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DerNervenarzt.70680990.eng.abstr
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DerNervenarzt.70680990.eng.abstr
|
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"id": "DerNervenarzt.70680990.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hemiballism is a rare hyperkinetic disorder which is characterized by irregular vigorous rotatory movements of the limbs of one side of the body . The disabling and exhausting movements with their high risk of severe injuries require an acute drug treatment . However , there are no common guidelines for the treatment of this disorder . Therefore we reviewed the available literature to establish a concept for a rational symptomatic drug treatment . Furthermore , own observations in 6 patients with hemiballism of different origins are reported ."
],
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[
0,
549
]
]
}
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"id": "DerNervenarzt.70680990.eng.abstr-s1-t3",
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"movements"
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"id": "DerNervenarzt.70680990.eng.abstr-s5-t3",
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[] |
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DerNervenarzt.70681002.eng.abstr
|
DerNervenarzt.70681002.eng.abstr
|
[
{
"id": "DerNervenarzt.70681002.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 47 year old male patient with Miller-Fisher-syndrome did not respond to treatment with plasmapheresis and intravenous high dose 7 S immune globulins . Only cerebrospinal fluid pheresis , administered as final alternative , lead to definite improvement and cure ."
],
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[] |
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DerNervenarzt.70681004.eng.abstr
|
DerNervenarzt.70681004.eng.abstr
|
[
{
"id": "DerNervenarzt.70681004.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Given the relentless progression of amytrophic lateral sclerosis ( ALS ) and the lack of causative therapy , breaking the news to ALS patients and their families is a daunting task for any physician . Obviously , such a task cannot be standardized . However , it is now recognized to be the first and one of the most sensitive and important steps in palliative care . Information should be offered in a stepwise fashion , in the presence of the patient's family . All questions from the patient should be discussed openly , with emphasis on the positive aspects . Available therapeutic options should be reviewed , pointing out the fact that all symptoms of ALS can be alleviated by palliative therapy . At the onset of dyspneic symptoms , the terminal phase of the disease and the option of mechanical ventilation should be discussed ."
],
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[
0,
836
]
]
}
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[] |
[] |
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DerNervenarzt.80690001.eng.abstr
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DerNervenarzt.80690001.eng.abstr
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"Approximately one-third of all pregnant women take psychotropic drugs at least once during pregnancy . At the same time , there are no preparations on the market that can be considered entirely appropriate for expectant mothers . The effects of psychopharmacological therapies have exclusively been discussed in the context of their risk during the first trimester . However , treatment after this phase is not absolutely without risk , and it is striking that there are grave differences between various substances . There are currently controversial discussions going on in literature as far as the teratogenicity of lithium is concerned , especially during the formation of the heart . It is suggested that the risk for congenital malformations is increased after intrauterine lithium exposure , whereas such a risk cannot be proved for most of the antidepressants and neuroleptics . Still , it should be noted that psychopharmacology is not harmless even after the organogenesis , as intrauterine exposure during the 2nd and 3rd trimester can lead to postnatal complications . For example , floppy-infant syndrome after taking benzodiazepines , and the extrapyramidal-motor effects on the newborn after neuroleptic therapy during pregnancy should be mentioned ."
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DerNervenarzt.80690010.eng.abstr
|
DerNervenarzt.80690010.eng.abstr
|
[
{
"id": "DerNervenarzt.80690010.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Whilst the incidence of psychiatric disorders decreases during pregnancy , the risk during the postpartum period increases significantly , often leading to the necessity of psychopharmacological intervention during the puerperium , and subsequently during lactation and breast-feeding . The necessity for lithium prophylaxis in manic-depressive women after childbirth has been identified , and it is recommended that weaning rather than omission of psychopharmacological treatment is preferable during the puerperium ."
],
"offsets": [
[
0,
518
]
]
}
] |
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106,
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},
{
"id": "DerNervenarzt.80690010.eng.abstr-s1-t7",
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"puerperium"
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219,
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},
{
"id": "DerNervenarzt.80690010.eng.abstr-s1-t8",
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256,
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"id": "DerNervenarzt.80690010.eng.abstr-s1-t9",
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24,
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]
},
{
"id": "DerNervenarzt.80690010.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"postpartum period"
],
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[
95,
112
]
],
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{
"db_name": "UMLS",
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}
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},
{
"id": "DerNervenarzt.80690010.eng.abstr-s2-t1",
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"lithium"
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"id": "DerNervenarzt.80690010.eng.abstr-s2-t2",
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313,
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},
{
"id": "DerNervenarzt.80690010.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"women"
],
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[
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"db_id": "C0043210"
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},
{
"id": "DerNervenarzt.80690010.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"childbirth"
],
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"id": "DerNervenarzt.80690010.eng.abstr-s2-t5",
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DerNervenarzt.80690027.eng.abstr
|
DerNervenarzt.80690027.eng.abstr
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[
{
"id": "DerNervenarzt.80690027.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the Berlin Aging Study ( BASE ) an age and gender stratified sample of 516 persons aged 70 to over 100 was assessed by means of the semi-structured GMS-A interview , the CES-D-self-rating scale and the Hamiltion-Depression-observer-rating scale . Prevalence rates were 4,8% for Major Depression , 9,1% for all DSM III-R specified depressive disorders and 26,9% of subthreshold depression was included . There was no increase in prevalence rates with age but an increase in scores on the self rating CES-D . The prevalence rates for DSM III-R specified depression in females was 10,3% and almost double that of men ( 5,6% ) . Depressed persons do not show significant cognitive impairment as measured with the MMSE in comparison to controls . As compared to the total sample higher prevalence rates of overall depression were seen in persons with multimorbidity ( 36,8% ) and lower rates in married persons . 13,2% of the elderly talked about feeling tired with life , 7,9% had thoughts about death and 1,2% reported suicidal ideation , which was closely linked to depressive disorders . In 44% of depressed cases undertreatment was observed . Only 6% got Antidepressants but 40% benzodiazepines ."
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DerNervenarzt.80690038.eng.abstr
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DerNervenarzt.80690038.eng.abstr
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"id": "DerNervenarzt.80690038.eng.abstr-passage-0",
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"Subjective time-experience and objective time-estimation were examined in 20 endogenous , 20 neurotic depressives , and 15 healthy volunteers . Subjective experience of past and anticipated future time was more extended in both depressive groups than in healthy controls . Objective time estimation differed between depressives and controls concerning relatively long time spans whereas very short time spans were correctly estimated also by depressives . There were no significant differences between endogenous and neurotic depressives . The perception of extended time normalized during treatment . The depressives ' time perception , differences correlated with the extent of depressive psychopathological symptoms and - to a lesser degree - with retardation . The findings support the hypotheses of anthropological phenomenology concerning disturbed time perception and estimation in depressives . Amelioration of experienced time-extension in intentionally structured time spans compared to empty time spans suggests psychotherapeutic consequences in the sense of Lewinsohn ."
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[] |
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DerNervenarzt.80690046.eng.abstr
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DerNervenarzt.80690046.eng.abstr
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"id": "DerNervenarzt.80690046.eng.abstr-passage-0",
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"A prospektive multidimensional study with 71 remitted bipolar outpatients ( 37 bipolars without , 34 with psychotic symptoms during acute mania ) was made to assess relevant influential factors on relapse and readmission to hospital : characteristic data of previous course , psycho ( patho ) logical state and personality after remission , personality disorders , and ways of coping . In the course of the 5 years after the first examination , 48% of the patients were readmitted , 60% of them because of a ( schizo ) manic state . The study confirms the prognostic relevance of past course , e.g. number of previous episodes and mania-quotient . A further risk-factor are residual psychopathological alterations which persist after remission ( \" negative symptoms \" of strictly bipolars , increased vulnerability for dynamic derailment for the bipolars with psychotic symptoms ) . Patients with \" syntonic \" personality in the free interval suffered less relapses . The relevance of other personality traits differed in the diagnostic subgroups of nonpsychotic and psychotic bipolars . Active coping was positively correlated with staying healthy , but the correlations were weak ."
],
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[] |
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] |
DerNervenarzt.80690053.eng.abstr
|
DerNervenarzt.80690053.eng.abstr
|
[
{
"id": "DerNervenarzt.80690053.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Grief and depressive syndrome belong to normal reaction by parents after a sudden infant death ( SID ) . In the following we report on two cases from the point of view of psychiatry and forensic medicine in which , subsequent to SID , mothers reacted with extremly grave depression and occused themselves of having killed the child . Furthermore , some recommendiations are given for the care of parents affected ."
],
"offsets": [
[
0,
414
]
]
}
] |
[
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Grief"
],
"offsets": [
[
0,
5
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018235"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"syndrome"
],
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[
21,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"parents"
],
"offsets": [
[
59,
66
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030551"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"infant"
],
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[
82,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021270"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"death"
],
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[
89,
94
]
],
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{
"db_name": "UMLS",
"db_id": "C0011065"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"SID"
],
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[
97,
100
]
],
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{
"db_name": "UMLS",
"db_id": "C0038644"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"depressive syndrome"
],
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[
10,
29
]
],
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{
"db_name": "UMLS",
"db_id": "C0086133"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"sudden infant death"
],
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[
75,
94
]
],
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{
"db_name": "UMLS",
"db_id": "C0038644"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"psychiatry"
],
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171,
181
]
],
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{
"db_name": "UMLS",
"db_id": "C0033873"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"medicine"
],
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[
195,
203
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025118"
},
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"SID"
],
"offsets": [
[
229,
232
]
],
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{
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}
]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"mothers"
],
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235,
242
]
],
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]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t5",
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271,
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],
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},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t6",
"type": "umlsterm",
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"child"
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326,
331
]
],
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},
{
"id": "DerNervenarzt.80690053.eng.abstr-s2-t7",
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},
{
"id": "DerNervenarzt.80690053.eng.abstr-s3-t1",
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"care"
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388,
392
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],
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]
},
{
"id": "DerNervenarzt.80690053.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"parents"
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396,
403
]
],
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{
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"db_id": "C0030551"
}
]
}
] |
[] |
[] |
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] |
DerNervenarzt.80690066.eng.abstr
|
DerNervenarzt.80690066.eng.abstr
|
[
{
"id": "DerNervenarzt.80690066.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Approximately 60% of patients with major depression disorder show a beneficial response to total sleep deprivation ( TSD ) , but the positive effect of TSD is short , and naps or the following night's sleep destroy it . Various methods have been tried to stabilize the positive sleep-deprivation effect . A consecutive 1-week advance in the sleep phase stabilized mood in more than 50% of the sleep-deprivation responders . We examined 40 male patients with major depression who in addition to medical treatment took part in a phase advance study to prove possible synergistic effects . About 60% of the patients showed positive mood stabilization after 1-week of treatment when the patients were sleep-deprivation responders . These results support data from other groups ."
],
"offsets": [
[
0,
774
]
]
}
] |
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] |
[] |
[] |
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] |
DerNervenarzt.80690070.eng.abstr
|
DerNervenarzt.80690070.eng.abstr
|
[
{
"id": "DerNervenarzt.80690070.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Between January 1995 and June 1996 , 24 inpatients at our hospital ( mean age 55.6 years ) were treated with electroconvulsive therapy ( ECT ) . Clinical improvement was observed in 80% of the patients , including those without risk factors ( NRG , n=16), as well as those with concomitant cardiovascular diseases ( RG , n=8). During a mean period of observation of 224 days after the end of ECT 7 patients ( 35% ) relapsed . The rate of relapse was higher in RG than in NRG patients ( 57.1 vs 23.1% ) . In all cases ECT was well tolerated ; 285 applications of ECT did not result in mortality or persistent morbidity . However , RG patients may be at increased risk for the development of minor cardiovascular complications , which were noted in three RG patients ( 37.5% ) , but only in one patient ( 6.2% ) in the NRG ( Fisher's test , P=0.09). Taken together , our results demonstrate that ECT is a safe treatment regimen for depression even in medically ill patients of old age ."
],
"offsets": [
[
0,
984
]
]
}
] |
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"id": "DerNervenarzt.80690070.eng.abstr-s1-t5",
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"id": "DerNervenarzt.80690070.eng.abstr-s1-t7",
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"id": "DerNervenarzt.80690070.eng.abstr-s1-t8",
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"id": "DerNervenarzt.80690070.eng.abstr-s2-t2",
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"id": "DerNervenarzt.80690070.eng.abstr-s2-t4",
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"id": "DerNervenarzt.80690070.eng.abstr-s2-t8",
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"id": "DerNervenarzt.80690070.eng.abstr-s4-t4",
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}
] |
[] |
[] |
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DerNervenarzt.80690076.eng.abstr
|
DerNervenarzt.80690076.eng.abstr
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"id": "DerNervenarzt.80690076.eng.abstr-passage-0",
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"A report is given about a 57-year-old woman with a major depression , melancholic subtype . While under amitriptyline 75 mg/day no adverse effects were observed , immediately after increasing the dosage to 150 mg/day \" head spasms \" with headache , profuse sweating and arterial hypertension appeared . The diagnosis of a pheochromcytoma was made and adrenalectomy was performed . This is the first case of unmasking a pheochromcytoma by amitriptyline ; furthermore a connexion was found with the daily dosage of the antidepressant ."
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] |
[] |
[] |
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DerNervenarzt.80690093.eng.abstr
|
DerNervenarzt.80690093.eng.abstr
|
[
{
"id": "DerNervenarzt.80690093.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Swiss physician Johann Jakob Wepfer has been hailed as the author of the \" classic \" modern treatise on apoplexy ( 1658 ) . His name is known because he demonstrated that apoplexy resulted from brain hemorrhage or occlusive diseases of the vessels . A re-examination of the original text , however , reveals surprising evidence that essential parts of Wepfer's book have been neglected so far . These chapters demonstrate that Wepfer's medical thinking is deeply rooted in pre-modern concepts , e.g. Galenic theories of brain function and iatrochemical concepts of disease . A re-evaluaton of the non-modern elements of Wepfer's treatise leads to a better understanding of the whole text ."
],
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0,
693
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}
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"id": "DerNervenarzt.80690093.eng.abstr-s2-t2",
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DerNervenarzt.80690099.eng.abstr
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DerNervenarzt.80690099.eng.abstr
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[] |
[] |
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DerNervenarzt.80690117.eng.abstr
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DerNervenarzt.80690117.eng.abstr
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[] |
[] |
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DerNervenarzt.80690127.eng.abstr
|
DerNervenarzt.80690127.eng.abstr
|
[
{
"id": "DerNervenarzt.80690127.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Juvenile myoclonic epilepsy ( JME ) was de-scribed electroclinically by Janz and Christian in 1957 and consists of myoclonic jerks in varying combination with the absence of seizures and generalized tonic-clonic seizures , a typical circadian distribution on awakening , sleep deprivation , alcohol consumption and flickering stimuli as characteristic precipitating factors , typical EEG abnormalities with generalized epileptiform discharges , normal physical and neuroradiological findings , and often a family history of epilepsy . Although the misdiagnosis of this well-classified and easily treatable syndrome is supposed to occur rarely in Germany , we retrospectively investigated how often the wrong initial classification had been made among patients who were finally treated in our outpatient epilepsy unit . Between 1993 and 1995 , 30 patients with a typical JME-like symptom constellation were identified who had been misdiagnosed initially . In all patients , localization-related epilepsy had been classified , although regional EEG abnormalities were rare ( n=5). All patients reported the typical circadian distribution , abnormal neuroradiological findings were absent , and typical EEG abnormalities were present in all cases . Under treatment with appropiate antiepileptic drugs 97% of the patients became almost completely seizure-free . Even 40 years after the first description of the syndrome , JME is an underdiagnosed illness . The generally positive course underlines the importance of its correct identification ."
