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DerNervenarzt.00710442.eng.abstr
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DerNervenarzt.00710442.eng.abstr
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[
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"id": "DerNervenarzt.00710442.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Diseases of the peripheral nervous system occur in up to 50% of persons infected with human immunodeficiency virus ( HIV ) . In early stages of the infection , Guillain-Barré syndrome or a spontaneously remitting mononeuropathy can occur . The most frequent occurrence is distal symmetrical polyneuropathy associated with HIV , which can only be treated symptomatically . The most important differential diagnosis is a drug-induced polyneuropathy under antiretroviral therapy with the nucleoside analogues DDI , DDC , or D4T. Chronic inflammatory demyelinating polyneuropathy is less common and can be treated with immunoglobulins or corticosteroids . Very rare are steroid-responsive neuropathies with necrotizing vasculitis or in diffuse infiltrative lymphocytosis syndrome ( DILS ) . In the AIDS stage , polyradiculitis can occur due to opportunistic infections - most often with cytomegalovirus ( CMV ) or M. tuberculosis - or polyradiculopathies due to lymphomatous meningiosis . Mononeuritis multiplex is rarely seen in disseminated CMV infection . Myopathies can occur in all stages of HIV infection ; their frequency is about 1% . Primary polymyositis associated with HIV , which can be treated with corticosteroids or immunoglobulin , must be distinguished from myopathy induced by azidothymidine . Other forms of myopathy are very rare ."
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}
] |
[] |
[] |
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] |
DerNervenarzt.00710451.eng.abstr
|
DerNervenarzt.00710451.eng.abstr
|
[
{
"id": "DerNervenarzt.00710451.eng.abstr-passage-0",
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[] |
[] |
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DerNervenarzt.00710459.eng.abstr
|
DerNervenarzt.00710459.eng.abstr
|
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{
"id": "DerNervenarzt.00710459.eng.abstr-passage-0",
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[] |
[] |
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"id": "DerNervenarzt.00710459.eng.abstr-s1-r7-t1.1-t2.1",
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DerNervenarzt.00710470.eng.abstr
|
DerNervenarzt.00710470.eng.abstr
|
[
{
"id": "DerNervenarzt.00710470.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A total of 314 hands of patients suffering from carpal tunnel syndrome ( CTS ) in pregnancy or puerperium were treated by carpal tunnel release . In 53% of these cases , other members of the family were also affected , usually the mother . Ninety-seven patients were operated upon at both hands . One hundred thirty-three operations were performed during pregnancy , mostly in the last trimester , and 181 during puerperium . In four patients , the operation was performed on both hands simultaneously . There were also 12 cases of associated De Quervain's tenosynovitis and ten trigger fingers . Severe night pain and/or permanent hypoesthesia was experienced by 93% of the patients . All patients were operated on with local anesthesia and in a bloodless field . The distal motor latency was 7 +/- 1.5 ms in cases with hypoesthesia and 4.9 +/- 1.75 ms without sensory loss . Of the patients , 98% reported good or excellent results of the operation during pregnancy via questionnaires ."
],
"offsets": [
[
0,
988
]
]
}
] |
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DerNervenarzt.00710474.eng.abstr
|
DerNervenarzt.00710474.eng.abstr
|
[
{
"id": "DerNervenarzt.00710474.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Of 1310 patients surgically treated for carpal tunnel syndrome ( CTS ) , 134 ( 10.2% ) were observed to have one or more trigger fingers or de Quervain's disease . Of a total of 205 fingers , the middle finger was affected 75 times , the ring finger 50 times , the thumb 47 times , the small finger 17 times , and the index finger 16 times . Chronic nonspecific synovitis is commonly suspected as the cause of both diseases . In all cases of carpal tunnel syndrome , the patient should therefore be examined for symptoms of concomitant trigger finger and vice versa . Both can be cured surgically under local anesthesia and bloodless field in a single session ."
],
"offsets": [
[
0,
661
]
]
}
] |
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},
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"id": "DerNervenarzt.00710474.eng.abstr-s2-t4",
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DerNervenarzt.00710477.eng.abstr
|
DerNervenarzt.00710477.eng.abstr
|
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"text": [
"Epileptic activity can modulate reactions of the autonomic nervous system . Although there is some evidence of a differential left/right hemispheric influence on the cardiovascular system , diverse investigations have shown controversial results . In our study , complex partial seizures of patients with temporal lobe epilepsy were recorded using subdural electrodes , thus providing reliable information on the focus side . We analyzed the preictal and ictal heart rates of 27 patients , 16 revealing right and 11 revealing left temporal foci . During the seizures , both groups showed a significant increase in heart rate . Preictal tachycardia was only significant in the right focus group , whereas no significant change in heart rates could be detected in the left focus group . Our results confirm a right hemispheric lateralization of sympathetic cardiac control ."
],
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[
0,
872
]
]
}
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DerNervenarzt.00710481.eng.abstr
|
DerNervenarzt.00710481.eng.abstr
|
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"id": "DerNervenarzt.00710481.eng.abstr-passage-0",
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"text": [
"The diagnosis of the rare disease Gliomatosis cerebri requires the correlation of clinical , radiological , and pathological findings . We report on two patients with intravitally diagnosed gliomatosis cerebri . Due to the unusually high malignancy of the tumor cells , diagnosis was complicated by atypical findings such as gadolinium enhancement in MRI and raised intracranial pressure . The clinical course , differential diagnosis , and literature are summarized briefly ."
],
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0,
476
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]
}
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[] |
[] |
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DerNervenarzt.00710495.eng.abstr
|
DerNervenarzt.00710495.eng.abstr
|
[
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"Topiramate ( Topamax ) has been registered since July 1998 and has market authorization for the Federal Republic of Germany as an additive drug for the treatment of patients ( age 12 or older ) suffering from intractable partial and secondarily generalized seizures . The anticonvulsant effect of topiramate is based on three mechanisms : ( a ) modulating the blocking of the Na channels activated by voltage , depending on status , ( b ) potentiation of GABAA-mediated inhibiting neurotransmission , and ( c ) inhibition of excitatory neurotransmission by blocking APMA glutamate receptors . Topiramate exhibits a substantial anticonvulsive effect on partial seizures both with and without secondary generalization . The median reduction in seizure frequency using topiramate as adjunct therapy was 44% . In 44% of patients , seizure frequency was reduced by more than 50% , and seizure reduction was more than 75% in nearly half of these ( i.e. , in 21% of all patients ) , while 5% of patients remained completely free of seizures . Adverse events most often caused central nervous disturbances . Weight loss , the development of renal calculi , and impairment of cognitive functions may occur . It is recommended to start therapy with topiramate at a daily dosage of 25 mg , increasing by 25 mg every week up to 200-400 mg/day but not exceeding 1000 mg/day ."
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DerNervenarzt.00710502.eng.abstr
|
DerNervenarzt.00710502.eng.abstr
|
[
{
"id": "DerNervenarzt.00710502.eng.abstr-passage-0",
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"Acute cerebral nerve paresis can be caused in many different ways . One of the more rare causes of paresis of one or more neural pathways is dissection of the internal carotid artery . Early diagnosis is important , even with atypical symptoms , since prompt anticoagulative therapy can hinder stroke from embolism due to the dissection . We report on two patients with Raeder's syndrome and Collet-Sicard syndrome resulting from dissection of the internal carotid artery . Besides the cranial and caudal nerves involved in our study , loss of function has also been reported with the sixth to eighth cranial nerves , so that any painful , sudden cranial nerve deficiency can indicate possible carotid dissection ."
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0,
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[] |
[] |
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DerNervenarzt.00710518.eng.abstr
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DerNervenarzt.00710518.eng.abstr
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"Changes and growing uncertainty about the professional identity of Dutch psychiatrists can already be recognized in the early years following World War II . This is illustrated by a quotation from H. C. Ruemke taken from his speech in 1954 entitled \" A Flourishing Psychiatry in Danger . \" Thus the stage was set for the central theme of this article concerning the mental health care system typical for the Netherlands and the development of multidisciplinary teams . In anticipation of the present situation , some future prognoses are also mentioned from K. P. Kisker's \" A Prognosis of Therapeutic Practice in Psychiatry \" ( German : \" Prognose der psychiatrischen Therapeutik \" ) of 1973 in the opening section as background to the question : from today's point of view and in the face of scientific developments threatening the field , how does the need for identity and continuity in psychiatry relate to social , sociopolitical , and cultural factors ?"
],
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[
0,
960
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]
}
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}
] |
DerNervenarzt.00710525.eng.abstr
|
DerNervenarzt.00710525.eng.abstr
|
[
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"id": "DerNervenarzt.00710525.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the last 10 years , comorbidity has become an important topic in psychiatric research , leading to a growing number of publications . We discuss the theoretical and historical background of this development and present definitions and models for the phenomenon . Methodological difficulties have to be stated : considering its clinical consequences , we conclude that ( 1 ) comorbidity is an inevitable methodological consequence of the diagnostic strategies and continued diversification of DSM-IV and ICD-10, ( 2 ) there is little doubt of its relevance in the clinical context , and ( 3 ) the diagnostic strategies of DSM-IV and ICD-10 concerning comorbidity are difficult to follow in clinical reality ."
],
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0,
714
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}
] |
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] |
[] |
[] |
[] |
DerNervenarzt.00710535.eng.abstr
|
DerNervenarzt.00710535.eng.abstr
|
[
{
"id": "DerNervenarzt.00710535.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The present paper reports lifetime prevalence rates of mental disorders in the 18- to 64-year-old general population of a northern German region . A representative random sample from registration office files of 4,075 individuals was examined in personal interviews using the fully standardized and computerised \" Munich Composite International Diagnostic Interview \" ( M-CIDI ) . The response rate was 70.2% . Individuals were classified according to the DSM-IV . Substance use disorders were most frequent with 25.8% followed by anxiety ( 15.1% ) , somatoform ( 12.9% ) , affective ( 12.3% ) , and eating disorders ( 0.7% ) . Disorders other than substance use were more frequent in women and less frequent in men . A trend toward less psychiatric morbidity exists in individuals with higher educational level , higher income , and those who are married or reside in rural communities . Of all individuals affected by mental disorders , 42% fulfilled the criteria for at least one additional disorder . The results are discussed against the background of selected previous studies ."
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0,
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t1",
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t2",
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t3",
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t4",
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t6",
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"id": "DerNervenarzt.00710535.eng.abstr-s5-t7",
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"id": "DerNervenarzt.00710535.eng.abstr-s6-t3",
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"id": "DerNervenarzt.00710535.eng.abstr-s6-t4",
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"id": "DerNervenarzt.00710535.eng.abstr-s7-t4",
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"id": "DerNervenarzt.00710535.eng.abstr-s7-t5",
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] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710535.eng.abstr-s1-r1-t5.1-t3.1",
"type": "degree_of",
"arg1_id": "DerNervenarzt.00710535.eng.abstr-s7-t5",
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},
{
"id": "DerNervenarzt.00710535.eng.abstr-s1-r2-t1.1-t3.1",
"type": "causes",
"arg1_id": "DerNervenarzt.00710535.eng.abstr-s8-t1",
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},
{
"id": "DerNervenarzt.00710535.eng.abstr-s1-r3-t1.1-t5.1",
"type": "causes",
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DerNervenarzt.00710543.eng.abstr
|
DerNervenarzt.00710543.eng.abstr
|
[
{
"id": "DerNervenarzt.00710543.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The aim of this study was to ascertain to what extent homeless , mentally ill subjects in Munich take advantage of available psychosocial services . To obtain a representative picture of the situation , the first step was to ascertain how many people in Munich are actually homeless . The next step was to ascertain what proportion of them are in need of psychotherapy . Using the standardized Diagnostic Interview Schedule ( DIS ) , 146 men and 32 women were interviewed . The results according to the DSM-III demonstrated high lifelong and 6-month prevalence of psychic disturbances . Medical and social services were often enjoyed , but mostly over a short period of time in particularly critical situations . Continued treatment rarely followed . Women were treated more often than men . Elements such as age and level of education hardly influenced patients ' seeking help . Despite a high prevalence of addictive disease , alcohol and drug clinics were rarely consulted . The increase in the number of diagnoses was paralleled by an increase in the number of patients seeking help . Most treatments involved schizophrenia and anxiety . By means of logistic regression models , predictors of the extent to which these services were used were analysed . We conclude that new clinical models are needed and that the aversion to the present care system is too great . Continued treatment occurs only rarely ."
],
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[
0,
1410
]
]
}
] |
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] |
[] |
[] |
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] |
DerNervenarzt.00710552.eng.abstr
|
DerNervenarzt.00710552.eng.abstr
|
[
{
"id": "DerNervenarzt.00710552.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A sample of 507 social work students completed the Bulimic Investigatory Test Edinburgh ( BITE ) . Simulating diagnoses according to DSM-IV criteria , we found three women suffering from bulimia nervosa ( BN ) . This represents a total prevalence of 0.6% , 0.8% in women , and 0.9% in female probands up to the age of 30 years . In the same way , we identified one case of anorexia nervosa ( AN ) , i . e . a total prevalence of 0.2% , 0,3% in women , and 0.3% in female probands up to the age of 30. Nineteen students also fulfilled DSM-IV research criteria for binge-eating disorder ( BED ) , showing a total prevalence of 3.7% , 3.8% in women , 3.5% in men , and 4.3% in female probands up to the age of 30. Thus , BED is the most common eating disorder and also occurs in men . In light of the association between weight discontent and eating disorders , suggestions are made for the management of overweight patients and both normal and underweight clients with eating disorders ."
],
"offsets": [
[
0,
985
]
]
}
] |
[
{
"id": "DerNervenarzt.00710552.eng.abstr-s1-t1",
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],
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23,
27
]
],
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},
{
"id": "DerNervenarzt.00710552.eng.abstr-s1-t2",
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"text": [
"students"
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28,
36
]
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{
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"Test"
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73,
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{
"id": "DerNervenarzt.00710552.eng.abstr-s1-t4",
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"BITE"
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90,
94
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{
"id": "DerNervenarzt.00710552.eng.abstr-s1-t5",
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"social work"
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16,
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"criteria"
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"id": "DerNervenarzt.00710552.eng.abstr-s2-t2",
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"women"
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166,
171
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{
"id": "DerNervenarzt.00710552.eng.abstr-s2-t3",
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"text": [
"bulimia"
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187,
194
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{
"id": "DerNervenarzt.00710552.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"bulimia nervosa"
],
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187,
202
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DerNervenarzt.00710559.eng.abstr
|
DerNervenarzt.00710559.eng.abstr
|
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"In the discussion of increasing costs of health care in Germany , the frequent and long hospital stays of elderly patients are often pointed out . Since these patients very frequently suffer from psychiatric disorders , psychiatric consultation is often required . This study was aimed at investigating whether new German laws concerning guardianship and the structure of health care providers change conditions for psychiatric consultation services . For this purpose , the documentation of all consultations in the years 1991 to 1995 was retrospectively evaluated . In about 3% of all patients aged over 65 referred to the General University Hospital of Luebeck , psychiatric consultation was ordered . The most frequent diagnosis was senile dementia . Comparison of the requests and psychiatric recommendations show a significant increase in wishes and recommendations for guardianship . Moreover , there is evidence of the increasing need of consultation in elderly patients . Possibly due to the new law concerning the structure of health care providers and the number of requests and recommendations to transfer patients to psychiatric wards , these results show that the new laws do affect psychiatric consultation ."
