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DerHautarzt.90500360.eng.abstr
|
DerHautarzt.90500360.eng.abstr
|
[
{
"id": "DerHautarzt.90500360.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Papuloerythroderma of Ofuji is a rare skin disorder described primarily in Japanese patients . It occurs primarily in elderly men . The initital lesions are diffuse red papules , sparing the face , palms and soles . Later the papules coalesce into an erythroderma , with typical sparing of the skin folds and creases ( the deck chair sign ) . Pruritus is usually intense . Lymphadenopathy , peripheral blood eosinophilia and elevated IgE levels all are common . Both systemic corticosteroids and systemic PUVA therapy have been recommended . We describe a German male who fulfilled the diagnostic criteria for papuloerythroderma of Ofuji and responded well to PUVA bath therapy with both improvement in skin findings and reduction in pruritus ."
],
"offsets": [
[
0,
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]
]
}
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[
{
"id": "DerHautarzt.90500360.eng.abstr-s1-t1",
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{
"id": "DerHautarzt.90500360.eng.abstr-s1-t2",
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{
"id": "DerHautarzt.90500360.eng.abstr-s1-t4",
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"skin disorder"
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{
"id": "DerHautarzt.90500360.eng.abstr-s2-t1",
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"elderly"
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{
"id": "DerHautarzt.90500360.eng.abstr-s2-t2",
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"men"
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{
"id": "DerHautarzt.90500360.eng.abstr-s3-t1",
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"face"
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{
"id": "DerHautarzt.90500360.eng.abstr-s3-t2",
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"soles"
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"id": "DerHautarzt.90500360.eng.abstr-s4-t1",
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"sign"
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"id": "DerHautarzt.90500360.eng.abstr-s5-t1",
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"Pruritus"
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"id": "DerHautarzt.90500360.eng.abstr-s6-t1",
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"id": "DerHautarzt.90500360.eng.abstr-s6-t3",
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"id": "DerHautarzt.90500360.eng.abstr-s6-t4",
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}
] |
[] |
[] |
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DerHautarzt.90500368.eng.abstr
|
DerHautarzt.90500368.eng.abstr
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"The periungual fibromas in tuberous sclerosis are also known as Koenen tumors . Joannes Henricus Maria Koenen was born on March 10 , 1893 , in Eindhoven and died in Bois-le-Duc May 29 , 1956. From 1910 to 1918 he studied medicine at the University of Amsterdam . Then he worked as a physician at the \" Coudewater \" asylum in Rosmalen and from 1929 in the \" Voorburg \" asylum in Vught . In 1932 he published his publication concerning a family with tuberous sclerosis in which photographs of periungual fibromas are shown . His thesis in 1933 at the University in Leiden was titled \" Imbecility in children . Its Importance in pedagogic and social regard , by reason of an investigation in some communities in Noord-Brabant \" . Later he was appointed director of a state mental institution . The periungual fibromas in tuberous sclerosis were first described by Richad Kothe in Munich in 1903."
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DerHautarzt.90500398.eng.abstr
|
DerHautarzt.90500398.eng.abstr
|
[
{
"id": "DerHautarzt.90500398.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The incidence of melanoma , the most aggressive tumor of the skin , is increasing worldwide . The genetic mechanisms responsible for the initiation and progression of melanoma are poorly understood . Mutations of p16 ( CDKN2), p53, ras , neurofibromatosis type I gene ( NF-1), bcl 2 and the retinoblastoma gene have been described , but none are common . Suggesting heterogeneous mechanisms of carcinogenesis . Both familial inheritance of potential tumor suppressor genes , e.g. p16, and differences in DNA-repair capacity contribute to the individual risk for melanoma . The most important carcinogen for melanoma seems to be UV exposition whose mutagenic effects can be demonstrated by molecular analysis of detected point mutations in relevant genes . The UV-induced DNA damage generates mutations which are capable of activating proto-oncogenes or inactivating tumor suppressor genes , demonstrating the molecular link between UV exposition , DNA damage , mutations and tumor initiation and/or progression . A stage-dependent model of melanoma carcinogenesis analogous to colorectal cancer remains to be established , despite the existence of morphologically and histopathologically well defined melanoma precursor lesions in the skin ."
],
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] |
DerHautarzt.90500406.eng.abstr
|
DerHautarzt.90500406.eng.abstr
|
[
{
"id": "DerHautarzt.90500406.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The pathogenesis of allergic reactions to heparin is poorly understood . Clinically , this phenomenon is very relevant because of its increasing incidence and the resulting therapeutic difficulties . Since Plancherel's first description in 1952 , nearly 70 cases have been reported in the literature , among which female patients dominate . Heparin causes all kind of allergic reactions from type I to type IV . The most dangerous hypersensitivity reaction is heparin-induced thrombocytopenia ( HIT ) , which is a type II antibody-mediated reaction . Heparin is a mucopolysaccharide with strong protein binding potency , which seems to play an important pathogenetic role , as the heparin molecule adheres to unknown dermal or subcutaneous proteins . The heparin group contains a variety of structures with varying molecular weights . The allergen has yet to be identified . Several cross-reactions between high- and low-molecular weight heparins have been demonstrated as well as between heparin and heparinoids so that there may be more than one epitope of the heparin molecule with allergic potency . Allergic reactions after the use of alternate drugs such as heparinoids and hirudin also causes severe therapeutic difficulties ."
],
"offsets": [
[
0,
1233
]
]
}
] |
[
{
"id": "DerHautarzt.90500406.eng.abstr-s1-t1",
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"text": [
"pathogenesis"
],
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[
4,
16
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543483"
}
]
},
{
"id": "DerHautarzt.90500406.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"heparin"
],
"offsets": [
[
42,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019134"
}
]
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] |
DerHautarzt.90500412.eng.abstr
|
DerHautarzt.90500412.eng.abstr
|
[
{
"id": "DerHautarzt.90500412.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The guidelines of the International Union against Cancer are generally used to assess malignancy of squamous cell carcinoma of the skin . Beside TNM-staging , histological grading is performed . This system has been extended by a selection of histological parameters which were studied with respect to prognosis , based on a review of 184 patients with squamous cell carcinoma . An increased malignancy was found in carcinomas with the following features : clinical diameter greater than 2 cm , low degree of keratinization , high degree of cellular polymorphism , high mitotic index and high tumor thickness index ( metastases only from tumor thickness 2,4 mm and subcutaneous infiltration ) , desmoplasia and ulceration . Consideration of histological tumor parameters improved prognosis assessment . Multivariate analyses with large case series are necessary to determine ranks of the prognostic factors . Therefore , the data analysis of all centers that contribute to the carcinoma registry will make a precise difinition of high- and low-risk carcinomas possible and can thus influence therapy and follow-up procedures ."
],
"offsets": [
[
0,
1126
]
]
}
] |
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] |
DerHautarzt.90500418.eng.abstr
|
DerHautarzt.90500418.eng.abstr
|
[
{
"id": "DerHautarzt.90500418.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Six patients ( 3 children and 3 adults ) with acute exacerbated atopic eczema were treated with basic emollients in combination with chlorhexidine-soaked dressings over a period of three days using the \" wet-pyjama \" technique . Improvement of eczema was documented with the severity score \" Scoring of Atopic Dermatitis \" ( SCORAD ) ; most pronounced changes were found for the subjective parameters itch and sleep loss . Paralleling skin improvement a reduction of Staphylococcus aureus colonisation was noted . Improvement of skin changes lasted beyond the active treatment period . Wet-wrap dressings are an effective treatment modality for atopic eczema without use of corticosteroids and can be used easily on an outpatient basis when manufactured dressings are used ."
],
"offsets": [
[
0,
774
]
]
}
] |
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{
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"eczema"
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},
{
"id": "DerHautarzt.90500418.eng.abstr-s2-t1",
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},
{
"id": "DerHautarzt.90500418.eng.abstr-s2-t2",
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},
{
"id": "DerHautarzt.90500418.eng.abstr-s2-t3",
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"itch"
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},
{
"id": "DerHautarzt.90500418.eng.abstr-s2-t4",
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"sleep"
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},
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"id": "DerHautarzt.90500418.eng.abstr-s2-t5",
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"id": "DerHautarzt.90500418.eng.abstr-s3-t1",
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},
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"id": "DerHautarzt.90500418.eng.abstr-s3-t2",
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},
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"id": "DerHautarzt.90500418.eng.abstr-s3-t3",
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] |
[] |
[] |
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DerHautarzt.90500422.eng.abstr
|
DerHautarzt.90500422.eng.abstr
|
[
{
"id": "DerHautarzt.90500422.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The aim of this study was to compare the psychological stress of patients with different forms of immediate type hypersensitivity and urticaria . Moreover , the patients ' motivation for different forms of psychological treatment was assessed and an indication for psychosocial support was defined . 228 consecutive inpatients with insect venom allergies ( ins ) , food intolerance ( food ) , drug hypersensitivities ( dru ) and urticaria ( urt ) were evaluated by validated questionnaires regarding psychological strain and motivation for psychosocial treatments . Patients with food intolerance and urticaria showed significantly elevated psychological stress and higher motivation for psychosocial support as compared to those with insect venom allergies and drug intolerance . Patient education was the favourite technique for the patients ( food 78% , urt 57% , dru 24% , ins 17% ) , followed by relaxation treatment . The most important predictors for the motivation were the wish for self-responsibility , a feeling of helplessness and social limitations . If strong indication criteria are applied , psychosocial support is indicated in only small subgroups of each patient group . In spite of that , the management of allergic disease should consider the potential need for psychosocial support ."
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] |
[] |
[] |
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] |
DerHautarzt.90500428.eng.abstr
|
DerHautarzt.90500428.eng.abstr
|
[
{
"id": "DerHautarzt.90500428.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 68-year old woman presented with ulcerations on the calves that had occurred spontaneously . The very painful lesions both clinically and histologically showed the characteristics of pyoderma gangrenosum . During hospitalization she was treated with corticosteroids ( oral , i.v. , topically ) , clofazimine , cyclophosphamide , intravenous immune globulin , cyclosporine ( oral , local ) , dapsone , thalidomide and sodium cromoglycate ( topically ) without any benefit . Finally , when treated with mycophenolate mofetil ( CellCept ) ( oral ) and cyclosporine ( oral ) , her skin lesions showed continuous improvement . The topical application of thrombocytic growth factors ( cytokines ) probably accelerated the granulation . Eight weeks after initiating this treatment the lesions could be covered with split thickness skin grafts . Our observation suggests that mycophenolate mofetil , a novel immunosuppressive agent which has thus far been used almost exclusively in transplantation medicine , may be an effective therapeutic modality in combination with cyclosporine A for the treatment of pyoderma gangrenosum ."
],
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1123
]
]
}
] |
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}
] |
DerHautarzt.90500435.eng.abstr
|
DerHautarzt.90500435.eng.abstr
|
[
{
"id": "DerHautarzt.90500435.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Porokeratos of Mibelli is a rare inherited disorder of epidermal keratinization , whose pathogenesis is not fully understood . The common clinical feature is a erythematous plaque surrounded by a hyperkeratotic border . The histopathologic hallmark is a parakeratotic cornoid lamella . An unusual case of porokeratosis gigantea , a morphological variant of classical porokeratosis of Mibelli , is reported . The pathogenesis , taking in account especially the clonal hypothesis and premalignant nature of porokeratosis , is discussed ."
],
"offsets": [
[
0,
535
]
]
}
] |
[
{
"id": "DerHautarzt.90500435.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"disorder"
],
"offsets": [
[
43,
51
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"pathogenesis"
],
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[
88,
100
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543483"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"plaque"
],
"offsets": [
[
173,
179
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011389"
},
{
"db_name": "UMLS",
"db_id": "C0333463"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"porokeratosis"
],
"offsets": [
[
305,
318
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162839"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"morphological"
],
"offsets": [
[
332,
345
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543482"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"porokeratosis"
],
"offsets": [
[
367,
380
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162839"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"pathogenesis"
],
"offsets": [
[
412,
424
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543483"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"premalignant"
],
"offsets": [
[
482,
494
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032927"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"nature"
],
"offsets": [
[
495,
501
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0349590"
}
]
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"porokeratosis"
],
"offsets": [
[
505,
518
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162839"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500435.eng.abstr-s2-r1-t1.1-t1.2",
"type": "result_of",
"arg1_id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.90500435.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500435.eng.abstr-s2-r2-t1.2-t1.1",
"type": "result_of",
"arg1_id": "DerHautarzt.90500435.eng.abstr-s2-t1",
"arg2_id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-r1-t1.1-t3.1",
"type": "isa",
"arg1_id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.90500435.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-r2-t4.1-t1.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.90500435.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500435.eng.abstr-s5-r3-t1.1-t4.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.90500435.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.90500435.eng.abstr-s5-t4",
"normalized": []
}
] |
DerHautarzt.90500465.eng.abstr
|
DerHautarzt.90500465.eng.abstr
|
[
{
"id": "DerHautarzt.90500465.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pulsed laser systems such as pulsed CO2, Q-switched Er : YAG , ruby and alexandrite lasers provide good therapeutic options in therapy of scars and keloids . The use of these laser systems is compared to non-surgical and surgical methods ."
],
"offsets": [
[
0,
239
]
]
}
] |
[
{
"id": "DerHautarzt.90500465.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
7,
12
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.90500465.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"alexandrite"
],
"offsets": [
[
72,
83
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0675767"
}
]
},
{
"id": "DerHautarzt.90500465.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"lasers"
],
"offsets": [
[
84,
90
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.90500465.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"therapeutic"
],
"offsets": [
[
104,
115
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[] |
[] |
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DerHautarzt.90500470.eng.abstr
|
DerHautarzt.90500470.eng.abstr
|
[
{
"id": "DerHautarzt.90500470.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since 1977 , data of patients with malignant melanomas have been systematically documented in the tumor registry of the Tumor Center Munich . Analysis of data of 8071 patients revealed that tumor thickness has steadily declined over the years . While in 1977 the median tumor thickness was 1.45 mm , it is now 0.75 mm . This has been followed by a significant improvement in overall survival . Males and older patients tend to have thicker melanomas than females and younger patients . There has been a relative increase of melanomas of the trunk . At diagnosis , 95% of patients had local disease . Of these patients , 18.3% developed metastastes . At least two-thirds of these patients had progression at the primary tumor site or the regional lymph nodes , both of which can be assessed by clinical or ultrasound examinations . Overall survival of patients with thin melanomas is excellent and does not differ substantially from the overall survival of the general population comparable in sex and age ."
],
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[
0,
1006
]
]
}
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] |
DerHautarzt.90500479.eng.abstr
|
DerHautarzt.90500479.eng.abstr
|
[
{
"id": "DerHautarzt.90500479.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Romberg disease , also known as progressive facial hemiatrophy ( PFH ) , is an uncomman disease with progressive facial asymmetry as the major symptom . It is a atrophic process of the subcutaneous fatty tissue whose etiology is unknown . Skin , muscles and bones can be secondarily afflicted . With MRI evaluation we were able to show in 14 patients with PFH thinner subcutaneous fat , as well as flattening of the dermis in 12 of the 14. We divided the patients into three stages by the means of the MRI findings and found tendency towards concurrence between the MRI stage and the clinical stage ."
],
"offsets": [
[
0,
600
]
]
}
] |
[
{
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"disease"
],
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8,
15
]
],
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t2",
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"disease"
],
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88,
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]
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{
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t3",
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"symptom"
],
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143,
150
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],
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]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Romberg disease"
],
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[
0,
15
]
],
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{
"db_name": "UMLS",
"db_id": "C0015458"
}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"facial hemiatrophy"
],
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[
44,
62
]
],
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{
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"db_id": "C0015458"
}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t6",
"type": "umlsterm",
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"facial asymmetry"
],
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[
113,
129
]
],
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{
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"db_id": "C0015454"
}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"progressive facial hemiatrophy"
],
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[
32,
62
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s2-t1",
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"text": [
"tissue"
],
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204,
210
]
],
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]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s2-t2",
"type": "umlsterm",
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"etiology"
],
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[
217,
225
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"db_id": "C0015127"
},
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}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"fatty tissue"
],
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[
198,
210
]
],
"normalized": [
{
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"db_id": "C0001527"
}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Skin"
],
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[
239,
243
]
],
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"db_id": "C0037267"
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s3-t2",
"type": "umlsterm",
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"muscles"
],
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246,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500479.eng.abstr-s3-t3",
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"text": [
"bones"
],
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[
258,
263
]
],
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s4-t1",
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"MRI"
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],
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s4-t2",
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304,
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s4-t3",
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"patients"
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[
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},
{
"id": "DerHautarzt.90500479.eng.abstr-s4-t4",
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"fat"
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381,
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{
"id": "DerHautarzt.90500479.eng.abstr-s4-t5",
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"id": "DerHautarzt.90500479.eng.abstr-s4-t7",
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"stages"
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{
"id": "DerHautarzt.90500479.eng.abstr-s4-t9",
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}
] |
[] |
[] |
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DerHautarzt.90500483.eng.abstr
|
DerHautarzt.90500483.eng.abstr
|
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"id": "DerHautarzt.90500483.eng.abstr-passage-0",
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"text": [
"Abstract Pachyonychia congenita ( PC ) comprises a heterogeneous group of autosomal dominantly inherited conditions showing characteristic nail thickening and associated signs such as palmoplantar keratoderma , follicular keratoses , and mucosal leukokeratoses . Less frequently epidermal cysts , hairshaft abnormalities , natal teeth and laryngeal involvement may be seen . Phenotypically and genetically two major forms of PC are recognized , pachyonychia congenita Jadassohn- Lewandowsky/PC type I ( Medelian inheritance in man - MIM - 167200 ) and pachyonychia congenita Jackson-Lawler/PC type II ( MIM 167210 ) . Both conditions show nail deformities , focal palmoplantar keratoderma , and follicular hyperkeratoses . Diagnostically relevant are leukokeratoses of the oral mucosa in patients with PC type I. In contrast individuals affected with PC type II show premature dentition and multiple pilosebaceous cysts predominantely affecting the upper trunk . The latter closely resemble eruptive vellus hair cysts and steatocystoma multiplex . By mutational analysis keratin K6a and K16 gene mutations have been detected in patients with PC type I , and keratin K6b and K17 gene mutations have been shown to be the underlying genetic defect in patients with PC type II ."
],
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]
}
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] |
DerHautarzt.90500491.eng.abstr
|
DerHautarzt.90500491.eng.abstr
|
[
{
"id": "DerHautarzt.90500491.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 38-year-old female patient suddenly developed an unusual tuberous , pustular tumor on her chin . On the basis of clinical pattern , histological and microbiological investigations the diagnosis of demodicosis was established . Histological investigation revealed follicular cysts and a chronic granulomatous perifolliculitis with many of Demodex folliculorum . A large number of mites could be also identified by microscopy of smears from pustules . No cellular or humoral immunological defects , tumours nor systemic disorders were found . After oral therapy with steroids and metronidazole , the lesions improved rapidly ."