],
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[
0,
1540
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}
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174,
182
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DerNervenarzt.80690131.eng.abstr
|
DerNervenarzt.80690131.eng.abstr
|
[
{
"id": "DerNervenarzt.80690131.eng.abstr-passage-0",
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"In the etiopathology of tension type headache , vascular and autonomic disorders are discussed . Fifteen patients with chronic tension type headache according to the criteria of the IHS were investigated using the TCD-ergometer-test - a method used to evaluate the myogenic mechanism of cerebrovascular autoregulation - and the results were compared with the findings in fifteen healthy control subjects ."
],
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[
0,
405
]
]
}
] |
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] |
[] |
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DerNervenarzt.80690145.eng.abstr
|
DerNervenarzt.80690145.eng.abstr
|
[
{
"id": "DerNervenarzt.80690145.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and purpose : To test the association of cardiac sources of embolism with territorial type brain infarcts ."
],
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[
0,
118
]
]
}
] |
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"association"
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37,
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{
"id": "DerNervenarzt.80690145.eng.abstr-s1-t2",
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"id": "DerNervenarzt.80690145.eng.abstr-s1-t4",
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"infarcts"
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108,
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]
}
] |
[] |
[] |
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},
{
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"id": "DerNervenarzt.80690145.eng.abstr-s1-r19-t2.1-t3.3",
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] |
DerNervenarzt.80690151.eng.abstr
|
DerNervenarzt.80690151.eng.abstr
|
[
{
"id": "DerNervenarzt.80690151.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Epileptic seizures may alter autonomic functions . This is especially the case with complex focal seizures ( of temporal lobe origin ) and grand mal . Most frequently , such seizures cause ictal tachycardia , sometimes tachypnea , probably caused by the propagation of epileptic discharges to autonomic cerebral structures . Ictal bradycardia and asystole are rare phenomena . However , they may be life threatening . Their differentiation from primary cardiac arrest is possible by the use of ictal EEG and ECG registration . Postictal serum prolactin measurement does not differentiate syncope from seizure . However , a postictal increase of creatine kinase is only measured after epileptic seizures and not after syncope . Treatment of such epileptic seizures includes an optimization of anticonvulsant drug therapy and the implantation of a cardiac demand stimulator . There is growing evidence that ictal asystole is a cofactor in sudden unexplained death in epileptic patients ."
],
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[
0,
985
]
]
}
] |
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{
"id": "DerNervenarzt.80690151.eng.abstr-s1-t1",
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"Epileptic"
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{
"id": "DerNervenarzt.80690151.eng.abstr-s1-t2",
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"text": [
"seizures"
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"id": "DerNervenarzt.80690151.eng.abstr-s1-t3",
"type": "umlsterm",
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"functions"
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{
"id": "DerNervenarzt.80690151.eng.abstr-s1-t4",
"type": "umlsterm",
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"Epileptic seizures"
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"id": "DerNervenarzt.80690151.eng.abstr-s2-t1",
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98,
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"id": "DerNervenarzt.80690151.eng.abstr-s2-t2",
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"origin"
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"id": "DerNervenarzt.80690151.eng.abstr-s2-t3",
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"focal seizures"
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"id": "DerNervenarzt.80690151.eng.abstr-s2-t4",
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"temporal lobe"
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{
"id": "DerNervenarzt.80690151.eng.abstr-s2-t5",
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"text": [
"grand mal"
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"id": "DerNervenarzt.80690151.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"seizures"
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174,
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"id": "DerNervenarzt.80690151.eng.abstr-s3-t2",
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"text": [
"tachycardia"
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195,
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"id": "DerNervenarzt.80690151.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"epileptic"
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"id": "DerNervenarzt.80690151.eng.abstr-s3-t4",
"type": "umlsterm",
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"discharges"
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"id": "DerNervenarzt.80690151.eng.abstr-s4-t1",
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"bradycardia"
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{
"id": "DerNervenarzt.80690151.eng.abstr-s4-t2",
"type": "umlsterm",
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"asystole"
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"life"
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"id": "DerNervenarzt.80690151.eng.abstr-s6-t2",
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"EEG"
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"id": "DerNervenarzt.80690151.eng.abstr-s6-t3",
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"ECG"
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"id": "DerNervenarzt.80690151.eng.abstr-s6-t4",
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"cardiac arrest"
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"id": "DerNervenarzt.80690151.eng.abstr-s7-t1",
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"prolactin"
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553,
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"id": "DerNervenarzt.80690151.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"syncope"
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588,
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{
"id": "DerNervenarzt.80690151.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
"seizure"
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601,
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{
"id": "DerNervenarzt.80690151.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"creatine"
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645,
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{
"id": "DerNervenarzt.80690151.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"kinase"
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{
"id": "DerNervenarzt.80690151.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"epileptic"
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},
{
"id": "DerNervenarzt.80690151.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"seizures"
],
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]
},
{
"id": "DerNervenarzt.80690151.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"syncope"
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[
717,
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DerNervenarzt.80690158.eng.abstr
|
DerNervenarzt.80690158.eng.abstr
|
[
{
"id": "DerNervenarzt.80690158.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 32-year-old female patient who had had a history of complex partial seizures since the age of 14. Phenobarbital was the most effective anticonvulsant drug in this patient . However , the drug treatment was complicated by a phenobarbital-induced exanthematous eruption . Reintroduction of the phenobarbital some years later resulted in a skin rash again ; therefore , treatment with this substance had to be discontinued a second time . Because of the satisfactory antiepileptic efficacy , phenobarbital was introduced a third time using a desen-sitization procedure with increased oral doses , starting with a dose of 1 mg . After a daily dose of 90 mg phenobarbital , on day 6 an exanthematous eruption appeared . The exanthem disappeared parallel to a dose reduction of phenobarbital and with a gradually increasing dosage up to a maintenance dose of 200 mg . Tolerance to the allergic effect of phenobarbital was preserved and the seizure frequency was significantly reduced by phenobarbital monotherapy with a daily dose of 200-175 mg ."
],
"offsets": [
[
0,
1055
]
]
}
] |
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33
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},
{
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{
"id": "DerNervenarzt.80690158.eng.abstr-s1-t4",
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{
"id": "DerNervenarzt.80690158.eng.abstr-s1-t6",
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DerNervenarzt.80690162.eng.abstr
|
DerNervenarzt.80690162.eng.abstr
|
[
{
"id": "DerNervenarzt.80690162.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Subacute encephalopathy with seizures in alcoholics ( SESA syndrome ) is a rare disease entity following chronic alcohol ingestion . It is quite distinct from alcohol withdrawal syndromes , such as delirium , withdrawal seizures or CNS complications of alcohol , such as Wernicke-Korsakow syndrome , central pontine myelinolysis or Marchiafava-Bignami disease , and was proposed in 1981 by Niedermeyer and coworkers . This syndrome consists of multiple neurological deficits , such as hemiparesis or hemianopia , and of recurrent focal and generalized seizures associated with prominent EEG features ( peri-odic lateralized discharges , PLEDs ) . A 72-year-old Caucasian male with chronic alcoholism and an otherwise unremarkable past medical history was admitted to our hospital be-cause of several secondary generalized simple partial seizures . Laboratory investigations revealed elevated levels of gamma-glutamyl-transpeptidase and of mean corpuscular volume . Other laboratory investigations and the CSF examinations on three occasions revealed normal values . Cranial computed and magnetic resonance tomography showed cerebral microangiopathy and generalized atrophy . Despite triple anticonvulsive therapy and an intravenous treatment with acyclovir and thiamine , the epileptic seizures persisted . Several EEGs revealed left parieto-occipital perodic lateralized epileptiform discharges ( PLEDs ) . The patient died of an intercurrent pulmonary infection about 3 months after the onset of symptoms . The described clinical picture resembles the symptoms of SESA syndrome ."
],
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0,
1581
]
]
}
] |
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DerNervenarzt.80690166.eng.abstr
|
DerNervenarzt.80690166.eng.abstr
|
[
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"text": [
"We present a 43-year-old patient who has had up to 15 frontal lobe seizures nightly for 12 years . The patient had no complaints apart from excessive daytime sleepiness . Neurological and psychiatric examination as well as cerebral computed tomograph and magnetic resonance imaging were normal . After sleep deprivation an interictal electro-encephalogram demonstrated a recurrent excess of theta activity over the right frontal and frontopolar area . A cerebral PET study showed diminished glucose metabolism of the right cingular and frontomesial region . The sleep structure was extremely fragmented . There was an excessive reduction of slow-wave sleep and REM sleep . Carbamazepine therapy produced complete seizure control lasting a few weeks , followed by return of up to 8 seizures per night . Vigabatrin as add on therapy diminished the noctural seizures to 1 to 3 per night ."
],
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0,
885
]
]
}
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[] |
[] |
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] |
DerNervenarzt.80690171.eng.abstr
|
DerNervenarzt.80690171.eng.abstr
|
[
{
"id": "DerNervenarzt.80690171.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 70-year old man with acute intermittent porphyria had acute transient bibrachial paresis with moderate contracture of the involved muscles , which showed electrical silence in a conventional electromyographic investigation with surface electrodes placed over the contracted muscle belly ( filter : 20Hz-2 Hz , amplifier 50 µV). Slow finger movements were still possible and showed typical muscle-action potentials . This electroclinical correlation points to myopathic localized dysfunction , perhaps similar to rare case reports with patients haveing metabolic myopathy of McArdle's type ."
],
"offsets": [
[
0,
592
]
]
}
] |
[
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},
{
"id": "DerNervenarzt.80690171.eng.abstr-s1-t3",
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{
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276,
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},
{
"id": "DerNervenarzt.80690171.eng.abstr-s1-t10",
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"amplifier"
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312,
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{
"id": "DerNervenarzt.80690171.eng.abstr-s1-t11",
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{
"id": "DerNervenarzt.80690171.eng.abstr-s1-t12",
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{
"id": "DerNervenarzt.80690171.eng.abstr-s1-t13",
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] |
[] |
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DerNervenarzt.80690180.eng.abstr
|
DerNervenarzt.80690180.eng.abstr
|
[
{
"id": "DerNervenarzt.80690180.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Stroke units are hospital-based special wards aiming at optimal care by a specialized team with an integrated concept for patients with acute strokes . Following the initial neurolo-gical and neuroradiological evaluation , early treatment will be initiated based on the assumed pathophysiology of the stroke . Acute management includes monitoring of physiological , parameters , care by specialized nurses , and early implementation of physiotherapists , speech therapy and occupational therapy . Despite the increased initial costs , the long-term burden for the health system is decreased by shorter hospital stay and reduced morbidity and disability ."
],
"offsets": [
[
0,
654
]
]
}
] |
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[] |
[] |
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DerNervenarzt.80690189.eng.abstr
|
DerNervenarzt.80690189.eng.abstr
|
[
{
"id": "DerNervenarzt.80690189.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Lithium is widely used in the acute and prophylactic treatment of affective disorders . Lithium affects thyroid hormone metabolism via different mechanisms . In patients this leads to a compensatory increase in pituitary thyroid stimulating hormone ( TSH ) which usually maintains the euthyroid status . This is probably the reason for the relatively high prevalence of goitre in lithium-treated patients ; however , the enlargement of the gland is only moderate in most cases . Due to its immunostimulating effects lithium may support the appearance of thyroid autoantibodies and the developement of thyroiditis , which may be the reason for a higher prevalence of hypothyroidism in patients receiving lithium . However , also cases of hyperthyroidism in such patients have been reported repeatedly . Therapeutic recommendations for the treatment of disturbances of thyroid function during lithium treatment are given ."
],
"offsets": [
[
0,
920
]
]
}
] |
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] |
DerNervenarzt.80690204.eng.abstr
|
DerNervenarzt.80690204.eng.abstr
|
[
{
"id": "DerNervenarzt.80690204.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the German mutlicentre ANI study comparing continuous prophylactic treatment with intermittent medication , the social situation of a large sample of 364 schizophrenic patients was investigated and followed up over a 2-year period of outpatient aftercare . Effective therapy and prophylaxis substantially reduced relapses and rehospitalization . On the other hand , the psychosocial situation still showed considerable disadvantages . Of the patients ( 35 years old on average ) , 60% were still unmarried . Almost one-half of the patients still lived alone or with their parents , and one-third lived a very solitary life . At the end of the 2-year aftercare period , one-third was able to earn their own living . Almost one-half retired early from their occupations . Predictors and intervening variables are presented in order to stimulate early rehabilitation approaches . Schizophrenics are particularly placed at a disadvantage by tighter competition in the employment market , even though the course of illness can be improve . Social psychiatry must to be involved in helping to improve social contacts , accommodation and employment in order to prevent major distress ."
],
"offsets": [
[
0,
1181
]
]
}
] |
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] |
[] |
[] |
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DerNervenarzt.80690210.eng.abstr
|
DerNervenarzt.80690210.eng.abstr
|
[
{
"id": "DerNervenarzt.80690210.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Within the framework of a study on vocational rehabilitation of the mentally ill , we examined 83 schizophrenic outpatients enrolled in a work therapy program . The course of illness and rehabilitation was documented over a 3-year period by means of annual follow-up examinations . The sample comprised 44 men and 39 women with an average age of 35 years ( SD +/- 8,5 ) . The majority were chronically ill patients with a history of frequent and long psychiatric hospitalization . After 3 years , 22% of the patients were integrated into the general labor market , 26% had sheltered employment , 23% were still in work therapy , and 29% were unemployed . Besides the patients ' subjective expectations , early introduction of rehabilitative measures and a favourable course of illness were found to be predictors of a successful rehabilitation leading to vocational integration . Outpatient work therapy is a contemporary , effective organizational form of sociotherapy . It may contribute to improved vocational competence and integration , reduced psychiatric hospitalization and stabilized psychopathology ."
],
"offsets": [
[
0,
1110
]
]
}
] |
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}
] |
DerNervenarzt.80690219.eng.abstr
|
DerNervenarzt.80690219.eng.abstr
|
[
{
"id": "DerNervenarzt.80690219.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Subjective quality of life in a group of chronic schizophrenia outpatients was assessed within 1 1/2 years ( n=50) and 4-6 weeks ( n=47) using the Berliner Lebensqualitaetsprofil ( German version of the Lancashire Quality of Life Profile ) . There had been no systematic therapeutic interventions meanwhile . Stability and constancy for the longer interval was similar to results in the general population . The statistics for the shorter interval justify in particular use of the profile's total score and general well-being for the measurement of change . In contrast to cross-sectional data and the longer observation period , no significant common variation between psychopathological symptoms and subjective quality of life could be found for the shorter period ."