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0,
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]
}
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[] |
[] |
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DerNervenarzt.00710573.eng.abstr
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DerNervenarzt.00710573.eng.abstr
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"id": "DerNervenarzt.00710573.eng.abstr-passage-0",
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"text": [
"In an earlier published study [ 16 , 17 , 18 ] , it was demonstrated that migraine sufferers have personality traits significantly more strongly associated with the typus melancholicus than healthy individuals and patients with other mental and physical illnesses . They display a fixation on tidiness which manifests itself in an excessive striving for quality and quantity in performance-oriented situations . The main features of their social relationships are excessive helpfulness combined with an exaggerated tendency towards guilt avoidance and symbiotic attachment to their own families . They do not differ from unipolar depressives in these respects . The major aim of the new study is to examine whether the concept of the typus melancholicus in relation to migraine sufferers as proposed in the first study is adaptable to explaining the personality characteristics of migraine sufferers ( \" typus migraenicus \" ) . Age-matched samples of 42 female migraine sufferers , 40 female patients with unipolar depression , and 41 female control subjects took part in the new study . The test instruments used were von Zerssen's Munich Personality Test ( MPT ) and a questionnaire specially designed by the first author for assessing the typus migraenicus ( German \" Fragebogen zur Erfassung des Typus migraenicus , \" or FETM ) . The results obtained using univariate and multivariate analyses demonstrate a confirmation of the typus migraenicus concept , although to a less pronounced degree than the previous study . This can be seen as supporting evidence that , independently of the study sample and the investigators , migraine sufferers display with higher random frequency a personality profile very similar to the premorbid personality structure in unipolar depressives ."
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DerNervenarzt.00710584.eng.abstr
|
DerNervenarzt.00710584.eng.abstr
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0,
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[] |
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DerNervenarzt.00710588.eng.abstr
|
DerNervenarzt.00710588.eng.abstr
|
[
{
"id": "DerNervenarzt.00710588.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hypothyroidism is one of the most important causes of potentially reversible dementia . The present case demonstrates a relatively rapid remission of cognitive and noncognitive symptoms within a period of a few months . For separating dementia in hypothyroidism from dementia with hypothyroidism , cross-sectional and longitudinal assessment of the clinical features is crucial . Various case studies in the literature have shown the reversibility of dementia in hypothyroidism and therefore indicate that the evaluation of thyroid laboratory parameters is indispensable in the differential diagnosis of dementia and observation of its course ."
],
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[
0,
644
]
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}
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DerNervenarzt.00710597.eng.abstr
|
DerNervenarzt.00710597.eng.abstr
|
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"Recent immunobiological findings together with advances in biotechnology , ameliorations in clinical trial design , and MRI developments have led to a variety of therapeutical approaches in multiple sclerosis ( MS ) . However , in contrast to successfully introduced new treatments , a number of therapeutical failures exist as well : despite impressive data from animal models , convincing concepts , and promising phase I/II studies , some investigated drugs and strategies showed no positive effects in clinical trials , or trials had to be terminated because of unexpected side effects . This article provides an overview of clinical studies that have failed or been abandoned for other reasons . Tumor necrosis factor ( TNF ) -antagonists which have led to negative effects in two studies ( Lenercept , Infliximab ) are discussed in detail . These results raise critical questions concerning the hypothetical pathogenesis of MS lesions and the value of MRI in the assessment of clinically relevant therapeutic drug effects . In addition to a description of the immunobiological background , studies on the immunosuppressive agents linomide , deoxyspergualin , sulfasalazine and cladribine , trials for the cytokines interleukin-10 and TGF-2, the studies on remyelination by intravenous immunoglobulins ( IVIg ) , oral tolerance , and extracorporeal photopheresis are discussed ."
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] |
DerNervenarzt.00710611.eng.abstr
|
DerNervenarzt.00710611.eng.abstr
|
[
{
"id": "DerNervenarzt.00710611.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Benign familial neonatal convulsions are a rare monogenic form of idiopathic epilepsy characterized by the onset of frequent brief seizures after the second day of life . The seizures disappear spontaneously within a few weeks , but recurrent seizures later in life are common . Linkage studies located genes to chromosome 20q13.3 and 8q24, and the voltage-gated potassium channels KCNQ2 and KCNQ3 were recently identified . Since then , several mutations have been found leading to haplosufficiency of the ion channel . Functional studies showed that KCNQ2 and KCNQ3 are able to contribute to a heteromeric channel exhibiting kinetic and pharmacological properties similar to those of the native M current , the latter playing an important role in the regulation of neuronal excitability . This overview presents a summary of the molecular , genetic , and electrophysiological findings and discusses them with respect to their clinical relevance ."
],
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[
0,
948
]
]
}
] |
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[] |
[] |
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DerNervenarzt.00710616.eng.abstr
|
DerNervenarzt.00710616.eng.abstr
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[
{
"id": "DerNervenarzt.00710616.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cortical dysgenesis comprises a heterogenous group of genetic or acquired disturbances of cortical development which , due to progress in modern neuroimaging techniques , are increasingly recognized in association with a variety of clinical disorders . The spectrum of clinical manifestations , depending on type and extent of the alterations , includes severe mental retardation and epilepsy as well as neuropsychological deficits and psychiatric disorders . Up to now , the nomenclature of cortical malformations has been difficult and ambiguous . Recently , the understanding and terminology of these disorders has been facilitated by the proposal of a new classification scheme based on pathophysiological as well as pathogenetic mechanisms . This proposal has been elaborated by a group of experts and is not yet well-known in the German literature . Magnetic resonance imaging ( MRI ) allows diagnosis and classification in many cases of cortical dysgenesis during lifetime , thereby helping to identify prognostic and therapeutic options . Early diagnosis of cortical malformations is of particular importance in patients with drug-resistant epilepsy , as they can either be cured or benefit from epilepsy surgery . This review gives examples of the most relevant cortical malformations using the new classification scheme and summarizes their clinical as well as MRI characteristics . Besides routine MRI applications , some experimental techniques are discussed which may help to identify even subtle alterations ."
],
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0,
1523
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DerNervenarzt.00710629.eng.abstr
|
DerNervenarzt.00710629.eng.abstr
|
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{
"id": "DerNervenarzt.00710629.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Little is known about the differential long-term outcome from surgical and nonsurgical therapy in patients with chronic epilepsy . In the present study , 161 surgically or nonsurgically treated patients with drug-resistant temporal lobe epilepsy ( TLE ) were re-evaluated according to a detailed clinical , neuropsychological , and psychosocial protocol with a mean follow-up interval of 58 months . Freedom from seizures was achieved in 64% of the surgical group ; yet 23% of the nonsurgical patients became seizure-free as a result of modifications in drug therapy . Generally , socioeconomic development was poorer in nonsurgical than in surgical patients . Freedom from seizures , employment , and the absence of depression were significant determinants of better quality of life . As for neuropsychological outcome , verbal memory impairment was common after left-sided temporal resection ; however , there was no evidence of a marked progression of cognitive impairment after the first postoperative year . In nonsurgical patients , too , cognitive capacities were surprisingly stable over time , although persisting seizures and good baseline performance predicted a poorer neuropsychological outcome ."
],
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[
0,
1209
]
]
}
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[] |
[] |
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] |
DerNervenarzt.00710643.eng.abstr
|
DerNervenarzt.00710643.eng.abstr
|
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"id": "DerNervenarzt.00710643.eng.abstr-passage-0",
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"text": [
"Olfactory dysfunction seems to be one of the most frequent symptoms in idiopathic parkinsonian syndrome ( IPS ) . In contrast to the increasing number of studies providing evidence of the usefulness of olfactory tests in the diagnosis of IPS , clinical assessment of olfactory function is rarely performed . This may be due to the lack of an easy-to-use , inexpensive , standardized , and reliable test . In this study , we administered the newly developed \" sniffin ' sticks \" test to a group of 40 nondemented IPS patients and compared the results with 40 healthy controls matched for age , gender , and smoking habits . In all three subtests including odor identification , odor detection threshold , and odor discrimination , the control group scored significantly better than the IPS group , yielding a specificity and sensitivity of 90% each . Our results indicate that olfactory disturbances in IPS can be found at early stages of the disease , appear bilaterally , and do not correlate with the dominant side of parkinsonism . Therefore , we emphasize that olfactory testing may be a useful tool in the diagnosis of IPS ."
],
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[
0,
1129
]
]
}
] |
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] |
[] |
[] |
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}
] |
DerNervenarzt.00710655.eng.abstr
|
DerNervenarzt.00710655.eng.abstr
|
[
{
"id": "DerNervenarzt.00710655.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Prolonged immobilization or physical inactivity has been shown to produce increased bone resorption due to enhanced osteoclastic activity and diminished bone formation . These skeletal changes are a typical complication in tetraplegic patients , who are at risk of developing hypocalcemia . Hypercalciuria is the most characteristic symptom ."
],
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[
0,
342
]
]
}
] |
[
{
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],
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10,
24
]
],
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}
]
},
{
"id": "DerNervenarzt.00710655.eng.abstr-s1-t2",
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"bone"
],
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]
],
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{
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],
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]
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},
{
"id": "DerNervenarzt.00710655.eng.abstr-s1-t4",
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],
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}
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},
{
"id": "DerNervenarzt.00710655.eng.abstr-s1-t5",
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"bone formation"
],
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153,
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]
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}
]
},
{
"id": "DerNervenarzt.00710655.eng.abstr-s2-t1",
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"complication"
],
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{
"id": "DerNervenarzt.00710655.eng.abstr-s2-t2",
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"id": "DerNervenarzt.00710655.eng.abstr-s2-t4",
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"id": "DerNervenarzt.00710655.eng.abstr-s2-t5",
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"risk of"
],
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257,
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{
"id": "DerNervenarzt.00710655.eng.abstr-s3-t1",
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],
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{
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}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710655.eng.abstr-s1-r1-t1.1-t2.1",
"type": "affects",
"arg1_id": "DerNervenarzt.00710655.eng.abstr-s3-t1",
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{
"id": "DerNervenarzt.00710655.eng.abstr-s1-r2-t1.1-t5.1",
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{
"id": "DerNervenarzt.00710655.eng.abstr-s2-r2-t4.1-t1.1",
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},
{
"id": "DerNervenarzt.00710655.eng.abstr-s2-r3-t1.1-t4.1",
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}
] |
DerNervenarzt.00710660.eng.abstr
|
DerNervenarzt.00710660.eng.abstr
|
[
{
"id": "DerNervenarzt.00710660.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hallervorden-Spatz disease ( HSD ) , a rare extrapyramidal motor illness , is usually only confirmed after death . In vivo diagnosis has relied hitherto on the combination of typical magnetic resonance imaging ( MRI ) findings ( the \" eye of the tiger \" sign ) and heterogeneous clinical symptoms of movement disorder which have been regarded as almost pathognomonic . We report on the diagnostic contribution of 123J--CIT single photon emission computed tomography ( SPECT ) and 123J-IBZM SPECT in akinetic-rigid Parkinson's syndrome occurring in a case of HSD . In contrast to Parkinson's disease and multisystem atrophies , the results of both tests were normal . This constellation of findings shows that the degeneration lies primarily outside the nigrostriatal system , supporting arguments for the nosologic distinction of HSD from other extrapyramidal illnesses ."
],
"offsets": [
[
0,
871
]
]
}
] |
[
{
"id": "DerNervenarzt.00710660.eng.abstr-s1-t1",
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"disease"
],
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{
"id": "DerNervenarzt.00710660.eng.abstr-s1-t2",
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"text": [
"death"
],
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]
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}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"Hallervorden-Spatz disease"
],
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0,
26
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018523"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
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123,
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"db_id": "C0011900"
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"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"magnetic"
],
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183,
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],
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"db_id": "C0024488"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"resonance"
],
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[
192,
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],
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"db_id": "C0459800"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t4",
"type": "umlsterm",
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],
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202,
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],
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}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t5",
"type": "umlsterm",
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"MRI"
],
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212,
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}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t6",
"type": "umlsterm",
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"findings"
],
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218,
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]
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"db_id": "C0243095"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"eye"
],
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[
235,
238
]
],
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{
"db_name": "UMLS",
"db_id": "C0015392"
},
{
"db_name": "UMLS",
"db_id": "C0496836"
},
{
"db_name": "UMLS",
"db_id": "C0023924"
}
]
},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"tiger"
],
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246,
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]
],
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"db_id": "C0325115"
}
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},
{
"id": "DerNervenarzt.00710660.eng.abstr-s2-t9",
"type": "umlsterm",
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"sign"
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DerNervenarzt.00710670.eng.abstr
|
DerNervenarzt.00710670.eng.abstr
|
[
{
"id": "DerNervenarzt.00710670.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recently , sudden \" sleep attacks \" have been described in parkinsonian patients taking the nonergoline dopamine agonists pramipexole and ropinirole . Due to this possible side effect , patients must be instructed not to drive vehicles and to refrain from other activities carrying the risk of self-injury . However , the very existence of sleep attacks remains controversial in sleep medicine , since a gradual transition from wakefulness to sleep is normally observed . Accordingly , sudden onset of sleep , e.g. , in narcolepsy or sleep apnea syndrome , is usually associated with excessive daytime sleepiness . Prevalence of sleep disorders and daytime sleepiness have been shown to be increased in Parkinson's disease . Nonergoline dopamine agonists are already known to induce somnolence . Currently , it is not predictable whether sleep attacks represent a sudden transition from wakefulness to sleep or result from an increased propensity to fall asleep , with patients perceiving a sudden onset . Possible pathophysiological mechanisms and legal implications of sleep attacks are discussed ."
