id": 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"db_name": "UMLS", "db_id": "C0003286" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1152, 1161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "thyroxine" ], "offsets": [ [ 1175, 1184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040165" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "calcium" ], "offsets": [ [ 1187, 1194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006675" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t7", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 1279, 1287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t8", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1288, 1296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t9", "type": "umlsterm", "text": [ "calcium channel" ], "offsets": [ [ 1187, 1202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006685" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t10", "type": "umlsterm", "text": [ "bipolar disorder" ], "offsets": [ [ 1271, 1287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005586" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s8-t11", "type": "umlsterm", "text": [ "calcium channel blockers" ], "offsets": [ [ 1187, 1211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006684" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "Suggestions" ], "offsets": [ [ 1299, 1310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038659" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "prophylactic" ], "offsets": [ [ 1330, 1342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009653" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1343, 1352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 1364, 1372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "algorithm" ], "offsets": [ [ 1394, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002045" } ] }, { "id": "DerNervenarzt.90700587.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "bipolar disorder" ], "offsets": [ [ 1356, 1372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005586" } ] } ]
[]
[]
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DerNervenarzt.90700600.eng.abstr
DerNervenarzt.90700600.eng.abstr
[ { "id": "DerNervenarzt.90700600.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective : Alterations of motor phenomena are observable clinical phenomena of depressed patients . In addition to cognitive and emotional disturbances , motor dysfunctions are frequent psychopathological features which relate to neurobiological mechanisms of depression . Specific functions of various motor domains , pathophysiological concepts , and relevance of motor functions for diagnosis and prognosis of depression are summarized . Methods : The contemporary literature regarding clinical and research aspects of differential diagnosis , treatment response and pathophysiology as well as the current knowledge regarding objective measures of motor signs in depression are reviewed . Results : Alterations in motility ( gross motor activity ) , locomotion , gestures , mimic , speech characteristics , and tremor are relevant for diagnosis , therapy and prognosis of depression . A large body of literature exists regarding qualitative , indirect measures of motor phenomena and quantitative analysis of motility . Only few unidimensional studies exist in respect to locomotion , gait and tremor in depression . The low correlation between physiological and clinical features may be due to methodological issues . Whereas most publications investigate motor functions indirectly using different functional coding and classification systems , only few studies report direct , physical , characteristics ( kinematics ) of motor phenomena in depression . Conclusions : Existing concepts do not clarify the relation of psychological and somatic components of motor signs . Agitation and retardation should be analyzed as multidimensional and independent variables . New psychometric instruments for documentation of motor phenomena in depression need further evaluation . Application of current technology and quantitative movement analysis may yield further insights in pathophysiological mechanisms and therapeutic strategies and represent important aspects of neurobiological research of depression ." ], "offsets": [ [ 0, 2008 ] ] } ]
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DerNervenarzt.90700613.eng.abstr
DerNervenarzt.90700613.eng.abstr
[ { "id": "DerNervenarzt.90700613.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Gait characteristic and muscle power are often described in the clinical literature but with little empirical support . We assessed some parameters of gait and muscle power using simple and standardized methods within a framework based principally on classic clinical observations of depression . Method : 20 depressed inpatients were examined with standard tests of isometric muscle power and gait parameters , which measure step length , average walking speed , maximal walking speed , and three-minute walk distance . The results were compared with those of 20 matched healthy controls . The examination procedure was repeated after a three week period of inpatient treatment and significant symptomatic improvement . Results : As predicted by our hypothesis depressed patients ' muscle power and gait characteristics differed clearly from normal controls . Significant improvements after 3 weeks of inpatient treatment were found above all in extension of the knee and extension of the elbow tests as well as in all measures of our gait analysis . However , all gait parameters still differed significantly from those of healthy controls . Conclusions : Using simple but reliable tests which were used for the first time in psychiatry we examined certain relationships between depression and motor function in a moderately to severely depressed inpatient sample ." ], "offsets": [ [ 0, 1380 ] ] } ]
