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DerHautarzt.80490310.eng.abstr
|
DerHautarzt.80490310.eng.abstr
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[
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"id": "DerHautarzt.80490310.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Interferon alpha and gamma have been used to treat several hepatic , hematological and oncological diseases for years . Recently , interferon beta has been introduced as a therapeutic agent in relapsing-remitting multiple sclerosis . A 41-year-old female patient with multiple sclerosis developed non-tender , palm-sized , cutaneous-subcutaneous , reddish infiltrates at the injection sites on her thighs after 8 weeks of treatment with subcutaneous interferon beta injections . Histopathology revealed a perivascular lymphoid infiltrate of the dermis and a subtle lobular lymphoid infiltrate of the subcutis . Interferon beta therapy was discontinued for 4 weeks . With topical corticosteroids , the skin lesions resolved . When subcutaneous injections were resumed at a reduced dose , only erythema around injection sites developed without induration or pain . Slight erythema and swelling at interferon beta injection site are frequent and rare cases of cutaneous necrosis have been described . However , no reports of large , painful , cutaneous-subcutaneous infiltrates after interferon beta therapy have been published ."
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] |
[] |
[] |
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DerHautarzt.80490313.eng.abstr
|
DerHautarzt.80490313.eng.abstr
|
[
{
"id": "DerHautarzt.80490313.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 55-year-old man with CREST syndrome had marked telangiectasias of the palms , the face and the gastrointestinal tract . The latter caused slow bleeding and anemia . The telangiectasias were definitely associated with the CREST syndrome . Iron substitution was sufficient therapy . If a need for further therapy should arise , endoscopic sclerotherapy could be employed . Gastrointestinal bleeding in the CREST syndrome is rarely described , probably because it is unrecognized or interpreted as hemorrhagic gastritis . The possibility of gastrointestinal telangiectasias and concomitant bleeding should be kept in mind in cases of CREST syndrome ."
],
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[
0,
649
]
]
}
] |
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{
"id": "DerHautarzt.80490313.eng.abstr-s1-t2",
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[] |
[] |
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DerHautarzt.80490317.eng.abstr
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DerHautarzt.80490317.eng.abstr
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DerHautarzt.80490351.eng.abstr
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DerHautarzt.80490351.eng.abstr
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DerHautarzt.80490367.eng.abstr
|
DerHautarzt.80490367.eng.abstr
|
[
{
"id": "DerHautarzt.80490367.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We compared a cw carbon dioxide flash-scanning laser system to an Er : YAG laser in laser skin resurfacing of facial rhytides . In all patients , CO2 laser treatment showed a better cosmetic result whereas erythema and postinflammatory hyperpigmentation were less marked in Er : YAG laser therapy ."
],
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[
0,
298
]
]
}
] |
[
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},
{
"id": "DerHautarzt.80490367.eng.abstr-s2-t5",
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{
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}
]
}
] |
[] |
[] |
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "DerHautarzt.80490367.eng.abstr-s2-r17-t1.1-t4.1",
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},
{
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},
{
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},
{
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{
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},
{
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},
{
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}
] |
DerHautarzt.80490372.eng.abstr
|
DerHautarzt.80490372.eng.abstr
|
[
{
"id": "DerHautarzt.80490372.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Across the boundaries of the medical specialties we have realized how important the concepts of quality of life and disease-related coping behavior are to understand the patients ' subjective perception of the medical condition and its treatment . Although standardized instruments are already available for different medical indications and even in the related fields of peripheral vascular and cardiac diseases , phlebology still lacks standardized concepts for evaluating quality of life and/or disease-related coping behavior in patients with chronic venous insufficiency ( CVI ) . We report on a newly developed instrument specifically designed for recording quality of life in patients with CVI . It not only meets the requirements of psychometric standards , but has also proven its applicability in clinical use . The \" Tuebingen Questionnaire for measuring Quality of Life in patients with CVI ( TLQ-CVI ) \" and the results of a study on quality of life in 142 patients with various stages of chronic venous insufficiency are presented . It was possible to distinguish between Stage I/II and Stage III CVI patients with respect to parameters such as \" leg complaints \" and \" day-to-day fears and worries \" . These convey clinically relevant insights into the patient's subjective perception of the disease and how they cope . The information gathered provides a set of reasonable target scores for clinical studies presently being carried out at various study centers in Germany incorporating the TLQ-CVI ."
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[] |
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] |
DerHautarzt.80490382.eng.abstr
|
DerHautarzt.80490382.eng.abstr
|
[
{
"id": "DerHautarzt.80490382.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Gynecomastia is an enlargement of the male breast . We studied a group of 115 men attending a dermatological clinic to evaluate the frequency of possible risk factors and hormonal findings . Gynecomastia was diagnosed , if a horizontal skinfold exceeded 2-3 cm , and if the diameter of the areola wa greater than 3 cm . In 32 patients ( 27,8% ) the criteria for gynecomastia were fulfilled . The frequency increased significantly with the body mass index . 18 different medications were identified , but only two were take by more than two patients ( allopurinol , coronary dilators ) . None of the 15 underlying diseases was associated with a significant increase or decrease in the risk of gynecomastia . Serum cortisol was the only endocrine study which was associated with an increased incidence of gynecomastia . As gynecomastia appears frequently as a phenomenon unrelated to other diseases or medications , it may be a condition per se ."
],
"offsets": [
[
0,
944
]
]
}
] |
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12
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{
"id": "DerHautarzt.80490382.eng.abstr-s1-t2",
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"enlargement"
],
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{
"id": "DerHautarzt.80490382.eng.abstr-s1-t3",
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"male"
],
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"id": "DerHautarzt.80490382.eng.abstr-s1-t4",
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"breast"
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}
]
},
{
"id": "DerHautarzt.80490382.eng.abstr-s2-t1",
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"men"
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"risk"
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"findings"
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180,
188
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}
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{
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"risk factors"
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},
{
"id": "DerHautarzt.80490382.eng.abstr-s3-t1",
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"Gynecomastia"
],
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203
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}
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},
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"id": "DerHautarzt.80490382.eng.abstr-s4-t2",
"type": "umlsterm",
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"criteria"
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},
{
"id": "DerHautarzt.80490382.eng.abstr-s4-t3",
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{
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{
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}
] |
[] |
[] |
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DerHautarzt.80490388.eng.abstr
|
DerHautarzt.80490388.eng.abstr
|
[
{
"id": "DerHautarzt.80490388.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 68-year old woman presented with a frontal fibrosing alopecia and lesions of the buccal mucous membranes typical for lichen planus . Postmenopausal frontal fibrosing alopecia ( PFFA ) has recently been described by Kossard as a distinct entity characterized by progressive recession of the frontotemporal and parietal hair margins leading to permanent alopecia in the form of a symmetrical band-like area of scarring in postmenopausal women . The histology ( perifollicular lymphocytic infiltration and fibrosis , increase of apoptosis of hair follicle keratinocytes ) is indistinguishable from that of lichen planopilaris . The localization and age- and sex-related characteristics of PFFA are not sufficient to delineate it as a discrete entity from lichen planopilaris . Our observation of oral lichen planus in a postmenopausal woman with frontal fibrosing alopecia points to the possibility that PFFA actually may represent a variant of lichen planopilaris with a predilection for the frontotemporal hairline . Other variants of lichen planopilaris include multifocal lichen planopilaris , disseminated lichen planopilaris ( Lassueur-Graham-Little syndrome ) , lichenoid pseudopelade , and any combination of these ( \" mixed type \" ) . An effective therapy of PFFA is not known . Also , treatment of lichen planopilaris forms in which fibrosis predominates over inflammation is similarly problematic , but the natural course of these diseases seems to be self-limited ."
],
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0,
1476
]
]
}
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] |
DerHautarzt.80490392.eng.abstr
|
DerHautarzt.80490392.eng.abstr
|
[
{
"id": "DerHautarzt.80490392.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sinus histiocytosis is as a rule a benign disease of lymph nodes , infiltrated by large histiocytes . These cells show typical cytophagocytosis , particularly lymphophagocytosis . Other organs may be also involved by this disease , often including the skin . Exclusive cutaneous sinus histiocytosis without infiltration of lymph nodes seems to be very rare . To exclude other non-X histiocytoses or histiocytosis-X , it is advisable to use immunohistochemistry . We report on a patient with sinus histiocytosis and discuss the problems of differential diagnosis ."
],
"offsets": [
[
0,
563
]
]
}
] |
[
{
"id": "DerHautarzt.80490392.eng.abstr-s1-t1",
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"Sinus"
],
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[
0,
5
]
],
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"db_id": "C0030471"
}
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s1-t2",
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"text": [
"disease"
],
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.80490392.eng.abstr-s1-t3",
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"lymph"
],
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[
53,
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]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490392.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"histiocytes"
],
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[
88,
99
]
],
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"db_id": "C0019612"
}
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},
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"id": "DerHautarzt.80490392.eng.abstr-s1-t5",
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"Sinus histiocytosis"
],
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[
0,
19
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}
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s1-t6",
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"lymph nodes"
],
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[
53,
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],
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{
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}
]
},
{
"id": "DerHautarzt.80490392.eng.abstr-s2-t1",
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"text": [
"cells"
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108,
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]
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"id": "DerHautarzt.80490392.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s3-t2",
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}
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s4-t1",
"type": "umlsterm",
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"sinus"
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[
279,
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]
],
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}
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s4-t2",
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"text": [
"lymph"
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328
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s4-t3",
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"text": [
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279,
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],
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s4-t4",
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"lymph nodes"
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323,
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s5-t1",
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}
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},
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"id": "DerHautarzt.80490392.eng.abstr-s6-t1",
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],
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s6-t2",
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"sinus"
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]
},
{
"id": "DerHautarzt.80490392.eng.abstr-s6-t3",
"type": "umlsterm",
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{
"id": "DerHautarzt.80490392.eng.abstr-s6-t4",
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},
{
"id": "DerHautarzt.80490392.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
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"db_id": "C0220820"
},
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"db_id": "C0011906"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.80490403.eng.abstr
|
DerHautarzt.80490403.eng.abstr
|
[
{
"id": "DerHautarzt.80490403.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 44-year-old male patient with lupuserythematosus profundus ( lupus panniculitis ) ( LEP ) of the right cheek/infraorbital region presented as a recurrent swelling . He had only anti-neutrophil-cytoplasmic antibodies ( ANCA ) , which have not been previously described in association with LEP . There was no indication of systemic lupus erythematosus . While chloroquine produced no benefits , the skin lesions promptly cleared with dapsone . Step by step we reduced dapsone to a final dose of 50-75 mg per week . The ANCA titer decreased in parallel to the clinical improvement ."
],
"offsets": [
[
0,
581
]
]
}
] |
[
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t1",
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"male"
],
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[
14,
18
]
],
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{
"db_name": "UMLS",
"db_id": "C0024554"
},
{
"db_name": "UMLS",
"db_id": "C0086582"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
19,
26
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"lupuserythematosus"
],
"offsets": [
[
32,
50
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024138"
},
{
"db_name": "UMLS",
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},
{
"db_name": "UMLS",
"db_id": "C0024141"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"lupuserythematosus"
],
"offsets": [
[
32,
50
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041834"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"lupus"
],
"offsets": [
[
63,
68
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024138"
},
{
"db_name": "UMLS",
"db_id": "C0024131"
},
{
"db_name": "UMLS",
"db_id": "C0024141"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"panniculitis"
],
"offsets": [
[
69,
81
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030326"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"right"
],
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[
99,
104
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035621"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"lupus panniculitis"
],
"offsets": [
[
63,
81
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030327"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"anti-neutrophil-cytoplasmic"
],
"offsets": [
[
179,
206
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003209"
},
{
"db_name": "UMLS",
"db_id": "C0003204"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"anti-neutrophil-cytoplasmic"
],
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[
179,
206
]
],
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{
"db_name": "UMLS",
"db_id": "C0027950"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"antibodies"
],
"offsets": [
[
207,
217
]
],
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{
"db_name": "UMLS",
"db_id": "C0003241"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"ANCA"
],
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[
220,
224
]
],
"normalized": [
{
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"db_id": "C0103647"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"association"
],
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[
273,
284
]
],
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{
"db_name": "UMLS",
"db_id": "C0004083"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"lupus"
],
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[
332,
337
]
],
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{
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{
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},
{
"db_name": "UMLS",
"db_id": "C0024141"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"erythematosus"
],
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[
338,
351
]
],
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}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s4-t1",
"type": "umlsterm",
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"chloroquine"
],
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]
],
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{
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"db_id": "C0008269"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
399,
403
]
],
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{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"dapsone"
],
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[
434,
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]
],
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"db_id": "C0010980"
}
]
},
{
"id": "DerHautarzt.80490403.eng.abstr-s5-t1",
"type": "umlsterm",
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"dapsone"
],
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468,
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]
],
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{
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"db_id": "C0010980"
}
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},
{
"id": "DerHautarzt.80490403.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"ANCA"
],
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[
519,
523
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0103647"
}
]
}
] |
[] |
[] |
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DerHautarzt.80490408.eng.abstr
|
DerHautarzt.80490408.eng.abstr
|
[
{
"id": "DerHautarzt.80490408.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 7 year old boy presented with linear and whorled nevoid hypermelanosis ( LWNH ) . This entity , delineated in 1988 , is characterized by streaked or whorled , frequently reticulate hyperpigmented lesions following the lines of Blaschko without preceding inflammation and without atrophy . The age of onset is usually within the first 2 years of life . Histologically , there is a mild basal cell hyperpigmentation with prominent melanocytes . In contrast to earlier reports , we observed some melanophages in the upper dermis . Associated abnormalities have been reported in a few patients , but were absent in our case ."
],
"offsets": [
[
0,
623
]
]
}
] |
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"id": "DerHautarzt.80490408.eng.abstr-s4-t2",
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DerHautarzt.80490453.eng.abstr
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DerHautarzt.80490453.eng.abstr
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DerHautarzt.80490462.eng.abstr
|
DerHautarzt.80490462.eng.abstr
|
[
{
"id": "DerHautarzt.80490462.eng.abstr-passage-0",
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"Numerous different diseases lead to scarring alopecia with irreversible follicular destruction as a common ending . Current classifications are based on clinical , histopathological or prognostic parameters , as well as on pathogenetic criteria which allow only a rough assessment because the precise mechanisms leading to scarring alopecia are still unknown . Inadequacies of the established classifications are obvious when regarding special forms of scarring alopecia like lichen planopilaris or pseudopelade Brocq . In order to develop more satisfying classifications , recent insights into biology and pathology of the hair follicle and follicular cycling have to be considered . The most important structures for the survival of the hair follicle are the epithelial stem cells which reside in the follicular bulge and the fibroblasts of the dermal papilla including the molecular communication between these two cell populations . Research in the field of scarring alopecia should aim at defining the pathological processes on any of the above mentioned levels which will lead to an irreversible damage of the hair follicle thus allowing the development of new therapeutic agents ."
],
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[] |
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"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r26-t4.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t4",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r27-t6.1-t2.1",
"type": "treats",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t6",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r28-t2.1-t5.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t5",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r29-t7.1-t3.1",
"type": "produces",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t7",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r30-t1.1-t7.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t7",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r31-t6.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t6",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r32-t4.1-t9.1",
"type": "isa",
"arg1_id": "DerHautarzt.80490462.eng.abstr-s6-t4",
"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t9",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r33-t5.1-t7.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t7",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r34-t7.1-t6.1",
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"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t6",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r35-t7.1-t2.1",
"type": "co-occurs_with",
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"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490462.eng.abstr-s6-r36-t1.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.80490462.eng.abstr-s6-t2",
"normalized": []
}
] |
DerHautarzt.80490473.eng.abstr
|
DerHautarzt.80490473.eng.abstr
|
[
{
"id": "DerHautarzt.80490473.eng.abstr-passage-0",
"type": "abstract",
"text": [
"500 melanocytic lesions were examined by dermatoscopy using the ABCD rule prior to excision and histologic diagnosis . Regular nevi ( n=272) exhibited a score of 3.55+/-0.87, nevi with histologic signs of dysplasia ( n=190) a score of 4.0+/-0.68 and melanomas ( n=30) a score of 5.08+/-1.24. This study suggests that the ABCD rule of dermatoscopy greatly facilitates the evaluation of melanocytic lesions . When the dermatoscopic score is higher than 4.2 , melanoma should be considered ."
],
"offsets": [
[
0,
488
]
]
}
] |
[
{
"id": "DerHautarzt.80490473.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"ABCD"
],
"offsets": [
[
64,
68
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0338196"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"histologic"
],
"offsets": [
[
96,
106
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
107,
116
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"nevi"
],
"offsets": [
[
127,
131
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"nevi"
],
"offsets": [
[
175,
179
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"histologic"
],
"offsets": [
[
185,
195
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"signs"
],
"offsets": [
[
196,
201
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"melanomas"
],
"offsets": [
[
250,
259
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"ABCD"
],
"offsets": [
[
321,
325
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0338196"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"evaluation"
],
"offsets": [
[
371,
381
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220825"
}
]
},
{
"id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"melanoma"
],
"offsets": [
[
457,
465
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r1-t2.1-t7.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r2-t6.1-t2.1",
"type": "affects",
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"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r3-t4.1-t2.1",
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"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r4-t7.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r5-t6.1-t3.1",
"type": "diagnoses",
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"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r6-t4.1-t1.1",
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},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r7-t7.1-t1.1",
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"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r8-t6.1-t3.1",
"type": "treats",
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"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r9-t2.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r10-t2.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r11-t6.1-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r12-t6.1-t2.1",
"type": "diagnoses",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r13-t7.1-t6.1",
"type": "measures",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r14-t3.1-t7.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r15-t3.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r16-t6.1-t1.1",
"type": "diagnoses",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r17-t1.1-t7.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r18-t3.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r19-t6.1-t3.1",
"type": "affects",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r20-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r21-t6.1-t4.1",
"type": "treats",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t6",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r22-t1.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r23-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r24-t4.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490473.eng.abstr-s2-r25-t7.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490473.eng.abstr-s2-t7",
"arg2_id": "DerHautarzt.80490473.eng.abstr-s2-t3",
"normalized": []
}
] |
DerHautarzt.80490477.eng.abstr
|
DerHautarzt.80490477.eng.abstr
|
[
{
"id": "DerHautarzt.80490477.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Six patients with granuloma faciale , including patients with multiple lesions , were treated successfully with cryosurgery . Granuloma faciale is known to be difficult to treat . Cryosurgery is an effective and minimally invasive therapy for this granulomatous inflammation of the skin . It should be considered as an alternative to dapsone ."
],
"offsets": [
[
0,
343
]
]
}
] |
[
{
"id": "DerHautarzt.80490477.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patients"
],
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[
4,
12
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"granuloma"
],
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18,
27
]
],
"normalized": [
{
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"db_id": "C0018188"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
48,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cryosurgery"
],
"offsets": [
[
112,
123
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010408"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Granuloma"
],
"offsets": [
[
126,
135
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018188"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Cryosurgery"
],
"offsets": [
[
180,
191
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010408"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"therapy"
],
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[
231,
238
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"inflammation"
],
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[
262,
274
]
],
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{
"db_name": "UMLS",
"db_id": "C0021368"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
282,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.80490477.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"dapsone"
],
"offsets": [
[
334,
341
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010980"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.80490477.eng.abstr-s1-r1-t4.1-t3.1",
"type": "affects",
"arg1_id": "DerHautarzt.80490477.eng.abstr-s3-t4",
"arg2_id": "DerHautarzt.80490477.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-r2-t4.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.80490477.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-r3-t3.1-t4.1",
"type": "performs",
"arg1_id": "DerHautarzt.80490477.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.80490477.eng.abstr-s3-t4",
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},
{
"id": "DerHautarzt.80490477.eng.abstr-s1-r4-t1.1-t4.1",
"type": "performs",
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"arg2_id": "DerHautarzt.80490477.eng.abstr-s3-t4",
"normalized": []
},
{
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] |
DerHautarzt.80490482.eng.abstr
|
DerHautarzt.80490482.eng.abstr
|
[
{
"id": "DerHautarzt.80490482.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The combination of saltwater baths and subsequent ultraviolet irradiation is an effective treatment for psoriasis and atopic dermatitis . The aim of the present study was to determine the photosensitizing properties of two commercially available bath salts , original salt from the Dead Sea and sodium chloride . To address this issue , test areas on the volar aspects of the forearms were soaked with salt solutions for 15 minutes prior to ultraviolet-B ( UVB ) irradiation . The salt concentrations tested were 1% , 3% 5% and 15% . Tap water followed by UVB and UVB alone served as controls . Erythema was determined by visual and photometric measurement , and delayed tanning was assessed by colorimetry . Erythema obtained by wetting the skin prior to UVB irradiation was more pronounced than erythema induced by UVB alone . The most prominent erythema was yielded by tap water+UVB . The salts had a differing photosensitizing capacity and the strongest erythema was produced by the 5% solutions . There was only a moderate influence on delayed tanning by bathing the skin prior to irradiation . The results from the present study indicate that soaking the skin with salt solutions or tap water increases skin sensitivity to subsequent UVB irradiation . This may contribute to the effectiveness of salt water baths followed by UV irradiation and may account for an increased sunburn risk after bathing ."