],
"offsets": [
[
0,
626
]
]
}
] |
[
{
"id": "DerHautarzt.90500491.eng.abstr-s1-t1",
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"text": [
"female"
],
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[
14,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086287"
},
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"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.90500491.eng.abstr-s1-t2",
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"patient"
],
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[
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]
],
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}
]
},
{
"id": "DerHautarzt.90500491.eng.abstr-s1-t3",
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"text": [
"tumor"
],
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79,
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]
],
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{
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"db_id": "C0027651"
}
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},
{
"id": "DerHautarzt.90500491.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"chin"
],
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[
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]
],
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"db_id": "C0008114"
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},
{
"id": "DerHautarzt.90500491.eng.abstr-s2-t1",
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"text": [
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],
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]
],
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] |
[] |
[] |
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}
] |
DerHautarzt.90500495.eng.abstr
|
DerHautarzt.90500495.eng.abstr
|
[
{
"id": "DerHautarzt.90500495.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 1990 , we first described the papular-purpuric \" gloves and socks \" syndrome ( PPGSS ) . It is characterized by an itching erythema and edema of the hands and feet together with oral mucosal lesions and fever . The skin lesions subsequently become purpuric and resolve spontaneously after a few days . In more than half of the patients , an acute parvovirus B 19 infection has been proven . In a few cases of PPGSS , other viral infections have been found , for example hepatitis B and measles . We report on a patient with PPGSS and review the literature ."
],
"offsets": [
[
0,
560
]
]
}
] |
[
{
"id": "DerHautarzt.90500495.eng.abstr-s1-t1",
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{
"id": "DerHautarzt.90500495.eng.abstr-s1-t2",
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s2-t1",
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"itching"
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s2-t2",
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126,
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{
"id": "DerHautarzt.90500495.eng.abstr-s2-t3",
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{
"id": "DerHautarzt.90500495.eng.abstr-s2-t4",
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"hands"
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s2-t5",
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"feet"
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162,
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}
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s2-t6",
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{
"id": "DerHautarzt.90500495.eng.abstr-s3-t1",
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{
"id": "DerHautarzt.90500495.eng.abstr-s4-t2",
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{
"id": "DerHautarzt.90500495.eng.abstr-s5-t2",
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{
"id": "DerHautarzt.90500495.eng.abstr-s5-t3",
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s5-t4",
"type": "umlsterm",
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{
"id": "DerHautarzt.90500495.eng.abstr-s5-t5",
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},
{
"id": "DerHautarzt.90500495.eng.abstr-s5-t6",
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"text": [
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],
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{
"id": "DerHautarzt.90500495.eng.abstr-s6-t2",
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{
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}
]
}
] |
[] |
[] |
[
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] |
DerHautarzt.90500499.eng.abstr
|
DerHautarzt.90500499.eng.abstr
|
[
{
"id": "DerHautarzt.90500499.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A patient on long term parenteral nutrition developed acrodermatitis enteropathica-like skin changes . Just as in the autosomal recessive disorder , acrodermatitis enteropathica , the lesions in our patient were caused by zinc deficiency . Replacement therapy with zinc led to rapid improvement ."
],
"offsets": [
[
0,
296
]
]
}
] |
[
{
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"patient"
],
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2,
9
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s1-t2",
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"nutrition"
],
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[
34,
43
]
],
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s1-t3",
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"acrodermatitis"
],
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[
54,
68
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s1-t4",
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"text": [
"skin"
],
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[
88,
92
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s1-t5",
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],
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23,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s2-t1",
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"disorder"
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[
138,
146
]
],
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{
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"acrodermatitis"
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},
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"patient"
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},
{
"id": "DerHautarzt.90500499.eng.abstr-s2-t4",
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"zinc"
],
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[
222,
226
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],
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{
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}
]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"deficiency"
],
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[
227,
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]
],
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{
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]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s3-t1",
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"text": [
"therapy"
],
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[
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],
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]
},
{
"id": "DerHautarzt.90500499.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"zinc"
],
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[
265,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043481"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.90500503.eng.abstr
|
DerHautarzt.90500503.eng.abstr
|
[
{
"id": "DerHautarzt.90500503.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cyclic neutropenia is a rare hematologic disorder of unknown origin . Periodic decreases in blood leukocytes with relative neutropenia and lymphocytosis are typical . These episodes appear in regular intervals of 15-35 days and last three to seven days . They are associated with physical weakness , fever , septic complications and necrosis of mucous membranes . Between the episodes , the patients are in complete clinical and laboratory remission . We report the case of a 34 year-old patient suffering from cyclic neutropenia with ulcerous lesions of the oral mucosa ."
],
"offsets": [
[
0,
572
]
]
}
] |
[
{
"id": "DerHautarzt.90500503.eng.abstr-s1-t1",
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"neutropenia"
],
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[
7,
18
]
],
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}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s1-t2",
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"text": [
"disorder"
],
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41,
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]
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}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s1-t3",
"type": "umlsterm",
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"origin"
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[
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],
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}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"hematologic disorder"
],
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[
29,
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]
],
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"db_id": "C0018939"
}
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"blood"
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},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t2",
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"text": [
"leukocytes"
],
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98,
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]
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t3",
"type": "umlsterm",
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"relative"
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t4",
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"neutropenia"
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}
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t5",
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"text": [
"lymphocytosis"
],
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139,
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]
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{
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"db_id": "C0024282"
}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"in blood"
],
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89,
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}
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"blood leukocytes"
],
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92,
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]
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{
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]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t1",
"type": "umlsterm",
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"weakness"
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],
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"db_id": "C0086525"
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}
]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"fever"
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300,
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]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t3",
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],
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}
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"necrosis"
],
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333,
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]
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]
},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t5",
"type": "umlsterm",
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],
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t6",
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"text": [
"membranes"
],
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s4-t7",
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},
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"id": "DerHautarzt.90500503.eng.abstr-s5-t1",
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"patients"
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s5-t2",
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{
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},
{
"id": "DerHautarzt.90500503.eng.abstr-s6-t2",
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{
"id": "DerHautarzt.90500503.eng.abstr-s6-t3",
"type": "umlsterm",
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"mucosa"
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{
"id": "DerHautarzt.90500503.eng.abstr-s6-t4",
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"text": [
"oral mucosa"
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{
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}
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}
] |
[] |
[] |
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{
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] |
DerHautarzt.90500556.eng.abstr
|
DerHautarzt.90500556.eng.abstr
|
[
{
"id": "DerHautarzt.90500556.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The serin protease tryptase ( ECNr . 3.4.21.59 ) , which is almost exclusively expressed in mast cells , is released by mast cell degranulation in an enzymatically active form together with other mediators , e.g. histamine , into the extracellular space and the circulation . The capability of the enzyme to directly stimulate several cell types as well as to cleave polypeptide hormones and to activate pro-enzymes suggests a role for tryptase in inflammatory and tissue-remodeling processes . Therefore , in the skin , a role of tryptase is suggested not only in mastocytosis and immediate type hypersensitivity reactions , but also in other inflammatory diseases , degenerative or neoplastic conditions as well as in wound healing , where an accumulation and/or activation of mast cells is found . Extracellular tryptase may be superior to histamine as a parameter for the onset and course of immediate type reactions and as an indicator for the activation of mast cells in other conditions . Its absence during histamine-liberating reactions may suggest basophil activation . In addition , tryptase has been shown to be a sensitive and specific marker for the localization of mast cells in tissues ."
],
"offsets": [
[
0,
1203
]
]
}
] |
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{
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},
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"id": "DerHautarzt.90500556.eng.abstr-s1-t3",
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"tryptase"
],
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19,
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"id": "DerHautarzt.90500556.eng.abstr-s2-t9",
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"id": "DerHautarzt.90500556.eng.abstr-s2-t10",
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"extracellular space"
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] |
DerHautarzt.90500562.eng.abstr
|
DerHautarzt.90500562.eng.abstr
|
[
{
"id": "DerHautarzt.90500562.eng.abstr-passage-0",
"type": "abstract",
"text": [
"As a premalignant condition , actinic cheilitis requires therapy , and multiple treatment modalities have been described . Although frequently reported in Angloamerican literature , CO2 laser vaporization for the treatment of actinic cheilitis is scarcely mentioned in German journals . We report 19 cases of CO2 laser treatment of actinic cheilitis . In only one case , the ablation proved to be too superficial after the first treatment . Except in this case we did not see any recurrences and only one case with minor scarring within a median follow up period of 16 months . In comparison with other treatment modalities , we consider the CO2 laser ablation to be a safe and cost-saving method with excellent cosmetic results ."
],
"offsets": [
[
0,
730
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.90500566.eng.abstr
|
DerHautarzt.90500566.eng.abstr
|
[
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]
}
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] |
[] |
[] |
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] |
DerHautarzt.90500572.eng.abstr
|
DerHautarzt.90500572.eng.abstr
|
[
{
"id": "DerHautarzt.90500572.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The 20-year radiotherapy ( RT ) experience in patients with locally advanced , recurrent or metastatic malignant melanoma ( MM ) is analyzed with respect to different endpoints and prognostic factors . From 1977 to 1995 , 2917 consecutive patients were entered in our MM registry . RT was indicated in 121 patients ( 56 females , 65 males ) for palliation in advanced MM stages . The histology of the primary lesion was nodular in 51 , superficial spreading in 35 , acral-lentiginous in 8 and lentigo maligna in 4 patients ) ; 22 were missing or could not be reclassified . Eleven patients had primary or recurrent lesions which were ineligible for surgery or had residual disease ( R2) after resection of a primary or recurrent lesion ( UICC IIB ) ; 57 patients had lymph node ( 33 ) or in-transit metastases ( 24 ) ( UICC III ) , 53 had distant organ metastases ( 7 M1a; 46 M1b) ( UICC IV ) . Time from first diagnosis to on-study RT averaged 19 ( median : 18 ; range : 3-186 ) months . In most cases conventional RT was applied ( 2-6 Gy single fractions ) up to a mean total RT dose of 45 ( median : 48 ; range : 20-66 ) Gy . At 3 months follow-up ( FU ) , complete response ( CR ) was achieved in 7 ( 64% ) and overall response ( CR+PR ) in all ( 100% ) UICC IIB patients , in 25 ( 44% ) /44 ( 77% ) of 57 UICC III patients , and in 9 ( 17% ) /26 ( 49% ) of 53 UICC IV patients . Progression during RT occurred in 25 ( 21% ) patients . Patients with CR survived longer ( median : 40 months ) than those without CR ( median : 10 months ) ( p 0.01 ) . At last FU , 26 patients were alive : 6 ( 55% ) UICC IIB , 17 ( 30% ) UICC III , and 3 ( 6% ) UICC IV patients ( p 0.01 ) . In univariate analysis following favorable prognostic factors for CR and long-term survival were identified : low UICC stage ( p 0.001 ) , primary site head and neck and total dose > 40 Gy ( all p 0.05 ) ; age , gender and histology had no impact . In multivariate analysis , UICC stage was the only independent favorable prognostic factor for CR and long-term survival ( p 0.001 ) . External RT provides effective palliation and long-term local tumor control in advanced UICC stages . UICC staging is a good predictor for initial and long-term response in metastatic MM . Prospective randomized trials using RT with or without adjuvant therapy for advanced MM are justified ."
],
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}
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] |
DerHautarzt.90500580.eng.abstr
|
DerHautarzt.90500580.eng.abstr
|
[
{
"id": "DerHautarzt.90500580.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 34 year-old pregnant woman presented with reticulate pigmentation of the flexures , the dorsum of the hands and the genitoperianal region . She was in good health and her family history was unremarkable . Histologic examination of the hyperpigmented patches revealed pigmented filiform downgrowths of the interfollicular epidermis and follicular infundibula , as well as small epithelial cysts . Upon immunohistochemical and ultrastructural studies , the number of melanocytes appeared normal . The elongated dendritic processes of the melanocytes contained many mature melanosomes . In the adjacent keratinocytes large melanosomes did not aggregate into complexes . The diagnosis of localized reticulate pigmentary disorder was established . The knowledge of the broad clinical spectrum of localized reticulate hyperpigmentations with its favorable prognosis is of practical importance . Genital or flexural pigmented lesions have to be differentiated from melanosis of the vulva or acanthosis nigricans . The presented case gives further evidence that many of the proposed entities characterized clinically by reticulate pigmented macules and hyperkeratotic follicular lesions are different phenotypic expressions of the same autosomal dominant genodermatosis ."
],
"offsets": [
[
0,
1265
]
]
}
] |
[
{
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"woman"
],
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23,
28
]
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"pigmentation"
],
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55,
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]
],
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"db_id": "C0031911"
}
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},
{
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"dorsum"
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},
{
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"type": "umlsterm",
"text": [
"hands"
],
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104,
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]
],
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}
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},
{
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"text": [
"pregnant woman"
],
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14,
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]
],
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"db_id": "C0033011"
}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s2-t1",
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"health"
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}
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"family"
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}
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},
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"id": "DerHautarzt.90500580.eng.abstr-s2-t3",
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"text": [
"history"
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180,
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},
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-t1",
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"Histologic"
],
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207,
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],
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"epidermis"
],
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323,
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]
],
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"db_id": "C0014520"
}
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"infundibula"
],
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348,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-t4",
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"cysts"
],
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},
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"melanocytes"
],
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]
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"melanocytes"
],
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538,
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"id": "DerHautarzt.90500580.eng.abstr-s5-t2",
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"melanosomes"
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"id": "DerHautarzt.90500580.eng.abstr-s6-t1",
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"keratinocytes"
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{
"id": "DerHautarzt.90500580.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"melanosomes"
],
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]
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"diagnosis"
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"knowledge"
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"id": "DerHautarzt.90500580.eng.abstr-s8-t2",
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"prognosis"
],
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s9-t1",
"type": "umlsterm",
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"melanosis"
],
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]
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s9-t2",
"type": "umlsterm",
"text": [
"vulva"
],
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}
]
},
{
"id": "DerHautarzt.90500580.eng.abstr-s9-t3",
"type": "umlsterm",
"text": [
"acanthosis nigricans"
],
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986,
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]
],
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"db_id": "C0000889"
}
]
}
] |
[] |
[] |
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},
{
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},
{
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"type": "adjacent_to",
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},
{
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"arg2_id": "DerHautarzt.90500580.eng.abstr-s9-t3",
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s2-r2-t3.2-t3.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.90500580.eng.abstr-s9-t3",
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},
{
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s2-r4-t2.1-t3.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.90500580.eng.abstr-s9-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-r1-t3.1-t1.1",
"type": "surrounds",
"arg1_id": "DerHautarzt.90500580.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.90500580.eng.abstr-s9-t1",
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},
{
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s3-r3-t1.1-t3.1",
"type": "developmental_form_of",
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},
{
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"type": "produces",
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s5-r1-t2.1-t1.1",
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{
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},
{
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{
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},
{
"id": "DerHautarzt.90500580.eng.abstr-s9-r3-t2.2-t1.1",
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},
{
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"arg2_id": "DerHautarzt.90500580.eng.abstr-s9-t1",
"normalized": []
}
] |
DerHautarzt.90500586.eng.abstr
|
DerHautarzt.90500586.eng.abstr
|
[
{
"id": "DerHautarzt.90500586.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Focal acral hyperkeratosis is a disorder characterized by hyperkeratotic papules along the border of the hands and feet . Focal acral hyperkeratosis and several marginal punctate keratodermas closely resemble acrokeratoelastoidosis of Costa . The question if there is a difference between acrokeratoelastoidosis of Costa and focal acral hyperkeratosis or if they are variants of the same entity are discussed . We report a case showing focal acral hyperkeratosis , review the clinical and histological features of related conditions and present a modified concept of marginal papular acrokeratodermas ."
],
"offsets": [
[
0,
602
]
]
}
] |
[
{
"id": "DerHautarzt.90500586.eng.abstr-s1-t1",
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"text": [
"hyperkeratosis"
],
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[
12,
26
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"disorder"
],
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[
32,
40
]
],
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{
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"hands"
],
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[
105,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018563"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"feet"
],
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[
115,
119
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016504"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
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[
134,
148
]
],
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{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
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[
337,
351
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.90500586.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
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[
448,
462
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
}
] |
[] |
[] |
[
{
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"type": "adjacent_to",
"arg1_id": "DerHautarzt.90500586.eng.abstr-s1-t3",
"arg2_id": "DerHautarzt.90500586.eng.abstr-s1-t4",
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},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-r2-t4.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.90500586.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-r3-t3.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500586.eng.abstr-s1-t3",
"arg2_id": "DerHautarzt.90500586.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-r4-t4.1-t3.1",
"type": "adjacent_to",
"arg1_id": "DerHautarzt.90500586.eng.abstr-s1-t4",
"arg2_id": "DerHautarzt.90500586.eng.abstr-s1-t3",
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},
{
"id": "DerHautarzt.90500586.eng.abstr-s1-r5-t1.1-t3.1",
"type": "part_of",
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}
] |
DerHautarzt.90500590.eng.abstr
|
DerHautarzt.90500590.eng.abstr
|
[
{
"id": "DerHautarzt.90500590.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The case of a 30 year old man with acatalasemia is presented . The congenital disorder is charaterized by a lack or major reduction of catalase , an enzyme that catalyzes the decomposition of hydrogen peroxide to oxygen and water . The defect is inherited in an autosomal recessive fashion . Occasionally the defect manifests as progressive oral gangrene or Takahara's , disease ."
],
"offsets": [
[
0,
380
]
]
}
] |
[
{
"id": "DerHautarzt.90500590.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
22,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"man"
],
"offsets": [
[
26,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025266"
},
{
"db_name": "UMLS",
"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"acatalasemia"
],
"offsets": [
[
35,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0268419"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"congenital"
],
"offsets": [
[
67,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009678"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"disorder"
],
"offsets": [
[
78,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"catalase"
],
"offsets": [
[
135,
143
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007367"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"enzyme"
],
"offsets": [
[
149,
155
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014442"
},
{
"db_name": "UMLS",
"db_id": "C0014445"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"hydrogen"
],
"offsets": [
[
192,
200
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020275"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"peroxide"
],
"offsets": [
[
201,
209
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031180"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"oxygen"
],
"offsets": [
[
213,
219
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030054"
},
{
"db_name": "UMLS",
"db_id": "C0184633"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"water"
],
"offsets": [
[
224,
229
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020311"
},
{
"db_name": "UMLS",
"db_id": "C0043047"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"congenital disorder"
],
"offsets": [
[
67,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242354"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"hydrogen peroxide"
],
"offsets": [
[
192,
209
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020281"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"defect"
],
"offsets": [
[
236,
242
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"defect"
],
"offsets": [
[
309,
315
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"gangrene"
],
"offsets": [
[
346,
354
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017086"
}
]
},
{
"id": "DerHautarzt.90500590.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
371,
378
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
}
] |
[] |
[] |
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DerHautarzt.90500593.eng.abstr
|
DerHautarzt.90500593.eng.abstr
|
[
{
"id": "DerHautarzt.90500593.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Acanthosis nigricans is a hyperkeratotic mucocutaneous eruption of heterogenous etiology which is characterized by hyperpigmentation , velvety cutaneous thickening , intensified skin markings and development of verrucous excrescences typically involving the intertriginous areas . Malignant acanthosis nigricans is most often associated with an abdominal adenocarcinoma frequently unresectable at the time of diagnosis . We report on the rare association of acanthosis nigricans with a transitional cell carcinoma of the urinary bladder . Symptomatic treatment with topical calcipotriol significantly reduced the hyperkeratotic and papillomatous skin changes ."