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DerNervenarzt.90700620.eng.abstr
DerNervenarzt.90700620.eng.abstr
[ { "id": "DerNervenarzt.90700620.eng.abstr-passage-0", "type": "abstract", "text": [ "The objective of this study was to investigate the relationship between the effect of sleep deprivation , recovery and regional brain perfusion in patients with major depression . Regional cerebral blood flow was assessed by 99mTc-HMPAO-SPECT before and after sleep deprivation in fourteen medicated patients . Three of the patients underwent a follow-up measurement after clinical recovery and with an unchanged antidepressant medication . Before sleep deprivation the responding patients had a significantly higher anterior cingulate perfusion than the nonresponding patients , that normalized after sleep deprivation . Cingulate perfusion uniquely differentiated eventual treatment response from non-responders , as perfusion in no other region under study discriminated the two groups . At baseline all patients revealed hypoperfusion in the left prefrontal cortex when compared to the right side , which was not affected by sleep deprivation , whereas prefrontal hypoperfusion was reversible upon remission . These findings are in agreement with previous PET investigations and provide evidence for cingulate and prefrontal dysfunction associated with depression , that are reversible by successful treatment and may represent state markers ." ], "offsets": [ [ 0, 1247 ] ] } ]
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[]
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DerNervenarzt.90700627.eng.abstr
DerNervenarzt.90700627.eng.abstr
[ { "id": "DerNervenarzt.90700627.eng.abstr-passage-0", "type": "abstract", "text": [ "We investigated time use of persons assigned to seven groups on the basis of psychiatric diagnoses : ( a ) no dementia or depression symptoms , ( b ) individuals with dementia symptoms but no DSM-III-R-diagnosis , ( c ) individuals with dementia according to DSM-III-R , ( d ) individuals with depression symptoms but no diagnosis , ( e ) individuals with depression not further specified ( NFS ) , ( f ) individuals with depression according to DSM-III-R , and ( g ) individuals with symptoms of both dementia and depression . In general , time-use parameters were similar across the groups . As expected , however , we found differences in specific dimensions . Demented and depressed individuals differed from others with respect to the duration of pas- sive phases and receptive leisure . Instrumental activities , active leisure , length of the waking day , and time spent alone were indicators with differential validity regarding dementia diagnoses - partly even after controlling for physical morbidity . Moreover , we were able to differentiate between dementia and depression on the basis of instrumental activities after controlling for physical morbidity ." ], "offsets": [ [ 0, 1168 ] ] } ]
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[]
[]
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DerNervenarzt.90700637.eng.abstr
DerNervenarzt.90700637.eng.abstr
[ { "id": "DerNervenarzt.90700637.eng.abstr-passage-0", "type": "abstract", "text": [ "A number of studies has shown a significant relationship between life events/life conditions and depression . However , there is only a small number of studies investigating the effect of life events/life conditions in patients with severe depression from the endogenous subtype . The results are inconsistent . The present study examines the significance of the patients ' life events/life conditions for the two year outcome of the illness in a prospective study with assessments every three months . Patients are compared to healthy controls with regard to the period three months prior to the admission to the hospital at the index episode . The results confirm the importance of life events and life conditions for the long term outcome of depressed patients with endogenous subtype respectively severe major depression in-patients . Relapsers show considerably more undesirable life conditions than non-relapsers three to six months prior to their relapse . Depressed patients indicate significantly more undesirable life events and life conditions and fewer desirable life conditions in comparison to the control group for the time span three months prior to their hospitalisation . Clinical implications are discussed ." ], "offsets": [ [ 0, 1227 ] ] } ]
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[]
[]
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DerNervenarzt.90700645.eng.abstr
DerNervenarzt.90700645.eng.abstr
[ { "id": "DerNervenarzt.90700645.eng.abstr-passage-0", "type": "abstract", "text": [ "The debate on passive and active euthanasia has met a controversial echo both in the German-speaking media and in professional publications within recent years . This discussion , however , largely excluded mentally ill patients . Also , euthanasia advocacy groups have usually distanced themselves from euthanasia in psychiatric patients . We report here two cases from our hospital in which in-patients with affective disorders committed assisted suicide during a hospital pass . We discuss these events under the assumption that these are cases of questionable active euthanasia in mentally ill patients whose judgement was considerably compromised by their disorder ." ], "offsets": [ [ 0, 671 ] ] } ]