],
"offsets": [
[
0,
1100
]
]
}
] |
[
{
"id": "DerNervenarzt.00710670.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"sleep"
],
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[
20,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037313"
}
]
},
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DerNervenarzt.00710677.eng.abstr
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DerNervenarzt.00710677.eng.abstr
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[
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"HIV-1-associated encephalopathy ( HIVE ) remains an important manifestation of advanced HIV infection despite recent progress in antiretroviral therapy . This is in part due to particular pharmacological and virological characteristics of the central nervous system ( CNS ) . HIVE is characterized by a \" subcortical \" dementia with psychomotor slowing as well as memory and concentration deficits . An invariable finding are deficits of central motor function . Pathogenetically , an enhanced viral replication in immunocompetent CNS cells is believed to be a requirement . This leads to neurotoxic effects directly elicited by viral products as well as indirectly by the immune response to virus infection . HIV-1 myelopathy ( HIVM ) is the other CNS manifestion of late HIV infection . The present consensus paper recommends diagnostic and therapeutic procedures in HIVE and HIVM and outlines the current research ."
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DerNervenarzt.00710691.eng.abstr
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DerNervenarzt.00710691.eng.abstr
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"The shift of psychiatric care from the hospital to the community has been accompanied by a reduction of hospital beds and shortened durations of inpatient treatment , but also by an increase in admissions . This evolution may be largely attributed to the prime focus of community mental health institutions on rehabilitation . The continued implementation of reforms in psychiatric care is contingent upon effectively halting the \" revolving door phenomenon \" by incorporating community-integrated treatment approaches into the care of acutely ill patients . Since the mid-1960s, a series of studies have established the efficacy of two community-integrated modalities for the treatment of acute psychiatric illness , i . e . home-based and day hospital treatment . In general , these approaches not only seem to be as effective as inpatient care for certain groups of patients but also reduce their need of hospitalisation , thereby contributing towards a cost effective , comprehensive psychiatric care system ."
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"This paper deals with ethical implications of neuroscientific research on patients as well as with the application of its results in diagnosis and treatment for brain diseases , in which a considerable demand for research exists due to their high frequency , long duration , disabling consequences , and unsatisfactory or nonexistent treatment possibilities . Such indispensable research on patients calls forth the basic ethical tension between respect of autonomy and dignity of the sick individual ( as well as the avoidance of somatic and psychic risks and burdens ) and the ethically justified demand for flawless research in recognizing , preventing , reducing , or eliminating disability and suffering caused by disease . The demand for research today also results from the increasing orientation of insurance companies towards scientifically proven evidence of the efficacy and safety of medical interventions : \" evidence-based medicine . \" This is illustrated by 3 examples : ( 1 ) use of fetal brain tissue/cells from planned abortions in patients in therapy-resistant final stages of Parkinson's disease and the effects of neurotransplantation on the recipients , ( 2 ) research with demented patients incompetent to give informed consent , and ( 3 ) predictive ( presymptomatic , prenatal ) testing in the genetic counseling of individuals from families with Huntington's chorea . We conclude that adherence to high ethical standards is of inestimable significance , not only for those participating in research but also for public acceptance of that research . This is particularly valid in Germany , where nonobservance and the undermining of ethical principles was grossly practiced in the first half of this century on the slippery descent into the abyss . Therefore , continued scrutiny with the increasing variety of ethical problems in medical research is demanded . However , this will be achieved not by taboos and prohibitive regulations but only through open discussion between scientists , particularly probands in research , patients ' relatives , and the public . This leads to four demands : listening honestly and openly , both in single cases and in the public sector , training in recognition and consideration of ethical problems , and reducing unfavorable conditions such as complex bureaucratic regulations , negative public views , overzealous efficiency , and insufficient time . Sufficient numbers of qualified personnel are needed who are trained in listening and who will have the time to do so ."
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DerNervenarzt.00710709.eng.abstr
|
DerNervenarzt.00710709.eng.abstr
|
[
{
"id": "DerNervenarzt.00710709.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The doctrine of informed consent has become a legal and ethical standard in psychiatry today . However , ethical problems arise if patients lose the capacity to give informed consent due to their psychiatric disorders . Particularly in the field of psychiatry , the assessment of competence of informed consent to medical treatment and participation in clinical trials is a controversial issue . New empirical data suggest that a high percentage of psychiatric patients are incompetent according to defined standards for assessing their capacity to make treatment decisions . Assessing competence according to a sliding scale integrates the ethical principles of autonomy and beneficence and provides help in assessing competence in clinical practice ."
],
"offsets": [
[
0,
752
]
]
}
] |
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}
] |
[] |
[] |
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"id": "DerNervenarzt.00710709.eng.abstr-s4-r1-t3.1-t1.1",
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},
{
"id": "DerNervenarzt.00710709.eng.abstr-s4-r2-t2.2-t3.1",
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},
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"id": "DerNervenarzt.00710709.eng.abstr-s5-r3-t5.1-t3.1",
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"id": "DerNervenarzt.00710709.eng.abstr-s5-r4-t1.1-t4.1",
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}
] |
DerNervenarzt.00710715.eng.abstr
|
DerNervenarzt.00710715.eng.abstr
|
[
{
"id": "DerNervenarzt.00710715.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To study the influence of alcohol and psychosocial variables on delinquent behavior , we coded data from the psychiatric evaluation of 254 defendants using a standardized score sheet , analyzing correlations between acute intoxication at the time of the crime ( ICD 10 : F10.0), diagnosis of alcohol dependency according to ICD 10 ( F10.2), psychobiographical variables , criminal history , and parameters relating to the index offence . We found that 64.6% of all defendants studied were intoxicated when committing the crime and 25.6% suffered from alcohol dependency . Alcohol intoxication correlated to occurrence of violent crime , cruelty in committing the index offence , and earlier convictions . Logistic regression , with demographic and psychosocial variables entered as covariables , revealed acute alcohol intoxication but not alcohol dependency as a predictor of violent crime ( odds ratio 2.3 , P=0.02). Alcohol intoxication and dependency were also independent predictors of earlier convictions ( intoxication , odds ratio 4.4 , P=0.0001; dependency , odds ratio 3.6 , P=0.003). Our findings support the hypothesis that acute alcohol intoxication , not dependency , influences violent crime in a direct manner . However , alcohol dependency predicts criminal recidivism ."
],
"offsets": [
[
0,
1287
]
]
}
] |
[
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t1",
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"text": [
"alcohol"
],
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26,
33
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"behavior"
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75,
83
]
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"db_name": "UMLS",
"db_id": "C0004927"
}
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t3",
"type": "umlsterm",
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"evaluation"
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121,
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"db_name": "UMLS",
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"intoxication"
],
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222,
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"db_name": "UMLS",
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{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t5",
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"time"
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242,
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{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t6",
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"crime"
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t7",
"type": "umlsterm",
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"diagnosis"
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279,
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"db_name": "UMLS",
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"alcohol"
],
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292,
299
]
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"dependency"
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300,
310
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t10",
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381,
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{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t11",
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"db_name": "UMLS",
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}
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s1-t12",
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"text": [
"psychosocial variables"
],
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38,
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"crime"
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"alcohol"
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551,
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"dependency"
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559,
569
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},
{
"id": "DerNervenarzt.00710715.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Alcohol"
],
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572,
579
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],
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]
},
{
"id": "DerNervenarzt.00710715.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"intoxication"
],
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580,
592
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],
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] |
DerNervenarzt.00710730.eng.abstr
|
DerNervenarzt.00710730.eng.abstr
|
[
{
"id": "DerNervenarzt.00710730.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a retrospective case control study at the University of Frankfurt , Germany , 101 babies born to opiate-addicted mothers were identified from birth charts from 1988 to 1995. After birth , they developed a withdrawal syndrome ( neonatal abstinence syndrome ) . Fifty control infants and their mothers were selected from neonatal wards . The group of opiate-exposed babies was subdivided into a group born to mothers without methadone treatment ( n=48) and a group born to mothers who were enrolled in a methadone program ( n=51). The methadone infants had a significantly higher mean birth weight ( 2822 g ) than children in the group without methadone ( 2471 g ) . The abstinence syndrome was much more intense in the methadone group ( convulsions 47.1% ) than in heroin-exposed babies without methadone treatment ( convulsions 27.1% ) . Women in methadone maintenance programs lived in more stable socioeconomic conditions than opiate-addicted women without methadone substitution . Moreover , they cared significantly better for their babies : 81.3% of the methadone mothers visited their children on a regular basis and 90.9% cared adequately . The data emphasize the need in future research to look more closely at the role of methadone treatment programs in the development of opiate-exposed babies ."
],
"offsets": [
[
0,
1308
]
]
}
] |
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DerNervenarzt.00710737.eng.abstr
|
DerNervenarzt.00710737.eng.abstr
|
[
{
"id": "DerNervenarzt.00710737.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Multiple chemical sensitivity ( MCS ) or idiopathic environmental intolerance ( IEI ) is understood as an acquired disorder with multiple recurrent symptoms that cannot be traced to any well-known medical or psychiatric condition and is associated with diverse environmental influences that are well tolerated by the majority of people . In a prospective study , we investigated 120 consecutive patients admitted a university-based outpatient department for environmental medicine during 1 year . Apart from routine medical examination and special toxicological diagnostic procedures , a structured clinical interview for DSM-IV psychiatric disorders was performed with every patient . At least one psychiatric diagnosis was found in 100 patients . The diagnostic criteria for somatoform disorders were filled by 53 patients . We found lifetime or current affective disorders in 39 patients , anxiety disorders in 29 , and substance dependency or abuse in 25. In 16 patients , personality disorders were diagnosed . Nine suffered from psychotic disorders . This is the largest prospective study with standardized psychiatric diagnostic methods concerning psychiatric morbidity and MCS . The data show that many patients with environmental health problems obviously suffer from somatoform disorders but also from other , well-known psychiatric conditions ."
],
"offsets": [
[
0,
1355
]
]
}
] |
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"id": "DerNervenarzt.00710737.eng.abstr-s2-t4",
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DerNervenarzt.00710745.eng.abstr
|
DerNervenarzt.00710745.eng.abstr
|
[
{
"id": "DerNervenarzt.00710745.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a special inpatient unit for detoxification treatment of illicit drugs , antagonist-induced opiate detoxification was studied in five nonselected inpatients with polytoxicomanic abuse . The purpose was to evaluate the feasibility of this detoxification method and its impact on further reaction to treatment . During rapid detoxification under general anesthesia in an intensive care unit , no complications occurred . Withdrawal symptoms were observed in all patients over several days . During the inpatient period , no patient could be motivated to take part in a longer rehabilitation therapy . Most patients were discharged prematurely on their own demand and none made use of the rehabilitation program offered to them . All patients relapsed after relatively short times and three out of five presented for a new detoxification treatment ."
],
"offsets": [
[
0,
849
]
]
}
] |
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DerNervenarzt.00710758.eng.abstr
|
DerNervenarzt.00710758.eng.abstr
|
[
{
"id": "DerNervenarzt.00710758.eng.abstr-passage-0",
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"Preclinical investigations suggest that the neuropeptide substance P might be involved in the etiopathology of pain , depression , and anxiety . In a recent study , the substance P receptor antagonist MK-869 showed antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI . The MK-869 was well tolerated . Although these findings are promising , further studies are necessary to prove the hypothesis that substance P receptor antagonists represent a new class of antidepressants or anxiolytics . Respective studies are currently underway ."
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586
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]
}
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[] |
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}
] |
DerNervenarzt.00710767.eng.abstr
|
DerNervenarzt.00710767.eng.abstr
|
[
{
"id": "DerNervenarzt.00710767.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Apoptosis , or programmed cell death , is a physiological cell suicide program mainly leading to selective elimination of useless cells . This mechanism is important for the homeostasis of the immune system and presumably plays a two-sided role in the pathogenesis of multiple sclerosis ( MS ) . On the one hand , evidence has been provided that impaired apoptosis might result in increased numbers or persistence of activated myelin-specific T cells , thus inducing the pathophysiologic processes in MS . On the other hand , local tissue damage might involve apoptosis of glial and neuronal cells and lead to the clinical symptoms . Here , an overview is presented on the current knowledge of the role of apoptosis in the pathogenesis of MS , and implications for related therapeutic strategies are discussed ."
],
"offsets": [
[
0,
811
]
]
}
] |
[
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"Apoptosis"
],
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0,
9
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{
"id": "DerNervenarzt.00710767.eng.abstr-s1-t2",
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],
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0,
9
]
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{
"id": "DerNervenarzt.00710767.eng.abstr-s1-t3",
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],
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0,
9
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}
]
},
{
"id": "DerNervenarzt.00710767.eng.abstr-s1-t4",
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"cell"
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26,
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"id": "DerNervenarzt.00710767.eng.abstr-s1-t5",
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"death"
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"cell"
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"id": "DerNervenarzt.00710767.eng.abstr-s1-t7",
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"suicide"
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63,
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"id": "DerNervenarzt.00710767.eng.abstr-s1-t9",
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"cells"
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{
"id": "DerNervenarzt.00710767.eng.abstr-s1-t10",
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"cell death"
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}
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{
"id": "DerNervenarzt.00710767.eng.abstr-s1-t11",
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"programmed cell death"
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"id": "DerNervenarzt.00710767.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"homeostasis"
],
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174,
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}
]
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"id": "DerNervenarzt.00710767.eng.abstr-s2-t2",
"type": "umlsterm",
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}
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"id": "DerNervenarzt.00710767.eng.abstr-s2-t3",
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"pathogenesis"
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"id": "DerNervenarzt.00710767.eng.abstr-s2-t4",
"type": "umlsterm",
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"sclerosis"
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"id": "DerNervenarzt.00710767.eng.abstr-s2-t5",
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"immune system"
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193,
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},
{
"id": "DerNervenarzt.00710767.eng.abstr-s2-t6",
"type": "umlsterm",
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"multiple sclerosis"
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"id": "DerNervenarzt.00710767.eng.abstr-s3-t1",
"type": "umlsterm",
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"hand"
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"id": "DerNervenarzt.00710767.eng.abstr-s3-t2",
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"id": "DerNervenarzt.00710767.eng.abstr-s3-t3",
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"myelin-specific"
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"id": "DerNervenarzt.00710767.eng.abstr-s3-t4",
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"cells"
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"id": "DerNervenarzt.00710767.eng.abstr-s3-t5",
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"T cells"
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"id": "DerNervenarzt.00710767.eng.abstr-s4-t2",
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]
}
] |
[] |
[] |
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DerNervenarzt.00710797.eng.abstr
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DerNervenarzt.00710802.eng.abstr
|
DerNervenarzt.00710802.eng.abstr
|
[
{
"id": "DerNervenarzt.00710802.eng.abstr-passage-0",
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"Rapid eye movement sleep behavior disorder ( RBD ) is a rare but clinically distinct disorder which is easily overlooked . It commonly occurs in older men and , because of its similarity to epileptic seizures , is often misdiagnosed . The etiology of RBD is still unknown . However , there is an interesting association with Parkinson's disease which presents some pathophysiological hypotheses . Treatment is usually successful with clonazepam ."