],
"offsets": [
[
0,
660
]
]
}
] |
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"id": "DerHautarzt.90500593.eng.abstr-s1-t2",
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"id": "DerHautarzt.90500593.eng.abstr-s3-t4",
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[] |
[] |
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DerHautarzt.90500621.eng.abstr
|
DerHautarzt.90500621.eng.abstr
|
[
{
"id": "DerHautarzt.90500621.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Different pest arthropods and dermatophytes occurring primarily in farm animals may be transmissible to man and produce human dermatoses . The movement and cutaneous penetration habits of external parasites often cause crusted papules , severe itching and dermatitis or may damage their hosts by blood-sucking or by sensitizing them to their saliva . Furthermore different dermatophytes should be considered a possible cause of human skin lesions . Farm animals ( cattle , pig , poultry , and rabbit ) can transmit external parasites ( ticks : Ixodes ricinus , Argas reflexus ; fleas : Ceratophyllus gallinae , Spilopsyllus cuniculi , and mites : Sarcoptes scabiei var . bovis , Sarcoptes scabiei var . suis , Dermanyssus gallinae , Cheyletiella parasitovorax ) , and dermatophytes ( Trichophyton sp . , and Microsporum sp . ) . People who have close contact to infested farm animals are more often exposed to epizoonotic infections . Certain professions , such as farmers , and veterinarians , are especially vulnerable ."
],
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0,
1022
]
]
}
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] |
DerHautarzt.90500643.eng.abstr
|
DerHautarzt.90500643.eng.abstr
|
[
{
"id": "DerHautarzt.90500643.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We examined the prevalence of HIV-associated cutaneous disorders as well as the frequency and efficiency of UV-radiation in HIV-infected patients by evaluating the clinical records of 1310 patients seen between and 1994 and 1996. 41 patients were treated with UVB-radiation and 4 patients with UVA1-radiation, while three patients received PUVA-therapy . UV-radiation proved to be efficient and safe in the treatment of pruritic papular eruption , atopic dermatitis and psoriasis . Although some in vitro studies and studies with transgenic mice have suggested a negative impact of UV radiation on the immunosystem of HIV-positive patients , no progression of the HIV infection due to phototherapy has been proven ."
],
"offsets": [
[
0,
715
]
]
}
] |
[
{
"id": "DerHautarzt.90500643.eng.abstr-s1-t1",
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"prevalence"
],
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16,
26
]
],
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}
]
},
{
"id": "DerHautarzt.90500643.eng.abstr-s1-t2",
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"id": "DerHautarzt.90500643.eng.abstr-s1-t3",
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"frequency"
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]
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{
"id": "DerHautarzt.90500643.eng.abstr-s1-t4",
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}
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"records"
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280,
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{
"id": "DerHautarzt.90500643.eng.abstr-s1-t10",
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"patients"
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322,
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}
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},
{
"id": "DerHautarzt.90500643.eng.abstr-s1-t11",
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"records of"
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173,
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},
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"id": "DerHautarzt.90500643.eng.abstr-s2-t1",
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"treatment"
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}
]
},
{
"id": "DerHautarzt.90500643.eng.abstr-s2-t2",
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"dermatitis"
],
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},
{
"id": "DerHautarzt.90500643.eng.abstr-s2-t3",
"type": "umlsterm",
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],
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}
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},
{
"id": "DerHautarzt.90500643.eng.abstr-s2-t4",
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{
"id": "DerHautarzt.90500643.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.90500643.eng.abstr-s3-t2",
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"id": "DerHautarzt.90500643.eng.abstr-s3-t4",
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"id": "DerHautarzt.90500643.eng.abstr-s3-t6",
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{
"id": "DerHautarzt.90500643.eng.abstr-s3-t8",
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"id": "DerHautarzt.90500643.eng.abstr-s3-t9",
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}
] |
[] |
[] |
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DerHautarzt.90500649.eng.abstr
|
DerHautarzt.90500649.eng.abstr
|
[
{
"id": "DerHautarzt.90500649.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a controlled prospective study we compared the efficacy of combined salt water bath and UVA/B phototherapy to a UVA/B mono-phototherapy in patients with subacute atopic dermatitis ( AD ) . The patients in the balneophototherapy group ( n=16) were treated with baths containing 3-5% of the synthetic salt Psori-sal , followed immediately by UVA/B irradiation , while the other treatment arm ( n=12) received UVA/B phototherapy alone . After 20 treatments the balneophototherapy group showed a statistically significant ( p =0 . 0015 ) reduction of the SCORAD score from 69.5 before to 36.8 after therapy . No statistically significant reduction in the SCORAD score could be observed in the UVA/B phototherapy group ( 50.6 before to 44.3 after therapy ) . The cumulative UVB dose was significantly lower in the balneophototherapy group ( 0.9 J/cm2) as compared to the UVA/B monotherapy group ( 2.0 J/cm2). Balneophototherapy was well tolerated by patients with atopic dermatitis and no side effects were observed . We conclude that balneophototherapy expands the therapeutic options for patients with subacute atopic dermatitis ."
],
"offsets": [
[
0,
1130
]
]
}
] |
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{
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},
{
"id": "DerHautarzt.90500649.eng.abstr-s1-t3",
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"bath"
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] |
[] |
[] |
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DerHautarzt.90500654.eng.abstr
|
DerHautarzt.90500654.eng.abstr
|
[
{
"id": "DerHautarzt.90500654.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Interferon-alpha ( IFN- ) is of high interest in the adjuvant treatment of malignant melanoma . During long term treatment , psychiatric side effects play an important role and not infrequently lead to reduction or discontinuation of therapy . Most common are sleeping disturbance , agitation , weariness , sleepiness , irritability , social withdrawal and depression , which most often develop during the first three months of the therapy . Also more severe side effects may occur , like delirium , organic depression , psychotic episodes and organic personality change , which in some patients may even lead to suicidal thoughts or suicide attempts , which is illustrated in two case reports . Therapeutic intervention depend to the severity of side effects . Moderate depressive syndromes may successfully be treated by antidepressive drugs like serotonine reuptake inhibitors ( SSRI ) , which may even allow continuation of IFN- therapy . In patients with severe depression or organic personality changes with increased risk of suicide , immideate discontinuation of IFN- therapy is mandatory and treatment in a psychiatric hospital must be considered ."
],
"offsets": [
[
0,
1157
]
]
}
] |
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DerHautarzt.90500659.eng.abstr
|
DerHautarzt.90500659.eng.abstr
|
[
{
"id": "DerHautarzt.90500659.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 64 year old female patient was diagnosed with scleroderma and has been bed-ridden for 25 years . She wears no clothing whatsoever on the grounds of an intolerance to textiles , and has spent the last eight years uninterruptedly in bed in a construction of kitchen paper towels and rubber bed sheets . A somatic disease has been be ruled out and cenesthesic schizophrenia diagnosed . As differential diagnoses , somatization , somatiform disorders and hypochondria were considered . The patient refused any psychiatric treatment ."
],
"offsets": [
[
0,
531
]
]
}
] |
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[] |
[] |
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DerHautarzt.90500665.eng.abstr
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DerHautarzt.90500665.eng.abstr
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"id": "DerHautarzt.90500665.eng.abstr-passage-0",
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"We report the case of a a 60 year-old worker in the pharmaceutical industry who suffered from recurring contact dermatitis . Initially the contact dermatitis was limited to the hands ; later on it became generalized . The patient had been working on a drug filling line in a pharmaceutical plant for more than 20 years . Eight years after starting this job he had developed allergic hand dermatitis to 2,6-diaminopyridine ( patch test positive ) ; this healed upon cessation of exposure . Ten years later he again developed hand dermatitis which progressed to generalized dermatitis and conjunctivitis . Under systemic and local therapy with corticosteroids and cessation of work , it healed nearly completly . Four months after returning to work , the patient experienced a first episode of severe asthma and generalized dermatitis with conjunctivitis following exposure to hydroxychloroquine the day before . The asthma and dermatitis improved after systemic corticosteroid therapy and stopping work . His condition continued to fluctuate , when though the patient was transferred at work and now wore rubber gloves . Eight months later he again developed a generalized dermatitis . Patch testing revealed delayed-type sensitizations to hydroxychloroquine ( tested in concentrations of 0.1% , 0.5% , 1% and 2% ) . Equivalent tests in five healthy volunteers were negative . The patch test reactions were pustular , while a biopsy was interpreted as a multiform contact dermatitis reaction . Bronchial exposure with hydroxychloroquine dust produced a delayed bronchial obstruction over the next 20 hours , which progressed to fever and generalized erythema ( hematogenous contact dermatitis ) . After removing exposure to 2,6-diaminopyridine and hydroxychloroquine , the patient went on to develop a contact dermatitis to latex ( patch test positive ) . However , skin prick tests with latex and patch tests with rubber additiva were negative . Hydroxychloroquine is well known to cause drug reactions . To our knowledge , contact dermatitis to this substance has not yet been reported . It is noteworthy that the patch test reactions were pustular and of multiform morphology and that bronchial exposure to the allergen resulted in asthma and a generalized drug reaction . Pathogenetically the asthmatic reaction seems to be on a delayed-type mechanism as is also seen with ampicillin , cobalt and nickel induced asthma ."
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] |
DerHautarzt.90500670.eng.abstr
|
DerHautarzt.90500670.eng.abstr
|
[
{
"id": "DerHautarzt.90500670.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Gastrointestinal side effects and the developpement of toxic liver fibrosis are well-known side effects of low dose methotrexate therapy . A female patient receiving a long term low dose methotrexate therapy for a seronegative chronic polyarthritis developed an ulcerative somatitis , as clinical clue to an inadvertently given methotrexate overdose . A summary of other side effects of methotrexate and of oral side effects of other cytostatic agents and immonosuppressive drugs is given ."
],
"offsets": [
[
0,
490
]
]
}
] |
[
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t1",
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"toxic"
],
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[
55,
60
]
],
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{
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"db_id": "C0600688"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"liver"
],
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[
61,
66
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0345904"
},
{
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"db_id": "C0023884"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"fibrosis"
],
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[
67,
75
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016059"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"methotrexate"
],
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[
116,
128
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025646"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"therapy"
],
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[
129,
136
]
],
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{
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},
{
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"side effects"
],
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[
17,
29
]
],
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{
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"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"liver fibrosis"
],
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[
61,
75
]
],
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"db_id": "C0239946"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"side effects"
],
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[
91,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"female"
],
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[
141,
147
]
],
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{
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"db_id": "C0086287"
},
{
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
148,
155
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"methotrexate"
],
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[
187,
199
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"therapy"
],
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]
],
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{
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{
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t5",
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"text": [
"polyarthritis"
],
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235,
248
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],
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"db_id": "C0162323"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t6",
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"text": [
"methotrexate"
],
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328,
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],
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{
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"overdose"
],
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[
341,
349
]
],
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{
"db_name": "UMLS",
"db_id": "C0029944"
}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"methotrexate"
],
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],
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}
]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"cytostatic"
],
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434,
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{
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]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"drugs"
],
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[
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],
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{
"db_name": "UMLS",
"db_id": "C0013227"
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]
},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"side effects"
],
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},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t5",
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"side effects"
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},
{
"id": "DerHautarzt.90500670.eng.abstr-s3-t6",
"type": "umlsterm",
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"cytostatic agents"
],
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451
]
],
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{
"db_name": "UMLS",
"db_id": "C0010858"
}
]
}
] |
[] |
[] |
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{
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] |
DerHautarzt.90500674.eng.abstr
|
DerHautarzt.90500674.eng.abstr
|
[
{
"id": "DerHautarzt.90500674.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Wax has been used for illustration purposes back to antiquity . Since the renaissance period human anatomy and different diseases have often been depicted in wax . During the last century the art of moulage preparation evolved to three-dimensional , realistic representations of diseased parts of the human body . Its heyday and wide spread distribution paralleled the growing independence of dermatology . Apart from few exceptions , most mouleurs did not permit access to their technique either to successors or the public . Just like other European hospitals , the Department of Dermatology at Kiel University houses a comprehensive collection of moulages dating back to a century . The 455 objects left today were collected by Professor Viktor Felix Karl Klingmueller ( 1870-1942 ) who was head of the department from 1906 to 1937. The mouleur Alfons Kroener from Breslau who died 1937 supplied most ( 354 ) of the wax models . Highly esteemed at his time , Kroener was quite secretive about his art of moulagig . 35 of his moulages bear the abbrevation \" DRP \" standing for Deutsches Reichspatent ( German patent ) ; Kroener was granted a patent in 1902. In his patent application both wax mixtures and technical procedure of moulaging are described in great detail . Kroener , similarly to Jules Baretta ( Paris ) , coloured his moulages at the back of the wax layers . Applying for a patent demonstrates his effort to meet increasing commercial pressure among suppliers of teaching aids at that time . Knowledge of individual technical procedures is essential for medical history as well as proper restauration of moulages as they continually deteriorate with time . Because of their three-dimensional and realistic disease representations , moulages still compare well to modern media used today . Consequently , the \" dying of moulages \" concerning the wax objects themselves as well as public or medical interest has to be stopped to preserve moulages for future generations ."
],
"offsets": [
[
0,
1986
]
]
}
] |
[
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},
{
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},
{
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},
{
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s9-r3-t1.1-t5.2",
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},
{
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},
{
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r3-t3.1-t4.1",
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r4-t3.1-t2.1",
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r5-t6.1-t2.1",
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},
{
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},
{
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},
{
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"normalized": []
},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r9-t4.1-t5.2",
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r10-t2.1-t6.1",
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r11-t4.1-t2.1",
"type": "affects",
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"normalized": []
},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r12-t4.2-t2.1",
"type": "affects",
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"normalized": []
},
{
"id": "DerHautarzt.90500674.eng.abstr-s11-r13-t4.2-t5.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.90500674.eng.abstr-s11-t5",
"normalized": []
},
{
"id": "DerHautarzt.90500674.eng.abstr-s12-r1-t3.2-t2.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.90500674.eng.abstr-s12-t3",
"arg2_id": "DerHautarzt.90500674.eng.abstr-s14-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500674.eng.abstr-s13-r1-t1.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.90500674.eng.abstr-s14-t1",
"arg2_id": "DerHautarzt.90500674.eng.abstr-s14-t2",
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},
{
"id": "DerHautarzt.90500674.eng.abstr-s13-r2-t2.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.90500674.eng.abstr-s14-t1",
"normalized": []
}
] |
DerHautarzt.90500701.eng.abstr
|
DerHautarzt.90500701.eng.abstr
|
[
{
"id": "DerHautarzt.90500701.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Natural and artificial UV radiation are environmental factors with both beneficial and harmful biological effects . This article will explain the physical measurement quantities and their relation to the biologically effective dose and will summarize the present technical state of the art of personal UV monitoring . In practical use are dosimeters based on polysulphone , a polymer which undergoes changes in its optical properties upon irradiation with UV . Other systems determine the UV dose by quantifying damage induced in Bacillus subtilis spores upon UV exposure . An electronic UV sensor represents a new and interesting development . Personal UV dosimeters will become an useful tool in both clinical and scientific areas within dermatology ."
],
"offsets": [
[
0,
753
]
]
}
] |
[
{
"id": "DerHautarzt.90500701.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"radiation"
],
"offsets": [
[
26,
35
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0851346"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"measurement"
],
"offsets": [
[
155,
166
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242485"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"art"
],
"offsets": [
[
286,
289
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003826"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"physical measurement"
],
"offsets": [
[
146,
166
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0203910"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"use"
],
"offsets": [
[
331,
334
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042153"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"polysulphone"
],
"offsets": [
[
359,
371
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0137907"
},
{
"db_name": "UMLS",
"db_id": "C0137909"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"polymer"
],
"offsets": [
[
376,
383
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032521"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"irradiation"
],
"offsets": [
[
439,
450
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034618"
},
{
"db_name": "UMLS",
"db_id": "C0851346"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Bacillus"
],
"offsets": [
[
530,
538
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004587"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"spores"
],
"offsets": [
[
548,
554
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038027"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"Bacillus subtilis"
],
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[
530,
547
]
],
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{
"db_name": "UMLS",
"db_id": "C0004595"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"electronic"
],
"offsets": [
[
577,
587
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013850"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"development"
],
"offsets": [
[
631,
642
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
},
{
"db_name": "UMLS",
"db_id": "C0020119"
}
]
},
{
"id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"dermatology"
],
"offsets": [
[
740,
751
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011627"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500701.eng.abstr-s2-r1-t3.1-t1.1",
"type": "method_of",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s2-r2-t3.1-t1.1",
"type": "measures",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r1-t4.1-t2.2",
"type": "uses",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s3-t4",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r2-t1.1-t4.2",
"type": "affects",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r3-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r4-t1.1-t4.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r5-t4.1-t1.1",
"type": "uses",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s3-t4",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r6-t1.1-t2.2",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s3-r7-t4.1-t2.1",
"type": "uses",
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"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-r2-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-r3-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500701.eng.abstr-s4-r4-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500701.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.90500701.eng.abstr-s6-t1",
"normalized": []
}
] |
DerHautarzt.90500715.eng.abstr
|
DerHautarzt.90500715.eng.abstr
|
[
{
"id": "DerHautarzt.90500715.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Aim of the present study was a comparison of four quality of life ( QoL ) questionnaires in 228 patients with psoriasis ( PSO , n=148) and atopic dermatitis ( AD , n=80) regardings feasibility , discriminant validity and sensitivity to change . Evaluating were performed before and after treatment in clinic . The following questionaires were compared . 1 ) Freiburg Quality of Life Assessment for Dermatoses ( FLQA-d ) , 2 ) Dermatology Life Quality Index ( DLQI ) , 3 ) Chronic Skin Disease Questionnaire ( CSDQ ) and 4 ) questionnaire on everyday life ( ALLTAG ) . All questionnaires were able to discriminate significant reductions of QoL in PSO and AD , as compared to controls . In parallel to the clinical improvement , all questionnaires showed QoL improvements as well , i.e. the questionnaires were sensitive to change . However , not all of the DLQI and ALLTAG scales were sensitive to change . Also , in some cases part of the scales of these questionnaires could not be calculated due to missing data . Otherwise , all questionnaires were valid and easy to handle . Thus , QoL of patients with PSO and AD can reliably be assessed by various questionnaires . Decisive for selection are the aim and the design of the study ."
],
"offsets": [
[
0,
1235
]
]
}
] |
[
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"life"
],
"offsets": [
[
61,
65
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376558"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"questionnaires"
],
"offsets": [
[
74,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034394"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
96,
104
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"psoriasis"
],
"offsets": [
[
110,
119
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"dermatitis"
],
"offsets": [
[
146,
156
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011603"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"sensitivity"
],
"offsets": [
[
221,
232
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036667"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"atopic dermatitis"
],
"offsets": [
[
139,
156
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011615"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"quality of life"
],
"offsets": [
[
50,
65
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034380"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
288,
297
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"after treatment"
],
"offsets": [
[
282,
297
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001758"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Life"
],
"offsets": [
[
378,
382
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376558"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"Assessment"
],
"offsets": [
[
383,
393
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028708"
}
]
},
{
"id": "DerHautarzt.90500715.eng.abstr-s4-t3",
"type": "umlsterm",
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] |
DerHautarzt.90500728.eng.abstr
|
DerHautarzt.90500728.eng.abstr
|
[
{
"id": "DerHautarzt.90500728.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the past few years , bath PUVA has become established as an effective treatment for various dermatoses and especially for psoriasis . Using 3,4 , 5 trimethylpsoralen ( TMP ) in combination with subsequent UVA irradiation , a shower PUVA has been developed as an alternative in local PUVA therapy . This involves moistening the patient's skin - with the exception of the head and neck area - in a shower using water containing psoralen ( TMP concentration 0,27 mg/l ) . The advantages of shower PUVA method are that time , space and cost savings are possible and that only a slight amount of physical exertion is required by the patient standing in the shower compared to immersing the whole body during bath PUVA therapy . The efficacy and practicability of shower PUVA were evaluated using the minimal phototoxic dose ( MPD ) for healthy volunteers assessing water temperature ( 33-38 °C), shower time ( 5-10 min ) , and UVA dose ( 0,06-1,0 J/cm2). Additionally , the time course of TMP-induced photosensitivity was observed over a period of 4 hours after the shower . Using a TMP concentration of 0,27 mg/l , the MPD for skin type I-II lay between 0,125-0,375 J/cm2 and for skin type III-IV between 0,375-1,0 J/cm2. Photosensitivity was induced by shower PUVA within 5-10 minutes shower time and at 33-38 °C water temperature . MPD exhibited an inverse correlation to temperature but no differences were apparent for shower times between 5 and 10 minutes . Photosensitivity completely disappeared within 2 hours . Minimal phototoxic doses using TMP in shower PUVA are comparable with classical bath PUVA when taking skin type into account . These results support the therapeutic use of shower PUVA using TMP ."