],
"offsets": [
[
0,
768
]
]
}
] |
[
{
"id": "DerNervenarzt.80690219.eng.abstr-s1-t1",
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"life"
],
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[
22,
26
]
],
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{
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}
]
},
{
"id": "DerNervenarzt.80690219.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"schizophrenia"
],
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[
49,
62
]
],
"normalized": [
{
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}
]
},
{
"id": "DerNervenarzt.80690219.eng.abstr-s1-t3",
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"text": [
"outpatients"
],
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[
63,
74
]
],
"normalized": [
{
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"db_id": "C0029921"
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},
{
"id": "DerNervenarzt.80690219.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Life"
],
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[
225,
229
]
],
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}
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"id": "DerNervenarzt.80690219.eng.abstr-s1-t5",
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],
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26
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"text": [
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],
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214,
229
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DerNervenarzt.80690228.eng.abstr
|
DerNervenarzt.80690228.eng.abstr
|
[
{
"id": "DerNervenarzt.80690228.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The concept of cycloid psychoses means a certain species as part of the group of schizophrenias . From our clinical point of view , the subtypes of Leonhard and their poles are axial syndromes . They can occur simultaneously or intermingle during one phase . In the present phenomenological study the inner connections of these axial syndromes are shown . Apart from these connections , cycloid psychoses can be differentiated from core schizophrenia by three conditions : ( 1 ) the lack of deformation of affect and affect expression ; ( 2 ) the lack of deformation of thought structure ; and ( 3 ) the lack of certain movement deformations , e.g. , parakinesis . Our concept of phenomenon is explained to criticize the current operational definitions of cycloid psychoses . A different approach is suggested ."
],
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[
0,
811
]
]
}
] |
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{
"id": "DerNervenarzt.80690228.eng.abstr-s2-t1",
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148,
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183,
192
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{
"id": "DerNervenarzt.80690228.eng.abstr-s5-t1",
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"schizophrenia"
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{
"id": "DerNervenarzt.80690228.eng.abstr-s5-t2",
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"movement"
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620,
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{
"id": "DerNervenarzt.80690228.eng.abstr-s5-t3",
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651,
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] |
[] |
[] |
[
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"type": "result_of",
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{
"id": "DerNervenarzt.80690228.eng.abstr-s5-r4-t3.1-t2.1",
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DerNervenarzt.80690238.eng.abstr
|
DerNervenarzt.80690238.eng.abstr
|
[
{
"id": "DerNervenarzt.80690238.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Forty-four first-admission patients with childhood-onset schizophrenia ( age at onset =14 years ) were examined retrospectively for 30 clinical symptoms using the Positive and Negative Syndrome Scale ( PANSS ; 15 ) . A principal component analysis with varimax rotation was applied to the full item set of this scale and revealed five orthogonal independent symptom groups : cognition affect , social withdrawal , anti-social behavior , excitement , and reality distortion . In order to validate these psychopathological dimensions we analyzed the relation between the five factor scores and outcome variables ( Disability Assessment Schedule , DAS-M ; 13 ) several years after onset : Social withdrawal was correlated with poor outcome ; reality distortion was related to good outcome ( P 0.01 ) . A multivariate ANOVA identified group differences in the anti-social behavior factor between acute and insidious onset of illness and between boys and girls ; patients with an acute onset scored significantly higher on the excitement factor than those with an insidious onset ( P 0.05 ) . According to our results more than two dimensions are necessary to describe the psychopathology of childhood-onset schizophrenia , similar to adolescent- and adult-onset schizophrenia ."
],
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0,
1273
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}
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"age"
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DerNervenarzt.80690243.eng.abstr
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DerNervenarzt.80690243.eng.abstr
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"In most factor analytical studies of schizophrenic symptomatology a three-factor solution was found . The aim of this study was to investigate symptomatological dimensions in old age and to clarify whether the dimensions correlate differently with neuropsychological and motor parameters . A total of 131 DSM-III-R schizophrenics ( mean age 68 years ) were assessed using SANS , SAPS , a neuropsychological test battery and motor scales . A factor analysis yielded three dimensions ( negative , desorganized , paranoid ) , two of which ( negative , disorganized ) showed different correlations with neuropsychological and motor phenomena . Thus , three symptomatological dimensions could also be demonstrated in a chronic , old-age schizophrenic sample . The pathophysiological significance of the different correlations with neuropsychological and motor parameters should be clarified in neuroimaging and neuropathological studies ."
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[] |
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DerNervenarzt.80690249.eng.abstr
|
DerNervenarzt.80690249.eng.abstr
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"In this magnetoencephalography study the issue of hemispheric lateralisation in patients with schizophrenia was addressed using acoustically evoked neuromagnetic fields . The characteristics of dipoles in the superior temporal gyrus , the primary auditory cortex , were calculated . In contrast to other studies , alterations did not concern the localisation , but rather the orientation of dipoles . Of pathophysiological interest was that the dipoles abnormalities were found left-hemispherically in male ( p=0.02) and right-hemispherically in female patients with schizophrenia ( p=0.01) when compared to controls . The findings suggest gender-specific alterations of hemispheric lateralisation in schizophrenia ."
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[] |
[] |
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] |
DerNervenarzt.80690264.eng.abstr
|
DerNervenarzt.80690264.eng.abstr
|
[
{
"id": "DerNervenarzt.80690264.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Wilson's disease is a rare , autosomal recessive disorder of copper metabolism due to low serum ceruloplasm , resulting in increased copper deposition , especially in the liver and basal ganglia in the brain . The pseudosclerotic type of Wilson's disease , also known as the Westphal-Struempell form , is distinguished by positional tremor , ataxia and dysarthria as the main symptoms . We use the example of a 23-year-old patient whose neurological symptoms were preceded by a long history of a schizophrenic-like disorder . Clinical symptoms are presented . MRI , SPECT and PET images are illustrated . Therapy and outcome are discussed ."
],
"offsets": [
[
0,
640
]
]
}
] |
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] |
[] |
[] |
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DerNervenarzt.80690287.eng.abstr
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DerNervenarzt.80690287.eng.abstr
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"id": "DerNervenarzt.80690287.eng.abstr-passage-0",
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"The rapid development of modern endovascular , microsurgical , and radiation therapies has considerably expanded the treatment options for encephalic arteriovenous malformations ( AVMs ) . Surgery has the longest history . Single or staged intravascular procedures ( embolizations ) using fast-acting glues , sclerotic agents , and thrombogenic coils serve to reduce the size of AVM to that suitable for extirpation and may reduce the risk of surgery . Radiation ( \" gamma-knife \" ) therapy , most frequently used in small , non-operable AVMs , is also viewed by some authors as an alternative or even superior tool in small , operable malformations . Partial embolization to reduce the mass-effect of space-occupying AVMs , to reverse diaschisis , and to treat AVM-related seizure disorders is being discussed and practiced . Given the in part competing or even controversial options , the selection of optimal treatment for AVM patients is becoming increasingly difficult . Current management is impeded by the paucity of information on the exact risks of invasive therapies and by insufficient criteria for identifying patients at risk of spontaneous bleeding during the natural course , including the seriousness of such hemorrhage ."
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[] |
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DerNervenarzt.80690296.eng.abstr
|
DerNervenarzt.80690296.eng.abstr
|
[
{
"id": "DerNervenarzt.80690296.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the past little attention was paid to the thoracoabdominal manifestation of Lyme radiculoneuritis , because paralysis of the abdominal wall muscles was considered to be a very uncommon clinical manifestation of Lyme neuroborreliosis . In a group of 90 patients suffering from early stage . Lyme neuroborreliosis we found abdominal wall weakness in 11 cases . In the majority of patients thoracoabdominal radiculoneuritis was located in he lower thoracic segments ( Th 7-12 ) and involved more than 3 segments ( 62% ) mostly bilaterally ( 69% ) . Abdominal wall paralysis was mostly bilateral ( 91% ) and involved always the lower half of the abdominal wall . It was very severe in 18% . Electromyographic studies were done in the paraspinal and abdominal wall muscles showing fibrillation potentials and positive sharp waves in 86% and 50% , respectively . Diagnosis of thoracoabdominal radiculoneuritis in Lyme neuroborreliosis may be difficult and diagnostic errors may occur . Therefore we recommend to look carefully for paralysis of the abdominal wall , which can easily be overlooked on routine neurological examination . In patients from an area with a high incidence of Lyme disease it is recommended to exclude neuroborreliosis even in patients with known diabetes mellitus in order to avoid the misdiagnosis of diabetic thoracoabdominal radiculopathy . This has occured in 2 of our patients ."
],
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] |
DerNervenarzt.80690300.eng.abstr
|
DerNervenarzt.80690300.eng.abstr
|
[
{
"id": "DerNervenarzt.80690300.eng.abstr-passage-0",
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"This 1-year follow-up study included 17 patients with spinal cord injuries who participated in a functional electrical stimulation ( FES ) program for restoration of the ability to stand and walk . Four tetraplegic patients reached a mean FES-assisted standing duration of 6.8 min after 6 weeks . After 1 year three patients had stopped FES-assisted standing due to orthostatic problems and only used the system for cyclic stimulation of quadriceps muscles while lying down . Ten paraplegic patients had a mean standing duration of 22.6 min . The gait velocity ( gait distance ) of seven patients ranged from 2.9 to 24.2 m/min ( from 4 to 335 m ) in seven patients . Due to flexor spasm in two and unrealistic expectations in seven cases , four patients stopped the program and five only practiced FES-assisted standing . One patient continued FES walking after 1 year . Three patients with an incomplete cervical lesion who had been able to walk a short distance before treatment achieved constant improvement their gait ability . Their gait velocity/walking distance without FES improved for a mean of +33 . 3%/+163 . 8% . after 6 weeks . Assuming that FES is used according to the level of impairment , the results favor broader application of the method in the rehabilitation of patients with spinal cord injuries ."
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},
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},
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},
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},
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},
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r5-t1.2-t2.2",
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},
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r6-t1.1-t4.2",
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},
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r7-t2.2-t1.2",
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},
{
"id": "DerNervenarzt.80690300.eng.abstr-s13-r8-t1.1-t5.1",
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},
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r10-t2.2-t1.1",
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},
{
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r14-t4.1-t5.1",
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{
"id": "DerNervenarzt.80690300.eng.abstr-s13-r15-t4.1-t5.3",
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"id": "DerNervenarzt.80690300.eng.abstr-s13-r16-t4.1-t1.2",
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}
] |
DerNervenarzt.80690306.eng.abstr
|
DerNervenarzt.80690306.eng.abstr
|
[
{
"id": "DerNervenarzt.80690306.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Today lumbar spinal stenosis can stand on its own as a clinical entity that can be radiologically and clinically divided into central and lateral stenosis . Foraminal stenosis is a special form of the latter . During the period 1990-1991 we operated on 148 patients for spinal stenosis . Using a standardized questionnaire , 109 patients were evaluated on their pain and gait status 3 years after the operation . Patients with previously known spondylolisthesis or degenerative instability were excluded from the study . Forty-four out of 109 patients were free of pain , while significant reduction of pain was noted in 35/109 patients . In 19 patients , the pain remained the same or worsened postoperatively . Seventy-four out of the 109 patients had no gait disturbances , whereas only 14/109 worsened postoperatively . Six patients could walk with support and seven patients were unable to walk because of other disturbances . Because of unclear responses , the status of the remaining patients could not be completely evaluated in either group ."
],
"offsets": [
[
0,
1051
]
]
}
] |
[
{
"id": "DerNervenarzt.80690306.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"stenosis"
],
"offsets": [
[
20,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009814"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"stenosis"
],
"offsets": [
[
146,
154
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009814"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"spinal stenosis"
],
"offsets": [
[
13,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037944"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"stenosis"
],
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[
167,
175
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009814"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"form"
],
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[
189,
193
]
],
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{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"period"
],
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[
221,
227
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"patients"
],
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[
257,
265
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],
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"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"stenosis"
],
"offsets": [
[
277,
285
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009814"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"spinal stenosis"
],
"offsets": [
[
270,
285
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037944"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"questionnaire"
],
"offsets": [
[
309,
322
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034394"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
329,
337
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"pain"
],
"offsets": [
[
362,
366
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030193"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"gait"
],
"offsets": [
[
371,
375
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016928"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"operation"
],
"offsets": [
[
401,
410
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543467"
},
{
"db_name": "UMLS",
"db_id": "C0038895"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Patients"
],
"offsets": [
[
413,
421
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"spondylolisthesis"
],
"offsets": [
[
444,
461
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038016"
}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
543,
551
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"pain"
],
"offsets": [
[
565,
569
]
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"pain"
],
"offsets": [
[
603,
607
]
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
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628,
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]
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}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"patients"
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645,
653
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]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"pain"
],
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[
660,
664
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},
{
"id": "DerNervenarzt.80690306.eng.abstr-s8-t1",
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"patients"
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741,
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}
]
},
{
"id": "DerNervenarzt.80690306.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"gait"
],
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757,
761
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{
"id": "DerNervenarzt.80690306.eng.abstr-s10-t1",
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"text": [
"patients"
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991,
999
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
}
] |
[] |
[] |
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"id": "DerNervenarzt.80690306.eng.abstr-s1-r2-t3.1-t2.1",
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"id": "DerNervenarzt.80690306.eng.abstr-s1-r7-t1.1-t3.1",
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},
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"id": "DerNervenarzt.80690306.eng.abstr-s5-r1-t2.1-t1.1",
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] |
DerNervenarzt.80690312.eng.abstr
|
DerNervenarzt.80690312.eng.abstr
|
[
{
"id": "DerNervenarzt.80690312.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the final stage of amyotrophic lateral sclerosis ( ALS ) the majority of patients develop chronic respiratory failure due to respiratory muscle weakness . The interaction between the patient with ALS and the physician should be characterized by continuous communication , especially with respect to the prospect of ventilatory failure and for support . The patient and his family must be informed thoroughly about the natural history and the prognosis of ALS , depending on the individual disease process . Already in the early stage of the disease coping strategies should be discussed so that imminent respiratory emergencies can be handled . If ALS patients are not informed about the acute respiratory insufficiency they run the risk of having to be intubated and mechanically ventilated over a long term ."