],
"offsets": [
[
0,
1407
]
]
}
] |
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"id": "DerHautarzt.80490482.eng.abstr-s1-t2",
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"id": "DerHautarzt.80490482.eng.abstr-s1-t3",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t2",
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"bath"
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"id": "DerHautarzt.80490482.eng.abstr-s2-t3",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t4",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t5",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t6",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t7",
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"id": "DerHautarzt.80490482.eng.abstr-s2-t8",
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"id": "DerHautarzt.80490482.eng.abstr-s3-t2",
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"id": "DerHautarzt.80490482.eng.abstr-s3-t3",
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"id": "DerHautarzt.80490482.eng.abstr-s3-t5",
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"id": "DerHautarzt.80490482.eng.abstr-s4-t2",
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"id": "DerHautarzt.80490482.eng.abstr-s5-t1",
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] |
DerHautarzt.80490487.eng.abstr
|
DerHautarzt.80490487.eng.abstr
|
[
{
"id": "DerHautarzt.80490487.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Lupus erythematosus ( LE ) is a disease with a wide spectrum of cutaneous and systemic manifestations . Discoid LE ( DLE ) is the most common form of cutaneous LE ; the disseminated form of DLE is rare . We report an encouraging response to treatment with extracorporeal photopheresis ( ECP ) in a single patient with disseminated DLE who did not respond to conventional therapy . To the best of our knowledge this is the first successful use of ECP in the management of such a patient . Extracorporeal photopheresis is a therapeutic modality that has been under investigation for more than 12 years . Although originally developed for the treatment of cutaneous T-cell lymphoma , ECP has recently been used for the management of autoimmune diseases including systemic scleroderma , pemphigus vulgaris and SLE , as well as prevent organ rejection in patients with cardiac or kidney transplants and graft versus host disease after bone marrow transplantation ."
],
"offsets": [
[
0,
959
]
]
}
] |
[
{
"id": "DerHautarzt.80490487.eng.abstr-s1-t1",
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"Lupus"
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0,
5
]
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},
{
"db_name": "UMLS",
"db_id": "C0024141"
}
]
},
{
"id": "DerHautarzt.80490487.eng.abstr-s1-t2",
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"erythematosus"
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6,
19
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{
"id": "DerHautarzt.80490487.eng.abstr-s1-t3",
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"disease"
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},
{
"id": "DerHautarzt.80490487.eng.abstr-s2-t1",
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"DLE"
],
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117,
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"id": "DerHautarzt.80490487.eng.abstr-s2-t3",
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"form"
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},
{
"id": "DerHautarzt.80490487.eng.abstr-s2-t4",
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"DLE"
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193
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"id": "DerHautarzt.80490487.eng.abstr-s3-t1",
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"treatment"
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}
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},
{
"id": "DerHautarzt.80490487.eng.abstr-s3-t2",
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"single"
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},
{
"id": "DerHautarzt.80490487.eng.abstr-s3-t4",
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"DLE"
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},
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"id": "DerHautarzt.80490487.eng.abstr-s3-t5",
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{
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"id": "DerHautarzt.80490487.eng.abstr-s4-t1",
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"id": "DerHautarzt.80490487.eng.abstr-s4-t2",
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"id": "DerHautarzt.80490487.eng.abstr-s4-t3",
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"id": "DerHautarzt.80490487.eng.abstr-s5-t2",
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"id": "DerHautarzt.80490487.eng.abstr-s6-t2",
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{
"id": "DerHautarzt.80490487.eng.abstr-s6-t3",
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"lymphoma"
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"id": "DerHautarzt.80490487.eng.abstr-s6-t4",
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"id": "DerHautarzt.80490487.eng.abstr-s6-t5",
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{
"id": "DerHautarzt.80490487.eng.abstr-s6-t6",
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{
"id": "DerHautarzt.80490487.eng.abstr-s6-t8",
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{
"id": "DerHautarzt.80490487.eng.abstr-s6-t10",
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"kidney"
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"id": "DerHautarzt.80490487.eng.abstr-s6-t11",
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"transplants"
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}
]
},
{
"id": "DerHautarzt.80490487.eng.abstr-s6-t12",
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"id": "DerHautarzt.80490487.eng.abstr-s6-t14",
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{
"id": "DerHautarzt.80490487.eng.abstr-s6-t17",
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"id": "DerHautarzt.80490487.eng.abstr-s6-t20",
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]
}
] |
[] |
[] |
[
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DerHautarzt.80490492.eng.abstr
|
DerHautarzt.80490492.eng.abstr
|
[
{
"id": "DerHautarzt.80490492.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Despite its widespread use , the antimycotic nystatin rarely causes allergic reactions . We observed a case of acute generalized pustular exanthem with arthralgia and fever , after the oral administration of nystatin . A causal relationship was demonstrated by positive intracutaneous testing of the drug . Immunohistology revealed positive staining for C3 in the test area , whereas circulating immune complexes could not be identified . These findings are compatible with a type-II allergic reaction . Systemic prednisolone treatment led to a complete remission of the clinical symptoms within 11 days . In two test subjects who had never received nystatin intracutaneous testing was initially negative . After 3 weeks , both developed itching erythematous papules at the injection sites . Therefore , intracutaneous testing of nystatin involves the risk of sensitization ."
],
"offsets": [
[
0,
875
]
]
}
] |
[
{
"id": "DerHautarzt.80490492.eng.abstr-s1-t1",
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"use"
],
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23,
26
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490492.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nystatin"
],
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[
45,
53
]
],
"normalized": [
{
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"db_id": "C0028741"
}
]
},
{
"id": "DerHautarzt.80490492.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"allergic reactions"
],
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[
68,
86
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085600"
}
]
},
{
"id": "DerHautarzt.80490492.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"exanthem"
],
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138,
146
]
],
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{
"id": "DerHautarzt.80490492.eng.abstr-s2-t2",
"type": "umlsterm",
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[] |
[] |
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DerHautarzt.80490499.eng.abstr
|
DerHautarzt.80490499.eng.abstr
|
[
{
"id": "DerHautarzt.80490499.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Comèl-Netherton syndrome is a rare autosomal recessive hereditary disease . A 23-year old female presented with the classical triad of ichthyosis linearis circumflexa , trichorrhexis invaginata with bamboo hairs of up to 12 cm length and atopic diathesis . Nevertheless , more than 20 years passed before the final diagnosis was established . In addition , the patient was slightly mentally retarded and suffered from a genital papillomatosis , minimal hypergammaglobulinaemia and a marked bilateral eyelid ectropion , more severe than previously reported . Oral therapy with Acitretin was quite successful ."
],
"offsets": [
[
0,
612
]
]
}
] |
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"old"
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] |
[] |
[] |
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] |
DerHautarzt.80490505.eng.abstr
|
DerHautarzt.80490505.eng.abstr
|
[
{
"id": "DerHautarzt.80490505.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Christ-Siemens-Touraine syndrome ( CST syndrome ) is the rare an- or hypohidrotic form of the ectodermal dysplasia . During embryonic development , the formation and maturation of the central nervous system and the epithelia of the sense organs , skin , teeth , hair ( and less frequently the nails ) are disturbed . In addition to the cosmetic impairment , insufficient or absent secretion of sweat and sebum is particularly discomforting as it leads to extreme heat intolerance . The decreased number of apocrine sweat glands and mucous glands in the upper nasopharynx results in diminished resistance to respiratory infections . We describe typical features of the disease in a 60 year old female patient , distinguishing this disease from other forms of ectodermal dysplasia . Diagnostic criteria as well as therapeutic options are discussed ."
],
"offsets": [
[
0,
851
]
]
}
] |
[
{
"id": "DerHautarzt.80490505.eng.abstr-s1-t1",
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{
"id": "DerHautarzt.80490505.eng.abstr-s1-t2",
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"syndrome"
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s1-t3",
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"Christ-Siemens-Touraine syndrome"
],
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[
4,
36
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],
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"db_id": "C0162359"
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s1-t4",
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"CST syndrome"
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"ectodermal dysplasia"
],
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]
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"development"
],
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[
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]
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}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"nervous"
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t3",
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"text": [
"epithelia"
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"skin"
],
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251,
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]
],
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}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t5",
"type": "umlsterm",
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"teeth"
],
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]
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t6",
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"hair"
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"nails"
],
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297,
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]
],
"normalized": [
{
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"db_id": "C0027342"
}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"embryonic development"
],
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128,
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]
],
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"db_id": "C0243100"
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]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"nervous system"
],
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196,
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]
],
"normalized": [
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"db_id": "C0027763"
}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"sense organs"
],
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[
236,
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]
],
"normalized": [
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"db_id": "C0036665"
}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"central nervous system"
],
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188,
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],
"normalized": [
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"db_id": "C0007679"
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
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],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"secretion"
],
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385,
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]
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"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"sweat"
],
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]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s3-t4",
"type": "umlsterm",
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"sebum"
],
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],
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}
]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"heat"
],
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},
{
"id": "DerHautarzt.80490505.eng.abstr-s4-t1",
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"sweat"
],
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]
},
{
"id": "DerHautarzt.80490505.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"mucous"
],
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DerHautarzt.80490536.eng.abstr
|
DerHautarzt.80490536.eng.abstr
|
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],
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0,
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]
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] |
DerHautarzt.80490545.eng.abstr
|
DerHautarzt.80490545.eng.abstr
|
[
{
"id": "DerHautarzt.80490545.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Prognosis of systemic sclerosis ( scleroderma , Ssc ) is largely depending on involvement of internal organs . Abnormalities of the gastrointestinal tract are found most frequently ( 85% ) , especially decreased motility of the oesophagus , which has little impact on the longterm clinical course of Ssc . Pulmonary manifestations can be demonstrated in 40- 90% of patients ; one must distinguish between pulmonary hypertension or fibrotic lung disease . The heart is affected in 50% of cases . Patchy or diffuse myocardial fibrosis , as well as pericarditis and pericardial effusions can induce symptoms of arrhythmia or congestive heart failure . Renal involvement is associated with increased mortality and occurs in 45% of Ssc , producing proteinuria , hypertension , scleroderma renal crisis and renal failure . In conclusion , involvement of the lungs , heart and kidneys are determining factors for the longterm course of systemic sclerosis ."
],
"offsets": [
[
0,
949
]
]
}
] |
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DerHautarzt.80490552.eng.abstr
|
DerHautarzt.80490552.eng.abstr
|
[
{
"id": "DerHautarzt.80490552.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the years 1985 up to 1995 53 patients between 18 and 80 years of age ( mean age 54,7 years ) with histologically and clinically proven Zoon's balanitis were treated by circumcision . The majority of patients had symptoms for more than 12 months . In five cases they had lasted for 8 , 10 , 16 , 17 and 47 ( ! ) years . 30 patients were investigated by means of physical examination and questionaire in this retrospective study . Lesions involved glans in all patients , while in 17 of 30 patients both glans and prepuce were involved . None of the patients showed lesions of the prepuce only . In most cases Zoon's balanitis was successfully treated by circumcision in a period of two to four weeks . In four cases , psoriatic lesions , and in one case lichen ruber was diagnosed . In the remaining patient , whose circumcision was inadequate , a small area of balanitis persisted in the sulcus coronarius still covered by the foreskin . The curative effect of adequate circumcision in 100% of patients suggests that Zoon's balanitis is a relatively non-specific reactive balanitis caused by a disturbed \" preputial-ecology \" . It is remarkable that other distinct inflammatory diseases of glans and prepuce can show features which are identical to those Zoon's balanitis ."
],
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[
0,
1280
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.80490556.eng.abstr
|
DerHautarzt.80490556.eng.abstr
|
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"The closure of large circular defects on the scalp is technically difficult and cosmetically often not satisfying , if a free transplant is necessary . Following the technique of Tillmann described first in 1908 , several flaps shaped like a windmill can be combined . We report on 14 patients ( ages 41-88 years ) where large defects resulting from the excision of various tumors ( 5 melanomas , 5 basal cell carcinomas , 1 keratoacanthoma , 1 trichilemmal cyst , 1 squamous cell carcinoma , 1 skin metastasis ) were successfully closed by this method . The diameter of the defect ranged between 4 and 8 cm ( mean 5,7 cm ) . Size and number of the rotating flaps ( 3 or 4 ) was varied according to the size of the defect and the mobility of the surrounding tissue . The procedure was performed with local anesthesia in all cases . Wound healing occurred without complications except in 3 cases . 2 patients ( 63 years , 70 years ) developed small necrotic areas on the tips of the flaps . In a 74 year old man with a very large defect of 8 cm diameter , one flap of four underwent total necrosis . The cosmetic result was rated \" very good \" in 71,4% and \" good \" in 14,3% . The preservation of the terminal hair turned out to be of special advantage . The \" windmill procedure \" is an important addition to the surgical approaches for closure of large defects on the scalp , particularly in young patients ."
],
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1409
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]
}
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] |
DerHautarzt.80490560.eng.abstr
|
DerHautarzt.80490560.eng.abstr
|
[
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"id": "DerHautarzt.80490560.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia ."
],
"offsets": [
[
0,
765
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.80490566.eng.abstr
|
DerHautarzt.80490566.eng.abstr
|
[
{
"id": "DerHautarzt.80490566.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 23-year-old patient suffered from episodic angioedema of the face and neck , accompanied by diarrhea and abdominal pain . Additionally , the patient had bronchial asthma , recurrent nasal polyps and allergic rhinoconjunctivitis . Blood examination revealed leucocytosis with eosinophilia . Histological studies showed eosinophilic infiltrates in the skin and the gastrointestinal mucosa . Allergic food reactions and parasites were ruled out . With systemic corticosteroid treatment , the clinical symptoms and the eosinophilia disappeared . This case shows some parallels to previously described syndromes ( eosinophilic gastroenteritis , Samter's syndrome , episodic angioedema with eosinophilia ) , but to the best of our knowledge this combination of symptoms has not yet been reported ."
],
"offsets": [
[
0,
793
]
]
}
] |
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],
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]
],
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{
"id": "DerHautarzt.80490566.eng.abstr-s2-t3",
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],
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DerHautarzt.80490571.eng.abstr
|
DerHautarzt.80490571.eng.abstr
|
[
{
"id": "DerHautarzt.80490571.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A patient with porphyria cutanea tarda developed distinctive sclerodermoid changes with extensive dystrophic calcification and ulcerations in the sclerotic areas . In addition to these skin complications , over the course of 20 years other internal problems also appeared , such as diabetes mellitus , fatty cirrhosis and ocular inflammation . These severe clinical complications were related to omission of treatment and the alcohol abuse ."
],
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[
0,
441
]
]
}
] |
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}
] |
[] |
[] |
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] |
DerHautarzt.80490581.eng.abstr
|
DerHautarzt.80490581.eng.abstr
|
[
{
"id": "DerHautarzt.80490581.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 34-year-old HIV-infected African woman developed fever , weight loss and widespread papules on her trunk , arms and face . Skin biopsy and culture revealed histoplasmosis caused by Histoplasma capsulatum varietas capsulatum ( American histoplasmosis ) . Even though antimycotic treatment and intensive care were started immediately the patient died because of the systemic mycosis within a few days . Histoplasmosis is a rare disease in Europe but endemic in some areas of the USA ( e.g. Ohio , Mississippi ) and of Africa . Additionally histoplasma capsulatum varietas duboisii is endemic in Central and South Africa ."
],
"offsets": [
[
0,
621
]
]
}
] |
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{
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"id": "DerHautarzt.80490581.eng.abstr-s1-t5",
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"face"
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"id": "DerHautarzt.80490581.eng.abstr-s2-t2",
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"id": "DerHautarzt.80490581.eng.abstr-s2-t3",
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}
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},
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"id": "DerHautarzt.80490581.eng.abstr-s2-t4",
"type": "umlsterm",
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"histoplasmosis"
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"id": "DerHautarzt.80490581.eng.abstr-s2-t5",
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"id": "DerHautarzt.80490581.eng.abstr-s2-t6",
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"id": "DerHautarzt.80490581.eng.abstr-s3-t1",
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"id": "DerHautarzt.80490581.eng.abstr-s3-t4",
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"id": "DerHautarzt.80490581.eng.abstr-s3-t6",
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"id": "DerHautarzt.80490581.eng.abstr-s4-t4",
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}
] |
[] |
[] |
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] |
DerHautarzt.80490591.eng.abstr
|
DerHautarzt.80490591.eng.abstr
|
[
{
"id": "DerHautarzt.80490591.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Necrolytic migratory erythema ( NME ) is mostly associated with a pancreatic-A-cell-glucagonoma and is considered to be a well-defined cutaneous paraneoplastic syndrome . We report on a 74-year old female who atypically developed a NME after surgical treatment of a rectal adenocarcinoma . Continuous staging and laboratory investigation over four years gave no evidence of any metastasis or further neoplasia ."
],
"offsets": [
[
0,
411
]
]
}
] |
[
{
"id": "DerHautarzt.80490591.eng.abstr-s1-t1",
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"erythema"
],
"offsets": [
[
21,
29
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s1-t2",
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],
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[
160,
168
]
],
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"db_id": "C0039082"
}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"paraneoplastic syndrome"
],
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[
145,
168
]
],
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{
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"db_id": "C0030472"
}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s2-t1",
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"old"
],
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[
194,
197
]
],
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{
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}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s2-t2",
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"text": [
"female"
],
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[
198,
204
]
],
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{
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}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s2-t3",
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"surgical"
],
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[
242,
250
]
],
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{
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"db_id": "C0038895"
}
]
},
{
"id": "DerHautarzt.80490591.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"treatment"
],
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[
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],
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{
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},
{
"id": "DerHautarzt.80490591.eng.abstr-s2-t5",
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[] |
[] |
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DerHautarzt.80490626.eng.abstr
|
DerHautarzt.80490626.eng.abstr
|
[
{
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],
"offsets": [
[
0,
653
]
]
}
] |
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] |
[] |
[] |
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"id": "DerHautarzt.80490626.eng.abstr-s6-r7-t1.1-t3.1",
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}
] |
DerHautarzt.80490634.eng.abstr
|
DerHautarzt.80490634.eng.abstr
|
[
{
"id": "DerHautarzt.80490634.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the last decade an unusual amicrobial intertriginous pustulosis has been described in association with autoimmune disease in sixteen female patients . The clinical hallmark is a sterile pustular dermatosis preferentially located in intertriginous regions that responds to local or systemic corticosteroids . Histologic features are subcorneal sometimes spongiform neutrophilic pustules . We report an additional patient suffering from this unusual dermatosis . An overview of the patients described to date and a review of the literature are given in an attempt to delineate this amicrobial intertriginous pustulosis from the known pustular dermatoses ."