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[]
[]
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DerNervenarzt.90700657.eng.abstr
DerNervenarzt.90700657.eng.abstr
[ { "id": "DerNervenarzt.90700657.eng.abstr-passage-0", "type": "abstract", "text": [ "If patients who need electroconvulsive therapy are unable to consent , it is necessary to gain the guardian's permission to carry out the treatment . It remains unclear if , due to possible side effects , it is necessary to gain an additional approval from the Guardianship Court according to § 1904 of German Civil Code ( BGB ) . The high court of Hamburg ( Landgericht Hamburg ) decided that legal permission is necessary as a result of the risk of persisting retrograde amnesia and the ensuing danger of permanent damage to the patient's health . This paper points out however , that electroconvulsive therapy , even considering the contraindications , is a safe and effective treatment for depression and schizophrenic psychoses . Application of unilateral short-pulse stimulation reduces the frequency and intensity of cognitive side effects . In particular , retrograde amnesia is very rare with regard to frequency and intensity and is negligible when compared with the dangers of the illness itself . There- fore , it is not necessary to apply for approval from the Guardianship Court ." ], "offsets": [ [ 0, 1094 ] ] } ]
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[]
[]
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DerNervenarzt.90700679.eng.abstr
DerNervenarzt.90700679.eng.abstr
[ { "id": "DerNervenarzt.90700679.eng.abstr-passage-0", "type": "abstract", "text": [ "For the ussage as blood substitutes perfluorocarbons ( PFC ) have been developed as artificial oxygen carriers . In addition they may have potency for protective use in ischemic tissue . Formulation improvement achieved higher oxygen carrying capacity and better compatibility than the first generation of PFC . Preclinical studies have been performed in animal heart and brain . Former and progressed emulsification for intravascular use have been investigated for infarction and reperfusion injury . This investigations are reviewed and the potencies for the use of PFC in neurology , neurosurgery , diagnostics today and in the future are emphasized ." ], "offsets": [ [ 0, 654 ] ] } ]
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[]
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"DerNervenarzt.90700679.eng.abstr-s6-t1", "arg2_id": "DerNervenarzt.90700679.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerNervenarzt.90700679.eng.abstr-s6-r5-t4.1-t3.1", "type": "issue_in", "arg1_id": "DerNervenarzt.90700679.eng.abstr-s6-t4", "arg2_id": "DerNervenarzt.90700679.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerNervenarzt.90700679.eng.abstr-s6-r6-t3.2-t1.1", "type": "method_of", "arg1_id": "DerNervenarzt.90700679.eng.abstr-s6-t3", "arg2_id": "DerNervenarzt.90700679.eng.abstr-s6-t1", "normalized": [] } ]
DerNervenarzt.90700688.eng.abstr
DerNervenarzt.90700688.eng.abstr
[ { "id": "DerNervenarzt.90700688.eng.abstr-passage-0", "type": "abstract", "text": [ "Paraneoplastic neurologic syndromes ( PNS ) are rare disorders of the nervous system that cannot be ascribed to metatastases or to destruction of vital systemic organs by the tumor or its treatment . Most frequently , PNS occur in association with small-cell lung , breast or ovarian carcinomas . The most frequent PNS is Lambert-Eaton myasthenic syndrome , which at the same time has the highest predictive value concerning an underlying carcinoma . PNS have been classified mostly under anatomical aspects but now are increasingly categorized according to specific antibodies . In certain neurologic syndromes ( sensible and autonomic neuropathy , cerebellitis , limbic encephalitis , Opsoclonus-Myoclonus syndrome , Stiff-man syndrome , neuromyotonia , subacute amaurosis ) specific autoantibodies are highly predictive for a neoplasm . Pathogenic relevance of these autoantibodies has been demonstrated only for antibodies against ( 1 ) voltage gated calcium channels ( VGCC ) in Lambert-Eaton myasthenic syndrome , ( 2 ) voltage gated potassium channels ( VGKC ) in neuromyotonia , and ( 3 ) recoverin in cancer associated retinopathy . The present article deals with the neurological symptoms of PNS , associated tumors , and the relevance of specific antibodies for the diagnosis and pathogenesis of PNS ." ], "offsets": [ [ 0, 1312 ] ] } ]
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[ "treatment" ], "offsets": [ [ 188, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "nervous system" ], "offsets": [ [ 70, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027763" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "PNS" ], "offsets": [ [ 218, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206417" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 231, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "lung" ], "offsets": [ [ 259, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024109" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 266, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 284, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "PNS" ], "offsets": [ [ 315, 318 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206417" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 347, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 376, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 408, 413 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 439, 448 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "myasthenic