],
"offsets": [
[
0,
813
]
]
}
] |
[
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t1",
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"text": [
"stage"
],
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[
13,
18
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0027646"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"sclerosis"
],
"offsets": [
[
42,
51
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036429"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
76,
84
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"muscle"
],
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[
140,
146
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026845"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"weakness"
],
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147,
155
]
],
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{
"db_name": "UMLS",
"db_id": "C0086525"
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}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"lateral sclerosis"
],
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[
34,
51
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0154682"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"respiratory failure"
],
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101,
120
]
],
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"db_name": "UMLS",
"db_id": "C0035229"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"respiratory muscle"
],
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128,
146
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035231"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"muscle weakness"
],
"offsets": [
[
140,
155
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0151786"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"amyotrophic lateral sclerosis"
],
"offsets": [
[
22,
51
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002736"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"interaction"
],
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[
162,
173
]
],
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{
"db_name": "UMLS",
"db_id": "C0037420"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
186,
193
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"ALS"
],
"offsets": [
[
199,
202
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002736"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"physician"
],
"offsets": [
[
211,
220
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031831"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"communication"
],
"offsets": [
[
259,
272
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009452"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
360,
367
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"family"
],
"offsets": [
[
376,
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]
],
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]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"history"
],
"offsets": [
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]
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]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"prognosis"
],
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445,
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"db_id": "C0033325"
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]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"ALS"
],
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{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"disease"
],
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492,
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"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerNervenarzt.80690312.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"natural history"
],
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[
421,
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]
],
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"db_name": "UMLS",
"db_id": "C0175860"
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{
"id": "DerNervenarzt.80690312.eng.abstr-s4-t1",
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"text": [
"stage"
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{
"id": "DerNervenarzt.80690312.eng.abstr-s4-t2",
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{
"id": "DerNervenarzt.80690312.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"emergencies"
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{
"id": "DerNervenarzt.80690312.eng.abstr-s5-t3",
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"text": [
"respiratory insufficiency"
],
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"id": "DerNervenarzt.80690312.eng.abstr-s5-t4",
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"risk of"
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"db_name": "UMLS",
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}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r1-t2.1-t6.1",
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{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r2-t2.1-t5.1",
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{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r3-t4.1-t9.1",
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},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r4-t3.1-t1.1",
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},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r5-t1.1-t3.1",
"type": "affects",
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{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r6-t6.1-t4.1",
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},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r7-t9.1-t10.1",
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},
{
"id": "DerNervenarzt.80690312.eng.abstr-s1-r8-t8.1-t2.1",
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"id": "DerNervenarzt.80690312.eng.abstr-s1-r9-t6.1-t3.1",
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"id": "DerNervenarzt.80690312.eng.abstr-s1-r11-t2.1-t10.1",
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DerNervenarzt.80690320.eng.abstr
|
DerNervenarzt.80690320.eng.abstr
|
[
{
"id": "DerNervenarzt.80690320.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The aim of the open prospective study was to investigate the efficacy , safety and tolerability of subcutaneous sumatriptan in the acute treatment of cluster headache . Self-treatment with 6 mg sumatriptan subcutaneously was monitored over a period up to 1 year . Headache parameters were documented by the patients with a headache diary . A total of 2031 attacks in 52 patients were investigated . Treatment with sumatriptan was effective in 88% of the attacks and 57% of the patients were pain-free within 15 min after injection ; 42% of the patients became painfree within 15 min after at least 90% of their attacks . During long-time treatment the efficacy remained unchanged . Of the patients 10% withdrew from the study due to lack of efficacy or adverse events . In total , 62% of the patients reported adverse events , which were serious in 3.8% of the cases . Subcutaneous self-treatment of cluster headache is both highly effective and well tolerated ."
],
"offsets": [
[
0,
962
]
]
}
] |
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DerNervenarzt.80690330.eng.abstr
|
DerNervenarzt.80690330.eng.abstr
|
[
{
"id": "DerNervenarzt.80690330.eng.abstr-passage-0",
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"text": [
"In the acute phase of cerebral ischemia , 55% of the patients showed signs of mild depression after a period of 5-9 days . The development and intensity of depressive symptoms correlated strongly with the grade of functional impairment . A statistically less significant relationship was established between the depressive symptoms and low social status , higher age , lower predisease intelligence and accompanying symptomes of anxiety . Independent of antidepressive therapy , after 4 weeks an improvement in the initially registered functional and intellectual impairment as well as the depressive symptoms ( prevalence rate 23.3% ) was recorded . None of these parameters correlated with each other in any way . In conclusion , we interpreted these depressive symptoms as the result of reactive coping strategies during the acute phase of cerebral ischemia . In contrast to this , the aspect of gender showed no significant relationship to the resulting depressive symptoms . Furthermore , lesion location , lesion volume , and cortical atrophy and cognitive impairment proved to have no influence on depressive symptoms . This suggests that primary organic factors are not the cause of depression in connection with the acute stroke period ."
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0,
1246
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[] |
[] |
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DerNervenarzt.80690335.eng.abstr
|
DerNervenarzt.80690335.eng.abstr
|
[
{
"id": "DerNervenarzt.80690335.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The differential diagnosis of the rupture of flexor pollicis longus tendon and profundus tendon to index finger to the interosseus anterior nerve syndrome can be difficult and can lead to misinterpretation of the clinical impression . Two cases are reported to demonstrate this problem . In the first case a spontaneous rupture of flexor pollicis longus was found , when first an interosseus anterior nerve syndrome was suspected . In a second case surgical exploration of flexor pollicis longus tendon and profundus tendon to index finger was done on the assumption of a rupture , that revealed intact tendons . In a second operation neurolysis of the interosseus anterior nerve was carried out with full recovery of flexion of the thumb and index finger ."
],
"offsets": [
[
0,
757
]
]
}
] |
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] |
[] |
[] |
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DerNervenarzt.80690352.eng.abstr
|
DerNervenarzt.80690352.eng.abstr
|
[
{
"id": "DerNervenarzt.80690352.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Septo-optic dysplasia ( or de Morsier syndrome ) is a congenital disorder characterised by anomalies in cerebral midline structures , optic nerve hypoplasia , and hormonal deficiencies . Diagnosis should be made early , due to the possibility of treating the hormonal disturbances . We describe here a case with decreased visual acuity , one-sided hemianopia , nystagmus und agenesis of the septum pellucidum and discuss the heterogeneous appearance of this syndrome . There are two theories regarding its pathogenesis . The first postulates simultaneous damage to both cerebral structures and optic nerve development around the 6th week of gestation , while the other favours secondary degeneration of optic nerve fibres due to a cerebral lesion ."
],
"offsets": [
[
0,
748
]
]
}
] |
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11
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] |
DerNervenarzt.80690357.eng.abstr
|
DerNervenarzt.80690357.eng.abstr
|
[
{
"id": "DerNervenarzt.80690357.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tumors of the tibial nerve are not sufficiently taken into account in the diagnosis of tarsal tunnel syndromes ( TTS ) . They may present with atrophy of the plantar flectors and with disturbances of sensory functions , but far more commonly with pain . Diagnosis is often only achieved after 1-2 years . Taking tumors into account when examining patients presenting with TTS may lead to a more rapid diagnosis and to improvement in patients ' prognoses . We present the case of a 37-year-old female in whom a primitive neuroectodermal tumor ( PNET ) was found to be the cause of long-standing pain in the right foot ."
],
"offsets": [
[
0,
618
]
]
}
] |
[
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Tumors"
],
"offsets": [
[
0,
6
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nerve"
],
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[
21,
26
]
],
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{
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"db_id": "C0027769"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t3",
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"text": [
"diagnosis"
],
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[
74,
83
]
],
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{
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"db_id": "C0011900"
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{
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}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"syndromes"
],
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[
101,
110
]
],
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{
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"db_id": "C0039082"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"tibial nerve"
],
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[
14,
26
]
],
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{
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"db_id": "C0040186"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"tarsal tunnel syndromes"
],
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[
87,
110
]
],
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"db_id": "C0039319"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"atrophy"
],
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[
143,
150
]
],
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{
"db_name": "UMLS",
"db_id": "C0004255"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"flectors"
],
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[
166,
174
]
],
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{
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"db_id": "C0526575"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"functions"
],
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[
208,
217
]
],
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{
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"db_id": "C0031843"
}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"pain"
],
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[
247,
251
]
],
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{
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"db_id": "C0030193"
}
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},
{
"id": "DerNervenarzt.80690357.eng.abstr-s3-t1",
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"text": [
"Diagnosis"
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}
]
},
{
"id": "DerNervenarzt.80690357.eng.abstr-s4-t1",
"type": "umlsterm",
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"tumors"
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312,
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"id": "DerNervenarzt.80690357.eng.abstr-s4-t2",
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{
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{
"id": "DerNervenarzt.80690357.eng.abstr-s5-t6",
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"right"
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"id": "DerNervenarzt.80690357.eng.abstr-s5-t8",
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"id": "DerNervenarzt.80690357.eng.abstr-s5-t9",
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}
] |
[] |
[] |
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DerNervenarzt.80690361.eng.abstr
|
DerNervenarzt.80690361.eng.abstr
|
[
{
"id": "DerNervenarzt.80690361.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease ."
],
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DerNervenarzt.80690369.eng.abstr
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DerNervenarzt.80690369.eng.abstr
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[
{
"id": "DerNervenarzt.80690369.eng.abstr-passage-0",
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"text": [
"The relation of age associated changes of cognitive functions to those of dementia diseases is not well investigated for very old age . Because aging as well as dementia diseases are associated with cognitive deficits , this leads to differential diagnostic problems in very old age . Relevant with respect to this differentiation are on the one hand the concepts of cognitive ageing , the dementia syndrome and dementia diseases , and on the other hand empirical findings with respect to 1. the neuropsychological crossectional pattern , 2. the premorbid intelligence or adult intelligence level , 3. the speed of decline . ad 1. The speed of cognitive processes shows a considerable reduction in normal aging . However , the reduction of learning and orientation as well as pronounced word-finding problems seem to be characteristic of the development of a dementia syndrome . ad 2. The importance of the level of adult intelligence is demonstrated by the possibility that a very old person with low adult intelligence level is diagnosed as demented without suffering from one of the dementia diseases . In the opposite case of a slowly progressive dementia disease in a person with a superior level of adult intelligence a diagnosis of dementia according the standard criteria can be given only in an advanced stage of the disease . ad 3. The importance of the speed of decline of cognitive performance for the diagnosis of dementia is discussed ( e.g. 1 point of the MMSE vs > 3 MMSE points per year ) . An optimization of the time course criterion ( change-sensitive tests and an empirically determined cut-off ) could improve the early dementia diagnosis , which relies up to now mostly on crossectional features . The more precise assessment of the deterioration speed would be an opportunity to investigate the factors or processes which determine the deterioration speed , knowledge of which in turn would be a starting point for development of therapy ."
],
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0,
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] |
DerNervenarzt.80690379.eng.abstr
|
DerNervenarzt.80690379.eng.abstr
|
[
{
"id": "DerNervenarzt.80690379.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 40 patients with Alzheimer's disease ( AD ) , in 5 patients with non-AD dementia and in 36 cognitively normal controls the concentration of protein tau was determined in the cerebrospinal fluid ( CSF ) . Of the AD patients , 19 were very mildly demented ( MMSE score from 25 to 28 ) . Even in these patients , CSF tau was significantly more elevated than in controls . In the non-AD patients protein tau was less increased . Among the AD patients there was no association between CSF tau and severity of cognitive impairment or deficit in cerebral blood flow , determined by SPECT . Our findings suggest that CSF tau may be elevated even at the predementia stage of AD and be useful as a biological marker for the early recognition of the disease ."
],
"offsets": [
[
0,
751
]
]
}
] |
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{
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{
"id": "DerNervenarzt.80690379.eng.abstr-s1-t7",
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"protein"
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"id": "DerNervenarzt.80690379.eng.abstr-s1-t9",
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"cerebrospinal fluid"
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177,
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{
"id": "DerNervenarzt.80690379.eng.abstr-s2-t1",
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{
"id": "DerNervenarzt.80690379.eng.abstr-s3-t2",
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"CSF"
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{
"id": "DerNervenarzt.80690379.eng.abstr-s4-t2",
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"protein"
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"id": "DerNervenarzt.80690379.eng.abstr-s5-t1",
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"id": "DerNervenarzt.80690379.eng.abstr-s5-t2",
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"id": "DerNervenarzt.80690379.eng.abstr-s5-t3",
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"id": "DerNervenarzt.80690379.eng.abstr-s6-t1",
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] |
[] |
[] |
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{
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{
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DerNervenarzt.80690386.eng.abstr
|
DerNervenarzt.80690386.eng.abstr
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"id": "DerNervenarzt.80690386.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The philosophical debate on explanation and understanding also led to basic methodological reflections in psychiatry . Subsuming one fact under a general law is the characteristic feature of scientific explanations . In this way , deductive conclusions can be achieved with a high degree of objectivity . Hermeneutical understanding makes way for interpretations in front of a given theoretical matrix . On the other hand , sympathetic understanding is a matter of conceiving single-part items as a consequence of other singular aspects ( e.g. , tracing back an action to an intention ) . If one understands the growth of knowledge as a rational and critical process , it seems no more justified to insist on exclusive methodologically based positions ."
],
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753
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]
}
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[] |
[] |
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DerNervenarzt.80690390.eng.abstr
|
DerNervenarzt.80690390.eng.abstr
|
[
{
"id": "DerNervenarzt.80690390.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Taking into account the different concepts of delusion and analysing rational and intuitive cognition , the present phenomenological-conceptual study aims at defining the essential nature of delusion . Intuitive cognition as a result of holistic processing is founded in the development of polysensoric-kinaesthetic basic pictures ( eidetic matrices ) , which are recognized preverbally and prereflexively by subliminal perception of corresponding eidetic structures . A positive match between a matrix and a given phenomenon produces an eidetic feeling . This eidetic feeling encompasses three aspects . The first is a preverbal knowledge of something as something definite . As a direct self-reference , the second is the feeling of an object-inherent significance of the given phenomenon for the subject itself . Thirdly , a power vector is perceived to derive from the object . The application of this concept allows us to consider delusion as a disturbance in the system of holistic information processing . This disturbance is characterized by a disinhibition and actualization of eidetic matrices in different ways . The resulting eidetic feeling we call delusion ; its expression in thoughts and words we call a delusional idea . All features of an eidetic feeling can be demonstrated in delusion . Owing to their special intensity and suspended reason , they mostly appear to be unique . The analysis of the eidetic structures of delusion allows a deeper understanding of delusion and facilitates both its diagnosis and its differentiation . Heterogeneous terms , such as delusional mood , idea of meaning , idea of reference , delusional notion and delusional perception emerge in an understandable context ."
],
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DerNervenarzt.80690401.eng.abstr
|
DerNervenarzt.80690401.eng.abstr
|
[
{
"id": "DerNervenarzt.80690401.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During a 18-year-period 93 patients ( f=76, m=17) with a factitious disorder were identified in the psychiatric consultation service of a university hospital ( incidence : 0.62% ) . 50% of women were working in medical professions whereas only 6% of men . Chronic courses of illness were prevailing , but at least one quarter of female patients showed an intermittent type . There was a classical Munchhausen syndrome in 11% of patients . Depressive and anxiety disorders ( 10% , 4% ) were to be respected as psychiatric comorbidity . Ca 25% of the patients suffered from a somatic illness in addition to the factitious disorder , and one third of the women had symptoms of psychosomatic , especially of eating disorders . Previous somatoform disorders , deliberate self harm and attempts of suicide were to be noted in the psychiatric history of many patients . There were frequent traumatizing events ( foster home , disturbing family disharmony , physical and sexual abuse , early losses , serious illnesses ) in the early biography . Various psychosocial stressors could be identified in the actual eliciting situation . The results are discussed in respect of epidemiology , development and clinical phenomenology of factitious disorders , psychodynamics and psychopathology of deception and self harm , and therapeutic options in the psychiatric consultation service ."