],
"offsets": [
[
0,
1718
]
]
}
] |
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] |
DerHautarzt.90500733.eng.abstr
|
DerHautarzt.90500733.eng.abstr
|
[
{
"id": "DerHautarzt.90500733.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 69-year-old woman presented with widespread symmetrical papular lesions in submammary and inguinal areas . History revealed that the disease had only been present for a few years . A skin biopsy showed focal suprabasal acantholysis , dyskeratosis up to the horny layer and in part parakeratotic hyperkeratosis . The patient had no further evidence for Darier disease , Hailey-Hailey disease or pemphigus vegetans . In particular , characteristic lesions of Darier disease of hands and nails were absent . We found several reports in the literature describing similar skin lesions in intertriginous and genital areas with histological evidence of acantholytic dyskeratosis under various terms . This report discusses the difference between these cases and the differential diagnoses , in particular Darier disease . We propose to designate cases of intertriginous papulosis with histological proof of acantholytic dyskeratosis but without further evidence of Darier disease as intertriginous acantholytic dyskeratosis ."
],
"offsets": [
[
0,
1020
]
]
}
] |
[
{
"id": "DerHautarzt.90500733.eng.abstr-s1-t1",
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"woman"
],
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[
14,
19
]
],
"normalized": [
{
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"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.90500733.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"History"
],
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[
109,
116
]
],
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{
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},
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}
]
},
{
"id": "DerHautarzt.90500733.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"disease"
],
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135,
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]
],
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[] |
[] |
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DerHautarzt.90500739.eng.abstr
|
DerHautarzt.90500739.eng.abstr
|
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] |
[] |
[] |
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] |
DerHautarzt.90500743.eng.abstr
|
DerHautarzt.90500743.eng.abstr
|
[
{
"id": "DerHautarzt.90500743.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 47 year old female with a history of hay fever and a family history of atopic eczema developed localized pruritic eczematous lesions over a three year period . The lesions became generalized within just three months . Episodes of recurrent erythroderma followed and became resistant towards any therapy . Many immediate and some delayed hypersensitivity reactions were diagnosed . In the peripheral blood , leukocytosis and hypereosinophilia were observed . In addition , levels of total IgE were highly increased in serum . Immunophenotyping of the peripheral blood T cells revealed evidence for a clonal expansion of highly activated CD4+ T cells with reduced CD2 and CD5 surface expression . After a three-year course of severe disease , the diagnosis of a pleomorphic T cell lymphoma of the small-cell variant was established by histological examination and a polymerase-chain rection technique to determine the rearrangements of the chain of the T cell receptor . Moreover , analysis of cytokine gene expression suggested that the high IgE concentrations and eosinophil numbers observed in this patient were likely due to an increased IL-5 and IL-13 production by lymphoma T cells ."
],
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[
0,
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]
]
}
] |
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},
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},
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"id": "DerHautarzt.90500743.eng.abstr-s9-r71-t15.1-t1.1",
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},
{
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},
{
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},
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"id": "DerHautarzt.90500743.eng.abstr-s9-r75-t3.1-t5.1",
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},
{
"id": "DerHautarzt.90500743.eng.abstr-s9-r76-t10.1-t13.1",
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{
"id": "DerHautarzt.90500743.eng.abstr-s9-r77-t3.1-t12.1",
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},
{
"id": "DerHautarzt.90500743.eng.abstr-s9-r78-t1.1-t9.1",
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}
] |
DerHautarzt.90500748.eng.abstr
|
DerHautarzt.90500748.eng.abstr
|
[
{
"id": "DerHautarzt.90500748.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Digital ischmia with gangrene of one or several fingertips has been described as a paraneoplastic syndrome associated with various malignant tumors , especially adenocarcinomas . Most often this paraneoplastic syndrome represents the first symptom of an occult neoplasia in an advanced stage . We present the case of an 83 year-old patient with digital ischemia and gangrenous fingertips in association with a latent adenocarcinoma of the uterus and metastatic involvement of the paraaortal lymph nodes . Acute occurrence of digital ischemia and gangrene without pathological laboratory findings and negative past medical history concerning cardiovascular-induced emboli , arteriosclerotic occlusion , or rheumatologic and autoimmune diseases should suggest this paraneoplastic syndrome and lead to thorough search for an underlying tumor ."
],
"offsets": [
[
0,
840
]
]
}
] |
[
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t1",
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"text": [
"gangrene"
],
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21,
29
]
],
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t2",
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"syndrome"
],
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98,
106
]
],
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t3",
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"malignant"
],
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131,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t4",
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"text": [
"tumors"
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141,
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{
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t5",
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"adenocarcinomas"
],
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161,
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"db_id": "C0001418"
}
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"id": "DerHautarzt.90500748.eng.abstr-s1-t6",
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"paraneoplastic syndrome"
],
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83,
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-t7",
"type": "umlsterm",
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"malignant tumors"
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131,
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"id": "DerHautarzt.90500748.eng.abstr-s2-t1",
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},
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"id": "DerHautarzt.90500748.eng.abstr-s2-t2",
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s2-t3",
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"neoplasia"
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"id": "DerHautarzt.90500748.eng.abstr-s2-t4",
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"stage"
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"id": "DerHautarzt.90500748.eng.abstr-s2-t5",
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"id": "DerHautarzt.90500748.eng.abstr-s3-t1",
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"ischemia"
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]
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}
]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"gangrenous"
],
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],
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}
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s3-t4",
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"association"
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]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s3-t5",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s3-t6",
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"text": [
"uterus"
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]
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{
"id": "DerHautarzt.90500748.eng.abstr-s3-t7",
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},
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"id": "DerHautarzt.90500748.eng.abstr-s3-t8",
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"lymph"
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{
"id": "DerHautarzt.90500748.eng.abstr-s3-t9",
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"lymph nodes"
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{
"id": "DerHautarzt.90500748.eng.abstr-s4-t1",
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"occurrence"
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]
},
{
"id": "DerHautarzt.90500748.eng.abstr-s4-t2",
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{
"id": "DerHautarzt.90500748.eng.abstr-s4-t3",
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{
"id": "DerHautarzt.90500748.eng.abstr-s4-t4",
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{
"id": "DerHautarzt.90500748.eng.abstr-s4-t5",
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{
"id": "DerHautarzt.90500748.eng.abstr-s4-t7",
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s4-t8",
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"id": "DerHautarzt.90500748.eng.abstr-s4-t9",
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"id": "DerHautarzt.90500748.eng.abstr-s4-t10",
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s4-t11",
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s4-t12",
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],
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030472"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500748.eng.abstr-s1-r1-t2.1-t7.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.90500748.eng.abstr-s4-t2",
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},
{
"id": "DerHautarzt.90500748.eng.abstr-s1-r2-t2.1-t6.1",
"type": "degree_of",
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{
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{
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{
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{
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{
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{
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{
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{
"id": "DerHautarzt.90500748.eng.abstr-s2-r10-t2.1-t1.1",
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{
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{
"id": "DerHautarzt.90500748.eng.abstr-s2-r13-t1.1-t5.1",
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DerHautarzt.90500769.eng.abstr
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DerHautarzt.90500769.eng.abstr
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DerHautarzt.90500779.eng.abstr
|
DerHautarzt.90500779.eng.abstr
|
[
{
"id": "DerHautarzt.90500779.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Congenital melanocytic nevi are benign skin tumours with a population-based prevalence of 1-6% . They run an increased life-time risk of transformation into malignant melanoma . Additionally , they can be associated with an involvement of the leptomeninges ( neurocutaneous melanosis ) , and may cause considerable cosmetic and psychic problems . In contrast to the past , the risk of congenital melanocytic nevi developing into melanoma is now regarded as well-established . Thus , excision is recommended whenever possible . Large lesions which do not allow complete excision should be treated by dermabrasion within the first weeks of life ."
],
"offsets": [
[
0,
644
]
]
}
] |
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"id": "DerHautarzt.90500779.eng.abstr-s2-t3",
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[] |
[] |
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] |
DerHautarzt.90500791.eng.abstr
|
DerHautarzt.90500791.eng.abstr
|
[
{
"id": "DerHautarzt.90500791.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The present study examined the effectiveness of combined dermatological and behavioural medicine therapy on the skin status and disease-specific stress of eighty-six patients with psoriasis and fifty-eight patients with atopic dermatitis who were hospitalized in the PsoriSol Clinic , Hersbruck , Germany . In addition to receiving instruction about their stain disease , the patients were offered , practice in relaxation techniques , social contacts and scratching control as well as individual psychological counselling . The clinical change was assessed by PASI and SCORAD , respectively . The Marburg questionnaire for coping with skin diseases ( MHF ) and a questionnaire for health-related control attributes ( GKUe-S ) served as psychometric measures . Patients showed significant improvement in skin status and psychosocial parameters in pre-post comparison . Social fears , avoidance and helplessness were reduced by significant improvement of the emotional status in both groups . Patients with psoriasis also showed an increase in internal control attributes . Dermatological treatment combined with behavioural medicine therapy can be considered an effective method in patients with atopic dermatitis and psoriasis ."
],
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[
0,
1229
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.90500798.eng.abstr
|
DerHautarzt.90500798.eng.abstr
|
[
{
"id": "DerHautarzt.90500798.eng.abstr-passage-0",
"type": "abstract",
"text": [
"From 1990 to 1992 the allergy profile of 1042 prospective hairdressers ( personal and family history , atopic skin , serum IgE , patch and prick tests ) was determined and their occupational suitability was evaluated . Up to 1997 a follow up of 375 hairdressers was obtained by way of questionnaires , re-examination , official reports and expert opinions of the social accident insurance . The frequency of initial eczema was 30% . A change of occupation on account of hairdresser eczema was documented in 11% . The prognostic evaluation of occupational suitability proved to be unsatisfactory . In this longitudinal study , the frequency of pre-occupational skin symptoms increased from 13 to 18% . The other atopic criteria indicated no uniform tendency . There was a significant increase in nickel allergy from 18.7 to 45.5% resulting partly from sensitization after entering the occupation and partly from an increase in nickel allergy at time of entry . Both atopic skin and pre-occupational nickel allergy increase the risk of hairdresser eczema , it is not so great as to justify disrading such young peoply from entering the profession ."
],
"offsets": [
[
0,
1146
]
]
}
] |
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] |
DerHautarzt.90500809.eng.abstr
|
DerHautarzt.90500809.eng.abstr
|
[
{
"id": "DerHautarzt.90500809.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 26-year old patient who suffered from purpura for four years evolved into the complete clinical picture of Henoch-Schoenlein-purpura in the past two years . A causative agent was never found . Multiple therapeutic approaches including systemic steroids , azathioprine as well as pentoxyfylline failed to control the arthralgias , intestinal symptoms and skin lesions . Therefore dapsone therapy was initiated at a dosage of 100 mg daily after checking the glucose-6-phosphate-dehydrogenase and with regular control of the blood methemoglobin level . Within two weeks , the patient's symptoms completetly cleared , he has now been in remission for the past six months . As noted elsewhere , dapsone is an effective therapy for severe cases of Henoch-Schoenlein- purpura ."
],
"offsets": [
[
0,
772
]
]
}
] |
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"old"
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{
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"patient"
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[
14,
21
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}
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s1-t3",
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"text": [
"purpura"
],
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40,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500809.eng.abstr-s3-t1",
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"therapeutic"
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s3-t2",
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"steroids"
],
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]
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},
{
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"text": [
"azathioprine"
],
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257,
269
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],
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}
]
},
{
"id": "DerHautarzt.90500809.eng.abstr-s3-t4",
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"text": [
"arthralgias"
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],
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}
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},
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"symptoms"
],
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s3-t6",
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"text": [
"skin"
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356,
360
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t1",
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"dapsone"
],
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381,
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],
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}
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t2",
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"therapy"
],
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389,
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]
},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t3",
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"text": [
"control"
],
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]
],
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]
},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"blood"
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}
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"methemoglobin"
],
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530,
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-t6",
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"methemoglobin"
],
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},
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"id": "DerHautarzt.90500809.eng.abstr-s4-t7",
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},
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"id": "DerHautarzt.90500809.eng.abstr-s5-t1",
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"id": "DerHautarzt.90500809.eng.abstr-s6-t1",
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"dapsone"
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s6-t3",
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"purpura"
],
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763,
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]
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{
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]
}
] |
[] |
[] |
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},
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},
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},
{
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},
{
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-r19-t5.1-t2.1",
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},
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},
{
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},
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s4-r23-t7.1-t2.1",
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},
{
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},
{
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},
{
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},
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},
{
"id": "DerHautarzt.90500809.eng.abstr-s6-r1-t1.1-t2.1",
"type": "affects",
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},
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"id": "DerHautarzt.90500809.eng.abstr-s6-r2-t1.1-t2.1",
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},
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"arg2_id": "DerHautarzt.90500809.eng.abstr-s6-t1",
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}
] |
DerHautarzt.90500812.eng.abstr
|
DerHautarzt.90500812.eng.abstr
|
[
{
"id": "DerHautarzt.90500812.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 7-year-old otherwise healthy girl presented with a 2-year history of an ILVEN ( inflammatory linear verrucous epidermal nevus ) located on the inner part of her right upper arm . The diagnosis was histologically confirmed . Different conservative therapeutic strategies with corticosteroids , antibiotics and antimycotics produced little or no improvement . Because of encouraging reports describing the successful use of 0.005% calcipotriol ointment in patients with ILVEN , we treated our patient with this regimen . After 4 weeks we could recognize a impressive improvement and after 8 weeks the ILVEN had nearly completely disappeared . 25 weeks after withdrawal of calcipotriol , no relapse had occurred . The dramatic response to calcipotriol suggests some pathological links between ILVEN and psoriasis ."
],
"offsets": [
[
0,
813
]
]
}
] |
[
{
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"history"
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60,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nevus"
],
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122,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s1-t3",
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"text": [
"right"
],
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163,
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]
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}
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},
{
"id": "DerHautarzt.90500812.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"arm"
],
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175,
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]
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}
]
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"id": "DerHautarzt.90500812.eng.abstr-s2-t1",
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"diagnosis"
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-t1",
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249,
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"corticosteroids"
],
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277,
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]
],
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"db_id": "C0001617"
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},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"antibiotics"
],
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295,
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]
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"db_id": "C0003232"
}
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"id": "DerHautarzt.90500812.eng.abstr-s4-t1",
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417,
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s4-t2",
"type": "umlsterm",
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"calcipotriol"
],
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431,
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],
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}
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{
"id": "DerHautarzt.90500812.eng.abstr-s4-t3",
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"ointment"
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"patient"
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{
"id": "DerHautarzt.90500812.eng.abstr-s6-t1",
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"calcipotriol"
],
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]
],
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]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"type": "umlsterm",
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"calcipotriol"
],
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]
],
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}
]
},
{
"id": "DerHautarzt.90500812.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"psoriasis"
],
"offsets": [
[
802,
811
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033860"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500812.eng.abstr-s1-r1-t3.1-t1.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s1-r2-t1.2-t1.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s2-t1",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s1-r3-t3.1-t1.2",
"type": "location_of",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-r1-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s7-t2",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-r2-t1.1-t3.1",
"type": "uses",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s3-r3-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s4-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500812.eng.abstr-s4-r2-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500812.eng.abstr-s7-t2",
"arg2_id": "DerHautarzt.90500812.eng.abstr-s7-t1",
"normalized": []
}
] |
DerHautarzt.90500841.eng.abstr
|
DerHautarzt.90500841.eng.abstr
|
[
{
"id": "DerHautarzt.90500841.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Today the management of hemangiomas is still a great challenge for physicians , even for the most experienced of clinicians . With the introduction of lasers , new ways of treating hemangiomas have been found . Four case reports document the importance of early treatment . In addition , the differentiated use of various laser systems and their effects , limitations , and side effects are shown and discussed ."
],
"offsets": [
[
0,
412
]
]
}
] |
[
{
"id": "DerHautarzt.90500841.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"hemangiomas"
],
"offsets": [
[
24,
35
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"physicians"
],
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[
67,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031831"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"lasers"
],
"offsets": [
[
151,
157
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"hemangiomas"
],
"offsets": [
[
181,
192
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"treatment"
],
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[
262,
271
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"case reports"
],
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[
216,
228
]
],
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{
"db_name": "UMLS",
"db_id": "C0007320"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"use"
],
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[
307,
310
]
],
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"db_name": "UMLS",
"db_id": "C0042153"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
322,
327
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.90500841.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"side effects"
],
"offsets": [
[
374,
386
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500841.eng.abstr-s1-r1-t1.1-t2.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.90500841.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500841.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500841.eng.abstr-s1-r2-t2.1-t1.1",
"type": "diagnoses",
"arg1_id": "DerHautarzt.90500841.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.90500841.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500841.eng.abstr-s2-r1-t1.1-t2.1",
"type": "causes",
"arg1_id": "DerHautarzt.90500841.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500841.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500841.eng.abstr-s4-r1-t1.1-t3.1",
"type": "causes",
"arg1_id": "DerHautarzt.90500841.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500841.eng.abstr-s4-t3",
"normalized": []
}
] |
DerHautarzt.90500848.eng.abstr
|
DerHautarzt.90500848.eng.abstr
|
[
{
"id": "DerHautarzt.90500848.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The microcirculation of human skin tumours can be visualized with noninvasive methods from clinical microcirculation research ( capillaroscopy and laser Doppler fluxmetry ( LDF ) . The latter can also be used to measure the blood flow in such tumours . This prospective study was designed to evaluate melanoma-associated cutaneous neoangiogenesis . We studied the microcirculation of 114 pigmented skin tumours in 103 patients ( 63 women , 40 men ) averaging 38.8 +/- 21.1 years of age . On the basis of histological findings , we diagnosed melanocytic naevus in 86 cases and malignant melanoma in 28. The malignant melanoma was characterized by a chaotic arrangement of the capillaries , which were dilated and formed corkscrew-shaped or glomerular structures . In the transitional area between healthy and cancerous areas there was hypervascularization . The capillaries of the melanoma appeared to be more permeable towards the low-molecular-weight , water-soluble sodium fluorescein . Laser Doppler flux , a measure of cutaneous circulation in the upper 2 mm of the skin , is higher in the centre of the melanoma than in either the middle of a melanocytic naevus ( p 0.0005 ) or in neighbouring healthy skin areas ( p 0.005 ) . In the future , antiangiogenetic therapy strategies could play a significant role in the treatment of malignant melanoma . These methods provide a reliable means of evaluating the specific antiangiogenetic efficacy of treatments for cutaneous melanoma ."