],
"offsets": [
[
0,
660
]
]
}
] |
[
{
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"association"
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93,
104
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}
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{
"id": "DerHautarzt.80490634.eng.abstr-s1-t2",
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"disease"
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121,
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{
"id": "DerHautarzt.80490634.eng.abstr-s1-t3",
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"text": [
"female"
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140,
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}
]
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-t4",
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"patients"
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147,
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"id": "DerHautarzt.80490634.eng.abstr-s1-t5",
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"autoimmune disease"
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110,
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{
"id": "DerHautarzt.80490634.eng.abstr-s2-t1",
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"sterile"
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185,
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}
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{
"id": "DerHautarzt.80490634.eng.abstr-s2-t2",
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"dermatosis"
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"id": "DerHautarzt.80490634.eng.abstr-s2-t3",
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"corticosteroids"
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{
"id": "DerHautarzt.80490634.eng.abstr-s3-t1",
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"Histologic"
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[
315,
325
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{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.80490634.eng.abstr-s4-t1",
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"patient"
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[
419,
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]
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{
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}
]
},
{
"id": "DerHautarzt.80490634.eng.abstr-s4-t2",
"type": "umlsterm",
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"dermatosis"
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{
"id": "DerHautarzt.80490634.eng.abstr-s5-t2",
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"date"
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"id": "DerHautarzt.80490634.eng.abstr-s5-t3",
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"review"
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"id": "DerHautarzt.80490634.eng.abstr-s5-t4",
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"literature"
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}
]
},
{
"id": "DerHautarzt.80490634.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"dermatoses"
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[
648,
658
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037274"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r1-t2.1-t3.2",
"type": "associated_with",
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{
"id": "DerHautarzt.80490634.eng.abstr-s1-r2-t5.1-t3.1",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r3-t5.1-t3.2",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r4-t1.1-t3.1",
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{
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r6-t5.1-t1.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r7-t5.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t5",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r8-t3.1-t1.1",
"type": "measurement_of",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r9-t1.1-t2.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r10-t3.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t5",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r11-t3.2-t1.1",
"type": "measurement_of",
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"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r12-t1.1-t5.1",
"type": "result_of",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t5",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r13-t3.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r14-t2.1-t3.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r15-t3.2-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s1-t3",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t5",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r16-t2.1-t1.1",
"type": "result_of",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r17-t1.1-t3.2",
"type": "affects",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s1-r18-t3.2-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s1-t3",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s2-r1-t3.1-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s2-r2-t1.1-t3.1",
"type": "produces",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s4-r1-t2.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s5-r1-t1.1-t3.1",
"type": "uses",
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"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490634.eng.abstr-s5-r2-t1.1-t2.1",
"type": "uses",
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"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t2",
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},
{
"id": "DerHautarzt.80490634.eng.abstr-s5-r3-t5.1-t1.1",
"type": "occurs_in",
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"arg2_id": "DerHautarzt.80490634.eng.abstr-s5-t1",
"normalized": []
}
] |
DerHautarzt.80490641.eng.abstr
|
DerHautarzt.80490641.eng.abstr
|
[
{
"id": "DerHautarzt.80490641.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The monoclonal dominant malignant T cells in mycosis fungoides ( MF ) carry identical TCR rearrangements . Their detection is a useful diagnostic tool . Thus , in routine diagnosis we investigated the occurrence of monoclonal T cells in skin biopsy samples of MF-patients by TCR-PCR , followed by temperature gradient gel electrophoresis ( TGGE ) . In 188 out of 208 MF patients , at least one skin sample with sufficient DNA quality for PCR analysis was obtained . Applying a consensus PCR for the TCR genes VI and J 1/2 , we detected monoclonal T cells in 122 cases ( 65% ) . In the remaining 66 cases , we performed two multiplex-PCRs , covering rearrangements of the other TCR genes . Here we found in 11 cases ( 6% ) predominant clonal rearrangements of VII-IV and J 1/2 and in 2 ( 1% ) those of VI-IV and J P1/2. In patients with MF , detecting rearrangements of only VI and J 1/2 is sufficient for PCR screening analysis . In 53 of the patients ( 28% ) the applied methods revealed no monoclonal T cells . This may be due to a low cell number , oligoclonal nature , chromosomal abberations or remaining of TCR in germline configuration ."
],
"offsets": [
[
0,
1144
]
]
}
] |
[
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"malignant"
],
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[
24,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cells"
],
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[
36,
41
]
],
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{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"mycosis"
],
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[
45,
52
]
],
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{
"db_name": "UMLS",
"db_id": "C0026946"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"TCR"
],
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[
86,
89
]
],
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{
"db_name": "UMLS",
"db_id": "C0034790"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"T cells"
],
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[
34,
41
]
],
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"mycosis fungoides"
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[
45,
62
]
],
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{
"db_name": "UMLS",
"db_id": "C0026948"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"diagnostic"
],
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[
135,
145
]
],
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{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
171,
180
]
],
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{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"occurrence"
],
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[
201,
211
]
],
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{
"db_name": "UMLS",
"db_id": "C0243132"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"cells"
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[
228,
233
]
],
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{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"skin"
],
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[
237,
241
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"biopsy"
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242,
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],
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{
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{
"db_name": "UMLS",
"db_id": "C0005558"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"temperature"
],
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[
297,
308
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],
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{
"db_name": "UMLS",
"db_id": "C0039476"
},
{
"db_name": "UMLS",
"db_id": "C0005903"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"gel"
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[
318,
321
]
],
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{
"db_name": "UMLS",
"db_id": "C0017243"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"electrophoresis"
],
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[
322,
337
]
],
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{
"db_name": "UMLS",
"db_id": "C0013855"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"T cells"
],
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[
226,
233
]
],
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"patients"
],
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[
370,
378
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
394,
398
]
],
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{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"DNA"
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[
422,
425
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012854"
}
]
},
{
"id": "DerHautarzt.80490641.eng.abstr-s4-t4",
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DerHautarzt.80490646.eng.abstr
|
DerHautarzt.80490646.eng.abstr
|
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{
"id": "DerHautarzt.80490646.eng.abstr-passage-0",
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"text": [
"By means of modern color-coded duplex sonography ( CCDS ) even very small vessels can be visualized . Maximum resolution nowadays is about 0.5 mm diameter of the vessel . We compared the use of CCDS and angiography in studying of acral perfusion . Besides morphologic criteria , hemodynamic criteria were recorded . Arteries in healthy fingers appear as long and straight vessels with a clearly defined border . The physiological maximal blood flow velocity exceded 20 cm/s . CCDS revealed tortuosity of finger arteries as typical finding in thrombangiitis obliterans . Segmental stenosis can either be identified morphologically or quantified by measurement of the flow velocity with poststenotic maximal systolic velocities of less than 20 cm/s or by the acceleration of the blood flow within the stenosis , as proven by angiographic examinations . CCDS is suitable for evaluation of acral perfusion in patients suffering from secondary Raynaud's syndrome . Apart from diagnosis of disturbed acral circulation , other possible applications of CCDS are in in the surgical field , for example replantations in hand or finger surgery ."
],
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] |
DerHautarzt.80490651.eng.abstr
|
DerHautarzt.80490651.eng.abstr
|
[
{
"id": "DerHautarzt.80490651.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cosmetics and ophthalmological topical preparations are the main causes of allergic contact eczema about the eye . In most cases , clinical signs are conjunctival injection , blepharitis , periorbital dermatitis and edema of lids , often combined with itching . Pure edematous swelling of the eyelids should not immediately be blamed on a contact allergy , but sufficiently evaluated to exclude a benign or malignant process of the eyelids , orbita , lacrimal duct and paranasal sinus . We present a patient with pure edematous swelling of the eyelids due to a contact allergy by the sympathicomimetic phenylephrine hydrochloride , an uncommon allergen ."
],
"offsets": [
[
0,
654
]
]
}
] |
[
{
"id": "DerHautarzt.80490651.eng.abstr-s1-t1",
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"Cosmetics"
],
"offsets": [
[
0,
9
]
],
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{
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"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"causes"
],
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[
65,
71
]
],
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{
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"db_id": "C0015127"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"eczema"
],
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[
92,
98
]
],
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{
"db_name": "UMLS",
"db_id": "C0013595"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"eye"
],
"offsets": [
[
109,
112
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015392"
},
{
"db_name": "UMLS",
"db_id": "C0496836"
},
{
"db_name": "UMLS",
"db_id": "C0023924"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"contact eczema"
],
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[
84,
98
]
],
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{
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"db_id": "C0011616"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"signs"
],
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[
140,
145
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"injection"
],
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[
163,
172
]
],
"normalized": [
{
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"db_id": "C0021485"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"blepharitis"
],
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[
175,
186
]
],
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{
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"db_id": "C0005741"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"dermatitis"
],
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[
201,
211
]
],
"normalized": [
{
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"db_id": "C0011603"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"edema"
],
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[
216,
221
]
],
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"db_id": "C0013604"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"itching"
],
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[
252,
259
]
],
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"db_id": "C0033774"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"eyelids"
],
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[
293,
300
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"allergy"
],
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347,
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]
],
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}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"malignant"
],
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[
407,
416
]
],
"normalized": [
{
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"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"eyelids"
],
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432,
439
]
],
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}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"sinus"
],
"offsets": [
[
479,
484
]
],
"normalized": [
{
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"db_id": "C0030471"
}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"paranasal sinus"
],
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[
469,
484
]
],
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},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"patient"
],
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500,
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]
],
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"db_id": "C0030705"
}
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},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t2",
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"text": [
"eyelids"
],
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]
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]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t3",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"phenylephrine"
],
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602,
615
]
],
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"db_id": "C0031469"
}
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},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
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],
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]
],
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}
]
},
{
"id": "DerHautarzt.80490651.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"phenylephrine hydrochloride"
],
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[
602,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031470"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.80490654.eng.abstr
|
DerHautarzt.80490654.eng.abstr
|
[
{
"id": "DerHautarzt.80490654.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since birth , a 43 year-old man displayed a nevus sebaceus on the right temple . The histopathology revealed two distinct adnexal neoplasms associated with this lesion : a syringocystadenoma papilliferum and a trichoblastoma . We describe the combination of these entities in this report ."
],
"offsets": [
[
0,
289
]
]
}
] |
[
{
"id": "DerHautarzt.80490654.eng.abstr-s1-t1",
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"birth"
],
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6,
11
]
],
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"db_id": "C0005615"
}
]
},
{
"id": "DerHautarzt.80490654.eng.abstr-s1-t2",
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"man"
],
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[
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31
]
],
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}
]
},
{
"id": "DerHautarzt.80490654.eng.abstr-s1-t3",
"type": "umlsterm",
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"nevus"
],
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[
44,
49
]
],
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"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.80490654.eng.abstr-s1-t4",
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"right"
],
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[
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71
]
],
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}
]
},
{
"id": "DerHautarzt.80490654.eng.abstr-s2-t1",
"type": "umlsterm",
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"histopathology"
],
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[
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99
]
],
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"db_id": "C0243140"
}
]
},
{
"id": "DerHautarzt.80490654.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"neoplasms"
],
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[
130,
139
]
],
"normalized": [
{
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"db_id": "C0027651"
},
{
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"db_id": "C0036210"
}
]
}
] |
[] |
[] |
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"arg2_id": "DerHautarzt.80490654.eng.abstr-s2-t2",
"normalized": []
}
] |
DerHautarzt.80490657.eng.abstr
|
DerHautarzt.80490657.eng.abstr
|
[
{
"id": "DerHautarzt.80490657.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Glomus tumors ( glomangiomata ) are benign tumors arising from glomus cells . Multiple glomangiomata are less frequent and less painful than the solitary variant , which is usually located subungually . Nonetheless multiple glomangiomata - sometimes being sensitive to pressure and changes in temperature - may cause considerable discomfort . Treatment of multiple glomangiomata is problematic because of the often large number of tumors . Sclerotherapy represents an alternative to surgical and cryosurgical therapy . We report on sclerotherapy in a 35 year old female patient with multiple hereditary glomus tumors ."
],
"offsets": [
[
0,
618
]
]
}
] |
[
{
"id": "DerHautarzt.80490657.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"tumors"
],
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[
7,
13
]
],
"normalized": [
{
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"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.80490657.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"glomangiomata"
],
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[
16,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0334421"
}
]
},
{
"id": "DerHautarzt.80490657.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
43,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.80490657.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cells"
],
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[
70,
75
]
],
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{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.80490657.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Glomus tumors"
],
"offsets": [
[
0,
13
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017653"
}
]
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] |
[] |
[] |
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DerHautarzt.80490687.eng.abstr
|
DerHautarzt.80490687.eng.abstr
|
[
{
"id": "DerHautarzt.80490687.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recently a mutation of the human homologue of the murine hairless gene on chromosome 8p12 has been demonstrated in a Parkistani kindred with autosomal recessive atrichia universalis . Of the various forms of hereditary human hair loss , collectively and incorrectly termed alopecias , congenital universal alopecia , or rather atrichia , represents a rare disease which has nothing to do with the most frequent causes of hair loss , specifically androgenetic alopecia ( AGA ) and alopecia areata ( AA ) . It may preferably be referred to as generalized atrichia , since alopecia universalis is also the term used for the most extreme form of disease progression in AA leading to complete loss of scalp and body hair . Interestingly the hairless mouse has formerly been proposed to be the animal model for atrichia with papular lesions ( papular atrichia ) , which is likewise transmitted as an autosomal recessive trait . In contrast to these rare forms of hereditary atrichia with a Mendelian pattern of inheritance , both AGA and AA are considered to be polygenic , with hormonal and immunologic factors , respectively , modifying the phenotypic expression . Nevertheless , pinpointing a gene that encodes a transcription factor involved in hair growth may provide a more targeted approach to treat disorders of hair growth through transcriptional control of a variety of cytokines and growth factors implicated in the hair growth cycle ."
],
"offsets": [
[
0,
1440
]
]
}
] |
[
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"human"
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{
"id": "DerHautarzt.80490687.eng.abstr-s1-t3",
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"murine"
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"gene"
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{
"id": "DerHautarzt.80490687.eng.abstr-s1-t6",
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{
"id": "DerHautarzt.80490687.eng.abstr-s2-t2",
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},
{
"id": "DerHautarzt.80490687.eng.abstr-s2-t3",
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"hair"
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},
{
"id": "DerHautarzt.80490687.eng.abstr-s2-t4",
"type": "umlsterm",
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"alopecias"
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[] |
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DerHautarzt.80490690.eng.abstr
|
DerHautarzt.80490690.eng.abstr
|
[
{
"id": "DerHautarzt.80490690.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Indications for dermatological laser therapy have been enlarged during the last few years . In this article the physics and biophysics of laser therapy and the common laser systems in dermatology are described . Modern pulsed laser systems are combined with little side effects . Nevertheless , suc-cessfully used alternative methods should not be neglected ."
],
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[
0,
359
]
]
}
] |
[
{
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]
}
] |
[] |
[] |
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{
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},
{
"id": "DerHautarzt.80490690.eng.abstr-s3-r1-t1.1-t2.1",
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"arg2_id": "DerHautarzt.80490690.eng.abstr-s3-t2",
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}
] |
DerHautarzt.80490705.eng.abstr
|
DerHautarzt.80490705.eng.abstr
|
[
{
"id": "DerHautarzt.80490705.eng.abstr-passage-0",
"type": "abstract",
"text": [
"New antifungals for oral therapy have improved the chances of healing onychomycoses . Nevertheless , in daily practice the failure rate is 20-30% both with itraconazole and terbinafine . In our investigations for the fungicidal effects of terbinafine , we could show that the same strain of Trichophyton rubrum or T. mentagrophytes in the rest period needs 1000 times higher concentration of terbinafine ( 2,0 to 0,002 µg/ml) for complete fungal killing as in the growth phase . Thus resting fungi in the nail are not harmed , and if the concentration of terbinafine is lower than the MIC for the fungi , they can cause a relapse . Itraconazole is a fungistatic agent . Its concentration in the nail plate must be higher than the MIC for the causative fungi for a long time - 10 to 12 months . The usual short-term treatment of onychomycosis over 3 months can be insufficient in individual cases such as patients with disorders , e.g. circulatory disorders or slowed nail growth ."
],
"offsets": [
[
0,
980
]
]
}
] |
[
{
"id": "DerHautarzt.80490705.eng.abstr-s1-t1",
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"antifungals"
],
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4,
15
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],
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"db_id": "C0003308"
}
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},
{
"id": "DerHautarzt.80490705.eng.abstr-s1-t2",
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],
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25,
32
]
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}
]
},
{
"id": "DerHautarzt.80490705.eng.abstr-s2-t1",
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},
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] |
DerHautarzt.80490709.eng.abstr
|
DerHautarzt.80490709.eng.abstr
|
[
{
"id": "DerHautarzt.80490709.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background : Dermatologic surgery is usually possible under local anesthesia , even when large amounts of highly diluted anesthetic solutions are required ( tumescent anesthesia ) . Although special pumps now render such large injections effortless , it is usually still necessary to hold and guide the injection cannula . We have overcome this handicap by injecting anesthetic solutions slowly with an Infusomat , which allows slow painless automatic infusion into the subcutaneous layer ."
],
"offsets": [
[
0,
490
]
]
}
] |
[
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],
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]
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],
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}
] |
[] |
[] |
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},
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"id": "DerHautarzt.80490709.eng.abstr-s3-r1-t1.1-t2.1",
"type": "interacts_with",
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"id": "DerHautarzt.80490709.eng.abstr-s3-r2-t2.1-t1.1",
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}
] |
DerHautarzt.80490714.eng.abstr
|
DerHautarzt.80490714.eng.abstr
|
[
{
"id": "DerHautarzt.80490714.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Port wine stains ( PWS ) can lead to considerable emotional distress . The present study evaluated a ) the coping with illness , the quality of life and the body image of patients with PWS and b ) the effects of dye laser treatment on psychosocial parameters . Seventy PWS patients undergoing treatment with the flashlamp-pumped pulsed dye laser ( FPDL ) were assessed with questionnaires regarding coping with skin disease , quality of life and body image . Major clinical criterium was the lightening of PWS under treatment . PWS patients showed significant social phobia and avoidance similar to patient suffering from chronic skin diseases . The anxiety correlated with size and darkness of the PWS . In terms of helplessness and depressive mood , PWS patients were less affected than the comparison group . Also , PWS patients had reductions in quality of life and in body image . The coping strategies had a differential effect on the body image . Since there is a correlation between lightening of the PWS and reduction of emotional distress , FDPL therapy can be considered an effective treatment of PWS also in psychosocial terms ."
],
"offsets": [
[
0,
1140
]
]
}
] |
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{
"id": "DerHautarzt.80490714.eng.abstr-s1-t1",
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"wine"
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9
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}
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},
{
"id": "DerHautarzt.80490714.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"stains"
],
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10,
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]
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}
]
},
{
"id": "DerHautarzt.80490714.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"Port wine stains"
],
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0,
16
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"id": "DerHautarzt.80490714.eng.abstr-s2-t1",
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"life"
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},
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"id": "DerHautarzt.80490714.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"dye"
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212,
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"id": "DerHautarzt.80490714.eng.abstr-s2-t4",
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"id": "DerHautarzt.80490714.eng.abstr-s2-t5",
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}
]
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{
"id": "DerHautarzt.80490714.eng.abstr-s2-t6",
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"body image"
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},
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"id": "DerHautarzt.80490714.eng.abstr-s2-t7",
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"text": [
"quality of life"
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133,
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},
{
"id": "DerHautarzt.80490714.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.80490714.eng.abstr-s3-t4",
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"id": "DerHautarzt.80490714.eng.abstr-s3-t5",
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"id": "DerHautarzt.80490714.eng.abstr-s3-t6",
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"id": "DerHautarzt.80490714.eng.abstr-s3-t7",
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"id": "DerHautarzt.80490714.eng.abstr-s3-t8",
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"id": "DerHautarzt.80490714.eng.abstr-s3-t11",
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"id": "DerHautarzt.80490714.eng.abstr-s4-t1",
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"id": "DerHautarzt.80490714.eng.abstr-s5-t2",
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"id": "DerHautarzt.80490714.eng.abstr-s5-t6",
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"id": "DerHautarzt.80490714.eng.abstr-s6-t1",
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"id": "DerHautarzt.80490714.eng.abstr-s6-t2",
"type": "umlsterm",
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"darkness"
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"id": "DerHautarzt.80490714.eng.abstr-s7-t1",
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]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.80490714.eng.abstr-s1-r3-t1.1-t2.1",
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},
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},
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] |
DerHautarzt.80490719.eng.abstr
|
DerHautarzt.80490719.eng.abstr
|
[
{
"id": "DerHautarzt.80490719.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Small basal cell carcinomas of the trunk are usually regarded as relatively harmless . In contrast , large and ulcerating basal cell carcinomas may become a therapeutic challenge with a less favourable prognosis and high risk of recurrence . The development of mutilating giant basal cell carcinomas appears less due to the biological aggressive character of the tumors , but rather to the patients ' attitude of neglect . The case of a 62-year-old patient , featuring such attitude , demonstrates how a common basal cell carcinoma of the trunk can grow over a period of years to a troublesome ulcerating tumor ."