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446
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}
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[] |
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] |
DerNervenarzt.00710807.eng.abstr
|
DerNervenarzt.00710807.eng.abstr
|
[
{
"id": "DerNervenarzt.00710807.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The signs of narcolepsy have been known since the last century and the tetrad of symptoms was described 50 years ago : excessive sleepiness , cataplexy , sleep paralysis , and hallucinations . Polysomnography typically shows decreased sleep and REM sleep latency , and laboratory testing reveals a high association with the human leucocyte antigens ( HLA ) DQB1*0602 and DQA1*102. Acute studies suggest disturbances in the orexin ( hypocretin ) neurotransmitter system . However , the exact pathophysiology is still unclear . In Germany , about 1500 patients diagnosed with narcolepsy are known . The prevalence in Caucasian populations is estimated at 50/100 , 000. Thus , the number of undiagnosed patients is likely to be high ."
],
"offsets": [
[
0,
731
]
]
}
] |
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"id": "DerNervenarzt.00710807.eng.abstr-s2-t3",
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"id": "DerNervenarzt.00710807.eng.abstr-s2-t12",
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"id": "DerNervenarzt.00710807.eng.abstr-s2-t13",
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] |
[] |
[] |
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] |
DerNervenarzt.00710822.eng.abstr
|
DerNervenarzt.00710822.eng.abstr
|
[
{
"id": "DerNervenarzt.00710822.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A severe course of alcohol withdrawal has been observed in 28% of patients in a neurological intensive care unit due to complicating central nerve system ( CNS ) diseases . In any atypical alcoholic delirium , especially with focal neurological signs , partial seizures , or decreased level of consciousness , CNS diseases like meningoencephalitis , intracranial hemorrhage , or central pontine myelinolysis must be diagnosed by computed tomography ( CT ) scan and cerebral spinal fluid ( CSF ) tap . The diagnostic and prognostic value of CT scan and CSF analysis was examined in 32 persons with alcohol withdrawal syndrome or delirium tremens . Neurological complications and cerebral convulsions at the beginning of delirium tremens appear to predispose the patient to a protracted clinical course and necessary mechanical ventilation . Blood-CSF barrier permeability is increased in 70% of alcohol withdrawal patients and that also seems to be a marker of a prolonged clinical course . Cerebral atrophy as shown in CT scan does not play a role in predicting clinical course . In our experience , CT examination or lumbar puncture is not necessarily recommended if clinical signs are typical for alcohol delirium ."
],
"offsets": [
[
0,
1217
]
]
}
] |
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[] |
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] |
DerNervenarzt.00710829.eng.abstr
|
DerNervenarzt.00710829.eng.abstr
|
[
{
"id": "DerNervenarzt.00710829.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The experiences of a rural stroke unit since 1997 are reported . A special referral concept was developed with the emergency services and hospitals of the region . As a result , 35% of patients arrived in the stroke unit within 3 hours after onset of stroke symptoms . This corresponds with the data from larger cities . The major peculiarity of the Guenzburg Stroke Unit is that , after emergency diagnostic and therapeutic procedures , 41% of the patients with mainly internistic problems were transferred to another regional hospital and only 40% were admitted to the inpatient stroke unit . Moreover , among these were an above-average proportion of patients with intracerebral hemorrhage ( 24% of the inpatients in 1998 ) , and complete acute treatment and rehabilitation were carried out in the same hospital according to an integrative treatment concept . Since 1997 , the average hospitalization duration decreased from 11.4 days to 5.9 days and the number of patients per month increased to an average of 22.3. The total hospitalization duration - including inpatient rehabilitation - was 33.9 days . All in all , a comparably good stroke treatment thus is possible outside urban regions ."
],
"offsets": [
[
0,
1198
]
]
}
] |
[
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27,
33
]
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},
{
"id": "DerNervenarzt.00710829.eng.abstr-s2-t1",
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],
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[
75,
83
]
],
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},
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],
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115,
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] |
DerNervenarzt.00710835.eng.abstr
|
DerNervenarzt.00710835.eng.abstr
|
[
{
"id": "DerNervenarzt.00710835.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Spinocerebellar ataxia type 7 ( SCA7) belongs to the category of autosomal dominant cerebellar ataxias ( ADCA ) . The clinical picture is characterised by progressive ataxia and macular degeneration . Other common signs are slow saccades , external ophthalmoplegia , and pyramidal tract signs . The disease is caused by the expansion of an unstable CAG trinucleotide repeat in the gene for ataxin 7 on chromosome 3. SCA7 is a rare disorder . The first case in Germany was described only recently . We report two additional patients , father and son , with the molecular genetic diagnosis of SCA7. The father carries a trinucleotide expansion of 42 CAG repeats , the son 51. Normal alleles range from 7 to 35 CAG repeats . Both patients show the typical picture with progressive ataxia and macular degeneration . We found a pronounced anticipation ( earlier disease onset in subsequent generations ) , which is highly characteristic of CAG repeat disorders ."
],
"offsets": [
[
0,
957
]
]
}
] |
[
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"ataxia"
],
"offsets": [
[
16,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004134"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"ataxias"
],
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[
95,
102
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004134"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ADCA"
],
"offsets": [
[
105,
109
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006754"
},
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},
{
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"db_id": "C0050385"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Spinocerebellar ataxia"
],
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[
0,
22
]
],
"normalized": [
{
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"db_id": "C0087012"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s1-t5",
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"text": [
"cerebellar ataxias"
],
"offsets": [
[
84,
102
]
],
"normalized": [
{
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"db_id": "C0007758"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"ataxia"
],
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[
167,
173
]
],
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{
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}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"macular degeneration"
],
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[
178,
198
]
],
"normalized": [
{
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"db_id": "C0024437"
},
{
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}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"signs"
],
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[
214,
219
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"saccades"
],
"offsets": [
[
229,
237
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036019"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"ophthalmoplegia"
],
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249,
264
]
],
"normalized": [
{
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}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"signs"
],
"offsets": [
[
287,
292
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"external ophthalmoplegia"
],
"offsets": [
[
240,
264
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162292"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"pyramidal tract"
],
"offsets": [
[
271,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034229"
}
]
},
{
"id": "DerNervenarzt.00710835.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
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[] |
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] |
DerNervenarzt.00710839.eng.abstr
|
DerNervenarzt.00710839.eng.abstr
|
[
{
"id": "DerNervenarzt.00710839.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a case of autosomal dominantly inherited dystonia and panic attacks to discuss successful treatment of a common serotonergic pathology with medication . The objective analysis of the movement disorder was done by Optotrak©. First we demonstrate a reduction of the myoclonus by L-5-hydroxytryptophan, which inhibits after 11 months . After changing the medication to Nefadozone , the myoclonus and the frequency of panic attacks were reduced ."
],
"offsets": [
[
0,
452
]
]
}
] |
[
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{
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DerNervenarzt.00710849.eng.abstr
|
DerNervenarzt.00710849.eng.abstr
|
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"Oxcarbazepine ( OXC ; 10,11-dihydro-10-oxo-5H-dibenz-[b,f]azepin-5-carboxamid, trade name Trileptal ) is a new antiepileptic drug for treatment of mono- and adjunctive therapy of partial seizures with or without secondary generalization for adults and children above 6 years of age . It was developed through structural variation of carbamazepine . Extensive postmarketing use includes more than 200,000 patient years . The mechanism of action mainly involves blockage of sodium currents . The recommended daily starting dose of oxcarbazepine for both mono- and adjunctive treatment is 8-10 mg/kg ( 600 mg/day for adults ) in two doses and can be titrated according to clinical benefit up to 2400 mg/day . Oxcarbazepine undergoes reductive metabolism at its keto moiety to form MHD , which is glucuronidated and excreted in the urine , with minimal involvement of the hepatic cytochrome P450-dependent enzymes . Thus , OXC has limited drug interactions and does not require slow titration , allowing for better tolerability . Oxcarbazepine compares favorably to presently available new anticonvulsants of the second generation for two reasons : it is available immediately for both mono-and adjunctive therapy in adults and children , and extensive postmarketing experience from many countries is already available . In addition , OXC has been thoroughly tested in an unusually large clinical development program and been shown to be similarly effective as standard antiepileptic drugs ."
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[] |
[] |
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DerNervenarzt.00710859.eng.abstr
|
DerNervenarzt.00710859.eng.abstr
|
[
{
"id": "DerNervenarzt.00710859.eng.abstr-passage-0",
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"text": [
"The introduction of atypical antipsychotics has presented new options for the pharmacological treatment of schizophrenic patients . It is assumed that in the near future , neuroleptic medication will shift from conventional to atypical antipsychotics for an increasing number of patients . The present article addresses guidelines for the conversion from conventional to atypical neuroleptics in inpatient and outpatient settings ."
],
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0,
431
]
]
}
] |
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"id": "DerNervenarzt.00710859.eng.abstr-s3-t2",
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] |
[] |
[] |
[
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"id": "DerNervenarzt.00710859.eng.abstr-s3-r3-t4.1-t1.3",
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"id": "DerNervenarzt.00710859.eng.abstr-s3-r4-t3.1-t1.3",
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DerNervenarzt.00710876.eng.abstr
|
DerNervenarzt.00710876.eng.abstr
|
[
{
"id": "DerNervenarzt.00710876.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The assessment of body dysmorphic disorder ( BDD ) is complicated by poorly defined diagnostic criteria and a lack of valid instruments . The present pilot study examines the possible benefit of specific instruments in the discrimination of other body image disorders . Thirteen patients with BDD , 13 with disfiguring defects , and 21 with no significant impairment of appearance participated in the study . The participants were recruited from dermatological outpatients on the basis of semistructured diagnostic interviews and clinical ratings of disfigurement . Furthermore , structured interviews were conducted to determine comorbidity with depressive disorders and social phobia and to obtain a clinical rating of obsessive-compulsive symptoms using the modified version of the YBOCS for body dysmorphic disorders . In addition , the Beck depression inventory , the Social Phobia Scale , and the Social Interaction Anxiety Scale were completed . Patients with BDD differed significantly from disfigured and unimpaired patients in obsessive-compulsive symptoms , in particular obsessions , and the discrepancy between personal and clinical rating of disfigurement . However , depression and social phobia scores were only higher in comparison with unimpaired patients . Comorbidity with depressive disorders was significantly increased . Our results support the utility of the specific diagnostic instruments and indicate the particular importance of obsessive-compulsive symptoms in BDD ."
],
"offsets": [
[
0,
1495
]
]
}
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"id": "DerNervenarzt.00710876.eng.abstr-s1-t2",
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{
"id": "DerNervenarzt.00710876.eng.abstr-s1-t3",
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"BDD"
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"id": "DerNervenarzt.00710876.eng.abstr-s1-t7",
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"id": "DerNervenarzt.00710876.eng.abstr-s2-t2",
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"id": "DerNervenarzt.00710876.eng.abstr-s2-t3",
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{
"id": "DerNervenarzt.00710876.eng.abstr-s2-t5",
"type": "umlsterm",
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{
"id": "DerNervenarzt.00710876.eng.abstr-s3-t2",
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{
"id": "DerNervenarzt.00710876.eng.abstr-s3-t3",
"type": "umlsterm",
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"id": "DerNervenarzt.00710876.eng.abstr-s4-t1",
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DerNervenarzt.00710885.eng.abstr
|
DerNervenarzt.00710885.eng.abstr
|
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"text": [
"This study explored characteristic subjective experiences of schizophrenia . A questionnaire for self-assessment of disturbances in several cognitive and perceptual areas ( the Eppendorf Schizophrenia Inventory , or ESI ) was constructed and administered to first-episode schizophrenics ( SCHe , n=45), negative syndrome schizophrenics ( SCHn , n=45), remitted schizophrenics ( SCHr , n=24), depressives ( DEP , n=43), alcoholics ( ALK , n=48), obsessive-compulsive patients ( ZWA , n=46), and healthy controls ( KON , n=57). Comparisons between the SCHe , SCHn , DEP , ALK , and ZWA groups and a subsequent factor analysis revealed four schizophrenia-specific dimensions : attention and speech impairment ( AS ) , ideas of reference ( IR ) , auditory uncertainty ( AU ) , and deviant perception ( DP ) . Further analyses suggested that the AS syndrome may represent a mediating vulnerability factor while IR , AU , and DP probably are reversible episode indicators . The results may contribute to refinements in the measurement of specific prepsychotic signs , thus facilitating the development of early intervention approaches ."
],
"offsets": [
[
0,
1130
]
]
}
] |
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DerNervenarzt.00710901.eng.abstr
|
DerNervenarzt.00710901.eng.abstr
|
[
{
"id": "DerNervenarzt.00710901.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The elevated rate of schizophrenia among migrants has been explained , among others , with misdiagnosis due to symptoms ' being misinterpreted as psychotic . Previous studies have shown both higher and lower rates of psychotic symptoms of these patients when interviewed in their mother tongues , compared to being interviewed in the second language . In this study , 91 patients of Turkish origin and 50 of German origin with a paranoid-hallucinatory syndrome at admission were examined by an one interviewer each of Turkish and German origins using a standardized psychopathological instrument . In spite of comparative samples , correlation of psychopathological evaluation as well as diagnostic agreement between the two interviewers was significantly higher in the German patient group . Within the Turkish patient group , correlation was higher for those with good German language knowledge than for those with poor knowledge , yet only on a few items and without an effect on diagnostic agreement . The greatest difficulties lie in the evaluation of delusions . In spite of higher disagreement on psychopathology , the potential misdiagnoses cannot sufficiently explain the higher rate of schizophrenia among migrants ."
],
"offsets": [
[
0,
1226
]
]
}
] |
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"id": "DerNervenarzt.00710901.eng.abstr-s2-t5",
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"tongues"
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"id": "DerNervenarzt.00710901.eng.abstr-s3-t2",
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] |
[] |
[] |
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DerNervenarzt.00710906.eng.abstr
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DerNervenarzt.00710906.eng.abstr
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"For all 5.352 patients treated for schizophrenia at the Psychiatric Hospital of the University of Munich in 1981 and 1992 , detailed routine and data processing-assisted documentations were made of the psychopharmacological therapies . Nineteen of the patients committed suicide while undergoing inpatient treatment ; the control group consisted of all other patients ( n=5.333). More than 77 sociodemographic and anamnestic variables as well as 195 items from the admission summaries were taken into account while comparing the groups . Furthermore , the pharmacological data were classified according to drug groups and comparison was based on the mean frequency of prescription of each group . We analyzed the mean number of prescriptions for neuroleptics , tranquilizers , and antidepressants , which were further differentiated into sedating and nonsedating types . For frequently administered drugs , mean daily doses were also compared . Bivariate analysis of the data suggests that the suicide cases presented depressive signs , symptoms , and tendencies already present on admission more frequently than with controls ; the same applies to previously attempted suicides . Discriminating analysis showed that the variables \" feeling of loss of feelings , \" thought insertion , \" \" visible depression , \" \" free-floating anxiety , \" \" suicidal tendencies , \" and \" previously attempted suicide \" have the greatest predictive value with respect to suicide , in descending order . No differences in psychopharmacological treatment between suicides and controls were found , apart from a significantly higher percentage of antidepressive treatments and a higher mean number of antidepressant prescriptions for the suicides ."