],
"offsets": [
[
0,
1485
]
]
}
] |
[
{
"id": "DerHautarzt.90500848.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"microcirculation"
],
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[
4,
20
]
],
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{
"db_name": "UMLS",
"db_id": "C0025962"
}
]
},
{
"id": "DerHautarzt.90500848.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"human"
],
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[
24,
29
]
],
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{
"db_name": "UMLS",
"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.90500848.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
30,
34
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500848.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"tumours"
],
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[
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[] |
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DerHautarzt.90500853.eng.abstr
|
DerHautarzt.90500853.eng.abstr
|
[
{
"id": "DerHautarzt.90500853.eng.abstr-passage-0",
"type": "abstract",
"text": [
"7 patients ( 5 female , 2 male ; age : 22-81 years ; average age=58,1 J ) with recurrent necrotizing ANCA-negative , non leucocytoclastic vasculitis , were enrolled into this study . Disease was resistant to prior conservative therapy , and therefore patients received high dose intravenous immunoglobulin ( IVIG ) - ( dose : 1,0 g/kg body weight daily dose 0,25 g/kg body weight over 4 consecutive days ) . All patients responded rapidly to this therapeutic regimen . Specifically immediate pain relief was striking . Complete clearance of disease was observed in 5 out of 7 patients within 6 months while receiving IVIG ( 0,5 g/kg body weight ) every 4 weeks for one year . In 2 out of 5 patients ulceration and vasculitis healed completly and therapy could be stopped after 6 months . In one patient treatment had to be discontinued due to decreasing kidney function . The data presented demonstrate that IVIG is an effective and valuable therapeutic modality in treatment of severe vasculitis resistant to conventional therapy . However consideration of costs , effectiveness and possible side effects is needed for this therapeutic regime ."
],
"offsets": [
[
0,
1145
]
]
}
] |
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],
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] |
DerHautarzt.90500859.eng.abstr
|
DerHautarzt.90500859.eng.abstr
|
[
{
"id": "DerHautarzt.90500859.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Chronic venous insufficiency ( CVI ) can cause ulcers of the lower limb having the character of a full thickness wound involving the subcutaneous tissues and fat . Healing requires wound contraction , connective tissue formation and finaly reepithelialisation . To induce wound healing , on an underlying disturbed environment due to longterm effects of CVI , artificial stimuli may be needed . In a placebo controlled study we tried topical application of autologous PDWHF ( platelet derived wound healing factors ) , to achieve ulcer healing and improve the microangiopathy surrounding of the ulcer area , as there are decreased number of skin capillaries and reduction in cutaneous vascular reserve . Alterations of cutaneous circulation during the course of the study were documented by capillaroscopy , transcutaneous oxygen pressure and laser Doppler flux ( LDF ) measurements . We were able to recruite 15 patients all suffering from chronic nonhealing venous stasis ulcers . Eleven of the 15 patients agreed to participate in a placebo-controlled double blind study , whereas 4 patients agreed to participate only if they would be treated with PDWHF . The median age and duration of ulceration of the 6 patients ( 3 male/ 3 female ) treated with placebo were 71 years and 1089 days . The median age and duration of ulceration of the 9 patients ( 1 male/ 8 females ) treated with PDWHF were 66 years and 732 days . Duration of therapy for the PDWHF group was 91 days , as compared to 154 days for the placebo group . Despite 2 completely healed ulcers , the expensive treatment did not reveal any significant clinical advantage . In den PDWHF group an ulcer area of 26.9 cm2 was measured at the beginning , of 26.2 cm2 at the end ; in the placebo group , 34.7 cm2 and 35.5 cm2. The nonsignificant increase of the capillary density at the ulcer border in the active group as well as the increase in the tcPO2, in contrast to little change in both parameters in the placebo group , suggests neoangiogenic abilities to PDWHF , secondarily leading to a better blood distribution with higher oxygen tension ."
],
"offsets": [
[
0,
2110
]
]
}
] |
[
{
"id": "DerHautarzt.90500859.eng.abstr-s1-t1",
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"text": [
"ulcers"
],
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[
47,
53
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041582"
}
]
},
{
"id": "DerHautarzt.90500859.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"limb"
],
"offsets": [
[
67,
71
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015385"
}
]
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"id": "DerHautarzt.90500859.eng.abstr-s12-r70-t1.1-t9.1",
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}
] |
DerHautarzt.90500873.eng.abstr
|
DerHautarzt.90500873.eng.abstr
|
[
{
"id": "DerHautarzt.90500873.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Diagnosis of herpes zoster needs to be rapid when effective antiviral chemotherapy is being considered . Patients with atypical clinical features can often only be diagnosed by virological methods . In the present study , vesicle specimens of 100 patients with zoster were analysed by detecting viral DNA using polymerase chain reaction ( PCR ) . The findings were compared with those obtained by traditional virological and serological methods . PCR results confirmed the clinical diagnosis of zoster in 95% . Primers selected from varicella-zoster virus ( VZV ) gene 28 proved to be most sensitive . The sensitivity of virus culture was 20% ( specificity 100% ) and of direct immunofluorescent VZV-specific antigen staining in vesicle samples 82% ( specificity 76% ) . There was a serological response to specific IgM and IgA antibodies in 48% within four days after the onset of rash . These findings suggest that PCR is the method of choice for rapid laboratory diagnosis of zoster ."
],
"offsets": [
[
0,
987
]
]
}
] |
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},
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"id": "DerHautarzt.90500873.eng.abstr-s1-t2",
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"id": "DerHautarzt.90500873.eng.abstr-s1-t3",
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"id": "DerHautarzt.90500873.eng.abstr-s1-t5",
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"id": "DerHautarzt.90500873.eng.abstr-s3-t2",
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"id": "DerHautarzt.90500873.eng.abstr-s3-t3",
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}
] |
[] |
[] |
[
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{
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DerHautarzt.90500879.eng.abstr
|
DerHautarzt.90500879.eng.abstr
|
[
{
"id": "DerHautarzt.90500879.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pyoderma gangraenosum is a rare , chronic type of skin ulceration of unknown aetiology . It occasionally appears following trauma . There are no set standards for the treatment of pyoderma gangraenosum . It is essential to consider acuteness of progression as well as underlying systemic diseases and possible drug side effects before initiating a therapy . Immunosuppressive as well as immunomodulating agents are most often used , with varying degrees of success . We report a 45-year-old patient who suffered from an extensive posttraumatic pyoderma gangraenosum after cardiac bypass operation . With short-term combination therapy consisting of high dose intravenous immunoglobulins and systemic corticosteroids , the progression of the disease could be stopped within a few days ."
],
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]
]
}
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[] |
[] |
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DerHautarzt.90500884.eng.abstr
|
DerHautarzt.90500884.eng.abstr
|
[
{
"id": "DerHautarzt.90500884.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 28 year old patient developed a severe bullous exanthem and enanthem combined with hepatitis , fever and blood count abnormalities after taking carbamazepine and consumption of heroin and alcohol . After discontinuing carbamazepine , prednisolone was given over a five day period accompanied by intravenous fluid and electrolyte substitution and local therapy which lead to improvement . Severe bullous skin reactions nowadays are classified into erythema exsudativum multiforme majus ( EEMM ) , Stevens-Johnson syndrome ( SJS ) , overlap Stevens-Johnson syndrome-toxic epidermal necrolysis ( SJS/TEN ) , TEN with maculae and TEN on large erythema , and they are most often caused by antibiotics and anticonvulsant drugs . Heroin and alcohol abuse alters host immunity which subsequently may increase susceptibility to allergic reactions . There is a high ( 40% ) mortality rate for TEN , and patients with organ involvement are at increased risk ."
],
"offsets": [
[
0,
950
]
]
}
] |
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[] |
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DerInternist.70380692.eng.abstr
|
DerInternist.70380692.eng.abstr
|
[
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]
}
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[] |
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DerInternist.80390403.eng.abstr
|
DerInternist.80390403.eng.abstr
|
[
{
"id": "DerInternist.80390403.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report an 18-year old woman with surgically proven primary hyperparathyroidism ( pHPT ) and normal intact parathyroid hormone ( iPTH ) serum levels . The reason for this rare biochemical presentation are possible biologically active amino-terminal parathyroid hormone polypeptide fragments not detected by the widely used two-site immunoradiometric parathyroid hormone assay ( PTH IRMA ) . Diagnosis and therapy of primary hyperparathyroidism therefore should not exclusively rest on the finding of hypercalcemia coupled with an elevated iPTH level ."
],
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[
0,
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]
]
}
] |
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"parathyroid"
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},
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},
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"id": "DerInternist.80390403.eng.abstr-s1-t9",
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],
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109,
128
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}
]
},
{
"id": "DerInternist.80390403.eng.abstr-s2-t1",
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"amino-terminal"
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[
236,
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],
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},
{
"id": "DerInternist.80390403.eng.abstr-s2-t2",
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{
"id": "DerInternist.80390403.eng.abstr-s2-t3",
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"parathyroid"
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{
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{
"id": "DerInternist.80390403.eng.abstr-s2-t5",
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"id": "DerInternist.80390403.eng.abstr-s2-t9",
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"id": "DerInternist.80390403.eng.abstr-s2-t12",
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"PTH"
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{
"id": "DerInternist.80390403.eng.abstr-s2-t13",
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"IRMA"
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"id": "DerInternist.80390403.eng.abstr-s2-t14",
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{
"id": "DerInternist.80390403.eng.abstr-s3-t3",
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{
"id": "DerInternist.80390403.eng.abstr-s3-t6",
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]
}
] |
[] |
[] |
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DerNervenarzt.00710001.eng.abstr
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DerNervenarzt.00710001.eng.abstr
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"id": "DerNervenarzt.00710001.eng.abstr-passage-0",
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"Andidepressants are not only effective in younger adults but also in older persons with depression . However there are pecularities , which have to be taken into account when treating older patients . The enhanced risk of side effects has to be balanced with the more serious consequences of an untreated depression in old age . The efficacy in older patients has been proven not only for tricyclic antidepressants but also for SSRI and other newer antidepressants . The easy handling , the side effect profile and the safety in overdose are advantages of SSRI and newer antidepressants , which become particularily important in old age . The advantages and disadvantages of different classes of antidepressants with regard to comorbidity and comedication are discussed . In older subjects , changes of dosage should be slower and for some , but not for all antidepressants , dosage should be lower ."
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0,
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[] |
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DerNervenarzt.00710009.eng.abstr
|
DerNervenarzt.00710009.eng.abstr
|
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"Functional brain imaging with positron emission tomography ( PET ) and single photon emission computerized tomography ( SPECT ) enables the in vivo study of specific neurochemical processes in the context of normal regulatory mechanisms and pathophysiological alterations of the brain . By combining these methods with pharmacological challenge-paradigms , the study of functional interactions of different neurotransmitter systems is possible . This review will present data from animal and healthy volunteer studies as well as first data from investigations in different patient populations with regard to this research direction . Especially , interactions of different neurotransmitter systems with the dopaminergic and the cholinergic system will be discussed . The database acquired so far confirms existing models of neuronal feedback -circuits , and the first clinical results are consistent with the hypothesis of an increased dopaminergic responsivity in schizophrenic patients . These results open up new perspectives for a further evaluation of treatment response predictors from drug -challenge studies and for the development of new drug treatments for neuropsychiatric disorders ."
],
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0,
1195
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DerNervenarzt.00710019.eng.abstr
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DerNervenarzt.00710019.eng.abstr
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] |
DerNervenarzt.00710038.eng.abstr
|
DerNervenarzt.00710038.eng.abstr
|
[
{
"id": "DerNervenarzt.00710038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Argyrophilic grain disease ( AGD ) is a frequently occurring degenerative illness of the aging human brain . It is accompanied by progressive pathological alterations of the cytsokeleton which are traceable to an abnormal phosphorylation of the microtubule associated tau protein . Histologically , it is possible with the help of suitable staining techniques to identify pathognomonic spindle-shaped cellular inclusions ( argyrophilic grains ) . These cellular inclusions display a typical cortical as well as subcortical distribution pattern . The goal of the present study is the retrospective evaluation of the clinical findings from 53 individuals with neuropathologically demonstrable AGD-related changes of the brain . Nearly one-half of the cases ( 49% ) was classifiable as demented in accordance with DSM IV-criteria . Moreover , the frequency of the dementia increased significantly in relation to the growing severity of the AGD-associated pathological cytoskeletal degeneration . These results confirm the assumption that AGD can cause degenerative changes ranging from cognitive impairment all the way to dementia . They also underscore the necessity of further prospective studies pertaining to the clinical aspects of this still enigmatic disease ."
],
"offsets": [
[
0,
1264
]
]
}
] |
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"id": "DerNervenarzt.00710038.eng.abstr-s2-t2",
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"id": "DerNervenarzt.00710038.eng.abstr-s2-t3",
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"id": "DerNervenarzt.00710038.eng.abstr-s2-t4",
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{
"id": "DerNervenarzt.00710038.eng.abstr-s4-t2",
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"id": "DerNervenarzt.00710038.eng.abstr-s5-t2",
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"id": "DerNervenarzt.00710038.eng.abstr-s7-t2",
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] |
[] |
[] |
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DerNervenarzt.00710044.eng.abstr
|
DerNervenarzt.00710044.eng.abstr
|
[
{
"id": "DerNervenarzt.00710044.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The term frontotemporal dementia is used to describe a primary degenerative form of dementia , which is characterized by typical clinical , neuropsychological , radiological and neuropathological features . Its onset is usually before the age of 65 years ; manifestations before the age of 30 years have rarely been described . We report the case of a 22-year old man , who showed symptoms of behavioural disorder such as social retreat , lack of initiative , mental rigidity , progressive reduction of speech , and stereotyped behaviour . The neuropsychological examination revealed disorders of the executive functions . The cerebral MRI investigations showed bifrontal atrophies corresponding with hypoperfusion areas on the SPECT . Other investigations including EEG , evoked potentials , duplex ultrasonography , cerebral angiography , laboratory tests and cerebrospinal fluid were normal . In the present case report we discuss the clinical presentation of frontotemporal dementia with early onset ."
],
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0,
1005
]
]
}
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] |
DerNervenarzt.00710050.eng.abstr
|
DerNervenarzt.00710050.eng.abstr
|
[
{
"id": "DerNervenarzt.00710050.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In spite of its serious sequelae , volatile substance abuse ( VSA ) attracts very little public attention in Germany . Our case report describes an adult male who inhaled propane for recreational purposes . Initially , he achieved short-lived euphoria and hallucinations . He compensated for the developing tolerance by increasing the dosage , finally consuming 5 litres of fluid propane daily . Getting such quantities was facilitated by his occupational access to propane . Since he abused the propane in an apartment house , he also exposed third parties to the danger of explosion . Clinical examination revealed disturbances in orientation , restricted perceptivity and concentration , reduced mnemonic performance , and psychomotor agitation . All these symptoms diminished during a 6-month follow-up . The relationship of his organic mental disorder to the abuse of propane was not clear , since he had also abused alcohol ."
],
"offsets": [
[
0,
931
]
]
}
] |
[
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24,
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],
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},
{
"id": "DerNervenarzt.00710050.eng.abstr-s1-t2",
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"text": [
"abuse"
],
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54,
59
]
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{
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105
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],
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{
"id": "DerNervenarzt.00710050.eng.abstr-s2-t1",
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"text": [
"adult"
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148,
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]
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DerNervenarzt.00710054.eng.abstr
|
DerNervenarzt.00710054.eng.abstr
|
[
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"The dopamine hypothesis of schizophrenia was based on the neuroleptical blockade of central dopamine D2 receptors . Brain imaging studies , however , generally failed to demonstrate a significant increase in central D2 receptors among schizophrenic patients . Using a novel approach , the group of Laruelle and Abi-Dargham was now able to demonstrate that schizophrenic patients have increased synaptic dopamine concentrations in the striatum . Endogenous dopamine competes with a radioligand for binding at dopamine D2 receptors ; compared to healthy control subjects , blockade of dopamine production in neuroleptic-naive schizophrenic patients induced a significantly higher increase in D2 binding of the infused radioligand , indicating higher endogenous synaptic dopamine . A similar increase in D2 binding was also observed in drug-free schizophrenics who had previously been treated with neuroleptics ; these patients also showed an increased density of striatal D2 receptors , most likely due to counteradaptive upregulation of D2 receptors during neuroleptic medication . The Columbia study provides an important indication of hyperdopaminergic function in schizophrenia ."
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DerNervenarzt.00710065.eng.abstr
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DerNervenarzt.00710065.eng.abstr
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{
"id": "DerNervenarzt.00710065.eng.abstr-passage-0",
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"If continuous seizure activity lasts longer than 5 minutes generalized tonic-clonic seizures require prompt treatment , if significant morbidity and mortality are to be avoided . The mortality varies ( mean : 20% ) depending on patient age and etiology . Control of status epilepticus is achieved by benzodiazepines in about 80% of cases : Lorazepam is recommended due to its longer-acting effects on the central nervous system . To maintain the anticonvulsive effect phenytoin is usually administered intravenously . Fosphenytoin ( not approved in Germany ) has advantages over phenytoin , because it can be given three times more rapidly and produces fewer side effects . The IV use of valproic acid in status epilepticus seems to be promising , but needs further evaluation . There is no generally accepted treatment protocol for the therapy of persistent seizure activity lasting more than 60 minutes ( i . e . , refractory status epilepticus ) . Usually phenobarbital , or general anesthesia with thiopental or pentobarbital are treatment recommendations . In recent reports , the administration of midazolam or propofol proved to be effective and well-tolerated ."
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[] |
[] |
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] |
DerNervenarzt.00710078.eng.abstr
|
DerNervenarzt.00710078.eng.abstr
|
[
{
"id": "DerNervenarzt.00710078.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Registration of the inhibitor of the catechol-O-methyltransfersase ( COMT ) tolcapone has been stopped due to the possible relationship of tolcapone treatment to three cases of fatal hepatitis . As a result , strong uncertainty has emerged among neurologists about the principle of COMT inhibition itself . We review data , especially on the remaining COMT inhibitor , entacapone , with regard to pre-clinical and clinical efficacy and safety ."
],
"offsets": [
[
0,
444
]
]
}
] |
[
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],
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20,
29
]
],
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]
},
{
"id": "DerNervenarzt.00710078.eng.abstr-s1-t2",
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"COMT"
],
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[
69,
73
]
],
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{
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}
]
},
{
"id": "DerNervenarzt.00710078.eng.abstr-s1-t3",
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"tolcapone"
],
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[
76,
85
]
],
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}
]
},
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],
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139,
148
]
],
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],
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]
},
{
"id": "DerNervenarzt.00710078.eng.abstr-s1-t6",
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],
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[
183,
192
]
],
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"db_id": "C0019158"
}
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s2-t1",
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"text": [
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],
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216,
227
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s2-t2",
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282,
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s2-t3",
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287,
297
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s3-t1",
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s3-t2",
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"COMT"
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352,
356
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s3-t3",
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s3-t4",
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],
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},
{
"id": "DerNervenarzt.00710078.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
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]
],
"normalized": [
{
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"db_id": "C0036043"
}
]
}
] |
[] |
[] |
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DerNervenarzt.00710084.eng.abstr
|
DerNervenarzt.00710084.eng.abstr
|
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[] |
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] |
DerNervenarzt.00710091.eng.abstr
|
DerNervenarzt.00710091.eng.abstr
|
[
{
"id": "DerNervenarzt.00710091.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Today the diagnosis of Creutzfeldt-Jakob disease ( CJD ) is proven only postmortem or by evidence of neuropathology . During the patient's lifetime EEG recordings or cerebrospinal fluid analysis may support the diagnosis . In most cases , T2-MRI scans show hyperintensities of the basal ganglia . A new imaging technique called diffusion-weighted MRI ( DWI ) has recently been established . The sensitivity of DWI was evaluated in five patients suspected of CJD . All five cases showed hyperintense signal changes in the basal ganglia on DWI sequences . These findings were more pronounced in DWI than in T2, FLAIR , or PD-weighted images . Thus , DWI seems to be the most sensitive sequence for detecting changes in patients with suspected CJD . Moreover , its short scanning time ensures that fewer artifacts occur , especially in the case of myoclonus ."