],
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0,
1374
]
]
}
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DerNervenarzt.80690410.eng.abstr
|
DerNervenarzt.80690410.eng.abstr
|
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"id": "DerNervenarzt.80690410.eng.abstr-passage-0",
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"According to DSM-IV affective instability in borderline personality disorder is due to marked reactions to environmental events . The aim of this study was to investigate affective responsiveness of abnormal personalities with self-harming impulsive behaviors by means of an affect-stimulation design . The first experiment was based on the presentation of a short story that allowed affective responses to various stimuli to be assessed in regard to quality , intensity , and alterations over time . The second one presented a typical frustration design , which provoked specific feelings of anger and disappointment . Impulsive personalities showed an affective hyperreactivity that was characterized by a decreased threshold for affective responses , as well as by intensive , rapidly changing affects . Furthermore , affect experiences turned out to be qualitatively diffuse and undifferentiated . Results support that affective instability of patients with borderline personality disorder should be differentiated from the autonomous deviations of mood typical of affective disorders . Their affective hyperreactivity is a crucial part of impulsive personality functioning ."
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1179
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] |
DerNervenarzt.80690437.eng.abstr
|
DerNervenarzt.80690437.eng.abstr
|
[
{
"id": "DerNervenarzt.80690437.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The young Heinrich Heine showed signs of pseudologia phantastica . While studying the diaries of his greatuncle , he identified with the latter . The underlying factors of this psychopathological development are discussed in this paper ."
],
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[
0,
237
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]
}
] |
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[] |
[] |
[] |
DerNervenarzt.80690440.eng.abstr
|
DerNervenarzt.80690440.eng.abstr
|
[
{
"id": "DerNervenarzt.80690440.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recently the concept of dissociative identity disorder ( formerly known as multiple personality disorder ) has attracted increasing public and scientific interest . However , it is rarely diagnosed in the clinical setting . The reported case of a 47-year-old woman with a history of child abuse demonstrates the problems of differential diagnosis . A number of psychopathologic symptoms pointed to a multiple personality disorder , but in the follow-up psychotic symptoms such as delusions , possible hallucinations and bizarre behavior clearly emerged . The differential diagnosis of dissociative identity disorder includes paranoid schizophrenia , as in the case described , borderline personality disorder , hysteria , simulation and the false memory syndrome . Finally , social and cultural factors have to be considered ."
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DerNervenarzt.80690446.eng.abstr
|
DerNervenarzt.80690446.eng.abstr
|
[
{
"id": "DerNervenarzt.80690446.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Dysmorphophobia shall be described as an example for a communicative disorder and be deliminated from other syndromes under which it has been subsumed so far . On the background of available literature , the \" fear of deformity \" is to be elaborated as feeling ashamed of the contemptuous look of another person , whose look has turned into the own view . This results in a discrepancy with the ego and the own self conveyed by others , finally leading to depersonalisation . This basic interpersonal appearance shall be further illustrated by two individual examples ."
],
"offsets": [
[
0,
569
]
]
}
] |
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[] |
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DerNervenarzt.80690451.eng.abstr
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DerNervenarzt.80690451.eng.abstr
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[] |
[] |
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DerNervenarzt.80690459.eng.abstr
|
DerNervenarzt.80690459.eng.abstr
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[
{
"id": "DerNervenarzt.80690459.eng.abstr-passage-0",
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"Apoptosis and programmed cell death have attracted major scientific interest during the last few years . Apoptosis can be differentiated from necrosis by means of morphological , biochemical , molecular and pharmacological parameters . Several molecular pathways leading to apoptosis have been elucidated over the last few years . Apoptosis is not only important for physiological cell turnover , but also plays a role in many pathological processes . Recently , a number of laboratories have found evidence of apoptotic cell death in cerebral ischemia in animal models . Quantitatively , apoptosis seems to be important in the border zone of the infarction , the so-called penumbra . Since parts of the apoptotic cascade can be inhibited , pharmacological treatment seems feasible . The so-called caspase inhibitors are promising therapeutic agents for the treatment of acute stroke and may be administered with other neuroprotective medications in humans in the near future ."
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DerNervenarzt.80690465.eng.abstr
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DerNervenarzt.80690465.eng.abstr
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"At least three questions has to be answered by imaging methods , when new therapies in acute ischemic stroke should be used : 1. Is there a cerebral ischemia ? 2. What is the size of the irreversibel damaged tissue and what is the size of the safeable tissue ? Is there still a vessel occlusion ?"
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[] |
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DerNervenarzt.80690472.eng.abstr
|
DerNervenarzt.80690472.eng.abstr
|
[
{
"id": "DerNervenarzt.80690472.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Exercise tests are widely used as simple , noninvasive screening methods in the differential diagnosis of metabolic myopathies . Exercise protocols have not been standardized with regard to duration of the test , workload , or monitored metabolic parameters . Potentially interfering parameters such as gender or maximal isometric force of the individuals have not been investigated . Here we describe a standardized bicycle ergometry protocol with a stepwise increasing workload between 30 and 100 watts . The venous lactate/pyruvate ( L/P ) ratio proved to be the one clinically most useful parameter in the functional diagnosis of mitochondrial myopathies with pathological exercise values in all nine examined patients . Additionally , the effects of coenzyme Q therapy in these patients were most clearly mirrored by changes in the L/P ratio . Nonspecifically elevated venous lactate concentrations above 5 mmol/l are rarely found in healthy female volunteers with low maximal isometric force of the M. quadriceps femoris . Other parameters such as serum free fatty acids , ketone bodies , intermediate products of the Krebs cycle or spirometric investigations add only little additional information . The exercise test described may be useful as an additional investigation in the differential diagnosis of metabolic myopathies ."
],
"offsets": [
[
0,
1335
]
]
}
] |
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{
"id": "DerNervenarzt.80690472.eng.abstr-s1-t1",
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0,
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{
"id": "DerNervenarzt.80690472.eng.abstr-s1-t2",
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"tests"
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14
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{
"id": "DerNervenarzt.80690472.eng.abstr-s1-t3",
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"text": [
"screening"
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55,
64
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],
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"db_id": "C0220908"
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"diagnosis"
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{
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116,
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{
"id": "DerNervenarzt.80690472.eng.abstr-s1-t7",
"type": "umlsterm",
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0,
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"id": "DerNervenarzt.80690472.eng.abstr-s1-t8",
"type": "umlsterm",
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80,
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DerNervenarzt.80690485.eng.abstr
|
DerNervenarzt.80690485.eng.abstr
|
[
{
"id": "DerNervenarzt.80690485.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Electroencephalography ( EEG ) is a well-tolerated non-invasive method and is therefore well suited for repetitive examinations . We performed serial EEG's on 117 HIV patients without any clinical signs of secondary neuromanifestation in order to document electroencephalographic changes in the course of HIV infection . Clinical signs of HIV-associated encephalopathy presented 18 patients at the first examination and 23 at reexamination . EEGs were analyzed visually ; there was a mean interval of 20.3 +/- 13.7 months between the first and the second examination . Significant slowing of background activity occurred in the course of the disease ; the rhythm decreased from 10.7 +/- 2.3 Hz to 10.0 +/- 2.4 Hz ( P 0.05 ) with an increase in amplitudes from 60.9 +/- 24.6 µV to 69.5 +/- 33.7 µV ( P 0.05 ) . The percentage of spontaneous dysrhythmias also increased from 30.7% to 41.8% ( P 0.05 ) ; pathological findings provoked by hyperventilation increased from 13.6% to 18.2% . Foci occurred rarely and did not increase in frequency with time . CD4 cell counts decreased from 294.2 +/- 209.5/µl to 188.7 +/- 208.3/µl ( P 0.01 ) . The results of this study indicate progressive CNS dysfunction with worsening of the immunostatus ."
],
"offsets": [
[
0,
1235
]
]
}
] |
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[] |
[] |
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] |
DerNervenarzt.80690495.eng.abstr
|
DerNervenarzt.80690495.eng.abstr
|
[
{
"id": "DerNervenarzt.80690495.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Diagnosis of parasomnias in the sleep laboratory is difficult since the nocturnal behavior reported by the patients often does not show up in the laboratory . To test the efficacy of sleep deprivation as a tool to provoke somnambulism we investigated ten patients ( three women and seven men , mean age 27 +/- 3.4 ) with somnambulism . Their standard polysomnographies and videomonitored nocturnal behavior was compared to that of sex- and age-matched controls and to polysomnography and behavior after sleep deprivation . Patients with parasomnias and controls did not show significant differences in sleep parameters with the exception of longer arousal duration in controls , which was nonsignificant . In magnetic resonance tomography , patients with parasomnias did not reveal abnormality of the brain that might explain release of nocturnal behavior . Sleep deprivation led to significantly reduced number of arousals , reduced arousal index , significantly prolonged arousal duration and more stage shifts from all sleep stages ( nonsignificant ) . Complex behavior during sleep increased under sleep deprivation , whereas sleepwalking did not increase . The majority of complex behavior during sleep is triggered by stage shifts and not by arousal in the sense of the arousal definition of the American Sleep Disorder Society . Complex behavior in sleep is stereotypical and nonviolent . Its complexity seems to depend on the duration and intensity of arousals . Sleep deprivation can be recommended as an efficacious method of increasing complex behavior in sleep , which is a preliminary stage of sleepwalking . Concerning the underlying pathology it seems to be important to register the quality and duration of stimuli that trigger arousals instead of focusing the number of arousals alone ."
],
"offsets": [
[
0,
1803
]
]
}
] |
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0,
9
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{
"id": "DerNervenarzt.80690495.eng.abstr-s1-t2",
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"text": [
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13,
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DerNervenarzt.80690507.eng.abstr
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DerNervenarzt.80690507.eng.abstr
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[
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"type": "abstract",
"text": [
"Some 114 patients with idiopathic Parkinson's disease ( not demented , no tremor dominance ; mean age : 67.0 years ; mean duration of illness : 6.1 years ) were subjected to the manual dexterity test \" MLS \" ( \" Motorische Leistungs Serie \" ) . A retest was carried out 24 h later with no change in medication . Thus , adequate conditions were present for testing the stability of dimensions of manual dexterity . In addition , data from the initial measurement were normalized ( T norms ) . The correlations of the values from both measurements ( retest reliability ) underscore the constancy of manual dexterity functions . Subtests show adequate stability of measurement so that they can be used for diagnosing dexterity disturbances in individual patients . Charts listing normal values and critical differences allow intra- and interindividual comparisons . It is thus possible to make statistically sound predictions for individual patients concerning the effectiveness of therapy or progression of illness with respect to manual dexterity . In addition , differences on the left and right sides can be tested for statistic significance ."
],
"offsets": [
[
0,
1144
]
]
}
] |
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{
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"patients"
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9,
17
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}
]
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{
"id": "DerNervenarzt.80690507.eng.abstr-s1-t2",
"type": "umlsterm",
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"disease"
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46,
53
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"db_name": "UMLS",
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{
"id": "DerNervenarzt.80690507.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"tremor"
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74,
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"age"
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98,
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}
]
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"manual"
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178,
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"test"
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195,
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{
"id": "DerNervenarzt.80690507.eng.abstr-s2-t1",
"type": "umlsterm",
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"medication"
],
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299,
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"id": "DerNervenarzt.80690507.eng.abstr-s3-t1",
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"manual"
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395,
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"id": "DerNervenarzt.80690507.eng.abstr-s4-t1",
"type": "umlsterm",
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"measurement"
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450,
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"id": "DerNervenarzt.80690507.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"values"
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516,
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{
"id": "DerNervenarzt.80690507.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"measurements"
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533,
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"id": "DerNervenarzt.80690507.eng.abstr-s5-t3",
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"manual"
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{
"id": "DerNervenarzt.80690507.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"functions"
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{
"id": "DerNervenarzt.80690507.eng.abstr-s6-t1",
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"measurement"
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662,
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"id": "DerNervenarzt.80690507.eng.abstr-s6-t2",
"type": "umlsterm",
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"patients"
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"id": "DerNervenarzt.80690507.eng.abstr-s7-t1",
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"values"
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"id": "DerNervenarzt.80690507.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"normal values"
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777,
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{
"id": "DerNervenarzt.80690507.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"sound"
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905,
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{
"id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
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"patients"
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{
"id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"therapy"
],
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979,
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}
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{
"id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"manual"
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1029,
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"right"
],
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[
1090,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035621"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r1-t6.1-t2.1",
"type": "affects",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s1-t6",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r2-t6.1-t4.2",
"type": "affects",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s1-t4",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r3-t4.2-t4.1",
"type": "produces",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r4-t6.1-t3.1",
"type": "treats",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r5-t2.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r6-t2.1-t3.1",
"type": "associated_with",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r7-t4.1-t5.1",
"type": "uses",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r8-t1.1-t5.1",
"type": "uses",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r9-t6.1-t2.1",
"type": "diagnoses",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r10-t1.1-t4.1",
"type": "interacts_with",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r11-t2.1-t4.1",
"type": "occurs_in",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r12-t4.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r13-t3.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r14-t2.1-t4.2",
"type": "result_of",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s1-t4",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r15-t3.1-t4.2",
"type": "evaluation_of",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r16-t5.1-t2.1",
"type": "causes",
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},
{
"id": "DerNervenarzt.80690507.eng.abstr-s1-r17-t4.2-t2.1",
"type": "result_of",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r1-t2.1-t1.1",
"type": "measures",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r2-t1.1-t4.1",
"type": "measures",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r3-t2.1-t4.1",
"type": "measures",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r4-t1.1-t4.1",
"type": "measurement_of",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s9-t1",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r5-t1.1-t2.1",
"type": "measures",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r6-t1.1-t2.1",
"type": "evaluation_of",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s5-r7-t2.1-t4.1",
"type": "measurement_of",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s8-r1-t2.1-t3.1",
"type": "uses",
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"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s8-r2-t2.1-t3.1",
"type": "performs",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerNervenarzt.80690507.eng.abstr-s8-r3-t3.1-t2.1",
"type": "affects",
"arg1_id": "DerNervenarzt.80690507.eng.abstr-s8-t3",
"arg2_id": "DerNervenarzt.80690507.eng.abstr-s8-t2",
"normalized": []
}
] |
DerNervenarzt.80690516.eng.abstr
|
DerNervenarzt.80690516.eng.abstr
|
[
{
"id": "DerNervenarzt.80690516.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 67-year-old lady with breast cancer developed diplopia , tinnitus , nausea and vertigo within 2 weeks , followed 2 months later by severe truncal ataxia . Opsoclonus was never observed . She had anti-Ri antibodies and improved substantially after tumor resection and radiation ."
],
"offsets": [
[
0,
280
]
]
}
] |
[
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"breast"
],
"offsets": [
[
24,
30
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006141"
},
{
"db_name": "UMLS",
"db_id": "C0006142"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cancer"
],
"offsets": [
[
31,
37
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"diplopia"
],
"offsets": [
[
48,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012569"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"tinnitus"
],
"offsets": [
[
59,
67
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040264"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"nausea"
],
"offsets": [
[
70,
76
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027497"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"vertigo"
],
"offsets": [
[
81,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042571"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"ataxia"
],
"offsets": [
[
148,
154
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004134"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"breast cancer"
],
"offsets": [
[
24,
37
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006142"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"truncal ataxia"
],
"offsets": [
[
140,
154
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0427190"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Opsoclonus"
],
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[
157,
167
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242567"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"antibodies"
],
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[
205,
215
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003241"
}
]
},
{
"id": "DerNervenarzt.80690516.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"tumor"
],
"offsets": [
[
249,
254
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
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[] |
[] |
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DerNervenarzt.80690519.eng.abstr
|
DerNervenarzt.80690519.eng.abstr
|
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"Primary intracranial germ cell tumors are rare neurological diseases . Secreting germ cell tumors that predominantly appear in the pineal region are characterized by elevated levels of -HCG and AFP in CSF . Adequate diagnostic and therapeutic regimens of these tumors are still under debate . We present the case of a patient suffering from spinal metastasis of a secreting germ cell tumor with raised levels of -HCG in CSF . Six years before , a pineocytoma of intermediate differentiation had been diagnosed by stereotaxic biopsy . This demonstrates the importance of an early detection of a germ cell neoplasm in case of midline-sized brain-tumors by evaluation of -HCG and AFP in CSF and serum . Today , different therapeutic strategies depending on the histological diagnosis are available and justify a high priority of a surgical tumor biopsy . However , the value of stereotaxic procedures remains controversial . Recently published data gave evidence of a definite improved prognosis of secreting CNS germ cell tumors following combined treatment with high-dose polychemotherapy , surgical resection and radiation of the tumor area . -HCG and AFP may serve as useful markers to enable follow-up of the disease ."