],
"offsets": [
[
0,
612
]
]
}
] |
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DerHautarzt.80490722.eng.abstr
|
DerHautarzt.80490722.eng.abstr
|
[
{
"id": "DerHautarzt.80490722.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 78 year old women developed acute fingertip necrosis just a few days after starting dihydroergotamine . The lesions healed in 3 weeks after the medication was stopped . The patient had suffered from Raynaud syndrome for 5 years and limited systemic sclerosis was diagnosed during the necrotic episode . Advanced age and microangiopathies are contraindications to the use of ergot-containing preparations ."
],
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[
0,
407
]
]
}
] |
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46,
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175,
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}
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},
{
"id": "DerHautarzt.80490722.eng.abstr-s4-t2",
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] |
[] |
[] |
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{
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DerHautarzt.80490725.eng.abstr
|
DerHautarzt.80490725.eng.abstr
|
[
{
"id": "DerHautarzt.80490725.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although the association between administration of the antitumor agent bleomycin and the development of cutanous fibrosis is established , there are only a small number of cases of bleomycin-induced scleroderma described in the literature . We report the development of generalised scleroderma with wide spread hyperpigmentation in a 52-year-old male patient , who received a total dose of 360 mg bleomycin in combination with cisplatin and etoposid for therapy of a malignant testicular seminoma . The clinical cutaneous alterations as well as the histological findings were indistinguishable from those encountered in progressive systemic sclerosis ( PSS ) . In contrast to PSS however , Raynaud's phenomenon , cutaneous calcinosis , teleangiectasia , arthritis and involvement of additional organs were all absent . PSS-typical auto-antibodies were negative . Even 18 months after discontinuation of the drug and treatment with UVA1 phototherapy ( 3-4 times per week with 20 J/cm2) as well as physiotherapy , the skin changes had still not resolved . Based on our case and a detailed review of the literature , we discuss characteristics of bleomycin-induced scleroderma including pathogenesis , treatment modalities and course ."
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] |
DerHautarzt.80490730.eng.abstr
|
DerHautarzt.80490730.eng.abstr
|
[
{
"id": "DerHautarzt.80490730.eng.abstr-passage-0",
"type": "abstract",
"text": [
"There is a wide morphological variety in the appearance of melanocytic nevi . We report a case of a 77-year-old woman with a pedun-culated , lobulated intradermal nevus on her trunk . For this grape-like clinical variant , we propose the term \" corymbiform nevus \" ."
],
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[
0,
266
]
]
}
] |
[
{
"id": "DerHautarzt.80490730.eng.abstr-s1-t1",
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}
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},
{
"id": "DerHautarzt.80490730.eng.abstr-s1-t2",
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71,
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{
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"woman"
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},
{
"id": "DerHautarzt.80490730.eng.abstr-s2-t2",
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}
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},
{
"id": "DerHautarzt.80490730.eng.abstr-s2-t3",
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]
},
{
"id": "DerHautarzt.80490730.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.80490730.eng.abstr-s3-t2",
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"nevus"
],
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257,
262
]
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] |
[] |
[] |
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DerHautarzt.80490770.eng.abstr
|
DerHautarzt.80490770.eng.abstr
|
[
{
"id": "DerHautarzt.80490770.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In spite of their tumor's origin in the uveal tract , many patients suffering from advanced uveal melanoma are admitted to dermatological oncology units . Most patients with metastases from uveal melanoma receive treatments that were established for stage IV cutaneous melanoma . However , both the biology as well as the metastastic behaviour of this tumor is different from cutaneous melanoma . Lymphatic metastases do not occur , and hematogeneous metastases usually occur later and predominantly involve the liver . The prognosis is very bad ranging from 2 to 5 months ."
],
"offsets": [
[
0,
574
]
]
}
] |
[
{
"id": "DerHautarzt.80490770.eng.abstr-s1-t1",
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{
"id": "DerHautarzt.80490770.eng.abstr-s1-t2",
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},
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"id": "DerHautarzt.80490770.eng.abstr-s1-t3",
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"id": "DerHautarzt.80490770.eng.abstr-s2-t3",
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196,
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"id": "DerHautarzt.80490770.eng.abstr-s2-t4",
"type": "umlsterm",
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"treatments"
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"db_id": "C0087111"
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},
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"id": "DerHautarzt.80490770.eng.abstr-s2-t5",
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"id": "DerHautarzt.80490770.eng.abstr-s2-t6",
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"id": "DerHautarzt.80490770.eng.abstr-s3-t3",
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"tumor"
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},
{
"id": "DerHautarzt.80490770.eng.abstr-s3-t4",
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]
},
{
"id": "DerHautarzt.80490770.eng.abstr-s4-t4",
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],
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397,
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]
}
] |
[] |
[] |
[
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DerHautarzt.80490774.eng.abstr
|
DerHautarzt.80490774.eng.abstr
|
[
{
"id": "DerHautarzt.80490774.eng.abstr-passage-0",
"type": "abstract",
"text": [
"High dose intravenous immunoglobulins ( IVIG ) have been shown to be effective in different autoimmune diseases . We report on the use of IVIG in patients with pemphigus vulgaris ( PV ) or pemphigus foliaceus ( PF ) resistent to conventional therapy . Six patients who presented with a relapse of their disease following conventional immunosuppressive treatment with prednisolone and azathioprine were additionally treated with 2 g/kg of IVIG every four weeks . Six to nine cycles of this therapy were given to each patient . All patients showed healing of their blisters without evidence of relapse even when steroids and immunosuppressants were tapered . None of the patients relapsed within one year of follow-up , although IVIG treatment was discontinued . Side effects of IVIG treatment were moderate with only slight evidence of headaches . We suggest that adjuvant treatment of PV and PF resistant to conventional immunosuppressive strategies is a useful addition to our therapeutic arsenal in both diseases ."
],
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[
0,
1016
]
]
}
] |
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DerHautarzt.80490777.eng.abstr
|
DerHautarzt.80490777.eng.abstr
|
[
{
"id": "DerHautarzt.80490777.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The decline of STD in the region of Rostock , Germany , since 1945 is explained by a decreasing incidence of gonorrhoea and trichomoniasis . On the other hand chlamydial and candidal infections have increased . The rate of chlamydia infections was about 45% in our venerological patients , as common as gonorrhea used to be . Genital candidal infections were to be found in 23% . Mycoplasmas were identified in 15% , usually combined with other pathogens except in some cases of vaginitis ."
],
"offsets": [
[
0,
490
]
]
}
] |
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18
]
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{
"id": "DerHautarzt.80490777.eng.abstr-s1-t2",
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],
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]
],
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},
{
"id": "DerHautarzt.80490777.eng.abstr-s1-t4",
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"text": [
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],
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],
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},
{
"id": "DerHautarzt.80490777.eng.abstr-s3-t1",
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{
"id": "DerHautarzt.80490777.eng.abstr-s3-t2",
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479,
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] |
[] |
[] |
[
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] |
DerHautarzt.80490781.eng.abstr
|
DerHautarzt.80490781.eng.abstr
|
[
{
"id": "DerHautarzt.80490781.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Seborrhoic dermatitis is an erythemato-squamous condition of unknown etiology with a prevalence of approximately 2.5% . Frequently difficult to treat , it may respond to the application of low doses of dithranol , a substance which can induce a pustular dermatitis as an adverse side effect depending on the applied concentration and individual susceptibility . We describe a pustular dermatitis after the application of a preparation containing dithranol at an erroneously high concentration in a 30-year-old patient with seborrhoic dermatitis ."
],
"offsets": [
[
0,
546
]
]
}
] |
[
{
"id": "DerHautarzt.80490781.eng.abstr-s1-t1",
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"dermatitis"
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11,
21
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},
{
"id": "DerHautarzt.80490781.eng.abstr-s1-t2",
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]
},
{
"id": "DerHautarzt.80490781.eng.abstr-s1-t3",
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"prevalence"
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85,
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}
]
},
{
"id": "DerHautarzt.80490781.eng.abstr-s2-t1",
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"dermatitis"
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254,
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"id": "DerHautarzt.80490781.eng.abstr-s2-t2",
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"side effect"
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"id": "DerHautarzt.80490781.eng.abstr-s3-t2",
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479,
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{
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}
] |
[] |
[] |
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{
"id": "DerHautarzt.80490781.eng.abstr-s2-r10-t4.1-t1.1",
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{
"id": "DerHautarzt.80490781.eng.abstr-s2-r11-t1.1-t4.1",
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{
"id": "DerHautarzt.80490781.eng.abstr-s2-r12-t1.1-t2.1",
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{
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{
"id": "DerHautarzt.80490781.eng.abstr-s3-r2-t4.1-t2.1",
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{
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{
"id": "DerHautarzt.80490781.eng.abstr-s3-r4-t2.1-t1.1",
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},
{
"id": "DerHautarzt.80490781.eng.abstr-s3-r5-t4.1-t2.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.80490781.eng.abstr-s3-t2",
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},
{
"id": "DerHautarzt.80490781.eng.abstr-s3-r6-t1.1-t2.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.80490781.eng.abstr-s3-t2",
"normalized": []
}
] |
DerHautarzt.80490784.eng.abstr
|
DerHautarzt.80490784.eng.abstr
|
[
{
"id": "DerHautarzt.80490784.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Papillary cystadenoma of the minor salivary glands is a rare benign tumor that clinically resembles a mucous cyst . We demonstrate its histologic features and differential diagnosis by a case report . Benign and malignant neoplasms of the minor salivary glands are not well acknowledged in the dermatologic literature , but should be considered in the differential diagnosis for mucous cysts ."
],
"offsets": [
[
0,
393
]
]
}
] |
[
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"cystadenoma"
],
"offsets": [
[
10,
21
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010633"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"minor"
],
"offsets": [
[
29,
34
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026193"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"tumor"
],
"offsets": [
[
68,
73
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"mucous"
],
"offsets": [
[
102,
108
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026727"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"cyst"
],
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[
109,
113
]
],
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{
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"db_id": "C0010709"
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]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"Papillary cystadenoma"
],
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[
0,
21
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010636"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"salivary glands"
],
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[
35,
50
]
],
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{
"db_name": "UMLS",
"db_id": "C0036098"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"benign tumor"
],
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61,
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],
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"db_id": "C0086692"
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},
{
"id": "DerHautarzt.80490784.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"minor salivary glands"
],
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[
29,
50
]
],
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{
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"db_id": "C0036099"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"histologic"
],
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[
135,
145
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
172,
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"db_id": "C0011900"
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]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s2-t3",
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"differential diagnosis"
],
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}
]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s2-t4",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.80490784.eng.abstr-s3-t1",
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"text": [
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212,
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]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"neoplasms"
],
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[
222,
231
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],
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"db_id": "C0027651"
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]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"minor"
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[
239,
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],
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{
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]
},
{
"id": "DerHautarzt.80490784.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"literature"
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] |
DerHautarzt.80490818.eng.abstr
|
DerHautarzt.80490818.eng.abstr
|
[
{
"id": "DerHautarzt.80490818.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cicatrical pemphigoid ( CP ) comprises a groupf of patients with a chronic subepidermal blistering disease which primarily involves mucous membranes ; lesions characteristically heal with scarring . Immunofluorescence investigations typically demonstrate deposits of tissue bound and circulating immunoreactants of the IgG and less frequently of the IgA class in a linear pattern along the basement membrane zone . These autoantibodies are thought to play an important role in the blister formation of CP . Most patients show binding to the bullous pemphigoid antigen 2 ( BPag2), collagen type XVII , with a molecularweight of 180 kD . A smaller group of patients with CP have autoantibodies to laminin 5. Animal models confirm that autoantibodies binding to these two adhesion molecules ( BPag2 and laminin 5 ) are important in blister formation . There are other autoantigens described in CP ; however , they are only found in small groups of CP patients and most of them are not further characterised . The described molecules are part of the hemidesmosomal adhesion complex . Impaired function of any component of this complex may lead to a separation of the epidermis from the dermis ; better knowledge about the single molecules and the exact localisation of epitopes within these molecules may lead to further understanding of the clinical picture ."
],
"offsets": [
[
0,
1356
]
]
}
] |
[
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11,
21
]
],
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"patients"
],
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51,
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]
],
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]
},
{
"id": "DerHautarzt.80490818.eng.abstr-s1-t3",
"type": "umlsterm",
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"blistering"
],
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[
88,
98
]
],
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"db_id": "C0005758"
}
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},
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"disease"
],
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]
],
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{
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"mucous"
],
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]
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},
{
"id": "DerHautarzt.80490818.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"membranes"
],
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]
],
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DerHautarzt.80490826.eng.abstr
|
DerHautarzt.80490826.eng.abstr
|
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[] |
[] |
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DerHautarzt.80490835.eng.abstr
|
DerHautarzt.80490835.eng.abstr
|
[
{
"id": "DerHautarzt.80490835.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The differential diagnosis of cicatricial alopecia includes a wide variety of diseases . A 60-years-old woman was admitted to the hospital because of an unsuccessfully treated , progressive pseudopelede of Brocq . Further examination revealed an borreliosis ( Stage III ) . After 3 weeks of treatment with intravenous Cefotaxime ( Claforan ) , follow-up examination one year later show an complete arrest of the alopecia . This first description of cicatricial alopecia to be causally related to borreliosis Stage III extends the differential diagnosis of pseudopelede of Brocq and offers a curative therapy ."
],
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[
0,
609
]
]
}
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[] |
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DerHautarzt.80490844.eng.abstr
|
DerHautarzt.80490844.eng.abstr
|
[
{
"id": "DerHautarzt.80490844.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a prospective trial patients were interviewed in two periods , from 1988 to 1990 and from 1993 to 1995. Ninety out of 189 patients ( 47,6% ) with a histologically confirmed diagnosis of malignant melanoma who noted morphological changes in a pigmented lesion reported the mole had been present at least 10 years . 20,7% stated it was present since birth . 156 out of 189 patients ( 82,5% ) noticed changes in the lesion over the time . Growth , discolouration and elevation were the most frequent changes but no significant early sign of disease was found . Bleeding and crusting were found with tumor thickness > 1,5 mm and thus be signs of an advanced stage . Almost 6 months passed until half of the patients visited a physician , either because of changes in the mole or in the lesion was detected during other medical examinations . In the second period of the survey from 1993 to 1995 the physician was frequently consulted earlier . The main reasons for the delay between identification by the patient and seeking medical cedure were lack of symptoms and the notion that the lesion was harmless . Only 72 out of 189 patients ( 38,1% ) visited the physician on their own initiative . The primary evaluation of the \" pigmental lesion \" was done by a primary care physician in 57% , by a dermatologist in 32% and by others in 11% of our cases . A diagnosis of a non-melanoma was made and no further steps were initiated by 27% of the primary care physicians and 22,7% of the surgeons , gynecologists or internists . Only 5% of the dermatologists misdiagnosed the lesions . In the second trial period from 1993 to 1995 in all physician groups the rate of misdiagnosis increased due to changes in heathcare services in the context of privatisation in our health care system in East Germany . Whereas 83,2% of the patients first evaluated by dermatologists had a surgical removal of the mole within the first 2 months after consultation , the proportion for those diagnosed by non-dermatologists was only 58,5% . The rate of primary treatment by surgeons , often with a small safety margin , also increased ."
],
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0,
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]
}
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},
{
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"normalized": []
},
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"arg2_id": "DerHautarzt.80490844.eng.abstr-s13-t6",
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},
{
"id": "DerHautarzt.80490844.eng.abstr-s13-r5-t6.1-t3.1",
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},
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"type": "conceptually_related_to",
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},
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"id": "DerHautarzt.80490844.eng.abstr-s13-r9-t10.1-t1.1",
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},
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"id": "DerHautarzt.80490844.eng.abstr-s13-r11-t8.1-t5.1",
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},
{
"id": "DerHautarzt.80490844.eng.abstr-s14-r4-t2.1-t1.1",
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] |
DerHautarzt.80490855.eng.abstr
|
DerHautarzt.80490855.eng.abstr
|
[
{
"id": "DerHautarzt.80490855.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 1986 Rongioletti introduced the term acral persistent papular mucinosis for persistent papules on the dorsum of the hands and distal forearms . Skin specimens reveal mucin deposits which resemble those in lichen myxedematosus ( LM ) . Laboratory results are usually unremarkable . Our 54-year-old female patient showed a 21/2 year history of skin lesions in the typical acral distribution pattern . This entity appears to be an acral papular subtype of LM . In the classification of LM , acral papular lichen myxedematosus should replace the discrete papular form . This latter form has been well known for many years , but is not sufficiently definable and is of secondary clinical importance ."
],
"offsets": [
[
0,
698
]
]
}
] |
[
{
"id": "DerHautarzt.80490855.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"mucinosis"
],
"offsets": [
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65,
74
]
],
"normalized": [
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"db_id": "C0162855"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"dorsum"
],
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[
105,
111
]
],
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{
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"db_id": "C0004600"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"hands"
],
"offsets": [
[
119,
124
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018563"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"forearms"
],
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[
136,
144
]
],
"normalized": [
{
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"db_id": "C0016536"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Skin"
],
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[
147,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"mucin"
],
"offsets": [
[
169,
174
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026682"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"lichen"
],
"offsets": [
[
208,
214
]
],
"normalized": [
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"db_id": "C0023657"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"myxedematosus"
],
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[
215,
228
]
],
"normalized": [
{
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"db_id": "C0027145"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Laboratory"
],
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[
238,
248
]
],
"normalized": [
{
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"db_id": "C0022877"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"female"
],
"offsets": [
[
300,
306
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086287"
},
{
"db_name": "UMLS",
"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
307,
314
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"history"
],
"offsets": [
[
334,
341
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019664"
},
{
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"db_id": "C0019665"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
345,
349
]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"distribution"
],
"offsets": [
[
379,
391
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520511"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"classification"
],
"offsets": [
[
468,
482
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008902"
},
{
"db_name": "UMLS",
"db_id": "C0008903"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"lichen"
],
"offsets": [
[
505,
511
]
],
"normalized": [
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}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"myxedematosus"
],
"offsets": [
[
512,
525
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"form"
],
"offsets": [
[
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585
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerHautarzt.80490855.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"secondary"
],
"offsets": [
[
667,
676
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027627"
},
{
"db_name": "UMLS",
"db_id": "C0036525"
}
]
}
] |
[] |
[] |
[
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},
{
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},
{
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"type": "adjacent_to",
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{
"id": "DerHautarzt.80490855.eng.abstr-s1-r5-t3.1-t1.1",
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{
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},
{
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r1-t4.1-t3.1",
"type": "affects",
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"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r2-t2.1-t4.1",
"type": "affects",
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"arg2_id": "DerHautarzt.80490855.eng.abstr-s4-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r3-t2.1-t1.1",
"type": "disrupts",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t2",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r4-t1.1-t3.1",
"type": "property_of",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r5-t4.1-t2.1",
"type": "produces",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r6-t4.1-t1.1",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r7-t1.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r8-t1.1-t3.1",
"type": "part_of",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r9-t3.1-t2.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.80490855.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r10-t1.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s4-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s2-r11-t1.1-t4.1",
"type": "location_of",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s4-t4",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r1-t1.1-t3.2",
"type": "uses",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r2-t3.2-t3.1",
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},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r3-t1.1-t3.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r4-t5.1-t3.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r5-t1.2-t3.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s4-r6-t3.2-t5.1",
"type": "isa",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.80490855.eng.abstr-s6-r1-t3.1-t1.2",
"type": "affects",
"arg1_id": "DerHautarzt.80490855.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.80490855.eng.abstr-s6-t1",
"normalized": []
}
] |
DerHautarzt.80490859.eng.abstr
|
DerHautarzt.80490859.eng.abstr
|
[
{
"id": "DerHautarzt.80490859.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 46-years old male patient suffered for several years from painful swelling of the distal soft tissues of the great toes associated with onychodystrophy . Mycological studies were negative . By means of radiological and scintigrafic examination and because of the typical clinical signs , the diagnosis of psoriatic onycho-pachydermo-periostitis of the great toes was established . The syndrome which is highly evocative of rheumatoid psoriasis was first discribed by Fournié and co-workers in 1989. Oral retinoids were helpful in diminishing both pain and soft tissue swelling of the great toes ."