],
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[
0,
856
]
]
}
] |
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] |
[] |
[] |
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DerNervenarzt.00710105.eng.abstr
|
DerNervenarzt.00710105.eng.abstr
|
[
{
"id": "DerNervenarzt.00710105.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Stroke Unit concept of the German Neurological Society differs from its precedents in Scandinavia or the United Kingdom . Hallmarks of the German concept are very early onset of diagnosis and treatment , continuous surveillance of vital functions by bedside monitors and specialized care by a multiprofessional team . This comparison of two Stroke Units in Minden and Munich-Harlaching , working according to the new German concept , shows broad similarities in admission intervals , diagnostic procedures , treatment modalities and short term prognosis , with an exceedingly low in-hospital mortality of 3.4-5.6% and a high proportion of patients ( 64-69% ) leaving the hospital with Barthel scores above 70. Ongoing studies will show how this kind of Stroke Unit treatment compares to general wards ."
],
"offsets": [
[
0,
806
]
]
}
] |
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"treatment"
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{
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{
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] |
[] |
[] |
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] |
DerNervenarzt.00710112.eng.abstr
|
DerNervenarzt.00710112.eng.abstr
|
[
{
"id": "DerNervenarzt.00710112.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report about two female inpatients aged 58 and 24 , suffering from non-purulent meningoencephalitis , in the first case caused by varizella-zoster-virus , in the second case probably due to viral infection . Both patients developed a diffuse brain edema associated with a progressive loss of consciousness . The adjunctive treatment with dexamethasone led to rapid improvement of clinical symptoms . Computed tomography revealed a significant reduction of brain edema ."
],
"offsets": [
[
0,
472
]
]
}
] |
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"id": "DerNervenarzt.00710112.eng.abstr-s2-t4",
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{
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{
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}
] |
[] |
[] |
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] |
DerNervenarzt.00710116.eng.abstr
|
DerNervenarzt.00710116.eng.abstr
|
[
{
"id": "DerNervenarzt.00710116.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Eight patients with spontaneous spinal epidural hemorrhages are presented . All eight initially had suffered from severe neck or back pain . In seven cases , progressive neurological deficits had developed , some of which led to complete paraplegia . On all eight patients operations were performed . After an average of 11 weeks ' follow-up , full recovery from the preoperative pain and neurological deficits could be seen in 6 of the patients ."
],
"offsets": [
[
0,
447
]
]
}
] |
[
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6,
14
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{
"id": "DerNervenarzt.00710116.eng.abstr-s1-t2",
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],
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48,
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{
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39,
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"id": "DerNervenarzt.00710116.eng.abstr-s2-t2",
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"neck"
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121,
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129,
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{
"id": "DerNervenarzt.00710116.eng.abstr-s4-t2",
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273,
283
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"id": "DerNervenarzt.00710116.eng.abstr-s5-t1",
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}
] |
[] |
[] |
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"id": "DerNervenarzt.00710116.eng.abstr-s4-r1-t1.1-t2.1",
"type": "performs",
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},
{
"id": "DerNervenarzt.00710116.eng.abstr-s4-r2-t2.1-t1.1",
"type": "affects",
"arg1_id": "DerNervenarzt.00710116.eng.abstr-s5-t2",
"arg2_id": "DerNervenarzt.00710116.eng.abstr-s5-t1",
"normalized": []
}
] |
DerNervenarzt.00710123.eng.abstr
|
DerNervenarzt.00710123.eng.abstr
|
[
{
"id": "DerNervenarzt.00710123.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Anosognosia for hemiplegia ( AHP ) , i . e . , unawareness of motor deficits and associated disorders , has been frequently reported , predominantly following right hemispheric lesions . To a smaller extent , there are case reports of patients who give accounts of a feeling of strangeness concerning the contralesional limbs and sometimes attribute them to other persons . This \" positive-variant \" of AHP has been labeled \" somatoparaphrenia \" ( SP ) ."
],
"offsets": [
[
0,
454
]
]
}
] |
[
{
"id": "DerNervenarzt.00710123.eng.abstr-s1-t1",
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"text": [
"hemiplegia"
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16,
26
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]
},
{
"id": "DerNervenarzt.00710123.eng.abstr-s1-t2",
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"AHP"
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"id": "DerNervenarzt.00710123.eng.abstr-s3-t1",
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"disorders"
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{
"id": "DerNervenarzt.00710123.eng.abstr-s3-t2",
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"right"
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"db_id": "C0035621"
}
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"id": "DerNervenarzt.00710123.eng.abstr-s4-t1",
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"patients"
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"id": "DerNervenarzt.00710123.eng.abstr-s4-t2",
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"feeling"
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267,
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},
{
"id": "DerNervenarzt.00710123.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"limbs"
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320,
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{
"db_name": "UMLS",
"db_id": "C0015385"
}
]
},
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"id": "DerNervenarzt.00710123.eng.abstr-s4-t4",
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"persons"
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"id": "DerNervenarzt.00710123.eng.abstr-s4-t5",
"type": "umlsterm",
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"case reports"
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{
"id": "DerNervenarzt.00710123.eng.abstr-s5-t1",
"type": "umlsterm",
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"AHP"
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403,
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{
"db_name": "UMLS",
"db_id": "C0282484"
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]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710123.eng.abstr-s4-r1-t4.1-t5.1",
"type": "uses",
"arg1_id": "DerNervenarzt.00710123.eng.abstr-s4-t4",
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{
"id": "DerNervenarzt.00710123.eng.abstr-s4-r2-t1.1-t5.1",
"type": "uses",
"arg1_id": "DerNervenarzt.00710123.eng.abstr-s5-t1",
"arg2_id": "DerNervenarzt.00710123.eng.abstr-s4-t5",
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},
{
"id": "DerNervenarzt.00710123.eng.abstr-s4-r3-t4.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.00710123.eng.abstr-s4-t4",
"arg2_id": "DerNervenarzt.00710123.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerNervenarzt.00710123.eng.abstr-s4-r4-t1.1-t4.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.00710123.eng.abstr-s5-t1",
"arg2_id": "DerNervenarzt.00710123.eng.abstr-s4-t4",
"normalized": []
}
] |
DerNervenarzt.00710130.eng.abstr
|
DerNervenarzt.00710130.eng.abstr
|
[
{
"id": "DerNervenarzt.00710130.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on the history and clinical findings of an injecting drug abuser in the Canton of Zurich who presented with multiple deep abscesses in the arms and legs . A diagnosis of wound botulism was made based on his clinical presentation with a rapidly progressing descending paralysis starting at the cranial nerves , a neuromuscular junction disorder on neurophysiologic testing , and normal findings on lumbar puncture . Several cases of wound botulism have occured in IV drug abuse in Switzerland since 1997. We suspect subcutaneous injections of contaminated heroin containing Clostridium spores as sites of entry . Wound botulism caused by Clostridium botulinum is a rare cause of rapidly progressing , generalized , flaccid paralysis and should be considered in patients with a history of IV drug abuse presenting with descending paralysis ."
],
"offsets": [
[
0,
849
]
]
}
] |
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{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t1",
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"history"
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}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t2",
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"findings"
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[
38,
46
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"drug"
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63,
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{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t4",
"type": "umlsterm",
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"abscesses"
],
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132,
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"db_id": "C0000833"
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"arms"
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[
149,
153
]
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"db_name": "UMLS",
"db_id": "C0003792"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"legs"
],
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[
158,
162
]
],
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{
"db_name": "UMLS",
"db_id": "C0023216"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"diagnosis"
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167,
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"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"wound"
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180,
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"db_name": "UMLS",
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"db_name": "UMLS",
"db_id": "C0043250"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"botulism"
],
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186,
194
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"db_name": "UMLS",
"db_id": "C0006057"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"paralysis"
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277,
286
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"db_name": "UMLS",
"db_id": "C0030440"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"nerves"
],
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[
311,
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027769"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"disorder"
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345,
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"testing"
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"db_name": "UMLS",
"db_id": "C0039593"
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{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"findings"
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395,
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"puncture"
],
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[
414,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034117"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"cranial nerves"
],
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[
303,
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"db_name": "UMLS",
"db_id": "C0010268"
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"neuromuscular junction"
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[
322,
344
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],
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"db_name": "UMLS",
"db_id": "C0027869"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"lumbar puncture"
],
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[
407,
422
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],
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"db_name": "UMLS",
"db_id": "C0037943"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s2-t13",
"type": "umlsterm",
"text": [
"neuromuscular junction disorder"
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[
322,
353
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"db_name": "UMLS",
"db_id": "C0751950"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"wound"
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[
442,
447
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"db_name": "UMLS",
"db_id": "C0021501"
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"db_name": "UMLS",
"db_id": "C0043250"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"botulism"
],
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[
448,
456
]
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"db_name": "UMLS",
"db_id": "C0006057"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t3",
"type": "umlsterm",
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"drug"
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476,
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"db_name": "UMLS",
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"abuse"
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[
481,
486
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"db_name": "UMLS",
"db_id": "C0013146"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"Switzerland"
],
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[
490,
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"db_name": "UMLS",
"db_id": "C0039021"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"injections"
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538,
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"heroin"
],
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565,
571
]
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"db_name": "UMLS",
"db_id": "C0011892"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"Clostridium"
],
"offsets": [
[
583,
594
]
],
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"db_name": "UMLS",
"db_id": "C0009054"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"spores"
],
"offsets": [
[
595,
601
]
],
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{
"db_name": "UMLS",
"db_id": "C0038027"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"drug abuse"
],
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[
476,
486
]
],
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"db_name": "UMLS",
"db_id": "C0013146"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"subcutaneous injections"
],
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[
525,
548
]
],
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{
"db_name": "UMLS",
"db_id": "C0021499"
}
]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Wound"
],
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[
622,
627
]
],
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"db_name": "UMLS",
"db_id": "C0021501"
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t2",
"type": "umlsterm",
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"botulism"
],
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[
628,
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]
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"Clostridium"
],
"offsets": [
[
647,
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]
],
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"db_name": "UMLS",
"db_id": "C0009054"
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t4",
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t5",
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732,
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{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t6",
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"id": "DerNervenarzt.00710130.eng.abstr-s4-t7",
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{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t8",
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t9",
"type": "umlsterm",
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805,
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t10",
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"paralysis"
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838,
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t11",
"type": "umlsterm",
"text": [
"Clostridium botulinum"
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[
647,
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],
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710130.eng.abstr-s4-t12",
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"text": [
"drug abuse"
],
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800,
810
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013146"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-r1-t4.1-t2.1",
"type": "associated_with",
"arg1_id": "DerNervenarzt.00710130.eng.abstr-s4-t4",
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},
{
"id": "DerNervenarzt.00710130.eng.abstr-s1-r2-t6.1-t4.1",
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"id": "DerNervenarzt.00710130.eng.abstr-s4-r55-t9.1-t12.1",
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DerNervenarzt.00710138.eng.abstr
|
DerNervenarzt.00710138.eng.abstr
|
[
{
"id": "DerNervenarzt.00710138.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 1998 Minor et al. described a new variant of perilymphatic fistula : the \" superior canal dehiscence syndrome \" . This syndrome is clinically characterized by recurrent attacks of vertigo and oscillopsia induced by loud noises or stimuli that result in changes in intracranial or middle ear pressure . It is caused by a dehiscence of bone overlying the superior ( anterior ) semicircular canal . Due to this dehiscence , a third , mobile window ( in addition to the round and oval windows ) is formed , and changes in pressure are pathologically transduced to the anterior semicircular canal ."
],
"offsets": [
[
0,
596
]
]
}
] |
[
{
"id": "DerNervenarzt.00710138.eng.abstr-s1-t1",
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"Minor"
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{
"id": "DerNervenarzt.00710138.eng.abstr-s1-t2",
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"fistula"
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62,
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{
"id": "DerNervenarzt.00710138.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"syndrome"
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104,
112
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{
"id": "DerNervenarzt.00710138.eng.abstr-s2-t1",
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"syndrome"
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122,
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{
"id": "DerNervenarzt.00710138.eng.abstr-s2-t2",
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"vertigo"
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183,
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"id": "DerNervenarzt.00710138.eng.abstr-s2-t3",
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"noises"
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223,
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]
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{
"id": "DerNervenarzt.00710138.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"ear"
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290,
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"id": "DerNervenarzt.00710138.eng.abstr-s2-t5",
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"pressure"
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]
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{
"id": "DerNervenarzt.00710138.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"middle ear"
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283,
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{
"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710138.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"bone"
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337,
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{
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s3-t2",
"type": "umlsterm",
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"anterior"
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367,
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]
},
{
"id": "DerNervenarzt.00710138.eng.abstr-s3-t3",
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"semicircular canal"
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[
378,
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{
"db_name": "UMLS",
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]
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{
"id": "DerNervenarzt.00710138.eng.abstr-s4-t1",
"type": "umlsterm",
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"pressure"
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521,
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{
"id": "DerNervenarzt.00710138.eng.abstr-s4-t2",
"type": "umlsterm",
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"anterior"
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567,
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]
},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"oval windows"
],
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[
479,
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{
"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"semicircular canal"
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[
576,
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],
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{
"db_name": "UMLS",
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}
]
}
] |
[] |
[] |
[
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},
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"id": "DerNervenarzt.00710138.eng.abstr-s1-r3-t1.1-t3.1",
"type": "degree_of",
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{
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r1-t5.1-t6.1",
"type": "measurement_of",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r2-t6.1-t1.1",
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},
{
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r4-t1.1-t3.1",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r5-t6.1-t4.1",
"type": "connected_to",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r7-t3.1-t1.1",
"type": "result_of",
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"normalized": []
},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r8-t1.1-t2.1",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s2-r9-t4.1-t6.1",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-r1-t1.1-t3.1",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-r2-t3.1-t2.1",
"type": "connected_to",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-r3-t2.1-t3.1",
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},
{
"id": "DerNervenarzt.00710138.eng.abstr-s4-r4-t4.1-t3.1",
"type": "interconnects",
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"id": "DerNervenarzt.00710138.eng.abstr-s4-r5-t3.1-t4.1",
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"arg2_id": "DerNervenarzt.00710138.eng.abstr-s4-t4",
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}
] |
DerNervenarzt.00710151.eng.abstr
|
DerNervenarzt.00710151.eng.abstr
|
[
{
"id": "DerNervenarzt.00710151.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although alexithymia is found in patients with various somatic disorders , it remains unclear whether it is really related to organic disease - as proposed by the founders of the concept . [ 125 ] . As the interplay between the experience of emotion and possible adverse effects on health is a fundamental tenet of psychosomatic medicine , alexithymia remains an interesting concept to be further explored , especially concerning ( 1 ) possible pathways linking emotion to physical illness and ( 2 ) the neurobiologic basis of emotional information processing . Compared to the intense international discussion on the subject , in Germany there are still many doubts concerning alexithymia : while some clinicians question the validity of the whole concept , psychiatric and psychosomatic researchers seem unsure about alexithymia's role in their search for a physiological basis to the link between emotion and physical disease . Our review deals with the empirical literature concerning that possible association and tries to tie in their data with modern , neurobiologically founded insights into emotional information processing within the brain ."
],
"offsets": [
[
0,
1151
]
]
}
] |
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{
"id": "DerNervenarzt.00710151.eng.abstr-s1-t1",
"type": "umlsterm",
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"alexithymia"
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9,
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{
"id": "DerNervenarzt.00710151.eng.abstr-s1-t2",
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"patients"
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33,
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{
"id": "DerNervenarzt.00710151.eng.abstr-s1-t3",
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"disorders"
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63,
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"id": "DerNervenarzt.00710151.eng.abstr-s1-t4",
"type": "umlsterm",
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"disease"
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134,
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{
"id": "DerNervenarzt.00710151.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"emotion"
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242,
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"db_name": "UMLS",
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{
"id": "DerNervenarzt.00710151.eng.abstr-s3-t2",
"type": "umlsterm",
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"health"
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"id": "DerNervenarzt.00710151.eng.abstr-s3-t3",
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"medicine"
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"id": "DerNervenarzt.00710151.eng.abstr-s3-t4",
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"alexithymia"
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"db_name": "UMLS",
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"id": "DerNervenarzt.00710151.eng.abstr-s3-t5",
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"emotion"
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"id": "DerNervenarzt.00710151.eng.abstr-s3-t6",
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"id": "DerNervenarzt.00710151.eng.abstr-s3-t7",
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{
"id": "DerNervenarzt.00710151.eng.abstr-s3-t8",
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"information processing"
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"id": "DerNervenarzt.00710151.eng.abstr-s4-t1",
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"Germany"
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"id": "DerNervenarzt.00710151.eng.abstr-s4-t2",
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"alexithymia"
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"id": "DerNervenarzt.00710151.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"researchers"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"alexithymia's"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s4-t5",
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"alexithymia's"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s4-t6",
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"role"
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"id": "DerNervenarzt.00710151.eng.abstr-s4-t7",
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"link"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s4-t8",
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"emotion"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s4-t9",
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"disease"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s5-t1",
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"review"
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{
"id": "DerNervenarzt.00710151.eng.abstr-s5-t2",
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"literature"
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"id": "DerNervenarzt.00710151.eng.abstr-s5-t3",
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"id": "DerNervenarzt.00710151.eng.abstr-s5-t4",
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DerNervenarzt.00710164.eng.abstr
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DerNervenarzt.00710164.eng.abstr
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"Children of psychiatrically ill parents represent a risk group that has received growing attention during the last years . The risk for this group to develop a psychiatric illness is markedly increased due to genetic and psychosocial factors . The development of effective preventive concepts requires a thorough knowledge of the psychosocial factors . In this paper , deficits and problems of research in psychosocial transmission mechanisms are discussed taking the example of children of depressive parents . Conclusions from this exemplary considerations may serve as guidelines for future research . The authors suggest that the focus be rather placed on coping strategies and developmental psychopathology . Further , research criteria are formulated that refer to theoretical models as well as to study design ."
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[] |
[] |
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DerNervenarzt.00710181.eng.abstr
|
DerNervenarzt.00710181.eng.abstr
|
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"text": [
"The psycho-scientific diagnosis transposed to legal terms defines and limits the extent of the psychic disturbances that have to be considered in the test of criminal responsibility . The analysis of the criminal act that has to be carried out on this basis is of decisive importance . It must place particular emphasis on the automatic nature of structural orientations and their regulation by deactualization . The psychopathological reference system proposed by Sass can be used to measure the severity of psychic deviance ( \" abnormality \" ) - the different forms its manifestation can take are treated separately in detail - against acute pschoses and against delusion as two basic patterns of psychopathology . If a severe abnormality is confirmed the analysis of the offence that has to be undertaken independently of psychopathological comparisons must be centred on orientations that are contrary to automatically criminal action . These can be respected or overcome by decisions for which the perpetrator can bear the responsibility , or restricted or negated by psychic impairment . Before the author's concluding remarks on the place of such considerations in the enforcement of disciplinary proceedings , some examples of severe psychic abnormality are treated in detail . They are found more frequently in sexual offenders and those involved in drug-related crimes than in other groups of offenders ."