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] |
DerNervenarzt.80690525.eng.abstr
|
DerNervenarzt.80690525.eng.abstr
|
[
{
"id": "DerNervenarzt.80690525.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 1991 the diagnosis of cerebral circulatory arrest with Doppler sonography was accepted by the Medical Council of the Bundesaerztekammer as one of the methods able to shorten the waiting time for fulfilling the criteria for diagnosis of cerebral death . A survey was undertaken to determine how frequently Doppler sonography has been used since that time in certifying brain death . A total of 400 questionnaires were sent out to all neurological ( 272 ) and neurosurgical ( 128 ) departments in Germany . In all , 226 questionnaires were returned . In 71 departments , Doppler sonography has been used to certify brain death , mostly combined with other methods . The question of whether false positive results have been observed was answered five times in the affirmative . The background to these cases was clarified by telephone calls . In order to indicate pitfalls , the examiners reported borderline situations which in part did not fulfil the prerequisites . In none of these cases had the diagnosis of brain death been based on ultrasound data . Doppler sonography for the diagnosis of cerebral circulatory arrest has been used by a considerable number of neurological and neurosurgical departments in Germany as an additional confirmatory test and rather seldom as the only method to shorten the waiting period ."
],
"offsets": [
[
0,
1324
]
]
}
] |
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DerNervenarzt.80690530.eng.abstr
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DerNervenarzt.80690530.eng.abstr
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DerNervenarzt.80690543.eng.abstr
|
DerNervenarzt.80690543.eng.abstr
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[
{
"id": "DerNervenarzt.80690543.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The clinical picture of adult hyperkinetic syndrome ( HKS ) or attention deficit/hyperactivity disorder is nearly unknown in Germany . It can be estimated , that approximately one third of affected children also show symptoms as adults . In the combined type of the syndrome symptoms of inattention as well as of hyperactivity and impulsivity are present , a predominantly inattentive or hyperactive-impulsive type is possible . Retrospective diagnosis of HKS in childhood can be difficult . Disorganization , emotional disturbances and stress intolerance are common in adults with HKS as well as residual symptoms of learning disorders like dyslexia , dyscalculia and dysgraphia . In differential diagnosis especially affective , anxiety and antisocial personality disorders have to be considered , for which on the other side a frequent comorbidity with HKS is known . There is strong evidence for genetic transmission . Neurobiological findings revealed dysregulation of neurotransmitters . For treatment stimulants as pemoline and methamphetamin are effective , in addition tricyclic antidepressants or beta blockers ; positive effects are probable for moclobemide , bupropion , fluoxetine and venlafaxine ."
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DerNervenarzt.80690557.eng.abstr
|
DerNervenarzt.80690557.eng.abstr
|
[
{
"id": "DerNervenarzt.80690557.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the course of a 5-year follow-up study concerning comorbidity in opiate addicts , 350 patients were investigated initially in various addiction centres in Hamburg . More than two thirds of the participants of the study are male , with an average age of 29 years at the time of the investigation . Most of them are receiving methadone maintenance treatment ( 42% ) , about one fourth is in residential rehabilitation and another 17% in inpatient detoxification treatment . The patients have been consuming heroin for an average of 9 years . For 55% of the opiate addicts ( at least ) one more psychic disorder in accordance with ICD-10 has been diagnosed ( lifetime prevalence ) . F6 personality disorders have not been taken into consideration . The 6-month prevalence is 37% , 2-week prevalence 23% . For 43% of the opiate addicts , the predominant disorders belong to the group of neurotic , endurance , and somatoform disorders ( F4), and for 32% of the patients to the group of affective disorders ( F3). Schizophrenic , schizotypic and delusional disorders ( F2) are less frequent ( 5% ) . Another 5% of the opiate addicts suffer from eating disorders ( F5). These are partly multiple diagnoses cases ; there is an average of 1.3 diagnoses per patient . Women are clearly more often affected by comorbidity than men . Most disorders first occur between the age of 18 and 21 years . Therefore , ( lifetime ) prevalence rates are twice to three times as high as that of the average German population , according to the present state of knowledge . This underlines the great importance of specific diagnostic and explorative methods for the treatment of addiction . Psychic disorders or disturbances that might adversely affect the course of treatment should be given more consideration ."
],
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0,
1793
]
]
}
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DerNervenarzt.80690574.eng.abstr
|
DerNervenarzt.80690574.eng.abstr
|
[
{
"id": "DerNervenarzt.80690574.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The neurobiological alterations commonly found in affective disorders ( e.g. , alterations in the nocturnal sleep profile , dysfunction of the hypothalamic-pituitary-adrenocortical system ) gradually recover with improvement of the depressive syndrome . Their persistence during full clinical remission , however , is associated with an increased risk for relapse and , thus may represent trait markers for affective disorders . In order to test this hypothesis , we designed a prospective study in which healthy first-degree relatives ( high-risk probands ; HRPs ; n=54) of patients with an affective disorder are investigated by means of polysomnography , the combined dexamethasone and corticotropine-releasing hormone ( DEX-CRH ) test and a variety of psychometric scales . In the present part of the study ( index assessment ) , these HRPs , as a group , showed depressionlike alterations in both the sleep pattern and the DEX-CRH-test outcome ; furthermore , their psychometric profile was characterized by elevated scores on the scales assessing \" rigidity \" and \" autonomic lability \" . On a single-case level , 35% of the HRPs were identified as conspicuous ( depressionlike ) in at least two of the three areas investigated . A decision of whether or not this \" conspicuousness \" indeed represents a trait marker for affective disorders can be reached when the follow-up part of the study has identified those HRPs with their respective premorbide status who have developed an affective disorder in the meantime ."
],
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0,
1523
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]
}
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] |
[] |
[] |
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DerNervenarzt.80690586.eng.abstr
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DerNervenarzt.80690586.eng.abstr
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"Three short , respectively promising self-rating scales used for the assessment of emotional states , especially depression , were examined : a visual analogue scale with only five items , a short version of the so-called \" adjectives list \" and a differentiated scale for recording current emotions , possible susceptibility to them and the ability to express them . We checked statistical parameters of item analysis , reliability , validity and time course measurement . This study was carried out with depressive inpatients ( n=35) at the time of admission and 4 weeks later in beginning remission . All three scales proved to be reliable ( Cronbach- between 0.48 and 0.97 ) and partially very valid instruments ( concurrent validity between 0.04 and 0.87 ) . In order to improve the documentation of a beginning response to therapeutic efforts , separate recordings of depressive subsyndromes such as \" impetus \" or \" positive emotionality \" seem to be quite promising approaches ."
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DerNervenarzt.80690600.eng.abstr
|
DerNervenarzt.80690600.eng.abstr
|
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"Long-term course of depression appears to be clearly correlated to marital quality and quality of the relationship with spouses . Aim of the present study is the replication of results , indicating that expressed emotion ( EE ) is an important factor in prediction of relapse in depression . Additionally , the correlation between EE shown by spouses and the severeness of depressive symptomatology as well as the importance of marital quality as seen by patients for relapse are investigated . Results of our study indicate that spouses EE does not predict relapse , and status of EE does not correlate with the extent of depressive symptoms . However , patient self ratings of satisfaction with marital relationship and of perceived criticism are related to relapse frequency . Additionally , discrepant ratings of marital satisfaction given by spouses predict relapse to some extent . Implications for research in affective disorders and clinical practice are discussed ."
],
"offsets": [
[
0,
974
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]
}
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[] |
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DerNervenarzt.80690609.eng.abstr
|
DerNervenarzt.80690609.eng.abstr
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"Within the context of an extensive study of electroconvulsive therapy at the Psychiatric Clinic of the University of Bonn 15 patients suffering from therapy-resistent Major depression ( DSM III-R ) were examined with a detailed psychometric test battery , containing memory- and nonmemory tests . The test battery had been applied short time before , during and after the treatment with 10 ECT applied unilateral over the nondominant hemisphere . Comparing the test performances before and 1-2 days after the end of the series there were only few remarkable changes : a significant decrease was diagnosed exclusively in 30 min delayed recall of verbal items , while visual short-term memory and visual-constructive performance showed a significant improvement ( in spite of unilateral stimulation on the right side ) . None of the other cognitive functions inclusively speed of performances and reaction time was detracted short time after the end of the ECT-treatment , instead all the measures improved albeit not significantly . Between responders to treatment ( 50% improvement in HAMD ) and non-responders no significant differences neither before nor after the treatment were detected . The non-responders had in nearly all of the tests some better ( but not significantly ) results despite being older than the group of responders ."
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[] |
[] |
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{
"id": "DerNervenarzt.80690609.eng.abstr-s4-r5-t1.1-t4.1",
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}
] |
DerNervenarzt.80690617.eng.abstr
|
DerNervenarzt.80690617.eng.abstr
|
[
{
"id": "DerNervenarzt.80690617.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the past 30 years electroconvulsive therapy ( ECT ) was rarely applied in Germany mostly due to political reasons . Now ECT gains more interest again among psychiatrist as an effective somatic treatment for severe psychoses . Non-response to antidepressive medications is considered as one of the major indications for ECT . However , there are only few reports in the literature concerning the use of ECT in the treatment of late-life depression . Here we report on our experience with ECT treatment of older depressive patients ( mean age 69 +/- 5 years ) not responding to different antidepressants before ECT . There was a marked clinical improvement in 9 of the 12 ( 75% ) cases ( reduction of the Hamilton Depression Score to less than 50% ) . The only serious complication occurring in the sample was a transient cardiac conduction delay . Our experience show that ECT is a safe treatment also for late-life depression , which should be applied more often to avoid chronification of depression ."
],
"offsets": [
[
0,
1005
]
]
}
] |
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21,
38
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"id": "DerNervenarzt.80690617.eng.abstr-s1-t2",
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"therapy"
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39,
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]
},
{
"id": "DerNervenarzt.80690617.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ECT"
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49,
52
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"Germany"
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"ECT"
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"medications"
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}
] |
[] |
[] |
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{
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{
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{
"id": "DerNervenarzt.80690617.eng.abstr-s5-r5-t6.1-t5.2",
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{
"id": "DerNervenarzt.80690617.eng.abstr-s5-r6-t5.1-t7.1",
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"id": "DerNervenarzt.80690617.eng.abstr-s5-r8-t2.1-t7.1",
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{
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{
"id": "DerNervenarzt.80690617.eng.abstr-s5-r10-t5.1-t1.1",
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"arg2_id": "DerNervenarzt.80690617.eng.abstr-s8-t1",
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},
{
"id": "DerNervenarzt.80690617.eng.abstr-s5-r11-t5.2-t2.1",
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"id": "DerNervenarzt.80690617.eng.abstr-s7-r1-t2.1-t1.1",
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{
"id": "DerNervenarzt.80690617.eng.abstr-s7-r2-t1.1-t2.1",
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DerNervenarzt.80690622.eng.abstr
|
DerNervenarzt.80690622.eng.abstr
|
[
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"id": "DerNervenarzt.80690622.eng.abstr-passage-0",
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"In our study on Psychiatry , Mass Media and Public Opinion we made a content analysis of newspaper reports on ECT and electric defibrillation . We traced only few special articles on the subject in the 1994 and 1995 CD . Rom versions of the \" Der Spiegel \" , The \" Frankfurter Allgemeine Zeitung \" ( FAZ ) , the \" Neue Zuercher Zeitung \" ( NZZ ) and the \" Berliner Tageszeitung \" ( taz ) , although the word \" Elektroschock \" was employed 118 times . Even in high standard newspapers the style of language becomes special when they deal with ECT . The articles are strongly biased and lack informations . In contrast to Defibrillation ECT is not generally accepted . Referring to ECT horror pictures of past psychiatry are cited . The language used is biased and discriminative . Referring to Defibrillation technical details are described and the language is neutral . The social representation of ECT is completely negative ."
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0,
927
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] |
[] |
[] |
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"id": "DerNervenarzt.80690622.eng.abstr-s4-r2-t1.2-t4.1",
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}
] |
DerNervenarzt.80690629.eng.abstr
|
DerNervenarzt.80690629.eng.abstr
|
[
{
"id": "DerNervenarzt.80690629.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Selective serotonin reuptake inhibitors ( SSRI ) are known to exhibit far less cardiac side effects than tricyclic antidepressants . We report three cases in which the SSRI , paroxetine , induced clinically relevant ECG changes in patients with high risk profile . In two cases an increase in QTc time was observed , severe bradycardia was also observed twice ."
],
"offsets": [
[
0,
361
]
]
}
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{
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10,
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"id": "DerNervenarzt.80690629.eng.abstr-s1-t2",
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"db_id": "C0162758"
}
]
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"paroxetine"
],
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[
175,
185
]
],
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"db_id": "C0070122"
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},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-t2",
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"text": [
"ECG"
],
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216,
219
]
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"db_id": "C0013798"
}
]
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
231,
239
]
],
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}
]
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"risk"
],
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[
250,
254
]
],
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{
"db_name": "UMLS",
"db_id": "C0035647"
}
]
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"time"
],
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[
297,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"bradycardia"
],
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[
324,
335
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0428977"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r1-t1.1-t7.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r2-t1.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r3-t5.1-t7.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r4-t1.1-t4.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r5-t1.1-t5.1",
"type": "complicates",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r6-t2.1-t7.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r7-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r8-t1.1-t5.1",
"type": "causes",
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"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
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},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r9-t1.1-t5.1",
"type": "affects",
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"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r10-t2.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r11-t5.1-t4.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r12-t2.1-t5.1",
"type": "causes",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r13-t2.1-t5.1",
"type": "affects",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r14-t2.1-t4.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r15-t5.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r16-t5.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r17-t5.1-t1.1",
"type": "produces",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s1-t5",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s1-r18-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-r1-t2.1-t4.1",
"type": "measures",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-r2-t2.1-t1.1",
"type": "analyzes",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-r3-t2.1-t3.1",
"type": "affects",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-r4-t4.1-t2.1",
"type": "evaluation_of",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s2-t4",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerNervenarzt.80690629.eng.abstr-s2-r5-t3.1-t2.1",
"type": "performs",
"arg1_id": "DerNervenarzt.80690629.eng.abstr-s2-t3",
"arg2_id": "DerNervenarzt.80690629.eng.abstr-s3-t2",
"normalized": []
}
] |
DerNervenarzt.80690639.eng.abstr
|
DerNervenarzt.80690639.eng.abstr
|
[
{
"id": "DerNervenarzt.80690639.eng.abstr-passage-0",
"type": "abstract",
"text": [
"S100B is a multifunctional member of the S100-calmodulin-troponin superfamily of proteins and can modulate the activity of other intracellular proteins following binding of calcium . S100B has been shown to exhibit regulatory effects on cell growth and differentiation as well as on cell shape and energy metabolism . S100B has neurotrophic properties and stimulates glial cell proliferation in vitro and in vivo . Overexpression of S100B has been proposed as a pathogenetic factor in plaque formation in patients with Alzheimer's disease and Down syndrome . Furthermore , S100B-specific T-lymphocytes have been shown to be encephalitogenic in the animal model of experimental autoimmune panencephalitis ( EAP ) . Phenotypically and functionally similar S100B-specific T-cells can also be recovered from the peripheral blood of humans making S100B a potential candidate autoantigen in multiple sclerosis . Here the basic biochemical , molecular and functional properties of S100B are reviewed with special regard to the potential pathogenetic role of S100B in Alzheimer's disease , Down syndrome and multiple sclerosis ."