],
"offsets": [
[
0,
598
]
]
}
] |
[
{
"id": "DerHautarzt.80490859.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
11,
14
]
],
"normalized": [
{
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.80490859.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
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[] |
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}
] |
DerHautarzt.80490895.eng.abstr
|
DerHautarzt.80490895.eng.abstr
|
[
{
"id": "DerHautarzt.80490895.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Shampooing is the most common form of hair treatment . Shampoos have primarily been products aimed at cleansing the hair and scalp . The diversity of qualities demanded from a good shampoo by today's consumer go far beyond this general function . A cosmetic benefit is expected , and the shampoo formulation has to be tailored to all the possible variations associated with hair quality ( dry , greasy , permed , bleached , dyed ) , age ( baby shampoo ) , care habit ( frequency of shampooing ) and specific problems relating to the superficial condition of the scalp ( dandruff , seborrhea ) . Selected ingredients of shampoos that have been popular with the consumer are currently under attack because of potential risks associated with their use ( e . g . halogenated organic compounds , formaldehyde , musk fragrances , and crude coal tar ) . Our standard graduate training programs devote limited attention to the subject of shampoos , and much of the readily available information concerning shampoos is supplied by the industry . We should be increasingly aware that our patients look to us to supply independent information on what can be expected from a shampoo to enable them to make more informed choices at the consumer level ."
],
"offsets": [
[
0,
1239
]
]
}
] |
[
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{
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"hair"
],
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[
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42
]
],
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"db_id": "C0018494"
}
]
},
{
"id": "DerHautarzt.80490895.eng.abstr-s1-t3",
"type": "umlsterm",
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"treatment"
],
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[
43,
52
]
],
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},
{
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"hair"
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120
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}
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},
{
"id": "DerHautarzt.80490895.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"scalp"
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125,
130
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DerHautarzt.80490902.eng.abstr
|
DerHautarzt.80490902.eng.abstr
|
[
{
"id": "DerHautarzt.80490902.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mechanisms for the increased Staphylococcus aureus colonization in atopic eczema are only partially known . From the aspect of the bacterium , the presence of various extracellular matrix components seems important . In the host epidermal lipid deficencies disturbing barrier dysfunction are important . Staphylococcus aureus ' immunological and inflammatory effects include the release of superantigens , additional exotoxins and exoenzymes and perhaps bacterial DNA-triggered mechanisms . Therapeutic possibilities include the use of systemic antibiotics in cases of generalized superinfected atopic eczema , the use of corticosteroids and specific antibiotic-antiseptic combinations in cases of localised superinfected atopic eczema and the wide-spread use of topical antiseptics in cases of microbial-laden atopic eczema ."
],
"offsets": [
[
0,
826
]
]
}
] |
[
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],
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29,
43
]
],
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},
{
"id": "DerHautarzt.80490902.eng.abstr-s1-t2",
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],
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80
]
],
"normalized": [
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},
{
"id": "DerHautarzt.80490902.eng.abstr-s1-t3",
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"text": [
"Staphylococcus aureus"
],
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[
29,
50
]
],
"normalized": [
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}
] |
DerHautarzt.80490907.eng.abstr
|
DerHautarzt.80490907.eng.abstr
|
[
{
"id": "DerHautarzt.80490907.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Helicobacter pylori infection has been assumed to be the underlying cause of some dermatological diseases such as , chronic urticaria . In order to investigate this problem we interviewed 55 patients with chronic urticaria concerning the state of the disease approximately 10 months after being discharged from hospital . After an additional six months we interviewed them for a second time and thus determined the remission ratio . There was no significant evidence showing that a link exists between urticaria and proven Helicobacter pylori infection ( 2-Test ) . There was also no significant correlation in the remission ratio between patients treated with a triple therapy and non-treated patients ( exact Fisher-Test ) ."
],
"offsets": [
[
0,
726
]
]
}
] |
[
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t1",
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"text": [
"Helicobacter"
],
"offsets": [
[
0,
12
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085508"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"pylori"
],
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[
13,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034196"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"infection"
],
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[
20,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cause"
],
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[
68,
73
]
],
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{
"db_name": "UMLS",
"db_id": "C0015127"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"diseases"
],
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97,
105
]
],
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{
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"urticaria"
],
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[
124,
133
]
],
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{
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"db_id": "C0042109"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"Helicobacter pylori"
],
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[
0,
19
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],
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s1-t8",
"type": "umlsterm",
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"dermatological diseases"
],
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82,
105
]
],
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s2-t1",
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"text": [
"patients"
],
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191,
199
]
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{
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"urticaria"
],
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[
213,
222
]
],
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{
"db_name": "UMLS",
"db_id": "C0042109"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"disease"
],
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251,
258
]
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{
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s2-t4",
"type": "umlsterm",
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"hospital"
],
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[
311,
319
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],
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{
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"db_id": "C0019994"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s3-t1",
"type": "umlsterm",
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"time"
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[
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390
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],
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"db_id": "C0040223"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"link"
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]
],
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"db_id": "C0208973"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"urticaria"
],
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502,
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]
],
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t3",
"type": "umlsterm",
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"proven"
],
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[
516,
522
]
],
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{
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"db_id": "C0700164"
}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"Helicobacter"
],
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523,
535
]
],
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t5",
"type": "umlsterm",
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"pylori"
],
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536,
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],
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t6",
"type": "umlsterm",
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"infection"
],
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543,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s4-t7",
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"Helicobacter pylori"
],
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523,
542
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],
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},
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"id": "DerHautarzt.80490907.eng.abstr-s5-t1",
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]
},
{
"id": "DerHautarzt.80490907.eng.abstr-s5-t2",
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"text": [
"therapy"
],
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670,
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"db_name": "UMLS",
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]
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{
"id": "DerHautarzt.80490907.eng.abstr-s5-t3",
"type": "umlsterm",
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],
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},
{
"id": "DerHautarzt.80490907.eng.abstr-s5-t4",
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},
{
"id": "DerHautarzt.80490907.eng.abstr-s5-t5",
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{
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}
] |
[] |
[] |
[
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] |
DerHautarzt.80490912.eng.abstr
|
DerHautarzt.80490912.eng.abstr
|
[
{
"id": "DerHautarzt.80490912.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The various noxious agents to which these occupational groups can be exposed are described in detail . We have constructed a supplementary questionnaire to aid the occupational dermatologist in evaluating such individuals . We describe measures for skin protection , and methods for reduce exposure to harmful agents ."
],
"offsets": [
[
0,
318
]
]
}
] |
[
{
"id": "DerHautarzt.80490912.eng.abstr-s1-t1",
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"occupational groups"
],
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{
"id": "DerHautarzt.80490912.eng.abstr-s3-t2",
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}
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{
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}
]
}
] |
[] |
[] |
[] |
DerHautarzt.80490920.eng.abstr
|
DerHautarzt.80490920.eng.abstr
|
[
{
"id": "DerHautarzt.80490920.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Still's disease was originally described as one form of rheumatoid arthritis in children beginning with fever and other systemic symptoms . In rare cases it may also begin in the adult and is then referred to as adult-onset Still's disease . The diagnostic criteria include typical rash , arthralgias , bouts of fever , and leukocytosis , as well as lymphadenopathy or splenomegaly , liver dysfunctions , non-infectious angina , and absence of rheumatoid factor and antinuclear antibodies . We report two adult patients with longstanding disease whose exanthema guided us to the correct diagnosis . The rash is a finding with high sensitivity . It is characterized by red macules with distinct borders and is evanescent . During an acute flare of the rash , gentle friction induces erythematous , isomorphic ( Koebner ) phenomena , which , as we describe here for the first time , may persist longer than the remainder of the fleeting rash ."
],
"offsets": [
[
0,
941
]
]
}
] |
[
{
"id": "DerHautarzt.80490920.eng.abstr-s1-t1",
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"Still's"
],
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]
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{
"id": "DerHautarzt.80490920.eng.abstr-s1-t2",
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"disease"
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]
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{
"id": "DerHautarzt.80490920.eng.abstr-s1-t3",
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{
"id": "DerHautarzt.80490920.eng.abstr-s1-t4",
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"id": "DerHautarzt.80490920.eng.abstr-s1-t6",
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{
"id": "DerHautarzt.80490920.eng.abstr-s1-t8",
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{
"id": "DerHautarzt.80490920.eng.abstr-s2-t1",
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{
"id": "DerHautarzt.80490920.eng.abstr-s2-t2",
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"id": "DerHautarzt.80490920.eng.abstr-s2-t3",
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"id": "DerHautarzt.80490920.eng.abstr-s3-t1",
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{
"id": "DerHautarzt.80490920.eng.abstr-s3-t3",
"type": "umlsterm",
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"rash"
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"db_id": "C0015230"
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},
{
"id": "DerHautarzt.80490920.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"arthralgias"
],
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{
"id": "DerHautarzt.80490920.eng.abstr-s3-t5",
"type": "umlsterm",
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"id": "DerHautarzt.80490920.eng.abstr-s3-t6",
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"id": "DerHautarzt.80490920.eng.abstr-s3-t7",
"type": "umlsterm",
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"id": "DerHautarzt.80490920.eng.abstr-s3-t8",
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"id": "DerHautarzt.80490920.eng.abstr-s3-t9",
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"db_id": "C0023884"
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] |
DerHautarzt.80490929.eng.abstr
|
DerHautarzt.80490929.eng.abstr
|
[
{
"id": "DerHautarzt.80490929.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Lichen ruber planus is considered a T-cell mediated immunologic reaction with unclear pathogenesis . Drugs and infections ( especially hepatitis B and C ) are well-known provocation factors . After an infection with scabies a 13 year old boy developed a generalized lichen planus including bullous lesions . For the first time scabies is presented as a trigger for lichen planus . In childhood , lichen planus is characterized by atypical clinical features and sometimes a severe course ."
],
"offsets": [
[
0,
488
]
]
}
] |
[
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t1",
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"text": [
"Lichen"
],
"offsets": [
[
0,
6
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023657"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"planus"
],
"offsets": [
[
13,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032074"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
36,
42
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"immunologic"
],
"offsets": [
[
52,
63
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205470"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"pathogenesis"
],
"offsets": [
[
86,
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]
],
"normalized": [
{
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"db_id": "C0543483"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"ruber planus"
],
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[
7,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023646"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"Lichen ruber planus"
],
"offsets": [
[
0,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023646"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Drugs"
],
"offsets": [
[
101,
106
]
],
"normalized": [
{
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"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"infections"
],
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[
111,
121
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"hepatitis"
],
"offsets": [
[
135,
144
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019158"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"hepatitis B"
],
"offsets": [
[
135,
146
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019163"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"infection"
],
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[
201,
210
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"scabies"
],
"offsets": [
[
216,
223
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
234,
237
]
],
"normalized": [
{
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"lichen"
],
"offsets": [
[
266,
272
]
],
"normalized": [
{
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"db_id": "C0023657"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"planus"
],
"offsets": [
[
273,
279
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032074"
}
]
},
{
"id": "DerHautarzt.80490929.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"lichen planus"
],
"offsets": [
[
266,
279
]
],
"normalized": [
{
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] |
[] |
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] |
DerHautarzt.80490932.eng.abstr
|
DerHautarzt.80490932.eng.abstr
|
[
{
"id": "DerHautarzt.80490932.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 24-year-old woman with lymph vessel dysplasia had experienced a progressive edema of her legs since her second year of life and progressive facial edema for the past year . She also had telangiectasias and papules on the background of a diffuse erythema as well as marked seborrhea on her face . Histopathological examination of a representative facial lesion revealed a granulomatous dermatitis with periadnexal distribution mainly consisting of lymphocytes and histiocytes . In addition , there was a moderate fibrosis of the dermis with numerous mast cells . By duplex ultrasound , a diagnosis of a massive edema of the legs without evidence for chronic venous insufficiency was made . The clinical and histopathological findings were consistent with solid persistent erythema and edema of the face associated with rosacea and lymph vessel dysplasia . The chronic course , absence of serological abnormalities and nonspecific histopathological features as well as resistance to therapy are the most important diagnostic cirteria of this disease also known as Morbihan's disease ."
],
"offsets": [
[
0,
1084
]
]
}
] |
[
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"lymph"
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{
"id": "DerHautarzt.80490932.eng.abstr-s1-t3",
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"id": "DerHautarzt.80490932.eng.abstr-s3-t4",
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"id": "DerHautarzt.80490932.eng.abstr-s4-t1",
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},
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"id": "DerHautarzt.80490932.eng.abstr-s7-r2-t1.1-t6.1",
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},
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},
{
"id": "DerHautarzt.80490932.eng.abstr-s7-r4-t3.1-t6.1",
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},
{
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},
{
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},
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},
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},
{
"id": "DerHautarzt.80490932.eng.abstr-s7-r13-t6.1-t3.1",
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"id": "DerHautarzt.80490932.eng.abstr-s7-r14-t1.1-t3.1",
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}
] |
DerHautarzt.90500005.eng.abstr
|
DerHautarzt.90500005.eng.abstr
|
[
{
"id": "DerHautarzt.90500005.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Melatonin ( N-acetyl-5-methoxytryptamine) is a hormone with multiple functions in humans , produced by the pineal gland and stimulated by -adrenergic receptors . Serum melatonin levels exhibit a circadian rhythm with low levels during the day , rise in the evening and maximum levels at night between 2 and 4 a.m. . Melatonin participates in the regulation of several physiological processes such as seasonal biological rhythm , daily sleep induction , aging and modulation of immunobiological defence reactions . Furthermore , melatonin has a highly lipophilic molecular structure facilitating penetration of cell membranes and serving as an extra- and intracellular free radical scavenger . Melatonin seems to quench mainly hydroxyl radicals , the most damaging of all free radicals . Melatonin may play a role in the etiology and treatment of several dermatoses e.g. atopic eczema , psoriasis and malignant melanoma . The influence of melatonin on hair growth is another aspect . Topical application of melatonin inhibits the development of UV-erythema . Penetration through skin after topical application and oral bioavailability auxit further investigations on the pharmacokinetic and pharmacodynamic actions of melatonin ."
],
"offsets": [
[
0,
1228
]
]
}
] |
[
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"id": "DerHautarzt.90500005.eng.abstr-s1-t1",
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0,
9
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}
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t2",
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"id": "DerHautarzt.90500005.eng.abstr-s1-t3",
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"functions"
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}
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t4",
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"humans"
],
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82,
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]
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{
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t5",
"type": "umlsterm",
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"pineal"
],
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]
],
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{
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"db_id": "C0031939"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"-adrenergic"
],
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138,
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]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"pineal gland"
],
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107,
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]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-t8",
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"-adrenergic receptors"
],
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138,
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"db_id": "C0034783"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"melatonin"
],
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168,
177
]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"exhibit"
],
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185,
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],
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"db_id": "C0015272"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"circadian rhythm"
],
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195,
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]
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"db_id": "C0008810"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s3-t1",
"type": "umlsterm",
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"Melatonin"
],
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316,
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],
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"regulation"
],
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]
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"db_id": "C0034982"
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"db_id": "C0220905"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"sleep"
],
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[
435,
440
]
],
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{
"db_name": "UMLS",
"db_id": "C0037313"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"physiological processes"
],
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368,
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]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"melatonin"
],
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528,
537
]
],
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}
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"cell"
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]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"membranes"
],
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]
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"db_id": "C0025255"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"molecular structure"
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"db_id": "C0026383"
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{
"id": "DerHautarzt.90500005.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"cell membranes"
],
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610,
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],
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"db_id": "C0007603"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"free radical"
],
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]
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"db_id": "C0016693"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s4-t7",
"type": "umlsterm",
"text": [
"free radical scavenger"
],
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"db_id": "C0079381"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Melatonin"
],
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693,
702
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],
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"hydroxyl"
],
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]
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"db_id": "C0063146"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"hydroxyl radicals"
],
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726,
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]
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s5-t4",
"type": "umlsterm",
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"free radicals"
],
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],
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"db_id": "C0016693"
}
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t1",
"type": "umlsterm",
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"Melatonin"
],
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}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"role"
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]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t3",
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"text": [
"etiology"
],
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820,
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"db_id": "C0015127"
},
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"db_id": "C0007463"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t4",
"type": "umlsterm",
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"dermatoses"
],
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]
],
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"db_id": "C0037274"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"eczema"
],
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[
877,
883
]
],
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"db_id": "C0013595"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t7",
"type": "umlsterm",
"text": [
"psoriasis"
],
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886,
895
]
],
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"db_name": "UMLS",
"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t8",
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"text": [
"malignant"
],
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900,
909
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],
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"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t9",
"type": "umlsterm",
"text": [
"melanoma"
],
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910,
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]
},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t10",
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"text": [
"atopic eczema"
],
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],
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s6-t11",
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900,
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},
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s7-t2",
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]
},
{
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]
},
{
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},
{
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]
},
{
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"skin"
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},
{
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]
},
{
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]
},
{
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"type": "umlsterm",
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"melatonin"
],
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],
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{
"db_name": "UMLS",
"db_id": "C0025219"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500005.eng.abstr-s1-r1-t3.1-t4.1",
"type": "affects",
"arg1_id": "DerHautarzt.90500005.eng.abstr-s9-t3",
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-r2-t7.1-t1.1",
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-r3-t7.1-t8.1",
"type": "produces",
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"arg2_id": "DerHautarzt.90500005.eng.abstr-s6-t8",
"normalized": []
},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-r4-t6.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500005.eng.abstr-s6-t6",
"arg2_id": "DerHautarzt.90500005.eng.abstr-s9-t1",
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},
{
"id": "DerHautarzt.90500005.eng.abstr-s1-r5-t1.1-t3.1",
"type": "affects",
"arg1_id": "DerHautarzt.90500005.eng.abstr-s9-t1",
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"normalized": []
},
{
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DerHautarzt.90500012.eng.abstr
|
DerHautarzt.90500012.eng.abstr
|
[
{
"id": "DerHautarzt.90500012.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In recent years the investigation of cytokines has been a focus of scientific interest in order to understand the pathogenesis of a variety of diseases . In additions cytokines are increasingly being used for therapeutic purposes , including dermatologic disorders . IL-10 is a recently described cytokine with anti- inflammatory and immunosuppressive qualities which plays an important role in immunoregulation . The overexpression of this mediator has been proven in some inflammatory dermatoses as well as in various skin tumors . These observations help to understand down regulatory events in hyperinflammatory conditions such as allergic or toxic dermatitis on the one hand and the suppression of an adequate anti-tumor response and thereby the progression of malignant tumors on the other hand . Recent investigations indicate a relative IL-10 deficiency in psoriasis . Initial therapeutic applications of IL-10 in psoriasis underline the pathophysiological importance of this cytokine ."