syndrome" ], "offsets": [ [ 336, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022972" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "Lambert-Eaton myasthenic syndrome" ], "offsets": [ [ 322, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022972" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "PNS" ], "offsets": [ [ 451, 454 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206417" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "anatomical" ], "offsets": [ [ 489, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 567, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 602, 611 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "encephalitis" ], "offsets": [ [ 672, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014038" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 708, 716 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "Stiff-man" ], "offsets": [ [ 719, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086418" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 729, 737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "neuromyotonia" ], "offsets": [ [ 740, 753 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242287" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "neuromyotonia" ], "offsets": [ [ 740, 753 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027125" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t8", "type": "umlsterm", "text": [ "amaurosis" ], "offsets": [ [ 765, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376288" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t9", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 786, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t10", "type": "umlsterm", "text": [ "neoplasm" ], "offsets": [ [ 829, 837 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t11", "type": "umlsterm", "text": [ "Opsoclonus-Myoclonus syndrome" ], "offsets": [ [ 687, 716 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0393626" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s5-t12", "type": "umlsterm", "text": [ "Stiff-man syndrome" ], "offsets": [ [ 719, 737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085292" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 870, 884 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 916, 926 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "calcium" ], "offsets": [ [ 955, 962 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006675" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 1009, 1017 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "potassium" ], "offsets": [ [ 1040, 1049 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032821" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "neuromyotonia" ], "offsets": [ [ 1071, 1084 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242287" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "neuromyotonia" ], "offsets": [ [ 1071, 1084 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027125" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "recoverin" ], "offsets": [ [ 1097, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0140116" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t9", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 1110, 1116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t10", "type": "umlsterm", "text": [ "retinopathy" ], "offsets": [ [ 1128, 1139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035309" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t11", "type": "umlsterm", "text": [ "calcium channels" ], "offsets": [ [ 955, 971 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006685" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t12", "type": "umlsterm", "text": [ "myasthenic syndrome" ], "offsets": [ [ 998, 1017 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022972" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t13", "type": "umlsterm", "text": [ "potassium channels" ], "offsets": [ [ 1040, 1058 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032824" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s6-t14", "type": "umlsterm", "text": [ "Lambert-Eaton myasthenic syndrome" ], "offsets": [ [ 984, 1017 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022972" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 1190, 1198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "PNS" ], "offsets": [ [ 1202, 1205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206417" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 1219, 1225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerNervenarzt.90700688.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "antibodies" ], "offsets": 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[]
[]
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DerNervenarzt.90700702.eng.abstr
DerNervenarzt.90700702.eng.abstr
[ { "id": "DerNervenarzt.90700702.eng.abstr-passage-0", "type": "abstract", "text": [ "In recent years , a more precise neurobiological knowledge has been gained concerning the various cellular parameters which mediate successful peripheral nerve regeneration , and also those which prevent repair of damaged nerve fibre pathways following traumatic injury to the the central nervous system ( CNS ) . On this basis , a range of experimental therapeutical approaches for promoting axonal regeneration and functional recovery after spinal cord injury have been developed in animal models . Such intervention strategies focus on the molecular inactivation of glial-associated growth-inhibitory factors and on the application of trophic molecules and cellular substrates which enhance the postlesional regenerative potential of intrinsic CNS neurons . At the present , these experimental therapies cannot be transferred to the clinical situation for the treatment of spinal cord injured patients . This overview briefly summarizes current progress in the neurobiology of spinal cord trauma , the main findings of which are discussed in the light of clinical expectations ." ], "offsets": [ [ 0, 1081 ] ] } ]