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DerNervenarzt.00710912.eng.abstr
|
DerNervenarzt.00710912.eng.abstr
|
[
{
"id": "DerNervenarzt.00710912.eng.abstr-passage-0",
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"text": [
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],
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362
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]
}
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[] |
[] |
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DerNervenarzt.00710915.eng.abstr
|
DerNervenarzt.00710915.eng.abstr
|
[
{
"id": "DerNervenarzt.00710915.eng.abstr-passage-0",
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"text": [
"Psychiatric care for chronic schizophrenic patients has improved in recent years , but for severely ill patients , often with multiple comorbid psychiatric conditions and in great need of care , the situation remains unsatisfactory . Community-based psychiatric care is limited and psychiatric hospitals are now cutting back on inpatient care . The quality of care that chronically mentally ill patients receive at independant psychiatric nursing homes removed from population centers is undetermined , and many patients end up in asylums or homeless shelters unable to provide for their psychiatric needs . Neither a reliable way to assess the needs of these complicated patients nor a scientific basis for therapeutic intervention exists yet ."
],
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0,
745
]
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] |
DerNervenarzt.00710919.eng.abstr
|
DerNervenarzt.00710919.eng.abstr
|
[
{
"id": "DerNervenarzt.00710919.eng.abstr-passage-0",
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],
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0,
364
]
]
}
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[] |
[] |
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DerNervenarzt.60670630.eng.abstr
|
DerNervenarzt.60670630.eng.abstr
|
[
{
"id": "DerNervenarzt.60670630.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Even today acute purulent meningitis is a life-threatening disease requiring immediate diagnosis and therapy . Despite the availability of bactericidal antibiotics , the mortality has not changed within the last 20 years . A therapeutic approach interfering specifically with the pathogenesis of inflammation is necessary in order to prevent long-term neurological sequelae and death associated with bacterial meningitis . In this paper we discuss the present level of understanding of antibiotics and adjunctive therapy , especially with regard to the molecular pathophysiological events occurring during a CNS infection ."
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[
0,
623
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}
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"id": "DerNervenarzt.60670630.eng.abstr-s3-t2",
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"id": "DerNervenarzt.60670630.eng.abstr-s3-t3",
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}
] |
[] |
[] |
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DerNervenarzt.60670639.eng.abstr
|
DerNervenarzt.60670639.eng.abstr
|
[
{
"id": "DerNervenarzt.60670639.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cerebrovascular ischemia can be caused by infectious diseases which involve cerebral arteries or the heart , including infectious endocarditis , bacterial and fungal meningitis , neurosyphilis , neuroborreliosis , herpes zoster , the acquired immunodeficiency syndrome , cat scratch disease and other rare infectious diseases . Presently , there is increasing evidence that infection in general and mainly respiratory infection is a risk factor for ischemic stroke . Case reports and smaller case series reported an association of cerebrovascular ischemia and recent infection in children and younger adults . Two case control studies from Helsinki ( 54 patients under the age of 50 ) and from Heidelberg ( 197 patients aged 80 or less ) identified recent infection as an important risk factor for ischemic stroke . Febrile , bacterial and respiratory infections were most important in this respect . In the study from Heidelberg , the neurological deficit was more severe and cardioembolism was more frequent in infection-associated stroke than in stroke without preceding infection . This review summarizes the association of infectious diseases and cerebrovascular ischemia and discusses potential pathogenetic mechanisms linking both diseases ."
],
"offsets": [
[
0,
1248
]
]
}
] |
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DerNervenarzt.60670650.eng.abstr
|
DerNervenarzt.60670650.eng.abstr
|
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"id": "DerNervenarzt.60670650.eng.abstr-passage-0",
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"text": [
"CT- or MRI-guided stereotactic procedures should be a standard in a modern neurosurgical unit . Analysing 71 cases the indications and results of stereotactic neurosurgery are presented . In 53 patients stereotactic serial biopsies of different intraaxial lesions were performed , in 5 patients a spontaneous haemorrhage of the basal ganglia was removed by lysis with r-tPA . In 3 patients suffering from hydrocephalus due to diencephalic cysts a cystventricular shunt device was implanted . In 3 patients an intracerebral abscess was aspirated and drained . A stereotactic guided craniotomy and excision of small deep-seated lesions was performed in 6 cases . The accuracy of stereotactic tumour biopsies was 88.7 % in our series , in accordance to other authors . The stereotactic aspiration and drainage of an intracerebral abscess provides accurate localization and minimal cortical damage and offers the possibility of intracavitary application of antibiotics . The stereotactic internal shunt implantation seems to be an alternative approach in the treatment of diencephalic cysts due to its minimal invasiveness and low operative risk . The aspiration of basal ganglia haematomas with insertion of an external drainage allows the lysis of the haematoma with r-tPA or urokinase . With stereotactic guidance small , deep-seated intraaxial lesions can be well localized and removed ."
],
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0,
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]
]
}
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DerNervenarzt.60670667.eng.abstr
|
DerNervenarzt.60670667.eng.abstr
|
[
{
"id": "DerNervenarzt.60670667.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : For prophylaxis or therapy of lagophthalmic keratopathy ointment application or hour glass dressing is indicated . The hour glass dressing has the disadvantage of a continuous visual impairment by steaming up of the moisture chamber . The main problem for the patients is the strong subjective feeling of physical handicap . A therapeutic alternative is the gravity dependent lidloading , which is known as gold implantation in cases of irreversible lagophthalmos . Methods and patients : By lead weights of 0,8 to 2,0 g , which are fixed to the upper lid by a foil glueing on both sides ( Tesafix ) or in allergic patients by an adhesive layer , well tolerated by the skin ( Combihesive ) , the lidclosure can become restored without impairment of lidopening . In a controlled study the described method was first tested on 10 normal persons and than applied to 22 patients with lagophthalmos . Meanwhile the new method was applied to 32 further patients . Results : The \" liddynamic \" procedure is effective and well tolerated ; it is more accepted , especially during the day , because of better visual function and better cosmetics . The hour glass dressing , is still of importance in serious cases of kerathopathy during the night . Conclusion : \" lidloading \" with lead weights , which are glued by an adhesive layer to the upper lid , can be recommended as a new method in cases of reversible lagophthalmos or as a preparing step before a gold implantation ."
],
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0,
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}
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DerNervenarzt.60670672.eng.abstr
|
DerNervenarzt.60670672.eng.abstr
|
[
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"The effect of a locally applied peppermint oil preparation on tension-type headache was examined in the design of a randomized , placebo-controlled double-blind crossover study for the first time . The preparation was tested against both the reference substance acetaminophen and to the corresponding placebo . The liquid test preparation contained 10 g of peppermint oil and ethanol ( 90 % ) ad 100 ( test preparation LI 170 , Lichtwer Pharma , Berlin ) ; the placebo was a 90 % ethanol solution to which traces of peppermint oil were added for blinding purposes . The reference preparation contained 500 mg acetaminophen ; the placebo tablet was identical to the verum in size and appearance . The study included the analysis of 164 headache attacks of 41 patients of both sexes ranging between 18 and 65 years of age , suffering from tension-type headache in accordance with the IHS classification . Four headache episodes per patient were treated in a double-blind , randomized crossover design . Each headache attack was treated by the application of 2 capsules of the oral medication ( 1000 mg of acetaminophen or placebo ) and the cutaneous application of the oil preparation ( peppermint oil or placebo solution ) . The oil was spread largely across forehead and temples which was repeated after 15 and 30 minutes . Using a headache diary , the headache parameters were assessed after 15 , 30 , 45 and 60 minutes . Compared to the application of placebo , a 10 % peppermint oil in ethanol solution significantly reduced the clinical headache intensity already after 15 minutes ( p 0.01 ) . This significant clinical reduction of the pain intensity continued over the one hour observation period . Acetaminophen , too , proved to be efficient compared to placebo ( p 0.01 ) . There was no significant difference between the efficacy of 1000 mg of acetaminophen and 10 % peppermint oil in ethanol solution . Simultaneous application of 1000 mg of acetaminophen and 10 % peppermint oil in ethanol solution leads to an additive effect which remains below the significance threshold , however . The patients reported no adverse events . This controlled study showed for the first time that a 10 % peppermint oil in ethanol solution efficiently alleviates tension-type headache . Peppermint oil thus proves to be a well-tolerated and cost-effective alternative to usual therapies ."
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DerNervenarzt.60670682.eng.abstr
|
DerNervenarzt.60670682.eng.abstr
|
[
{
"id": "DerNervenarzt.60670682.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although individual extrapyramidal symptoms as a consequence of carbon monoxide intoxication have frequently been reported , typical ( complete ) Parkinson's syndrome has very rarely been documented . This report presents for the first time a case of acute Parkinson's syndrome with delayed manifestation after the initially occurring organic psychosis . A 53-year-old man with a long history of schizoaffective psychosis first developed a severe acute organic psychosis with disturbances of orientation and marked amnestic disturbances after carbon monoxide intoxication as a result of a suicide attempt . On the 21st day after intoxication , acute Parkinson's syndrome with right accentuation was recorded , with CCT identification of lesions on both sides of the basal ganglia area . Full remission of the Parkinson's syndrome was achieved with rheological treatment and l-dopa therapy ."
],
"offsets": [
[
0,
890
]
]
}
] |
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"id": "DerNervenarzt.60670682.eng.abstr-s3-t8",
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DerNervenarzt.60670686.eng.abstr
|
DerNervenarzt.60670686.eng.abstr
|
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"id": "DerNervenarzt.60670686.eng.abstr-passage-0",
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"Intramuscular injections of botulinum toxin ( BT ) induce a localized , long-lasting paresis of the target muscle that can be graded by the BT dose administered and that is free of major side effects . With this profile , BT can be used for symptomatic treatment of various disorders caused by pathological muscle hyperactivities . These disorders occur frequently in patients in institutions for neurological rehabilitation . They are difficult to treat with conventional methods , can cause major suffering and induce substantial costs for our health care system . In the present study we therefore sought to delineate the use of BT in rehabilitative neurology . Regardless of the etiology of the particular muscle hyperactivity syndrome , five main indication groups are identified : ( 1 ) improvement of function of the hyperactive muscles ; ( 2 ) relief of pain in the hyperactive muscles ; ( 3 ) improvement of patient care ; ( 4 ) avoidance of sequelae in joints , tendons , ligaments , and teeth ; ( 5 ) various special indications ."
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}
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[] |
[] |
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DerNervenarzt.60670695.eng.abstr
|
DerNervenarzt.60670695.eng.abstr
|
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{
"id": "DerNervenarzt.60670695.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We investigated the therapeutic effect of marked body weight reduction on the predominantly obstructive sleep apnea syndrome by the application of an out-patient , behaviour therapy based body weight reduction program ( Optifast-program ) in five of our obese apnea patients ( mean overweight by Broca 53,6 +/- 24,8 kg ) . Mean body weight reduction was 32,7 +/- 15,8 kg after six months . The mean apnea-index of 34,5 +/- 23,1/h prior to the weight reduction dropped to 7,8 +/- 6,1/h after therapy . The mean apnea-hypopnea-index ( so called \" respiratory disturbance index \" , RDI ) could be reduced from 45,7 +/- 26,0/h to 14,0 +/- 11,4/h. The best therapeutic effect on the sleep related respiratory parameters was seen in patients who reached their normal weight whereas the absolute weight reduction itself seems to be less important . Our results should encourage this causal therapy in appropriate patients ."
],
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[
0,
916
]
]
}
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DerNervenarzt.60670711.eng.abstr
|
DerNervenarzt.60670711.eng.abstr
|
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{
"id": "DerNervenarzt.60670711.eng.abstr-passage-0",
"type": "abstract",
"text": [
"This article reviews the chronic fatigue syndrome ( CFS ) , a disorder whose etiology is unknown . The diagnostic criteria proposed in 1994 by the CDC and the International Chronic Fatigue Syndrome Study Group are introduced . In contrast to widespread belief , there are no laboratory tests available to underpin the diagnosis of CFS ; the diagnosis is made solely on the basis of clinical criteria . In the differential diagnosis , the exclusion of other conditions that can cause chronic fatigue , such as neuropsychiatric or sleep disorders , is of critical importance . In this context , the question as to whether CFS is a clinical entity that can be differentiated from psychiatric diagnoses , such as depression , somatoform disorder , or neurasthenia , is discussed . At the moment , there is no specific therapy for CFS . Therefore , therapeutic approaches are limited to symptomatic management of the concomitant sleep disturbances , pain , or psychiatric symptoms , such as depression . Patients may benefit from cognitive behavioral therapy , as this may help then to identify and exclude factors contributing to and maintaining chronic fatigue . An integrated medical and psychological approach should be adopted , with the aim of preventing significant secondary negative results of the illness , such as interpersonal conflicts or chronic disability ."
],
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[
0,
1367
]
]
}
] |
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DerNervenarzt.60670730.eng.abstr
|
DerNervenarzt.60670730.eng.abstr
|
[
{
"id": "DerNervenarzt.60670730.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A total of 30 patients with clinically diagnosed Alzheimer's disease and 55 healthy , age-approximated controls were followed up over a 2-year period to compare the course of functional and cognitive impairment , quantitative morphological and functional brain changes . No remarkable changes were observed within the control group in any of these modalities . There were significant differences between patients and controls at the first examination : Mini-Mental State Examination ( MMSE ) , 16.1 +/- 7.3 compared with 28.7 +/- 1.4 ; left lateral ventricle 2.7 +/- 1.1 % versus 1.6 +/- 0.7 % of the total intracranial volume ; right lateral ventricle 2.7 +/- 1.4 % versus 1.4 +/- 0.4 % ; absolute delta-power 1.1 +/- 0.3 versus 0.9 +/- 0.2 µV2; and absolute theta-power 1.1 +/- 0.3 versus 0.8 +/- 0.2 µV2 ( means +/- standard deviation ) . In the patient group , scores on the Blessed dementia rating scale deteriorated from 10.6 +/- 6.1 to 17.9 +/- 9.6 ; the MMSE decreased by 8.0 +/- 3.7 ; the left lateral ventricle volume increased by 0.9 +/- 0.7 % , the right by 0.9 +/- 0.7 % of the total intracranial volume ; absolute delta-power increased by 0.2 +/- 0.4 µV2 and theta-power by 0.1 +/- 0.3 µV2. We could not confirm a relationship between age , age at onset or apolipoprotein E4 gene dose and the rate of clinical change . High initial Blessed dementia scores were correlated with more severe ventricular enlargement , and delta-theta increase during the follow-up period . High initial theta-power predicted more severe functional and cognitive deterioration . To our knowledge , this is the first longitudinal study reporting quantitative clinical , morphological and EEG-changes measured in two points in time in patients and non-demented controls ."