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1414
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]
}
] |
[] |
[] |
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},
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}
] |
DerNervenarzt.00710188.eng.abstr
|
DerNervenarzt.00710188.eng.abstr
|
[
{
"id": "DerNervenarzt.00710188.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Premorbid Adjustment Scale ( PAS ) was developed by Cannon-Spoor et al. 1982 for research use and has gained importance internationally . This scale is designed to measure the extent of attaining developmental goals premorbidly . The German version is presented here , with first data on the reliability and validity of the scale . In a sample of schizophrenic and schizoaffective patients ( n=86) and healthy parents of the patients ( n=38), DSM-IV diagnosis was made and PAS and Positive and Negative Syndrome Scale ( PANSS ) data were taken along with information on the course of the disorder . Using Cronbachs , the estimated reliability for the scale and subscales lay between 0.809 and 0.931. High PAS scores , representing poor premorbid adjustment , correlated significantly with low age of onset , high PANSS scores , insidious onset , long hospitalisation , and serious course of the disorder . The threshold of PAS scores between healthy and sick probands was at 0.23. Patients with scores > 0.53 appeared to have an unfavourable course . With test results > 0.23 , an odds ratio of 27.9 was ascertained ( 95% CI 9.39-M82.89). The findings presented correspond with those from previous reports in literature ."
],
"offsets": [
[
0,
1225
]
]
}
] |
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{
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"Adjustment"
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14,
24
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],
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"db_name": "UMLS",
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Scale"
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25,
30
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"PAS"
],
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[
33,
36
]
],
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{
"db_name": "UMLS",
"db_id": "C0030125"
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s1-t4",
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"research"
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85,
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"use"
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"scale"
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"goals"
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214,
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},
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"scale"
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328,
333
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}
]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"reliability and validity"
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"patients"
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"parents"
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{
"id": "DerNervenarzt.00710188.eng.abstr-s4-t3",
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"patients"
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"id": "DerNervenarzt.00710188.eng.abstr-s4-t4",
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"diagnosis"
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},
{
"id": "DerNervenarzt.00710188.eng.abstr-s4-t5",
"type": "umlsterm",
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"PAS"
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477,
480
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{
"id": "DerNervenarzt.00710188.eng.abstr-s4-t6",
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"Syndrome"
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507,
515
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{
"id": "DerNervenarzt.00710188.eng.abstr-s4-t7",
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{
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t2",
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"PAS"
],
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709,
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t3",
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"adjustment"
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750,
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"age"
],
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[
797,
800
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],
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"db_name": "UMLS",
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},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"hospitalisation"
],
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855,
870
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t6",
"type": "umlsterm",
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"disorder"
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899,
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"age of onset"
],
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797,
809
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],
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s6-t1",
"type": "umlsterm",
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"PAS"
],
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927,
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}
]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"Patients"
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985,
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]
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s7-t1",
"type": "umlsterm",
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]
},
{
"id": "DerNervenarzt.00710188.eng.abstr-s7-t2",
"type": "umlsterm",
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{
"id": "DerNervenarzt.00710188.eng.abstr-s7-t3",
"type": "umlsterm",
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]
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{
"id": "DerNervenarzt.00710188.eng.abstr-s7-t4",
"type": "umlsterm",
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"odds ratio"
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1085,
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}
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[] |
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DerNervenarzt.00710195.eng.abstr
|
DerNervenarzt.00710195.eng.abstr
|
[
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"id": "DerNervenarzt.00710195.eng.abstr-passage-0",
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"text": [
"The present analysis comprises 3 studies on the interrater reliability of the Positive and Negative Syndrome Scale for Schizophrenia ( PANSS ; German version ) . To our knowledge this is the first empirical report on interrater reliability and on results of rater training of the German version of the PANSS despite the widespread use of the scale . In a total of 47 training participants with different clinical experience standardized PANSS rater training was carried out and subsequently evaluated . Therefore , concordance rates with an expert standard ( C ) and weighted coefficients kappa ( w ) were calculated ."
],
"offsets": [
[
0,
618
]
]
}
] |
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}
] |
[] |
[] |
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DerNervenarzt.00710205.eng.abstr
|
DerNervenarzt.00710205.eng.abstr
|
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{
"id": "DerNervenarzt.00710205.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Medical students ' attitudes toward psychiatry are very important for the future care of psychiatric patients and the recruitment of qualified graduates . We examined the attitudes of 105 German medical students toward psychiatry using a German translation of the ATP-30, a reliable , self-administered questionnaire . In spite of a marked interest in psychiatry , most students thought it improbable that they would become psychiatrists . Attitudes toward psychiatry were generally positive ( ATP-30 score : 104.6 +/- 13.4 , where 90 represents middle , or neither positive nor negative ) but showed clear differences in some aspects . Attitudes toward psychotherapy were markedly positive , while those toward psychiatric therapy in general or the scientific basis of psychiatry were less positive . We could find no influence of sex on the ATP score , whereas students having previous experience with psychiatry showed more positive attitudes towards it ."
],
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0,
958
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]
}
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[] |
[] |
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DerNervenarzt.00710213.eng.abstr
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DerNervenarzt.00710213.eng.abstr
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"This paper concerns advances in the integration of psychotherapy in psychiatric education and clinical practice and whether they go along with increasing research activities . To find answers , a survey on psychotherapy research was carried out in all German psychiatric hospitals and departments by means of a questionnaire . The results indicate that psychotherapy research is done nearly exclusively in university hospitals . About half of them had already published psychotherapy studies and two thirds of them are presently carrying out studies , mostly including prospective , randomized clinical trials . These studies cover the whole spectrum of psychiatric disorders : substance abuse , schizophrenic and affective disorders , anxiety , and obsessive compulsive and personality disorders . To improve psychotherapy research conditions further , efforts are necessary to increase scientific exchange , financial support , and the integration of institutions outside the universities ."
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] |
DerNervenarzt.00710218.eng.abstr
|
DerNervenarzt.00710218.eng.abstr
|
[
{
"id": "DerNervenarzt.00710218.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sildenafil ( Viagra ) is a substance for the treatment of erectile dysfunction . Great expectations are connected with its introduction into the market . In this situation the multidimensionality in the control-mechanismus of the sexual reaction and of the satisfaction in the sexual experience are pointed out . These aspects affect the diagnostic and therapeutic competence of psychiatry and psychotherapy in a high degree . Efficient psychoeducative and psychotherapeutic ways of treatment for sexual dysfunction are available . Increased specific knowledge in this area is required by psychiatrists , medical psychotherapists and neuropsychiatrists ."
],
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[
0,
654
]
]
}
] |
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],
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0,
10
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}
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-t2",
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"Viagra"
],
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13,
19
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}
]
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{
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"treatment"
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45,
54
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},
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"dysfunction"
],
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[
67,
78
]
],
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{
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"db_id": "C0031847"
}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"erectile dysfunction"
],
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[
58,
78
]
],
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"db_id": "C0242350"
}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s2-t1",
"type": "umlsterm",
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"market"
],
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145,
151
]
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"satisfaction"
],
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257,
269
]
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}
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"diagnostic"
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338,
348
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-t2",
"type": "umlsterm",
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"therapeutic"
],
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353,
364
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],
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"db_id": "C0039796"
}
]
},
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"id": "DerNervenarzt.00710218.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"competence"
],
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[
365,
375
]
],
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{
"db_name": "UMLS",
"db_id": "C0086035"
}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"psychiatry"
],
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379,
389
]
],
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-t5",
"type": "umlsterm",
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"psychotherapy"
],
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394,
407
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],
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}
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},
{
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483,
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{
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"dysfunction"
],
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504,
515
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],
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{
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-t3",
"type": "umlsterm",
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"sexual dysfunction"
],
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497,
515
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"knowledge"
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551,
560
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],
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{
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}
]
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"psychiatrists"
],
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[
589,
602
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033872"
}
]
}
] |
[] |
[] |
[
{
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{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r2-t1.1-t5.1",
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},
{
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s4-t5",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r4-t5.1-t3.1",
"type": "associated_with",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r5-t1.1-t5.1",
"type": "diagnoses",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r6-t3.1-t1.1",
"type": "uses",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r7-t2.1-t5.1",
"type": "diagnoses",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r8-t3.1-t2.1",
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{
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s1-r10-t2.1-t1.1",
"type": "interacts_with",
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s6-t1",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-r1-t1.1-t3.1",
"type": "method_of",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-r2-t5.1-t3.1",
"type": "method_of",
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-r3-t1.1-t3.1",
"type": "issue_in",
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s5-t3",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-r4-t3.1-t5.1",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s4-r5-t3.1-t1.1",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-r1-t3.2-t1.1",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-r2-t1.1-t3.2",
"type": "degree_of",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-r3-t1.1-t3.2",
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerNervenarzt.00710218.eng.abstr-s5-r4-t3.2-t1.1",
"type": "degree_of",
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},
{
"id": "DerNervenarzt.00710218.eng.abstr-s6-r1-t2.1-t1.1",
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"arg2_id": "DerNervenarzt.00710218.eng.abstr-s6-t1",
"normalized": []
}
] |
DerNervenarzt.00710238.eng.abstr
|
DerNervenarzt.00710238.eng.abstr
|
[
{
"id": "DerNervenarzt.00710238.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cortical dysgenesia are a heterogenous group of genetic or acquired disturbances of cortical development which , due to the enormous progress in modern neuroimaging techniques , are increasingly recognized in association with a variety of clinical disorders . The spectrum of clinical manifestations , depending on type and extent of the alterations , includes severe mental retardation and epilepsy as well as neuropsychological deficits and some psychiatric disorders . Although pathogenesis and pathophysiology of cortical dysgenesis are still not fully understood , the recent discovery of responsible genes , growth factors , neurotransmitters , and exogenous factors sheds light on elementary mechanisms . The development of animal models mimicking different types of human cortical malformations helped to increase further the understanding of functional consequences of focal cortical dysgenesis . Several studies on these models reveal widespread alterations of cortical connectivity and excitability which are probably of crucial importance in different clinical disorders ."
],
"offsets": [
[
0,
1084
]
]
}
] |
[
{
"id": "DerNervenarzt.00710238.eng.abstr-s1-t1",
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"development"
],
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93,
104
]
],
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},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s1-t2",
"type": "umlsterm",
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"techniques"
],
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[
165,
175
]
],
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"db_name": "UMLS",
"db_id": "C0025664"
}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s1-t3",
"type": "umlsterm",
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"association"
],
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209,
220
]
],
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{
"db_name": "UMLS",
"db_id": "C0004083"
}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s1-t4",
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"disorders"
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248,
257
]
],
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}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s2-t1",
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"text": [
"epilepsy"
],
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[
391,
399
]
],
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"db_name": "UMLS",
"db_id": "C0014544"
}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s2-t2",
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"disorders"
],
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460,
469
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mental retardation"
],
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368,
386
]
],
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"db_name": "UMLS",
"db_id": "C0025362"
}
]
},
{
"id": "DerNervenarzt.00710238.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"psychiatric disorders"
],
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448,
469
]
],
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"db_name": "UMLS",
"db_id": "C0004936"
}
]
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] |
DerNervenarzt.00710249.eng.abstr
|
DerNervenarzt.00710249.eng.abstr
|
[
{
"id": "DerNervenarzt.00710249.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Following organ transplantation , 30-60% of patients develop neurologic complications which can be classified as pre-existing deficits due to the underlying disease , complications during surgery , metabolic encephalopathies , neurotoxicity of immunosuppressant agents , opportunistic CNS infections , and secondary malignomas as indirect side effects of immunosuppression . While encephalopathies , seizures , or CNS infection can occur in all types of transplantation , some specific neurological complications exist for different types of organ transplantation . In this review , the clinical symptoms and treatment of both the common neurological complications as well as the particular neurological syndromes after liver , heart , and bone marrow transplantation are discussed ."
],
"offsets": [
[
0,
783
]
]
}
] |
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] |
[] |
[] |
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{
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},
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},
{
"id": "DerNervenarzt.00710249.eng.abstr-s3-r27-t1.1-t2.1",
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{
"id": "DerNervenarzt.00710249.eng.abstr-s3-r28-t4.1-t10.2",
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}
] |
DerNervenarzt.00710265.eng.abstr
|
DerNervenarzt.00710265.eng.abstr
|
[
{
"id": "DerNervenarzt.00710265.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a meta-analysis of 69 prospective and retrospective studies , we investigated the value of various surgical techniques in the treatment of lumbar disk herniations ."
],
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[
0,
167
]
]
}
] |
[
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-t1",
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"meta-analysis"
],
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5,
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],
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}
]
},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-t2",
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41,
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"id": "DerNervenarzt.00710265.eng.abstr-s1-t3",
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"value"
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85,
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}
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"id": "DerNervenarzt.00710265.eng.abstr-s1-t4",
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"surgical"
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[
102,
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{
"id": "DerNervenarzt.00710265.eng.abstr-s1-t5",
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"techniques"
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111,
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"id": "DerNervenarzt.00710265.eng.abstr-s1-t6",
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"treatment"
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129,
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}
]
},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-t7",
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"retrospective studies"
],
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[
41,
62
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035363"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r1-t3.1-t6.1",
"type": "evaluation_of",
"arg1_id": "DerNervenarzt.00710265.eng.abstr-s1-t3",
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{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r2-t2.1-t3.1",
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},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r3-t3.1-t6.1",
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"arg2_id": "DerNervenarzt.00710265.eng.abstr-s1-t6",
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},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r4-t1.1-t3.1",
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},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r5-t3.1-t1.1",
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},
{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r6-t1.1-t2.1",
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{
"id": "DerNervenarzt.00710265.eng.abstr-s1-r7-t2.1-t6.1",
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"arg2_id": "DerNervenarzt.00710265.eng.abstr-s1-t6",
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] |
DerNervenarzt.00710275.eng.abstr
|
DerNervenarzt.00710275.eng.abstr
|
[
{
"id": "DerNervenarzt.00710275.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 45 patients with Parkinson's disease , we investigated coping behavior and its correlations to demographic and disease-related data , locus of control , depression , and psychosocial adaptation . Active , problem oriented , and self-reorganizing strategies were predominantly used and regarded as especially helpful by the 27 men and 18 women ( age : 56 years ; duration of illness : 9 years ) . While age and sex were not associated with coping , external locus of control correlated positively to \" depressive coping \" and duration of illness correlated negatively to \" distraction and self-affirmation . \" Coping strategies regarded as maladaptive and a small degree of internal locus of control correlated to unfavourable results for depression and satisfaction ."
],
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[
0,
770
]
]
}
] |
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t1",
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"id": "DerNervenarzt.00710275.eng.abstr-s1-t2",
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32,
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t3",
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"behavior"
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65,
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"db_name": "UMLS",
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t4",
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114,
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],
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"id": "DerNervenarzt.00710275.eng.abstr-s1-t5",
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"control"
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146,
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]
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"db_name": "UMLS",
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t6",
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"depression"
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156,
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"db_name": "UMLS",
"db_id": "C0011570"
}
]
},
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"adaptation"
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186,
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-t8",
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58,
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"id": "DerNervenarzt.00710275.eng.abstr-s1-t9",
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137,
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],
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{
"id": "DerNervenarzt.00710275.eng.abstr-s2-t1",
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329,
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],
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"db_name": "UMLS",
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"db_name": "UMLS",
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{
"id": "DerNervenarzt.00710275.eng.abstr-s2-t2",
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"text": [
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340,
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"id": "DerNervenarzt.00710275.eng.abstr-s2-t3",
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"db_name": "UMLS",
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]
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{
"id": "DerNervenarzt.00710275.eng.abstr-s3-t1",
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405,
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710275.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
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413,
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"db_name": "UMLS",
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]
},
{
"id": "DerNervenarzt.00710275.eng.abstr-s3-t3",
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469,
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]
},
{
"id": "DerNervenarzt.00710275.eng.abstr-s3-t4",
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591,
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"id": "DerNervenarzt.00710275.eng.abstr-s3-t5",
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460,
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"id": "DerNervenarzt.00710275.eng.abstr-s4-t1",
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694,
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}
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s4-t2",
"type": "umlsterm",
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741,
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
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756,
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s4-t4",
"type": "umlsterm",
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685,
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023953"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r1-t9.1-t8.1",
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"id": "DerNervenarzt.00710275.eng.abstr-s1-r7-t2.1-t7.1",
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r10-t8.1-t1.1",
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"id": "DerNervenarzt.00710275.eng.abstr-s1-r11-t3.1-t5.1",
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r12-t4.1-t1.1",
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r13-t3.1-t4.1",
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{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r14-t7.1-t5.1",
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"id": "DerNervenarzt.00710275.eng.abstr-s1-r15-t4.1-t7.1",
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},
{
"id": "DerNervenarzt.00710275.eng.abstr-s1-r16-t4.1-t8.1",
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{
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DerNervenarzt.00710282.eng.abstr
|
DerNervenarzt.00710282.eng.abstr
|
[
{
"id": "DerNervenarzt.00710282.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The preoperative localization of pharmaco-resistent focal epilepsies before surgery and the prognosis concerning seizure outcome are both of importance . In addition to conventional MRI diagnostics for the detection of small epileptogenic lesions , proton magnetic resonance spectroscopic imaging ( HMR spectroscopy ) can be useful for assessing the bilaterality of pathological changes in cryptogenic temporal lobe epilepsies . The technique and findings of HMR spectroscopy are reported in patients with cryptogenic temporal lobe epilepsies . The findings indicate that chemical shift imaging ( CSI ) investigations of the ipsilateral and contralateral hemispheres provide important information for the prediction of seizure outcome after epilepsy surgery ."
],
"offsets": [
[
0,
759
]
]
}
] |
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DerNervenarzt.00710288.eng.abstr
|
DerNervenarzt.00710288.eng.abstr
|
[
{
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"type": "abstract",
"text": [
"For determining the prevalence of multiple sclerosis ( MS ) in Germany , the outcomes of several epidemiological studies are available . If these rates are transferred to Germany as a whole , figures result of 67,000 to 138,000 MS patients in all . The differing prevalence rates may be caused by various problems in finding patients , the epidemiological area , and different population structures . To avoid these difficulties , a new approach for calculating the number of patients with diagnosed MS was chosen based on representative samples taken from the groups of physicians involved in MS treatment . The disadvantage of this approach is that it does not allow any questioning of the diagnosis . Projecting the results in this way and their subsequent compilation - taking \" double treatments \" into consideration - showed a total of 122,000 patients with diagnosed multiple sclerosis in Germany . This figure corresponds to a prevalence rate of 149.1 per 100,000 inhabitants and is within the range found by Poser et al. [ 19 ] : 127 per 100,000 excluding the diagnostic category \" possible multiple sclerosis \" and 170 per 100,000 including it ."
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DerNervenarzt.00710295.eng.abstr
|
DerNervenarzt.00710295.eng.abstr
|
[
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"type": "abstract",
"text": [
"Paraneoplastic neurological syndromes are rare diseases that occur in relation to cancer . Supporting the hypothesis of an autoimmune mechanism , specific antineuronal antibodies have sometimes been detected . The current possibilities for treatment are limited . A female patient , aged 57 , suffering from a breast cancer , developed a severe paraneoplastic cerebellar syndrome and limbic encephalitis within a few weeks . It is possible that the impressive partial remission that occurred during the ensuing 6 months was not due to therapy . Although the patient was still bound to a wheelchair , discharge from hospital was possible because she was still able to perform daily tasks by herself . A recurrence of the cerebellar symptoms with mild alterations of mental status occurred 2 months later but again showed a good remission ."