],
"offsets": [
[
0,
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]
]
}
] |
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}
] |
DerHautarzt.90500020.eng.abstr
|
DerHautarzt.90500020.eng.abstr
|
[
{
"id": "DerHautarzt.90500020.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Due to its high prevalence , atopic dermatitis is an important problem in the dermatologic practice . The chronicity of the disease together with numerous triggering factors of varying individual impact create a complex situation which is difficult to manage under the current circumstances in our health care system . We describe the concept of an outpatient clinic especially for atopic dermatitis as established in our Department of Dermatology . A high degree of standardization is combined with a high measure of individual care . The aims of this clinic are an optimized outpatient management of atopic dermatitis , the gathering of epidemiologic data , the performance of controlled studies , and potentially the reduction of costs ."
],
"offsets": [
[
0,
740
]
]
}
] |
[
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],
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]
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},
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}
]
},
{
"id": "DerHautarzt.90500020.eng.abstr-s1-t2",
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"dermatitis"
],
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36,
46
]
],
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]
},
{
"id": "DerHautarzt.90500020.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"atopic dermatitis"
],
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29,
46
]
],
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}
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},
{
"id": "DerHautarzt.90500020.eng.abstr-s2-t1",
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"health"
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},
{
"id": "DerHautarzt.90500020.eng.abstr-s2-t4",
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"triggering factors"
],
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"id": "DerHautarzt.90500020.eng.abstr-s3-t1",
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"outpatient"
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"id": "DerHautarzt.90500020.eng.abstr-s3-t2",
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]
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}
] |
[] |
[] |
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] |
DerHautarzt.90500027.eng.abstr
|
DerHautarzt.90500027.eng.abstr
|
[
{
"id": "DerHautarzt.90500027.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) ."
],
"offsets": [
[
0,
1812
]
]
}
] |
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DerHautarzt.90500034.eng.abstr
|
DerHautarzt.90500034.eng.abstr
|
[
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"id": "DerHautarzt.90500034.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The treatment of choice for prevention of recurrent erysipelas is the long-term therapy with intramuscular penicillin . The results are often unsatisfactory . Usually erysipelas recurs when the treatment is stopped . The aim of the present study was to evaluate a new treatment regimen , consisting of intravenous penicillin combined with lymphatic drainage . Fifteen patients who had suffered from three or more episodes of erysipelas within the last two years received 10 Mega I.U. of penicillin per day over ten days every third month over a one year period ( patients who were allergic to penicillin received erythromycin ) . Use of intravenous penicillin was combined with lymphatic drainage performed by a sequential pneumatic compressing device . The treatment results were assessed by clinical examination and laboratory tests as well as by laser Doppler imaging every third month . During the one year treatment period and a further year of follow-up , 14 of 15 patients had no recurrent erysipelas . Only a 65 year old patient suffering from Parkinson heart failure , chronic lymphedema and an extensive stasis ulcers had recurrent erysipelas . The present treatment regimen appears to be an effective therapy for prevention of recurrent erysipelas ."
],
"offsets": [
[
0,
1260
]
]
}
] |
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DerHautarzt.90500039.eng.abstr
|
DerHautarzt.90500039.eng.abstr
|
[
{
"id": "DerHautarzt.90500039.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Unilateral laterothoracic exanthem a ( ULE ) is a self-limited , probably infectious-allergic skin disease predominately affecting small children . We describe five such cases . The typical unilaterally located or at least unilaterally dominant exanthem usually starts in the axillary region and is characterized by red , partly confluent papules and fine scales . Two of the children presented with atypical manifestations of ULE . Due to its asymptomatic course , therapy is not necessary in the majority of cases ."
],
"offsets": [
[
0,
517
]
]
}
] |
[
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t1",
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"exanthem"
],
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[
26,
34
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015230"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t2",
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"text": [
"self-limited"
],
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50,
62
]
],
"normalized": [
{
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"db_id": "C0036588"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
94,
98
]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
99,
106
]
],
"normalized": [
{
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"children"
],
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[
137,
145
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"skin disease"
],
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[
94,
106
]
],
"normalized": [
{
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"db_id": "C0037274"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"exanthem"
],
"offsets": [
[
245,
253
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015230"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"scales"
],
"offsets": [
[
356,
362
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0175659"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"children"
],
"offsets": [
[
376,
384
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008059"
}
]
},
{
"id": "DerHautarzt.90500039.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"therapy"
],
"offsets": [
[
466,
473
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
}
] |
[] |
[] |
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DerHautarzt.90500047.eng.abstr
|
DerHautarzt.90500047.eng.abstr
|
[
{
"id": "DerHautarzt.90500047.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 58 year old patient with hepatitis virus C ( HCV ) infection had a secondary polyclonal IgG-IgM cryoglobulinemia with a benign 20 year course . Clincally the patient suffered from progressive pigmented purpura ( PPP ) . Histologic evaluation revealed a lymphocytic vasculitis . Food containing tartrazine trig- gered flares of the PPP , as demonstrated with controlled oral provocation testing . In most of the previously described cases of HCV and type III cryoglobulinemia , the typical cutaneus finding was palpable purpura with leukocytoclastic vasculitis ."
],
"offsets": [
[
0,
563
]
]
}
] |
[
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t3",
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"text": [
"hepatitis"
],
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27,
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],
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"db_id": "C0019158"
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t4",
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"virus"
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t5",
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"text": [
"HCV"
],
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47,
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]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t6",
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"infection"
],
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[
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62
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],
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"db_id": "C0021311"
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},
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"id": "DerHautarzt.90500047.eng.abstr-s1-t7",
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"secondary"
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]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t8",
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],
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],
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"db_id": "C0010403"
}
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s1-t9",
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"text": [
"hepatitis virus"
],
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[
27,
42
]
],
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"db_id": "C0019186"
}
]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
160,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"purpura"
],
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[
204,
211
]
],
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"db_id": "C0034150"
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Histologic"
],
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222,
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{
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s3-t2",
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"evaluation"
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}
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s3-t3",
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"text": [
"vasculitis"
],
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267,
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],
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]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Food"
],
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[
280,
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],
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"db_id": "C0016452"
}
]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"tartrazine"
],
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296,
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],
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"db_id": "C0039329"
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},
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"id": "DerHautarzt.90500047.eng.abstr-s4-t3",
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},
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"id": "DerHautarzt.90500047.eng.abstr-s5-t1",
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"HCV"
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]
},
{
"id": "DerHautarzt.90500047.eng.abstr-s5-t2",
"type": "umlsterm",
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"cryoglobulinemia"
],
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"id": "DerHautarzt.90500047.eng.abstr-s5-t3",
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{
"id": "DerHautarzt.90500047.eng.abstr-s5-t4",
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},
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"id": "DerHautarzt.90500047.eng.abstr-s5-t5",
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"vasculitis"
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}
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},
{
"id": "DerHautarzt.90500047.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"leukocytoclastic vasculitis"
],
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[
534,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0151436"
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]
}
] |
[] |
[] |
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{
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{
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] |
DerHautarzt.90500052.eng.abstr
|
DerHautarzt.90500052.eng.abstr
|
[
{
"id": "DerHautarzt.90500052.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cutaneous adverse drug reactions in HIV-positive patients with their wide spectrum of manifestations remain a diagnostic and therapeutic challenge . Skin diseases as erythema multiforme , Stevens-Johnson syndrome and toxic epidermal necrolysis belong to this group . The typical primary lesions are erythematous macules and papules , which rapidly extend to the entire body and may be accompained by a extensive epidermal detachment . Diagnosis and immediate therapy is indispensable because of the possible fulminant course of the disease . We report a HIV-positive patient with a cutaneous adverse drug reaction showing predominantly hemorrhagic lesions ."
],
"offsets": [
[
0,
657
]
]
}
] |
[
{
"id": "DerHautarzt.90500052.eng.abstr-s1-t1",
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"drug"
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18,
22
]
],
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}
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},
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"id": "DerHautarzt.90500052.eng.abstr-s1-t2",
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"patients"
],
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49,
57
]
],
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{
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}
]
},
{
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"diagnostic"
],
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],
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}
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},
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"id": "DerHautarzt.90500052.eng.abstr-s1-t4",
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"text": [
"therapeutic"
],
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125,
136
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t1",
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"Skin"
],
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[
149,
153
]
],
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{
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"db_id": "C0037267"
}
]
},
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"id": "DerHautarzt.90500052.eng.abstr-s2-t2",
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"diseases"
],
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154,
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]
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{
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]
},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"erythema"
],
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166,
174
]
],
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},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t4",
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},
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"id": "DerHautarzt.90500052.eng.abstr-s2-t5",
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"toxic"
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217,
222
]
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{
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"db_id": "C0600688"
}
]
},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"Skin diseases"
],
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[
149,
162
]
],
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{
"db_name": "UMLS",
"db_id": "C0037274"
}
]
},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t7",
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"erythema multiforme"
],
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166,
185
]
],
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}
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},
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"id": "DerHautarzt.90500052.eng.abstr-s2-t8",
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],
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188,
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],
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}
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},
{
"id": "DerHautarzt.90500052.eng.abstr-s2-t9",
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],
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},
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"id": "DerHautarzt.90500052.eng.abstr-s4-t3",
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{
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}
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}
] |
[] |
[] |
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},
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{
"id": "DerHautarzt.90500052.eng.abstr-s4-r5-t1.2-t1.1",
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] |
DerHautarzt.90500091.eng.abstr
|
DerHautarzt.90500091.eng.abstr
|
[
{
"id": "DerHautarzt.90500091.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In contrast to conventional antigens , bacterial superantigens activate a large percentage of an organism's total T-cell repertoire . This has clinical implications particularly in the case of infections with Gram-positive bacteria . Unravelling the molecular mechanisms of superantigen-mediated T-cell activation has yielded new insights in the pathogenesis of a number of diseases , in the field of dermatology namely atopic dermatitis and psoriasis . Moreover , therapeutic applications of superantigens have begun to emerge ."
],
"offsets": [
[
0,
529
]
]
}
] |
[
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t1",
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"contrast"
],
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[
3,
11
]
],
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t2",
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"antigens"
],
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28,
36
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t3",
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"text": [
"bacterial"
],
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[
39,
48
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t4",
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"text": [
"superantigens"
],
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[
49,
62
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t5",
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"text": [
"organism's"
],
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97,
107
]
],
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}
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{
"id": "DerHautarzt.90500091.eng.abstr-s1-t6",
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"organism's"
],
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[
97,
107
]
],
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{
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"db_id": "C0605770"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
114,
120
]
],
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"infections"
],
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[
193,
203
]
],
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{
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"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"bacteria"
],
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[
223,
231
]
],
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{
"db_name": "UMLS",
"db_id": "C0004611"
},
{
"db_name": "UMLS",
"db_id": "C0521009"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"Gram-positive bacteria"
],
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[
209,
231
]
],
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{
"db_name": "UMLS",
"db_id": "C0018154"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
296,
302
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"pathogenesis"
],
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[
346,
358
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"diseases"
],
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374,
382
]
],
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"dermatology"
],
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[
401,
412
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"dermatitis"
],
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[
427,
437
]
],
"normalized": [
{
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"db_id": "C0011603"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"psoriasis"
],
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[
442,
451
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"atopic dermatitis"
],
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[
420,
437
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011615"
}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
465,
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],
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{
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}
]
},
{
"id": "DerHautarzt.90500091.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"superantigens"
],
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[
493,
506
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206527"
}
]
}
] |
[] |
[] |
[
{
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r2-t6.1-t3.1",
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r3-t5.1-t6.1",
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r4-t1.1-t6.1",
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},
{
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r6-t6.1-t1.1",
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r7-t1.1-t5.1",
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},
{
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"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r9-t1.1-t5.1",
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"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r10-t3.1-t6.1",
"type": "interacts_with",
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"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r11-t5.1-t3.1",
"type": "produces",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r12-t3.1-t5.1",
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"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r13-t5.1-t1.1",
"type": "interacts_with",
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"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r14-t5.1-t1.1",
"type": "produces",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s1-r15-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-r1-t1.1-t2.1",
"type": "affects",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-r2-t2.2-t1.1",
"type": "causes",
"arg1_id": "DerHautarzt.90500091.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-r3-t2.1-t1.1",
"type": "causes",
"arg1_id": "DerHautarzt.90500091.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s2-r4-t1.1-t2.2",
"type": "affects",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r1-t1.1-t4.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t4",
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r2-t1.1-t6.1",
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},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r3-t2.1-t4.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r4-t1.1-t5.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r5-t1.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500091.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500091.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500091.eng.abstr-s3-r6-t1.1-t7.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.90500091.eng.abstr-s3-t7",
"normalized": []
}
] |
DerHautarzt.90500103.eng.abstr
|
DerHautarzt.90500103.eng.abstr
|
[
{
"id": "DerHautarzt.90500103.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract Stage IV melanoma is still a disease with poor prognosis . Although modern chemo- or chemoimmunotherapies give high response rates in stage IV patients , remissions are usually followed by fast relapses . In order to avoid early relapses after chemotherapy , patients with stage IV disease and either stable disease or partial or complete remission following therapy were treated with 9 million IU IFN subcutaneously 5 times weekly and 6 million IU IL-2 subcutaneously twice weekly . Compared with untreated controls , the rate of progression in the treatment group was reduced from 95% to 35% . Also , time to progression was significantly prolonged . Median survival times in the control group were 25 weeks , whereas median survival time in the treatment group has not yet been reached . Furthermore , TNF-ELISPOT assays showed a significant increase in MAGE-3 reactive cytotoxic T-cells in the treatment , but not in the control group . Thus , immunotherapy in stage IV disease seems to prolong survival in melanoma patients ."
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] |
DerHautarzt.90500109.eng.abstr
|
DerHautarzt.90500109.eng.abstr
|
[
{
"id": "DerHautarzt.90500109.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Therapy of the heterogenous group of primary cutaneous B- and T-cell lymphomas is based upon type of lymphoma and its staging . Treatment , especially for rare forms , has not yet been standardised . Two patients with uncommon primary cutaneous T-cell lymphomas received both traditional therapy and topical photodynamic therapy ( PDT ) in areas that are difficult to reach with classic methods ( ear , eyebrow , side of foot ) . The first patient had a rare type of medium/large cell pleomorphic , CD8-positive, CD30-negative, primary cutaneous T-cell lymphoma with primary involvement of the ear . As the tumor progressed during PUVA , interferon and retinoid therapy , topical PDT was employed . A histologically confirmed partial remission was obtained . As the disease further evolved the patient received radiotherapy and has now been in complete remission for 10 months . The other patient preserted with the classical picture of mycosis fungoides in initial tumour stage . This patient received in addition to PUVA therapy and interferon , topical PDT to the eyebrow and side of the foot . A complete remission was achieved and histologically confirmed . In the palliative treatment of cutaneous T-cell lymphoma , PDT is a new experimental method , especially for problem locations . It is tissue sparing , has few side effects , can be repeated as often as necessary and achieves good cosmetic results ."
],
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[
0,
1412
]
]
}
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DerHautarzt.90500115.eng.abstr
|
DerHautarzt.90500115.eng.abstr
|
[
{
"id": "DerHautarzt.90500115.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Perforating disorders represent a heterogenous group of dermatoses characterized by transepithelial elimination of dermal structures . Primary perforating disorders should be distinguished from secondary perforating disorders in which perforation with transepithelial elimination is a rare component of a variety of dermatoses . The primary perforating disorders are hyperkeratosis follicularis et parafollicularis in cutem penetrans ( Kyrle's disease ) , elastosis perforans serpiginosa and perforating folliculitis . Acquired reactive perforating dermatosis ( also known as acquired reactive perforating collagenosis ) together with the hereditary variant of the reactive perforating collagenosis represent further examples of the primary perforating disorders . We report on 84 year old and 96 year old female patients with an acquired perforating dermatosis . Both of the patients additionally showed diabetes and hyperuricemia . Oral administration of allopurinol ( 100 mg daily ) led to a healing of the disseminated skin lesions in 1-2 weeks . After a follow-up period of 6 months , both patients were in complete remission . On one hand , these results prove again the existence and the severity of this disease , and on the other hand suggest an immunomodulating or differentiation-promoting action in addition to the uricostatic effect of allopurinol ."
],
"offsets": [
[
0,
1362
]
]
}
] |
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12,
21
]
],
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s1-t2",
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],
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],
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},
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"id": "DerHautarzt.90500115.eng.abstr-s7-r5-t4.1-t1.1",
"type": "uses",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r1-t4.1-t2.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r2-t1.1-t4.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r3-t4.1-t3.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r4-t3.1-t2.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r5-t4.1-t1.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r6-t1.1-t2.1",
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},
{
"id": "DerHautarzt.90500115.eng.abstr-s9-r7-t4.1-t2.1",
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},
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"id": "DerHautarzt.90500115.eng.abstr-s9-r8-t3.1-t4.1",
"type": "produces",
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"normalized": []
}
] |
DerHautarzt.90500121.eng.abstr
|
DerHautarzt.90500121.eng.abstr
|
[
{
"id": "DerHautarzt.90500121.eng.abstr-passage-0",
"type": "abstract",
"text": [
"DNA-based prenatal testing of the fetal genotype was performed in a family at risk for recurrence of recessive dystrophic epidermolysis bullosa ( RDEB ) . DNA from cultured fibroblasts and leukocytes from the peripheral blood of the previously affected offspring , DNA from parental leukocytes and DNA from fetal tissue obtained by chorionic villus biopsy was analysed by direct PCR amplification of known polymorphic regions within or flanking the type VII collagen gene , the canditate gene in RDEB . One flanking marker ( D3S2/MspI) as well as two intragenic polymorphisms ( C7/MspI, C7/Eco0109I) in exons 30 and 84 were informative in this family . Thus , based on the haplotype analysis and the lack of evidence for locus heterogeneity in RDEB , a phenotypically healthy child was predicted . This prediction was confirmed by the birth of a healthy female infant . The study reports successful determination of the fetal genotype by PCR-based prenatal diagnosis in a family at risk for recurrence of severe RDEB ."