],
"offsets": [
[
0,
1762
]
]
}
] |
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DerNervenarzt.60670739.eng.abstr
|
DerNervenarzt.60670739.eng.abstr
|
[
{
"id": "DerNervenarzt.60670739.eng.abstr-passage-0",
"type": "abstract",
"text": [
"An increasing life expectancy leads to a higher number of persons aged 70-84 years and persons aged 85 years and older . Information concerning changes in the spectrum of psychiatric morbidity is rare . The Berlin Aging Study was based on a representative age- and gender-stratified sample ( n = 516 ) of Berlin citizens aged 70-100 years and older . In this interdisciplinary study , an intensive investigation was carried out by psychologists , sociologists , internists and psychiatrists . This report focuses on subjectively reported complaints ( Beschwerdeliste , BL ) , observed psychopathological symptomatology ( Brief Psychiatric Rating Scale , BPRS ) and psychiatric diagnoses following the criteria of DSM-III-R ( based on the Geriatric Mental State Examination , GMS-A ) . On the self-rating scale ( BL ) 10 % of all persons reported severe subjective complaints , 32 % moderate complaints . On the BPRS , 17 % showed severe psychopathological symptomatology , 75 % at least mild symptoms . Following the criteria of DSM-III-R , 23.5 % of all persons had a psychiatric disease , 4.2 % a disease of severe intensity . When the DSM-III-R diagnoses \" Not Otherwise Specified \" ( NOS ) were included 40.4 % of all subjects were diagnosed by the clinical judgement of the psychiatrists to have a psychiatric disease . The most frequent psychiatric diseases were insomnia ( 18.8 % ) , depression NOS ( 17.8 % ) and dementia ( 13.8 % ) . Dementia showed the well-known age-related increase , whereas no other incidences of psychiatric morbidity were age-related . Persons aged 70-84 years did not differ in the investigated psychiatric variables from persons aged 85 years and older , the only exception being the prevalence of dementia ."
],
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[
0,
1743
]
]
}
] |
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DerNervenarzt.60670757.eng.abstr
|
DerNervenarzt.60670757.eng.abstr
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"id": "DerNervenarzt.60670757.eng.abstr-passage-0",
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"Numerous studies conducted during the past decades indicate that the public's attitude toward the mentally ill is strongly prejudiced . Since the attitude of the general public also has an effect on community-based psychiatric care , we must ask how public opinion might be influenced . One possible approach could be through so-called key community leaders - those who are highly respected in society because of their competence in a particular area . Doctors belong to this group of people . For this reason we questioned medical students , as future key community leaders , with respect to their attitudes toward the mentally ill within the framework of their first contact with psychiatric patients during their studies . In order to make a direct comparison possible , we interviewed a sample of the Mannheim population who live in a part of the city where a variety of complementary facilities have been set up . The comparison shows that medical students do not have a more positive attitude toward the mentally ill ; in fact , in certain areas they have an even more negative attitude toward the mentally ill than the general population has . We were not able to establish what effect teaching has with respect to changing attitudes ."
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[] |
[] |
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DerNervenarzt.60670765.eng.abstr
|
DerNervenarzt.60670765.eng.abstr
|
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"id": "DerNervenarzt.60670765.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The concept of patient satisfaction has become an independent evaluation criterion in the context of quality assurance . A review of patient satisfaction surveys referring to consumer satisfaction as a relevant health care concept , mostly being conducted in the USA , identifies numerous theoretical and methodological deficiences . A consistently high level of patient satisfaction is reported , which is difficult to interpret . This requires critical analysis of what is meant by the term \" satisfaction \" , considering theoretical concepts of satisfaction taken from various research areas . The paper concludes by pointing out that the concept \" patient satisfaction \" as it is used at present should not be seen as a valid indicator for the quality of care ."
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0,
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DerNervenarzt.60670774.eng.abstr
|
DerNervenarzt.60670774.eng.abstr
|
[
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"We analyzed psychiatric and criminological data from 103 arsonists . The following criticisms of the definition of pyromania according to DSM-III-R and IDC-10 seem appropriate . First , the categoric exclusion of aggressive motives does not seem very promising , since approximately one fourth of arsonists whose firesetting is based on motives quoted in DSM-III-R may also have an aggressive motive . Second , ICD-10 gives being drunk and alcoholism as a criterion for the exclusion of pyromania . This seems untenable , since the behavior classed as pyromania is largely a product of alcohol misuse . Repeated firesetting , resulting from being fascinated by fire etc. , may be less a disturbance of impulse control but rather the manifestation of a psychoinfantilism , which , supported by alcohol abuse , extends into older age . The mean age of such arsonists is slightly above 20 years . The tendency for relapses after imprisonment seems to be low ; this tendency probably decreases spontaneously in older age . The mean age of arsonists with aggressive motives is a little below 30 years , those setting fire with suicidal motives have a mean age of 35 , deluded arsonists have a mean age of 40 years . Concrete sexual motives are relatively rare . Approximately 50 % of arsonists have a purely aggressive motive . Retaliation is a rare cause , however , since most of them do not even know the victims . One third of these persons set the fire in their own homes . Most arsonists show a personality disorder , with insecurity and narcissism predominating . Data on firesetting are to be treated with caution , since two thirds of all cases are newer resolved ; one fourth of cases concern minors , and in Central Europe arsonists with rational motives are hardly ever referred to psychiatrists ."
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DerNervenarzt.60670781.eng.abstr
|
DerNervenarzt.60670781.eng.abstr
|
[
{
"id": "DerNervenarzt.60670781.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 32-year-old man was accused of attempted rape . While urinating at the side of the road he felt an erection . He approached a 9-year-old girl who happened to be coming along and pressed his penis between her legs until ejaculation . Shortly afterwards he was arrested . He confessed , but claimed partial amnesia and had no explanation for the offence , which he normally would never have thought of . Shortly before the event a witness had seen him nearby in a poor state of orientation . Three months later in prison he suffered massive subarachnoidal hemorrhage from an aneurysm of the anterior communicating artery . The evaluation of his legal responsibility must take account of a putative psychomotor seizure at the time of the offence . With regard to the aneurysm diagnosed later , a pathogenetic connection , in terms of a preceding warning leak , might be assumed ."
],
"offsets": [
[
0,
878
]
]
}
] |
[
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},
{
"id": "DerNervenarzt.60670781.eng.abstr-s1-t2",
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},
{
"id": "DerNervenarzt.60670781.eng.abstr-s2-t1",
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"text": [
"erection"
],
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101,
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},
{
"id": "DerNervenarzt.60670781.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"penis"
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{
"id": "DerNervenarzt.60670781.eng.abstr-s3-t3",
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"id": "DerNervenarzt.60670781.eng.abstr-s7-t1",
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"id": "DerNervenarzt.60670781.eng.abstr-s7-t2",
"type": "umlsterm",
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},
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},
{
"id": "DerNervenarzt.60670781.eng.abstr-s8-t2",
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"id": "DerNervenarzt.60670781.eng.abstr-s8-t4",
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"id": "DerNervenarzt.60670781.eng.abstr-s9-t1",
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]
}
] |
[] |
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DerNervenarzt.60670785.eng.abstr
|
DerNervenarzt.60670785.eng.abstr
|
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DerNervenarzt.60670789.eng.abstr
|
DerNervenarzt.60670789.eng.abstr
|
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"id": "DerNervenarzt.60670789.eng.abstr-passage-0",
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"text": [
"We report nine case histories of patients admitted to a psychiatric hospital for severe somatic disorders . The somatic disease was either the cause of the psychiatric symptomatology , or it occurred in addition to a well-known psychiatric disorder . For general practitioners and psychiatrists it can be difficult to differentiate between symptoms due to psychiatric disorders and symptoms that indicate somatic disorders . If patients refuse the necessary diagnostic or therapeutic procedures and show behaviour that is not related to good health , there is increased risk for complications and increased morbidity ."
],
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[
0,
618
]
]
}
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DerNervenarzt.60670794.eng.abstr
|
DerNervenarzt.60670794.eng.abstr
|
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"id": "DerNervenarzt.60670794.eng.abstr-passage-0",
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"text": [
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],
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0,
387
]
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}
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DerNervenarzt.60670815.eng.abstr
|
DerNervenarzt.60670815.eng.abstr
|
[
{
"id": "DerNervenarzt.60670815.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Retrobulbar neuritis is a frequent diagnosis in patients ( age groups 20-40 years ) , who complain about acute monocular loss of vision , accompained by painful eye movements . The clinical course with recovery over about six weeks and the possibility of additional neurological dysfunction in the following years confirm the diagnosis of primarily demyelinating disease . Beside the typical retrobulbar neuritis , there is a group of vascular optic nerve disorders as well as Leber's optic neuropathy that need to be differentiated from primary demyelinating retrobulbar neuritis . Compressive optic neuropathies , unilateral chiasm disorders and infiltrative optic neuropathies will not be considered in this paper , because of their subacute presentation ."
],
"offsets": [
[
0,
759
]
]
}
] |
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DerNervenarzt.60670837.eng.abstr
|
DerNervenarzt.60670837.eng.abstr
|
[
{
"id": "DerNervenarzt.60670837.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Several historical reports focusing on the heredity of migraine , as well as recent studies on its epidemiology and molecular biology , have revealed evidence for a decisive role of genetic factors in the aetiopathogenesis of familial migraine . Indeed , family studies , segregation analyses and twin studies have shown that genetic factors play an important role in disposition towards migraine but could not explain the entire aetiopathogenesis . The influence of extragenetic factors , however , remains mostly unknown . Recent linkage analyses have provided evidence for genetic heterogeneity . A locus for Familial Hemiplegic Migraine ( FHM ) , the only known type of migraine that follows autosomal-dominant transmission , has been linked to chromosome 19p13 but genetic heterogeneity has also been shown , i . e . different types of migraine could be excluded from this locus . Further investigations should concentrate on identifying the FHM gene on chromosome 19p13, on linkage analyses with markers for different susceptibility genes , and on genomic analyses of highly informative pedigrees . This would lead to further clues to the pathogenesis underlying migraine and , thus , to therapeutic developments ."
],
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DerNervenarzt.60670846.eng.abstr
|
DerNervenarzt.60670846.eng.abstr
|
[
{
"id": "DerNervenarzt.60670846.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The exteroceptive suppression period ( ES ) of the temporalis muscle activity is a trigemino-trigeminal brain stem reflex . It will be elicited most when stimulating trigeminal sensory afferents by painful stimuli and typically leads to a biphasic interruption of voluntary muscle activity . The first phase of decreased voluntary activity is called the early exteroceptive suppression period ( ES1), the second , the late exteroceptive suppression period ( ES2). Between these two suppression periods a phase of increased muscle activity , the so-called facilitation period ( FP ) , can be seen . This phenomenon can be modulated by different stimulating parameters and usually , in healthy subjects , this normal pattern of the exteroceptive suppression can be elicited regularly . The reflex answer may occur at low non-painful stimulus intensities ; typically , however , it appears to be most pronounced with highintensity stimuli . Because of the obvious relationship between stimulus intensity , pain perception and reflex , the reflex is regarded as an antinociceptive reaction . The absence of an inhibition of motor activity can be visualized , for example , in hemimasticatory spasm or dystonic disorders . However , above all the ES nowadays attracts most attention as a tool to analyse different pain syndromes . One main advantage of this method in man is the ability to evaluate certain antinociceptive brain stem mechanisms functionally by means of a simple noninvasive technique . A large number of results have been obtained showing that chronic pain syndromes such as chronic tension-type headache and migraine cause changes within the normal ES recording pattern . Furthermore , some substances used in pain therapy , such as serotonin agonists or antagonists , acetylsalicylic acid or naloxone , may also alter the general appearance of the ES . This review will summarize different parameters that influence the ES reflex answer . Furthermore , the diagnostic value of changes in the ES for pathophysiological processes regarding pain perception and processing in certain painsyndromes will be discussed ."
],
"offsets": [
[
0,
2127
]
]
}
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DerNervenarzt.60670860.eng.abstr
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DerNervenarzt.60670860.eng.abstr
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"id": "DerNervenarzt.60670860.eng.abstr-passage-0",
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"A total of 126 patients ( 63 female , 63 male ) underwent microsurgical removal of their cerebral arteriovenous malformations ( AVMs ) by the same surgeon . The mean age at surgery was 34.7 ( 6-72 ) years . The symptoms were intracerebral hemorrhage ( 37.3 % ) , seizure disorder ( 34.9 % ) or focal neurological deficits and minor symptoms . According to the Spetzler/Martin scale , 20.6 % of the AVMs were grade I , 28.6 % grade II , 32.5 % grade III , 14.3 % grade IV and 4 % grade V. In all , 78 AVMs ( 61.9 % ) were located in functionally important brain regions . The series was split into three different groups : small AVMs under 3 cm in diameter ( n = 62/49 . 2 % ) , medium-sized AVMs ( n = 58/46 % ) and large AVMs ( n = 6/4 . 8 % ) . Seventeen patients had preoperative embolization of their AVM . All patients had postoperative angiographic control and 3- and 6-month follow-up . One patient died ( 0.8 % ) , and another one ( 0.8 % ) , in whom the AVM was incompletely resected , suffered a secondary hemorrhage . Seventeen ( 27.4 % ) of the patients with small AVMs developed transient neurological worsening postoperatively , which remained permanently significant in 3.2 % . The respective numbers for the patients with medium-sized AVMs were 48.3 % and 10.3 % and for the large AVMs 83.3 % and 33.3 % . The results of microsurgical removal of cerebral AVMs can still be considered superior to the results of stereotactic radiosurgical treatment available from the literature - even for small AVMs . This is due to immediate exclusion of the AVM under direct local control of the angioarchitecture and thereby a reduced risk of secondary hemorrhaging and a decreasing morbidity rate with increasing time after the operation . Radiosurgical treatment requires a 2-year latency period for obliteration and carries a mortality rate of up to 12.5 % and a rate of unexpected side effects of up to 20 % . This treatment should be reserved for small , deep , surgically inaccessible AVMs or used as part of a multimodality treatment regimen consisting of partial embolization , partial excision and consecutive radiation of the residual nidus in initially very large AVMs . Embolization therapy - such as radiosurgery - carries a significant risk of morbidity ( 8 % ) and a mortality rate of up to 6 % . It should only be considered for AVMs that are expected to be fully obliterated afterwards , or for primary inoperable AVMs that are to be changed into operable ones by embolization . Size reduction of otherwise operable AVMs does not justify the additional risk of embolization . Close collaboration of the specialities involved is desirable ."