],
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[
0,
838
]
]
}
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[] |
[] |
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DerNervenarzt.00710299.eng.abstr
|
DerNervenarzt.00710299.eng.abstr
|
[
{
"id": "DerNervenarzt.00710299.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In Crohn's disease , some concomitant neurological illnesses such as cerebral ischemia following arterial or venous thrombosis , subacute combined degeneration of the spinal cord following malabsorption of vitamin B12 or folic acid , opticus neuropathy , and polyneuropathy have been described . Cerebral vasculitis secondary to Crohn's disease seems to be a very rare phenomenon . We report on three such cases in three female patients ( aged 26 , 29 , and 61 years ) . All patients became symptomatic with a hemiparesis ; one complained additionally of a speech disorder , headache , and intermittent loss of orientation . In CT and MRI scans , multiple lesions were detected ; cerebral angiography showed multiple stenoses of middle- and large-sized vessels that were compatible with cerebral vasculitis . Serologic tests concerning vasculitis were inconspicuous at that time . Under anticoagulation ( in two cases ) and immunosuppressive therapy , neurologic symptoms disappeared . In the following 6 to 12 months , no new neurological symptoms appeared . In two cases , Doppler sonographic controls showed stationary and , in one case , progressive intracranial stenoses ."
],
"offsets": [
[
0,
1177
]
]
}
] |
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{
"id": "DerNervenarzt.00710299.eng.abstr-s1-t2",
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"ischemia"
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{
"id": "DerNervenarzt.00710299.eng.abstr-s1-t3",
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"thrombosis"
],
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116,
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{
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"malabsorption"
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"vitamin"
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"acid"
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"opticus"
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{
"id": "DerNervenarzt.00710299.eng.abstr-s1-t9",
"type": "umlsterm",
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{
"id": "DerNervenarzt.00710299.eng.abstr-s1-t10",
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DerNervenarzt.00710305.eng.abstr
|
DerNervenarzt.00710305.eng.abstr
|
[
{
"id": "DerNervenarzt.00710305.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In recent years , the frequency of primary cerebral lymphoma ( PCNSL ) has increased , even among immunocompetent patients . In order to treat the disease optimally , early diagnosis is important . We present three patients with atypical courses of this disease and stress the importance of PCNSL in the differential diagnosis for optimal treatment . In a 75-year-old man , a space-occupying , radiopaque , enhancing CNS lesion disappeared completely after biopsy and short steroid therapy . One year later , the tumor recurred on the other side and again regressed after steroid therapy . The first biopsy showed signs of a papillary tumor , so a choroid plexus papilloma was suspected initially . A 57-year-old woman developed progressive bilateral hearing dysfunction . Lymphocytic pleocytosis led to a primary diagnosis of chronic lymphocytic meningitis . During the further course of disease , the patient developed multiple space-occupying cerebral lesions . Stereotactic biopsy revealed PCNSL . Despite combined chemo- and radiotherapy , a relapse occurred . A 49-year-old woman rapidly developed memory and concentration disturbances . Computed tomography revealed diffuse edema in both hemispheres and MRI detected severe , diffuse , white matter lesions . The CSF revealed lymphocytic pleocytosis including plasma cells . Herpes encephalitis and , after lack of clinical improvement and progression of the MRI changes , acute disseminated encephalomyelitis ( ADEM ) were suspected . Cortocosteroid treatment was initiated . After enormous clinical improvement , a clinical relapse occurred and MRI detected bitemporal and singular space-occupying lesions in the corpus callosum and hypothalamus . Finally , open biopsy showed PCNSL ."
],
"offsets": [
[
0,
1743
]
]
}
] |
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] |
[] |
[] |
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DerNervenarzt.00710316.eng.abstr
|
DerNervenarzt.00710316.eng.abstr
|
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{
"id": "DerNervenarzt.00710316.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 30-year-old patient with isolated , left-sided hypoglossal nerve palsy after uncomplicated , presumably streptococci-induced tonsillitis . Needle electromyography ( EMG ) of the tongue showed denervation changes in the muscles supplied by the left hypoglossal nerve . Cranial CT and MRI , CSF examination , Doppler sonography , visual evoked potential ( VEP ) , and auditory evoked potential ( AEP ) showed no abnormalities and , in particular , no signs of the carotid artery dissection or brainstem lesion . The symptoms and signs resolved within a few weeks after penicillin V treatment . We suppose that the hypoglossal affection of the uncomplicated tonsillitis in this case was due to an aberrant position of the nerve ."
],
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[
0,
741
]
]
}
] |
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DerNervenarzt.00710354.eng.abstr
|
DerNervenarzt.00710354.eng.abstr
|
[
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"id": "DerNervenarzt.00710354.eng.abstr-passage-0",
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"text": [
"31Phosphorus nuclear magnetic resonance spectroscopy ( 31P-MRS) has gained much interest in schizophrenia research in the last years , since it allows noninvasive measurement of high energy phosphates and phospholipids of the human brain in vivo . Thus , several studies have reported cerebral metabolic differences between patients and healthy controls as well as on lateralization effects and influences of epidemiological and psychopathological factors . This review gives a survey of the potential of 31P-MRS in schizophrenia research and summarizes and comments on the results of preceding studies . The discussion covers the reduction of phospholipids in patients in the context of the membrane phospholipid hypotheses , the question of an energetic hypometabolism in schizophrenics , and the influence of neuroleptic medication ."
],
"offsets": [
[
0,
836
]
]
}
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DerNervenarzt.00710364.eng.abstr
|
DerNervenarzt.00710364.eng.abstr
|
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571
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[] |
[] |
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DerNervenarzt.00710373.eng.abstr
|
DerNervenarzt.00710373.eng.abstr
|
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"id": "DerNervenarzt.00710373.eng.abstr-passage-0",
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"Beside the typical extrapyramidal motor symptoms such as rigidity , tremor , and dyskinesia , a reduction in handwriting area may occur under neuroleptic therapy . To date , the nature of the relationship between a reduction in handwriting area and striatal D2 dopamine receptor occupancy has remained unclear , and it is not known whether such a reduction also occurs under treatment with atypical neuroleptic drugs . In 23 schizophrenic patients treated with haloperidol , haloperidol decanoate , risperidone , and clozapine , the handwriting area was examined using a planimetric computer program . 123I-iodobenzamide ( IBZM ) single photon emission tomography ( SPET ) was used to measure the D2 dopamine receptor occupancy . A statistically significant correlation was found between a reduction in handwriting area and D2 dopamine receptor occupancy ( r=0.86; P 0.0001 ) . The curve derived from the plotted data resulted in a hyperbolic function . The regression was present regardless of whether the patients were treated with typical or atypical neuroleptic drugs ."
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0,
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[] |
[] |
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] |
DerNervenarzt.00710380.eng.abstr
|
DerNervenarzt.00710380.eng.abstr
|
[
{
"id": "DerNervenarzt.00710380.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Up to now there are no published results of therapy of paraphilia ( Pedophilia , Sadism ) and sexual aggressive impulsiveness with LHRH- ( luteinizing hormone-releasing hormone ) Agonists in the Germanspeaking countries . In this report we describe 11 patients which were treated with the LHRH-Agonist Leuprolide Acetate in a period of 12 months . The patients showed no tendency of sexuell aggressive behaviour and reported an evident reduction of penile erection , ejaculation , masturbation , sexual deviant impulsiveness and phantasies . One patient died from suicide . In combination with other treatments LHRH-Agonist seem to be a very promising alternative to cyproterone acetate and its possible carcinogene effects ."
],
"offsets": [
[
0,
725
]
]
}
] |
[
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"id": "DerNervenarzt.00710380.eng.abstr-s1-t1",
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"therapy"
],
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44,
51
]
],
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"db_id": "C0039798"
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]
},
{
"id": "DerNervenarzt.00710380.eng.abstr-s1-t2",
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"paraphilia"
],
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55,
65
]
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}
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},
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"id": "DerNervenarzt.00710380.eng.abstr-s1-t3",
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"text": [
"Pedophilia"
],
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68,
78
]
],
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"db_id": "C0030764"
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s1-t4",
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"text": [
"Sadism"
],
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]
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],
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],
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},
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"id": "DerNervenarzt.00710380.eng.abstr-s1-t7",
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],
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"patients"
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260
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},
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"id": "DerNervenarzt.00710380.eng.abstr-s2-t2",
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"text": [
"Leuprolide"
],
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302,
312
]
],
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"db_id": "C0085272"
}
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"Acetate"
],
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313,
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]
],
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"Leuprolide Acetate"
],
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320
]
],
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t1",
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"text": [
"patients"
],
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]
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"normalized": [
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"behaviour"
],
"offsets": [
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402,
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]
],
"normalized": [
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"db_id": "C0004927"
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t3",
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"text": [
"erection"
],
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456,
464
]
],
"normalized": [
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"ejaculation"
],
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467,
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
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],
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481,
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t6",
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"text": [
"aggressive behaviour"
],
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]
],
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"db_id": "C0001807"
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},
{
"id": "DerNervenarzt.00710380.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
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],
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DerNervenarzt.00710386.eng.abstr
|
DerNervenarzt.00710386.eng.abstr
|
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"id": "DerNervenarzt.00710386.eng.abstr-passage-0",
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"In a polydiagnostic study , a systematically recruited collective of 34 women with a first-episode postpartum psychosis was reexamined after a period of 6-26 years ( averaging 12.6 years ) in order to establish lifetime-diagnoses according to ICD-10 and Leonhard's classification , and to determine course and outcome . According to ICD-10, unipolar depressive disorders ( 32% ) and acute polymorphous psychotic disorders ( 28% ) represented the most frequent diagnoses . Applying Leonhard's classification revealed a marked predominance of cycloid psychoses ( 62% ) with the subform of motility psychosis being the most frequent diagnosis ( 38% ) . Schizophrenias occurred rarely according to both classifications ."
],
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[
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716
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]
}
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"id": "DerNervenarzt.00710386.eng.abstr-s1-t4",
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"psychosis"
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"id": "DerNervenarzt.00710386.eng.abstr-s1-t6",
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"id": "DerNervenarzt.00710386.eng.abstr-s2-t2",
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[] |
[] |
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DerNervenarzt.00710393.eng.abstr
|
DerNervenarzt.00710393.eng.abstr
|
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{
"id": "DerNervenarzt.00710393.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The present study examines episode characteristics in unipolar psychotic depression . From a sample of unipolar endogenous depressed inpatients , patients with a psychotic index episode ( n=19) were compared to nonpsychotic patients ( n=86) with regard to case history , characteristics of the inpatient episode , residual symptoms at discharge from hospital and course of illness up to seven months after discharge . Psychotic depressed patients displayed more severe observer-rated depressive symptoms at admission and were more likely to have attempted suicide prior to admission . In the post-discharge short-term course of depression , these patients showed a more pronounced symptom homogeneity in the extreme ranges , which occurred by stable remissions or by prolonged symptomatology in need of treatment . These findings , together with the observation of higher stabilities of symptom scores in the psychotically depressed , emphasize the prognostic significance of symptomatology at discharge to the post-discharge episode course in these patients ."
],
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0,
1060
]
]
}
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[] |
[] |
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DerNervenarzt.00710401.eng.abstr
|
DerNervenarzt.00710401.eng.abstr
|
[
{
"id": "DerNervenarzt.00710401.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 28-year-old patient with a 5-year history of bipolar disorder developed signs of encephalopathy 2 weeks after the addition of valproic acid to his treatment regimen of doxepine , risperidone , and biperidene . The clinical signs were drowsiness , ataxic gait , asterixis , and a generalized epileptic seizure . Discontinuation of valproic acid gradually resulted in complete remission of these symptoms . Valproate encephalopathy has been described mainly in patients receiving anticonvulsant polytherapy . This complication might become more prevalent in psychiatric pharmacotherapy due to the increasing use of valproic acid ."
],
"offsets": [
[
0,
630
]
]
}
] |
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DerNervenarzt.00710404.eng.abstr
|
DerNervenarzt.00710404.eng.abstr
|
[
{
"id": "DerNervenarzt.00710404.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made ."
],
"offsets": [
[
0,
949
]
]
}
] |
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"arg2_id": "DerNervenarzt.00710404.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerNervenarzt.00710404.eng.abstr-s4-r30-t6.1-t3.3",
"type": "associated_with",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s4-t6",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerNervenarzt.00710404.eng.abstr-s4-r31-t3.1-t1.1",
"type": "location_of",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s5-t3",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerNervenarzt.00710404.eng.abstr-s4-r32-t1.2-t8.1",
"type": "produces",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s4-t1",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s4-t8",
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},
{
"id": "DerNervenarzt.00710404.eng.abstr-s4-r33-t6.1-t8.1",
"type": "measures",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s4-t6",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s4-t8",
"normalized": []
},
{
"id": "DerNervenarzt.00710404.eng.abstr-s4-r34-t8.1-t3.1",
"type": "causes",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s4-t8",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s5-t3",
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},
{
"id": "DerNervenarzt.00710404.eng.abstr-s5-r2-t2.1-t3.1",
"type": "performs",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s5-t2",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s5-t3",
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},
{
"id": "DerNervenarzt.00710404.eng.abstr-s5-r3-t2.1-t3.1",
"type": "uses",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s5-t2",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s5-t3",
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},
{
"id": "DerNervenarzt.00710404.eng.abstr-s5-r4-t2.1-t3.2",
"type": "uses",
"arg1_id": "DerNervenarzt.00710404.eng.abstr-s5-t2",
"arg2_id": "DerNervenarzt.00710404.eng.abstr-s5-t3",
"normalized": []
}
] |
DerNervenarzt.00710420.eng.abstr
|
DerNervenarzt.00710420.eng.abstr
|
[
{
"id": "DerNervenarzt.00710420.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The situation of psychiatric patients in the Ukraine is determined by the financial and economic difficulties of this country . In the larger cities , so-called polyclinics take care of ambulant psychiatric patients . However , no other social psychiatric institutions exist . Here , the modalities of hospital psychiatric treatment are discussed using the psychiatric hospitals in Kiev and Shitomir as examples . Undertreatment is also a problem , because only a few psychopharmacological drugs are produced in the Ukraine . Import of new psychopharmacological agents is hampered by economical problems . Improving the availability of psychopharmacological drugs and the establishment of a social psychiatric network are major aims for psychiatrists working in Ukraine ."
],
"offsets": [
[
0,
771
]
]
}
] |
[
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-t1",
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"text": [
"patients"
],
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[
29,
37
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Ukraine"
],
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[
45,
52
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041580"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"financial"
],
"offsets": [
[
74,
83
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376243"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"economic"
],
"offsets": [
[
88,
96
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013557"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"cities"
],
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[
142,
148
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0008848"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"care"
],
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[
178,
182
]
],
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"db_id": "C0150499"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
207,
215
]
],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"hospital"
],
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[
302,
310
]
],
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"db_name": "UMLS",
"db_id": "C0019994"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"treatment"
],
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[
323,
332
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"hospitals"
],
"offsets": [
[
369,
378
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019994"
}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"psychiatric hospitals"
],
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[
357,
378
]
],
"normalized": [
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}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"drugs"
],
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490,
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]
],
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}
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},
{
"id": "DerNervenarzt.00710420.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"Ukraine"
],
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516,
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]
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"id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"drugs"
],
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658,
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]
],
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}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"aims"
],
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}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"psychiatrists"
],
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737,
750
]
],
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}
]
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
"Ukraine"
],
"offsets": [
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762,
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]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0041580"
}
]
}
] |
[] |
[] |
[
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-r1-t3.1-t2.1",
"type": "measurement_of",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t3",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s1-r2-t4.1-t2.1",
"type": "measurement_of",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t4",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s2-r1-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s2-r2-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-r1-t1.1-t2.1",
"type": "carries_out",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-r2-t2.1-t1.1",
"type": "uses",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-r3-t2.1-t4.1",
"type": "uses",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t4",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s4-r4-t4.1-t2.1",
"type": "carries_out",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t4",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s7-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerNervenarzt.00710420.eng.abstr-s7-r2-t2.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerNervenarzt.00710420.eng.abstr-s7-t2",
"arg2_id": "DerNervenarzt.00710420.eng.abstr-s7-t1",
"normalized": []
}
] |
DerNervenarzt.00710431.eng.abstr
|
DerNervenarzt.00710431.eng.abstr
|
[
{
"id": "DerNervenarzt.00710431.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To date , at least 12 types of primary dystonia can be distinguished on a genetic basis . A 3-bp deletion in the DYT1 gene causes early onset , generalized torsion dystonia ( TD ) , and mutations in the GTP cyclohydrolase I and the tyrosine hydroxylase genes result in dopa-responsive dystonia ( DYT5). A missense change in the D2 dopamine receptor in one large family ( DYT11) has recently been implicated in myoclonus-dystonia . Furthermore , seven other loci for dystonia genes have been mapped to chromosomal regions , including a locus for a mixed dystonia phenotype ( DYT6), one form of focal dystonia ( DYT7), three types of paroxysmal dystonia ( DYT8-10), X-linked dystonia-parkinsonism ( DYT3), and rapid-onset dystonia-parkinsonism ( DYT12). No positive linkage results have yet been obtained for autosomal recessive TD ( DYT2) and several other families of different types of dominantly inherited TD ( DYT4). In addition , hereditary secondary dystonia may occur as part of familial diseases of the basal ganglia , metabolic and storage disorders , and various X-linked and other familial neurodegenerative syndromes affecting the basal ganglia . It may be anticipated that the traditional clinical and etiological classifications of dystonia will increasingly be replaced by a genetic one and that the identification of more dystonia genes may lead to a better understanding of these largely nondegenerative disorders ."
],
"offsets": [
[
0,
1431
]
]
}
] |
[
{
"id": "DerNervenarzt.00710431.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"date"
],
"offsets": [
[
3,
7
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011008"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"dystonia"
],
"offsets": [
[
39,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013421"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"gene"
],
"offsets": [
[
118,
122
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017337"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"torsion"
],
"offsets": [
[
156,
163
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040480"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"dystonia"
],
"offsets": [
[
164,
172
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013421"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"mutations"
],
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[
186,
195
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026882"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"GTP"
],
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[
203,
206
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018353"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"tyrosine"
],
"offsets": [
[
232,
240
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041485"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"hydroxylase"
],
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[
241,
252
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020364"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"genes"
],
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[
253,
258
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017337"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"dopa-responsive"
],
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[
269,
284
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013023"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"dystonia"
],
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[
285,
293
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013421"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"dopamine"
],
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[
331,
339
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013030"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"family"
],
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[
362,
368
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015576"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t13",
"type": "umlsterm",
"text": [
"torsion dystonia"
],
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[
156,
172
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013423"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t14",
"type": "umlsterm",
"text": [
"GTP cyclohydrolase"
],
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[
203,
221
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018293"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t15",
"type": "umlsterm",
"text": [
"tyrosine hydroxylase"
],
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[
232,
252
]
],
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{
"db_name": "UMLS",
"db_id": "C0041491"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t16",
"type": "umlsterm",
"text": [
"dopamine receptor"
],
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[
331,
348
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034798"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s2-t17",
"type": "umlsterm",
"text": [
"GTP cyclohydrolase I"
],
"offsets": [
[
203,
223
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205775"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"dystonia"
],
"offsets": [
[
466,
474
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013421"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"genes"
],
"offsets": [
[
475,
480
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017337"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"dystonia"
],
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[
553,
561
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013421"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"form"
],
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[
585,
589
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerNervenarzt.00710431.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"dystonia"
],
"offsets": [
[
599,
607
]
],
"normalized": [
{
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] |
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