],
"offsets": [
[
0,
1018
]
]
}
] |
[
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t1",
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"testing"
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19,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"genotype"
],
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]
],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t3",
"type": "umlsterm",
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"family"
],
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[
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]
],
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"db_id": "C0015576"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"risk"
],
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78,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"recurrence"
],
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87,
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],
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"db_id": "C0034897"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"epidermolysis bullosa"
],
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[
122,
143
]
],
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"db_name": "UMLS",
"db_id": "C0014527"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"dystrophic epidermolysis bullosa"
],
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[
111,
143
]
],
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{
"db_name": "UMLS",
"db_id": "C0079294"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"DNA"
],
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[
155,
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]
],
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"db_id": "C0012854"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"fibroblasts"
],
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[
173,
184
]
],
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{
"db_name": "UMLS",
"db_id": "C0016030"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"leukocytes"
],
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[
189,
199
]
],
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{
"db_name": "UMLS",
"db_id": "C0023516"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"blood"
],
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220,
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]
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{
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},
{
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"db_id": "C0005835"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t5",
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"DNA"
],
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265,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t6",
"type": "umlsterm",
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"leukocytes"
],
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283,
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t7",
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"DNA"
],
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298,
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]
],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"tissue"
],
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[
313,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"biopsy"
],
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[
349,
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]
],
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{
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"db_id": "C0220797"
},
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]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t10",
"type": "umlsterm",
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t11",
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"PCR"
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t12",
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"collagen"
],
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}
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t13",
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"gene"
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],
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}
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t14",
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"gene"
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t15",
"type": "umlsterm",
"text": [
"fetal tissue"
],
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307,
319
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t16",
"type": "umlsterm",
"text": [
"chorionic villus"
],
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332,
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],
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}
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t17",
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"chorionic villus biopsy"
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332,
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],
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"db_id": "C0008509"
}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s2-t18",
"type": "umlsterm",
"text": [
"type VII collagen"
],
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449,
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s3-t1",
"type": "umlsterm",
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"polymorphisms"
],
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562,
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s3-t3",
"type": "umlsterm",
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"exons"
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],
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}
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s3-t4",
"type": "umlsterm",
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"family"
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]
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s4-t1",
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"text": [
"haplotype"
],
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s4-t2",
"type": "umlsterm",
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s4-t3",
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"text": [
"heterogeneity"
],
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727,
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]
],
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]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s4-t4",
"type": "umlsterm",
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],
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}
]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s5-t1",
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"text": [
"birth"
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]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"female"
],
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854,
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],
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]
},
{
"id": "DerHautarzt.90500121.eng.abstr-s5-t3",
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"infant"
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s6-t7",
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{
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"db_id": "C0033053"
}
]
}
] |
[] |
[] |
[
{
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},
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},
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-r5-t6.1-t3.1",
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},
{
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},
{
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"type": "result_of",
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-r8-t7.1-t3.1",
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},
{
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},
{
"id": "DerHautarzt.90500121.eng.abstr-s1-r10-t1.1-t5.1",
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] |
DerHautarzt.90500127.eng.abstr
|
DerHautarzt.90500127.eng.abstr
|
[
{
"id": "DerHautarzt.90500127.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pseudoscabies , i.e. infestation of human skin with animal mites may occasionally occur and should be considered in the differential diagnosis of pruritic and papular skin disease . We report here on a 52-year-old woman with pseudoscabies or canine scabies ( Sarcoptes scabiei var . canis ) , transmitted by indirect contact with a red fox in the urban area of Berlin . Red foxes may live in unhabited areas of metropolitan large cities , i.e. in garages , car wrecks and cellars . Full remission of the prolonged and pruritic rush was seen after topical administration of lindane together with systemic corticosteroids ."
],
"offsets": [
[
0,
621
]
]
}
] |
[
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Pseudoscabies"
],
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[
0,
13
]
],
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{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"human"
],
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[
36,
41
]
],
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{
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"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
42,
46
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"animal"
],
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[
52,
58
]
],
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{
"db_name": "UMLS",
"db_id": "C0003043"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"mites"
],
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[
59,
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]
],
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{
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"db_id": "C0026229"
},
{
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"db_id": "C0026231"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t6",
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"text": [
"diagnosis"
],
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133,
142
]
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"db_id": "C0011900"
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"skin"
],
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[
167,
171
]
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"disease"
],
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[
172,
179
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"db_id": "C0012634"
}
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
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[
120,
142
]
],
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{
"db_name": "UMLS",
"db_id": "C0220820"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"skin disease"
],
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[
167,
179
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s2-t1",
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"woman"
],
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214,
219
]
],
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}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"pseudoscabies"
],
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[
225,
238
]
],
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]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s2-t3",
"type": "umlsterm",
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"canine"
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[
242,
248
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],
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"db_id": "C0012984"
}
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"scabies"
],
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249,
256
]
],
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]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s2-t5",
"type": "umlsterm",
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"Sarcoptes scabiei"
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259,
276
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],
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"db_id": "C0036227"
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"canis"
],
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283,
288
]
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"db_id": "C0524516"
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"fox"
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336,
339
]
],
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{
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"db_id": "C0016633"
}
]
},
{
"id": "DerHautarzt.90500127.eng.abstr-s3-t3",
"type": "umlsterm",
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"Berlin"
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s4-t1",
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"foxes"
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"id": "DerHautarzt.90500127.eng.abstr-s4-t2",
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},
{
"id": "DerHautarzt.90500127.eng.abstr-s4-t3",
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"car"
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{
"id": "DerHautarzt.90500127.eng.abstr-s5-t1",
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] |
[] |
[] |
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DerHautarzt.90500165.eng.abstr
|
DerHautarzt.90500165.eng.abstr
|
[
{
"id": "DerHautarzt.90500165.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Androgenetic alopecia is the most common form of hair loss in men and women . Although clinically different , the pathogenetic pathways leading to this type of hair loss are similar in both sexes . Recent experimental data enable us to explain some pathogenetic steps suggesting a pivotal role of type 2 5-reductase in the pathogenesis of androgenetic hair loss . In this review our current knowledge about the pathophysiology and treatment options of androgenetic alopecia is summarized ."
],
"offsets": [
[
0,
489
]
]
}
] |
[
{
"id": "DerHautarzt.90500165.eng.abstr-s1-t1",
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"alopecia"
],
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13,
21
]
],
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}
]
},
{
"id": "DerHautarzt.90500165.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
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],
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41,
45
]
],
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] |
[] |
[] |
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] |
DerHautarzt.90500174.eng.abstr
|
DerHautarzt.90500174.eng.abstr
|
[
{
"id": "DerHautarzt.90500174.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a retrospective study 47 patients with 68 amateur and 25 professional tattoos were examined , considering clearance of tattoo pigments and the frequency of side effects after finished treatments with the Q-switched ruby ( 694 nm ) and the Q-switched Nd : YAG laser ( 532 and 1064 nm ) . Black amateur tattoos were found to lighten faster than professional tattoos ( 13,2 and 18,6 treatments respectively ) . For the clearance of multicolored tattoos ( amateur or professional ) , similar numbers of laser treatments were needed . Green pigments were removed with the Q-switched ruby laser and red pigments with the frequency-doubled Nd : YAG laser ( 532 nm ) . Compared to the Q-switched Nd : YAG laser ( 1064 nm ) , the Q-switched ruby laser and the frequency-doubled Nd : YAG laser ( 532 nm ) more often caused blistering and transient hypopigmentation ( 5,4% and 7,5% vs. 1,1% ( blisters ) ; 8.6% and 15.1% vs. 4.3% ( hypopigmentation ) ) ."
],
"offsets": [
[
0,
946
]
]
}
] |
[
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"patients"
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{
"id": "DerHautarzt.90500174.eng.abstr-s1-t3",
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"text": [
"tattoos"
],
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73,
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{
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"pigments"
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"frequency"
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DerHautarzt.90500181.eng.abstr
|
DerHautarzt.90500181.eng.abstr
|
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"id": "DerHautarzt.90500181.eng.abstr-passage-0",
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"Many different therapeutic approaches are employed to treat small vessels on the leg . In recent years a variety of lasers ( argon , Neodymium : YAG and dye lasers ) have been used as well as sclerotherapy , cryosurgery and electrosurgery . None of these lasers are entirely satisfactory , and there are a number of side effects . Because of its special physical characteristics , the newly developed long-pulsed frequency-doubled neodymium : YAG laser has clear advantages in the treatment of vascular lesions compared to other laser systems . These include : no vessel rupture compared to dye laser , no epidermal lesions compared to argon laser . In clinical tests it shows a high rate of effectiveness with minimal side effects ."
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[] |
[] |
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DerHautarzt.90500186.eng.abstr
|
DerHautarzt.90500186.eng.abstr
|
[
{
"id": "DerHautarzt.90500186.eng.abstr-passage-0",
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"545 male patients with a tentative diagnosis \" urethritis \" were examined between November 1984 and December 1994 in the Department of Dermatology and Venerology of the Military Hospital in Ulm . The patients , aged from 18 to 58 years ( mean age 24.1 years ) , were examined according to a standardized diagnostic procedure : ..."
],
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0,
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]
}
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}
] |
[] |
[] |
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"id": "DerHautarzt.90500186.eng.abstr-s1-r42-t3.2-t3.1",
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},
{
"id": "DerHautarzt.90500186.eng.abstr-s1-r43-t1.2-t1.1",
"type": "interacts_with",
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},
{
"id": "DerHautarzt.90500186.eng.abstr-s1-r44-t1.2-t8.1",
"type": "uses",
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},
{
"id": "DerHautarzt.90500186.eng.abstr-s2-r1-t1.1-t4.2",
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{
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},
{
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},
{
"id": "DerHautarzt.90500186.eng.abstr-s2-r5-t4.1-t2.2",
"type": "measurement_of",
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},
{
"id": "DerHautarzt.90500186.eng.abstr-s2-r6-t1.1-t2.1",
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}
] |
DerHautarzt.90500198.eng.abstr
|
DerHautarzt.90500198.eng.abstr
|
[
{
"id": "DerHautarzt.90500198.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 59-year-old Caucasian man suffered from persistent disseminated necrolytic skin lesions for 8 months . They failed to respond to a variety of therapeutic regimens but then cleared spontaneously within a few days . After one week an invasive squamous cell carcinoma of the hypopharynx became clinically apparent . At autopsy , the expected glucagonoma often associated with necrolytic migratory erythema was not found ."
],
"offsets": [
[
0,
420
]
]
}
] |
[
{
"id": "DerHautarzt.90500198.eng.abstr-s1-t1",
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"text": [
"Caucasian"
],
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14,
23
]
],
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}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"man"
],
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24,
27
]
],
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"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
77,
81
]
],
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{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
144,
155
]
],
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{
"db_name": "UMLS",
"db_id": "C0039796"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"cell"
],
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[
252,
256
]
],
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{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"carcinoma"
],
"offsets": [
[
257,
266
]
],
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{
"db_name": "UMLS",
"db_id": "C0007097"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"hypopharynx"
],
"offsets": [
[
274,
285
]
],
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{
"db_name": "UMLS",
"db_id": "C0153398"
},
{
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"db_id": "C0020629"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"squamous cell carcinoma"
],
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[
243,
266
]
],
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{
"db_name": "UMLS",
"db_id": "C0007137"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"autopsy"
],
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[
318,
325
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004398"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"glucagonoma"
],
"offsets": [
[
341,
352
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017689"
}
]
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"erythema"
],
"offsets": [
[
396,
404
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041834"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r1-t1.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r2-t1.1-t3.1",
"type": "adjacent_to",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r3-t3.1-t1.1",
"type": "adjacent_to",
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"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r4-t1.1-t3.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r5-t3.1-t4.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r6-t1.1-t4.1",
"type": "location_of",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s3-t4",
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},
{
"id": "DerHautarzt.90500198.eng.abstr-s3-r7-t3.1-t2.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r1-t2.1-t3.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r2-t3.1-t2.1",
"type": "associated_with",
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},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r3-t3.1-t1.1",
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"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r4-t2.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r5-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r6-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r7-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500198.eng.abstr-s4-r8-t3.1-t2.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.90500198.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500198.eng.abstr-s4-t2",
"normalized": []
}
] |
DerHautarzt.90500203.eng.abstr
|
DerHautarzt.90500203.eng.abstr
|
[
{
"id": "DerHautarzt.90500203.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cutaneous myiasis is a temporary infestation of the skin with fly larvae . Travelling to subtropical areas accounts for a higher risk and increasing incidence in Europeans . In Middle- and South America myiasis is mainly caused by the botfly ( Dermatobia hominis ) . Blood-suckling arthropods , usually mosquitoes , transmit the larvae of the botfly via phoresis , a unique mechanism of egg deposition . In Africa cutaneous myiasis is mostly due to the tumbu fly ( Cordylobia anthropophaga ) . Infection with the tumbu fly larvae occurs after direct contact with the eggs that are often deposited in clothes and towels . Clinically an abscess-like lesion develops . Creeping sensations of movement under the skin are occasionally described . Following hatching , spontaneous healing can normally be expected , although extraction of the larvae is recommended to prevent abscess formation and superinfection ."
],
"offsets": [
[
0,
908
]
]
}
] |
[
{
"id": "DerHautarzt.90500203.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"myiasis"
],
"offsets": [
[
10,
17
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027030"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
52,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"larvae"
],
"offsets": [
[
66,
72
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023047"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"fly larvae"
],
"offsets": [
[
62,
72
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016386"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"risk"
],
"offsets": [
[
129,
133
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035647"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"incidence"
],
"offsets": [
[
149,
158
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220856"
},
{
"db_name": "UMLS",
"db_id": "C0021149"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"increasing incidence"
],
"offsets": [
[
138,
158
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220888"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"America"
],
"offsets": [
[
195,
202
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002454"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"myiasis"
],
"offsets": [
[
203,
210
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027030"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"South America"
],
"offsets": [
[
189,
202
]
],
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{
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"db_id": "C0037713"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"arthropods"
],
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282,
292
]
],
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"db_id": "C0003903"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"mosquitoes"
],
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[
303,
313
]
],
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{
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"db_id": "C0026582"
},
{
"db_name": "UMLS",
"db_id": "C0026584"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"larvae"
],
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329,
335
]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"phoresis"
],
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354,
362
]
],
"normalized": [
{
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"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"egg"
],
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[
387,
390
]
],
"normalized": [
{
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"db_id": "C0029974"
},
{
"db_name": "UMLS",
"db_id": "C0013710"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Africa"
],
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407,
413
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],
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"db_id": "C0001737"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"myiasis"
],
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424,
431
]
],
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{
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"db_id": "C0027030"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"Infection"
],
"offsets": [
[
494,
503
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"larvae"
],
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[
523,
529
]
],
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{
"db_name": "UMLS",
"db_id": "C0023047"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"direct"
],
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[
543,
549
]
],
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{
"db_name": "UMLS",
"db_id": "C0700157"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"eggs"
],
"offsets": [
[
567,
571
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0029974"
},
{
"db_name": "UMLS",
"db_id": "C0013710"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"fly larvae"
],
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[
519,
529
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016386"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"abscess-like"
],
"offsets": [
[
635,
647
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000833"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"sensations"
],
"offsets": [
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675,
685
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036658"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"movement"
],
"offsets": [
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689,
697
]
],
"normalized": [
{
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"db_id": "C0026649"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
708,
712
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500203.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"larvae"
],
"offsets": [
[
837,
843
]
],
"normalized": [
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DerHautarzt.90500208.eng.abstr
|
DerHautarzt.90500208.eng.abstr
|
[
{
"id": "DerHautarzt.90500208.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 76-year-old female patient developed severe manifestations of a kaposi-like acroangiodermatitis ( so-called Mali's disease ) due to chronic venous insufficiency of the lower extremities . The patient presented with large areas of confluent , violaceous or brown-black papules on both lower legs . Histologically , proliferation of thick-walled capillaries was seen in the upper dermis consisting of fully differentiated endothelial cells , as shown by immunohistochemistry . In contrast to true Kaposi's sarcoma , human-herpes-virus-8 DNA could not be detected by polymerase-chain-reaction in this condition . We review the diagnostic criteria used to distinguish between acroangiodermatitis , also called pseudo-Kaposi's sarcoma , and the true Kaposi's sarcoma ."
],
"offsets": [
[
0,
765
]
]
}
] |
[
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20
]
],
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]
},
{
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],
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21,
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]
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"disease"
],
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]
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},
{
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"extremities"
],
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[
176,
187
]
],
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"db_id": "C0015385"
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},
{
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"venous insufficiency"
],
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142,
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]
],
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{
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"lower extremities"
],
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[
170,
187
]
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{
"id": "DerHautarzt.90500208.eng.abstr-s1-t7",
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"chronic venous insufficiency"
],
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[
134,
162
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],
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"patient"
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194,
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]
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}
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},
{
"id": "DerHautarzt.90500208.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"brown-black"
],
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[
258,
269
]
],
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{
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"db_id": "C0037162"
}
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},
{
"id": "DerHautarzt.90500208.eng.abstr-s2-t3",
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"text": [
"legs"
],
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[
292,
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]
],
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{
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],
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]
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"id": "DerHautarzt.90500208.eng.abstr-s3-t3",
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"cells"
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[] |
[] |
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DerHautarzt.90500214.eng.abstr
|
DerHautarzt.90500214.eng.abstr
|
[
{
"id": "DerHautarzt.90500214.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Embolia cutis medicamentosa ( Nicolau Syndrom ) is a very rare complication of intramuscular injections which presents with extensive necrosis of the injected skin area . Intra-arterial and/or para-arterial injections after prior perforation of certain vessels are discussed as possible pathogenetic mechanisms . We describe the occurrence of embolia cutis medicamentosa after intra-articular injections into the knee ."
],
"offsets": [
[
0,
419
]
]
}
] |
[
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{
"id": "DerHautarzt.90500214.eng.abstr-s1-t3",
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{
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{
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{
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{
"id": "DerHautarzt.90500214.eng.abstr-s3-t3",
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] |
[] |
[] |
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"arg2_id": "DerHautarzt.90500214.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.90500214.eng.abstr-s1-r14-t3.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.90500214.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.90500214.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.90500214.eng.abstr-s2-r1-t3.2-t3.1",
"type": "disrupts",
"arg1_id": "DerHautarzt.90500214.eng.abstr-s2-t3",
"arg2_id": "DerHautarzt.90500214.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.90500214.eng.abstr-s2-r2-t3.1-t3.2",
"type": "produces",
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"arg2_id": "DerHautarzt.90500214.eng.abstr-s2-t3",
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},
{
"id": "DerHautarzt.90500214.eng.abstr-s3-r1-t1.1-t3.1",
"type": "measurement_of",
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},
{
"id": "DerHautarzt.90500214.eng.abstr-s3-r2-t1.1-t4.1",
"type": "conceptual_part_of",
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"arg2_id": "DerHautarzt.90500214.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500214.eng.abstr-s3-r3-t4.1-t1.1",
"type": "isa",
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"arg2_id": "DerHautarzt.90500214.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.90500214.eng.abstr-s3-r4-t3.1-t4.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.90500214.eng.abstr-s3-t4",
"normalized": []
}
] |
DerHautarzt.90500243.eng.abstr
|
DerHautarzt.90500243.eng.abstr
|
[
{
"id": "DerHautarzt.90500243.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Classification of cosmetics , which are more and more similar to topical therapeutic agents , is getting increasingly difficult for dermatologists . Their definition within the EU and the respective European directives , replacing national laws step by step , will be briefly presented . The problems of distinguishing cosmetics from medicinal products will be discusssed in detail by examples from clinical practice . Finally , we will review the various active substances which tend to be added to cosmetics following the global trend in the cosmetic industry towards developing \" medicinally \" active cosmetics , and in the pharmaceutical industry towards \" cosmetically \" oriented medicinal products as part of a current \" life-style \" ideology . In some clinical dermatological fields these active substances may allow the dermatologists to use cosmetics as topical therapeutic agents ."
],
"offsets": [
[
0,
891
]
]
}
] |
[
{
"id": "DerHautarzt.90500243.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Classification"
],
"offsets": [
[
0,
14
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008902"
},
{
"db_name": "UMLS",
"db_id": "C0008903"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cosmetics"
],
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[
18,
27
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
73,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039796"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"national"
],
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[
231,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0015737"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"laws"
],
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[
240,
244
]
],
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{
"db_name": "UMLS",
"db_id": "C0220866"
},
{
"db_name": "UMLS",
"db_id": "C0023150"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"cosmetics"
],
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[
319,
328
]
],
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{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"cosmetics"
],
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[
500,
509
]
],
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{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"trend"
],
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[
531,
536
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040833"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"cosmetic"
],
"offsets": [
[
544,
552
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"industry"
],
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[
553,
561
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021267"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"cosmetics"
],
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[
604,
613
]
],
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{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"industry"
],
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[
642,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0021267"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t7",
"type": "umlsterm",
"text": [
"life-style"
],
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727,
737
]
],
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{
"db_name": "UMLS",
"db_id": "C0376558"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-t8",
"type": "umlsterm",
"text": [
"pharmaceutical industry"
],
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[
627,
650
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013185"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"cosmetics"
],
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850,
859
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.90500243.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
871,
882
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039796"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.90500243.eng.abstr-s1-r1-t3.1-t1.2",
"type": "uses",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s1-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-r1-t1.1-t2.2",
"type": "produces",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-r2-t2.2-t2.1",
"type": "isa",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-r3-t1.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s2-r4-t2.2-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-r1-t8.1-t6.1",
"type": "carries_out",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s4-t8",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s4-t6",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-r2-t8.1-t4.1",
"type": "carries_out",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s4-t8",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s4-t4",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s4-r3-t2.1-t7.1",
"type": "isa",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s4-t7",
"normalized": []
},
{
"id": "DerHautarzt.90500243.eng.abstr-s5-r1-t2.1-t1.1",
"type": "uses",
"arg1_id": "DerHautarzt.90500243.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.90500243.eng.abstr-s5-t1",
"normalized": []
}
] |
DerHautarzt.90500250.eng.abstr
|
DerHautarzt.90500250.eng.abstr
|
[
{
"id": "DerHautarzt.90500250.eng.abstr-passage-0",
"type": "abstract",
"text": [
"S100 is an acidic-calcium-binding protein , composed as a heterodimer of two isomeric subunits and and was first described in cells of neuroendocrine origin . It plays an important role in various cellular processes such as cell differentiation and proliferation and interacts with the tumour suppressor gene p53. S100 is also present in melanoma cells and its immunhistochemical detection is widely used in the histopathological diagnosis of malignant melanoma . S100 has been detected in the serum of patients with malignant melanoma and many clinical studies have been performed to establish this protein as a tumor marker in different stages of the disease . The data suggest that S-100-protein in serum of patients with malignant melanoma could be an independent prognostic marker and an additional clinical parameter for progression of metastatic disease and serological monitoring during systemic therapy . However there are patients in stage of lymph node- or systemic metastasis with negative S-100-serum levels and no correlation to the course of disease . Our results confirm the findings for patients in stage III/IV . However , the percentage of S-100-positive patients in stage III/IV is lower than reported in the literature , if repeatedly positive samples are excluded from statistical analysis . For monitoring in stage I and II it seems to be not helpful ."