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] |
DerNervenarzt.60670870.eng.abstr
|
DerNervenarzt.60670870.eng.abstr
|
[
{
"id": "DerNervenarzt.60670870.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Autosomal dominant nocturnal frontal lobe epilepsy ( ADNFLE ) is a disease entity that has only recently been discovered . Its clinical variability and the frequently missed EEG features are probably some of the reasons why this disease is often overlooked or misdiagnosed . In a large Australian pedigree , a link was found between ADNFLE and polymorphic markers on chromosome 22q13.2-q13.3. Mutation analysis identified a mis-sense mutation in the gene coding for the 4 subunit of the neuronal nicotinic acetylcholine receptor . The mutation was found in all affected family members . Thus , for the first time a likely relationship between an idiopathic epilepsy and a specific gene has been found . Additional studies will be needed to clarify the underlying pathologic mechanism . Furthermore , the hypothesis that other members of this multigene family are involved in epileptic diseases appears attractive ."
],
"offsets": [
[
0,
914
]
]
}
] |
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"id": "DerNervenarzt.60670870.eng.abstr-s3-t3",
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"id": "DerNervenarzt.60670870.eng.abstr-s3-t4",
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"id": "DerNervenarzt.60670870.eng.abstr-s3-t7",
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"id": "DerNervenarzt.60670870.eng.abstr-s3-t9",
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] |
[] |
[] |
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{
"id": "DerNervenarzt.60670870.eng.abstr-s3-r23-t2.1-t5.1",
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"id": "DerNervenarzt.60670870.eng.abstr-s7-r4-t4.1-t2.1",
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}
] |
DerNervenarzt.60670875.eng.abstr
|
DerNervenarzt.60670875.eng.abstr
|
[
{
"id": "DerNervenarzt.60670875.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 16 year old patient with the typical clinical signs of Albright's hereditary dystrophia developed series of epileptic seizures with loss of consciousness , tonic muscle contractions and bite of the tongue . After termination of the seizures there was coma without focal neurological signs . CT scan revealed diffuse brain edema . Electroencephalographic studies showed generalized slowing . In laboratory tests the only abnormalities were marked hypocalcemia ( 1.15 mmol/l ) and hyperphosphatemia . Blood parathyroid hormone ( PTH ) was elevated . PTH-Test confirmed the diagnosis of pseudohypoparathyroidism . The patient was treated with calcium and 1,25-dihydroxy-cholecalciferol. After few days the severe encephalopathy , CT and electroencephalographic changes were completely reversible . Hereditary disturbances of the parathyroid hormone metabolism are rare diseases . Hypocalcemia must be included into the differential diagnosis of seizures and brain edema to avoid invasive diagnostic and irrational treatment ."
],
"offsets": [
[
0,
1024
]
]
}
] |
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"id": "DerNervenarzt.60670875.eng.abstr-s1-t10",
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"bite"
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{
"id": "DerNervenarzt.60670875.eng.abstr-s1-t12",
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},
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"id": "DerNervenarzt.60670875.eng.abstr-s1-t13",
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"muscle contractions"
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"id": "DerNervenarzt.60670875.eng.abstr-s2-t2",
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"id": "DerNervenarzt.60670875.eng.abstr-s3-t2",
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"id": "DerNervenarzt.60670875.eng.abstr-s10-t9",
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}
] |
[] |
[] |
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DerNervenarzt.60670880.eng.abstr
|
DerNervenarzt.60670880.eng.abstr
|
[
{
"id": "DerNervenarzt.60670880.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cerebral involvement is typical for thrombotic microangiopathies like haemolytic uremic syndrome ( HUS ) and thrombotic-thrombopenic purpura ( Moschcowitz disease or TTP ) . Symptoms are irritation , restless behaviour , disorientation , disturbance of consciousness , seizures , and focal neurological deficits . The lack of typical imaging changes or pathological observations may explain the unknown pathophysiological cascade leading to the neurological symptoms . We describe the development of HUS/TTP in a 52-year-old woman after acute pneumonia caused by Diplococcus pneumoniae . The patient showed an increasing psycho-organic syndrome with disorientation , followed by severe loss of consciousness and coma . Initially , computed tomography showed slight diffuse brain oedema , which was not found in later follow-up images . Magnetic resonance imaging was normal . The TCD examination revealed general velocity increases and vasospasms ( especially MCA , ACA and PCA bilateral and BA ) . The reduction in blood flow velocities in the basal arteries was accompanied by a marked clinical improvement . The development of vasospasms may be an explanation for the neurological deficits in HUS/TTP . The origin of the vasospasms may be found in disturbed prostacyclin production , increased serotonin or platelet factor IV release , and leucocyte activation with consecutive endothelial damage ."
],
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] |
DerNervenarzt.60670883.eng.abstr
|
DerNervenarzt.60670883.eng.abstr
|
[
{
"id": "DerNervenarzt.60670883.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 46-year old patient is reported presenting with somatosensory focal seizures of either arm as the only manifestation of an otherwise clinically inapparent sarcoidosis . MRI showed signs of a granulomatous leptomeningeal affection . Histological examination of a meningeal biopsy proved the diagnosis of sarcoidosis by demonstrating noncaseating granulomas . There was no other clinical manifestation of sarcoidosis . Chest X-ray was normal and the serum level of angiotensin-converting-enzyme was only slightly elevated . The CD4/CD8 ratio in the bronchoalveolar lavage cell population , however , was clearly abnormal , supporting the role of this diagnostic tool in the diagnosis of sarcoidosis ."
],
"offsets": [
[
0,
700
]
]
}
] |
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{
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"id": "DerNervenarzt.60670883.eng.abstr-s3-t2",
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"id": "DerNervenarzt.60670883.eng.abstr-s3-t3",
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"id": "DerNervenarzt.60670883.eng.abstr-s3-t4",
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"id": "DerNervenarzt.60670883.eng.abstr-s5-t1",
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"id": "DerNervenarzt.60670883.eng.abstr-s5-t2",
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"id": "DerNervenarzt.60670883.eng.abstr-s6-t1",
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"id": "DerNervenarzt.60670883.eng.abstr-s6-t2",
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"id": "DerNervenarzt.60670883.eng.abstr-s6-t7",
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] |
[] |
[] |
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DerNervenarzt.60670891.eng.abstr
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DerNervenarzt.60670891.eng.abstr
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"In recent years , little research has been focused on alcohol hallucinosis . The psychopathology of alcohol hallucinosis ( vivid acoustic hallucinations , paranoid symptoms and fear ) resembles paranoid schizophrenia , but other organic mental disorders have to be excluded too . Prognosis is usually good , but in 10-20 % of cases alcohol hallucinosis tends to become chronic . Possible pathophysiological mechanisms involved in the development of the syndrome are changes in dopaminergic transmission or other neurotransmitter systems and neuronal membranes , elevated levels of betacarbolines and an impaired auditory system . For treatment , highly potent neuroleptics ( haloperidol ) are the drugs of first choice . In the case of alcohol abstinence the prognosis is good , but otherwise the risk of a recurrence is high ."
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DerNervenarzt.60670924.eng.abstr
|
DerNervenarzt.60670924.eng.abstr
|
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"Despite intense efforts , it has not yet been possible to clarify the etiopathogenesis of Alzheimer's dementia . There are , however , hypotheses which focus on certain aspects of this type of dementia , characterized by particular neuropathological alterations and clinical correlates . Recently , evidence has accumulated that advanced glycation endproducts ( AGEs ) could play an important role in the etiology of the Alzheimer's syndrome . AGEs are generated by an irreversible reaction through the non-enzymatic , long-term glycosylation of proteins . They are strongly resistent to proteolytic processes and induce protein crosslinking . They could thus inhibit the physiological functions of many proteins . Moreover , it is suggested that they contribute to the transformation of the soluble form of -amyloid into its unsoluble version . AGEs are also demonstrable in neurofibrillary tangles ( NFTs ) . A further mechanism by which AGEs might be pathogenic is via their induction of oxidative stress . AGEs probably exert their pathological effects not only directly because of their chemical properties , but also by indirect receptor-mediated mechanisms . Further investigation of AGE-mediated mechanisms should reveal their role in the etiopathogenesis of the Alzheimer's syndrome and , finally , lead to the development of new pharmacological strategies aimed at inhibiting protein cross-linking ."
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] |
DerNervenarzt.60670930.eng.abstr
|
DerNervenarzt.60670930.eng.abstr
|
[
{
"id": "DerNervenarzt.60670930.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Against the background of the complex relationship of alcoholism and homelessness , we investigated the question of whether homeless alcoholics and those with homes differed regarding biographical and clinical variables . Therefore , 49 of 72 ( 68.1 % ) homeless male visitors to a city kitchen in the center of Berlin , who had fulfilled the ICD-10 criteria for the alcohol-dependence syndrome , were compared with 141 outpatients of the addiction research unit of the Department of Psychiatry of the Free University of Berlin . It was found that homeless alcoholics had more psychosocial disadvantages than other alcoholics . They had been raised more frequently in families with an alcoholic father or mother and a higher number of children . The level of education and job qualification was lower in the homeless alcoholics . Early homelessness was predicted by a lack of sexual behavior ( no partnership experienced ) and a family history of alcoholism . In the interview , homeless alcoholics reported fewer symptoms of alcohol-dependence syndrome than other alcoholics ; however , the first symptoms had been experienced earlier . Alcohol-related somatic and psychological consequences were reported more frequently in alcoholics with homes , whereas social problems were more common in the homeless subjects . The results are discussed in the light of methodological limitations and other reports on the topic ."
],
"offsets": [
[
0,
1419
]
]
}
] |
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"id": "DerNervenarzt.60670930.eng.abstr-s4-t3",
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DerNervenarzt.60670935.eng.abstr
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DerNervenarzt.60670935.eng.abstr
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"The history of German psychiatry is characterized not only by innovative thought in the tradition of Kraepelin and Jaspers , but also by the \" euthanasia \" program that resulted in the killing of more than 100,000 psychiatric patients and mentally handicapped people . Exemplified by the Psychiatric Department at the University of Heidelberg , the relation between psychiatric research and the systematic killing of patients during the time of National Socialism is analysed . The first part of the paper summarizes the historical background of the general condition of German psychiatry in the 1930s and 1940s . The second part gives an outline of the biography and work of Carl Schneider ( 1891-1946 ) , head of the Psychiatric Department at Heidelberg until 1945. It can be shown that the call for intensive therapy for those patients who were to be reintegrated into society was connected with the killing of those who were considered to be beyond reach of any active therapeutic approach . This is also the context of C. Schneider's research program concerning mentally handicapped children . The historical reconstruction of research activities , drawing on the patients ' files and other documents , reveals that out of 52 children who had been examined , 20 were killed in the asylum of Eichberg in order that their brains might be examined in Heidelberg . The findings are discussed in view of the ongoing historiographical debate on the relationship between the politics of National Socialism and contemporary science ."
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DerNervenarzt.60670947.eng.abstr
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DerNervenarzt.60670947.eng.abstr
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DerNervenarzt.60670953.eng.abstr
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DerNervenarzt.60670953.eng.abstr
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"The participation of social work in inpatient psychiatric care is generally considered necessary , but there is a lack of empirical studies in this field . The analyses presented of a systematic documentation of social work interventions in 2038 cases during an 11-year period demonstrate that social workers are mostly involved in the treatment of chronic and previously treated patients . Interventions in younger patients , most of whom are suffering from psychoses , aim at rehabilitation through activity ; in elderly patients with organic or depressive disorders , the major concern is to improve posthospital care ; patients with neurotic or personality disorders comprise another group with a chronic course and a relatively poor outcome . As far as their goals are comparable , social workers and doctors agree on their objectives . Social workers usually see their own interventions as successful , but patient groups who benefit greatly can be differentiated from groups with poor outcome ."
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DerNervenarzt.60670960.eng.abstr
|
DerNervenarzt.60670960.eng.abstr
|
[
{
"id": "DerNervenarzt.60670960.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The goal of the study was a cross-cultural comparison of the parent ratings of behavior problems of children and adolescents aged 4-18 years in Germany , The Netherlands and the United States using the Child Behavior Checklist ( CBCL ) . The analyses were undertaken in a German community sample ( n = 1622 ) and a Dutch community sample ( n = 2076 ) . The results were compared with the data published by Achenbach for the national US sample . The analyses were based on the scales of the 1991 CBCL version and were performed for four age and sex groups ( 4- to 11-year-old boys/girls and 12- to 18-year-old boys/girls ) . In general , relatively minor differences could be detected between the three random samples . The range in the different samples was between -0 . 04 and 0.35 , which is in line with other cross-cultural analyses using the CBCL . As long as no representative norms for Germany are available , the American norms can serve as an orientation for German studies using the CBCL ."
],
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[
0,
999
]
]
}
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[] |
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] |
DerNervenarzt.60670975.eng.abstr
|
DerNervenarzt.60670975.eng.abstr
|
[
{
"id": "DerNervenarzt.60670975.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The unconscious patient presents an challenging emergency in the intensive care unit . Patient evaluation and treatment must occur simultaneously . After checking vital signs , deciding about cardiopulmonary resuscitation or intubation , an intravenous line must be established , blood samples collected and glucose and thiamine should be given . The physical and neurological examination should be performed in a efficient way and must consider the following eight points : best reaction to loud commands , best motor reaction to noxious stimuli , respiratory pattern , size and reactions of pupils , eye movements , corneal and blink reflex , meningismus , muscle tone and deep tendon reflexes . With this approach it is possible to formulate a working diagnosis , and the appropriate diagnostic steps can be performed ."
],
"offsets": [
[
0,
822
]
]
}
] |
[
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15
]
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},
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"id": "DerNervenarzt.60670975.eng.abstr-s1-t2",
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23
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"id": "DerNervenarzt.60670975.eng.abstr-s2-t3",
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110,
119
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}
]
},
{
"id": "DerNervenarzt.60670975.eng.abstr-s3-t1",
"type": "umlsterm",
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"signs"
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169,
174
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],
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},
{
"id": "DerNervenarzt.60670975.eng.abstr-s3-t2",
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],
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},
{
"id": "DerNervenarzt.60670975.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"intubation"
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225,
235
]
],
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"id": "DerNervenarzt.60670975.eng.abstr-s3-t4",
"type": "umlsterm",
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},
{
"id": "DerNervenarzt.60670975.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
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285
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],
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"db_id": "C0005767"
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DerNervenarzt.60670983.eng.abstr
|
DerNervenarzt.60670983.eng.abstr
|
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[] |
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DerNervenarzt.60671003.eng.abstr
|
DerNervenarzt.60671003.eng.abstr
|
[
{
"id": "DerNervenarzt.60671003.eng.abstr-passage-0",
"type": "abstract",
"text": [
"High-dose intravenous immunoglobulins ( ivIg ) are an effective therapy in chronic inflammatory demyelinating polyneuropathy ( CIDP ) and multifocal motor neuropathy ( MMN ) . In both diseases , data regarding ivIg long-term treatment are sparse . Therapy with ivIg was performed in 18 patients with CIDP or MMN . Sixteen patients responded to ivIg therapy ; they were treated for more than 6 months . Two of them had not previously shown any positive response to other immunosuppressive treatments . Response to ivIg therapy could be observed even after a long disease duration ( maximum of 19.5 years ) . All 16 therapy responders now have no or only mild clinical symptoms . Treatment could eventually be completely stopped in 6 patients ; they have now been in complete remission without therapy for a maximum of 63 months . Ten patients still receive regular ivIg infusions in different dosages . No severe side effects were observed in the whole group . IvIg therapy is an effective , safe and easily applicable treatment regimen even in the long-term course of CIDP and MMN ."