],
"offsets": [
[
0,
1120
]
]
}
] |
[
{
"id": "DerNervenarzt.80690639.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"proteins"
],
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[
81,
89
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"proteins"
],
"offsets": [
[
143,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"binding"
],
"offsets": [
[
162,
169
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243122"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"calcium"
],
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[
173,
180
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006675"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"exhibit"
],
"offsets": [
[
207,
214
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015272"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"regulatory"
],
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[
215,
225
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220905"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
237,
241
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"growth"
],
"offsets": [
[
242,
248
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018270"
},
{
"db_name": "UMLS",
"db_id": "C0220844"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
283,
287
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"metabolism"
],
"offsets": [
[
305,
315
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025519"
},
{
"db_name": "UMLS",
"db_id": "C0025520"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"cell growth"
],
"offsets": [
[
237,
248
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007595"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"cell shape"
],
"offsets": [
[
283,
293
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162657"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"energy metabolism"
],
"offsets": [
[
298,
315
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014272"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
373,
377
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"glial cell"
],
"offsets": [
[
367,
377
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027836"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"in vitro"
],
"offsets": [
[
392,
400
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021135"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"plaque"
],
"offsets": [
[
485,
491
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011389"
},
{
"db_name": "UMLS",
"db_id": "C0333463"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
505,
513
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"disease"
],
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[
531,
538
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"syndrome"
],
"offsets": [
[
548,
556
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"Down syndrome"
],
"offsets": [
[
543,
556
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013080"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"animal"
],
"offsets": [
[
648,
654
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003043"
},
{
"db_name": "UMLS",
"db_id": "C0003062"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"EAP"
],
"offsets": [
[
706,
709
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013995"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"animal model"
],
"offsets": [
[
648,
660
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0599779"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
819,
824
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"humans"
],
"offsets": [
[
828,
834
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020114"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"autoantigen"
],
"offsets": [
[
870,
881
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004359"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"sclerosis"
],
"offsets": [
[
894,
903
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036429"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"multiple sclerosis"
],
"offsets": [
[
885,
903
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026769"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"role"
],
"offsets": [
[
1043,
1047
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035820"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
1072,
1079
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerNervenarzt.80690639.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"syndrome"
],
"offsets": [
[
1087,
1095
]
],
"normalized": [
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] |
DerNervenarzt.80690660.eng.abstr
|
DerNervenarzt.80690660.eng.abstr
|
[
{
"id": "DerNervenarzt.80690660.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Kennedy-Syndrome is a X-linked recessive bulbospinal muscular atrophy , in some cases associated with endocrinological disturbances such as androgen resistance and diabetes mellitus . The age of onset is usually between 20 and 40. Presenting symptoms are proximal flaccid weakness , fasciculations , cramps or tremor . Disease progression is usually slow and live expectancy is normal . It is important to distinguish the Kennedy-Syndrome from amyotrophic lateral sclerosis , spinal muscular atrophy , muscular dystrophies and other types of motor neuron disease . Kennedy disease is caused by an expanded trinucleotide repeat in the androgen receptor gene . Genetic analysis allows a precise diagnosis on an individual basis and reliable genetic counselling . An effective medical treatment does not yet exist ."
],
"offsets": [
[
0,
816
]
]
}
] |
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"id": "DerNervenarzt.80690660.eng.abstr-s1-t2",
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{
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] |
DerNervenarzt.80690666.eng.abstr
|
DerNervenarzt.80690666.eng.abstr
|
[
{
"id": "DerNervenarzt.80690666.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To clarify the functional mechanism of the Esmarch device in the treatment of sleep apnea , its effect on muscle activity during sleep was studied electromyographically with and without the appliance at the inferior head of the lateral pterygoid muscle , the genioglossal muscle , and the masseter muscle in 15 patients with sleep apnea syndrome . During the obstructive apnea the muscles showed significantly lower amplitudes than before the apnea . No significant decrease in the amplitude was observed during the central apnea , but , after the obstructive and central apnea , significantly higher amplitudes were seen than beforehand . The amplitudes rose after the placement of the appliance , and the amplitudes of the genioglossal and lateral pterygoid muscles during obstructive apnea increased significantly after the insertion of the appliance . The results suggest that the device can activate the masticatory and tongue muscle activity and indicate that the muscles activated with the appliance can prevent obstruction in the oropharynx . The Esmarch device not only helps avoid obstruction by mandibular protraction , but also affects function by activating the muscles ."
],
"offsets": [
[
0,
1184
]
]
}
] |
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{
"id": "DerNervenarzt.80690666.eng.abstr-s1-t3",
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"id": "DerNervenarzt.80690666.eng.abstr-s1-t9",
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DerNervenarzt.80690671.eng.abstr
|
DerNervenarzt.80690671.eng.abstr
|
[
{
"id": "DerNervenarzt.80690671.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We investigated 88 Patients with a total of 102 angiographically diagnosed intracranial aneurysms by means of transcranial colour coded Duplex sonography ( TCCD ) during a time period of 15 months . Both the size and teh localization of teh aneuryms were determined . Seventy aneurysms ( 77% ) with a diameter of 16 +/- 8 mm ( 6-55mm) were detectable , with excellent visualization in 36 ( 42% ) , moderate visualization in 34 ( 40% ) , and no sufficient visualization in 16 ( 16% ) aneurysms , respectively . In another 16 cases ( 16% ) there was no sufficient vone window . Thrombotic material inside the aneurysm was detectable in 16/20 cases ( 75% ) , visualization of coil embolized aneurysms in 12/25 patients ( 48% ) . TCCD allows the follow up of cerebral aneurysms , with the detection of thrombosis and treatment effects after embolization . The method is not valid for the detection of intracranial aneurysms"
],
"offsets": [
[
0,
919
]
]
}
] |
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DerNervenarzt.80690683.eng.abstr
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DerNervenarzt.80690683.eng.abstr
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"Magnetic resonance imaging represents today the most important tool in neuroradiology for both clinical pratice and research . MRI allows imaging of the human body in 2 or 3 dimensions with variable tissue contrast . The natural diffusion of tissue protons can now be used as a supplementary contrast mechanism . Different MRI techniques can be used to obtain clinically useful diffusion-weighted images . These techniques all require the use of strong gradient pulses in order to obtain the diffusion contrast . In the current article , the most important physical principles of diffusion measurement are presented . After a short introduction into the basic physical principles , we will present the prerequisites and limitations of clinically relevant applications today . Finally a few select examples of clinical use of these techniques in the acute diagnosis of stroke will be presented ."
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] |
DerNervenarzt.80690694.eng.abstr
|
DerNervenarzt.80690694.eng.abstr
|
[
{
"id": "DerNervenarzt.80690694.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Neuroborreliosis is a very frequent subtype of infection with Borrelia burgdorferi . Because of the widely spread inapparent infections finding of diagnosis by analysis of serum antibodies is very difficult . In the years 1990-1994 the serum of 6.775 patients of the Department of Neurology in Homburg , Germany was analysed with regard to Borrelia burgdorferi specific IgG antibodies . 24% showed a positive serum titer and 20% a borderline result . 73 patients showed a specific intrathecal IgG antibody synthesis . In contrast to patients with antibodies in serum these patients showed a significant cumulation during summer . The high percentage of positive serum titers and the season independence support the assumption of widely spread inapparent infections . If a patient shows neurological symptoms the finding of serum antibodies against Borrelia burgdorferi is not sufficient for the diagnosis of Neuroborreliosis . A specific intrathecal synthesis of antibodies , is the most reliable serological indicator for Neuroborreliosis . Intrathecal synthesis usually starts three to four weeks after the first clinical symptoms ."
],
"offsets": [
[
0,
1134
]
]
}
] |
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"id": "DerNervenarzt.80690694.eng.abstr-s3-t2",
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}
] |
[] |
[] |
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DerNervenarzt.80690702.eng.abstr
|
DerNervenarzt.80690702.eng.abstr
|
[
{
"id": "DerNervenarzt.80690702.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In primary pseudotumor cerebri ( PTC ) intracranial pressure is elevated by so far unknown mechanisms . There is a wide range of clinical courses . Therapy is controversial . We present a case of PTC with acute visual loss . After optic nerve sheath decompression a relapse occured . A 30-year old female patient experienced visual loss within 48 h accompanied by headache and slight neck stiffness . Visual acuity was 1/50 in the right eye ; in the left eye just hand movements and light were perceived . Fundoscopy revealed a 9 dptr . prominent optic disc bilaterally . After optic nerve sheath decompression ( ONSD ) she improved , but underwent a relapse after 3 months . Twenty-four-hour measurement of intracranial pressure revealed elevated values . As a consequence ventriculo-peritoneal shunting was performed , leading to prominent improvement . Primary PTC can cause acute visual loss . If conservative treatment fails , different surgical procedures should be considered ."
],
"offsets": [
[
0,
984
]
]
}
] |
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DerNervenarzt.80690707.eng.abstr
|
DerNervenarzt.80690707.eng.abstr
|
[
{
"id": "DerNervenarzt.80690707.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Wernicke's encephalopathy ( WE ) is a consequence of vitamin B1 ( thiamine ) deficiency and in the majority of cases due to alcoholism . We report here the case of a 26-year-old male alcoholic who had stayed helplessly at home for 4 days until hospital admission . Clinical diagnosis was difficult due to major disturbance of consciousness . MRI showed an increase in signal intensity ( T2-, FLAIR-weighted ) around the third ventricle , the quadrigeminal bodies , the fornices , the mamillary bodies , the floor of the fourth ventricle and around the aqueduct . These findings were indicative of WE although of unusual extent . In this case MRI correlated well with clinical symptomatology . Therapy with thiamine was started immediately and symptoms as well as MRI findings resolved partially . The presented case illustrates the diagnostic usefulness of MRI in WE especially if the patient is of reduced consciousness and clinical investigation is limited ."
],
"offsets": [
[
0,
960
]
]
}
] |
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DerNervenarzt.80690717.eng.abstr
|
DerNervenarzt.80690717.eng.abstr
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[] |
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DerNervenarzt.80690728.eng.abstr
|
DerNervenarzt.80690728.eng.abstr
|
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{
"id": "DerNervenarzt.80690728.eng.abstr-passage-0",
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"This review of German neurology during the Nazi era mentions first the significance of Jewish neurologists for the history of the specialty , and the irreplaceable loss that their expulsion from Germany represented . A brief discussion of the scientific accomplishments of German neurologists during this time is followed by a description of violations of ethical principles , exemplified by the human experiments of G. Schaltenbrand . The spirit of the age exerted a malevelent influence ."
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[] |
[] |
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DerNervenarzt.80690737.eng.abstr
|
DerNervenarzt.80690737.eng.abstr
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"Long-term treatment of patients with chronic schizophrenias requires integration of many therapeutic approaches , co-operation of several professions , and regard for the views of patients and relatives . This review deals with practical aspects of pharmacotherapy , psychotherapy , cognitive resp. psychological treatments , social resp. milieu therapy , rehabilitation , interventions based on the concept of Expressed Emotions ( EE ) , psychoeducation and work with relatives . Continuous neuroleptic treatment is indispensable in most cases to achieve social integration . Indications for adding on antidepressants , lithium , carbamazepine , benzodiazepines and other drugs are discussed , as well as treatment of negative symptoms , depression and management of treatment-resistant symptoms . Psychotherapy needs to regard the possibilities of the patient . In the context of a stable long-term relationship , the patient is supported in experiencing himself as a subject capable of action . Effectiveness of cognitive treatments to date is limited . The best results are achieved by social skills training . Social therapy , which aims at the improvement of functional aspects of the patient , is of paramount importance . Improved possibilities for work rehabilitation are contrasted by difficulties in financing long-term social rehabilitation . Interventions based on the EE concept are highly effective , but are rarely used . Programs that merely convey information without targeting behaviour modification are ineffective . The functions of facilities of treatment in the community are explained , the integrative role of case-management is stressed ."
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] |
DerNervenarzt.80690752.eng.abstr
|
DerNervenarzt.80690752.eng.abstr
|
[
{
"id": "DerNervenarzt.80690752.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Microglia are the resident macrophages of the brain . They are the central cellular element to initiate defense mechanisms against destructive environmental influences and to facilitate regenerative processes . No other cell type of the brain is endowed with a comparably comprehensive , immunocompetent machinery like microglia . It encompasses cell proliferation , migration and differentiation into full-blown macrophages able to present antigen and to phagocytose cell debris . Relatively little is known about these stages of microglia activation on the cellular and molecular level , although microglia have been described as a separate cell type of the brain as early as in the 30ies of this century by P. del Rio Hortega . This review summarizes the data that have accumulated until now in this respect and tries to embed them into a clinical framework . Special focus has been given to the role of this cell type in the development and progression of Multiple Sclerosis , HIV-associated dementia and Alzheimer's disease ."
],
"offsets": [
[
0,
1030
]
]
}
] |
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"id": "DerNervenarzt.80690752.eng.abstr-s4-t4",
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"antigen"
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] |
[] |
[] |
[
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] |
DerNervenarzt.80690769.eng.abstr
|
DerNervenarzt.80690769.eng.abstr
|
[
{
"id": "DerNervenarzt.80690769.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a comparison of extreme groups 124 german inhabitants of the city of Mannheim were investigated . They descended from a representative sample with 600 persons out of 3 years of birth ( 1935 , 1945 , 1955 ) in the general population ( psychotic disorders were excluded ) . They were within a period of 10 years either in stable mental health or in chronic illness . The comparison between this two groups concerned demographic variables , development during childhood , personality , stressfull life events , social network and clinical data . The ascertained prevalence is 12,7% ( from n=600) for stable mental health and 3,5% for chronic illness . The group with the highest risk of chronic diseases is those of women and men with bad achievement and small social competence ."