],
"offsets": [
[
0,
1375
]
]
}
] |
[
{
"id": "DerHautarzt.90500250.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"acidic-calcium-binding"
],
"offsets": [
[
11,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006675"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"acidic-calcium-binding"
],
"offsets": [
[
11,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243122"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"protein"
],
"offsets": [
[
34,
41
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
126,
131
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"origin"
],
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[
150,
156
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079946"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"role"
],
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[
181,
185
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035820"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"cell"
],
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[
224,
228
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tumour"
],
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[
286,
292
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"gene"
],
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[
304,
308
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017337"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
338,
346
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"cells"
],
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[
347,
352
]
],
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{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"histopathological"
],
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412,
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]
],
"normalized": [
{
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"db_id": "C0243140"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"diagnosis"
],
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"db_id": "C0011900"
},
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"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"malignant"
],
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443,
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],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
453,
461
]
],
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{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"cell differentiation"
],
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[
224,
244
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007589"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"suppressor gene"
],
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[
293,
308
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017372"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s2-t13",
"type": "umlsterm",
"text": [
"malignant melanoma"
],
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[
443,
461
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patients"
],
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[
503,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"malignant"
],
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[
517,
526
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
527,
535
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"protein"
],
"offsets": [
[
600,
607
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"tumor"
],
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[
613,
618
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"marker"
],
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[
619,
625
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005516"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"stages"
],
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[
639,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027646"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
653,
660
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"malignant melanoma"
],
"offsets": [
[
517,
535
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500250.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"clinical studies"
],
"offsets": [
[
545,
561
]
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] |
DerHautarzt.90500257.eng.abstr
|
DerHautarzt.90500257.eng.abstr
|
[
{
"id": "DerHautarzt.90500257.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Ehlers-Danlos syndrome ( EDS ) comprises a heterogenous group of nine hereditary connective tissue disorders , characterized by hyperelasticity of skin and hypermobility of joints to differing extents . The skin is easily injured and wound healing is delayed . The majority of EDS patients belong to EDS-types I-III . The pathogenesis in these cases is not known , although recent data suggest a role for collagen V. In contrast , the etiology of EDS-types IV , VI and VII has been found . While EDS IV is caused by a mutation in the collagen III gene , in EDS VI a mutation in the lysyl hydroxylase gene is present . In EDS VII , the underlying defect is a mutation in the collagen I gene . The EDS-types V , VII and X are very rare ; their symptoms resemble those of EDS-type II ."
],
"offsets": [
[
0,
786
]
]
}
] |
[
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{
"id": "DerHautarzt.90500257.eng.abstr-s1-t2",
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"EDS"
],
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32
]
],
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}
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},
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"id": "DerHautarzt.90500257.eng.abstr-s1-t3",
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"text": [
"tissue"
],
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]
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{
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}
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},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"hyperelasticity"
],
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147
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],
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"db_id": "C0013764"
}
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},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t6",
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"text": [
"skin"
],
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151,
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]
],
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]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t7",
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"joints"
],
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]
],
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}
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},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"Ehlers-Danlos syndrome"
],
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26
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],
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}
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},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"connective tissue"
],
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85,
102
]
],
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"db_id": "C0009780"
}
]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"connective tissue disorders"
],
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85,
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]
],
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"db_id": "C0009782"
}
]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
"hypermobility of joints"
],
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160,
183
]
],
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}
]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"skin"
],
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[
211,
215
]
],
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"wound"
],
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]
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"db_id": "C0021501"
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]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"wound healing"
],
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238,
251
]
],
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"db_id": "C0043240"
}
]
},
{
"id": "DerHautarzt.90500257.eng.abstr-s3-t1",
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"text": [
"EDS"
],
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"id": "DerHautarzt.90500257.eng.abstr-s4-t1",
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"pathogenesis"
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"id": "DerHautarzt.90500257.eng.abstr-s4-t3",
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"collagen"
],
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"id": "DerHautarzt.90500257.eng.abstr-s5-t1",
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] |
[] |
[] |
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DerHautarzt.90500266.eng.abstr
|
DerHautarzt.90500266.eng.abstr
|
[
{
"id": "DerHautarzt.90500266.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Adjuvant therapy with interferon for malignant melanoma causes neurotoxic side effects such as depression . The biochemical mechanisms are unknown . We report two cases with both depression and amnesia . In one case , attempted suicide was a companied by 7 h of amnesia . The diagnostic classification and possible explanations for the amnesia secondary to interferon therapy are reviewed ."
],
"offsets": [
[
0,
390
]
]
}
] |
[
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t1",
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"text": [
"Adjuvant"
],
"offsets": [
[
0,
8
]
],
"normalized": [
{
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"db_id": "C0001551"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"therapy"
],
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[
9,
16
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t3",
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"text": [
"interferon"
],
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[
22,
32
]
],
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"db_id": "C0021747"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t4",
"type": "umlsterm",
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"malignant"
],
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[
37,
46
]
],
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{
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"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
47,
55
]
],
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{
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"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t6",
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"text": [
"neurotoxic"
],
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[
63,
73
]
],
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"db_id": "C0600688"
}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t7",
"type": "umlsterm",
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"depression"
],
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]
],
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},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t8",
"type": "umlsterm",
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],
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55
]
],
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}
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},
{
"id": "DerHautarzt.90500266.eng.abstr-s1-t9",
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"side effects"
],
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[
74,
86
]
],
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}
]
},
{
"id": "DerHautarzt.90500266.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"depression"
],
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[
179,
189
]
],
"normalized": [
{
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}
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},
{
"id": "DerHautarzt.90500266.eng.abstr-s3-t2",
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"amnesia"
],
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[
194,
201
]
],
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}
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},
{
"id": "DerHautarzt.90500266.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
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] |
DerHautarzt.90500270.eng.abstr
|
DerHautarzt.90500270.eng.abstr
|
[
{
"id": "DerHautarzt.90500270.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Palpable arciform migratory erythema of Clark ( PAME ) has been described as a rare member in the group of T-cell pseudolymphoma . The clinical picture of infiltrated annular erythema developing into large migrating lesions with the trunk as predilection site is distinctive from other pseudolymphomas . Because of the very similar histology and immunohistochemistry in comparison to the more frequent lymphocytic infiltration of the skin of Jessner and Kanof ( LIS ) doubts have been raised about the existence of PAME as an unique entity . A 46-year old patient presented with the typical picture of PAME on his trunk while showing typical lesions of LIS on his neck and face . Both diseases showed synchronous intermittent remissions in response to different therapeutic modalities . Multiple biopsies were subsequently performed and histological , immunohistochemical and molecular biological examinations did not reveal relevant differences between PAME and LIS in this patient . We conclude that the findings in this key case suggest that the T-cell pseudolymphoma PAME is not an unique entity , but a special clinical presentation of LIS ."
],
"offsets": [
[
0,
1146
]
]
}
] |
[
{
"id": "DerHautarzt.90500270.eng.abstr-s1-t1",
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"erythema"
],
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28,
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]
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]
},
{
"id": "DerHautarzt.90500270.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"PAME"
],
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[
48,
52
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],
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}
]
},
{
"id": "DerHautarzt.90500270.eng.abstr-s1-t3",
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"text": [
"T-cell"
],
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[
107,
113
]
],
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}
]
},
{
"id": "DerHautarzt.90500270.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"pseudolymphoma"
],
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114,
128
]
],
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{
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"erythema"
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},
{
"id": "DerHautarzt.90500270.eng.abstr-s2-t2",
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"pseudolymphomas"
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[
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],
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"id": "DerHautarzt.90500270.eng.abstr-s3-t1",
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332,
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{
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{
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"skin"
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{
"id": "DerHautarzt.90500270.eng.abstr-s3-t4",
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"PAME"
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"old"
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"patient"
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"PAME"
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{
"id": "DerHautarzt.90500270.eng.abstr-s4-t4",
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"neck"
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"face"
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}
] |
[] |
[] |
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] |
DerHautarzt.90500280.eng.abstr
|
DerHautarzt.90500280.eng.abstr
|
[
{
"id": "DerHautarzt.90500280.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The papular-purpuric \" gloves and socks \" syndrome ( PPGSS ) was first described in 1990 by Harms et al. The syndrome is characterised by fever , an itchy erythema with edema , confluent papules and purpura of the hands and feet in a \" gloves and socks \" distribution . The skin lesions may be associated with purpura and superficial erosions of the oral mucosa . Viral infections , in particular parvovirus B19, are the most likely trigger . In the present case PPGSS developed after taking trimethoprim/sulfamethoxazole . Since the patient developed identical symptoms after accidental re-challenge with the same drug , this case strongly suggests medications as another factor in the pathogenesis of PPGSS ."
],
"offsets": [
[
0,
710
]
]
}
] |
[
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t1",
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"gloves"
],
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]
],
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{
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"type": "umlsterm",
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"syndrome"
],
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]
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"id": "DerHautarzt.90500280.eng.abstr-s1-t3",
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"syndrome"
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}
]
},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"fever"
],
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t5",
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"text": [
"itchy"
],
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149,
154
]
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t6",
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"erythema"
],
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155,
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{
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}
]
},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t7",
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"edema"
],
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},
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"id": "DerHautarzt.90500280.eng.abstr-s1-t8",
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"purpura"
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t9",
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"hands"
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{
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}
]
},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t10",
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"text": [
"feet"
],
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]
],
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"db_id": "C0016504"
}
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t11",
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"gloves"
],
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}
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s1-t12",
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"distribution"
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],
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{
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}
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s2-t1",
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"text": [
"skin"
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}
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s2-t2",
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"purpura"
],
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}
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mucosa"
],
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355,
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"oral mucosa"
],
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],
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},
{
"id": "DerHautarzt.90500280.eng.abstr-s3-t1",
"type": "umlsterm",
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"Viral"
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{
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{
"id": "DerHautarzt.90500280.eng.abstr-s3-t3",
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"text": [
"parvovirus"
],
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{
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"id": "DerHautarzt.90500280.eng.abstr-s5-t2",
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"symptoms"
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{
"id": "DerHautarzt.90500280.eng.abstr-s5-t3",
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"drug"
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] |
[] |
[] |
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DerHautarzt.90500284.eng.abstr
|
DerHautarzt.90500284.eng.abstr
|
[
{
"id": "DerHautarzt.90500284.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Two years after the diagnosis of Sézary syndrome , a 50-year old female patient experienced attacks of painful ischemia of both hands and feet , leading to acral necrosis . Another 59-year old patient presented with severe pain in his feet , secondary to ischemia . This was the first symptom of a T-cell-chronic lymphocytic leukemia . Similar cases have only occasionally been described . The relationship between acral ischemia and T-cell-lymphoma is not clear but is discussed in this article ."
],
"offsets": [
[
0,
497
]
]
}
] |
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{
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{
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DerHautarzt.90500288.eng.abstr
|
DerHautarzt.90500288.eng.abstr
|
[
{
"id": "DerHautarzt.90500288.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Immunohistologically linear IgA disease presents with unambiguous features , whereas clinical manifestations are variable . It sometimes shows similarity to other bullous dermatoses such as bullous pemphigoid and dermatitis herpetiformis . A 73 year old female patient was referred with the diagnosis of bullous pemphigoid . One day after admission clinical examination revealed the classical features of Stevens-Johnson syndrome ( SJS ) : widespread confluent atypical target lesions , partly raised , partly flat with central blisters , and erythematous spots , but few typical targets , as well as blisters and large areas of skin detachment on her back and buttocks , accompanied by erosions of the oral and genital mucosa . Direct immunofluorescence performed on peri-lesional skin showed linear deposition of IgA along the basement membrane zone , leading to the diagnosis of linear IgA disease of adults . Our case report shows that linear IgA disease may present with the clinical pattern of SJS ."
],
"offsets": [
[
0,
1005
]
]
}
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[] |
[] |
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] |
DerHautarzt.90500295.eng.abstr
|
DerHautarzt.90500295.eng.abstr
|
[
{
"id": "DerHautarzt.90500295.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Keratosis follicularis spinulosa decalvans ( KFSD ) appeared sporadically in an Asian boy , who also presented with naevus teleangiectaticus lateralis , patent ductus arteriosus ( Botalli ) and hypospadia . The association of these findings raises the question of a new syndrome . In addition , this is the first report of KFSD in a patient of Asian origin ."
],
"offsets": [
[
0,
358
]
]
}
] |
[
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t1",
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"text": [
"Keratosis"
],
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[
0,
9
]
],
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{
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"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Asian"
],
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[
80,
85
]
],
"normalized": [
{
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"db_id": "C0078988"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"naevus"
],
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[
116,
122
]
],
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{
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"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"patent"
],
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[
153,
159
]
],
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{
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"db_id": "C0030650"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Botalli"
],
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[
180,
187
]
],
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{
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"db_id": "C0002367"
},
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"db_id": "C0002563"
},
{
"db_name": "UMLS",
"db_id": "C0001898"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"hypospadia"
],
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[
194,
204
]
],
"normalized": [
{
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"db_id": "C0020646"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"Keratosis follicularis"
],
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[
0,
22
]
],
"normalized": [
{
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"db_id": "C0022595"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"ductus arteriosus"
],
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[
160,
177
]
],
"normalized": [
{
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"db_id": "C0013273"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"patent ductus arteriosus"
],
"offsets": [
[
153,
177
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013274"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"association"
],
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[
211,
222
]
],
"normalized": [
{
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"db_id": "C0004083"
}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"findings"
],
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[
232,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"syndrome"
],
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]
],
"normalized": [
{
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},
{
"id": "DerHautarzt.90500295.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patient"
],
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]
],
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},
{
"id": "DerHautarzt.90500295.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"Asian"
],
"offsets": [
[
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]
],
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}
]
},
{
"id": "DerHautarzt.90500295.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"origin"
],
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[
350,
356
]
],
"normalized": [
{
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"db_id": "C0079946"
}
]
}
] |
[] |
[] |
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DerHautarzt.90500299.eng.abstr
|
DerHautarzt.90500299.eng.abstr
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DerHautarzt.90500323.eng.abstr
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DerHautarzt.90500323.eng.abstr
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"Our therapeutic approach to atopic eczema consists of a continous topical dermatological basic therapy in combination with an antiinflammatory therapy in phases of exacerbations . In the treatment of exacerbated atopic eczema , systemic agents are added to achieve effective control more rapidly or to induce remissions in cases refractory to standard therapy . Antihistamines to control the pruritus , as well as antibiotics and acyclovir for antimicrobial superinfections are often used . In many patients exacerbations can be successfully controlled with phototherapy , especially with UVA1 light . The use of systemic immunosuppressants , like glucocorticosteroids , cyclosporine or azathioprine generally can be avoided and is a therapeutic alternative only in few selected cases . In the last years promising new experimental treatments have evolved , which could become therapeutic alternatives for the future ."
],
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}
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DerHautarzt.90500330.eng.abstr
|
DerHautarzt.90500330.eng.abstr
|
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368
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}
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[] |
[] |
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DerHautarzt.90500338.eng.abstr
|
DerHautarzt.90500338.eng.abstr
|
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"id": "DerHautarzt.90500338.eng.abstr-passage-0",
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"text": [
"There is a lot of information in the literature about psychological disturbances in somatic diseases . For dermatological patients such data are not available . In early spring 1998 we studied the psychological changes in 247 hospitalized patients in the dermatological department of the Ruhr University Bochum . We used the German version of the internationally accepted Hospital Anxiety and Depression Scale . We found the prevalance of psychological alterations ranged between 25,9% and 31% . The prevalence of psychological disturbances was a little higher than that seen in oncological , cardiological or neurological patient populations . Surprisingly skin cancer patients were less affected than patients with chronic inflammatory or angiological diseases . These results underline the necessity of improved psychological therapeutical strategies which must be standardized and evaluated ."
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[] |
[] |
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] |
DerHautarzt.90500344.eng.abstr
|
DerHautarzt.90500344.eng.abstr
|
[
{
"id": "DerHautarzt.90500344.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Seventeen patients with extensive subacute prurigo , often resistant to different regimens of prior external and internal therapy , were treated with PUVA bath photochemotherapy ( psoralen bath followed by UVA irradiation ) using bath water containing 0,5 mg/l of 8-methoxypsoralen ( 8-MOP ) . In 15 of 17 patients treated , the skin lesions showed a significant improvement or even complete clearance within 8 weeks of therapy . In two patients , only limited clinical improvement was achieved . Follow-up after 6 weeks revealed sustained improvement in the successfully treated patients . The mean cumulative UVA dose given until clearance was 30,3 ( SD +/- 12,6 ) J/cm2. Therefore , a mean of 24,1 ( SD +/- 5,3 ) PUVA bath treatments was necessary . No side effects were seen except phototoxic reactions in two patients manifested as slight erythema . The results of this trial show that PUVA bath photochemotherapy with 8-MOP is an effective therapeutic alternative to other known therapies in subacute prurigo . Compared to oral PUVA therapy or other topical and systemic treatments , PUVA bath photochemotherapy with 8-MOP shows an excellent efficiency-side effect ratio . The clearance of chronic skin lesions refractive to other topical or systemic treatments by PUVA bath photochemotherapy with 8-MOP demonstrates that this therapy can be even superior to other common therapeutic modalities used for subacute prurigo ."
],
"offsets": [
[
0,
1428
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.90500355.eng.abstr
|
DerHautarzt.90500355.eng.abstr
|
[
{
"id": "DerHautarzt.90500355.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 58-year-old man developed an extensive pilomatrical carcinoma in the left axilla . Clinically , a squamous cell carcinoma was suspected . Histological examination revealed the presence of proliferating basaloid cells with many atypical mitoses and mass necrosis infiltrating into the subcutaneous tissue . The tumor was removed by micrographic surgery with a 2 cm safety margin . Histological examination of 2 regional lymph nodes as well as further diagnostic procedures ruled out metastases . We review the clinical and histopathological differences between pilomatricoma and pilomatrical carcinoma , as well as the published cases of the malignant variant ."
],
"offsets": [
[
0,
662
]
]
}
] |
[
{
"id": "DerHautarzt.90500355.eng.abstr-s1-t1",
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"man"
],
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[
14,
17
]
],
"normalized": [
{
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"db_id": "C0025266"
},
{
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"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.90500355.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"carcinoma"
],
"offsets": [
[
54,
63
]
],
"normalized": [
{
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"db_id": "C0007097"
}
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},
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]
}
] |
[] |
[] |
[
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}
] |
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