],
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}
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[] |
[] |
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DerNervenarzt.60671011.eng.abstr
|
DerNervenarzt.60671011.eng.abstr
|
[
{
"id": "DerNervenarzt.60671011.eng.abstr-passage-0",
"type": "abstract",
"text": [
"X-chromosomal recessive bulbospinal neuronopathy ( X-BNS , Kennedy's disease ) is an important differential diagnosis of amyotrophic lateral sclerosis . We present the data of ten own patients along with a review of the literature on this uncommon disease which is caused by an expanded CAG-repeat in the androgen receptor gene . This mutation probably affects the transcription regulating activity of the androgen receptor in neurons . Signs and symptoms of X-BSN can be derived from partial insensitivity for androgens and a mixed , mainly motor neuronopathy . The clinical diagnosis is based on : 1. lower motor neuron weakness of bulbar and proximal limb muscles with onset in the third to fifth decade , 2. cramps and pronounced fasciculations , particularly of facial muscles , 3. postural tremor , 4. diminished or absent sensory action potentials inspite of only minor sensory impairment , 5. gynecomastia , and 6. infertility , diabetes mellitus and hyperlipoproteinemia in a minority of cases . Unlike amyotrophic lateral sclerosis , disease progression is slow with barely shortened life expectancy , which should be stressed in patient counselling . Causal treatment is as yet unavailable but several aspects of palliative medicine should be considered ."
],
"offsets": [
[
0,
1266
]
]
}
] |
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DerNervenarzt.60671020.eng.abstr
|
DerNervenarzt.60671020.eng.abstr
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[
{
"id": "DerNervenarzt.60671020.eng.abstr-passage-0",
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"text": [
"We report three patients with severe Guillain-Barré syndrome ( GBS ) . On clinical examination , no sensory deficit was elicited . Electromyography ( EMG ) and motor nerve conduction velocity ( NCV ) studies were indicative of an axonal lesion . In two patients , we found total peripheral conduction block without volitional EMG activity . Sensory NCV and cortical median nerve evoked potentials remained normal . Sural nerve biopsy revealed unequivocal alterations of sensory nerve fibers , some in the form of primary demyelination . Therefore , these cases must bei classified as combined motor-sensory syndromes despite the clinical and electrophysiological findings . Although total denervation of the extremity muscles occurred , causing tetraparalysis , this manifestation appears to be attributable to the secondary axonal variant . In contrast to positive reports in literature , immunomodulatory treatment proved ineffective in all three cases ."
],
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0,
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]
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DerNervenarzt.60671023.eng.abstr
|
DerNervenarzt.60671023.eng.abstr
|
[
{
"id": "DerNervenarzt.60671023.eng.abstr-passage-0",
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"text": [
"We report on two patients with severe rhabdomyolysis and peripheral nerve involvement after drug intoxication . Nerve conduction studies of the paretic extremities of both patients could be performed within 12 h of the onset . Several nerves revealed evidence of conduction blocks in the paretic extremities . One of the patients who had taken heroin died and postmortem examination was performed . A drug-induced immune vasculitis could not be demonstrated . Besides striated muscle necrosis , extensive myocardial fragmentation was shown . Territorial ischemia , resulting from systemic hypotension and mechanical compression of arteries , seems to have been the cause of the myonecroses and peripheral nerve damage in the unconscious patients ."
],
"offsets": [
[
0,
747
]
]
}
] |
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[] |
[] |
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{
"id": "DerNervenarzt.60671023.eng.abstr-s7-r44-t2.1-t5.1",
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},
{
"id": "DerNervenarzt.60671023.eng.abstr-s7-r45-t1.1-t2.1",
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}
] |
DerNervenarzt.60671027.eng.abstr
|
DerNervenarzt.60671027.eng.abstr
|
[
{
"id": "DerNervenarzt.60671027.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A woman with severe stiff-man syndrome showed periodic cardiovascular dysregulation . The blood pressure changed spontaneously every 5-10 min . This rhythm was also maintained after relaxation . However , the vegetative and motoric disturbances disappeared after intrathecal application of baclofen . It is speculated that spinal GABAergic mechanisms are responsible for the tonic regulation of the cardiovascular system ."
],
"offsets": [
[
0,
422
]
]
}
] |
[
{
"id": "DerNervenarzt.60671027.eng.abstr-s1-t1",
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],
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[
2,
7
]
],
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s1-t2",
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"text": [
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],
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30,
38
]
],
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-t1",
"type": "umlsterm",
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"blood"
],
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[
90,
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]
],
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{
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},
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},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"pressure"
],
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[
96,
104
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-t3",
"type": "umlsterm",
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"blood pressure"
],
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[
90,
104
]
],
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},
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"relaxation"
],
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[
182,
192
]
],
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}
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{
"id": "DerNervenarzt.60671027.eng.abstr-s4-t1",
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"baclofen"
],
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[
290,
298
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],
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"regulation"
],
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[
381,
391
]
],
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},
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}
]
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"cardiovascular system"
],
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[
399,
420
]
],
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{
"db_name": "UMLS",
"db_id": "C0007226"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.60671027.eng.abstr-s1-r1-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerNervenarzt.60671027.eng.abstr-s5-t2",
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},
{
"id": "DerNervenarzt.60671027.eng.abstr-s1-r2-t1.1-t2.1",
"type": "associated_with",
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},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-r1-t3.2-t2.1",
"type": "measures",
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},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-r3-t2.1-t3.1",
"type": "measurement_of",
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},
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"id": "DerNervenarzt.60671027.eng.abstr-s2-r4-t3.1-t1.2",
"type": "produces",
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},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-r5-t1.1-t3.2",
"type": "location_of",
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},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-r6-t1.1-t3.1",
"type": "location_of",
"arg1_id": "DerNervenarzt.60671027.eng.abstr-s5-t1",
"arg2_id": "DerNervenarzt.60671027.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerNervenarzt.60671027.eng.abstr-s2-r8-t3.2-t1.2",
"type": "analyzes",
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"arg2_id": "DerNervenarzt.60671027.eng.abstr-s5-t1",
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}
] |
DerNervenarzt.60671030.eng.abstr
|
DerNervenarzt.60671030.eng.abstr
|
[
{
"id": "DerNervenarzt.60671030.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In two female individuals ( 37 and 47 years old ) sacral intradural arachnoid cysts caused low back pain and sciatica for several years until the correct diagnosis was established by MR imaging . Both patients had micturition disturbances ( pollakisuria ) . In both cases a sacral laminectomy was carried out and the dorsal border of the cyst wall was resected ( marsupialisation ) after evacuation of xanthochrome fluid . Neither cysts showed any communication with the subarachnoid space . Postoperatively the patients were free of complaints ; pollakisuria disappeared within 2-4 weeks ."
],
"offsets": [
[
0,
590
]
]
}
] |
[
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"female"
],
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[
7,
13
]
],
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{
"db_name": "UMLS",
"db_id": "C0086287"
},
{
"db_name": "UMLS",
"db_id": "C0015780"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
44,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"arachnoid"
],
"offsets": [
[
68,
77
]
],
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{
"db_name": "UMLS",
"db_id": "C0003707"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cysts"
],
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[
78,
83
]
],
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{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"pain"
],
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[
100,
104
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030193"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"sciatica"
],
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[
109,
117
]
],
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"db_name": "UMLS",
"db_id": "C0036396"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
154,
163
]
],
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"db_name": "UMLS",
"db_id": "C0011900"
},
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"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"imaging"
],
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[
186,
193
]
],
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{
"db_name": "UMLS",
"db_id": "C0011923"
}
]
},
{
"id": "DerNervenarzt.60671030.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"arachnoid cysts"
],
"offsets": [
[
68,
83
]
],
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DerNervenarzt.60671034.eng.abstr
|
DerNervenarzt.60671034.eng.abstr
|
[
{
"id": "DerNervenarzt.60671034.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A thoracic outlet syndrome is only rarely caused by osseous anomalies . Instead , it is a soft-tissue disease , where the C8 and T1 roots or the proximal inferior trunk of the brachial plexus are compressed by fibromuscular anomalies between the inferior cervical spine and the first rib or pleura . Thoracic outlet syndrome is a clinical diagnosis . If surgery is recommended , it should be concentrated on the fibromuscular anomalies and not on the first rib . Transaxillary removal of the first rib carries an important risk of serious complications . Among these , brachial plexus injury is the most frequent one ."
],
"offsets": [
[
0,
618
]
]
}
] |
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2,
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[] |
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DerNervenarzt.60671040.eng.abstr
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DerNervenarzt.60671040.eng.abstr
|
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{
"id": "DerNervenarzt.60671040.eng.abstr-passage-0",
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"Between 1984 and 1994 the legally required task force \" Advisory Committee to the German Federal Health Office in Matters of Approval and Review of Existing Medicines B3-Psychiatry, Neurology , Anesthesiology \" analyzed and evaluated the CNS-active compounds that until then had only possessed a fictitious registration . The evaluation was related to efficacy and safety within the indications claimed by the producers . Reviews and monographies had to be established for 445 basic compounds . One hundred positive and 30 negative monographies were published . \" Negative \" indicates that none of the claimed indications could be accepted by the committee . It is regrettable that the Federal Health Agency did not notice a considerable part of these negative evaluations until the present date . The process of the \" Aufbereitung \" was stopped abruptly by the 5th amendment of the German Drug Law in August 1994 , - a very doubtful political decision with respect to drug safety in this country ."
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[] |
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DerNervenarzt.70680011.eng.abstr
|
DerNervenarzt.70680011.eng.abstr
|
[
{
"id": "DerNervenarzt.70680011.eng.abstr-passage-0",
"type": "abstract",
"text": [
"There is a strong interrelationship between the immune system , the central nervous system and psychological processes that are suggested to play a pivotal role in the pathogenesis of psychiatric disorders . In schizophrenia and depression , activation of the immune system has been observed repeatedly . Cytokines play a key role in immune activation . They are actively transported into the CNS , but also released from activated glia cells . Cytokines activate glia cells in the CNS to produce other cytokines , and a cascade of cytokine effects may be initiated by this mechanims . During the past few years , the influence of the cytokines on dopaminergic , noradrenergic and serotonergic neurotransmission and also on the hormones of the hypothalamus-pituitary-adrenal axis has been elucidated . It suggests a pivotal role in psychological processes and psychiatric disorders . For example , in schizophrenia the IL-2 cerebrospinal fluid concentration shows a stronger relationship to the relapse probability than catecholamine metabolites . Although the hypersecretion of IL-2 in schizophrenia and of IL-6 in depression are suggested to play key roles for these disorders , a specificity of certain cytokines for certain psychiatric disorders seems unlikely . Psychomotor , sleep and sickness behavior are influenced by IL-1, disturbances of memory and attention by IL-2, but also by TNF- . From the distribution of cytokine receptors in the CNS conclusions can be drawn regarding the influence of cytokines on psychological processes . The finding that norepinephrine stimulates activated astrocytes to produce Il-6 implies that the cytokine cascade may be activated by neuronal processes under certain conditions . This can lead to a molecular biological explanation of the influences of stress on the immune system . Lastly , influences of the cytokines on blood-brain barrier disturbances and further consequences resulting from the role of the cytokine network in the CNS are discussed ."
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[] |
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] |
DerNervenarzt.70680038.eng.abstr
|
DerNervenarzt.70680038.eng.abstr
|
[
{
"id": "DerNervenarzt.70680038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Psychopathological and neurological adverse drug reactions ( ADR ) have been repeatedly reported during treatment with gyrase inhibitors ( fluorquinolones ) . Results of earlier studies indicated a high risk for ADR especially in the elderly with high dosage medication , psychiatric history and renal dysfunction . The pathophysiological mechanisms involved in the development of adverse CNS effects are not completely understood . GABA-ergic and monoaminergic mechanisms might play a major part."
],
"offsets": [
[
0,
497
]
]
}
] |
[
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},
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"id": "DerNervenarzt.70680038.eng.abstr-s3-t2",
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}
] |
[] |
[] |
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DerNervenarzt.70680048.eng.abstr
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DerNervenarzt.70680048.eng.abstr
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"From the point of view of a clinical integrative approach , psychopathological and typological clarification of the forms of anxiety that occur during major depression is undertaken . First , we examine \" pure restriction \" , expressed by anxiety accompanied by a feeling of lack of feeling . Secondly , we distinguish this from a continuous or attack-like anxiety occuring within a so-called \" destabilized restriction \" ( Janzarik ) . Finally , anxiety can be an expression of \" forced restriction \" characterized by developing tension between repression of feelings and emotions on the one hand and overloading of judgmental thought patterns on the other . We describe the appropriate structural and dynamic presuppositions of depressive anxiety syndromes and present a practical guideline for clinical therapy in its functional and personal aspects , developed as a result of our approach ."
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[] |
[] |
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DerNervenarzt.70680055.eng.abstr
|
DerNervenarzt.70680055.eng.abstr
|
[
{
"id": "DerNervenarzt.70680055.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A brief review of the literature on anger , depression , and suicidal behavior is presented . One problem of these investigations is in a lack of differentiation between the concepts of anger and anger expression . Especially , the question remains of whether depression is associated with anger turned outward or may be understood as a correlate of hostility directed to the subject . Self-destructive actions may be predicted more accurately if , in addition to severity of depression , anger and anger expression are included . In the present study of 48 older psychiatric patients the following variables were assessed : Measures for intelligence , the Self-rating Depression Scale of Zung , the questionnaire for assessing suicidality of Poeldinger , the number of attempted suicides , and the State-Trait-Anger Expression Inventory of Schwenkmezger , Hodapp and Spielberger . Anger-out and Anger Control , in contrast to depression , differentiate between patients with and without suicides attempts . The actual risk for suicide , assessed by the questionnaire for suicidality , is significantly predicted by the depression scale . The different associations of anger and depression with suicide indicators and the relevance of these results for diagnostics and prophylaxis are discussed ."
],
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0,
1296
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]
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] |
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