],
"offsets": [
[
0,
780
]
]
}
] |
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{
"id": "DerNervenarzt.80690769.eng.abstr-s2-t1",
"type": "umlsterm",
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"persons"
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154,
161
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},
{
"id": "DerNervenarzt.80690769.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"birth"
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{
"id": "DerNervenarzt.80690769.eng.abstr-s2-t3",
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"id": "DerNervenarzt.80690769.eng.abstr-s2-t4",
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"text": [
"psychotic"
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"disorders"
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"id": "DerNervenarzt.80690769.eng.abstr-s3-t1",
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"id": "DerNervenarzt.80690769.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"health"
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}
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{
"id": "DerNervenarzt.80690769.eng.abstr-s3-t3",
"type": "umlsterm",
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"mental health"
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330,
343
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}
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"id": "DerNervenarzt.80690769.eng.abstr-s3-t4",
"type": "umlsterm",
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"chronic illness"
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{
"id": "DerNervenarzt.80690769.eng.abstr-s4-t1",
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"development"
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}
]
},
{
"id": "DerNervenarzt.80690769.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"personality"
],
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}
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},
{
"id": "DerNervenarzt.80690769.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"life"
],
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},
{
"id": "DerNervenarzt.80690769.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"social network"
],
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511,
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}
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},
{
"id": "DerNervenarzt.80690769.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"prevalence"
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{
"id": "DerNervenarzt.80690769.eng.abstr-s5-t2",
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"mental health"
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"id": "DerNervenarzt.80690769.eng.abstr-s5-t4",
"type": "umlsterm",
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"id": "DerNervenarzt.80690769.eng.abstr-s6-t1",
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"id": "DerNervenarzt.80690769.eng.abstr-s6-t2",
"type": "umlsterm",
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"diseases"
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{
"id": "DerNervenarzt.80690769.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"women"
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{
"id": "DerNervenarzt.80690769.eng.abstr-s6-t4",
"type": "umlsterm",
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"id": "DerNervenarzt.80690769.eng.abstr-s6-t5",
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"db_name": "UMLS",
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}
]
}
] |
[] |
[] |
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DerNervenarzt.80690776.eng.abstr
|
DerNervenarzt.80690776.eng.abstr
|
[
{
"id": "DerNervenarzt.80690776.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The result of an investigation of 128 from 283 ( 45,2% ) medical and psychological psychotherapists established in the city of Hannover is presented . The aim of the study is to characterize the situation of psychotherapeutical care not only by the number of psychotherapists in relation to inhabitants but also by the working time spent for psychotherapy . Besides we found gender , school of psychotherapy and professional experience as factor influencing the patients waiting time for beginning a psychotherapy . In contrast to other studies , the number of medical and psychological psychotherapists is not different , nevertheless the psychotherapeutical care in Hannover is not ensured ."
],
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[
0,
693
]
]
}
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"id": "DerNervenarzt.80690776.eng.abstr-s3-t3",
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] |
[] |
[] |
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"id": "DerNervenarzt.80690776.eng.abstr-s2-r1-t1.1-t2.1",
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"id": "DerNervenarzt.80690776.eng.abstr-s2-r2-t2.1-t1.1",
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{
"id": "DerNervenarzt.80690776.eng.abstr-s3-r3-t3.1-t4.1",
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"id": "DerNervenarzt.80690776.eng.abstr-s3-r4-t4.1-t6.1",
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{
"id": "DerNervenarzt.80690776.eng.abstr-s3-r5-t6.1-t4.1",
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"id": "DerNervenarzt.80690776.eng.abstr-s3-r7-t6.1-t2.1",
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{
"id": "DerNervenarzt.80690776.eng.abstr-s3-r8-t3.1-t2.1",
"type": "uses",
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"arg2_id": "DerNervenarzt.80690776.eng.abstr-s4-t2",
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{
"id": "DerNervenarzt.80690776.eng.abstr-s3-r9-t4.1-t3.1",
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"arg2_id": "DerNervenarzt.80690776.eng.abstr-s3-t3",
"normalized": []
}
] |
DerNervenarzt.80690782.eng.abstr
|
DerNervenarzt.80690782.eng.abstr
|
[
{
"id": "DerNervenarzt.80690782.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A mental hospital and a psychiatric department of a general hospital in the region of Kassel have jointly analysed their basic documentation to produce an overview of hospital treatment of psychiatric patients in the region . Patients from the urban population occupy twice as many beds as those from the rural population which is a hint that standard bed-ratios per population are inadequate . Instead of the unsuitable official definition of duration of stay in hospital we used \" days in hospital per person per year \" . Making allowance for groups of diagnoses this made possible interesting comparisons about the contributions of the two hospitals to the treatment of the psychiatric patients in the region . The two hospitals are not similar and the results show how the patients make use of the possibility of choosing the various specialities of the two hospitals ."
],
"offsets": [
[
0,
873
]
]
}
] |
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9,
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{
"id": "DerNervenarzt.80690782.eng.abstr-s1-t2",
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68
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}
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{
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127,
140
]
],
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"id": "DerNervenarzt.80690782.eng.abstr-s1-t4",
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{
"id": "DerNervenarzt.80690782.eng.abstr-s1-t5",
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176,
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"db_name": "UMLS",
"db_id": "C0039798"
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{
"id": "DerNervenarzt.80690782.eng.abstr-s1-t6",
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201,
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{
"id": "DerNervenarzt.80690782.eng.abstr-s1-t7",
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2,
17
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{
"id": "DerNervenarzt.80690782.eng.abstr-s1-t8",
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52,
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},
{
"id": "DerNervenarzt.80690782.eng.abstr-s2-t1",
"type": "umlsterm",
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"Patients"
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[
226,
234
]
],
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]
},
{
"id": "DerNervenarzt.80690782.eng.abstr-s2-t2",
"type": "umlsterm",
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"id": "DerNervenarzt.80690782.eng.abstr-s2-t3",
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282,
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"id": "DerNervenarzt.80690782.eng.abstr-s2-t4",
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"id": "DerNervenarzt.80690782.eng.abstr-s2-t6",
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{
"id": "DerNervenarzt.80690782.eng.abstr-s2-t7",
"type": "umlsterm",
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{
"id": "DerNervenarzt.80690782.eng.abstr-s2-t8",
"type": "umlsterm",
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DerNervenarzt.80690791.eng.abstr
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DerNervenarzt.80690791.eng.abstr
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"Starting with the recommendations of the \" Psychiatrie-Enquête \" , a current empirical stock-taking was undertaken about the structure of care in psychiatric hospital units . 319 treatment units ( 289 in Germany , 11 in Austria , and 19 in Switzerland ) were investigated concerning size of the treatment unit , number of wards , centrality of admission , existence of large observation rooms ( \" Wachsaele \" ) , spezialized wards , single sex wards , regionalization/sectorization , open-door wards , coercive measures , and intended structural changes . The return rate of questionnaires amounted 59% . The results show that the recommendations of the \" Psychiatrie-Enquête \" are mostly realized today , but not everywhere . Across countries differences resulted in size of ward , centrality of admission , open-door wards , and coercive measures . Treatment units in the western and eastern parts of germany differed in size of ward and centrality of admission . Differences between psychiatric hospitals , psychiatric departments at general hospitals and psychiatric university hospitals were , though significant , smaller than expected in the light of past controversies . Intended structural changes mainly concerned open-door wards , internal sectorization , decentralization of admission , and mixing the sexes in single sex wards ."
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DerNervenarzt.80690806.eng.abstr
|
DerNervenarzt.80690806.eng.abstr
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"id": "DerNervenarzt.80690806.eng.abstr-passage-0",
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"After the exploration of the psychiatric patient by a medical student in the context of a small psychiatric teaching-group ( Psychiatric Clinic , University of Muenster ) was finished , both medical students and patients ( n=94 each ) were asked about their experiences during that interview by means of a special questionnaire : Most patients reported about positive effects of the educational interview . 60% of the patients spoke about a positive prove of regained strength , 35% gained new or deeper insights . On the other hand 10% of the patients made worrying and unpleasant experiences . Students diminished their anxiety to hurt patients by asking too intimate questions . 30 to 40% of the students reported about difficulties in structuring a clinical interview , especially with patients who refused to talk or didn ' t answer the students ' questions correctly . 60% of the students made also emotional learning experiences ."
],
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0,
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] |
DerNervenarzt.80690811.eng.abstr
|
DerNervenarzt.80690811.eng.abstr
|
[
{
"id": "DerNervenarzt.80690811.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The concept of a posttraumatic stress disorder ( PTSD ) has become important for psychiatric diagnosis and research , particularly following US-american studies on Vietnam war veterans . Recently , studies on traindrivers involved in suicide accidents have shown symptoms of anxiety and depression in more than 30% of concerned drivers and typical symptoms of a PTSD in 15% . Here , we present the case of a traindriver who was involved in 6 suicide accidents within 17 years of traindriving ( the average is 2 suicide accidents ) . Following the 3rd accident , the driver developed increasingly symptoms like anxiety , sleep disturbances , flashbacks and irritability . Following the 6th accident , he has been unable to work . A former expert opinion saw no relationship between the symptoms of the driver and the suicide accidents . Therefore , further information about the concept of a PTSD seems necessary to ensure early psychotherapeutic and pharmacological treatment of patients with such a disorder ."
],
"offsets": [
[
0,
1010
]
]
}
] |
[
{
"id": "DerNervenarzt.80690811.eng.abstr-s1-t1",
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"stress"
],
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[
31,
37
]
],
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}
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},
{
"id": "DerNervenarzt.80690811.eng.abstr-s1-t2",
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"disorder"
],
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[
38,
46
]
],
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"db_id": "C0012634"
}
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},
{
"id": "DerNervenarzt.80690811.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"PTSD"
],
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49,
53
]
],
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{
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{
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{
"id": "DerNervenarzt.80690811.eng.abstr-s1-t6",
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"text": [
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DerNervenarzt.80690815.eng.abstr
|
DerNervenarzt.80690815.eng.abstr
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[
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"It is reported about the recent detection of not yet compensated victims of forced sterilisation during the Third Reich . The author describes the current state of compensation practice ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
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164,
176
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DerNervenarzt.80690818.eng.abstr
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DerNervenarzt.80690818.eng.abstr
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"id": "DerNervenarzt.80690818.eng.abstr-passage-0",
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"We are reporting on a patient with a schizoaffective disorder ( ICD 10 : F25.1), whose catatonic symptoms deteriorated while receiving high-potency neuroleptic drugs in combination with anticholinergic medication . Initially there was a \" catatonic dilemma \" , i.e. it was not possible to differentiate between the morbigenous and pharmacogenic ( malignant neuroleptic syndrome ) etiology of the catatonic symptoms . Catatonic symptoms were successfully treated with a combination of lorazepam and clozapine . The severe catatonic syndrome was found to be a neuroleptic-induced deterioration of a primary morbogenous catatonic syndrome . Thus , this case also suggests that the malignant neuroleptic syndrome and neuroleptic non-responsive catatonia may not be two different disease entities but that catatonia under neuroleptic medication is caused by the interaction of individual disposition , morbigenous and pharmacogenic factors ."
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DerNervenarzt.80690835.eng.abstr
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DerNervenarzt.80690835.eng.abstr
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"Valproate is a frequently used antiepileptic drug . It is associated with rare but serious adverse effects like liver failure . The first symptom is impairment of the patient's well being . Isolated changes of standard laboratory liver parameters are not reliable early indicators . Thus , according to the knowledge of today , prophylactic blood screening cannot predict complications . On the contrary , clinical symptoms are the most relevant indicators of impending complications , eventually supported by laboratory findings . An abrupt withdrawl of valproate and administering carnitin in parallel can interrupt the otherwise fatal course of the complication and induce a subsequent recovery . At a Consensus Conference the current knowledge about early detection and therapy of the valproate-induced serious hepatotoxicity was discussed . The results regarding recommended laboratory screening , as well as diagnostic and therapeutic strategies are reported ."
],
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0,
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}
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[] |
[] |
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DerNervenarzt.80690851.eng.abstr
|
DerNervenarzt.80690851.eng.abstr
|
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[] |
[] |
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DerNervenarzt.80690858.eng.abstr
|
DerNervenarzt.80690858.eng.abstr
|
[
{
"id": "DerNervenarzt.80690858.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Seventy-nine patients with chronic neuromuscular diseases were examined by psychodiagnostic tests . The most frequently used coping strategies were \" compliance and confidence in the physician \" , \" self encouragement \" , \" to relative by comparison \" and \" problem-solving \" . Comparison of the test sample and our total sampling group and the groups divided by diagnosis showed more common features than differences in the coping process . This might be caused by similar general problems in chronic diseases . Less \" compliance and confidence in the physician \" was the only significant difference between the myasthenic patients and the remaining test group . We supposed less treatment possibilities and/or longer duration of illness ( remaining test group ) to be responsible for this result . Duration of illness in common seems to have an influence on coping . Patients suffering a longer illness showed reduced values in \" self encouragement \" . Common and specific problems and circumstances of illness seem to be more significant for the coping process than the diagnosis . The patients ' mood , which we took as a measure for partial aspects of adaptivity of coping , correlated significantly with the strength of the complaints felt . Classification into adaptive and maladaptive coping forms is not possible ."
],
"offsets": [
[
0,
1323
]
]
}
] |
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DerNervenarzt.80690864.eng.abstr
|
DerNervenarzt.80690864.eng.abstr
|
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[] |
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DerNervenarzt.80690879.eng.abstr
|
DerNervenarzt.80690879.eng.abstr
|
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"id": "DerNervenarzt.80690879.eng.abstr-passage-0",
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"text": [
"The long-standing consultant service for neurological patients in a general hospital requires questions to about the dimensions and efficiency of being answered cooperation between a general hospital and a neighbouring neurological clinic with a casualty ward and neuroradiology . From 1987 to 1995 , 1471 patients with neurological diagnoses were observed retrospectively . The small number of requested consultancies ( 4-5% ) was conspicious related to the total member of patients treated in the general hospital . About 25% of the recommendations of the consultants were realized . The percentage of pensioners and housewives was distinctly higher ( 45% ) . With the help of the diagnosis \" concussion of the brain \" good cooperation was observed between the general physicians to whom the consultant's recommendations had been passed on and the neurological casualty ward . The results , tendencies and possibilities for improvement of interdisciplinary cooperation are discussed ."
],
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0,
986
]
]
}
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[] |
[] |
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DerNervenarzt.80690886.eng.abstr
|
DerNervenarzt.80690886.eng.abstr
|
[
{
"id": "DerNervenarzt.80690886.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a total of 30 tremor patients ( 14 with Parkinson's disease , 6 with cerebellar tremor , 4 with essential tremor , 4 with psychogenic tremor , 2 with enhanced physiological tremor ) , tremor was electromyographically recorded before , during and after contralateral distraction tasks ( tapping with the index finger or the tip of the foot , sequential flexion of the 2nd to 5th finger towards the thumb , \" keyboarding \" , and sensory discrimination ) . 22 of 26 patients with organic tremors spontaneously choose a volitional tapping frequency independent from their tremor frequency . In 4 patients with psychogenic tremor , frequencies of tremor and tapping were locked ( n=3), or tremor disappeared abruptly ( n=1) when contralateral tapping was started . Contralateral \" keyboarding \" and sensory discrimination revealed no clear differences between organic and psychogenic tremors . Contralateral tapping in further 23 patients ( 22 with organic tremors and 1 with psychogenic tremor ) confirmed these findings . Contralateral tapping appears as the most valid distraction task and may help to differentiate psychogenic from organic tremors ."
],
"offsets": [
[
0,
1151
]
]
}
] |
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] |
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