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DerNervenarzt.90700714.eng.abstr
DerNervenarzt.90700714.eng.abstr
[ { "id": "DerNervenarzt.90700714.eng.abstr-passage-0", "type": "abstract", "text": [ "In four patients presenting with acute nontraumatic intracerebral or intraspinal hemorrhage , T2*-weighted gradient-echo MRI showed numerous residual hemosiderin deposits due to old intracerebral hemorrhages that were missed on initial CT and spin-echo MRI . The demonstration of additional chronic bleedings and their anatomical distribution provided important diagnostic information . In a hypertensive patient , the hemosiderin deposits were most pronounced within deep brain structures suggesting hypertensive cerebral microangiopathy . In a second patient , the cortico-subcortical distribution of the hemorrhages was typical of cerebral amyloid angiopathy . In a third patient , the diffuse distribution including spinal bleeding , the marked calcification , and the characteristic appearance on spin-echo MRI were consistent with multiple cavernomas . In another patient with cerebral and spinal hemorrhage , T2*-weighted gradient-echo MRI revealed new subclinical hemorrhages during follow-up . Based on these findings , we recommend that T2*-weighted gradient-echo MRI of the brain should be performed in all patients with acute intracranial and spinal bleedings ." ], "offsets": [ [ 0, 1173 ] ] } ]
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DerNervenarzt.90700723.eng.abstr
DerNervenarzt.90700723.eng.abstr
[ { "id": "DerNervenarzt.90700723.eng.abstr-passage-0", "type": "abstract", "text": [ "Abstract Mitoxantrone is an anthracenedione antineoplastic agent that has recently been shown to be effective in ameliorating disease activity in multiple sclerosis ( MS ) as indicated by clinical and MRI data . However , the role of mitoxantrone in escalating treatment of patients with frequent and severe relapses and with rapid progression of disability is less clear . In this retrospective analysis we report on 15 patients with severe relapsing-remitting ( 9 patients ) and secondary progressive MS with superimposed exacerbations ( 6 patients ) treated openlabeled with mitoxantrone in our Clinical Research Group from July 1994 to October 1998. Eleven of these patients ( 73% ) were treated with azathioprine , interferon-beta-1b or cyclophosphamide before . The patients received mitoxantrone over a period of at least 12 months ( 19 +/- 6 months ) with a single dose of 10 mg/m2 monthly for the first three months . Thereafter , infusions were repeated every 3 months ( total dose 141 mg +/- 45 mg ) . The annual relapse rate could be significantly reduced from 3,0 +/- 1,5 in the year before therapy to 0,5 +/- 0,5 during therapy . Nine patients ( 60% ) were stabilised , while four patients ( 27% ) showed an improvement of disability . The treatment was well tolerated with only minor side effects . These results although retrospectively obtained confirm previous trials showing that mitoxantrone may be useful in MS patients with frequent and severe exacerbations and/or a rapidly progressive course of the disease who have had other immunomodulatory medication ." ], "offsets": [ [ 0, 1579 ] ] } ]
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"umlsterm", "text": [ "MRI" ], "offsets": [ [ 201, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "antineoplastic agent" ], "offsets": [ [ 44, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003392" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "multiple sclerosis" ], "offsets": [ [ 146, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026769" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 226, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mitoxantrone" ], "offsets": [ [ 234, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026259" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 261, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 274, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "relapses" ], "offsets": [ [ 308, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035020" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "retrospective" ], "offsets": [ [ 382, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 396, 404 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 421, 429 ] ], 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{ "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "October" ], "offsets": [ [ 640, 647 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029279" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 670, 678 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "azathioprine" ], "offsets": [ [ 705, 717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004482" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t12", "type": "umlsterm", "text": [ "cyclophosphamide" ], "offsets": [ [ 742, 758 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010583" } ] }, { "id": "DerNervenarzt.90700723.eng.abstr-s3-t13", "type": "umlsterm", "text": [ "Clinical Research" ], "offsets": [ [ 598, 615 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008972" 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[]
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